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https://www.readbyqxmd.com/read/28811953/from-inflammation-to-current-and-alternative-therapies-involved-in-wound-healing
#1
REVIEW
Mariana Barreto Serra, Wermerson Assunção Barroso, Neemias Neves da Silva, Selma do Nascimento Silva, Antonio Carlos Romão Borges, Iracelle Carvalho Abreu, Marilene Oliveira da Rocha Borges
Wound healing is a complex event that develops in three overlapping phases: inflammatory, proliferative, and remodeling. These phases are distinct in function and histological characteristics. However, they depend on the interaction of cytokines, growth factors, chemokines, and chemical mediators from cells to perform regulatory events. In this article, we will review the pathway in the skin healing cascade, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28807666/microrna-132-with-therapeutic-potential-in-chronic-wounds
#2
Xi Li, Dongqing Li, Aoxue Wang, Tongbin Chu, Warangkana Lohcharoenkal, Xiaowei Zheng, Jacob Grünler, Sampath Narayanan, Sofie Eliasson, Eva K Herter, Yang Wang, Yannan Ma, Marcus Ehrström, Liv Eidsmo, Maria Kasper, Andor Pivarcsi, Enikö Sonkoly, Sergiu-Bogdan Catrina, Mona Ståhle, Ning Xu Landén
Chronic wounds represent a major and rising health and economic burden worldwide. There is a continued search towards more effective wound therapy. We found significantly reduced microRNA-132 (miR-132) expression in human diabetic ulcers compared to normal skin wounds, and also in skin wounds of leptin receptor-deficient (db/db) diabetic mice compared to wild-type mice. Local replenishment of miR-132 in the wounds of db/db mice accelerated wound closure effectively, which was accompanied by increased proliferation of wound-edge keratinocytes and reduced inflammation...
August 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28800645/analysis-of-endogenous-lipids-during-intestinal-wound-healing
#3
Yunna Lee, Jieun Choo, Su Jin Kim, Gwangbeom Heo, Charalabos Pothoulakis, Yong-Hak Kim, Eunok Im
Intestinal wound healing is a new therapeutic goal for inflammatory bowel disease (IBD) as complete healing of the mucosa is the key element of clinical remission in IBD. Previous studies showed that termination of inflammation can be achieved by adding pro-resolving lipids like DHA and EPA exogenously. However, the roles of these lipids in mucosal healing have not been investigated. To recapitulate intestinal healing process, mice were received dextran sodium sulfate (DSS) for 7 days in the drinking water followed by regular tap water for 5 additional days...
2017: PloS One
https://www.readbyqxmd.com/read/28800463/combination-of-dexamethasone-and-avastin-%C3%A2-by-supramolecular-hydrogel-attenuates-the-inflammatory-corneal-neovascularization-in-rat-alkali-burn-model
#4
Jinhai Huang, Wenwen Wang, Jing Yu, Xinxin Yu, Qianqian Zheng, Fangli Peng, Zhifen He, Wenguang Zhao, Zhaoliang Zhang, Xingyi Li, Qinmei Wang
Corneal neovascularization (CNV) is one of the leading causes of vision loss and a high-risk factor for transplant rejection. The present study proposed a supramolecular hydrogel comprised of MPEG-PCL micelles and α-cyclodextrin (α-CD) for co-delivery of dexamethasone sodium phosphate (Dexp) and Avastin(®) (Ava), and further evaluated its therapeutic efficacy in rat alkali burn model. A physical mixing of Dexp/Ava, MPEG-PCL micelles, and α-CD aqueous solution leads to a spontaneous formation of the supramolecular hydrogel via a "host-guest" recognition between MPEG and α-CD...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28798904/tick-borne-viruses-and-biological-processes-at-the-tick-host-virus-interface
#5
REVIEW
Mária Kazimírová, Saravanan Thangamani, Pavlína Bartíková, Meghan Hermance, Viera Holíková, Iveta Štibrániová, Patricia A Nuttall
Ticks are efficient vectors of arboviruses, although less than 10% of tick species are known to be virus vectors. Most tick-borne viruses (TBV) are RNA viruses some of which cause serious diseases in humans and animals world-wide. Several TBV impacting human or domesticated animal health have been found to emerge or re-emerge recently. In order to survive in nature, TBV must infect and replicate in both vertebrate and tick cells, representing very different physiological environments. Information on molecular mechanisms that allow TBV to switch between infecting and replicating in tick and vertebrate cells is scarce...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28797647/matrix-metalloproteinases-the-sculptors-of-chronic-cutaneous-wounds
#6
REVIEW
Venkat Raghavan Krishnaswamy, Dvir Mintz, Irit Sagi
Cutaneous wound healing is a complex mechanism with multiple processes orchestrating harmoniously for structural and functional restoration of the damaged tissue. Chronic non-healing wounds plagued with infection create a major healthcare burden and is one of the most frustrating clinical problems. Chronic wounds are manifested by prolonged inflammation, defective re-epithelialization and haphazard remodeling. Matrix metalloproteinases (MMPs) are zinc dependent enzymes that play cardinal functions in wound healing...
August 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28783760/total-glucosides-of-paeony-inhibits-lipopolysaccharide-induced-proliferation-migration-and-invasion-in-androgen-insensitive-prostate-cancer-cells
#7
Zhi-Hui Zhang, Dong-Dong Xie, Shen Xu, Mi-Zhen Xia, Zhi-Qiang Zhang, Hao Geng, Lei Chen, Da-Ming Wang, Wei Wei, De-Xin Yu, De-Xiang Xu
Previous studies demonstrated that inflammatory microenvironment promoted prostate cancer progression. This study investigated whether total glucosides of paeony (TGP), the active constituents extracted from the root of Paeonia Lactiflora Pall, suppressed lipopolysaccharide (LPS)-stimulated proliferation, migration and invasion in androgen insensitive prostate cancer cells. PC-3 cells were incubated with LPS (2.0 μg/mL) in the absence or presence of TGP (312.5 μg /mL). As expected, cells at S phase and nuclear CyclinD1, the markers of cell proliferation, were increased in LPS-stimulated PC-3 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28782184/integrin-mediated-interactions-control-macrophage-polarization-in-3d-hydrogels
#8
Byung-Hyun Cha, Su Ryon Shin, Jeroen Leijten, Yi-Chen Li, Sonali Singh, Julie C Liu, Nasim Annabi, Reza Abdi, Mehmet R Dokmeci, Nihal Engin Vrana, Amir M Ghaemmaghami, Ali Khademhosseini
Adverse immune reactions prevent clinical translation of numerous implantable devices and materials. Although inflammation is an essential part of tissue regeneration, chronic inflammation ultimately leads to implant failure. In particular, macrophage polarity steers the microenvironment toward inflammation or wound healing via the induction of M1 and M2 macrophages, respectively. Here, this paper demonstrates that macrophage polarity within biomaterials can be controlled through integrin-mediated interactions between human monocytic THP-1 cells and collagen-derived matrix...
August 7, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28782060/impacts-of-interleukin-17-neutralization-on-the-inflammatory-response-in-a-healing-ligament
#9
Anna Eb Clements, Connie S Chamberlain, Ellen M Leiferman, William L Murphy, Ray Vanderby
In this study, we sought to improve ligament healing by modulating the inflammatory response after acute injury through the neutralization of Interleukin-17 (IL-17), which we hypothesized would decrease inflammatory cell infiltration and cytokine production. Administration of an Interleukin-17 neutralizing antibody (IL-17 NA) immediately following a rat medial collateral ligament (MCL) transection resulted in alterations in inflammatory cell populations and cytokine expression within the healing ligament, but did not reduce inflammation...
May 2017: J Cytokine Biol
https://www.readbyqxmd.com/read/28771195/scar-prevention-and-enhanced-wound-healing-induced-by-polydeoxyribonucleotide-in-a-rat-incisional-wound-healing-model
#10
Woonhyeok Jeong, Chae Eun Yang, Tai Suk Roh, Jun Hyung Kim, Ju Hee Lee, Won Jai Lee
High-mobility group box protein-1 (HMGB-1) plays a central role in the inflammatory network, and uncontrolled chronic inflammation can lead to excessive scarring. The aim of this study was to evaluate the anti-inflammatory effects of polydeoxyribonucleotide (PDRN) on scar formation. Sprague-Dawley rats (n = 30) underwent dorsal excision of the skin, followed by skin repair. PDRN (8 mg/kg) was administered via intraperitoneal injection for three (PDRN-3 group, n = 8) or seven (PDRN-7 group, n = 8) days, and HMGB-1 was administered via intradermal injection in addition to PDRN treatment for three days (PDRN-3+HMGB-1 group; n = 6)...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28768721/the-glucocorticoid-receptor-in-monocyte-derived-macrophages-is-critical-for-cardiac-infarct-repair-and-remodeling
#11
Paolo Galuppo, Sabine Vettorazzi, Julian Hövelmann, Claus-Jürgen Scholz, Jan Peter Tuckermann, Johann Bauersachs, Daniela Fraccarollo
Cell- and tissue-specific actions of glucocorticoids are mediated by the glucocorticoid receptor. Here, we demonstrate that the glucocorticoid receptor (GR) in macrophages is essential for cardiac healing after myocardial infarction. Compared with GR(flox) (wild-type controls), GR(LysMCre) mice that lacked GR in myeloid cells showed increased acute mortality as a result of cardiac rupture. Seven days after left coronary artery ligation, GR(LysMCre) mice exhibited worse cardiac function and adverse remodeling associated with impaired scar formation and angiogenic response to ischemic injury...
August 2, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28760545/reactive-carbonyl-compounds-impair-wound-healing-by-vimentin-collapse-and-loss-of-the-primary-cilium
#12
Lara Rodríguez-Ribera, Craig Slattery, Tara Mc Morrow, Ricard Marcos, Susana Pastor
In renal pathologies tubulo-interstitial fibrosis results from an aberrant wound-healing ability where the normal epithelial tissue is substituted for scar tissue caused by accumulation of extracellular matrix proteins (ECM). During the wound-healing process, epithelial cells may undergo epithelial-mesenchymal transition (EMT) acquiring a mesenchymal-like phenotype that allows cells to migrate and re-epithelialize the wound site. It has been reported that chronic inflammation and uremic milieu are involved in wound-healing and enhanced kidney damage in chronic kidney disease (CKD) patients...
July 29, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28759428/negative-pressure-wound-therapy-for-patients-with-complex-abdominal-wounds
#13
Ahmet Bilgi, Fazilet Zumrut Biber Muftuler, Levent Akman, Emin Ilker Medine, Pinar Tonbaklar Bilgi, Ozge Kozgus Guldu, Sevki Goksun Gokulu, Volkan Tekin, Mustafa Cosan Terek
BACKGROUND: Research on treatment alternatives that improve wound healing is an ever-evolving area in medicine, and a wound healing agent that carries minimal pain, discomfort, and scarring for patients with burn wounds, venous and decubitis ulcers, traumatic wounds, and many others is needed. The phases of wound healing include homeostasis, inflammation, migration, proliferation, and maturation. Adeps suillus (axonge) is known as a therapeutic agent for skin diseases and mainly consists of triglycerides...
July 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28758717/epa%C3%A2-%C3%A2-dha-supplementation-reduces-pmn-activation-in-microenvironment-of-chronic-venous-leg-ulcers-a-randomized-double-blind-controlled-study
#14
Jodi C McDaniel, Laura Szalacha, Michelle Sales, Sashwati Roy, Scott Chafee, Narasimham Parinandi
Sustained high levels of activated polymorphonuclear leukocytes (PMNs) and PMN-derived proteases in the microenvironment of chronic venous leg ulcers (CVLUs) are linked to chronic inflammation and delayed healing. Uncontrolled PMN activity eventually destroys newly developed tissue and degrades critical growth factors. The bioactive components of fish oil (n-3 eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) have strong inflammation-resolving actions and have been shown to assuage PMN activity, but have not been tested in CVLU patients...
July 31, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28757565/the-pharmaceutical-device-prisma-%C3%A2-skin-promotes-in-vitro-angiogenesis-through-endothelial-to-mesenchymal-transition-during-skin-wound-healing
#15
Raffaella Belvedere, Valentina Bizzarro, Luca Parente, Francesco Petrella, Antonello Petrella
Glycosaminoglycans are polysaccharides of the extracellular matrix supporting skin wound closure. Mesoglycan is a mixture of glycosaminoglycans such as chondroitin-, dermatan-, heparan-sulfate and heparin and is the main component of Prisma(®) Skin, a pharmaceutical device developed by Mediolanum Farmaceutici S.p.a. Here, we show the in vitro effects of this device in the new vessels formation by endothelial cells, since angiogenesis represents a key moment in wound healing. We found a strong increase of migration and invasion rates of these cells treated with mesoglycan and Prisma(®) Skin which mediate the activation of the pathway triggered by CD44 receptor...
July 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28753648/lipoxin-a4-encapsulated-in-plga-microparticles-accelerates-wound-healing-of-skin-ulcers
#16
Mouzarllem Barros Reis, Priscilla Aparecida Tartari Pereira, Guilherme Ferreira Caetano, Marcel Nani Leite, Alyne Fávero Galvão, Francisco Wanderley Garcia Paula-Silva, Marco Andrey Cipriani Frade, Lúcia Helena Faccioli
Lipoxin A4 (LXA4) is involved in the resolution of inflammation and wound healing; however, it is extremely unstable. Thus, to preserve its biological activities and confer stability, we encapsulated LXA4 in poly-lactic-co-glycolic acid (PLGA) microparticles (LXA4-MS) and assessed its application in treating dorsal rat skin lesions. Ulcers were sealed with fibrin adhesive and treated with either LXA4-MS, unloaded microparticles (Un-MS), soluble LXA4, or PBS/glue (vehicle). All groups were compared at 0, 2, 7, and 14 days post-lesions...
2017: PloS One
https://www.readbyqxmd.com/read/28752029/advances-in-ultrasound-targeted-microbubble-mediated-gene-therapy-for-liver-fibrosis
#17
REVIEW
Cuiyuan Huang, Hong Zhang, Ruidan Bai
Hepatic fibrosis develops as a wound-healing scar in response to acute and chronic liver inflammation and can lead to cirrhosis in patients with chronic hepatitis B and C. The condition arises due to increased synthesis and reduced degradation of extracellular matrix (ECM) and is a common pathological sequela of chronic liver disease. Excessive deposition of ECM in the liver causes liver dysfunction, ascites, and eventually upper gastrointestinal bleeding as well as a series of complications. However, fibrosis can be reversed before developing into cirrhosis and has thus been the subject of extensive researches particularly at the gene level...
July 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28751250/wound-redox-gradients-revisited
#18
REVIEW
Philipp Niethammer
Evidence emerges that redox gradients regulate morphogenesis, inflammation, regeneration, and healing of tissues. At the example of redox signaling during the zebrafish wound response, I briefly discuss current ideas on how such patterns might be sensed and spatially regulated to guide physiological processes over distances in animals.
July 24, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28748217/mechanisms-and-applications-of-the-anti-inflammatory-effects-of-photobiomodulation
#19
Michael R Hamblin
Photobiomodulation (PBM) also known as low-level level laser therapy is the use of red and near-infrared light to stimulate healing, relieve pain, and reduce inflammation. The primary chromophores have been identified as cytochrome c oxidase in mitochondria, and calcium ion channels (possibly mediated by light absorption by opsins). Secondary effects of photon absorption include increases in ATP, a brief burst of reactive oxygen species, an increase in nitric oxide, and modulation of calcium levels. Tertiary effects include activation of a wide range of transcription factors leading to improved cell survival, increased proliferation and migration, and new protein synthesis...
2017: AIMS Biophysics
https://www.readbyqxmd.com/read/28747838/evaluation-of-nasal-fluid-%C3%AE-defensin-2-levels-in-children-with-allergic-rhinitis
#20
Fatih Dilek, Özkaya Emin, Bilge Gültepe, Mebrure Yazıcı, Erkan Çakır, Ahmet Hakan Gedik
AIM: Knowledge about the role of the innate immune system in the pathogenesis of allergic diseases has been expanding in recent years. Defensins are antimicrobial peptides that are components of the innate immune system. Defensins have strong efficacy against bacterial, viral, and fungal infections. Moreover, they have regulatory functions in many physiologic processes such as antitumoral immunity, chemotaxis, inflammation, and wound healing. In this study, we aimed to investigate β-defensin 2 levels in the nasal fluids of children with allergic rhinitis...
June 2017: Türk Pediatri Arşivi
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