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Cd200R

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https://www.readbyqxmd.com/read/27864635/soluble-cd200-correlates-with-interleukin-6-levels-in-sera-of-copd-patients-potential-implication-of-the-cd200-cd200r-axis-in-the-disease-course
#1
Priya Sakthivel, Angele Breithaupt, Marcus Gereke, David A Copland, Christian Schulz, Achim D Gruber, Andrew D Dick, Jens Schreiber, Dunja Bruder
BACKGROUND: COPD represents a multifactorial lung disorder with high morbidity and mortality. Despite intensive research concerning the underlying disease mechanisms, the involvement of the CD200/CD200R axis in supporting or preventing the onset of COPD has not yet been addressed. Since the CD200/CD200R axis is crucially implicated in the maintenance of pulmonary immune homeostasis, we hypothesized that it might be involved in controlling the onset of COPD. METHODS: To address this, we analyzed the serum samples from COPD patients and normal controls for soluble (s) CD200 and correlated the data to COPD-relevant clinical parameters...
November 18, 2016: Lung
https://www.readbyqxmd.com/read/27830533/analysis-of-the-impact-of-cd200-on-phagocytosis
#2
Anthony Lyons, Aedín M Minogue, Raasay S Jones, Orla Fitzpatrick, Janis Noonan, Veronica A Campbell, Marina A Lynch
One factor that impacts on microglial activation is the interaction between the ubiquitously expressed CD200 and CD200R, which is expressed only on microglia in the brain. Decreased signalling through CD200R, when CD200 expression is reduced, results in microglial activation and may, at least in part, explain the increased cell activity that is observed with age, in models of Alzheimer's and Parkinson's disease as well as in the human diseases. There is evidence of increased microglial activation in CD200-deficient mice, and isolated microglia prepared from these mice are more reactive to inflammatory stimuli like Toll-like receptor 2 and 4 agonists, and interferon-γ...
November 9, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27819346/novel-cd200-homologues-isec1-and-isec2-are-gastrointestinal-secretory-cell-specific-ligands-of-inhibitory-receptor-cd200r
#3
Toshiyuki Kojima, Kiichiro Tsuchiya, Shinji Ikemizu, Soichiro Yoshikawa, Yoshinori Yamanishi, Mamoru Watanabe, Hajime Karasuyama
CD200R is an inhibitory receptor expressed on myeloid cells and some lymphoid cells, and plays important roles in negatively regulating immune responses. CD200 is the only known ligand of CD200R and broadly distributed in a variety of cell types. Here we identified novel CD200 homologues, designated iSEC1 and iSEC2, that are expressed exclusively by secretory cell lineages in the gastrointestinal epithelium while authentic CD200 is expressed by none of epithelial cells including secretory cells. Both iSEC1 and iSEC2 could bind to CD200R but not other members of the CD200R family...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27746328/characterization-of-the-potential-allergenicity-of-irradiated-bovine-%C3%AE-lactalbumin-in-a-balb-c-mouse-model
#4
Xuanyi Meng, Xin Li, Jinyan Gao, Hongbing Chen
Bovine α-lactalbumin (ALA) is a known food allergen present in milk to induce anaphylaxis. A previous study demonstrated that irradiated ALA (iALA) decreased the IgE-binding properties and weakened the degranulation capacity of basophils in vitro. The present study aimed to further assess the potential allergenicity of iALA in vivo in a BALB/c mouse model. The mice (n = 10/group) were intragastrically sensitized and orally challenged with either iALA or ALA using cholera toxin as adjuvant. In contrast to the ALA group, the iALA group did not show anaphylactic shock symptoms...
October 13, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27742835/the-torc1-activated-proteins-p70s6k-and-grb10-regulate-il-4-signaling-and-m2-macrophage-polarization-by-modulating-phosphorylation-of-insulin-receptor-substrate-2
#5
Kristi J Warren, Xi Fang, Nagaraj M Gowda, Joshua J Thompson, Nicola M Heller
Lung M2 macrophages are regulators of airway inflammation, associated with poor lung function in allergic asthma. Previously, we demonstrated that IL-4-induced M2 gene expression correlated with tyrosine phosphorylation of the insulin receptor substrate-2 (IRS-2) in macrophages. We hypothesized that negative regulation of IRS-2 activity after IL-4 stimulation is dependent upon serine phosphorylation of IRS-2. Herein, we describe an inverse relationship between tyrosine phosphorylation (Tyr(P)) and serine phosphorylation (Ser(P)) of IRS-2 after IL-4 stimulation...
November 25, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27731341/cd200r-foxp3-mediated-signalling-regulates-microglial-activation
#6
Min-Hee Yi, Enji Zhang, Jwa-Jin Kim, Hyunjung Baek, Nara Shin, Sena Kim, Sang Ryong Kim, Hang-Rae Kim, Sung Joong Lee, Jin Bong Park, Yonghyun Kim, O-Yu Kwon, Young Ho Lee, Sang-Ha Oh, Dong Woon Kim
The heterogeneity of microglial functions have either beneficial or detrimental roles in specific physiological or pathological environments. However, the details of what transcriptional mechanisms induce microglia to take beneficial phenotypes remain unknown. Here, we report that Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 through its receptor (CD200R). Foxp3 expression was up-regulated in microglia activated by excitotoxicity-induced hippocampal neuroinflammation...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27629530/reduction-of-cd200-expression-in-glioma-cells-enhances-microglia-activation-and-tumor-growth
#7
Chih-Yen Wang, Yun-Ti Hsieh, Kuan-Min Fang, Chung-Shi Yang, Shun-Fen Tzeng
CD200, a type I transmembrane glycoprotein, can interact with its receptor CD200R, which plays an inhibitory role in the activation of microglia-the resident macrophages of the central nervous system. In this study, the rat C6 glioma cell line (C6-1) that was previously characterized with high in vivo tumorigenicity was found to generate CD200 mRNA abundantly. However, CD200 expression was barely detected in another C6 glioma cell clone (C6-2) that was previously found to display low tumorigenic behavior. The results from CD200 immunohistochemistry on human glioma tissue array also showed that tumor cells in Grade I-II astrocytoma expressed a lower level of CD200 immunoreactivity than those detected in Grade III-IV glioblastoma multiforme...
December 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27562325/cd200r-a-co-inhibitory-receptor-on-immune-cells-predicts-the-prognosis-of-human-hepatocellular-carcinoma
#8
Haoyu Sun, Jing Xu, Mei Huang, Qiang Huang, Rui Sun, Weihua Xiao, Cheng Sun
The inhibitory CD200:CD200 receptor axis is essential in preventing inflammatory responses during early microbial infection. It was reported in several tumor models that CD200 expression is closely associated to tumor progression and the blockade of this pathway may restore anti-tumor responses. Our study for the first time investigates the role of CD200:CD200R axis in relation to tumor progression and prognosis of human hepatocellular carcinoma. CD200 and CD200R protein expressions were evaluated by immunostaining on liver tissue specimens and we found higher expressions of CD200 and CD200R in HCC patients comparing to healthy controls...
October 2016: Immunology Letters
https://www.readbyqxmd.com/read/27447752/the-mutational-profile-and-infiltration-pattern-of-murine-mlh1-tumors-concurrences-disparities-and-cell-line-establishment-for-functional-analysis
#9
Claudia Maletzki, Franziska Beyrich, Maja Hühns, Ernst Klar, Michael Linnebacher
Mice lines homozygous negative for one of the four DNA mismatch repair (MMR) genes (MLH1, MSH2, PMS2, MSH6) were generated as models for MMR deficient (MMR-D) diseases. Clinically, hereditary forms of MMR-D include Lynch syndrome (characterized by a germline MMR gene defect) and constitutional MMR-D, the biallelic form. MMR-D knockout mice may be representative for both diseases. Here, we aimed at characterizing the MLH1-/- model focusing on tumor-immune microenvironment and identification of coding microsatellite mutations in lymphomas and gastrointestinal tumors (GIT)...
July 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27385779/a-critical-role-for-cd200r-signaling-in-limiting-the-growth-and-metastasis-of-cd200-melanoma
#10
Jin-Qing Liu, Fatemeh Talebian, Lisha Wu, Zhihao Liu, Ming-Song Li, Laichu Wu, Jianmin Zhu, Joseph Markowitz, William E Carson, Sujit Basu, Xue-Feng Bai
CD200 is a cell surface glycoprotein that functions through engaging CD200R on cells of the myeloid lineage and inhibits their functions. Expression of CD200 was implicated in a variety of human cancer cells, including melanoma cells; however, its roles in tumor growth and immunity are not clearly understood. In this study, we used CD200R-deficient mice and the B16 tumor model to evaluate this issue. We found that CD200R-deficient mice exhibited accelerated growth of CD200(+), but not CD200(-), B16 tumors. Strikingly, CD200R-deficient mice receiving CD200(+) B16 cells i...
August 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27342516/-cd200-cd200r-expression-levels-and-its-significance-after-allogeneic-hematopoietic-stem-cell-transplantation
#11
Yue-Hua Huang, Wei Zhang, Hao Cai, Tian-Jiao Li, Jian Li, Bing Han, Jun-Ling Zhuang, Tie-Nan Zhu, Hua-Cong Cai, Dao-Bin Zhou
BACKGROUND: CD200 and its receptor CD200R are both type-1 membrane glycoproteins, which are members of the immunoglobulin superfamily (IgSF). Besides the inhibitory effect on macrophages, CD200/CD200R also play an important role in regulating the regulatory T cells, allergicreaction, autoimmune diseases, allograft, neurological diseases and other autoimmune-related diseases, etc. OBJECTIVE: To investigate the role of CD200 and its receptor in the graft versus host disease (GVHD)...
June 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27213506/cd200-inhibits-inflammatory-response-by-promoting-katp-channel-opening-in-microglia-cells-in-parkinson-s-disease
#12
Yi Ren, Min Ye, Shengdi Chen, Jianqing Ding
BACKGROUND As the second most common neurodegenerative disorder after Alzheimer's disease (AD), Parkinson's disease (PD) principally impacts the motor system in approximately 7 million patients worldwide. The present study aimed to explore the effects of cluster of differentiation (CD200) on adenosine triphosphate-sensitive potassium (KATP) channels and inflammatory response in PD mice. MATERIAL AND METHODS We created an in vivo PD model by intraperitoneal injection of 30 mg/kg/day 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride (MPTP...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27111430/characterization-of-cd200-ectodomain-shedding
#13
Karrie K Wong, Fang Zhu, Ismat Khatri, Qiang Huo, David E Spaner, Reginald M Gorczynski
We have previously reported the existence of a soluble form of CD200 (sCD200) in human plasma, and found sCD200 to be elevated in the plasma of Chronic Lymphocytic Leukemia (CLL) patients. CLL cells release CD200 at a constitutive level, which could be attenuated partially by ADAM28 silencing. In this study, we further explored mechanisms of CD200 shedding beyond that of ADAM28, and performed biochemical analysis of sCD200 using materials derived from purified CLL cells and Hek293 cells stably transfected with CD200, and antibodies generated specifically against either the extracellular or cytoplasmic regions of CD200...
2016: PloS One
https://www.readbyqxmd.com/read/27108386/a-truncated-form-of-cd200-cd200s-expressed-on-glioma-cells-prolonged-survival-in-a-rat-glioma-model-by-induction-of-a-dendritic-cell-like-phenotype-in-tumor-associated-macrophages
#14
Kana Kobayashi, Hajime Yano, Akihiro Umakoshi, Shirabe Matsumoto, Ayano Mise, Yu Funahashi, Yoshitomo Ueno, Yoshiaki Kamei, Yasutsugu Takada, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka
CD200 induces immunosuppression in myeloid cells expressing its receptor CD200R, which may have consequences for tumor immunity. We found that human carcinoma tissues express not only full-length CD200 (CD200L) but also its truncated form, CD200S. Although CD200S is reported to antagonize the immunosuppressive actions of CD200L, the role of CD200S in tumor immunity has never been investigated. We established rat C6 glioma cell lines that expressed either CD200L or CD200S; the original C6 cell line did not express CD200 molecules...
April 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27096058/a-new-insight-into-viral-proteins-as-immunomodulatory-therapeutic-agents-kshv-vox2-a-homolog-of-human-cd200-as-a-potent-anti-inflammatory-protein
#15
REVIEW
Maryam Mousavinezhad-Moghaddam, Abbas Ali Amin, Houshang Rafatpanah, Seyed Abdol Rahim Rezaee
The physiologic function of the immune system is defense against infectious microbes and internal tumour cells, Therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. The mammalian cellular CD200 (OX2)/CD200R interaction is one of such modulatory mechanisms in which myeloid and lymphoid cells are regulated. CD200 and CD200R molecules are membrane proteins that their immunomodulatory effects are able to suppress inflammatory responses, particularly in the privilege sites such as CNS and eyes...
January 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27095555/downregulation-of-cd47-and-cd200-in-patients-with-focal-cortical-dysplasia-type-iib-and-tuberous-sclerosis-complex
#16
Fei-Ji Sun, Chun-Qing Zhang, Xin Chen, Yu-Jia Wei, Song Li, Shi-Yong Liu, Zhen-le Zang, Jiao-Jiang He, Wei Guo, Hui Yang
BACKGROUND: Focal cortical dysplasia type IIb (FCD IIb) and tuberous sclerosis complex (TSC) are well-recognized causes of chronic intractable epilepsy in children. Accumulating evidence suggests that activation of the microglia/macrophage and concomitant inflammatory response in FCD IIb and TSC may contribute to the initiation and recurrence of seizures. The membrane glycoproteins CD47 and CD200, which are highly expressed in neurons and other cells, mediate inhibitory signals through their receptors, signal regulatory protein α (SIRP-α) and CD200R, respectively, in microglia/macrophages...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27055651/%C3%AE-synuclein-vaccination-modulates-regulatory-t-cell-activation-and-microglia-in-the-absence-of-brain-pathology
#17
Josefine R Christiansen, Mads N Olesen, Daniel E Otzen, Marina Romero-Ramos, Vanesa Sanchez-Guajardo
BACKGROUND: Passive and active immunization with α-synuclein has been shown to be neuroprotective in animal models of Parkinson's disease. We have previously shown that vaccination with α-synuclein, long before α-synuclein-induced brain pathology, prevents striatal degeneration by inducing regulatory T cell infiltration in parenchyma and antibody deposition on α-synuclein overexpressing neurons. However, the effect of peripheral α-synuclein on the immune system is unknown, as are the mechanistic changes induced in the CD4 T cell population during successful neuroprotective animal studies...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27009917/among-human-macrophages-polarised-to-different-phenotypes-the-m-csf-oriented-cells-present-the-highest-pro-inflammatory-response-to-the-rheumatoid-arthritis-specific-immune-complexes-containing-acpa
#18
Cyril Clavel, Laurie Ceccato, Florence Anquetil, Guy Serre, Mireille Sebbag
OBJECTIVES: In the inflamed synovium of patients with rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) probably form immune complexes (IC) on deposits of citrullinated fibrin. We showed that in vitro such ACPA-IC activate a pro-inflammatory cytokine response in M-CSF-differentiated macrophages. Our objective was to evaluate how macrophage polarisation influences this response. METHODS: CD14-positive monocytes from healthy donors were cultured in the presence of M-CSF, IFN-γ, interleukin (IL)-4 or IL-10...
March 23, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26923638/constitutively-expressed-siglec-9-inhibits-lps-induced-ccr7-but-enhances-il-4-induced-cd200r-expression-in-human-macrophages
#19
Hiroshi Higuchi, Toru Shoji, Shinji Iijima, Ken-Ichi Nishijima
Siglecs recognize the sialic acid moiety and regulate various immune responses. In the present study, we compared the expression levels of Siglecs in human monocytes and macrophages using a quantitative real-time reverse transcription-polymerase chain reaction analysis. The differentiation of monocytes into macrophages by macrophage colony-stimulating factor or granulocyte macrophage colony-stimulating factor enhanced the expression of Siglec-7 and Siglec-9. The differentiated macrophages were stimulated by lipopolysaccharide (LPS) plus interferon (IFN)-γ or interleukin (IL)-4...
June 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/26891688/cd200r1-agonist-attenuates-glial-activation-inflammatory-reactions-and-hypersensitivity-immediately-after-its-intrathecal-application-in-a-rat-neuropathic-pain-model
#20
Miriam Hernangómez, Ilona Klusáková, Marek Joukal, Ivana Hradilová-Svíženská, Carmen Guaza, Petr Dubový
BACKGROUND: Interaction of CD200 with its receptor CD200R has an immunoregulatory role and attenuates various types of neuroinflammatory diseases. METHODS: Immunofluorescence staining, western blot analysis, and RT-PCR were used to investigate the modulatory effects of CD200 fusion protein (CD200Fc) on activation of microglia and astrocytes as well as synthesis of pro- (TNF, IL-1β, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines in the L4-L5 spinal cord segments in relation to behavioral signs of neuropathic pain after unilateral sterile chronic constriction injury (sCCI) of the sciatic nerve...
2016: Journal of Neuroinflammation
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