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https://www.readbyqxmd.com/read/28316170/-advances-in-effects-of-integrin-linked-kinase-on-cutaneous-wound-healing-and-the-relative-mechanism
#1
R X Zhou, Y Y Li, W H Lin, G Li, J E Sun, W B Zhou
Previous studies have demonstrated that integrin-linked kinases (ILKs) are abundantly expressed in extracellular matrix (ECM) riche dermis, hair follicles, and basal cells of epidermis. ILKs are not only essential for the maintenance of skin structure, but also play important roles in wound healing. ILKs can promote the formation of granulation tissue by stimulating the proliferation of fibroblasts and secretion of ECM, accelerate wound contraction by inducing the differentiation of fibroblasts to myofibroblasts, and boost reepithelization by promoting proliferation, migration, and differentiation of keratinocytes and follicle epidermal stem cells...
March 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28212278/the-effect-of-the-human-peptide-ghk-on-gene-expression-relevant-to-nervous-system-function-and-cognitive-decline
#2
Loren Pickart, Jessica Michelle Vasquez-Soltero, Anna Margolina
Neurodegeneration, the progressive death of neurons, loss of brain function, and cognitive decline is an increasing problem for senior populations. Its causes are poorly understood and therapies are largely ineffective. Neurons, with high energy and oxygen requirements, are especially vulnerable to detrimental factors, including age-related dysregulation of biochemical pathways caused by altered expression of multiple genes. GHK (glycyl-l-histidyl-l-lysine) is a human copper-binding peptide with biological actions that appear to counter aging-associated diseases and conditions...
February 15, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28106913/efficacy-of-50%C3%A2-hz-electromagnetic-fields-on-human-epidermal-stem-cell-transplantation-seeded-in-collagen-sponge-scaffolds-for-wound-healing-in-a-murine-model
#3
Wen-Fang Bai, Wei-Cheng Xu, Hong-Xiang Zhu, Hong Huang, Bo Wu, Ming-Sheng Zhang
To explore the possible efficacy of electromagnetic fields (EMF) for skin tissue engineering, effects of EMF exposure on epidermal stem cells (ESC) seeded in collagen sponge scaffolds for wound healing in a murine model were investigated. The wound models of a full-thickness defect established with 36 7 ∼ 8-week-old nude mice were randomly divided into three groups: a control group, an ESC-only group, and an ESC with EMF exposure group (frequency of 50 Hz, magnetic induction of 5 mT, 60 min per day for 20 days)...
April 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28094870/igf1r-signaling-acts-on-the-anagen-to-catagen-transition-in-the-hair-cycle
#4
Mathieu Castela, Fabien Linay, Edwige Roy, Philippe Moguelet, Jie Xu, Martin Holzenberger, Kiarash Khosrotehrani, Selim Aractingi
Insulin like growth factor 1 (IGF1) is important for skin development and homeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the IGF1 receptor (IGF1R) in keratin 15-expressing bulge cells. Deletion of IGF1R after the development of the skin appendages in K15-IGF1R(KO) mice showed no abnormalities in epidermal homeostasis. Numbers of bulge cells were lower in K15-IGF1R(KO) mice than in controls, without consequences on wound healing, at least in young mice...
January 17, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28059714/regeneration-of-fat-cells-from-myofibroblasts-during-wound-healing
#5
Maksim V Plikus, Christian F Guerrero-Juarez, Mayumi Ito, Yun Rose Li, Priya H Dedhia, Ying Zheng, Mengle Shao, Denise L Gay, Raul Ramos, Tsai-Ching Hsi, Ji Won Oh, Xiaojie Wang, Amanda Ramirez, Sara E Konopelski, Arijh Elzein, Anne Wang, Rarinthip June Supapannachart, Hye-Lim Lee, Chae Ho Lim, Arben Nace, Amy Guo, Elsa Treffeisen, Thomas Andl, Ricardo N Ramirez, Rabi Murad, Stefan Offermanns, Daniel Metzger, Pierre Chambon, Alan D Widgerow, Tai-Lan Tuan, Ali Mortazavi, Rana K Gupta, Bruce A Hamilton, Sarah E Millar, Patrick Seale, Warren S Pear, Mitchell A Lazar, George Cotsarelis
Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation...
February 17, 2017: Science
https://www.readbyqxmd.com/read/28042321/pre-vascularization-enhances-therapeutic-effects-of-human-mesenchymal-stem-cell-sheets-in-full-thickness-skin-wound-repair
#6
Lei Chen, Qi Xing, Qiyi Zhai, Mitchell Tahtinen, Fei Zhou, Lili Chen, Yingbin Xu, Shaohai Qi, Feng Zhao
Split thickness skin graft (STSG) implantation is one of the standard therapies for full thickness wound repair when full thickness autologous skin grafts (FTG) or skin flap transplants are inapplicable. Combined transplantation of STSG with dermal substitute could enhance its therapeutic effects but the results remain unsatisfactory due to insufficient blood supply at early stages, which causes graft necrosis and fibrosis. Human mesenchymal stem cell (hMSC) sheets are capable of accelerating the wound healing process...
2017: Theranostics
https://www.readbyqxmd.com/read/27976527/skin-regeneration-with-all-accessory-organs-following-ablation-with-irreversible-electroporation
#7
Alexander Golberg, Martin Villiger, G Felix Broelsch, Kyle P Quinn, Hassan Albadawi, Saiqa Khan, Michael T Watkins, Irene Georgakoudi, William G Austen, Marianna Bei, Brett E Bouma, Martin C Mihm, Martin L Yarmush
Skin scar formation is a complex process that results in the formation of dense extracellular matrix without normal skin appendages such as hair and glands. The absence of a scarless healing model in adult mammals prevents the development of successful therapies. We show that irreversible electroporation of skin drives its regeneration with all accessory organs in normal adult rats. Pulsed electric fields at 500 V, with 70 µs pulse duration, and 1000 pulses delivered at 3 Hz, applied through two electrodes separated by 2 mm lead to massive cell death...
December 14, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27898044/dna-damage-inducible-transcript-4-is-an-innate-surveillant-of-hair-follicular-stress-in-vitamin-d-receptor-knockout-mice-and-a-regulator-of-wound-re-epithelialization
#8
Hengguang Zhao, Sandra Rieger, Koichiro Abe, Martin Hewison, Thomas S Lisse
Mice and human patients with impaired vitamin D receptor (VDR) signaling have normal developmental hair growth but display aberrant post-morphogenic hair cycle progression associated with alopecia. In addition, VDR(-/-) mice exhibit impaired cutaneous wound healing. We undertook experiments to determine whether the stress-inducible regulator of energy homeostasis, DNA damage-inducible transcript 4 (Ddit4), is involved in these processes. By analyzing hair cycle activation in vivo, we show that VDR(-/-) mice at day 14 exhibit increased Ddit4 expression within follicular stress compartments...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27745629/hair-follicle-containing-punch-grafts-accelerate-chronic-ulcer-healing-a-randomized-controlled-trial
#9
María-Luisa Martínez, Eduardo Escario, Enrique Poblet, David Sánchez, Fernando-Francisco Buchón, Ander Izeta, Francisco Jimenez
BACKGROUND: A prominent role of hair follicle-derived cells in epidermal wound closure is now well established but clinical translation of basic research findings is scarce. Although skin punch grafts have been used as a therapeutic intervention to improve healing of chronic leg ulcers, they are normally harvested from nonhairy areas, thus not taking advantage of the reported role of the hair follicle as a wound-healing promoter. OBJECTIVE: We sought to substantiate the role of hair follicles in venous leg ulcer healing by transplanting hair follicle-containing versus nonhairy punch grafts...
November 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27679975/multifaceted-role-of-hair-follicle-dermal-cells-in-bioengineered-skins
#10
C A Higgins, M Roger, R Hill, A S Ali-Khan, J Garlick, A M Christiano, C A B Jahoda
BACKGROUND: The method to generate bioengineered skin constructs was pioneered several decades ago, and nowadays these constructs are used regularly for the treatment of severe burns and non-healing wounds. Commonly, these constructs are comprised of skin fibroblasts within a collagen scaffold, forming the skin dermis, and stratified keratinocytes overlying this, forming the skin epidermis. In the past decade there has been a surge of interest in bioengineered skins, with researchers searching for alternative cell sources, or scaffolds, from which constructs can be established, and for more biomimetic equivalents with skin appendages...
September 28, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27676122/two-photon-microscopy-for-intracutaneous-imaging-of-stem-cell-activity-in-mice
#11
REVIEW
Sixia Huang, Panteleimon Rompolas
The adult skin is a typical example of a highly regenerative tissue. Terminally differentiated keratinocytes are shed from the external layers of the epidermis or extruded from the skin as part of the growing hair shaft on a daily basis. These are effectively replenished through the activity of skin-resident stem cells. Precise regulation of stem cell activity is critical for normal skin homoeostasis or wound healing and irregular stem cell proliferation or differentiation can lead to skin disease. The scarcity and dynamic nature of stem cells presents a major challenge for elucidating their mechanism of action...
September 27, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27612816/antibacterial-performance-and-in-vivo-diabetic-wound-healing-of-curcumin-loaded-gum-tragacanth-poly-%C3%AE%C2%B5-caprolactone-electrospun-nanofibers
#12
Marziyeh Ranjbar-Mohammadi, Shahram Rabbani, S Hajir Bahrami, M T Joghataei, F Moayer
In this study we describe the potential of electrospun curcumin-loaded poly(ε-caprolactone) (PCL)/gum tragacanth (GT) (PCL/GT/Cur) nanofibers for wound healing in diabetic rats. These scaffolds with antibacterial property against methicillin resistant Staphylococcus aureus as gram positive bacteria and extended spectrum β lactamase as gram negative bacteria were applied in two forms of acellular and cell-seeded for assessing their capability in healing full thickness wound on the dorsum of rats. After 15days, pathological study showed that the application of GT/PCL/Cur nanofibers caused markedly fast wound closure with well-formed granulation tissue dominated by fibroblast proliferation, collagen deposition, complete early regenerated epithelial layer and formation of sweat glands and hair follicles...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27597871/hair-follicle-morphogenesis-in-the-treatment-of-mouse-full-thickness-skin-defects-using-composite-human-acellular-amniotic-membrane-and-adipose-derived-mesenchymal-stem-cells
#13
Wu Minjuan, Xiong Jun, Shao Shiyun, Xu Sha, Ni Haitao, Wang Yue, Ji Kaihong
Early repair of skin injury and maximal restoration of the function and appearance have become important targets of clinical treatment. In the present study, we observed the healing process of skin defects in nude mice and structural characteristics of the new skin after transplantation of isolated and cultured adipose derived mesenchymal stem cells (ADMSCs) onto the human acellular amniotic membrane (AAM). The result showed that ADMSCs were closely attached to the surface of AAM and grew well 24 h after seeding...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27595936/flightless-i-expression-enhances-murine-claw-regeneration-following-digit-amputation
#14
Xanthe L Strudwick, James M Waters, Allison J Cowin
The mammalian digit tip is capable of both reparative and regenerative wound healing dependent on the level of amputation injury. Removal of the distal third of the terminal phalange results in successful regeneration, whereas a more severe, proximal, amputation heals by tissue repair. Flightless I (Flii) is involved in both tissue repair and regeneration. It negatively regulates wound repair but elicits a positive effect in hair follicle regeneration, with Flii overexpression resulting in significantly longer hair fibers...
January 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27499879/ear-wound-regeneration-in-the-african-spiny-mouse-acomys-cahirinus
#15
Dino Matias Santos, Ana Martins Rita, Ignasi Casanellas, Adélia Brito Ova, Inês Maria Araújo, Deborah Power, Gustavo Tiscornia
While regeneration occurs in a number of taxonomic groups across the Metazoa, there are very few reports of regeneration in mammals, which generally respond to wounding with fibrotic scarring rather than regeneration. A recent report described skin shedding, skin regeneration and extensive ear punch closure in two rodent species, Acomys kempi and Acomys percivali. We examined these striking results by testing the capacity for regeneration of a third species, Acomys cahirinus, and found a remarkable capacity to repair full thickness circular punches in the ear pinna...
February 2016: Regeneration
https://www.readbyqxmd.com/read/27498534/hidradenitis-suppurativa-a-case-series-of-eight-patients
#16
Momcilo Stosić, Igor Stojanović
INTRODUCTION: Hidradenitis suppurativa is a persistent, inflammatory and recurrent disease of the hair follicles which, in time, results in ugly scars. Inflammation and obstruction of channel of sweat glands used to be thought to be the basis of this disease. CASE REPORTS: This paper presents the cases of 8 patients operated on in the past 3 years. A possibility of an oversight in making the diagnosis, as well as an underestimation in the treatment should be taken into consideration...
January 2016: Medicinski Pregled
https://www.readbyqxmd.com/read/27427589/adult-stem-cells-seeded-on-electrospinning-silk-fibroin-nanofiberous-scaffold-enhance-wound-repair-and-regeneration
#17
Sheng-Yang Xie, Li-Hua Peng, Ying-Hui Shan, Jie Niu, Jie Xiong, Jian-Qing Gao
Development of novel strategy stimulating the healing with skin appendages regeneration is the critical goal for wound therapy. In this study, influence of the transplantation of bone marrow derived mesenchymal stem cells (MSCs) and epidermal stem cells (ESCs) with the nanofiberous scaffold prepared from silk fibroin protein in wound re-epithelization, collagen synthesis, as well as the skin appendages regeneration were investigated. It was shown that both the transplantation of MSCs and ESCs could significantly accelerate the skin re-epithelization, stimulate the collagen synthesis...
June 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27375744/epidermal-cells-expressing-putative-cell-markers-in-nonglabrous-skin-existing-in-direct-proximity-with-the-distal-end-of-the-arrector-pili-muscle
#18
N Torkamani, N W Rufaut, L Jones, R Sinclair
Inconsistent with the view that epidermal stem cells reside randomly spread along the basal layer of the epidermal rete ridges, we found that epidermal cells expressing stem cell markers in nonglabrous skin exist in direct connection with the distal end of the arrector pili muscle. The epidermal cells that express stem cell markers consist of a subpopulation of basal keratinocytes located in a niche at the lowermost portion of the rete ridges at the distal arrector pili muscle attachment site. Keratinocytes in the epidermal stem cell niche express K15, MCSP, and α6 integrin...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27371823/tissue-injury-and-repair-following-cutaneous-exposure-of-mice-to-sulfur-mustard
#19
Laurie B Joseph, Gabriella M Composto, Diane E Heck
In mouse skin, sulfur mustard (SM) is a potent vesicant, damaging both the epidermis and the dermis. The extent of wounding is dependent on the dose of SM and the duration of exposure. Initial responses include erythema, pruritus, edema, and xerosis; this is followed by an accumulation of inflammatory leukocytes in the tissue, activation of mast cells, and the release of mediators, including proinflammatory cytokines and bioactive lipids. These proinflammatory mediators contribute to damaging the epidermis, hair follicles, and sebaceous glands and to disruption of the epidermal basement membrane...
August 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27265328/defining-the-identity-of-mouse-embryonic-dermal-fibroblasts
#20
Isadore Budnick, Emily Hamburg-Shields, Demeng Chen, Eduardo Torre, Andrew Jarrell, Batool Akhtar-Zaidi, Olivia Cordovan, Rob C Spitale, Peter Scacheri, Radhika P Atit
Embryonic dermal fibroblasts in the skin have the exceptional ability to initiate hair follicle morphogenesis and contribute to scarless wound healing. Activation of the Wnt signaling pathway is critical for dermal fibroblast fate selection and hair follicle induction. In humans, mutations in Wnt pathway components and target genes lead to congenital focal dermal hypoplasias with diminished hair. The gene expression signature of embryonic dermal fibroblasts during differentiation and its dependence on Wnt signaling is unknown...
August 2016: Genesis: the Journal of Genetics and Development
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