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https://www.readbyqxmd.com/read/29770335/the-significance-of-scalp-involvement-in-pemphigus-a-literature-review
#1
REVIEW
Marta Sar-Pomian, Lidia Rudnicka, Malgorzata Olszewska
Scalp is a unique location for pemphigus because of the abundance of desmogleins localized in hair follicles. Scalp involvement is observed in up to 60% of patients in the course of pemphigus. The lesions may occasionally lead to alopecia. Unforced removal of anagen hairs in a pull test is a sign of high disease activity. Direct immunofluorescence of plucked hair bulbs is considered a reliable diagnostic method in patients with pemphigus. Follicular acantholysis is a characteristic histopathological feature of pemphigus lesions localized on the scalp...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29766701/new-multi-targeting-strategy-in-hair-growth-promotion-in-vitro-and-in-vivo-studies
#2
Barbara Marzani, Daniela Pinto, Elisabetta Sorbellini, Fabio Rinaldi
BACKGROUND: Considering the importance of hair in our modern society and the impact of hair loss, the efforts of researchers are addressed to better understand the mechanisms behind the hair cycle regulation and dysregulation. Because hair loss is multifactorial, differenced and new approaches are required. In particular we addressed our attention to two recently identified targets in hair cycling and growth control: olfactory receptor and autophagy. The aim of the study was to evaluate: the possible pro-autophagic effect of N1-methylspermidine (a spermidine analogue) in vitro and, in a double blind clinical trial, the safety and efficacy of topical daily application of a lotion containing N1-methylspermidine and Sandalore®...
June 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29763605/inos-inhibits-hair-regeneration-in-obese-diabetic-ob-ob-mice
#3
Mari Sasaki, Shohei Shinozaki, Hironobu Morinaga, Masao Kaneki, Emi Nishimura, Kentaro Shimokado
Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes alopecia still remains unclear. We focused on the inflammatory response that is caused by diabetes or obesity, given that inflammation is a risk factor for hair loss. Inducible nitric oxide synthase (iNOS) is known to be upregulated under conditions of acute or chronic inflammation. To clarify the potential role of iNOS in diabetes-related alopecia, we generated obese diabetic iNOS-deficient (ob/ob; iNOS-KO mice)...
May 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29737035/systemic-lupus-erythematosus-in-a-patient-with-noonan-syndrome-like-disorder-with-loose-anagen-hair-1-more-than-a-chance-association
#4
Tomoko Uehara, Naoki Hosogaya, Nobutake Matsuo, Kenjiro Kosaki
Systemic lupus erythematosus (SLE) has been reported among patients with RASopathy. Five patients have been reported: three with SHOC2 variants, one with a PTPN11 variant, and one with a KRAS variant. SHOC2 variant might represent a relatively common predisposing factor for SLE among the RASopathy genes. However, the clinical details were only reported for two patients, while information on the remaining patient appeared only in a tabular format with minimal clinical description. Here, we report a patient with a SHOC2 variant and SLE...
May 7, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29705113/loose-anagen-hair-syndrome
#5
Allison Zarbo, Tor Shwayder
No abstract text is available yet for this article.
April 25, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29704126/dermal-white-adipose-tissue-undergoes-major-morphological-changes-during-the-spontaneous-and-induced-murine-hair-follicle-cycling-a-reappraisal
#6
April R Foster, Carina Nicu, Marlon R Schneider, Eleanor Hinde, Ralf Paus
In murine skin, dermal white adipose tissue (DWAT) undergoes major changes in thickness in synchrony with the hair cycle (HC); however, the underlying mechanisms remain unclear. We sought to elucidate whether increased DWAT thickness during anagen is mediated by adipocyte hypertrophy or adipogenesis, and whether lipolysis or apoptosis can explain the decreased DWAT thickness during catagen. In addition, we compared HC-associated DWAT changes between spontaneous and depilation-induced hair follicle (HF) cycling to distinguish between spontaneous and HF trauma-induced events...
April 27, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29679494/risk-of-sun-induced-skin-cancers-in-patients-with-alopecia-areata-alopecia-totalis-and-alopecia-universalis
#7
Rosalynn R Z Conic, Rose Miller, Melissa Piliang, Wilma Bergfeld, Natasha Atanaskova Mesinkovska
Alopecia areata (AA) is an autoimmune non-scarring hair loss characterized by round patches on the scalp and body. It can progress to alopecia totalis (AT) where there is total loss of scalp hair and alopecia universalis (AU) in where hair loss encompasses the entire body. The pathophysiologic mechanism is unclear, but is thought to be due to peribulbar T-cell inflammation which results in premature induction of anagen follicles to catagen and telogen, without causing destruction of the hair follicle. This article is protected by copyright...
April 21, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29678305/the-effect-of-cilostazol-a-phosphodiesterase-3-pde3-inhibitor-on-human-hair-growth-with-the-dual-promoting-mechanisms
#8
Hye-In Choi, Dong Young Kim, Soon-Jin Choi, Chang-Yup Shin, Sungjoo Tommy Hwang, Kyu Han Kim, Ohsang Kwon
BACKGROUND: Cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, increases the intracellular level of cyclic adenosine monophosphate to cause vasodilation. Topical application of cilostazol is reported to improve local blood flow and enhance wound healing; however, its effect on human hair follicles is unknown. OBJECTIVE: The purpose of this study was to determine the effect of cilostazol on hair growth. METHODS: We investigated the expression of PDE3 in human dermal papilla cells (DPCs), outer root sheath cells (ORSCs), and hair follicles...
April 11, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29672929/functional-anatomy-of-the-hair-follicle-the-secondary-hair-germ
#9
REVIEW
Andrey A Panteleyev
The secondary hair germ (SHG) - a transitory structure in the lower portion of the mouse telogen hair follicle (HF) - is directly involved in anagen induction and eventual HF regrowth. Some crucial aspects of SHG functioning and ontogenetic relations with other HF parts, however, remain undefined. According to recent evidence (in contrast to previous bulge-centric views), the SHG is the primary target of anagen-inducing signaling and a source of both the outer root sheath (ORS) and ascending HF layers during the initial (morphogenetic) anagen sub-phase...
April 19, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29661011/protein-extraction-from-human-anagen-head-hairs-1-millimeter-or-less-in-total-length
#10
Traci L Carlson, Mehdi Moini, Brian A Eckenrode, Brent M Allred, Joseph Donfack
A simple method for extracting protein from human anagen (i.e., actively growing hair stage) head hairs was developed in this study for cases of limited sample availability and/or studies of specific micro-features within a hair. The distinct feature segments of the hair from one donor were divided lengthwise (i.e., each of ∼200-400 μm) and then pooled for three individual hairs to form a total of eight composite hair samples (i.e., each of ∼1 mm or less in total length). The proteins were extracted, digested using trypsin, and characterized via nano-flow liquid chromatography tandem-mass spectrometry (nLC-MS/MS)...
April 2018: BioTechniques
https://www.readbyqxmd.com/read/29627240/short-communication-temporal-changes-in-the-skin-morphology-of-dairy-cows-during-the-periparturient-period
#11
Banri Suzuki, Toshie Sugiyama, Chikako Yoshida, Toshihiko Nakao
Management of dairy cow productivity requires monitoring of their nutritional status by visual observation. It has been suggested that changes in hair coat appearance are among the indicators of nutritional state in dairy cows. Temporal changes in the skin morphology in cows, however, have not been reported. In this study, we examined the changes in the skin of dairy cows that occur during the peripartum period. Seven pluriparous cows were used. Skin samples were collected at 28 d before the due date and 28 d and 56 d after calving for morphological examination...
April 4, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29615452/glutamate-transporter-slc1a3-mediates-inter-niche-stem-cell-activation-during-skin-growth
#12
Bettina Reichenbach, Johanna Classon, Tomomi Aida, Kohichi Tanaka, Maria Genander, Christian Göritz
Tissues contain distinct stem cell niches, but whether cell turnover is coordinated between niches during growth is unknown. Here, we report that in mouse skin, hair growth is accompanied by sebaceous gland and interfollicular epidermis expansion. During hair growth, cells in the bulge and outer root sheath temporarily upregulate the glutamate transporter SLC1A3, and the number of SLC1A3+ basal cells in interfollicular epidermis and sebaceous gland increases. Fate mapping of SLC1A3+ cells in mice revealed transient expression in proliferating stem/progenitor cells in all three niches...
April 3, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29590104/autophagy-is-essential-for-maintaining-the-growth-of-a-human-mini-organ-evidence-from-scalp-hair-follicle-organ-culture
#13
Chiara Parodi, Jonathan A Hardman, Giulia Allavena, Roberto Marotta, Tiziano Catelani, Marta Bertolini, Ralf Paus, Benedetto Grimaldi
Autophagy plays a crucial role in health and disease, regulating central cellular processes such as adaptive stress responses, differentiation, tissue development, and homeostasis. However, the role of autophagy in human physiology is poorly understood, highlighting a need for a model human organ system to assess the efficacy and safety of strategies to therapeutically modulate autophagy. As a complete, cyclically remodelled (mini-)organ, the organ culture of human scalp hair follicles (HFs), which, after massive growth (anagen), spontaneously enter into an apoptosis-driven organ involution (catagen) process, may provide such a model...
March 2018: PLoS Biology
https://www.readbyqxmd.com/read/29587631/integrative-analysis-reveals-ncrna-mediated-molecular-regulatory-network-driving-secondary-hair-follicle-regression-in-cashmere-goats
#14
Guangxian Zhou, Danju Kang, Sen Ma, Xingtao Wang, Ye Gao, Yuxin Yang, Xiaolong Wang, Yulin Chen
BACKGROUND: Cashmere is a keratinized product derived from the secondary hair follicles (SHFs) of cashmere goat skins. The cashmere fiber stops growing following the transition from the actively proliferating anagen stage to the apoptosis-driven catagen stage. However, little is known regarding the molecular mechanisms responsible for the occurrence of apoptosis in SHFs, especially as pertains to the role of non-coding RNAs (ncRNAs) and their interactions with other molecules. Hair follicle (HF) degeneration is caused by localized apoptosis in the skin, while anti-apoptosis pathways may coexist in adjacent HFs...
March 27, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29582461/short-anagen-syndrome-case-series-and-literature-review
#15
Kate E Oberlin, Austin J Maddy, María Abril Martínez-Velasco, Norma Elizabeth Vázquez-Herrera, Lawrence A Schachner, Antonella Tosti
BACKGROUND/OBJECTIVES: Short anagen syndrome is a hair cycle disorder usually diagnosed in early childhood and characterized by short hair length due to short duration of the anagen phase. The objective was to review the presentation and demographic characteristics of short anagen syndrome and compare them with the most common differential diagnosis, loose anagen syndrome. METHODS: A retrospective review of eight children with short anagen syndrome was performed at the University of Miami Outpatient Dermatology Clinic...
March 26, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29572801/hair-shaft-growth-in-gelfoam-%C3%A2-histoculture-of-skin-and-isolated-hair-follicles
#16
Robert M Hoffman, Lingna Li, Wenluo Cao
Human scalp skin with abundant hair follicles in various stages of the hair growth cycle was histocultured for up to 40 days on Gelfoam® at the air/liquid interface. The anagen hair follicles within the histoculture scalp skin produced growing hair shafts. Hair follicles could continue their cycle in histoculture; for example, apparent spontaneous catagen induction was observed both histologically and by the actual regression of the hair follicle. In addition, vellus follicles were shown to be viable at day 40 after initiation of culture...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29566258/loose-anagen-hair-syndrome-treatment-with-systemic-minoxidil-characterised-by-marked-hair-colour-change
#17
William C Cranwell, Rodney Sinclair
No abstract text is available yet for this article.
March 22, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29564941/gene-expression-and-localization-of-lamtor3-in-the-skin-cells-of-liaoning-cashmere-goats
#18
Mei Jin, Ming Cao, Mingxing Chu, Jing'ai Piao, Xu Guo, Fengqin Zhao, Jun Piao
Liaoning cashmere goats are the most precious genetic resources in China. The function of LAMTOR3 [late endosomal/lysosomal adaptor, mitogen-activated protein kinase (MAPK), and mammalian target of rapamycin activator 3/MAPK scaffold protein 1] gene is expressed in the skin of Liaoning cashmere goats. In situ hybridization (ISH) found that LAMTOR3 is expressed in the inner root sheath (IRS) of hair follicles. During the anagen or catagen phase, the expression of LAMTOR3 is higher in secondary hair follicles than in primary hair follicles...
March 22, 2018: Animal Biotechnology
https://www.readbyqxmd.com/read/29549490/androgen-modulation-of-wnt-%C3%AE-catenin-signaling-in-androgenetic-alopecia
#19
REVIEW
A Premanand, B Reena Rajkumari
Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated expressions of 5α-dihydrotestosterone and androgen receptor are the causal factors for AGA. This review describes recent studies on the role of androgens and androgen receptor (AR) transactivation activity in modulating the Wnt/β-catenin signaling in the dermal papilla cells of the balding scalp in androgenetic alopecia...
March 16, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29527024/cutaneous-adverse-reactions-of-chemotherapy-in-cancer-patients-a-clinicoepidemiological-study
#20
Saumita Ghosh Biswal, Rajesh Datt Mehta
Background: The diagnosis of cutaneous adversities in the cancer patient is especially difficult, given the complexity of their illness and combination protocols used for the treatment. The present study was undertaken to know the spectrum of cutaneous adversities in patients undergoing chemotherapy and the drug(s) most commonly associated with it. Materials and Methods: A total of 1000 patients with malignancies under chemotherapy in the oncology ward and outpatient department were screened in this observational study from January 2013 to February 2015...
January 2018: Indian Journal of Dermatology
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