Qinqin Zhao, Savannah Bertolli, Young-Jun Park, Yongjun Tan, Kevin J Cutler, Pooja Srinivas, Kyle L Asfahl, Citlali Fonesca-García, Larry A Gallagher, Yaqiao Li, Yaxi Wang, Devin Coleman-Derr, Frank DiMaio, Dapeng Zhang, S Brook Peterson, David Veesler, Joseph D Mougous
Streptomyces are a genus of ubiquitous soil bacteria from which the majority of clinically utilized antibiotics derive1 . The production of these antibacterial molecules reflects the relentless competition Streptomyces engage in with other bacteria, including other Streptomyces species1,2 . Here we show that in addition to small-molecule antibiotics, Streptomyces produce and secrete antibacterial protein complexes that feature a large, degenerate repeat-containing polymorphic toxin protein. A cryo-electron microscopy structure of these particles reveals an extended stalk topped by a ringed crown comprising the toxin repeats scaffolding five lectin-tipped spokes, which led us to name them umbrella particles...
April 17, 2024: Nature