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https://www.readbyqxmd.com/read/28627318/effects-of-gamma-rays-on-the-regeneration-of-murine-hair-follicles-in-the-natural-hair-cycle
#1
Kimihiko Sugaya
PURPOSE: This review evaluates the effects of γ-rays on the regeneration of murine hair follicles in the natural hair cycle. A series of studies were performed to investigate this issue, in which the whole bodies of C57BL/10JHir mice in the 1(st) telogen phase of the hair cycle were irradiated with γ-rays. RESULTS: The dermis of the irradiated skin showed a decrease in hair follicle density and induction of curved hair follicles along with the presence of white hairs and hypopigmented hair bulbs in the 2(nd) and 3(rd) anagen phases...
June 19, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28612487/anagen-effluvium-in-association-with-extracorporeal-membrane-oxygenation
#2
Lisa Cotter, Kyle Cheng, Anna Yasmine Kirkorian
Anagen effluvium (AE) is a type of alopecia with hair loss during the growth phase of a hair follicle and is most often associated with cytotoxic chemotherapy. This report describes a case of AE in a critically ill 2-year-old boy who developed cardiorespiratory failure requiring extracorporeal membranous oxygenation. We postulate that the combination of hypotension and hypoxia with subsequent reperfusion triggered an apoptotic cascade in the hair matrix, resulting in AE.
June 13, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28544234/clinical-microscopic-and-ultrastructural-findings-in-a-case-of-short-anagen-syndrome
#3
Jose M Martin, Encarnacion Montesinos, Sara Sanchez, Catalina Torres, Dolores Ramon
Short anagen syndrome is an uncommon and recently described disease characterized by many telogen hairs and short maximum hair length. We report here the case of a 3-year-old girl whose short, sparse, fine hair since birth was consistent with short anagen syndrome. X-ray microanalysis demonstrated normal composition of the main bioelements of her hairs.
May 23, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28536317/-hair-follicle-stem-cells
#4
Shun Sawatsubashi
The hair follicle is a complex miniorgan of the skin and undergoes cycles of growth(anagen), apoptosis-mediated regression(catagen)and rest(telogen). Regeneration of the new hair shaft dependent on the activation of hair follicle stem cells(HFSCs), harboured in the bulge region. Using a hair follicle model, some molecular players that control the balance between HFSC maintenance and ageing-associated HFSC dysfunction have been identified. Here, we reviewed and discussed the recent findings of molecular characterization of HFSCs biology and pathology...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28530053/-alopecia-areata
#5
REVIEW
Yaron Zafrir, Sharon Baum, Shoshi Greenberger, Anna Lyakhovitsky, Aviv Barzilai
Alopecia areata (AA) is an organ specific autoimmune disease. Similar to other autoimmune diseases, its pathogenesis is believed to be an interaction of genetic, environmental and immune factors. Studies have shown that autoreactive lymphocytes affect anagen hair follicles leading to subsequent shedding of hairs and alopecia. Clinically, the disease is characterized by sudden nonscarring hair loss that usually involves the scalp, but may also affect the face and other body areas, and indeed the entire body hair...
October 2016: Harefuah
https://www.readbyqxmd.com/read/28528395/enhancing-hair-growth-in-male-androgenetic-alopecia-by-a-combination-of-fractional-co2-laser-therapy-and-hair-growth-factors
#6
Yue Huang, Fenglin Zhuo, Linfeng Li
Laser therapy and growth factors have been used as alternative treatments for male androgenetic alopecia (MAA). The aim of this study is to determine the efficacy and safety of hair growth factors alone or combined with ablative carbon dioxide (CO2) fractional laser therapy in MAA. Twenty-eight men were enrolled in this randomized half-split study based on a left-head to right-head pattern. Fractional CO2 laser treatment was unilaterally performed; hair growth factors were bilaterally applied. Six sessions with 2-week intervals were performed...
May 21, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28508243/low-level-laser-treatment-stimulates-hair-growth-via-upregulating-wnt10b-and-%C3%AE-catenin-expression-in-c3h-hej-mice
#7
Tiran Zhang, Liqiang Liu, Jincai Fan, Jia Tian, Cheng Gan, Zengjie Yang, Hu Jiao, Bing Han, Zheng Liu
This study was conducted in order to evaluate the role of low-level laser treatment (LLLT) in hair growth in C3H/HeJ mice. Healthy C57BL/6 mice were randomly divided into two groups: with and without low-level laser treatment. The skin color of each mouse was observed each day. Skin samples were collected for H&E, immunofluorescence, PCR, and western blot analysis, to observe the morphology of hair follicles and detect the expression levels of Wnt10b and β-catenin. Observation of skin color demonstrated that black pigmentation started significantly earlier in the laser group than in the control group...
May 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28500774/the-transcriptional-landscape-of-seasonal-coat-colour-moult-in-the-snowshoe-hare
#8
Mafalda S Ferreira, Paulo C Alves, Colin M Callahan, João P Marques, L Scott Mills, Jeffrey M Good, José Melo-Ferreira
Seasonal coat colour change is an important adaptation to seasonally changing environments but the evolution of this and other circannual traits remains poorly understood. In this study we use gene expression to understand seasonal coat colour moulting in wild snowshoe hares (Lepus americanus). We used hair colour to follow the progression of the moult, simultaneously sampling skin from three moulting stages in hares collected during the peak of the spring moult from white winter to brown summer pelage. Using RNA-sequencing, we tested if patterns of expression were consistent with predictions based on the established phases of the hair growth cycle...
May 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28497393/effect-of-miscanthus-sinensis-var-purpurascens-flower-extract-on-proliferation-and-molecular-regulation-in-human-dermal-papilla-cells-and-stressed-c57bl-6-mice
#9
GiHee Jeong, William A Boisvert, Mei-Zhu Xi, Yi-Lin Zhang, Young-Bin Choi, Sunghun Cho, Sanghyun Lee, Changsun Choi, Bog-Hieu Lee
OBJECTIVES: To investigate the hair growth-promoting effect of Miscanthus sinensis var. purpurascens (MSP) flower extracton on in vitro and in vivo models. METHODS: MSP flower extract was extracted in 99.9% methanol and applied to examine the proliferation of human dermal papilla cells (hDPCs) in vitro at the dose of 3.92-62.50 μg/mL and hair growth of C57BL/6 mice in vivo at the dose of 1000 μg/mL. The expression of transforming growth factor β1 (TGF-β1), hepatocyte growth factor (HGF), β-catenin, substance P was measured by relative quantitative realtime polymerase chain reaction...
May 11, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28475144/undariopsis-peterseniana-promotes-hair-growth-by-the-activation-of-wnt-%C3%AE-catenin-and-erk-pathways
#10
Jung-Il Kang, Min-Kyoung Kim, Ji-Hyeok Lee, You-Jin Jeon, Eun-Kyoung Hwang, Young-Sang Koh, Jin-Won Hyun, Soon-Young Kwon, Eun-Sook Yoo, Hee-Kyoung Kang
In this study, we investigated the effect and mechanism of Undariopsis peterseniana, an edible brown alga, on hair growth. The treatment of vibrissa follicles with U. peterseniana extract ex vivo for 21 days significantly increased the hair-fiber lengths. The U. peterseniana extract also significantly accelerated anagen initiation in vivo. Moreover, we found that U. peterseniana extract was able to open the KATP channel, which may contribute to increased hair growth. The U. peterseniana extract decreased 5α-reductase activity and markedly increased the proliferation of dermal papilla cells, a central regulator of the hair cycle...
May 5, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28463974/the-histological-characteristics-age-related-thickness-change-of-skin-and-expression-of-the-hsps-in-the-skin-during-hair-cycle-in-yak-bos-grunniens
#11
Xue Yang, Yan Cui, Jing Yue, Honghong He, Chuan Yu, Penggang Liu, Jun Liu, Xiandong Ren, Yun Meng
OBJECTIVE: This experiment was conducted to study the histological characteristics, age-related thickness changes, and expression of HSPs in the skin of yak. METHODS: A total of 20 yaks (10 males and 10 females) were used. Different regions of the normal skin of three different ages (newborn, half-year-old and adult) of yaks were harvested for histological study and thickness measurement. Biopsy samples were taken from the scapula regions of the skin from the same five approximately 1-year-old yaks during the hair cycle (telogen, anagen and catagen)...
2017: PloS One
https://www.readbyqxmd.com/read/28442878/loose-anchoring-of-anagen-hairs-and-pili-torti-due-to-erlotinib
#12
Rodrigo Pirmez, Juan Piñeiro-Maceira, Carmen Gloria Gonzalez, Mariya Miteva
Erlotinib is a selective epidermal growth factor receptor inhibitor utilized in the treatment of solid tumors. Cutaneous side effects, including changes in hair texture and alopecia, have been described. In this case report, we describe two patients with a new finding of loose anagen hairs and pili torti leading to nonscarring marginal and diffuse alopecia and discuss potential mechanisms underlying erlotinib-induced hair changes.
October 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/28442873/anagen-effluvium-following-acute-colchicine-poisoning
#13
Andrea Combalia, Carola Baliu-Piqué, Adriana Fortea, Juan Ferrando
We present a case of a 17-year-old girl admitted to the Psychiatric Department recovering from a suicide attempt with colchicine. One week after poisoning, a sudden onset of hair loss was observed. Positive hair pull test and trichoscopy demonstrated the presence of anagen hairs with pigmented long roots covered by the root sheaths. Colchicine poisoning is an uncommon, but potentially life-threatening toxicologic emergency. An overdose of colchicine inhibits cell division, and thus the most affected organs are those which have a high rate of cell turnover...
October 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/28436024/hair-diameter-evaluation-in-different-regions-of-the-safe-donor-area-in-asian-populations
#14
Jae H Park, Jae M Park, Na R Kim, Kotchamol Manonukul
BACKGROUND: There is little information about how hair diameter differences within the safe donor area. Thicker or thinner hair may be needed depending on the recipient area, hairline design, and surgical purpose. METHODS: Thirty-eight non-alopecic subjects (19 males and 19 females) were evaluated. The safe donor area was defined as the area contained within 28 cm from the horizontal plane of the upper border of the hair rim to the vertical line of the bilateral external acoustic meatus...
April 24, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28423200/cd80cd86-deficiency-disrupts-regulatory-cd4-foxp3-t-cell-homeostasis-and-induces-autoimmune-like-alopecia
#15
Ji-Hyun Bae, Woo-Sung Hwang, Yoo-Jin Jang, Yoon-Hoo Lee, Da-Eun Jang, Jung-Sik Kim, Su-Cheong Yeom
Alopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6.CD80CD86-deficient (B6.CD80CD86(-/-) ) mice. Incidence and severity of alopecia were analyzed in 58 B6.CD80CD86(-/-) mice by using histological examination, flow cytometry, multiplex enzyme-linked immunosorbent assay, quantitative RT-PCR, and CD25 inhibition test. Both male and female B6...
April 19, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28418107/a-new-path-in-defining-light-parameters-for-hair-growth-discovery-and-modulation-of-photoreceptors-in-human-hair-follicle
#16
Serena Buscone, Andrei N Mardaryev, Bianca Raafs, Jan W Bikker, Carsten Sticht, Norbert Gretz, Nilofer Farjo, Natallia E Uzunbajakava, Natalia V Botchkareva
BACKGROUND AND OBJECTIVE: Though devices for hair growth based on low levels of light have shown encouraging results, further improvements of their efficacy is impeded by a lack of knowledge on the exact molecular targets that mediate physiological response in skin and hair follicle. The aim of this study was to investigate the expression of selected light-sensitive receptors in the human hair follicle and to study the impact of UV-free blue light on hair growth ex vivo. MATERIAL AND METHODS: The expression of Opsin receptors in human skin and hair follicles has been characterized using RT-qPCR and immunofluorescence approaches...
April 18, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28413121/characterisation-of-cell-cycle-arrest-and-terminal-differentiation-in-a-maximally-proliferative-human-epithelial-tissue-lessons-from-the-human-hair-follicle-matrix
#17
Talveen S Purba, Lars Brunken, Michael Peake, Asim Shahmalak, Asuncion Chaves, Enrique Poblet, Ralf Paus
Human hair follicle (HF) growth and hair shaft formation require terminal differentiation-associated cell cycle arrest of highly proliferative matrix keratinocytes. However, the regulation of this complex event remains unknown. CIP/KIP family member proteins (p21(CIP1), p27(KIP1) and p57(KIP2)) regulate cell cycle progression/arrest, endoreplication, differentiation and apoptosis. Since they have not yet been adequately characterized in the human HF, we asked whether and where CIP/KIP proteins localise in the human hair matrix and pre-cortex in relation to cell cycle activity and HF-specific epithelial cell differentiation that is marked by keratin 85 (K85) protein expression...
April 2, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28405550/assembling-a-hand-held-trichotillometer-and-determination-of-epilation-force-in-normal-individuals
#18
Kumaresan Muthuvel, Srinivas Chakravati, Sasidaharan Nair
AIM: To assemble a simple, inexpensive hand-held trichotillometer and to determine the epilation force (EF) required to pluck the anagen hair and telogen hair from four regions of the scalp in healthy volunteers. MATERIALS AND METHODS: A simple hand-held trichotillometer was assembled by modifying a laboratory spring balance, and the instrument was calibrated after attachments. EF was measured in 30 healthy individuals on four regions of the scalp. RESULTS: A total of 30 volunteers were included in the study, among them 15 were males and 15 were females...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28396101/the-effectiveness-of-treatments-for-androgenetic-alopecia-a-systematic-review-and-meta-analysis
#19
REVIEW
Areej Adil, Marshall Godwin
BACKGROUND: Androgenetic alopecia, or male pattern hair loss, is a hair loss disorder mediated by dihydrotestosterone, the potent form of testosterone. Currently, minoxidil and finasteride are Food and Drug Administration (FDA)-approved, and HairMax LaserComb, which is FDA-cleared, are the only treatments recognized by the FDA as treatments of androgenetic alopecia. OBJECTIVE: This systematic review and meta-analysis assesses the efficacy of nonsurgical treatments of androgenetic alopecia in comparison to placebo for improving hair density, thickness, growth (defined by an increased anagen:telogen ratio), or subjective global assessments done by patients and investigators...
April 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28371260/phenotypic-spectrum-of-costello-syndrome-individuals-harboring-the-rare-hras-mutation-p-gly13asp
#20
Débora Bertola, Michelle Buscarilli, Deborah L Stabley, Laura Baker, Daniel Doyle, Dennis W Bartholomew, Katia Sol-Church, Karen W Gripp
Costello syndrome is part of the RASopathies, a group of neurocardiofaciocutaneous syndromes caused by deregulation of the RAS mitogen-activated protein kinase pathway. Heterozygous mutations in HRAS are responsible for Costello syndrome, with more than 80% of the patients harboring the specific p.Gly12Ser variant. These individuals show a homogeneous phenotype. The clinical characteristics of the Costello syndrome individuals harboring rarer HRAS mutations are less understood, due to the small number of reported cases...
May 2017: American Journal of Medical Genetics. Part A
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