Kazuya Toriumi, Kyoka Iino, Azuna Ozawa, Mitsuhiro Miyashita, Syudo Yamasaki, Kazuhiro Suzuki, Hikari Sugawa, Koichi Tabata, Satoshi Yamaguchi, Satoshi Usami, Masanari Itokawa, Atsushi Nishida, Ryoji Nagai, Hidenori Kamiguchi, Makoto Arai
Pentosidine (PEN) is an advanced glycation end-product (AGEs), where a fluorescent cross-link is formed between lysine and arginine residues in proteins. Accumulation of PEN is associated with aging and various diseases. We previously reported that a subpopulation of patients with schizophrenia showed PEN accumulation in the blood, having severe clinical features. PEN is thought to be produced from glucose, fructose, pentoses, or ascorbate. However, patients with schizophrenia with high PEN levels present no elevation of these precursors of PEN in their blood...
November 2023: Redox Biology