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https://www.readbyqxmd.com/read/27899401/neonatal-and-childhood-neurodevelopmental-health-and-educational-outcomes-of-children-exposed-to-antidepressants-and-maternal-depression-during-pregnancy-protocol-for-a-retrospective-population-based-cohort-study-using-linked-administrative-data
#1
Deepa Singal, Marni Brownell, Dan Chateau, Chelsea Ruth, Laurence Y Katz
INTRODUCTION: Antidepressants are commonly prescribed during pregnancy; however, there are inconsistent data on the safety of these medications during the prenatal period. To address this gap, this study will investigate short-term and long-term neurodevelopmental, physical and mental health, and educational outcomes of children who have been exposed to selective serotonin reuptake inhibitors (SSRIs) or selective serotonin norepinephrine reuptake inhibitors (SNRIs) and/or maternal depression during pregnancy...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27891100/a-review-about-functional-illiteracy-definition-cognitive-linguistic-and-numerical-aspects
#2
REVIEW
Réka Vágvölgyi, Andra Coldea, Thomas Dresler, Josef Schrader, Hans-Christoph Nuerk
Formally, availability of education for children has increased around the world over the last decades. However, despite having a successful formal education career, adults can become functional illiterates. Functional illiteracy means that a person cannot use reading, writing, and calculation skills for his/her own and the community's development. Functional illiteracy has considerable negative effects not only on personal development, but also in economic and social terms. Although functional illiteracy has been highly publicized in mass media in the recent years, there is limited scientific knowledge about the people termed functional illiterates; definition, assessment, and differential diagnoses with respect to related numerical and linguistic impairments are rarely studied and controversial...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27864833/structured-clinical-documentation-in-the-electronic-medical-record-to-improve-quality-and-to-support-practice-based-research-in-epilepsy
#3
Jaishree Narayanan, Sofia Dobrin, Janet Choi, Susan Rubin, Anna Pham, Vimal Patel, Roberta Frigerio, Darryck Maurer, Payal Gupta, Lourdes Link, Shaun Walters, Chi Wang, Yuan Ji, Demetrius M Maraganore
OBJECTIVE: Using the electronic medical record (EMR) to capture structured clinical data at the point of care would be a practical way to support quality improvement and practice-based research in epilepsy. METHODS: We describe our stepwise process for building structured clinical documentation support tools in the EMR that define best practices in epilepsy, and we describe how we incorporated these toolkits into our clinical workflow. RESULTS: These tools write notes and capture hundreds of fields of data including several score tests: Generalized Anxiety Disorder-7 items, Neurological Disorders Depression Inventory for Epilepsy, Epworth Sleepiness Scale, Quality of Life in Epilepsy-10 items, Montreal Cognitive Assessment/Short Test of Mental Status, and Medical Research Council Prognostic Index...
November 19, 2016: Epilepsia
https://www.readbyqxmd.com/read/27860478/-gene-therapy-for-inherited-retinal-and-optic-nerve-disorders-current-knowledge
#4
Ľ Ďuďáková, B Kousal, H Kolářová, L Hlavatá, P Lišková
The aim of this review is to provide a comprehensive summary of current gene therapy clinical trials for monogenic and optic nerve disorders.The number of genes for which gene-based therapies are being developed is growing. At the time of writing this review gene-based clinical trials have been registered for Leber congenital amaurosis 2 (LCA2), retinitis pigmentosa 38, Usher syndrome 1B, Stargardt disease, choroideremia, achromatopsia, Leber hereditary optic neuropathy (LHON) and X-linked retinoschisis. Apart from RPE65 gene therapy for LCA2 and MT-ND4 for LHON which has reached phase III, all other trials are in investigation phase I and II, i...
2016: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/27849243/moyamoya-disease-impact-on-the-performance-of-oral-and-written-language
#5
Dionísia Aparecida Cusin Lamônica, Camila da Costa Ribeiro, Plínio Marcos Duarte Pinto Ferraz, Maria de Lourdes Merighi Tabaquim
Moyamoya disease is an unusual form of occlusive, cerebrovascular disorder that affects the arteries of the central nervous system, causing acquired language alterations and learning difficulties. The study aim was to describe the oral/written language and cognitive skills in a seven-year-and-seven-month-old girl diagnosed with Moyamoya disease. The assessment consisted of interviews with her parents and application of the following instruments: Observation of Communicative Behavior, Peabody Picture Vocabulary Test, Academic Performance Test, Profile of Phonological Awareness, Raven's Progressive Matrices Test, Special Scale, Wechsler Intelligence Scale for Children, Bender Visual Motor Gestalt Test, and Wisconsin Card Sorting Test...
September 2016: CoDAS
https://www.readbyqxmd.com/read/27842736/-multidimensionality-of-inner-speech-and-its-relationship-with-abnormal-perceptions
#6
William Tamayo-Agudelo, Juan David Vélez-Urrego, Gilberto Gaviria-Castaño, Salvador Perona-Garcelán
BACKGROUND: Inner speech is a common human experience. Recently, there have been studies linking this experience with cognitive functions, such as problem solving, reading, writing, autobiographical memory, and some disorders, such as anxiety and depression. In addition, inner speech is recognised as the main source of auditory hallucinations. OBJECTIVES: The main purpose of this study is to establish the factor structure of Varieties of Inner Speech Questionnaire (VISQ) in a sample of the Colombian population...
October 2016: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/27832925/ecological-validity-of-the-german-bruininks-oseretsky-test-of-motor-proficiency-2nd-edition
#7
Sabine Vinçon, Dido Green, Rainer Blank, Ekkehart Jenetzky
The diagnosis of Developmental Coordination Disorder (DCD) is based on poor motor coordination in the absence of other neurological disorders. In order to identify the presence of movement difficulties, a standardised motor assessment is recommended to determine the extent of movement problems which may contribute to deficits in daily task performance. A German version of the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (German BOT-2) was recently published. This study aimed to determine the ecological validity of the German BOT-2 by considering the relationship between assessment of fundamental motor skills with the BOT-2 and performance of everyday motor activities as evaluated by parents...
November 7, 2016: Human Movement Science
https://www.readbyqxmd.com/read/27831738/correction-to-krupnick-et-al-2016
#8
(no author information available yet)
Reports an error in "An Internet-Based Writing Intervention for PTSD in Veterans: A Feasibility and Pilot Effectiveness Trial" by Janice L. Krupnick, Bonnie L. Green, Richard Amdur, Adil Aloui, Anas Beloui, Erika Roberge, David Cueva, Miguel Roberts, Elizabeth Melnikoff and Mary Ann Dutton (Psychological Trauma: Theory, Research, Practice, and Policy, Advanced Online Publication, Sep 8, 2016, np). (The following abstract of the original article appeared in record 2016-43134-001.) Objective: Veterans suffering from posttraumatic stress disorder (PTSD) may avoid or fail to follow through with a full course of face-to-face mental health treatment for a variety of reasons...
November 10, 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27816923/cryopreservation-of-ovarian-tissue-for-fertility-preservation-in-a-large-cohort-of-young-girls-focus-on-pubertal-development
#9
A K Jensen, C Rechnitzer, K T Macklon, M R S Ifversen, N Birkebæk, N Clausen, K Sørensen, J Fedder, E Ernst, C Yding Andersen
STUDY QUESTION: Is there an association between the need for medical puberty induction and the diagnosis or treatment received in girls who have undergone cryopreservation of ovarian tissue for fertility preservation? SUMMARY ANSWER: There was a clear association between the intensity of treatment received and requirement for medical puberty induction but no association with the diagnosis. WHAT IS KNOWN ALREADY: Although it cannot be predicted which girls will become infertile or develop premature ovarian insufficiency (POI) following intensive chemotherapy or irradiation, patients who are at high risk of POI should be offered ovarian tissue cryopreservation (OTC)...
November 5, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27816800/interventions-that-target-improvements-in-mental-health-for-parents-of-children-with-autism-spectrum-disorders-a-narrative-review
#10
REVIEW
Nikko S Da Paz, Jan L Wallander
Prevalence of autism spectrum disorders (ASD) suggest that one in 68 children is affected. With convincing evidence that parenting a child with ASD is associated with elevated distress and mental health problems, researchers have begun to investigate treatments that directly target parents' psychological well-being. We conducted a narrative review of studies that empirically tested the effects of interventions targeting improvements in the mental health of parents of children with ASD. Following a range of search strategies, a total of 13 studies, seven randomized controlled trials (RCTs) and six pre-post test designs, met inclusion criteria...
October 27, 2016: Clinical Psychology Review
https://www.readbyqxmd.com/read/27809572/identification-of-two-heritable-cross-disorder-endophenotypes-for-tourette-syndrome
#11
Sabrina M Darrow, Matthew E Hirschtritt, Lea K Davis, Cornelia Illmann, Lisa Osiecki, Marco Grados, Paul Sandor, Yves Dion, Robert King, David Pauls, Cathy L Budman, Danielle C Cath, Erica Greenberg, Gholson J Lyon, Dongmei Yu, Lauren M McGrath, William M McMahon, Paul C Lee, Kevin L Delucchi, Jeremiah M Scharf, Carol A Mathews
OBJECTIVE: Phenotypic heterogeneity in Tourette syndrome is partly due to complex genetic relationships among Tourette syndrome, obsessive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD). Identifying symptom-based endophenotypes across diagnoses may aid gene-finding efforts. METHOD: Assessments for Tourette syndrome, OCD, and ADHD symptoms were conducted in a discovery sample of 3,494 individuals recruited for genetic studies. Symptom-level factor and latent class analyses were conducted in Tourette syndrome families and replicated in an independent sample of 882 individuals...
November 4, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27807392/the-impact-of-handwriting-difficulties-on-compositional-quality-in-children-with-developmental-coordination-disorder
#12
Mellissa M Prunty, Anna L Barnett, Kate Wilmut, Mandy S Plumb
INTRODUCTION: There is substantial evidence to support the relationship between transcription skills (handwriting and spelling) and compositional quality. For children with developmental coordination disorder, handwriting can be particularly challenging. While recent research has aimed to investigate their handwriting difficulties in more detail, the impact of transcription on their compositional quality has not previously been examined. The aim of this exploratory study was to examine compositional quality in children with developmental coordination disorder and to ascertain whether their transcription skills influence writing quality...
October 2016: British Journal of Occupational Therapy
https://www.readbyqxmd.com/read/27799745/pathophysiology-of-visual-disorders-induced-by-phosphodiesterase-inhibitors-in-the-treatment-of-erectile-dysfunction
#13
REVIEW
Marilita M Moschos, Eirini Nitoda
AIM: The aim of this review was to summarize the ocular action of the most common phosphodiesterase (PDE) inhibitors used for the treatment of erectile dysfunction and the subsequent visual disorders. METHOD: This is a literature review of several important articles focusing on the pathophysiology of visual disorders induced by PDE inhibitors. RESULTS: PDE inhibitors have been associated with ocular side effects, including changes in color vision and light perception, blurred vision, transient alterations in electroretinogram (ERG), conjunctival hyperemia, ocular pain, and photophobia...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27771043/tracking-the-development-of-agrammatic-aphasia-a-tensor-based-morphometry-study
#14
Jennifer L Whitwell, Joseph R Duffy, Mary M Machulda, Heather M Clark, Edythe A Strand, Matthew L Senjem, Jeffrey L Gunter, Anthony J Spychalla, Ronald C Petersen, Clifford R Jack, Keith A Josephs
Agrammatic aphasia can be observed in neurodegenerative disorders and has been traditionally linked with damage to Broca's area, although there have been disagreements concerning whether damage to Broca's area is necessary or sufficient for the development of agrammatism. We aimed to investigate the neuroanatomical correlates of the emergence of agrammatic aphasia utilizing a unique cohort of patients with primary progressive apraxia of speech (PPAOS) that did not have agrammatism at baseline but developed agrammatic aphasia over time...
September 30, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27768047/eye-tracking-control-to-assess-cognitive-functions-in-patients-with-amyotrophic-lateral-sclerosis
#15
Jürgen Keller, Martin Gorges, Helena E A Aho-Özhan, Ingo Uttner, Erich Schneider, Jan Kassubek, Elmar H Pinkhardt, Albert C Ludolph, Dorothée Lulé
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with pathological involvement of upper and lower motoneurons, subsequently leading to progressive loss of motor and speech abilities. In addition, cognitive functions are impaired in a subset of patients. To evaluate these potential deficits in severely physically impaired ALS patients, eye-tracking is a promising means to conduct cognitive tests. The present article focuses on how eye movements, an indirect means of communication for physically disabled patients, can be utilized to allow for detailed neuropsychological assessment...
October 13, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27761171/shprintzen-goldberg-syndrome-a-rare-disorder
#16
Sankalp Yadav, Gautam Rawal
Shprintzen-Goldberg Syndrome is an extremely infrequent disorder of connective tissue, characterized by craniosynostosis and marfanoid features, also known as Marfanoid Craniosynostosis syndrome. The syndrome was first introduced by Sugarman and Vogel' (1981) however, Shprintzen and Goldberg established this as a separate clinical entity in the year 1982. Since then, approximately sixty such cases have been set down in writing in the medical literature. Herein, we present a short review of literature of this rare connective disorder, in order to create awareness about this condition, as the magnitude of this disorder is not measured properly due to the paucity of literature...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27711939/the-ege-agraphia-test-battery-for-identifying-the-writing-disorders-in-cases-with-mild-cognitive-impairment-and-alzheimer-s-disease
#17
Dilek Evyapan Akkuş, Ayşe Güler
OBJECTIVE: The purpose of this study is to create an agraphia test battery specific to Turkish language, to obtain normative data for the performance and error types of this test and to demonstrate its success in detecting cognitive disorders in mild cognitive impairment (MCI) cases that can't be diagnosed by formal neuropsychological tests due to the fact that writing is a complex function. METHOD: For this purpose, 20 healthy control (HC) subjects, 20 MCI cases and 20 Alzheimer's disease (AD) patients with Clinical Dementia Rating (CDR) of 1 were evaluated with Ege Agraphia Test Battery...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/27701703/language-disorders-in-adolescents-current-needs-and-future-directions
#18
Marilyn A Nippold
Adolescents with developmental language disorders often do not receive the type of intervention that would improve their ability to speak, listen, read, and write effectively. Part of the problem is that many of these young people show no obvious symptoms of a language disorder, yet they struggle on a daily basis to succeed at school-related tasks that require a sophisticated level of language development. This article discusses some of the challenges these students face and makes suggestions for what could be done to address the issues...
November 2016: Seminars in Speech and Language
https://www.readbyqxmd.com/read/27696930/dopamine-drd2-polymorphism-drd2-annk1-taq1a-is-not-a-significant-risk-factor-in-writer-s-cramp
#19
Kirsten E Zeuner, Albert Acewicz, Arne Knutzen, Dirk Dressler, Katja Lohmann, Karsten Witt
Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A polymorphism (rs1800497). This study addresses the question of whether the DRD2/ANKK1-Taq1A polymorphism is a risk factor for writer's cramp. We determined the DRD2/ANKK1-Taq1A polymorphism 34 patients with writer's cramp compared to 67 age matched controls...
October 4, 2016: Journal of Neurogenetics
https://www.readbyqxmd.com/read/27688204/reading-in-dyslexia-across-literacy-development-a-longitudinal-study-of-effective-connectivity
#20
Frøydis Morken, Turid Helland, Kenneth Hugdahl, Karsten Specht
Dyslexia is a literacy disorder affecting the efficient acquisition of reading and writing skills. The disorder is neurobiological in origin. Due to its developmental nature, longitudinal studies of dyslexia are of essence. They are, however, relatively scarce. The present study took a longitudinal approach to cortical connectivity of brain imaging data in reading tasks in children with dyslexia and children with typical reading development. The participants were followed with repeated measurements through Pre-literacy (6 years old), Emergent Literacy (8 years old) and Literacy (12 years old) stages, using Dynamic Causal Modelling (DCM) when analysing functional magnetic resonance imaging (fMRI) data...
September 26, 2016: NeuroImage
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