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https://www.readbyqxmd.com/read/29327578/rapid-light-driven-color-transition-of-novel-photo-responsive-polydiacetylene-molecules
#1
Jiseok Lee, Sungbaek Seo, Jinsang Kim
We developed new photo-responsive polydiacetylene (PR-PDA) molecules by incorporating a photo-cleavable moiety, 6-nitropiperonyl alcohol (NP) or 4, 5-dimethoxy-2-nitrobenzyl alcohol (DMN), into a self-assembling diacetylene molecule. Inducing steric disordering of the assembled PDA molecules by the cleavage of the photo-responsive moiety under 365 nm UV irradiation results in color transition from blue to red and development of red fluorescence, allowing convenient photo patterning. Further writing and erasing of fluorescence patterns are demonstrated toward novel secure information communication and anti-counterfeiting applications...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29323626/a-scenario-based-cognitive-behavioral-therapy-mobile-app-to-reduce-dysfunctional-beliefs-in-individuals-with-depression-a-randomized-controlled-trial
#2
Ji-Won Hur, Boram Kim, Dasom Park, Sung-Won Choi
INTRODUCTION: While self-administered mobile app-based cognitive behavioral therapy (CBT) has shown efficiency and effectiveness over the past decade, attempts to address automatic and negative beliefs have been lacking. The purpose of this study was to introduce and verify a mobile app that directly intervenes in dysfunctional thoughts. This app-based treatment includes recognizing automatic and negative thoughts of the protagonist of scenarios, writing advice directly to the main character, and sharing advice provided by other participants...
January 11, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29321709/the-probable-prevalence-and-sociodemographic-characteristics-of-specific-learning-disorder-in-primary-school-children-in-edirne
#3
Işık Görker, Leyla Bozatli, Ümran Korkmazlar, Meltem Yücel Karadağ, Cansın Ceylan, Ceren Söğüt, Hasan Cem Aykutlu, Büşra Subay, Nesrin Turan
Introduction: The aim of this study was to research the probable prevalence of Specific Learning Disorder (SLD) in primary school children in Edirne City and the relationships with their sociodemographic characteristics. Methods: The sample of our study was composed of 2,174 children who were educated in primary schools in second, third, and fourth grades in the academic year 2013-2014 in Edirne City. The teachers and parents of these children were given Specific Learning Difficulties Symptom Scale, Learning Disabilities Symptoms Checklist (teacher and parent forms), and sociodemographic data forms to fill in...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29295020/disclosing-sex-trading-histories-to-providers-barriers-and-facilitators-to-navigation-of-social-services-among-women-impacted-by-commercial-sexual-exploitation
#4
Lara Gerassi, Tonya E Edmond, Vanessa Fabbre, Abby Howard, Andrea J Nichols
Sex trafficking and commercial sexual exploitation (CSE) can lead to devastating health and mental health consequences for women, such as elevated rates of substance use, trauma, posttraumatic stress disorder, depression, sexually transmitted infections (STIs), and HIV. Consequently, engagement with services that address addiction, mental health, and housing, and provide general advocacy is critically important to women's increased safety, stabilization, and quality of life. The purpose of this study is to identify perceived barriers and facilitators to service access and engagement with social services among women involved in CSE...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29290922/gestational-diabetes-from-a-to-z
#5
REVIEW
AbdelHameed Mirghani Dirar, John Doupis
Gestational diabetes mellitus (GDM) is defined as any degree of hyperglycaemia that is recognized for the first time during pregnancy. This definition includes cases of undiagnosed type 2 diabetes mellitus (T2DM) identified early in pregnancy and true GDM which develops later. GDM constitutes a greater impact on diabetes epidemic as it carries a major risk of developing T2DM to the mother and foetus later in life. In addition, GDM has also been linked with cardiometabolic risk factors such as lipid abnormalities, hypertensive disorders and hyperinsulinemia...
December 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/29276198/the-fashioning-of-fashionable-diseases-in-the-eighteenth-century
#6
David E Shuttleton
This essay considers why the eighteenth century has particular significance for anyone concerned with the cultural forces necessary to render a disease fashionable. A brief overview of a pervasive cult of sensibility addresses the role of popular medical writing, imaginative literature, and spas in circulating a romanticized model of nervous disorders as signs of intellectual and moral superiority. Attention is drawn to the ambiguity in the term "fashionable" implying "popular," but also something that might be contrived; to what extent were Georgian fashionable diseases merely cultural constructs? Here the medicalization of masturbation suggests a limit-case...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/29232042/evaluation-of-visual-motion-perception-ability-in-mice-with-knockout-of-the-dyslexia-candidate-susceptibility-gene-dcdc2
#7
Amanda R Rendall, Peter A Perrino, Joseph J LoTurco, R Holly Fitch
Developmental dyslexia is a heritable disability characterized by difficulties in learning to read and write that cannot be explained by comorbid factors such as intellectual impairment, lack of educational opportunity, or other neurological disorders (e.g. epilepsy or primary sensory impairments (blindness, deafness)). Dyslexia is considered a common neurodevelopmental disorder, affecting 5%-12% of the population (Lyon, Shaywitz & Shaywitz, 2003; Peterson & Pennington, 2012). It is also a highly heterogeneous disorder, with varied intermediate phenotypes, that include visual and cross-modal integration deficits...
December 12, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29227237/sexual-orientation-self-concept-ambiguity-and-alcohol-use-disorder-symptomology-the-roles-of-motivated-psychological-distancing-and-drinking-to-cope
#8
David W Hancock, Amelia E Talley, Jennifer Bohanek, Micah D Iserman, Molly Ireland
OBJECTIVE: Women whose sexual identity is not exclusively heterosexual are at risk for alcohol use disorder (AUD) and problematic drinking. A textual analytic approach focusing on motivated psychological distancing in language style use was used to detect sexual minority women who are at greatest risk for an AUD. METHOD: Young adult women (N = 254) were asked to complete a self-report measure of sexual orientation self-concept ambiguity as well as free-write about their sexuality...
January 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29225908/an-unusual-presentation-of-tyrosine-hydroxylase-deficiency
#9
Linn E Katus, Steven J Frucht
Background: Dopa-responsive dystonia (DRD) has largely been associated with autosomal dominant mutations in the GCH1 gene leading to GTP cyclohydrolase 1 deficiency. More recently, a deficiency in tyrosine hydroxylase (TH) has been recognized to cause DRD. This is a rare disorder resulting from genetic mutations in the TH gene on chromosome 11. The phenotype ranges from DRD with complete resolution on levodopa to infantile parkinsonism and encephalopathy only partially responsive to levodopa...
2017: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/29223112/development-of-the-handwriting-legibility-scale-hls-a-preliminary-examination-of-reliability-and-validity
#10
Anna L Barnett, Mellissa Prunty, Sara Rosenblum
BACKGROUND: Demands for the production of legible handwriting produced in a timely manner increase as children progress through school. Despite the considerable number of children faced with handwriting difficulties, there is no quick and practical tool to assess legibility in this population. AIM: The aim of this study was to develop the Handwriting Legibility Scale (HLS) and to establish the scale's reliability and validity. METHODS: The HLS is a non-language dependent scale which assesses global legibility, based on five criteria applied to samples of 'free writing'...
December 6, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29222399/pediatric-disorders-of-orthostatic-intolerance
#11
REVIEW
Julian M Stewart, Jeffrey R Boris, Gisela Chelimsky, Phillip R Fischer, John E Fortunato, Blair P Grubb, Geoffrey L Heyer, Imad T Jarjour, Marvin S Medow, Mohammed T Numan, Paolo T Pianosi, Wolfgang Singer, Sally Tarbell, Thomas C Chelimsky
Orthostatic intolerance (OI), having difficulty tolerating an upright posture because of symptoms or signs that abate when returned to supine, is common in pediatrics. For example, ∼40% of people faint during their lives, half of whom faint during adolescence, and the peak age for first faint is 15 years. Because of this, we describe the most common forms of OI in pediatrics and distinguish between chronic and acute OI. These common forms of OI include initial orthostatic hypotension (which is a frequently seen benign condition in youngsters), true orthostatic hypotension (both neurogenic and nonneurogenic), vasovagal syncope, and postural tachycardia syndrome...
December 8, 2017: Pediatrics
https://www.readbyqxmd.com/read/29216968/gender-trouble-the-world-health-organization-the-international-statistical-classification-of-diseases-and-related-health-problems-icd-11-and-the-trans-kids
#12
Sam Winter
The World Health Organization (WHO) is revising its diagnostic manual, the International Statistical Classification of Diseases and Related Health Problems (ICD). At the time of writing, and based on recommendations from its ICD Working Group on Sexual Disorders and Sexual Health, WHO is proposing a new ICD chapter titled Conditions Related to Sexual Health, and that the gender incongruence diagnoses (replacements for the gender identity disorder diagnoses used in ICD-10) should be placed in that chapter. WHO is proposing that there should be a Gender incongruence of childhood (GIC) diagnosis for children below the age of puberty...
October 2017: Sexual Health
https://www.readbyqxmd.com/read/29216238/mother-infant-interaction-assessment-at-discharge-and-at-6-months-in-a-french-cohort-of-infants-born-very-preterm-the-olimpe-study
#13
Gilles Cambonie, Jean-Baptiste Muller, Virginie Ehlinger, Joël Roy, Antoine Guédeney, Cécile Lebeaux, Monique Kaminski, Corine Alberge, Sophie Denizot, Pierre-Yves Ancel, Catherine Arnaud
OBJECTIVES: The principal aim was to investigate the feasibility of assessing mother-infant interactions at discharge and at 6 months infant corrected age in singletons born before 32 weeks of gestation. The secondary aims were to describe these interactions and their disorders, explore the association between maternal emotional state and the interactions, and assess the relationship between disordered interactions and infant social withdrawal behaviour. METHODS: OLIMPE is an ancillary study of the population-based study EPIPAGE 2, which recruited preterm neonates in France in 2011...
2017: PloS One
https://www.readbyqxmd.com/read/29213492/bells-test-are-there-differences-in-performance-between-adult-groups-aged-40-59-and-60-75
#14
Silvio Cesar Escovar Paiva, Vanisa Fante Viapiana, Caroline de Oliveira Cardoso, Rochele Paz Fonseca
Objective: To verify whether differences exist between groups of Brazilian adults aged 40-59 and 60-75 in respective performance on the Bells Test, given the dearth of literature investigating the relationship between focused visual attention and the age factor. Methods: Eighty-four neurologically healthy adults (half aged 40-59 and half 60-75) with high educational level (40-59 years group: M=17.75 years' education; SD=4.00; 60-75 years group: M=15.85 years education; SD=3...
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213296/comparison-of-the-characteristics-of-suicide-attempters-with-major-depressive-disorder-and-those-with-no-psychiatric-diagnosis-in-emergency-departments-of-general-hospitals-in-china
#15
Shengnan Wei, Haiyan Li, Jinglin Hou, Wei Chen, Xu Chen, Xiaoxia Qin
Background: Major depressive disorder (MDD) is a known major risk factor for suicide due to the high suicide mortality. However, studies comparing the characteristics of suicide attempters with major depressive disorder and those with no psychiatric diagnosis in China are very limited. This study examined and compared the sociodemographic and psychological characteristics of suicide attempters with MDD and those with no psychiatric diagnosis in emergency departments of general hospitals to better understand the risk factors for suicide attempts in China...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29204208/pallister-hall-syndrome
#16
Sadanandvalli Retnaswami Chandra, Mane Maheshkumar Daryappa, M A Mukheem Mudabbir, M Pooja, A Arivazhagan
Polydactyly is a relatively common abnormality in infants. However, it can be a marker of a wide variety of neurological and systemic abnormality. Hence, it is important for pediatrician and physician to have insight into the various association of this apparently innocuous anomaly. In this write-up, we report an extremely rare syndrome associated with polydactyly that is Pallister-Hall syndrome. A 10-month-old male child born by lower segment cesarean section presented with global delay associated with microcephaly, frontal bossing, hypertelorism, flat nose, short philtrum, incomplete cleft in the upper lip and hard palate, polydactyly, and syndactyly...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29201552/atp2c2-and-dyx1c1-are-putative-modulators-of-dyslexia-related-mmr
#17
Bent Müller, Gesa Schaadt, Johannes Boltze, Frank Emmrich, Michael A Skeide, Nicole E Neef, Indra Kraft, Jens Brauer, Angela D Friederici, Holger Kirsten, Arndt Wilcke
Background: Dyslexia is a specific learning disorder affecting reading and spelling abilities. Its prevalence is ~5% in German-speaking individuals. Although the etiology of dyslexia largely remains to be determined, comprehensive evidence supports deficient phonological processing as a major contributing factor. An important prerequisite for phonological processing is auditory discrimination and, thus, essential for acquiring reading and spelling skills. The event-related potential Mismatch Response (MMR) is an indicator for auditory discrimination capabilities with dyslexics showing an altered late component of MMR in response to auditory input...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29201538/vision-in-stroke-cohort-profile-overview-of-visual-impairment
#18
Fiona J Rowe
Aim: To profile the full range of visual disorders from a large prospective observation study of stroke survivors referred by stroke multidisciplinary teams to orthoptic services with suspected visual problems. Methods: Multicenter prospective study undertaken in 20 acute Trust hospitals. Standardized screening/referral forms and investigation forms documented data on referral signs and symptoms plus type and extent of visual impairment. Results: Of 1,345 patients referred with suspected visual impairment, 915 were recruited (59% men; mean age at stroke onset 69 years [SD 14])...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29200477/evolutionary-algorithm-optimization-of-biological-learning-parameters-in-a-biomimetic-neuroprosthesis
#19
S Dura-Bernal, S A Neymotin, C C Kerr, S Sivagnanam, A Majumdar, J T Francis, W W Lytton
Biomimetic simulation permits neuroscientists to better understand the complex neuronal dynamics of the brain. Embedding a biomimetic simulation in a closed-loop neuroprosthesis, which can read and write signals from the brain, will permit applications for amelioration of motor, psychiatric, and memory-related brain disorders. Biomimetic neuroprostheses require real-time adaptation to changes in the external environment, thus constituting an example of a dynamic data-driven application system. As model fidelity increases, so does the number of parameters and the complexity of finding appropriate parameter configurations...
March 2017: IBM Journal of Research and Development
https://www.readbyqxmd.com/read/29184481/cynefin-as-reference-framework-to-facilitate-insight-and-decision-making-in-complex-contexts-of-biomedical-research
#20
Gerd Kempermann
The Cynefin scheme is a concept of knowledge management, originally devised to support decision making in management, but more generally applicable to situations, in which complexity challenges the quality of insight, prediction, and decision. Despite the fact that life itself, and especially the brain and its diseases, are complex to the extent that complexity could be considered their cardinal feature, complex problems in biomedicine are often treated as if they were actually not more than the complicated sum of solvable sub-problems...
2017: Frontiers in Neuroscience
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