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https://www.readbyqxmd.com/read/28821546/a-supervised-statistical-learning-approach-for-accurate-legionella-pneumophila-source-attribution-during-outbreaks
#1
Andrew H Buultjens, Kyra Y L Chua, Sarah L Baines, Jason Kwong, Wei Gao, Zoe Cutcher, Stuart Adcock, Susan Ballard, Mark B Schultz, Takehiro Tomita, Nela Subasinghe, Glen P Carter, Sacha J Pidot, Lucinda Franklin, Torsten Seemann, Anders Gonçalves Da Silva, Benjamin P Howden, Timothy P Stinear
Public health agencies are increasingly relying on genomics during Legionnaires' disease investigations. However, the causative bacterium (Legionella pneumophila) has an unusual population structure with extreme temporal and spatial genome sequence conservation. Furthermore, Legionnaires' disease outbreaks can be caused by multiple L. pneumophila genotypes in a single source. These factors can confound cluster identification using standard phylogenomic methods. Here, we show that a statistical learning approach based onL...
August 18, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28821197/regional-variability-in-percentage-of-breast-cancers-reported-as-positive-for-her2-in-california-implications-of-patient-demographics-on-laboratory-benchmarks
#2
Chieh-Yu Lin, Eugene E Carneal, Daphne Y Lichtensztajn, Scarlett L Gomez, Christina A Clarke, Kristin C Jensen, Allison W Kurian, Kimberly H Allison
Objectives: The expected regional variability in percent human epidermal growth factor receptor 2 (HER2)-positive breast cancers is not currently clear. Methods: Data from the 2006 to 2011 California Cancer Registry were examined by county and health service area. The influence of demographic and pathologic features was used in a multivariable logistic regression model to compare expected with observed HER2-positive percentages by region. Results: There was significant geographic variation by California counties (11...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28819693/the-mindmap-project-mental-well-being-in-urban-environments-design-and-first-results-of-a%C3%A2-survey-on-healthcare-planning-policies-strategies-and-programmes-that-address-mental-health-promotion-and-mental-disorder-prevention-for-older-people-in-europe
#3
REVIEW
L Neumann, U Dapp, W Jacobsen, F van Lenthe, W von Renteln-Kruse
BACKGROUND: The MINDMAP consortium (2016-2019) aims to identify opportunities provided by the urban environment for the promotion of mental well-being and functioning of older people in Europe by bringing together European cities with urban longitudinal ageing studies: GLOBE, HAPIEE, HUNT, LASA, LUCAS, RECORD, Rotterdam Study, Turin Study. A survey on mental healthcare planning policies and programmes dedicated to older persons covering the range from health promotion to need of nursing care was performed for profound data interpretation in Amsterdam, Eindhoven, Hamburg, Helsinki, Kaunas, Krakow, London, Nord-Trøndelag, Paris, Prague, Rotterdam and Turin...
August 17, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28819630/examining-health-inequalities-in-latvia-a-decade-of-association-between-socioeconomic-position-and-perceived-health-status
#4
Anželika Berķe-Berga, Pavitra Paul, Hannu Valtonen
The relationship between socioeconomic position (SEP) and population health is contextual. This study identifies the determinants of SEP producing health inequalities in the Latvian population. We also estimate the proportional contribution of different socioeconomic strata- (SES-) related determinants in Latvian health inequalities and measure the changes in the relative contributions of such determinants over the period 2005-2015. Using the household survey data (2005-2015), we construct a principal component analysis based SES index...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28819256/fbn30-in-wild%C3%A2-anopheles-gambiae-functions-as-a-pathogen-recognition-molecule-against-clinically-circulating-plasmodium-falciparum-in-malaria-endemic-areas-in-kenya
#5
Guodong Niu, Genwei Zhang, Caio Franca, Yingjun Cui, Stephen Munga, Yaw Afrane, Jun Li
Malaria is a worldwide health problem that affects two-thirds of the world population. Plasmodium invasion of anopheline mosquitoes is an obligatory step for malaria transmission. However, mosquito-malaria molecular interactions in nature are not clear. A genetic variation within mosquito fibrinogen related-protein 30 (FBN30) was previously identified to be associated with Plasmodium falciparum infection in natural Anopheles gambiae populations at malaria endemic areas in Kenya, and reducing FBN30 expression by RNAi makes mosquitoes more susceptible to P...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818812/airborne-ultrafine-particles-in-a-pacific-island-country-characteristics-sources-and-implications-for-human-exposure
#6
C F Isley, P F Nelson, M P Taylor, M Mazaheri, L Morawska, A J Atanacio, E Stelcer, D D Cohen, Anthony L Morrison
The Pacific Islands carry a perception of having clean air, yet emissions from transport and burning activities are of concern in regard to air quality and health. Ultrafine particle number concentrations (PNCs), one of the best metrics to demonstrate combustion emissions, have not been measured either in Suva or elsewhere in the Islands. This work provides insight into PNC variation across Suva and its relationship with particle mass (PM) concentration and composition. Measurements over a short monitoring campaign provide a vignette of conditions in Suva...
August 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28818552/spatial-temporal-and-health-associations-of-eating-alone-a-cross-cultural-analysis-of-young-adults-in-urban-australia-and-japan
#7
Wakako Takeda, Melissa K Melby
Eating alone is driven by social and cultural factors, not solely by individual preferences. In academic research, eating alone is often simply treated as an alternative to social, commensal eating, and little is known about the practice of eating alone itself. This study employs a cross-cultural analysis to explore social and cultural associations of eating alone. The analysis is based on 1) cultural domain data, derived from principal component analysis of freelist responses, a set of words or phrases related to the topic of eating alone; and 2) in-depth interviews with 72 young adults aged 20-40 in urban Australia and Japan...
August 14, 2017: Appetite
https://www.readbyqxmd.com/read/28818242/young-adult-risk-factors-for-cancer-obesity-inflammation-and-sociobehavioral-mechanisms
#8
Yang Claire Yang, Moira P Johnson, Kristen M Schorpp, Courtney E Boen, Kathleen Mullan Harris
INTRODUCTION: The paper assesses social disparities in the burdens of metabolic and inflammatory risks for cancer in the U.S. young adult population and examines psychosocial and behavioral mechanisms in such disparities. METHODS: Using data of 7,889 individuals aged 12-32 years from the National Longitudinal Study of Adolescent to Adult Health from 1994 to 2009, generalized linear models were used to assess the sex, race/ethnicity, and SES differences in the risks of obesity and inflammation, measured by C-reactive protein...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28818072/use-of-hospital-based-health-care-services-among-children-aged-1-through-9%C3%A2-years-who-were-born-very-preterm-a-population-based-study
#9
Søren T Klitkou, Tor Iversen, Hans J Stensvold, Arild Rønnestad
BACKGROUND: Very preterm (VPT) children, with a birth weight below 1500 g or delivered before 32 weeks of gestational age, are at increased risk of poorer long-term health outcomes and higher rates of hospitalization in childhood. However, considerable variation exists in the need for in-hospital care within this population. We assessed the utilization and distribution of hospital-based care from ages 1 through 9 years for a nationwide population. METHODS: This was a population-based cohort of VPT children born in the period 2001-2009...
August 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28817779/the-price-may-not-be-right-the-value-of-comparison-shopping-for-prescription-drugs
#10
Sanjay Arora, Neeraj Sood, Sophie Terp, Geoffrey Joyce
OBJECTIVES: To measure variations in drug prices across and within zip codes that may reveal simple strategies to improve patients' access to prescribed medications. STUDY DESIGN: We compared drug prices at different types of pharmacies across and within local markets. In-store prices were compared with a Web-based service providing discount coupons for prescription medications. Prices were collected for 2 generic antibiotics because most patients have limited experience with them and are less likely to know the price ranges for them...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28817531/bias-confounding-and-interaction-lions-and-tigers-and-bears-oh-my
#11
Thomas R Vetter, Edward J Mascha
Epidemiologists seek to make a valid inference about the causal effect between an exposure and a disease in a specific population, using representative sample data from a specific population. Clinical researchers likewise seek to make a valid inference about the association between an intervention and outcome(s) in a specific population, based upon their randomly collected, representative sample data. Both do so by using the available data about the sample variable to make a valid estimate about its corresponding or underlying, but unknown population parameter...
September 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28817327/violent-death-reporting-in-maryland-demographic-variability-in-data-completeness
#12
Meghan L Smith, Adebola A Akinyemi, Jennifer L Stanley, Clifford S Mitchell
OBJECTIVES: To analyze the completeness of precipitating circumstance information recorded in the Maryland Violent Death Reporting System and identify limitations that could affect the system's utility. METHODS: We reviewed all violent deaths among Maryland residents for the years 2003 through 2014 (n = 19 161). We assessed the presence of precipitating circumstance data (abstracted from medical examiner and police reports) by manner of death and demographic characteristics...
August 17, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28817104/national-and-subnational-population-based-incidence-of-cancer-in-thailand-assessing-cancers-with-the-highest-burdens
#13
Shama Virani, Surichai Bilheem, Wasan Chansaard, Imjai Chitapanarux, Karnchana Daoprasert, Somsak Khuanchana, Atit Leklob, Donsuk Pongnikorn, Laura S Rozek, Surattaya Siriarechakul, Krittika Suwanrungruang, Sukit Tassanasunthornwong, Patravoot Vatanasapt, Hutcha Sriplung
In Thailand, five cancer types-breast, cervical, colorectal, liver and lung cancer-contribute to over half of the cancer burden. The magnitude of these cancers must be quantified over time to assess previous health policies and highlight future trajectories for targeted prevention efforts. We provide a comprehensive assessment of these five cancers nationally and subnationally, with trend analysis, projections, and number of cases expected for the year 2025 using cancer registry data. We found that breast (average annual percent change (AAPC): 3...
August 17, 2017: Cancers
https://www.readbyqxmd.com/read/28816917/factors-associated-with-developmental-behavioral-pediatricians-prescribing-psychotropic-medication-to-children-with-autism-spectrum-disorder-a-study-of-three-dbpnet-sites
#14
Carissa Jackel, Justine Shults, Susan Wiley, Jareen Meinzen-Derr, Marilyn Augustyn, Nathan Blum
OBJECTIVE: Psychotropic medications are frequently prescribed to children with autism spectrum disorder (ASD), but little is known about the prescribing practices of developmental-behavioral pediatricians (DBPs). Our objective was to determine whether clinical site, age, insurance, or comorbidities influenced DBPs prescribing psychotropic medication for children with ASD. METHODS: A retrospective analysis was performed using electronic health record data of all patients with ASD seen at 3 academic developmental-behavioral pediatrics (DBP) clinical programs from January 2010 to December 2011...
August 10, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28816683/cardiorespiratory-model-based-data-driven-approach-for-sleep-apnea-detection
#15
Sandeep Gutta, Qi Cheng, Hoa Nguyen, Bruce Benjamin
Obstructive sleep apnea (OSA) is a chronic sleep disorder affecting millions of people worldwide. Individuals with OSA are rarely aware of the condition and are often left untreated, which can lead to some serious health problems. Nowadays, several low-cost wearable health sensors are available that can be used to conveniently and noninvasively collect a wide range of physiological signals. In this paper, we propose a new framework for OSA detection in which we combine the wearable sensor measurement signals with the mathematical models of the cardiorespiratory system...
August 14, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28816412/motivational-interviewing-to-enhance-treatment-attendance-in-mental-health-settings-a-systematic-review-and-meta-analysis
#16
REVIEW
Petra Lawrence, Paul Fulbrook, Shawn Somerset, Paula Schulz
INTRODUCTION: The stages of change model suggests that individuals seeking treatment are in the 'preparation' or the 'action' stage of change, which is the desired outcome of successful Motivational Interviewing (MI) interventions. MI is known to enhance treatment attendance among individuals with mental health problems. AIM: This study examined the published research on MI as a pre-treatment to enhance attendance among individuals treatment-seeking and non-treatment seeking for mental health issues...
August 17, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28816188/assessment-of-changes-in-nickel-and-chromium-levels-in-the-gingival-crevicular-fluid-during-fixed-orthodontic-treatment
#17
Vinny Bhasin, Swati J Pustake, Viprat Joshi, Anil Tiwari, Meenakshi Bhasin, Ramandeep S Punia
BACKGROUND: Various components of appliances used in fixed orthodontic treatment are fabricated from materials that are highly resistant in nature and have high strength and biocompatibility. Corrosion of materials occurs inside the oral cavity due to numerous environmental or oral factors that act on them. These factors include temperature, pH variation, salivary conditions, mechanical loads, microbiological and enzymatic activity, and various food components. Gingival crevicular fluid (GCF) is the material obtained from the gingival sulcus and might act as a potential source for various biomarkers in the orthodontic setup because inflammatory-induced response is directly related to orthodontic forces in GCF...
August 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28815169/technical-efficiency-of-rural-primary-health-care-system-for-diabetes-treatment-in-iran-a-stochastic-frontier-analysis
#18
Mostafa Qorbani, Farshad Farzadfar, Reza Majdzadeh, Kazem Mohammad, Abbas Motevalian
BACKGROUND: Our aim was to explore the technical efficiency (TE) of the Iranian rural primary healthcare (PHC) system for diabetes treatment coverage rate using the stochastic frontier analysis (SFA) as well as to examine the strength and significance of the effect of human resources density on diabetes treatment. METHODS: In the SFA model diabetes treatment coverage rate, as a output, is a function of health system inputs (Behvarz worker density, physician density, and rural health center density) and non-health system inputs (urbanization rate, median age of population, and wealth index) as a set of covariates...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28815148/spatio-temporal-analysis-for-new-york-state-sparcs-data
#19
Xin Chen, Yu Wang, Elinor Schoenfeld, Mary Saltz, Joel Saltz, Fusheng Wang
Increased accessibility of health data provides unique opportunities to discover spatio-temporal patterns of diseases. For example, New York State SPARCS (Statewide Planning and Research Cooperative System) data collects patient level detail on patient demographics, diagnoses, services, and charges for each hospital inpatient stay and outpatient visit. Such data also provides home addresses for each patient. This paper presents our preliminary work on spatial, temporal, and spatial-temporal analysis of disease patterns for New York State using SPARCS data...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28815121/enhancing-electronic-health-record-data-with-geospatial-information
#20
Sherrie Xie, Rebecca Greenblatt, Michael Z Levy, Blanca E Himes
Electronic Health Record (EHR)-derived data is a valuable resource for research, and efforts are underway to overcome some of its limitations by using data from external sources to gain a fuller picture of patient characteristics, symptoms, and exposures. Our goal was to assess the utility of augmenting EHR data with geocoded patient addresses to identify geospatial variation of disease that is not explained by EHR-derived demographic factors. Using 2011-2014 encounter data from 27,604 University of Pennsylvania Hospital System asthma patients, we identified factors associated with asthma exacerbations: risk was higher in female, black, middle aged to elderly, and obese patients, as well as those with positive smoking history and with Medicare or Medicaid vs...
2017: AMIA Summits on Translational Science Proceedings
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