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https://www.readbyqxmd.com/read/29774960/alteration-of-nociceptive-integration-in-the-spinal-cord-of-a-rat-model-of-parkinson-s-disease
#1
Keri-Ann Charles, Frédéric Naudet, Rabia Bouali-Benazzouz, Marc Landry, Philippe De Deurwaerdère, Pascal Fossat, Abdelhamid Benazzouz
BACKGROUND: Pain is a major non motor symptom that contributes to impaired quality of life in PD. However, its mechanism is unknown. OBJECTIVES AND METHODS: We sought to identify the pain phenotypes and parallel changes in spinal integration of peripheral stimuli in a rat model of PD induced by lesions of SN dopamine neurons, using behavioral plantar and von Frey tests as well as electrophysiology of the dorsal horn. RESULTS: We show that dopamine depletion by 6-OHDA induced hypersensitivity to mechanical and thermal stimuli...
May 18, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29774624/what-does-it-take-to-stress-a-word-digital-manipulation-of-stress-markers-in-ataxic-dysarthria
#2
Anja Lowit, Tolulope Ijitona, Anja Kuschmann, Stephen Corson, John Soraghan
BACKGROUND: Stress production is important for effective communication, but this skill is frequently impaired in people with motor speech disorders. The literature reports successful treatment of these deficits in this population, thus highlighting the therapeutic potential of this area. However, no specific guidance is currently available to clinicians about whether any of the stress markers are more effective than others, to what degree they have to be manipulated, and whether strategies need to differ according to the underlying symptoms...
May 18, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29774619/different-types-of-multiple-synapse-boutons-in-the-cerebellar-cortex-between-physically-enriched-and-ataxic-mutant-mice
#3
Hyun-Wook Kim, Seunghak Oh, Seung Hwan Lee, Sanghoon Lee, Ji-Eun Na, Kea Joo Lee, Im Joo Rhyu
Experience-dependent synapse remodeling is associated with information storage in the nervous system. Neuronal synapses show alteration in various neurological and cognitive disorders in their structure and function. At the ultrastructural level, parallel fiber boutons contacting multiple spines of Purkinje cells in the cerebellar cortex are commonly observed in physiologically enriched animals as well as pathological ataxic mutants. However, the dendritic origin of those spines on parallel fiber multiple-synapse boutons (MSBs) has been poorly understood...
May 18, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29774500/thalamocortical-dysconnectivity-in-premenstrual-syndrome
#4
Peng Liu, Ying Wei, Hai Liao, Yingying Fan, Ru Li, Nana Feng, Gaoxiong Duan, Demao Deng, Wei Qin
Premenstrual syndrome (PMS) is a menstrual cycle-related disorder. Although the precise pathophysiology is not fully understood, it is increasingly believed that the central nervous system plays a vital role in the development of PMS. The aim of this study is to elucidate specific functional connectivity between the thalamus and cerebral cortex. Resting-state functional magnetic resonance imaging (fMRI) data were obtained from 20 PMS patients and 21 healthy controls (HCs). Seed-based functional connectivity between the thalamus and six cortical regions of interest, including the prefrontal cortex (PFC), posterior parietal cortex, somatosensory cortex, motor cortex/supplementary motor area, temporal and occipital lobe, was adopted to identify specific thalamocortical connectivity in the two groups...
May 17, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29774002/on-the-drive-specificity-of-freudian-drives-for-the-generation-of-seeking-activities-the-importance-of-the-underestimated-imperative-motor-factor
#5
Michael Kirsch, Wolfgang Mertens
Doubters of Freud's theory of drives frequently mentioned that his approach is outdated and therefore cannot be useful for solving current problems in patients with mental disorders. At present, many scientists believe that affects rather than drives are of utmost importance for the emotional life and the theoretical framework of affective neuroscience, developed by Panksepp, strongly underpinned this view. Panksepp evaluated seven so-called command systems and the SEEKING system is therein of central importance...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29773203/validation-of-semiautomatic-scoring-of-rem-sleep-without-atonia-in-patients-with-rbd
#6
D Guttowski, G Mayer, W H Oertel, K Kesper, T Rosenberg
OBJECTIVE/BACKGROUND: To evaluate REM sleep without atonia (RSWA) in REM sleep behavior disorder (RBD) several automatic algorithms have been developed. We aimed to validate our algorithm (Mayer et al., 2008) in order to assess the following: (1). capability of the algorithm to differentiate between RBD, night terror (NT), somnambulism (SW), Restless legs syndrome (RLS), and obstructive sleep apnea (OSA), (2). the cut-off values for short (SMI) and long muscle activity (LMI), (3). which muscles qualify best for differential diagnosis, and (4)...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29772343/brain-stimulation-differentially-modulates-nociception-and-inflammation-in-aversive-and-non-aversive-behavioural-conditions
#7
G S Bassi, A Kanashiro, G J Rodrigues, F Q Cunha, N C Coimbra, L Ulloa
Inflammation and pain are major clinical burdens contributing to multiple disorders and limiting the quality of life of patients. We previously reported that brain electrical stimulation can attenuate joint inflammation in experimental arthritis. Here, we report that non-aversive electrical stimulation of the locus coeruleus (LC), the paraventricular hypothalamic nucleus (PVN) or the ventrolateral column of the periaqueductal grey matter (vlPAG) decreases thermal pain sensitivity, knee inflammation and synovial neutrophilic infiltration in ratswith intra-articular zymosan...
May 14, 2018: Neuroscience
https://www.readbyqxmd.com/read/29771624/virtual-reality-training-to-enhance-behavior-and-cognitive-function-among-children-with-attention-deficit-hyperactivity-disorder-brief-report
#8
Shirley Shema-Shiratzky, Marina Brozgol, Pablo Cornejo-Thumm, Karen Geva-Dayan, Michael Rotstein, Yael Leitner, Jeffrey M Hausdorff, Anat Mirelman
PURPOSE: To examine the feasibility and efficacy of a combined motor-cognitive training using virtual reality to enhance behavior, cognitive function and dual-tasking in children with Attention-Deficit/Hyperactivity Disorder (ADHD). METHODS: Fourteen non-medicated school-aged children with ADHD, received 18 training sessions during 6 weeks. Training included walking on a treadmill while negotiating virtual obstacles. Behavioral symptoms, cognition and gait were tested before and after the training and at 6-weeks follow-up...
May 17, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29771186/cross-modal-plasticity-among-sensory-networks-in-neuromyelitis-optica-spectrum-disorders
#9
Maria Assunta Rocca, Filippo Savoldi, Paola Valsasina, Marta Radaelli, Paolo Preziosa, Giancarlo Comi, Andrea Falini, Massimo Filippi
OBJECTIVE: To explore resting-state (RS) functional connectivity (FC) of the main sensory/motor networks of patients with neuromyelitis optica spectrum disorders (NMOSDs), clinically isolated optic neuritis (ON), and myelitis. METHODS: Clinical evaluation and RS fMRI were obtained from 28 NMOSD, 11 recurrent ON, and 12 recurrent myelitis patients and 30 healthy controls. Between-group RS FC comparisons and correlations with motor performance were assessed (SPM12) on the main sensory/motor RS networks (RSNs) identified by independent component analysis...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29770609/whole-exome-sequencing-for-variant-discovery-in-blepharospasm
#10
Jun Tian, Satya R Vemula, Jianfeng Xiao, Enza Maria Valente, Giovanni Defazio, Simona Petrucci, Angelo Fabio Gigante, Monika Rudzińska-Bar, Zbigniew K Wszolek, Kathleen D Kennelly, Ryan J Uitti, Jay A van Gerpen, Peter Hedera, Elizabeth J Trimble, Mark S LeDoux
BACKGROUND: Blepharospasm (BSP) is a type of focal dystonia characterized by involuntary orbicularis oculi spasms that are usually bilateral, synchronous, and symmetrical. Despite strong evidence for genetic contributions to BSP, progress in the field has been constrained by small cohorts, incomplete penetrance, and late age of onset. Although several genetic etiologies for dystonia have been identified through whole-exome sequencing (WES), none of these are characteristically associated with BSP as a singular or predominant manifestation...
May 16, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29770442/current-concepts-in-the-neuropathogenesis-of-mucolipidosis-type-iv
#11
REVIEW
Lauren C Boudewyn, Steven U Walkley
Mucolipidosis type IV (MLIV) is an autosomal recessive, lysosomal storage disorder causing progressively severe intellectual disability, motor and speech deficits, retinal degeneration often culminating in blindness, and systemic disease causing a shortened lifespan. MLIV results from mutations in the gene MCOLN1 encoding the transient receptor potential channel mucolipin-1. It is an ultra-rare disease and is currently known to affect just over 100 diagnosed individuals. The last decade has provided a wealth of research focused on understanding the role of the enigmatic mucolipin-1 protein in cell and brain function and how its absence causes disease...
May 16, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29770363/the-multifaceted-clinical-presentation-of-vcp-proteinopathy-in-a-greek-family
#12
George K Papadimas, George P Paraskevas, Thomas Zambelis, Chrisostomos Karagiaouris, Mara Bourbouli, Anastasia Bougea, Maggie C Walter, Nicolas U Schumacher, Sabine Krause, Elisabeth Kapaki
VCP-proteinopathy is a multisystem neurodegenerative disorder caused by mutations in valosin containing protein. Here, we report the first Greek case of VCP-proteinopathy in a 62 year old patient with a slowly progressing muscular weakness since his mid-40s and a severe deterioration during the last year. He also manifested dementia with prominent neuropsychiatric symptoms, including aggression, apathy, palilalia and obsessions. Brain MRI revealed frontal atrophy, while muscle MRI showed diffuse muscle atrophy...
December 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29770150/effect-of-cathodal-transcranial-direct-current-stimulation-on-a-child-with-involuntary-movement-after-hypoxic-encephalopathy
#13
Mayumi Nagai, Naofumi Tanaka, Yutaka Oouchida, Shin-Ichi Izumi
The aim of the study was to investigate the effect of cathodal transcranial direct current stimulation to the supplementary motor area to inhibit involuntary movements of a child. An 8-year-old boy who developed hypoxic encephalopathy after asphyxia at the age of 2 had difficulty in remaining standing without support because of involuntary movements. He was instructed to remain standing with his plastic ankle-foot orthosis for 10 s at three time points by leaning forward with his forearms on a desk. He received cathodal or sham transcranial direct current stimulation to the supplementary motor area at 1 mA for 10 min...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29770146/effects-of-20-hz-repetitive-transcranial-magnetic-stimulation-on-disorders-of-consciousness-a-resting-state-electroencephalography-study
#14
Fangping He, Min Wu, Fanxia Meng, Yangfan Hu, Jian Gao, Zhongqin Chen, Wangxiao Bao, Kehong Liu, Benyan Luo, Gang Pan
Repetitive transcranial magnetic stimulation (rTMS) has been proposed as an experimental approach for the treatment of disorders of consciousness (DOC). To date, there has been little research into the use of rTMS in DOC and the therapeutic effects have been variously documented. This study aimed to examine the effects of 20 Hz rTMS on the electroencephalography (EEG) reactivity and clinical response in patients with DOC and to explore the neuromodulatory effects of high-frequency rTMS. In this randomized, sham-controlled, crossover study, real or sham 20 Hz rTMS was applied to the left primary motor cortex (M1) of patients with DOC for 5 consecutive days...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29770123/what-if-low-back-pain-is-the-most-prevalent-parkinsonism-in-the-world
#15
Jesse V Jacobs, Sharon M Henry, Fay B Horak
Low back pain (LBP) has a point prevalence of nearly 10% and ranks highest in global disease burden for years lived with disability; Parkinson's disease (PD) ranks in the top 100 most disabling health conditions for years lost and years lived with disability (1). Recent evidence suggests that people with chronic, recurrent LBP exhibit many postural impairments reminiscent of a neurological postural disorder such as PD. We compare and contrast postural impairments associated with LBP and PD in order to inform treatment strategies for both conditions...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29769744/nadph-ameliorates-mptp-induced-dopaminergic-neurodegeneration-through-inhibiting-p38mapk-activation
#16
Jing-Si Zhou, Zhou Zhu, Feng Wu, Ying Zhou, Rui Sheng, Jun-Chao Wu, Zheng-Hong Qin
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). Although the pathogenic mechanism underlying PD remains largely unknown, decreased nigral glutathione (GSH) in postmortem brains of PD patients supports the presence of oxidative stress in PD. We found that Nicotinamide adenine dinucleotide phosphate (NADPH), which is important for maintaining the level of GSH, protected dopaminergic (DA) neurons from neurotoxicity of MPTP/MPP+ ...
May 16, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29769594/touchscreen-typing-pattern-analysis-for-detecting-fine-motor-skills-decline-in-early-stage-parkinson-s-disease
#17
Dimitrios Iakovakis, Stelios Hadjidimitriou, Vasileios Charisis, Sevasti Bostantzopoulou, Zoe Katsarou, Leontios J Hadjileontiadis
Parkinson's disease (PD) is a degenerative movement disorder causing progressive disability that severely affects patients' quality of life. While early treatment can produce significant benefits for patients, the mildness of many early signs combined with the lack of accessible high-frequency monitoring tools may delay clinical diagnosis. To meet this need, user interaction data from consumer technologies have recently been exploited towards unsupervised screening for PD symptoms in daily life. Similarly, this work proposes a method for detecting fine motor skills decline in early PD patients via analysis of patterns emerging from finger interaction with touchscreen smartphones during natural typing...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769252/frequency-of-non-motor-symptoms-in-parkinson-s-disease-presenting-to-tertiary-care-centre-in-pakistan-an-observational-cross-sectional-study
#18
Shahid Mukhtar, Rashid Imran, Mohsin Zaheer, Huma Tariq
OBJECTIVE: To determine the frequency of non-motor symptoms (NMS) in patients of Parkinson's disease (PD) presenting to a movement disorder clinic at a tertiary care centre in Pakistan, and how frequency of NMS is different in male and female patients. STUDY DESIGN: Observational, cross-sectional study. SETTING: Tertiary care centre. PARTICIPANTS: Out of 102 patients, 85 were included. Inclusion criteria were patients with PD diagnosed according to the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria, age ≥18 years, able to give consent and have no difficulty in answering questions...
May 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29768288/caffeine-sodium-benzoate-for-electroconvulsive-therapy-augmentation
#19
Kevin M Bozymski, Teresa G Potter, Vasu Venkatachalam, Ananda K Pandurangi, Ericka L Crouse
OBJECTIVES: Because of an ongoing manufacturer shortage of injectable caffeine sodium benzoate (CSB), patients at our health system were given CSB compounded in-house to increase seizure response during electroconvulsive therapy (ECT). Therefore, we aimed to evaluate its effectiveness and safety as an ECT augmentation agent. METHODS: Medical records of patients who received compounded CSB at Virginia Commonwealth University Health System were reviewed to identify adults receiving it as part of an index ECT treatment course between June 2012 and December 2016...
May 15, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29767802/sitting-together-and-reaching-to-play-start-play-protocol-for-a-multisite-randomized-controlled-efficacy-trial-on-intervention-for-infants-with-neuromotor-disorders
#20
Regina T Harbourne, Stacey C Dusing, Michele A Lobo, Sarah Westcott-McCoy, James Bovaird, Susan Sheridan, James C Galloway, Hui-Ju Chang, Lin-Ya Hsu, Natalie Koziol, Emily C Marcinowski, Iryna Babik
Background: There is limited research examining the efficacy of early physical therapy on infants with neuromotor dysfunction. In addition, most early motor interventions have not been directly linked to learning, despite the clear association between motor activity and cognition during infancy. Objective: The aim of this project is to evaluate the efficacy of Sitting Together And Reaching To Play (START-Play), an intervention designed to target sitting, reaching, and motor-based problem solving to advance global development in infants with motor delays or neuromotor dysfunction...
June 1, 2018: Physical Therapy
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