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https://www.readbyqxmd.com/read/29775078/effects-of-a-parent-implemented-developmental-reciprocity-treatment-program-for-children-with-autism-spectrum-disorder
#1
Grace W Gengoux, Salena Schapp, Sarah Burton, Christina M Ardel, Robin A Libove, Gina Baldi, Kari L Berquist, Jennifer M Phillips, Antonio Y Hardan
Developmental approaches to autism treatment aim to establish strong interpersonal relationships through joint play. These approaches have emerging empirical support; however, there is a need for further research documenting the procedures and demonstrating their effectiveness. This pilot study evaluated changes in parent behavior and child autism symptoms following a 12-week Developmental Reciprocity Treatment parent-training program. A total of 22 children with autism spectrum disorder between 2 and 6 years (mean age = 44...
May 1, 2018: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29770430/nr4a2-haploinsufficiency-is-associated-with-intellectual-disability-and-autism-spectrum-disorder
#2
J Lévy, S Grotto, C Mignot, C Dupont, A Delahaye, B Benzacken, B Keren, D Haye, J Xavier, M Heulin, E Charles, A Verloes, A Maruani, E Pipiras, A-C Tabet
NR4A2, a member of the nuclear receptor superfamily, is involved in modulation of target gene transcription, regulating several developmental processes such as regulation of cellular homeostasis, neuronal development, inflammation and carcinogenesis. 2q24.1 deletions are extremely rare and only one patient with a de novo deletion encompassing only NR4A2 gene was reported so far. We report three additional patients with a de novo deletion encompassing NR4A2: two patients have deletions encompassing only NR4A2 gene and one patient has a deletion including NR4A2 and the first exon of GPD2...
May 16, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29767824/variability-in-verbal-and-nonverbal-communication-in-infants-at-risk-for-autism-spectrum-disorder-predictors-and-outcomes
#3
M Franchini, E Duku, V Armstrong, J Brian, S E Bryson, N Garon, W Roberts, C Roncadin, L Zwaigenbaum, I M Smith
Early communication impairment is among the most-reported first concerns in parents of young children with autism spectrum disorder (ASD). Using a parent-report questionnaire, we derived trajectory groups for early language and gesture acquisition in siblings at high risk for ASD and in children at low risk, during their first 2 years of life. Developmental skills at 6 months were associated with trajectory group membership representing growth in receptive language and gestures. Behavioral symptoms also predicted gesture development...
May 16, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29763417/meta-analyses-of-individual-versus-group-interventions-for-pre-school-children-with-autism-spectrum-disorder-asd
#4
Yoshiyuki Tachibana, Celine Miyazaki, Masashi Mikami, Erika Ota, Rintaro Mori, Yeonhee Hwang, Akiko Terasaka, Eriko Kobayashi, Yoko Kamio
There is little evidence regarding the effects of individual and group intervention for children with autism spectrum disorder (ASD) on important outcomes. We performed meta-analyses using a random effects model to investigate the effectiveness of the individual and group intervention studies and to compare the effectiveness of these two types if possible. The main analysis which excluded studies at a high risk of bias (Analysis I) included 14 randomised controlled trials targeting children with ASD≤6 years of age (594 children)...
2018: PloS One
https://www.readbyqxmd.com/read/29754762/developmental-delay-in-communication-among-toddlers-and-its-relationship-to-caregiving-behavior-among-violence-exposed-posttraumatically-stressed-mothers
#5
R Torrisi, E Arnautovic, V C Pointet Perizzolo, M Vital, A Manini, F Suardi, M Gex-Fabry, S Rusconi Serpa, D S Schechter
OBJECTIVES: This study aimed to understand if maternal interpersonal violence-related posttraumatic stress disorder (IPV-PTSD) is associated with delayed language development among very young children ("toddlers"). METHODS: Data were collected from 61 mothers and toddlers (ages 12-42 months, mean age = 25.6 months SD = 8.70). Child expressive and receptive language development was assessed by the Ages and Stages Questionnaire (ASQ) communication subscale (ASQCS) that measures language acquisition...
May 10, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29754444/peptidome-analysis-reveals-novel-serum-biomarkers-for-children-with-autism-spectrum-disorder-in-china
#6
Juan Yang, Yanni Chen, Xiaofan Xiong, Xiaobo Zhou, Lin Han, Ei Ni, Wenjing Wang, Xiaofei Wang, Lingyu Zhao, Dongdong Shao, Chen Huang
PURPOSE: Autism spectrum disorder (ASD) is a neurological and developmental disorder that begins early in childhood and lasts throughout one's life. Early diagnosis is essential for ASD since early treatment can enable children with ASD to make significant gains in language and social skills, but remains challenging since there are currently no specific biomarkers of ASD. The study aimed to identify serum biomarkers for ASD. EXPERIMENTAL DESIGN: Serum of Han Chinese children with ASD (n = 68) and age-matched healthy controls (n = 80) was analyzed using magnetic bead-based separation combined with mass spectrum...
May 13, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29742572/development-of-human-face-literature-database-using-text-mining-approach-phase-i
#7
Paramjit Kaur, Kewal Krishan, Suresh K Sharma
The face is an important part of the human body by which an individual communicates in the society. Its importance can be highlighted by the fact that a person deprived of face cannot sustain in the living world. The amount of experiments being performed and the number of research papers being published under the domain of human face have surged in the past few decades. Several scientific disciplines, which are conducting research on human face include: Medical Science, Anthropology, Information Technology (Biometrics, Robotics, and Artificial Intelligence, etc...
May 8, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29740364/-developmental-delay-reconsidered-the-critical-role-of-age-dependent-co-variant-development
#8
Yonata Levy
In memory of Annette Karmiloff-Smith . This paper reviews recent neurobiological research reporting structural co-variance and temporal dependencies in age-dependent gene expression, parameters of cortical maturation, long range connectivity and interaction of the biological network with the environment. This research suggests that age by size trajectories of brain structures relate to functional properties more than absolute sizes. In line with these findings, recent behavioral studies of typically developing children whose language development was delayed reported long term consequences of such delays...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29728720/-management-of-developmental-speech-language-disorders-in-children-part-1-diagnosis-and-underlying-comorbid-diseases
#9
R Schönweiler
Compared to other countries, the prevalence of speech-language disorders among children and also the intervention frequency appear to be much higher in Germany. Since otorhinolaryngologists often initiate speech-language interventions, the first part of this review systematically outlines the guideline-conform diagnostic pathway from examination to therapeutic intervention. The process of first developing a suspected diagnosis which justifies speech-language tests is explained. Beyond this, the rational selection of a set of tests from all those available-some of which the otorhinolaryngologist can perform, some of which require referral-is discussed, as is how these results can be used to assess the severity of the disorder...
May 4, 2018: HNO
https://www.readbyqxmd.com/read/29724639/speech-recognition-in-noise-by-children-with-and-without-dyslexia-how-is-it-related-to-reading
#10
Susan Nittrouer, Letitia M Krieg, Joanna H Lowenstein
PURPOSE: Developmental dyslexia is commonly viewed as a phonological deficit that makes it difficult to decode written language. But children with dyslexia typically exhibit other problems, as well, including poor speech recognition in noise. The purpose of this study was to examine whether the speech-in-noise problems of children with dyslexia are related to their reading problems, and if so, if a common underlying factor might explain both. The specific hypothesis examined was that a spectral processing disorder results in these children receiving smeared signals, which could explain both the diminished sensitivity to phonological structure - leading to reading problems - and the speech recognition in noise difficulties...
June 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29713261/transcranial-direct-current-stimulation-tdcs-can-modulate-eeg-complexity-of-children-with-autism-spectrum-disorder
#11
Jiannan Kang, Erjuan Cai, Junxia Han, Zhen Tong, Xin Li, Estate M Sokhadze, Manuel F Casanova, Gaoxiang Ouyang, Xiaoli Li
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder which affects the developmental trajectory in several behavioral domains, including impairments of social communication, cognitive and language abilities. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, and it was used for modulating the brain disorders. In this paper, we enrolled 13 ASD children (11 males and 2 females; mean ± SD age: 6.5 ± 1.7 years) to participate in our trial. Each patient received 10 treatments over the dorsolateral prefrontal cortex (DLPFC) once every 2 days...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29710337/the-role-of-language-in-nonlinguistic-stimuli-comparing-inhibition-in-children-with-language-impairment
#12
Hettie Roebuck, Heidi Sindberg, Susan Ellis Weismer
Purpose: There is conflicting evidence regarding if and how a deficit in executive function may be associated with developmental language impairment (LI). Nonlinguistic stimuli are now frequently used when testing executive function to avoid a language confound. However, it is possible that increased stimulus processing demands for nonlinguistic stimuli may also compound the complexity of the relationship between executive function and LI. The current study examined whether variability across nonlinguistic auditory stimuli might differentially affect inhibition and whether performance differs between children with and without language difficulties...
April 18, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29708487/referral-and-diagnosis-of-developmental-auditory-processing-disorder-in-a-large-united-states-hospital-based-audiology-service
#13
David R Moore, Stephanie L Sieswerda, Maureen M Grainger, Alexandra Bowling, Nicholette Smith, Audrey Perdew, Susan Eichert, Sandra Alston, Lisa W Hilbert, Lynn Summers, Li Lin, Lisa L Hunter
BACKGROUND: Children referred to audiology services with otherwise unexplained academic, listening, attention, language, or other difficulties are often found to be audiometrically normal. Some of these children receive further evaluation for auditory processing disorder (APD), a controversial construct that assumes neural processing problems within the central auditory nervous system. This study focuses on the evaluation of APD and how it relates to diagnosis in one large pediatric audiology facility...
May 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29705533/association-between-enterovirus-infection-and-speech-and-language-impairments-a-nationwide-population-based-study
#14
Tai-Hsin Hung, Vincent Chin-Hung Chen, Yao-Hsu Yang, Ching-Shu Tsai, Mong-Liang Lu, Roger S McIntyre, Yena Lee, Kuo-You Huang
BACKGROUND AND AIMS: Delay and impairment in Speech and language are common developmental problems in younger populations. Hitherto, there has been minimal study of the association between common childhood infections (e.g. enterovirus [EV]) and speech and language. The impetus for evaluating this association is provided by evidence linking inflammation to neurodevelopmental disorders. Herein we sought to determine whether an association exists between EV infection and subsequent diagnoses of speech and language impairments in a nationwide population-based sample in Taiwan...
April 26, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29705112/a-brain-marker-for-developmental-speech-disorders
#15
Angela T Morgan, Merina Su, Sheena Reilly, Gina Conti-Ramsden, Alan Connelly, Frédérique J Liégeois
OBJECTIVE: To characterize the organization of speech- and language-related white matter tracts in children with developmental speech and/or language disorders. STUDY DESIGN: We collected magnetic resonance diffusion-weighted imaging data from 41 children, ages 9-11 years, with developmental speech and/or language disorders, and compared them with 45 typically developing controls with the same age range. We used probabilistic tractography of diffusion-weighted imaging to map language (3 segments of arcuate fasciculus, extreme capsule system) and speech motor (corticobulbar) tracts bilaterally...
April 25, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29699725/trajectories-of-cognitive-development-in-toddlers-with-language-delays
#16
Laura Henry, Cristan Farmer, Stacy S Manwaring, Lauren Swineford, Audrey Thurm
BACKGROUND: Toddlers with early language delays (LD) are at risk for developmental difficulties, including autism spectrum disorder (ASD). However, little is known about early cognitive skill acquisition in this population. AIMS: To explore heterogeneity in cognitive development in toddlers with significant LD (n = 30) or typical development (n = 61), and how this relates to 36-month outcomes (ASD, non-ASD delays, or no delays). METHODS: Growth mixture modeling of nonverbal and verbal mental age (NVMA, VMA) scores from the Mullen Scales of Early Learning was conducted with data from 18, 24 and 36 months...
April 23, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29696050/are-the-norms-of-bayley-screening-test-appropriate-for-persian-language-children
#17
Farin Soleimani, Nadia Azari, Roshanak Vameghi, Firoozeh Sajedi, Soheila Shahshahani, Hossein Karimi, Adis Kraskian, Amin Shahrokhi, Robab Teymouri, Masoud Gharib, Nayereh Mehdipour
Objective: We aimed to assess the distribution of the Bayley screening test by age, and compare developmental risk category distributions between Persian language children and reference norms. Materials & Methods: A representative sample of 417 children, 1 to 42-months-old, by consecutive sampling from health -care centers were enrolled, during 2014 to 2015 in Tehran, Iran. The cognitive, language and motor development of children were evaluated using Bayley screening test...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29691944/developmental-performance-of-5-year-old-bulgarian-children-an-example-of-translational-neuroscience-in-practice
#18
Ralitsa Yordanova, Ivan Ivanov
RATIONALE, AIMS, AND OBJECTIVES: Developmental testing is essential for early recognition of the various developmental impairments. The tools used should be composed of items that are age specific, adapted, and standardized for the population they are applied to. The achievements of neurosciences, medicine, psychology, pedagogy, etc. are applied in the elaboration of a comprehensive examination tool that should screen all major areas of development. The key age of 5 years permits identification of almost all major developmental disabilities leaving time for therapeutic intervention before school entrance...
April 25, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29681085/two-novel-cases-expanding-the-phenotype-of-setd2-related-overgrowth-syndrome
#19
Maartje C van Rij, Iris H I M Hollink, Paulien Anna Terhal, Sarina G Kant, Claudia Ruivenkamp, Arie van Haeringen, J Anneke Kievit, Martine J van Belzen
The SETD2-related overgrowth syndrome is also called "Luscan-Lumish syndrome" (OMIM 616831) with the clinical characteristics of intellectual disability, speech delay, macrocephaly, facial dysmorphism, and autism spectrum disorders. We report on two novel patients a 4.5-year-old boy and a 23-year-old female adolescent with a speech and language developmental delay, autism spectrum disorder and macrocephaly, who were both diagnosed with SETD2-related overgrowth syndrome due to de novo frameshift mutations in the SETD2 gene...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29676529/implicit-learning-seems-to-come-naturally-for-children-with-autism-but-not-for-children-with-specific-language-impairment-evidence-from-behavioral-and-erp-data
#20
Fenny S Zwart, Constance Th W M Vissers, Roy P C Kessels, Joseph H R Maes
Autism spectrum disorder (ASD) and specific language impairment (SLI) are two neurodevelopmental disorders characterized by deficits in verbal and nonverbal communication skills. These skills are thought to develop largely through implicit-or automatic-learning mechanisms. The aim of the current paper was to investigate the role of implicit learning abilities in the atypical development of communication skills in ASD and SLI. In the current study, we investigated Response Times (RTs) and Event Related Potentials (ERPs) during implicit learning on a Serial Reaction Time (SRT) task in a group of typically developing (TD) children (n = 17), a group of autistic children (n = 16), and a group of children with SLI (n = 13)...
April 20, 2018: Autism Research: Official Journal of the International Society for Autism Research
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