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https://www.readbyqxmd.com/read/28699278/regulatory-t-cells-in-skin
#1
REVIEW
Niwa Ali, Michael D Rosenblum
Foxp3+ CD4+ Regulatory T cells (Tregs) are a subset of immune cells that function to regulate tissue inflammation. Skin is one of the largest organs and is home to a large proportion of the body's Tregs. However, relative to other tissues (such as the spleen and gastrointestinal tract) the function of Tregs in skin is less well defined. Here, we review our understanding of how Tregs migrate to skin and the cellular and molecular pathways required for their maintenance in this tissue. In addition, we outline what is known about the specialized functions of Tregs in skin...
July 12, 2017: Immunology
https://www.readbyqxmd.com/read/28697631/recent-advances-on-biomedical-applications-of-scaffolds-in-wound-healing-and-dermal-tissue-engineering
#2
Azizeh Rahmani Del Bakhshayesh, Nasim Annabi, Rovshan Khalilov, Abolfazl Akbarzadeh, Mohammad Samiei, Effat Alizadeh, Mohammadreza Alizadeh-Ghodsi, Soodabeh Davaran, Azadeh Montaseri
The tissue engineering field has developed in response to the shortcomings related to the replacement of the tissues lost to disease or trauma: donor tissue rejection, chronic inflammation and donor tissue shortages. The driving force behind the tissue engineering is to avoid the mentioned issues by creating the biological substitutes capable of replacing the damaged tissue. This is done by combining the scaffolds, cells and signals in order to create the living, physiological, three-dimensional tissues. A wide variety of skin substitutes are used in the treatment of full-thickness injuries...
July 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28680144/transplanted-adipose-derived-stem-cells-can-be-short-lived-yet-accelerate-healing-of-acid-burn-skin-wounds-a-multimodal-imaging-study
#3
Ghulam Muhammad, Jiadi Xu, Jeff W M Bulte, Anna Jablonska, Piotr Walczak, Miroslaw Janowski
The incidence of accidental and intentional acid skin burns is rising. Current treatment strategies are mostly inadequate, leaving victims disfigured and without treatment options. Here, we have shown that transplantation of adipose-derived stem cells (ASCs) accelerates the process of acid burn wound-healing. Pre-conditioning of ASCs using ascorbic acid (AA) or hypoxic conditions provided additional benefit. While the wounds were ultimately healed in all mice, histological analysis revealed that, in non-transplanted animals, the number of hair follicles was reduced...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677234/anti-aging-pharmacology-in-cutaneous-wound-healing-effects-of-metformin-resveratrol-and-rapamycin-by-local-application
#4
Pan Zhao, Bing-Dong Sui, Nu Liu, Ya-Jie Lv, Chen-Xi Zheng, Yong-Bo Lu, Wen-Tao Huang, Cui-Hong Zhou, Ji Chen, Dan-Lin Pang, Dong-Dong Fei, Kun Xuan, Cheng-Hu Hu, Yan Jin
Cutaneous wounds are among the most common soft tissue injuries and are particularly hard to heal in aging. Caloric restriction (CR) is well documented to extend longevity; pharmacologically, profound rejuvenative effects of CR mimetics have been uncovered, especially metformin (MET), resveratrol (RSV), and rapamycin (RAPA). However, locally applied impacts and functional differences of these agents on wound healing remain to be established. Here, we discovered that chronic topical administration of MET and RSV, but not RAPA, accelerated wound healing with improved epidermis, hair follicles, and collagen deposition in young rodents, and MET exerted more profound effects...
July 5, 2017: Aging Cell
https://www.readbyqxmd.com/read/28655873/synergistic-effect-of-human-bone-morphogenic-protein-2-and-mesenchymal-stromal-cells-on-chronic-wounds-through-hypoxia-inducible-factor-1-%C3%AE-induction
#5
Sabine François, Véronique V Eder, Karim Belmokhtar, Marie-Christine Machet, Luc Douay, Norbert-Claude Gorin, Marc Benderitter, Chapel A Alain
Chronic skin ulcers and burns require advanced treatments. Mesenchymal Stromal Cells (MSCs) are effective in treating these pathologies. Bone Morphogenic Protein-2 (BMP-2) is known to enhance angiogenesis. We investigated whether recombinant human hBMP-2 potentiates the effect of MSCs on wound healing. Severe ulceration was induced in rats by irradiation and treated by co-infusion of MSCs with hBMP-2 into the ulcerated area which accelerated wound healing. Potentiation of the effect of MSCs by hBMP-2 on endothelial repair improved skin healing...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28607955/wound-healing-protects-against-chemotherapy-induced-alopecia-in-young-rats-via-up-regulating-interleukin-1%C3%AE-mediated-signaling
#6
Olivera Stojadinovic, Tongyu C Wikramanayake, Alexandra C Villasante Fricke, Natalie C Yin, Liang Liang, Eleanor Hinde, Julia Escandon, Marjana Tomic-Canic, David M Ansell, Ralf Paus, Joaquin J Jimenez
Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whether the wound healing-associated signaling milieu can be manipulated to protect against alopecia, such as chemotherapy-induced alopecia (CIA). Utilizing a well-established neonatal rat model of CIA, we show here that skin wounding protects from alopecia caused by several clinically relevant chemotherapeutic regimens, and that protection is dependent on the time of wounding and hair cycle stage...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28552069/tissue-engineered-skin-and-wound-healing-current-strategies-and-future-directions
#7
Nandana Bhardwaj, Dimple Chouhan, Biman B Mandal
The global volume of skin damage or injuries has major healthcare implications and, accounts for about half of the world's annual expenditure in the healthcare sector. In the last two decades, tissue-engineered skin constructs have shown great promise in the treatment of various skin-related disorders such as deep burns and wounds. The treatment methods for skin replacement and repair have evolved from utilization of autologous epidermal sheets to more complex bilayered cutaneous tissue engineered skin substitutes...
May 25, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28513105/hair-follicle-specific-acvr1-alk2-critically-affects-skin-morphogenesis-and-attenuates-wound-healing
#8
Michael Sorkin, Shailesh Agarwal, Kavitha Ranganathan, Shawn Loder, David Cholok, David Fireman, John Li, Shuli Li, Bin Zhao, Yuji Mishina, Paul Cederna, Benjamin Levi
The bone morphogenic protein signaling (BMP) is intricately involved in the quiescence and regulation of stem cells through activation of BMP receptors. Hair follicle stem cells play a critical role in cutaneous homeostasis and regeneration. Here, we utilize a novel mouse model with targeted overexpression of the BMP receptor ALK2/ACVR1 in hair follicle stem cells, to characterize its role in skin development and postnatal wound healing. Initial histologic evaluation demonstrated significant dysregulation in hair follicle morphogenesis in mutant mice...
May 17, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28480384/evaluation-of-effectiveness-in-a-novel-wound-healing-ointment-crocodile-oil-burn-ointment
#9
Hua-Liang Li, Yi-Tao Deng, Zi-Ran Zhang, Qi-Rui Fu, Ya-Hui Zheng, Xing-Mei Cao, Jing Nie, Li-Wen Fu, Li-Ping Chen, You-Xiong Xiong, Dong-Yan Shen, Qing-Xi Chen
BACKGROUND: Crocodile oil and its products are used as ointments for burns and scalds in traditional medicines. A new ointment formulation - crocodile oil burn ointment (COBO) was developed to provide more efficient wound healing activity. The purpose of the study was to evaluate the burn healing efficacy of this new formulation by employing deep second-degree burns in a Wistar rat model. The analgesic and anti-inflammatory activities of COBO were also studied to provide some evidences for its further use...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28470226/flexible-and-highly-interconnected-multi-scale-patterned-chitosan-porous-membrane-produced-in-situ-from-mussel-shell-to-accelerate-wound-healing
#10
Xiaoping Song, Jie Mei, Xingying Zhang, Leyu Wang, Gurankit Singh, Malcolm M Q Xing, Xiaozhong Qiu
Utilization of the underlying mechanisms of biological systems is the principal endeavor of biomimetics, the primary goal of which is to treat on-going biological processes. From the perspective of tissue engineering, one purpose of biomimetics is to create highly cellular- or tissue-favored environments for bio-defect repair. Marine creatures such as mussels have inspired bioengineers to design ideal cellular substrates, strong adhesives, and other bioengineering materials. Herein, we report a novel mussel shell-derived membrane for wound dressing...
May 30, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28438262/hair-follicle-transplant-into-chronic-ulcers-a-new-graft-concept
#11
M L Martínez Martínez, E Escario Travesedo, F Jiménez Acosta
Chronic venous leg ulcers are a major therapeutic challenge in clinical practice, and the search for new approaches to improve wound healing is essential. Many ulcers do not heal with traditional treatment using compression, debridement, and dressings. Skin-grafts variants, such as pinch grafts, punch grafts, split- or full-thickness skin grafts, and grafts derived from cells cultured in the laboratory, are among the most widely used options in ulcers that do not heal. In recent years, numerous studies have brought to our attention the important role of the hair follicle in the healing process of cutaneous wounds...
July 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28427959/beneficial-effects-of-heparin-and-l-arginine-on-dermonecrosis-effect-induced-by-vipera-lebetina-venom-involvement-of-no-in-skin-regeneration
#12
Nouara Bennacef-Heffar, Fatima Laraba-Djebari
It is well known that snake venoms such as Viperidae caused severe local effects such as hemorrhage, myonecrosis and dermonecrosis which can lead to permanent tissue loss or the disability. The aim of this study is to evaluate the skin regeneration using heparin and l-arginine as well as the dermonecrotic effects induced by Vipera lebetina venom (VLV). To better understand the toxic effects induced by VLV and to prevent or treat these effects, we evaluate the local effects and the skin regeneration with or without drugs...
April 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28423680/a-bioartificial-dermal-regeneration-template-promotes-skin-cell-proliferation-in-vitro-and-enhances-large-skin-wound-healing-in-vivo
#13
Peng Chang, Bingyu Guo, Qiang Hui, Xiaoyan Liu, Kai Tao
A novel bioartificial dermal regeneration template has been developed using platelet-rich plasma and acellular animal skin collagen sponge for the treatment of larger area and full thickness skin wounds. This platelet-rich plasma-collagen sponge keeps native skin structure and contains huge amounts of growth factors. The effect of this bioartificial dermal regeneration template was tested in vitro and in vivo via a mimic poor wound healing process by adding collagenase I into cell culture medium or the wound area...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28368538/combined-deletion-of-the-vitamin-d-receptor-and-calcium-sensing-receptor-delays-wound-re-epithelialization
#14
Yuko Oda, Lizhi Hu, Thai Nguyen, Chak Fong, Chia-Ling Tu, Daniel D Bikle
When the skin is injured, keratinocytes proliferate, migrate, and differentiate to regenerate the epidermis. We recently showed that ablation of the vitamin D receptor (Vdr) in keratinocytes delays wound re-epithelialization in mice also fed a low-calcium diet, implicating a cooperative role of Vdr and calcium signaling in this process. In this study, we examined the role of vitamin D and calcium signaling in wound healing by deleting their receptors, Vdr and the calcium-sensing receptor (Casr). Gene expression profiling of neonatal epidermis lacking both Vdr and Casr [Vdr and Casr double knockout (DKO)] specifically in keratinocytes revealed that DKO affects a number of pathways relevant to wound healing, including Vdr, β-catenin, and adherens junction (AJ) signaling...
June 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28351680/human-lung-fibroblast-derived-matrix-facilitates-vascular-morphogenesis-in-3d-environment-and-enhances-skin-wound-healing
#15
Ping Du, Muhammad Suhaeri, Sang Su Ha, Seung Ja Oh, Sang-Heon Kim, Kwideok Park
Extracellular matrix (ECM) is crucial to many aspects of vascular morphogenesis and maintenance of vasculature function. Currently the recapitulation of angiogenic ECM microenvironment is still challenging, due mainly to its diverse components and complex organization. Here we investigate the angiogenic potential of human lung fibroblast-derived matrix (hFDM) in creating a three-dimensional (3D) vascular construct. hFDM was obtained via decellularization of in vitro cultured human lung fibroblasts and analyzed via immunofluorescence staining and ELISA, which detect multiple ECM macromolecules and angiogenic growth factors (GFs)...
May 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28337222/a-conditioned-medium-of-umbilical-cord-mesenchymal-stem-cells-overexpressing-wnt7a-promotes-wound-repair-and-regeneration-of-hair-follicles-in-mice
#16
Liang Dong, Haojie Hao, Jiejie Liu, Dongdong Ti, Chuan Tong, Qian Hou, Meirong Li, Jingxi Zheng, Gang Liu, Xiaobing Fu, Weidong Han
Mesenchymal stem cells (MSCs) can affect the microenvironment of a wound and thereby accelerate wound healing. Wnt proteins act as key mediators of skin development and participate in the formation of skin appendages such as hair. The mechanisms of action of MSCs and Wnt proteins on skin wounds are largely unknown. Here, we prepared a Wnt7a-containing conditioned medium (Wnt-CM) from the supernatant of cultured human umbilical cord-MSCs (UC-MSCs) overexpressing Wnt7a in order to examine the effects of this CM on cutaneous healing...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28316170/-advances-in-effects-of-integrin-linked-kinase-on-cutaneous-wound-healing-and-the-relative-mechanism
#17
R X Zhou, Y Y Li, W H Lin, G Li, J E Sun, W B Zhou
Previous studies have demonstrated that integrin-linked kinases (ILKs) are abundantly expressed in extracellular matrix (ECM) riche dermis, hair follicles, and basal cells of epidermis. ILKs are not only essential for the maintenance of skin structure, but also play important roles in wound healing. ILKs can promote the formation of granulation tissue by stimulating the proliferation of fibroblasts and secretion of ECM, accelerate wound contraction by inducing the differentiation of fibroblasts to myofibroblasts, and boost reepithelization by promoting proliferation, migration, and differentiation of keratinocytes and follicle epidermal stem cells...
March 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28212278/the-effect-of-the-human-peptide-ghk-on-gene-expression-relevant-to-nervous-system-function-and-cognitive-decline
#18
Loren Pickart, Jessica Michelle Vasquez-Soltero, Anna Margolina
Neurodegeneration, the progressive death of neurons, loss of brain function, and cognitive decline is an increasing problem for senior populations. Its causes are poorly understood and therapies are largely ineffective. Neurons, with high energy and oxygen requirements, are especially vulnerable to detrimental factors, including age-related dysregulation of biochemical pathways caused by altered expression of multiple genes. GHK (glycyl-l-histidyl-l-lysine) is a human copper-binding peptide with biological actions that appear to counter aging-associated diseases and conditions...
February 15, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28106913/efficacy-of-50%C3%A2-hz-electromagnetic-fields-on-human-epidermal-stem-cell-transplantation-seeded-in-collagen-sponge-scaffolds-for-wound-healing-in-a-murine-model
#19
Wen-Fang Bai, Wei-Cheng Xu, Hong-Xiang Zhu, Hong Huang, Bo Wu, Ming-Sheng Zhang
To explore the possible efficacy of electromagnetic fields (EMF) for skin tissue engineering, effects of EMF exposure on epidermal stem cells (ESC) seeded in collagen sponge scaffolds for wound healing in a murine model were investigated. The wound models of a full-thickness defect established with 36 7 ∼ 8-week-old nude mice were randomly divided into three groups: a control group, an ESC-only group, and an ESC with EMF exposure group (frequency of 50 Hz, magnetic induction of 5 mT, 60 min per day for 20 days)...
April 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28094870/igf1r-signalling-acts-on-the-anagen-to-catagen-transition-in-the-hair-cycle
#20
Mathieu Castela, Fabien Linay, Edwige Roy, Philippe Moguelet, Jie Xu, Martin Holzenberger, Kiarash Khosrotehrani, Selim Aractingi
Insulin-like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor (Igf1r) in keratin 15-expressing bulge cells. Deletion of Igf1r after the development of the skin appendages in K15-Igf1r(KO) mice showed no abnormalities in epidermal homoeostasis. Numbers of bulge cells were lower in K15-Igf1r(KO) mice than in controls, without consequences on wound healing, at least in young mice...
January 17, 2017: Experimental Dermatology
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