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https://www.readbyqxmd.com/read/29432654/eccrine-sweat-glands-associate-with-the-human-hair-follicle-within-a-defined-compartment-of-dermal-white-adipose-tissue
#1
E Poblet, F Jimenez-Acosta, E Escario-Travesedo, J A Hardman, I Hernández-Hernández, J L Agudo-Mena, J J Cabrera-Galvan, C Nicu, R Paus
BACKGROUND: Eccrine sweat glands (ESGs) are critical for thermoregulation and involved in wound healing. ESGs have traditionally been considered as separate skin appendages without connection to the pilosebaceous unit (PSU). However, recent preliminary evidence has encouraged the hypothesis that PSU and ESG are more interconnected than previously thought. OBJECTIVE: To reevaluate the morphology of human skin adnexa with an integrated 3D perspective in order to explore the possible interconnections that the PSU and the ESG may form...
February 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29428355/dissecting-wnt-signaling-for-melanocyte-regulation-during-wound-healing
#2
Qi Sun, Piul Rabbani, Makoto Takeo, Soung-Hoon Lee, Chae Ho Lim, En-Nekema Shandi Noel, M Mark Taketo, Peggy Myung, Sarah Millar, Mayumi Ito
Abnormal pigmentation is commonly seen in the wound scar. Despite advancements in the research of wound healing, little is known about the repopulation of melanocytes in the healed skin. Previous studies have demonstrated the capacity of melanocyte stem cells (McSCs) in the hair follicle to contribute skin epidermal melanocytes following injury in mice and humans. Here, we focused on the Wnt pathway, known to be a vital regulator of McSCs in efforts to better understand the regulation of follicle-derived epidermal melanocytes during wound healing...
February 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29393477/long-non%C3%A2-coding-rna-regulates-hair-follicle-stem-cell-proliferation-and-differentiation-through-pi3k-akt-signal-pathway
#3
Bingjie Cai, Yunpeng Zheng, Shanshan Ma, Qu Xing, Xinxin Wang, Bo Yang, Guangwen Yin, Fangxia Guan
Long non-coding RNAs (lncRNAs) are defined as non-coding transcripts (>200 nucleotides) that serve important roles in the proliferation and differentiation of stem cells. Hair follicle stem cells (HFTs) have multidirectional differentiation potential and are able to differentiate into skin, hair follicles and sebaceous glands, serving a role in skin wound healing. The aim of the present study was to analyze the regulatory role of lncRNA AK015322 (IncRNA5322) in HFTs and the potential mechanism of IncRNA5322‑mediated differentiation of HFTs...
February 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29363542/ruxolitinib-protects-skin-stem-cells-and-maintains-skin-homeostasis-in-murine-graft-versus-host-disease
#4
Shuichiro Takahashi, Daigo Hashimoto, Eiko Hayase, Reiki Ogasawara, Hiroyuki Ohigashi, Takahide Ara, Emi Yokoyama, Ko Ebata, Satomi Matsuoka, Geoffrey Hill, Junichi Sugita, Masahiro Onozawa, Takanori Teshima
Graft-versus-host disease (GVHD) is the major complication after allogeneic stem cell transplantation (SCT). Emerging evidence indicates that GVHD leads to injury of intestinal stem cells. However, it remains to be investigated whether skin stem cells could be targeted in skin GVHD. Lgr5+ hair follicle stem cells (HFSCs) contribute to folliculogenesis and have a multipotent capacity to regenerate all epithelial cells in repair. We studied the fate of Lgr5+ HFSCs after SCT and explored the novel treatment to protect Lgr5+ HFSCs against GVHD using murine models of SCT...
January 23, 2018: Blood
https://www.readbyqxmd.com/read/29317265/wound-regeneration-deficit-in-rats-correlates-with-low-morphogenetic-potential-and-distinct-transcriptome-profile-of-epidermis
#5
Christian F Guerrero-Juarez, Aliaksandr A Astrowski, Rabi Murad, Christina T Dang, Vera O Shatrova, Aksana Astrowskaja, Chae Ho Lim, Raul Ramos, Xiaojie Wang, Yuchen Liu, Hye-Lim Lee, Kim T Pham, Tsai-Ching Hsi, Ji Won Oh, Daniel Crocker, Ali Mortazavi, Mayumi Ito, Maksim V Plikus
Large excisional wounds in mice prominently regenerate new hair follicles (HFs) and fat, yet humans are deficient for this regenerative behavior. Currently, wound-induced regeneration remains a clinically desirable, but only partially understood phenomenon. We show that large excisional wounds in rats, across seven strains fail to regenerate new HFs. We compared wound transcriptomes between mice and rats at the time of scab detachment, which coincides with the onset of HF regeneration in mice. In both species, wound dermis and epidermis share core dermal and epidermal transcriptional programs respectively, yet prominent inter-species differences exist...
January 6, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29316829/effects-of-carbomer-940-hydrogel-on-burn-wounds-an-in-vitro-and-in-vivo-study
#6
Farzad Hayati, Seyed Mehdi Ghamsari, Mohammad Mehdi Dehghan, Ahmad Oryan
PURPOSE: This study was designed to investigate the applicability of carbomer 940 hydrogel on skin-burn wounds by focusing on its effects on the zone of stasis. METHOD: Fibroblast cells were used to assess the cytotoxicity of carbomer 940. Wound healing was monitored by laser Doppler flowmetry and histopathological analysis. Twenty adult male Wistar rats were randomly divided into two groups (N = 10 each). After shaving their dorsum, a "burn comb" was contacted bilaterally on each side of the spine...
January 10, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29310861/never-too-old-to-regenerate-wound-induced-hair-follicle-neogenesis-after-secondary-intention-healing-in-a-geriatric-patient
#7
Tak-Wah Wong, Michael Hughes, Szu-Han Wang
Wound healing is a natural process to restore the structure and function of injured or diseased tissues. Repair of a skin wound usually leads to a scar while regeneration implies fully recovery of function and structure of the damaged tissue. Adult skin wound usually heals with scar while fetal skin heals scarless. Hair regeneration in elderly scalp wound has never been observed. We reported an 80-year-old patient with a large wound on the scalp after excision of a basal cell carcinoma healed by secondary intention wound healing...
January 4, 2018: Journal of Tissue Viability
https://www.readbyqxmd.com/read/29244903/dermal-fibroblast-in-cutaneous-development-and-healing
#8
REVIEW
Venkata Thulabandu, Demeng Chen, Radhika P Atit
The skin is the largest organ of the body and is composed of two layers: the overlying epidermis and the underlying dermis. The dermal fibroblasts originate from distinct locations of the embryo and contain the positional identity and patterning information in the skin. The dermal fibroblast progenitors differentiate into various cell types that are fated to perform specific functions such as hair follicle initiation and scar formation during wound healing. Recent studies have revealed the heterogeneity and plasticity of dermal fibroblasts within skin, which has implications for skin disease and tissue engineering...
December 15, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/29201190/pigment-epithelium-derived-factor-short-peptides-facilitate-full-thickness-cutaneous-wound-healing-by-promoting-epithelial-basal-cell-and-hair-follicle-stem-cell-proliferation
#9
Shawn H Tsai, Li-Pen Tsao, Shih-Hsin Chang, Tsung-Chuan Ho, Kwang-Yi Tung, Ai-Ching Wu, Yeou-Ping Tsao
A previous study by our group showed that a 44-amino-acid fragment of pigment epithelium-derived factor (PEDF) facilitated corneal epithelial wound healing. In the present study this fragment was shortened to obtain peptides of 18, 20 and 29 amino acids in length, and their promoting effects on the healing of full-thickness skin wounds were assessed. Peptides were delivered periodically by topical application to punch wounds of mice. The wound healing speed was evaluated by measuring the reduction of wound areas at 4 and 7 days after injury...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29199946/stimulation-of-hair-follicle-stem-cell-proliferation-through-an-il-1-dependent-activation-of-%C3%AE-%C3%AE-t-cells
#10
Pedro Lee, Rupali Gund, Abhik Dutta, Neha Pincha, Isha Rana, Subhasri Ghosh, Deborah Witherden, Eve Kandyba, Amanda MacLeod, Krzysztof Kobielak, Wendy L Havran, Colin Jamora
The cutaneous wound-healing program is a product of a complex interplay among diverse cell types within the skin. One fundamental process that is mediated by these reciprocal interactions is the mobilization of local stem cell pools to promote tissue regeneration and repair. Using the ablation of epidermal caspase-8 as a model of wound healing in Mus musculus, we analyzed the signaling components responsible for epithelial stem cell proliferation. We found that IL-1α and IL-7 secreted from keratinocytes work in tandem to expand the activated population of resident epidermal γδT-cells...
December 4, 2017: ELife
https://www.readbyqxmd.com/read/29173159/antioxidant-potential-and-wound-healing-activity-of-biosurfactant-produced-by-acinetobacter-junii-b6
#11
Mandana Ohadi, Hamid Forootanfar, Hamid Reza Rahimi, Elham Jafari, Mojtaba Shakibaie, Touba Eslaminejad, Gholamreza Dehghannoudeh
BACKGROUND: Recently, the development of a safe bioactive material with antioxidant properties, in which can improve healing activity are focusing. Biosurfactants are very famous for their antimicrobial and free radical scavenging activities. Thereof, the main aim of the present study was to investigate the antioxidant and wound healing activity of the lipopeptide biosurfactant (LBS) produced by Acinetobacter junii B6. DPPH radical scavenging activities and FRAP assays were used to measure the antioxidant properties...
November 22, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29115537/lncrna-plncrna%C3%A2-1-regulates-proliferation-and-differentiation-of-hair-follicle-stem-cells-through-tgf%C3%A2-%C3%AE-1%C3%A2-mediated-wnt-%C3%AE-%C3%A2-catenin-signal-pathway
#12
Yuan Si, Jingzhu Bai, Jiang Wu, Qun Li, You Mo, Ruihua Fang, Wei Lai
The present study demonstrated that hair follicle stem cells (HFSc) have multidirectional differentiation potential and participate in skin wound healing processes. Long non‑coding RNAs (lncRNAs) are defined as non‑protein coding transcripts longer than 200 nucleotides, which are important in the proliferation and differentiation of cells. The purpose of the present study was to investigate the role of PlncRNA‑1 in the proliferation and differentiation of HFSc. Results revealed that PlncRNA‑1, transforming growth factor (TGF)‑β1, Wnt and β‑catenin expression levels were significantly downregulated in HFSc...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29106928/epithelial-mesenchymal-stem-cell-transition-in-a-human-organ-lessons-from-lichen-planopilaris
#13
H Imanishi, D M Ansell, J Chéret, M Harries, M Bertolini, N Sepp, T Bíró, E Poblet, F Jimenez, J Hardman, S Parameswara Panicker, C M Ward, R Paus
Epithelial-to-mesenchymal transition (EMT) is critical for embryonic development and wound healing, and occurs in fibrotic disease and carcinoma. Here, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of human scalp hair follicles (HFs), during the inflammatory permanent alopecia, lichen planopilaris (LPP). We show that a molecular EMT signature can be experimentally induced in healthy human eSCs in situ by antagonizing E-cadherin, combined with TGF-ß1, EGF, and interferon-γ administration, which to our knowledge is previously unreported...
October 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29079536/restoration-of-skin-pigmentation-after-deep-partial-or-full-thickness-burn-injury
#14
REVIEW
Niann-Tzyy Dai, Hsin-I Chang, Yi-Wen Wang, Keng-Yen Fu, Tai-Chun Huang, Nien-Chi Huang, Jhen-Kai Li, Pai-Shan Hsieh, Lien-Guo Dai, Chao-Kuei Hsu, Peter K Maitz
Significant skin pigmentation changes occur when patients suffer deep burn injuries. These pigmentation disorders may cause not only cosmetic and psychological issues, but more importantly it increases the risk of skin cancer or photoaging. Severe burns significantly effect on the process of repigmentation as the pigmentation is tightly regulated by cell proliferation and differentiation of melanocytes and melanocyte stem cells which are housing in the epidermis and hair follicles of the skin. In the present review, we discuss the possible mechanisms to replenish the melanocytes from the healthy epidermis and hair follicles surrounding burn wounds...
January 1, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28933697/enhanced-skin-regeneration-using-a-novel-amniotic-derived-tissue-graft
#15
Katie C Mowry, Paul P Bonvallet, Susan L Bellis
BACKGROUND: Chronic and recalcitrant wounds present a significant therapeutic challenge. Amniotic tissues contain many regenerative cytokines, growth factors, and extracellular matrix molecules including proteoglycans, hyaluronic acid, and collagens I, III, and IV. Dehydrated amnion/chorion grafts are currently used to treat a variety of wounds such as diabetic foot ulcers and burns. OBJECTIVE: The investigators hypothesized that processing methodologies, dehydration, and hypothermic processing and storage of amniotic tissues would affect overall quality of wound healing; they compared dehydrated amnion/chorion (dHACM) grafts to a novel hypothermically stored amniotic membrane (HSAM) graft in a full-thickness rat wound model...
September 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28922518/accelerated-epithelialization-and-improved-wound-healing-metrics-in-porcine-full-thickness-wounds-transplanted-with-full-thickness-skin-micrografts
#16
Christina L Rettinger, John L Fletcher, Anders H Carlsson, Rodney K Chan
Split-thickness skin grafting (STSG) is the current gold standard for treatment of extensive burn and traumatic skin injuries. However, STSG is limited by donor-site morbidity and availability, and often leads to scarring and wound contracture. Furthermore, these thin grafts lack dermal elements such as nerves and adnexa which are important in recapitulating normal skin function. Methods of fractional skin replacement either as minced STSGs or microscopic skin tissue columns have been proposed, though these techniques have not been fully characterized and lack evidence of regenerated adnexal structures...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28918904/comparison-of-laser-doppler-imaging-ldi-and-clinical-assessment-in-differentiating-between-superficial-and-deep-partial-thickness-burn-wounds
#17
Saadia Nosheen Jan, Farid Ahmed Khan, Muhammad Mustehsan Bashir, Muneeb Nasir, Hamid Hussain Ansari, Hussan Birkhez Shami, Umer Nazir, Asif Hanif, Muhammad Sohail
PURPOSE OF PRESENTATION/STUDY: To compare the accuracy of Laser Doppler Imaging (LDI) and clinical assessment in differentiating between superficial and deep partial thickness burns to decide whether early tangential excision and grafting or conservative management should be employed to optimize burn and patient management. STUDY PERIOD: March 2015 to November 2016. METHODS/PROCEDURE DETAILS: Ninety two wounds in 34 patients reporting within 5days of less than 40% burn surface area were included...
September 14, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28912581/secretory-phospholipase-a2-iia-overexpressing-mice-exhibit-cyclic-alopecia-mediated-through-aberrant-hair-shaft-differentiation-and-impaired-wound-healing-response
#18
Gopal L Chovatiya, Rahul M Sarate, Raghava R Sunkara, Nilesh P Gawas, Vineet Kala, Sanjeev K Waghmare
Secretory phospholipase A2 Group-IIA (sPLA2-IIA) is involved in lipid catabolism and growth promoting activity. sPLA2-IIA is deregulated in many pathological conditions including various cancers. Here, we have studied the role of sPLA2-IIA in the development of cyclic alopecia and wound healing response in relation to complete loss of hair follicle stem cells (HFSCs). Our data showed that overexpression of sPLA2-IIA in homozygous mice results in hyperproliferation and terminal epidermal differentiation followed by hair follicle cycle being halted at anagen like stage...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887865/platelet-rich-plasma-the-ultimate-secret-for-youthful-skin-elixir-and-hair-growth-triggering
#19
REVIEW
Ebtisam Elghblawi
The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage...
September 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28823088/electrical-signals-triggered-controllable-formation-of-calcium-alginate-film-for-wound-treatment
#20
Xiaoli Liu, Huan Liu, Xue Qu, Miao Lei, Chuchu Zhang, Hua Hong, Gregory F Payne, Changsheng Liu
Wound dressings play important roles in the management of wounds, and calcium cross-linked alginate (Ca(2+)-Alg) is a commonly used hydrogel that is adapted for wound treatment. However, conventional methods for fabricating Ca(2+)-Alg hydrogels can be tedious and difficult to control because of the rapid Ca(2+)-induced gelation of alginate. In this study, An electrodeposition method was used to rapidly and controllably fabricate Ca(2+)-Alg films for wound treatment. Several measures of film growth (e.g., thickness and mass) are shown to linearly correlate to the imposed charge transfer at the electrode...
August 19, 2017: Journal of Materials Science. Materials in Medicine
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