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https://www.readbyqxmd.com/read/28073173/expression-of-cd43-in-chronic-lymphoproliferative-leukemias
#1
Marc Sorigué, Jordi Juncà, Edurne Sarrate, Javier Grau
BACKGROUND: CD43 has been used on histological samples for the differential diagnosis of lymphoproliferative disorders but there is scarce data on its use by flow cytometry (FC). We set out to characterize the expression of CD43 by FC in B-cell lymphoproliferative disorders and to determine its possible role in the differential diagnosis of these malignancies. METHODS: We analyzed the expression of CD43 in clonal B-cell lymphoproliferative disorders with exclusive peripheral blood and/or bone marrow involvement based on their Moreau chronic lymphocytic leukemia (CLL) score with particular emphasis on Moreau CLL score 3 (MS3) cases, which often present a diagnostic challenge...
January 10, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28040463/umbilical-cord-tissue-derived-mesenchymal-stromal-cells-maintain-immunomodulatory-and-angiogenic-potencies-after-cryopreservation-and-subsequent-thawing
#2
Rita N Bárcia, Jorge M Santos, Mariana Teixeira, Mariana Filipe, Ana Rita S Pereira, Augusto Ministro, Ana Água-Doce, Manuela Carvalheiro, Maria Manuela Gaspar, Joana P Miranda, Luis Graça, Sandra Simões, Susana Constantino Rosa Santos, Pedro Cruz, Helder Cruz
BACKGROUND AIMS: The effect of cryopreservation on mesenchymal stromal cell (MSC) therapeutic properties has become highly controversial. However, data thus far have indiscriminately involved the assessment of different types of MSCs with distinct production processes. This study assumed that MSC-based products are affected differently depending on the tissue source and manufacturing process and analyzed the effect of cryopreservation on a specific population of umbilical cord tissue-derived MSCs (UC-MSCs), UCX(®)...
December 28, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27994015/newly-formed-endothelial-cells-regulate-myeloid-cell-activity-following-spinal-cord-injury-via-expression-of-cd200-ligand
#3
Merav Cohen, Hila Ben-Yehuda, Ziv Porat, Catarina Raposo, Siamon Gordon, Michal Schwartz
: The central nervous system (CNS) is endowed with several immune-related mechanisms that contribute to its protection and maintenance in homeostasis and under pathology. Here, we discovered an additional mechanism that controls inflammatory responses within the CNS milieu under injurious conditions, involving CD200 ligand (CD200L) expressed by newly-formed endothelial cells. We observed that CD200L is constitutively expressed in the mouse healthy CNS by endothelial cells of the blood-cerebrospinal fluid barrier and of the spinal cord meninges, but not by the endothelium of the blood-spinal cord barrier...
December 19, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27929051/reduced-expression-of-monocyte-cd200r-is-associated-with-enhanced-proinflammatory-cytokine-production-in-sarcoidosis
#4
Simon D Fraser, Laura R Sadofsky, Paul M Kaye, Simon P Hart
In sarcoidosis, the proinflammatory cytokines interferon gamma, tumour necrosis factor and interleukin-6 are released by monocyte-derived macrophages and lymphocytes in the lungs and other affected tissues. Regulatory receptors expressed on monocytes and macrophages act to suppress cytokine production, and reduced expression of regulatory receptors may thus promote tissue inflammation. The aim of this study was to characterise the role of regulatory receptors on blood monocytes in patients with sarcoidosis...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27879516/performance-of-a-commercially-available-mal-antibody-in-the-diagnosis-of-primary-mediastinal-large-b-cell-lymphoma
#5
Michael Gentry, Juraj Bodo, Lisa Durkin, Eric D Hsi
Myelin and lymphocyte (MAL) protein has been previously reported as a highly specific marker for distinguishing primary mediastinal large B-cell lymphoma (PMBL) from diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS). However, there has not been a commercially available MAL antibody for immunohistochemistry. We identified a commercially available MAL monoclonal antibody and evaluated it by immunohistochemistry on 43 cases of PMBL and 63 cases of DLBCL, NOS. We also compared this with a CD200 antibody that was previously reported useful in distinguishing PMBL and DLBCL, NOS...
November 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27877018/more-frequent-igd-and-reduced-cd200-expression-in-chinese-patients-younger-than-50-years-old-with-multiple-myeloma-a-multicenter-analysis
#6
Jin Lu, Jing Lu, Wenming Chen, Jing Wang, Yuliang Huo, Jian Hou, Xiaojun Huang
We retrospectively analyzed the presenting features and survival of 194 newly diagnosed patients with multiple myeloma in the People's Republic of China. Compared with older patients, younger patients had a higher percentage of IgD isotype, lower percentage of International Staging System Stage 3 disease, higher albumin level, and lower frequency of high β2-microglobulin and CD200 expression. There was no difference in sex, Durie-Salmon stage, bone lesion degree, creatinine, lactate dehydrogenase, fluorescence in situ hybridization, and expression of other antigens...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27864635/soluble-cd200-correlates-with-interleukin-6-levels-in-sera-of-copd-patients-potential-implication-of-the-cd200-cd200r-axis-in-the-disease-course
#7
Priya Sakthivel, Angele Breithaupt, Marcus Gereke, David A Copland, Christian Schulz, Achim D Gruber, Andrew D Dick, Jens Schreiber, Dunja Bruder
BACKGROUND: COPD represents a multifactorial lung disorder with high morbidity and mortality. Despite intensive research concerning the underlying disease mechanisms, the involvement of the CD200/CD200R axis in supporting or preventing the onset of COPD has not yet been addressed. Since the CD200/CD200R axis is crucially implicated in the maintenance of pulmonary immune homeostasis, we hypothesized that it might be involved in controlling the onset of COPD. METHODS: To address this, we analyzed the serum samples from COPD patients and normal controls for soluble (s) CD200 and correlated the data to COPD-relevant clinical parameters...
November 18, 2016: Lung
https://www.readbyqxmd.com/read/27836863/checkpoint-proteins-in-pediatric-brain-and-extracranial-solid-tumors-opportunities-for-immunotherapy
#8
REVIEW
Eric K Ring, James M Markert, G Yancey Gillespie, Gregory K Friedman
Pediatric brain and extracranial solid tumors are a diverse group of malignancies that represent almost half of all pediatric cancers. Standard therapy includes various combinations of surgery, cytotoxic chemotherapy, and radiation, which can be very harmful to a developing child, and survivors carry a substantial burden of long-term morbidities. Although these therapies have improved survival rates for children with solid tumors, outcomes still remain extremely poor for subsets of patients. Recently, immunosuppressive checkpoint molecules that negatively regulate immune cell function have been described...
November 10, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27830533/analysis-of-the-impact-of-cd200-on-phagocytosis
#9
Anthony Lyons, Aedín M Minogue, Raasay S Jones, Orla Fitzpatrick, Janis Noonan, Veronica A Campbell, Marina A Lynch
One factor that impacts on microglial activation is the interaction between the ubiquitously expressed CD200 and CD200R, which is expressed only on microglia in the brain. Decreased signalling through CD200R, when CD200 expression is reduced, results in microglial activation and may, at least in part, explain the increased cell activity that is observed with age, in models of Alzheimer's and Parkinson's disease as well as in the human diseases. There is evidence of increased microglial activation in CD200-deficient mice, and isolated microglia prepared from these mice are more reactive to inflammatory stimuli like Toll-like receptor 2 and 4 agonists, and interferon-γ...
November 9, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27819346/novel-cd200-homologues-isec1-and-isec2-are-gastrointestinal-secretory-cell-specific-ligands-of-inhibitory-receptor-cd200r
#10
Toshiyuki Kojima, Kiichiro Tsuchiya, Shinji Ikemizu, Soichiro Yoshikawa, Yoshinori Yamanishi, Mamoru Watanabe, Hajime Karasuyama
CD200R is an inhibitory receptor expressed on myeloid cells and some lymphoid cells, and plays important roles in negatively regulating immune responses. CD200 is the only known ligand of CD200R and broadly distributed in a variety of cell types. Here we identified novel CD200 homologues, designated iSEC1 and iSEC2, that are expressed exclusively by secretory cell lineages in the gastrointestinal epithelium while authentic CD200 is expressed by none of epithelial cells including secretory cells. Both iSEC1 and iSEC2 could bind to CD200R but not other members of the CD200R family...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27784369/-correlation-between-expression-of-cd200-and-regulatory-t-cells-in-multiple-myeloma-and-its-significance-in-prognostic-stratification
#11
Ming-Xia Zhu, Wen-Li Wan, Hai-Shen Li, Yan-Fang Wang, Jing Wang, Hui-Sen Ling, Xin-Xing Yan, Xiao-Yan Ke
OBJECTIVE: To study the correlation between expression of CD200 and regulatory T cells (Tregs) in multiple myeloma(MM) patients and to explore its significance in prognostic stratification. METHODS: CD200 and other immunophenotypes, including CD38, CD138, CD56, CD19, CD20, CD117, cytoplasm light chain Kappa and Lambda in bone marrow samples, and Tregs in peripheral blood were detected by flow cytometry from 78 newly diagnosed MM patients. Serum concentrations of hemoglobin(Hb), β2 microglobulin (β2-MG) and lactate dehydrogenase (LDH) were detected, respectively...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27731341/cd200r-foxp3-mediated-signalling-regulates-microglial-activation
#12
Min-Hee Yi, Enji Zhang, Jwa-Jin Kim, Hyunjung Baek, Nara Shin, Sena Kim, Sang Ryong Kim, Hang-Rae Kim, Sung Joong Lee, Jin Bong Park, Yonghyun Kim, O-Yu Kwon, Young Ho Lee, Sang-Ha Oh, Dong Woon Kim
The heterogeneity of microglial functions have either beneficial or detrimental roles in specific physiological or pathological environments. However, the details of what transcriptional mechanisms induce microglia to take beneficial phenotypes remain unknown. Here, we report that Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 through its receptor (CD200R). Foxp3 expression was up-regulated in microglia activated by excitotoxicity-induced hippocampal neuroinflammation...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27718302/evaluation-of-new-markers-for-minimal-residual-disease-monitoring-in-b-cell-precursor-acute-lymphoblastic-leukemia-cd73-and-cd86-are-the-most-relevant-new-markers-to-increase-the-efficacy-of-mrd-assay
#13
Prashant R Tembhare, Sitaram Ghogale, Nisha Ghatwai, Yajamanam Badrinath, Nikesh Kunder, Nikhil V Patkar, Asma R Bibi, Gaurav Chatterjee, Brijesh Arora, Gaurav Narula, Shripad Banawali, Nilesh Deshpande, Prathibha Amare, Sumeet Gujral, Papagudi G Subramanian
BACKGROUND: Multiparametric flow cytometry (MFC) is a popular technique for minimal residual disease (MRD) analysis. However, its applicability is still limited to 90% of B-cell precursor acute lymphoblastic leukemia (BCPALL) due to two major issues, i.e. a proportion of cases do not express adequate leukemia associated immunophenotype (LAIPs) with currently used markers and drug-induced antigen-modulation. Hence, the incorporation of additional reliable markers is required for the further improvement of MFC-based MRD evaluation...
October 7, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27710895/cd200fc-attenuates-inflammatory-responses-and-maintains-barrier-function-by-suppressing-nf-%C3%AE%C2%BAb-pathway-in-cigarette-smoke-extract-induced-endothelial-cells
#14
Junwei Xu, Lu Lu, Jing Lu, Jihui Xia, Hongjin Lu, Lin Yang, Wensheng Xia, Shihai Shen
BACKGROUND: Recent evidence suggests that CD200 fusion protein (CD200Fc), a CD200R1 agonist may attenuate inflammatory responses in autoimmune diseases and neuro-degeneration. While, little is known about the function of CD200Fc in cigarette smoke extract (CSE)-induced mouse Cardiac Microvascular Endothelial Cells (mCMECs). The present study was designed to elucidate the effects of CD200Fc on CSE-induced vascular endothelial barrier (VEB) dysfunction and inflammatory responses, which is a highly clinically relevant model of smoking related cardiovascular diseases...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27699085/proteomic-analysis-of-the-peri-infarct-area-after-human-umbilical-cord-mesenchymal-stem-cell-transplantation-in-experimental-stroke
#15
He Dongsheng, Zhang Zhuo, Lao Jiamin, Meng Hailan, Han Lijuan, Chen Fan, Ye Dan, Zhang He, Xu Yun
Among various therapeutic approaches for stroke, treatment with human umbilical cord mesenchymal stem cells (hUC-MSCs) has acquired some promising results. However, the underlying mechanisms remain unclear. We analyzed the protein expression spectrum of the cortical peri-infarction region after ischemic stroke followed by treatment with hUC-MSCs, and found 16 proteins expressed differentially between groups treated with or without hUC-MSCs. These proteins were further determined by Gene Ontology term analysis and network with CD200-CD200R1, CCL21-CXCR3 and transcription factors...
October 2016: Aging and Disease
https://www.readbyqxmd.com/read/27629530/reduction-of-cd200-expression-in-glioma-cells-enhances-microglia-activation-and-tumor-growth
#16
Chih-Yen Wang, Yun-Ti Hsieh, Kuan-Min Fang, Chung-Shi Yang, Shun-Fen Tzeng
CD200, a type I transmembrane glycoprotein, can interact with its receptor CD200R, which plays an inhibitory role in the activation of microglia-the resident macrophages of the central nervous system. In this study, the rat C6 glioma cell line (C6-1) that was previously characterized with high in vivo tumorigenicity was found to generate CD200 mRNA abundantly. However, CD200 expression was barely detected in another C6 glioma cell clone (C6-2) that was previously found to display low tumorigenic behavior. The results from CD200 immunohistochemistry on human glioma tissue array also showed that tumor cells in Grade I-II astrocytoma expressed a lower level of CD200 immunoreactivity than those detected in Grade III-IV glioblastoma multiforme...
December 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27607421/cell-homogeneity-indispensable-for-regenerative-medicine-by-cultured-human-corneal-endothelial-cells
#17
Junji Hamuro, Munetoyo Toda, Kazuko Asada, Asako Hiraga, Ursula Schlötzer-Schrehardt, Monty Montoya, Chie Sotozono, Morio Ueno, Shigeru Kinoshita
PURPOSE: To identify the subpopulation (SP) among heterogeneous cultured human corneal endothelial cells (cHCECs) devoid of cell-state transition applicable for cell-based therapy. METHODS: Subpopulation presence in cHCECs was confirmed via surface CD-marker expression level by flow cytometry. CD markers effective for distinguishing distinct SPs were selected by analyzing those on established cHCECs with a small cell area and high cell density. Contrasting features among three typical cHCEC SPs was confirmed by PCR array for extracellular matrix (ECM)...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27577071/expression-of-immune-checkpoints-in-t-cells-of-esophageal-cancer-patients
#18
Xie Jinhua, Wang Ji, Cheng Shouliang, Zheng Liangfeng, Ji Feiyue, Yang Lin, Zhang Yan, Ji Haoming
Inhibition of immune checkpoint proteins (checkpoints) has become a promising anti-esophageal cancer strategy. We here tested expressions of immune checkpoints in human esophageal cancers. Our results showed the expressions of many immune checkpoints, including CD28, CD27, CD137L, programmed death 1 (PD-1), T cell immunoglobulin mucin-3 (TIM-3), T cell Ig and ITIM domain (TIGIT), CD160, cytotoxic T lymphocyte antigen 4 (CTLA-4), CD200, CD137 and CD158, were dysregulated in peripheral T cells of esophageal cancer patients...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27574016/identification-of-cd200-colorectal-cancer-stem-cells-and-their-gene-expression-profile
#19
Shan-Shan Zhang, Zai-Wei Huang, Li-Xuan Li, Jin-Jin Fu, Bing Xiao
CD200 is a cell surface glycoprotein that has been implicated in a variety of human cancer cells. It has been proposed as a cancer stem cell (CSC) marker in colon cancer and is closely related to tumor immunosuppression. However, there is little functional data supporting its role as a true CSC marker, and the mechanism by which CD200 contributes to colorectal cancer has not been elucidated. In the present study, CD200+ and CD200- COLO 205 colorectal cancer cells were sorted out by flow cytometry, and colonosphere formation and Transwell migration assays were performed...
October 2016: Oncology Reports
https://www.readbyqxmd.com/read/27562325/cd200r-a-co-inhibitory-receptor-on-immune-cells-predicts-the-prognosis-of-human-hepatocellular-carcinoma
#20
Haoyu Sun, Jing Xu, Mei Huang, Qiang Huang, Rui Sun, Weihua Xiao, Cheng Sun
The inhibitory CD200:CD200 receptor axis is essential in preventing inflammatory responses during early microbial infection. It was reported in several tumor models that CD200 expression is closely associated to tumor progression and the blockade of this pathway may restore anti-tumor responses. Our study for the first time investigates the role of CD200:CD200R axis in relation to tumor progression and prognosis of human hepatocellular carcinoma. CD200 and CD200R protein expressions were evaluated by immunostaining on liver tissue specimens and we found higher expressions of CD200 and CD200R in HCC patients comparing to healthy controls...
October 2016: Immunology Letters
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