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Mark Schallenberger, Helena Lovick, Jalane Locke, Todd Meyer, Gregory Juda
During August and September of 2013, temperature data loggers were shipped to and from an AATB accredited and FDA registered allograft tissue processing facility in Belgrade, MT (Bacterin International, Inc.) to five warm climate cities (Dallas, TX, El Paso, TX, New Orleans, LA, Phoenix, AZ, and Tampa, FL). Shipping data acquired from 72 independent shipments were analyzed to generate an assessment of temperature exposure, shipment times, and shipping event durations experienced during routine distribution...
August 25, 2016: Cell and Tissue Banking
Xiang-Kai Zhu-Ge, Zi-Hao Pan, Fang Tang, Xiang Mao, Lin Hu, Shao-Hui Wang, Bin Xu, Cheng-Ping Lu, Hong-Jie Fan, Jian-Jun Dai
Autotransporters (ATs) are associated with pathogenesis of Avian Pathogenic Escherichia coli (APEC). The molecular characterization of APEC ATs can provide insights about their relevance to APEC pathogenesis. Here, we characterized a conventional autotransporter UpaB in APEC DE205B genome. The upaB existed in 41.9 % of 236 APEC isolates and was predominantly associated with ECOR B2 and D. Our studies showed that UpaB mediates the DE205B adhesion in DF-1 cells, and enhances autoaggregation and biofilm formation of fimbria-negative E...
December 2015: Applied Microbiology and Biotechnology
Sayo Matsuba, Satomi Niwa, Katsuhiko Muraki, Saki Kanatsuka, Yurika Nakazono, Noriyuki Hatano, Masanori Fujii, Peng Zhan, Takayoshi Suzuki, Susumu Ohya
The Ca(2+)-activated Cl(-) channel transmembrane proteins with unknown function 16 A (TMEM16A; also known as anoctamin 1 or discovered on gastrointestinal stromal tumor 1) plays an important role in facilitating the cell growth and metastasis of TMEM16A-expressing cancer cells. Histone deacetylase (HDAC) inhibitors (HDACi) are useful agents for cancer therapy, but it remains unclear whether ion channels are epigenetically regulated by them. Using real-time polymerase chain reaction, Western blot analysis, and whole-cell patch-clamp assays, we found a significant decrease in TMEM16A expression and its functional activity was induced by the vorinostat, a pan-HDACi in TMEM16A-expressing human cancer cell lines, the prostatic cancer cell line PC-3, and the breast cancer cell line YMB-1...
December 2014: Journal of Pharmacology and Experimental Therapeutics
Xiangkai Zhuge, Shaohui Wang, Hongjie Fan, Zihao Pan, Jianluan Ren, Li Yi, Qingmei Meng, Xuqiu Yang, Chengping Lu, Jianjun Dai
Autotransporter (AT) proteins constitute a large family of extracellular proteins that contribute to bacterial virulence. A novel AT adhesin gene, aatB, was identified in avian pathogenic Escherichia coli (APEC) DE205B via genomic analyses. The open reading frame of aatB was 1,017 bp, encoding a putative 36.3-kDa protein which contained structural motifs characteristic for AT proteins: a signal peptide, a passenger domain, and a translocator domain. The predicted three-dimensional structure of AatB consisted of two distinct domains, the C-terminal β-barrel translocator domain and an N-terminal passenger domain...
July 2013: Infection and Immunity
Christian Fölsch, Wolfram Mittelmeier, Uwe Bilderbeek, Nina Timmesfeld, Thomas von Garrel, Hans Peter Matter
BACKGROUND: The recommendations for storage temperature of allogeneic bone are varying between -20 °C and -70 °C and down to -80 °C. The necessary temperature of storage is not exactly defined by scientific data, and the effect of different storage temperatures onto the biomechanical and the biological behavior is discussed controversially. METHODS: The historical development of storage temperature of bone banks is described. A survey on literature concerning the biomechanical and biological properties of allograft bone depending on the procurement and storage temperature is given as well as on national and international regulations on storage conditions of bone banks (European Council, American Association of Tissue Banks (AATB), European Association of Tissue Banks (EATB))...
February 2012: Transfusion Medicine and Hemotherapy
Scott A Brubaker, P Robert Rigney
This report contains selected excerpts, presented as a summary, from a public workshop sponsored by the American Association of Tissue Banks (AATB) held to discuss West Nile Virus (WNV) and scientific considerations for tissue donors. The daylong workshop was held 9 July 2010 at the Ritz-Carlton Hotel at Tyson's Corner in McLean, Virginia, United States (U.S.). The workshop was designed to determine and discuss scientific information that is known, and what is not known, regarding WNV infection and transmission...
August 2012: Cell and Tissue Banking
Sharon Bryce, Fiona Taylor, Warwick Shaw
The objective was to document a Process Validation on the packaging of human tissue grafts using polystyrene boxes containing dry ice for short term storage. The aim was to give a high degree of assurance that the processed grafts would be maintained at -20 degrees C for a period of time to allow distribution to customers. This study was designed to comply with the Australian GMP-Human Blood and Tissues and AATB Standards for Tissue Banking (Ed 12) American Association of Tissue Banks Section E4.141-Storage Conditions for Commonly Transplanted Human Tissue...
August 2010: Cell and Tissue Banking
Scott A Brubaker, Chad J Ronholdt, Mark Moore
The 32nd annual meeting of the American Association of Tissue Banks (AATB) was highly praised by its participants and was the largest attended meeting in the AATB's history. Highlights included a record number of candidates taking the examination to become a certified tissue banking specialist (CTBS) and the acceptance of over thirty abstract submissions using, for the first time, an on-line submission, review, and grading system. This meeting's success was made possible by the exceptional participation of tissue bank professionals such as Medical Directors, managers, consultants, and technical experts; valuable input from international colleagues; and the involvement of federal regulators for cell and tissue banking...
April 14, 2010: Cell and Tissue Banking
Ruth M Warwick, Robert Parker, John N Kearney, Scott A Brubaker
The 17th Annual Meeting of the European Association of Tissue Banks (EATB) was held in Edinburgh in November 2008 together with the British Association for Tissue Banking (BATB) and received excellent evaluation by its participants. The meeting included, for the first time, a cardiovascular symposium co-organised by EATB and BATB together with the American Association of Tissue Banks (AATB). This was a first in terms of collaboration for the three associations. The many professionals involved in organising the meeting created an excellent clinical and scientific programme including regulatory issues and featured, also for the first time three interactive workshops about clinical donor cases, quality management and cardiovascular allografts...
April 14, 2010: Cell and Tissue Banking
Esteban Pujol, Bernard Bouvy, Miguel Omaña, Mar Fortuny, Luis Riera, Pedro Pujol
OBJECTIVE: To determine the applicability, complications, and long-term functional outcome of the Kishigami Atlantoaxial Tension Band (Kishigami AATB) for management of congenital and traumatic atlantoaxial (AA) instability in toy breed dogs. STUDY DESIGN; Case series. ANIMALS: Toy breed dogs (n=8) with congenital or traumatic AA instability. METHODS: The AA joint of each dog was surgically stabilized through a dorsal approach using the original or a modified version of the Kishigami AATB...
January 2010: Veterinary Surgery: VS
Eline W Zwitser, Arthur de Gast, Mirjam J A Basie, Folkert J van Kemenade, Barend J van Royen
BACKGROUND: A relatively high incidence of pathological conditions in retrieved femoral heads, including a group of patients having low grade B-cell lymphoma, has been described before. At short term follow up none of these patients with low-grade B-cell lymphoma showed evidence of systemic disease. However, the long term follow up of these patients is not known. METHODS: From November 1994 up to and including December 2005 we screened all femoral heads removed at the time of primary total hip replacement histopathologically and included them in the bone banking protocol according to the guidelines of the American Associations of Tissue Banks (AATB) and the European Association of Musculo-Skeletal Transplantation (EAMST)...
2009: BMC Musculoskeletal Disorders
Frederick M Azar
Secondary sterilization of musculoskeletal allografts may use chemicals, radiation, or combinations of these. No sterilization techniques have been definitively proven to be more effective than others, and their biomechanical and biological effects on allograft tissue remain largely unknown. The current risk of an allograft infection appears to be much less than the risk of infection surrounding the surgical procedure itself. With appropriate donor screening, improved donor testing--including nucleic acid testing (NAT), and adherence to AATB standards--the risk of disease transmission or infections can be eliminated or substantially decreased...
April 2009: Clinics in Sports Medicine
Babak Arjmand, Seyed Hamidreza Aghayan, Parisa Goodarzi, Mohammad Farzanehkhah, Seyed Mohamadjavad Mortazavi, Mohamad Hossein Niknam, Ali Jafarian, Farzin Arjmand, Soheyla Jebelly far
Iranian Tissue Bank prepares a wide range of human tissue homografts such as; heart valve, bone, skin, amniotic membrane and other tissues for different clinical applications. The purpose of this study was to determine the seroprevalence of HTLV in tissue donors. About 1,548 tissue donors were studied during a 5-years period by ELISA assays. HTLV(1,2)-antibodies were tested for all of donors with other tests upon American Association of Tissue Banks (AATB) standards. About 25 (1.61%) out of 1,548 tissue donors were HTLV positive that 17 donors were male and 8 were female (female/male ratio was approximately 47%)...
August 2009: Cell and Tissue Banking
Petra Spröte, Michael J Hynes, Peter Hortschansky, Ekaterina Shelest, Daniel H Scharf, Sandra M Wolke, Axel A Brakhage
The final step of penicillin biosynthesis in the filamentous fungus Aspergillus nidulans is catalysed by isopenicillin N acyltransferase encoded by the aatA gene. Because there is no bacterial homologue, its evolutionary origin remained obscure. As shown here,disruption of aatA still enabled penicillin production. Genome mining led to the discovery of the aatB gene(AN6775.3) which has a similar structure and expression pattern as aatA. Disruption of aatB resulted in a reduced penicillin titre. Surface plasmon resonance analysis and Northern blot analysis indicated that the promoters of both aatA and aatB are bound and regulated by the same transcription factors AnCF and AnBH1f...
October 2008: Molecular Microbiology
William S Pietrzak, Jennifer Woodell-May
Allograft human bone is an integral part of the surgeons' armamentarium and will continue to be for the near future. The intraoperative handling and/or mechanical properties are critical to its function. These properties are significantly influenced by the composition and the structure of the bone, which varies from donor to donor. Published studies of human bone composition use bone derived from a population that may differ from the population of qualified donors from which allograft bone is derived and may not well represent the pool of clinical allograft bone...
July 2005: Journal of Craniofacial Surgery
Elisa Pianigiani, Francesca Ierardi, Francesca Cherubini Di Simplicio, Andrea Andreassi
Skin allografts were first used at the end of the last century by Girdner [Girdner JH. Skin grafting with graft taken from the dead subject. Med Rec (NY) 1881;20:119-20]; however, routine storage of human tissue developed only in the 1930s to 1940s [Webster JP. Refrigerated skin grafts. Ann Surg 1944;120:431-49] when reliable preservation methods became available. The first proper skin bank was the US Navy Skin Bank, set up in 1949 [McCauley RL. The skin Bank. In: Herndon DN, editor. Total burn care. 1st ed...
July 2005: Clinics in Dermatology
M J Joyce
The American Association of Tissue Banks (AATB) is a scientific, not-for-profit, peer-group organization founded in 1976 to facilitate the provision of transplantable tissues of uniform high quality in quantities sufficient to meet national needs. The Association was created well before there was governmental oversight of tissue banking. The organization consists of individuals involved in tissue banking, medical users, and scientists in the field. Current structure consists of a 13-member Board of Governors with specific subgroups including Musculoskeletal, Reproductive, Skin, Tissue Bank Councils and Council of Accredited Tissue Banks...
2000: Cell and Tissue Banking
Franci A Weyts, P Koen Bos, Winand N Dinjens, W Jacco van Doorn, Frans C van Biezen, Harrie Weinans, Jan A Verhaar
Allogeneic, frozen bone is now the most commonly grafted tissue (Norman-Taylor and Villar 1997). Tissue banks collect bone material according to protocols developed with the aim of maintaining osseoinductive properties of grafts as well as preventing transmission of viral or bacterial diseases (Standards from the American Association of Tissue Banks (AATB) or from the European Association for Musculo-skeletal Transplanting (EAMST)). Standard procedures include cryopreservation of tissue at -80 degrees C, which is generally considered to devitalize the bone by killing all cells present, resulting in reduced immunogenicity of the graft...
December 2003: Acta Orthopaedica Scandinavica
(no author information available yet)
Allograft tissues are used for various orthopedic procedures (e.g., ligament reconstruction, meniscal transplantation, and spinal surgery). In 2002, approximately one million allografts were distributed for transplantation (American Association of Tissue Banks [AATB], unpublished data, 2002). Recent reports of allograft-associated infections have prompted evaluation of the processing and quality-control methods employed by tissue processors. This report describes a case of invasive disease with Streptococcus pyogenes (i...
December 5, 2003: MMWR. Morbidity and Mortality Weekly Report
M K Obeng, R L McCauley, J R Barnett, J P Heggers, K Sheridan, S S Schutzler
INTRODUCTION: The availability of cadaveric allograft is often limited by potentially pathogenic microbial organisms. Little data exists on cadaveric allograft discard rates related to positive microbiology. The purpose of this retrospective review was to determine the cadaveric allograft discard rates related positive microbiology and the subsequent breakdown of those organisms involved. METHODS: From January 1995 to June 1997, 1112 donors were screened and procured after informed consent had been obtained...
May 2001: Burns: Journal of the International Society for Burn Injuries
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