keyword
MENU ▼
Read by QxMD icon Read
search

Cd200

keyword
https://www.readbyqxmd.com/read/29144828/prognostic-impact-of-cd200-and-cd56-expression-in-pediatric-b-cell-acute-lymphoblastic-leukemia-patients
#1
Salah Aref, Emad Azmy, Kadry El-Bakry, Lobna Ibrahim, Sherin Abdel Aziz
This study aimed to determine the prognostic impact of CD200 and CD56 expression in pediatric B cell acute lymphoblastic leukemia (B-ALL) patients, both of which have been implicated in immune tolerance and previously suggested as independent risk factors. CD200 has a central role in immune tolerance that protects stem cells and other critical tissues from immune damage. The expression of CD200/CD56 in leukemic blasts were assessed in leukemic blasts before chemotherapy in 43 bone marrow (BM) and/or peripheral blood (PB) samples by flow cytometry...
November 16, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29123134/divergent-proliferation-patterns-of-distinct-human-hair-follicle-epithelial-progenitor-niches-in-situ-and-their-differential-responsiveness-to-prostaglandin-d2
#2
Talveen S Purba, Michael Peake, Bessam Farjo, Nilofer Farjo, Ranjit K Bhogal, Gail Jenkins, Ralf Paus
Human scalp hair follicles (hHF) harbour several epithelial stem (eHFSC) and progenitor cell sub-populations organised into spatially distinct niches. However, the constitutive cell cycle activity of these niches remains to be characterized in situ. Therefore, the current study has studied these characteristics of keratin 15+ (K15), CD200+ or CD34+ cells within anagen VI hHFs by immunohistomorphometry, using Ki-67 and 5-ethynyl-2'-deoxyuridine (EdU). We quantitatively demonstrate in situ the relative cell cycle inactivity of the CD200+/K15+ bulge compared to other non-bulge CD34+ and K15+ progenitor compartments and found that in each recognized eHFSC/progenitor niche, proliferation associates negatively with eHFSC-marker expression...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29104062/stress-disinhibits-microglia-via-down-regulation-of-cd200r-a-mechanism-of-neuroinflammatory-priming
#3
Matthew G Frank, Laura K Fonken, Jessica L Annis, Linda R Watkins, Steven F Maier
Exposure to stressors primes the neuroinflammatory and microglial proinflammatory response to subsequent immune challenges, suggesting that stress might attenuate immunoregulatory mechanisms in the CNS microenvironment. CD200:CD200R is a key immunoregulatory signaling dyad that constrains microglial activation, and disruption of CD200:CD200R signaling primes microglia to subsequent immune challenges. Therefore, the present study examined the mediating role of CD200:CD200R signaling in stress-induced microglial priming...
November 2, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29101474/correction-to-human-cd200-suppresses-macrophage-mediated-xenogeneic-cytotoxicity-and-phagocytosis
#4
Rieko Sakai, Akira Maeda, Thuy-Vy Choi, Pei-Chi Lo, Patmika Jiaravuthisan, Afifah Mod Shabri, Han-Tang Wang, Rei Matsuura, Tasuku Kodama, Hiroshi Eguchi, Hiroomi Okuyama, Shuji Miyagawa
In the original publication, the fifth author name was erroneously published as "Patmika Jiaravuthiasan". The correct author name should read as, "Patmika Jiaravuthisan". The original article was corrected.
November 3, 2017: Surgery Today
https://www.readbyqxmd.com/read/29101312/gingival-tissue-inflammation-promotes-increased-matrix-metalloproteinase-12-production-by-cd200r-low-monocyte-derived-cells-in-periodontitis
#5
Sofia Björnfot Holmström, Reuben Clark, Stephanie Zwicker, Daniela Bureik, Egle Kvedaraite, Eric Bernasconi, Anh Thu Nguyen Hoang, Gunnar Johannsen, Benjamin J Marsland, Elisabeth A Boström, Mattias Svensson
Irreversible tissue recession in chronic inflammatory diseases is associated with dysregulated immune activation and production of tissue degradative enzymes. In this study, we identified elevated levels of matrix metalloproteinase (MMP)-12 in gingival tissue of patients with the chronic inflammatory disease periodontitis (PD). The source of MMP12 was cells of monocyte origin as determined by the expression of CD14, CD68, and CD64. These MMP12-producing cells showed reduced surface levels of the coinhibitory molecule CD200R...
November 3, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29070649/complex-immune-evasion-strategies-in-classical-hodgkin-lymphoma
#6
Frederik Wein, Marc A Weniger, Benedikt Höing, Judith C Arnolds, Andreas Hüttmann, Martin-Leo Hansmann, Sylvia Hartmann, Ralf Küppers
The cellular microenvironment in classical Hodgkin lymphoma (cHL) is dominated by a mixed infiltrate of inflammatory cells with typically only about 1% Hodgkin and Reed/Sternberg (HRS) tumor cells. T cells are usually the largest population of cells in the cHL microenvironment, encompassing T helper (Th) cells, regulatory T (Treg) cells and cytotoxic T cells. Th and Treg cells presumably provide essential survival signals for HRS cells. Treg cells are also involved in rescuing HRS cells from anti-tumor immune responses...
October 25, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29049725/cd11b-and-cd200-on-circulating-monocytes-differentiate-two-angiographic-subtypes-of-polypoidal-choroidal-vasculopathy
#7
COMPARATIVE STUDY
Yousif Subhi, Marie Krogh Nielsen, Christopher Rue Molbech, Akio Oishi, Amardeep Singh, Mogens Holst Nissen, Torben Lykke Sørensen
Purpose: To investigate surface expression of CD11b and CD200 on circulating monocytes in patients with polypoidal choroidal vasculopathy (PCV). Methods: This was a prospective case-control study of patients with PCV (n = 27), age-matched healthy controls (n = 27), and patients with neovascular AMD (n = 49). All participants underwent a comprehensive ocular examination. Fluorescein and indocyanine green angiography were performed in patients suspected of neovascular AMD or PCV...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29042364/a-cd200r-cd28-fusion-protein-appropriates-an-inhibitory-signal-to-enhance-t-cell-function-and-therapy-of-murine-leukemia
#8
Shannon K Oda, Andrew W Daman, Nicolas M Garcia, Felecia Wagener, Thomas M Schmitt, Xiaoxia Tan, Aude G Chapuis, Philip D Greenberg
Acute myeloid leukemia (AML), the most common adult acute leukemia in the U.S., has the poorest survival rate, with 26% of patients surviving 5 years. Adoptive immunotherapy with T cells genetically modified to recognize tumors is a promising and evolving treatment option. However, antitumor activity, particularly in the context of progressive leukemia, can be dampened both by limited costimulation and triggering of immunoregulatory checkpoints that attenuate T cell responses. Expression of CD200 (OX2), a negative regulator of T cell function that binds CD200R, is commonly increased in leukemia and other malignancies, and is associated with poor prognosis in leukemia patients...
October 17, 2017: Blood
https://www.readbyqxmd.com/read/29024461/reproducible-diagnosis-of-chronic-lymphocytic-leukemia-by-flow-cytometry-an-european-research-initiative-on-cll-eric-european-society-for-clinical-cell-analysis-escca-harmonisation-project
#9
Andy C Rawstron, Karl-Anton Kreuzer, Asha Soosapilla, Martin Spacek, Olga Stehlikova, Peter Gambell, Neil McIver-Brown, Neus Villamor, Katherina Psarra, Maria Arroz, Raffaella Milani, Javier de la Serna, M Teresa Cedena, Ozren Jaksic, Josep Nomdedeu, Carol Moreno, Gian Matteo Rigolin, Antonio Cuneo, Preben Johansen, Hans E Johnsen, Richard Rosenquist, Carsten Utoft Niemann, Wolfgang Kern, David Westerman, Marek Trneny, Stephen Mulligan, Michael Doubek, Sarka Pospisilova, Peter Hillmen, David Oscier, Michael Hallek, Paolo Ghia, Emili Montserrat
The diagnostic criteria for CLL rely on morphology and immunophenotype. Current approaches have limitations affecting reproducibility and there is no consensus on the role of new markers. The aim of this project was to identify reproducible criteria and consensus on markers recommended for the diagnosis of CLL. ERIC/ESCCA members classified 14 of 35 potential markers as "required" or "recommended" for CLL diagnosis, consensus being defined as >75% and >50% agreement, respectively. An approach to validate "required" markers using normal peripheral blood was developed...
October 10, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28984300/cd200-expression-in-mantle-cell-lymphoma-identifies-a-unique-subgroup-of-patients-with-frequent-ighv-mutations-absence-of-sox11-expression-and-an-indolent-clinical-course
#10
Zhihong Hu, Yi Sun, Ellen J Schlette, Guilin Tang, Shaoying Li, Jie Xu, C Cameron Yin, Ken H Young, Keyur Pravinchandra Patel, Roberto N Miranda, Maitrayee Goswami, Michael Wang, Jeffrey L Jorgensen, L Jeffrey Medeiros, Sa A Wang
CD200, a marker currently utilized in the diagnosis of B-cell lymphoma, is uniformly positive in chronic lymphocytic leukemia/chronic lymphocytic leukemia, and is usually absent in mantle cell lymphoma. Over a 6 year-period, of 668 mantle cell lymphoma assessed by flow cytometry, CD200 expression was detected in 25 patients (~4%). All 25 patients had bone marrow involvement; however, 11 (44%) patients had no nodal or extranodal disease and belonged to non-nodal leukemic variant mantle cell lymphoma. Morphologically, bone marrow showed an unusual interstitial infiltrative pattern in 14/25 (56%) and small round cells resembling chronic lymphocytic leukemia in 9/25 (36%)...
October 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28981915/trispecific-antibodies-for-cd16a-directed-nk-cell-engagement-and-dual-targeting-of-tumor-cells
#11
Thorsten Gantke, Michael Weichel, Carmen Herbrecht, Uwe Reusch, Kristina Ellwanger, Ivica Fucek, Markus Eser, Thomas Müller, Remko Griep, Vera Molkenthin, Eugene A Zhukovsky, Martin Treder
Bispecific antibodies that redirect the lytic activity of cytotoxic immune effector cells, such as T- and NK cells, onto tumor cells have emerged as a highly attractive and clinically validated treatment modality for hematological malignancies. Advancement of this therapeutic concept into solid tumor indications, however, is hampered by the scarcity of targetable antigens that are surface-expressed on tumor cells but demonstrate only limited expression on healthy tissues. To overcome this limitation, the concept of dual-targeting, i...
September 1, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/28971483/study-of-efficacy-and-safety-of-noncultured-extracted-follicular-outer-root-sheath-cell-suspension-transplantation-in-the-management-of-stable-vitiligo
#12
Pawan Kumar, Neetu Bhari, Manoj K Tembhre, Sujata Mohanty, Sudheer Arava, Vinod K Sharma, Somesh Gupta
BACKGROUND: Noncultured, extracted follicular outer root sheath suspension (NC-EHF-ORS-CS) is a recently introduced technique for the treatment of stable vitiligo. OBJECTIVE: To study the clinical efficacy of this technique and to determine the viability and cell composition of the suspension. METHODS: Twenty-five patients with stable vitiligo were included in this prospective study. Fifty follicles were extracted from occipital scalp and were incubated with trypsin-ethylenediaminetetraacetic acid to separate outer root sheath cells...
October 3, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28968355/role-of-human-cd200-overexpression-in-pig-to-human-xenogeneic-immune-response-compared-with-human-cd47-overexpression
#13
Ji-Jing Yan, Tai Yeon Koo, Han-Sin Lee, Wook-Bin Lee, Bohae Kang, Jae-Ghi Lee, Joon Young Jang, Taishi Fang, Jung-Hwa Ryu, Curie Ahn, Sung Joo Kim, Jaeseok Yang
BACKGROUND: Macrophages play important roles in xenograft rejection. Here, we investigated whether overexpression of human CD200 or CD47 in porcine endothelial cells (PEC) can suppress macrophages activation in xenogeneic immune responses. METHODS: PECs and human macrophages were incubated together, harvested and analyzed for in vitro macrophage phagocytic and cytotoxicity activity, and cytokine release. Next, PEC were injected into renal subcapsular space of humanized mice...
September 29, 2017: Transplantation
https://www.readbyqxmd.com/read/28958947/complete-genomic-characterisation-of-two-novel-poxviruses-wkpv-and-ekpv-from-western-and-eastern-grey-kangaroos
#14
Mark Bennett, Shin-Lin Tu, Chris Upton, Cassie McArtor, Amber Gillett, Tanya Laird, Mark O'Dea
Poxviruses have previously been detected in macropods with cutaneous papillomatous lesions, however to date, no comprehensive analysis of a poxvirus from kangaroos has been performed. Here we report the genome sequences of a western grey kangaroo poxvirus (WKPV) and an eastern grey kangaroo poxvirus (EKPV), named for the host species from which they were isolated, western grey (Macropus fuliginosus) and eastern grey (Macropus giganteus) kangaroos. Poxvirus DNA from WKPV and EKPV was isolated and entire coding genome regions determined through Roche GS Junior and Illumina Miseq sequencing, respectively...
September 27, 2017: Virus Research
https://www.readbyqxmd.com/read/28955985/selective-depletion-of-basophils-ameliorates-immunoglobulin-e-mediated-anaphylaxis
#15
Takeshi Nakamura, Tomohiro Fukaya, Tomofumi Uto, Hideaki Takagi, Keiichi Arimura, Tetsuya Tono, Katsuaki Sato
Basophils, which are the rarest granulocytes, play crucial roles in protective immunity against parasites and development of allergic disorders. Although immunoglobulin (Ig)E-dependent responses via receptor for IgE (FcεRI) in basophils have been extensively studied, little is known about cell surface molecules that are selectively expressed on this cell subset to utilize the elimination in vivo through treatment with monoclonal antibody (mAb). Since CD200 receptor 3 (CD200R3) was exclusively expressed on basophils and mast cells (MCs) using a microarray screening, we have generated anti-CD200R3 mAb recognizing CD200R3A...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28940677/reduced-cd200-expression-is-associated-with-altered-th1-th2-cytokine-production-in-placental-trophoblasts-from-preeclampsia
#16
Jie Xu, Yang Gu, Jingxia Sun, Hui Zhu, David F Lewis, Yuping Wang
PROBLEM: To determine if altered trophoblast CD200 and CD200R expressions promote inflammatory cytokine production in preeclamptic placentas. METHODS OF STUDY: Placental tissue CD200 and CD200R expressions were determined by immunostaining. Tissue sections from first-, second-, and third-trimester, normal term, and preeclamptic placentas were used. CD200 and CD200R expressions and cytokine production of TNFα, sTNFR1, INFγ, IL-4, IL-6, IL-8, and IL-10 were determined in trophoblasts from normal and preeclamptic placentas and in normal trophoblasts transfected with CD200 siRNA...
September 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28928248/carbonic-anhydrase-iii-protects-osteocytes-from-oxidative-stress
#17
Chao Shi, Yuhei Uda, Christopher Dedic, Ehab Azab, Ningyuan Sun, Amira I Hussein, Christopher A Petty, Keertik Fulzele, Maria C Mitterberger-Vogt, Werner Zwerschke, Renata Pereira, Kunzheng Wang, Paola Divieti Pajevic
Osteocytes are master orchestrators of bone remodeling; they control osteoblast and osteoclast activities both directly via cell-to-cell communication and indirectly via secreted factors, and they are the main postnatal source of sclerostin and RANKL (receptor activator of NF-kB ligand), two regulators of osteoblast and osteoclast function. Despite progress in understanding osteocyte biology and function, much remains to be elucidated. Recently developed osteocytic cell lines-together with new genome editing tools-has allowed a closer look at the biology and molecular makeup of these cells...
September 19, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28865180/automated-and-simplified-identification-of-normal-and-abnormal-plasma-cells-in-multiple-myeloma-by-flow-cytometry
#18
Elina Alaterre, Sébastien Raimbault, Jean-Michel Garcia, Thierry Rème, Guilhem Requirand, Bernard Klein, Jérôme Moreaux
BACKGROUND: Multiple myeloma (MM) is an incurable disease characterized by clonal plasma cell (PC) proliferation within the bone marrow (BM). Next-generation flow cytometry has become the reference tool to follow minimal residual disease (MRD). We developed a new simpler and cheaper flow cytometry method to analyze bone marrow samples in patients with MM. METHODS: To identify and characterize abnormal PCs, we designed a simple panel composed of anti-CD38, antikappa, and antilambda light chain antibodies, combined with two antibody pools with the same fluorophore (anti-CD19 and anti-CD27 for the negative pool and anti-CD56, anti-CD117, and anti-CD200 antibodies for the positive pool)...
September 2, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28832948/diagnosis-of-cll-revisited-increased-specificity-by-a-modified-five-marker-scoring-system-including-cd200
#19
Thomas Köhnke, Veronika K Wittmann, Veit L Bücklein, Felix Lichtenegger, Zlatana Pasalic, Wolfgang Hiddemann, Karsten Spiekermann, Marion Subklewe
The modified Matutes score has been the basis for the diagnosis of chronic lymphocytic leukaemia (CLL) by flow cytometry for the past 15 years. To increase the specificity of the current score we systematically evaluated the diagnostic value of established as well as novel markers, such as CD200, in a large cohort of patients with untreated B-cell malignancies (n = 370). Double positivity for CD5 and CD23 was of very high value to differentiate between CLL and non-CLL cases. In addition, lack of FMC7 expression as well as CD79b expression intensity showed high sensitivity (90·4% and 92·3%) with acceptable specificity (74·4% and 76·9%)...
November 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28831252/preparation-characterization-and-transfection-efficiency-of-low-molecular-weight-polyethylenimine-based-nanoparticles-for-delivery-of-the-plasmid-encoding-cd200-gene
#20
Fatemeh Nouri, Hossein Sadeghpour, Reza Heidari, Ali Dehshahri
Various strategies have been utilized to improve both gene transfer efficiency and cell-induced toxicity of polyethylenimine (PEI), the most extensively investigated cationic polymeric vector. In this study, we sought to enhance transfection efficiency of low molecular weight PEI (LMW PEI) while maintaining its low toxicity by cross-linking LMW PEI via succinic acid linker. These modifications were designed to improve the hydrophilic-hydrophobic balance of the polymer, by enhancing the buffering capacity and maintaining low cytotoxic effects of the final conjugate...
2017: International Journal of Nanomedicine
keyword
keyword
65936
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"