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carbetocin and depression

Xiaolu Meng, Fang Shen, Chunlu Li, Yonghui Li, Xuewei Wang
Tree shrews, a species phylogenetically close to primates, are regarded as a suitable and naturalistic animal model for depression studies. However, psychological symptoms that are essential for depression diagnosis and treatment, such as helplessness and social withdrawal, have not been studied in this model. Therefore, in this study, we first investigated learned helplessness, social interaction and sucrose preference induced by two chronic stress paradigms: uncontrollable foot shocks (1-week foot shocks) and multiple unpredictable stimuli (1-week foot shocks and 3-week unpredictable stressors) in tree shrews...
June 2016: Pharmacology, Biochemistry, and Behavior
Jérôme Mairesse, Eleonora Gatta, Marie-Line Reynaert, Jordan Marrocco, Sara Morley-Fletcher, Marion Soichot, Lucie Deruyter, Gilles Van Camp, Hammou Bouwalerh, Francesca Fagioli, Anna Pittaluga, Delphine Allorge, Ferdinando Nicoletti, Stefania Maccari
Oxytocin receptors are known to modulate synaptic transmission and network activity in the hippocampus, but their precise function has been only partially elucidated. Here, we have found that activation of presynaptic oxytocin receptor with the potent agonist, carbetocin, enhanced depolarization-evoked glutamate release in the ventral hippocampus with no effect on GABA release. This evidence paved the way for examining the effect of carbetocin treatment in "prenatally restraint stressed" (PRS) rats, i.e., the offspring of dams exposed to repeated episodes of restraint stress during pregnancy...
December 2015: Psychoneuroendocrinology
Panos Zanos, Polymnia Georgiou, Sherie R Wright, Susanna M Hourani, Ian Kitchen, Raphaëlle Winsky-Sommerer, Alexis Bailey
The main challenge in treating opioid addicts is to maintain abstinence due to the affective consequences associated with withdrawal which may trigger relapse. Emerging evidence suggests a role of the neurohypophysial peptide oxytocin (OT) in the modulation of mood disorders as well as drug addiction. However, its involvement in the emotional consequences of drug abstinence remains unclear. We investigated the effect of 7-day opioid abstinence on the oxytocinergic system and assessed the effect of the OT analogue carbetocin (CBT) on the emotional consequences of opioid abstinence, as well as relapse...
March 2014: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
J H Broadbear, D Kabel, L Tracy, P Mak
The interconnections between the serotonin and oxytocin pathways in the brain suggest that changes in oxytocin levels - arising from natural or drug-induced stimuli - lead to measureable changes in mood. In this paper, we review our findings in the context of what is known about the roles of oxytocin and vasopressin in the expression of a range of behaviours. In our first set of studies we investigated whether stimulation of oxytocin and vasopressin receptors, via central or systemic drug administration, would produce behavioural changes indicative of anti-depressant or anxiolytic activity...
April 2014: Pharmacology, Biochemistry, and Behavior
Stella Chaviaras, Plato Mak, David Ralph, Lalitha Krishnan, Jillian H Broadbear
RATIONALE: The distribution of oxytocin receptors in limbic regions, as well as evidence that exogenous oxytocin modulates affect and fear processing, suggests that this neuropeptide may have a role to play in the treatment of mood disorders. OBJECTIVES: This study compared the effects of acute treatment with the oxytocin receptor agonist, carbetocin with the tricyclic antidepressant, imipramine, using male Sprague-Dawley rats. METHODS: Intracerebroventricular (i...
May 2010: Psychopharmacology
V Klenerova, I Krejci, P Sida, Z Hlinak, S Hynie
Oxytocin (OXY) has been shown to attenuate some of the physiological and behavioral alterations appearing in stressed rats. Carbetocin (CBT), an oxytocin analog [deamino-1-monocarba-(2-O-methyltyrosine)-oxytocin], was designed to exert prolonged action. In the present study we investigated the impact of these peptides on the behavioral changes in rats exposed repeatedly to restraint stressors. Wistar male rats were exposed to restraint for 1 hour; saline or drugs were administered intraperitoneally immediately after stress termination...
June 2009: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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