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https://www.readbyqxmd.com/read/28405550/assembling-a-hand-held-trichotillometer-and-determination-of-epilation-force-in-normal-individuals
#1
Kumaresan Muthuvel, Srinivas Chakravati, Sasidaharan Nair
AIM: To assemble a simple, inexpensive hand-held trichotillometer and to determine the epilation force (EF) required to pluck the anagen hair and telogen hair from four regions of the scalp in healthy volunteers. MATERIALS AND METHODS: A simple hand-held trichotillometer was assembled by modifying a laboratory spring balance, and the instrument was calibrated after attachments. EF was measured in 30 healthy individuals on four regions of the scalp. RESULTS: A total of 30 volunteers were included in the study, among them 15 were males and 15 were females...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28401988/a-rapid-nuclear-staining-test-using-cationic-dyes-contributes-to-efficient-str-analysis-of-telogen-hair-roots
#2
So-Yeon Lee, Eun-Ju Ha, Seung-Kyun Woo, So-Min Lee, Kyung-Hee Lim, Yong-Bin Eom
Telogen hairs presented in the crime scene are commonly encountered as trace evidence. However, short tandem repeat (STR) profiling of the hairs currently have low and limited use due to poor success rate. To increase the success rate of STR profiling of telogen hairs, we developed a rapid and cost-effective method to estimate the number of nuclei in the hair roots. Five cationic dyes, Methyl green (MG), Harris hematoxylin (HH), Methylene blue (MB), Toluidine blue (TB) and Safranin O (SO) were evaluated in this study...
April 12, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28396101/the-effectiveness-of-treatments-for-androgenetic-alopecia-a-systematic-review-and-meta-analysis
#3
REVIEW
Areej Adil, Marshall Godwin
BACKGROUND: Androgenetic alopecia, or male pattern hair loss, is a hair loss disorder mediated by dihydrotestosterone, the potent form of testosterone. Currently, minoxidil and finasteride are Food and Drug Administration (FDA)-approved, and HairMax LaserComb, which is FDA-cleared, are the only treatments recognized by the FDA as treatments of androgenetic alopecia. OBJECTIVE: This systematic review and meta-analysis assesses the efficacy of nonsurgical treatments of androgenetic alopecia in comparison to placebo for improving hair density, thickness, growth (defined by an increased anagen:telogen ratio), or subjective global assessments done by patients and investigators...
April 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28345588/macrophages-induce-akt-%C3%AE-catenin-dependent-lgr5-stem-cell-activation-and-hair-follicle-regeneration-through-tnf
#4
Xusheng Wang, Haiyan Chen, Ruiyun Tian, Yiling Zhang, Marina S Drutskaya, Chengmei Wang, Jianfeng Ge, Zhimeng Fan, Deqiang Kong, Xiaoxiao Wang, Ting Cai, Ying Zhou, Jingwen Wang, Jinmei Wang, Shan Wang, Zhihai Qin, Huanhuan Jia, Yue Wu, Jia Liu, Sergei A Nedospasov, Edward E Tredget, Mei Lin, Jianjun Liu, Yuyang Jiang, Yaojiong Wu
Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen-anagen transition (TAT) around the wound and de novo HF regeneration, mostly through TNF signalling. Both TNF knockout and overexpression attenuate HF neogenesis in wounds, suggesting dose-dependent induction of HF neogenesis by TNF, which is consistent with TNF-induced AKT signalling in epidermal stem cells in vitro...
March 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28329519/tnf-inhibitor-induced-alopecia-an-unusual-form-of-psoriasiform-alopecia-that-breaks-the-renb%C3%A3-k-mold
#5
Lauren N Craddock, David M Cooley, Justin O Endo, B Jack Longley, Freddy Caldera
TNF-α-inhibitors are known to induce skin adverseeffects including psoriasis and alopecia areata. Here, wedescribe a unique pattern of hair loss that has psoriaticand alopecia areata-like features. Diagnosis requiresclinical-pathologic correlation and is supportedby increased catagen/telogen hairs, psoriasiformepidermal hyperplasia, perifollicular lymphocyticinfiltrate, and the presence of eosinophils and plasmacells. Although there are no treatment consensusguidelines, management options include stoppingtherapy, switching to a different TNF-α inhibitor orustekinumab (in severe cases), or continuing TNF-αinhibitor therapy with addition of topical, intralesional,or systemic immunosuppressants...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28280377/promotion-of-anagen-increased-hair-density-and-reduction-of-hair-fall-in-a-clinical-setting-following-identification-of-fgf5-inhibiting-compounds-via-a-novel-2-stage-process
#6
Dominic Burg, Masakuni Yamamoto, Masato Namekata, Joseph Haklani, Koichiro Koike, Maria Halasz
BACKGROUND: There are very few effective, scientifically validated treatments with known mechanisms of action for treatment of hair loss in both men and women. Fibroblast growth factor 5 (FGF5) is an important factor in the irreversible transition from anagen to catagen, and inhibition of FGF5 prolongs anagen phase and reduces hair loss. OBJECTIVE: We aimed to screen botanically derived molecules for FGF5 inhibitory activity in vitro and assess efficacy in a clinical setting...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28259688/hair-growth-cycle-is-arrested-in-scd1-deficiency-by-impaired-wnt3a-palmitoleoylation-and-retrieved-by-artificial-lipid-barrier
#7
Wilhelm Stoffel, Inga Schmidt-Soltau, Britta Jenke, Erika Binczek, Ina Hammels
Stearoyl-CoA desaturase 1 (SCD1) is the dominant member of the SCD-isozyme family, regarded as a major regulator of lipid and energy metabolism in liver and adipose tissue. SCD1-deficiency impairs the desaturation of de novo-synthesized palmitoyl- and stearoyl-CoA to palmitoleoyl- and oleoyl- CoA. Scd1-/- mice develop metabolic waste syndrome and skin lesions: epidermal barrier disruption, alopecia and degeneration of sebaceous glands. The unifying molecular link between the two divergent traits remains incompletely understood...
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28229231/hair-follicle-changes-following-intense-pulsed-light-axillary-hair-reduction-histometrical-histological-and-immunohistochemical-evaluation
#8
Moetaz El-Domyati, Wael Hosam, Noha H Moftah, Hamza Abdel Raouf, Selwet M Saad
Intense pulsed light (IPL) has been used for years in hair reduction; however, no previous studies discussed quantitative histological and immunohistochemical changes of hair follicles after IPL. Accordingly, this study aims to objectively quantify histological and immunohistochemical changes of hair follicles after IPL hair reduction. Right axillae of 21 volunteers were subjected to 6 IPL sessions using Quanta system IPL and evaluated at 1 week and 1 month after last session (i.e., 3 and 4 months from the start of treatment, respectively) in comparison to baseline and left control axillae...
April 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28225954/frequency-severity-and-related-factors-of-androgenetic-alopecia-in-dermatology-outpatient-clinic-hospital-based-cross-sectional-study-in-turkey
#9
Kubra Esen Salman, Ilknur Kivanc Altunay, Nihal Asli Kucukunal, Asli Aksu Cerman
BACKGROUND: Androgenetic alopecia (AGA) is a patterned hair loss occurring due to systemic androgen and genetic factors. It is the most common cause of hair loss in both genders. In recent years, many studies investigating the relation between systemic diseases and androgenetic alopecia presented controversial results. OBJECTIVES: In this study we aimed to investigate the frequency of androgenetic alopecia, the presence of accompanying systemic diseases, the relation between body mass index and androgenetic alopecia severity and the association of hyperandrogenemia signs with androgenetic alopecia in patients who referred to our outpatient clinic...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28211089/icariin-promotes-mouse-hair-follicle-growth-by-increasing-insulin-like-growth-factor-1-expression-in-dermal-papillary-cells
#10
Y-S Su, Z-X Fan, S-E Xiao, B-J Lin, Y Miao, Z-Q Hu, H Liu
BACKGROUND: Icariin is a major flavonoid isolated from Epimedium spp. leaves (Epimedium Herba), and has multiple pharmacological functions, including anti-angiogenesis, anti-oxidant, anti-inflammatory and immunoprotective effects. AIM: To investigate whether icariin can stimulate growth of hair follicles in mice and the underlying mechanism. METHODS: In vitro, the effect of icariin on hair growth was assessed by using a vibrissae hair follicle (VHF) organ-culture model...
February 16, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28185006/hair-follicle-stem-cell-proliferation-akt-and-wnt-signaling-activation-in-tpa-induced-hair-regeneration
#11
Weiming Qiu, Mingxing Lei, Ling Zhou, Xiufeng Bai, Xiangdong Lai, Yu Yu, Tian Yang, Xiaohua Lian
Regeneration of hair follicles relies on activation of hair follicle stem cells during telogen to anagen transition process in hair cycle. This process is rigorously controlled by intrinsic and environmental factors. 12-o-tetradecanoylphorbol-13-acetate (TPA), a tumor promoter, accelerates reentry of hair follicles into anagen phase. However, it is unclear that how TPA promotes the hair regeneration. In the present study, we topically applied TPA onto the dorsal skin of 2-month-old C57BL/6 female mice to examine the activity of hair follicle stem cells and alteration of signaling pathways during hair regeneration...
February 9, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28143780/msi2-maintains-quiescent-state-of-hair-follicle-stem-cells-by-directly-repressing-the-hh-signaling-pathway
#12
Xianghui Ma, Yuhua Tian, Yongli Song, Jianyun Shi, Jiuzhi Xu, Kai Xiong, Jia Li, Wenjie Xu, Yiqiang Zhao, Jianwei Shuai, Lei Chen, Maksim V Plikus, Christopher J Lengner, Fazheng Ren, Lixiang Xue, Zhengquan Yu
Hair follicles (HFs) undergo precisely regulated cycles of active regeneration (anagen), involution (catagen), and relative quiescence (telogen). Hair follicle stem cells (HFSCs) play important roles in regenerative cycling. Elucidating mechanisms that govern HFSC behavior can help uncover the underlying principles of hair development, hair growth disorders, and skin cancers. RNA-binding proteins of the Musashi (Msi) have been implicated in the biology of different stem cell types, yet they have not been studied in HFSCs...
May 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28117106/stress-induced-premature-senescence-of-dermal-papilla-cells-compromises-hair-follicle-epithelial-mesenchymal-interaction
#13
Wen-Yen Huang, Yi-Ching Huang, Kai-Shin Huang, Chih-Chieh Chan, Hsien-Yi Chiu, Ren-Yeu Tsai, Jung-Yi Chan, Sung-Jan Lin
BACKGROUND: Hair follicle is miniorgan constituted by keratinocytes and its distinctive mesenchyme of dermal papilla. Its aging is characterized by organ atrophy and impaired stem cell activation and differentiation. The contribution of dermal papilla to hair follicle aging change is not well understood. OBJECTIVE: This work was aimed at exploring the possible role of premature dermal papilla senescence in the pathogenesis of hair follicle aging. METHODS: Dermal papilla cells were challenged with H2O2 to induce premature senescence and the proliferation, apoptosis, gene expression and protein secretion were characterized...
May 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27997570/the-study-on-biological-function-of-keratin-26-a-novel-member-of-liaoning-cashmere-goat-keratin-gene-family
#14
Mei Jin, Jing Wang, Ming-Xing Chu, Jun Piao, Jing-Ai Piao, Feng-Qin Zhao
In our research, we explored the relationship between Keratin 26 and the regulation of fine hair, BMP signaling pathway, MT, FGF5, and IGF-I. The result of hybridization in situ revealed that Keratin 26 was specially expressed in cortex of skin hair follicles; the result of immunohistochemistry indicated that Keratin 26 was expressed in internal root sheath, external root sheath. Then, Real-time quantitative PCR results showed that relative expressive quantity of Keratin 26 was 1.08 or 3.3 × greater in secondary follicle than primary follicle during anagen or catagen; the difference during anagen was not remarkable (p>0...
2016: PloS One
https://www.readbyqxmd.com/read/27881935/hair-diseases-a-big-problem-on-a-small-surface
#15
REVIEW
Ligia A Brzezińska-Wcisło, Dominika Wcisło-Dziadecka
Civilizational progress initially contributes to the problem of hair loss and then to alopecia as regards both frequency and therapeutic dilemmas. The work presents trichological problems which occur more rarely, i.e. drug-induced, anagen and telogen alopecia, congenital and acquired structural hair disorders, psychic disturbances concerning the hair as well as the hair during menopause. Then, the article briefly describes contagious (infectious) diseases as well as diseases with inflammatory etiology which are accompanied by exfoliation and (frequently) pruritus...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27864971/proximal-end-root-morphology-characteristics-in-antemortem-anagen-head-hairs
#16
Katherine A Roberts, Lino R Garcia, Peter R De Forest
The proximal end morphology of antemortem anagen head hair was compared with the characteristics documented to occur in postmortem hairs. Antemortem anagen and telogen head hairs (N = 967) were recovered following exposure to seven environments. Root morphology characteristics consistent with those reported in postmortem hairs were observed in 66 (14%) hairs exposed to a water, normal saline, outdoor soil, or indoor shower environment. Thirty-three anagen hairs (7%) exhibited a root band at the proximal end...
November 16, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27843921/telogen-effluvium-is-there-a-need-for-a-new-classification
#17
EDITORIAL
Ralph M Trüeb
No abstract text is available yet for this article.
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27843920/proposing-a-simpler-classification-of-telogen-effluvium
#18
REVIEW
Alfredo Rebora
Telogen effluvium (TE) is a pathogenically heterogeneous condition which so far has been classified into acute and chronic forms - or, according to Headington, into 5 different pathogenetic forms. Regrettably, Headington's classification is difficult to apply in the office, and most papers dealing with TE ignore it. The present review intends to propose a novel classification of TE and to introduce, tentatively, a new variety of TE. Three pathogenetic types of TE can be identified, whose common clinical element is the profuse shedding of hairs: (1) premature teloptosis, (2) collective teloptosis, and (3) premature entry into the telogen phase...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27772548/jak-stat-signaling-jump-starts-the-hair-cycle
#19
Etienne Wang, Sivan Harel, Angela M Christiano
Legrand et al show that JAK/STAT5 signaling in the dermal papilla is required for anagen onset in the murine hair cycle. Interestingly, others have shown that JAK-inhibition is able to induce telogen-to-anagen transition in wild-type mice. This apparent contradiction highlights the complexity of interactions within the hair follicle, and encourages further discussion on the role of JAK-STAT signaling in the various stem cell niches of the hair follicle.
November 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27754706/transcriptome-wide-comparative-analysis-of-microrna-profiles-in-the-telogen-skins-of-liaoning-cashmere-goats-capra-hircus-and-fine-wool-sheep-ovis-aries-by-solexa-deep-sequencing
#20
COMPARATIVE STUDY
Jianping Li, HaiE Qu, Huaizhi Jiang, Zhihui Zhao, Qiaoling Zhang
Compare the microRNA (miRNA) trancriptomes of goat and sheep skin using Solexa sequencing to understand the development of skin and hair follicles (HFs). miRNA expression patterns vary in the two small RNA libraries from goat (G library) and sheep (S library) telogen skin samples. Analysis of the size distribution of 25.32 million clean reads revealed that most are 21-23 nucleotides. A total of 1910 known miRNAs and 2261 novel mature miRNAs were identified in this study. Among them, 107 novel miRNAs and 1246 known miRNAs were differentially expressed in the two libraries; 10 of the known miRNAs were identified using stem-loop quantitative real-time PCR...
November 2016: DNA and Cell Biology
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