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https://www.readbyqxmd.com/read/29031239/probiotic-intervention-influences-the-salivary-levels-of-matrix-metalloproteinase-mmp-9-and-tissue-inhibitor-of-metalloproteinases-timp-1-in-healthy-adults
#1
Heli Jäsberg, Taina Tervahartiala, Timo Sorsa, Eva Söderling, Anna Haukioja
OBJECTIVE: To study the effect of orally administered Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus rhamnosus GG on the salivary levels of Matrix Metalloproteinases (MMP)-8, MMP-9 and of Tissue Inhibitor of Metalloproteinases (TIMP)-1 in healthy adults. Furthermore, the correlations between MMP-8, MMP-9 and TIMP-1 and plaque and gingival indices, salivary mutans streptococci and lactobacilli counts, and stimulated saliva secretion rate were analysed. DESIGN: The salivary samples originated from a randomized controlled trial where healthy student volunteers consumed probiotic or placebo lozenges twice a day for four weeks...
October 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29029258/acupuncture-improves-peri-menopausal-insomnia-a-randomized-controlled-trial
#2
Fu Cong, Zhao Na, Liu Zhen, Yuan Lu-Hua, Xie Chen, Yang Wen-Jia, Yu Xin-Tong, Yu Huan, Chen Yun-Fei
Study Objective: To evaluate the short-term efficacy of acupuncture for the treatment of peri-menopausal insomnia (PMI). Methods: Design: A randomized, participant-blind, placebo-controlled trial consisted of the acupuncture group (n=38) and placebo-acupuncture group (n=38). Setting: A tertiary teaching and general hospital. Participants: 76 peri-menopausal women with insomnia disorder based on the International Classification of Sleep Disorders, third Edition. Interventions: A 10-session of acupuncture at bilateral Shenshu (BL 23) and Ganshu (BL 18) with unilateral Qimen (LR 14) and Jingmen (GB 25) or Streitberger needles at the same acupoints was performed for over 3 weeks...
September 22, 2017: Sleep
https://www.readbyqxmd.com/read/29029049/intraoperative-naloxone-reduces-remifentanil-induced-postoperative-hyperalgesia-but-not-pain-a-randomized-controlled-trial
#3
C-H Koo, S Yoon, B-R Kim, Y J Cho, T K Kim, Y Jeon, J-H Seo
Background: Intraoperative use of a high-dose remifentanil may induce postoperative hyperalgesia. Low-dose naloxone can selectively reverse some adverse effects of opioids without compromising analgesia. We thus hypothesized that the intraoperative use of a high-dose remifentanil combined with a low-dose naloxone infusion reduces postoperative hyperalgesia compared with the use of remifentanil alone. Methods: Patients undergoing elective thyroid surgery were randomly assigned into one of three groups, depending on the intraoperative effect-site concentration of remifentanil, with or without a continuous infusion of naloxone: 4 ng ml-1 remifentanil with 0...
October 3, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29029015/an-experimental-study-comparing-the-respiratory-effects-of-tapentadol-and-oxycodone-in-healthy-volunteers
#4
R van der Schrier, K Jonkman, M van Velzen, E Olofsen, A M Drewes, A Dahan, M Niesters
Background: There is a clinical need for potent opioids that produce little or no respiratory depression. In the current study we compared the respiratory effects of tapentadol, a mu-opioid receptor agonist and noradrenaline reuptake inhibitor, and oxycodone, a selective mu-opioid receptor agonist. We hypothesize that tapentadol 100 mg has a lesser effect on the control of breathing than oxycodone 20 mg. Methods: Fifteen healthy volunteers were randomized to receive oral tapentadol (100 and 150 mg), oxycodone 20 mg or placebo immediate release tablets in a crossover double-blind randomized design...
October 4, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29028981/tofacitinib-in-patients-with-ulcerative-colitis-health-related-quality-of-life-in-phase%C3%A2-3-randomized-controlled-induction-and-maintenance-studies
#5
Julian Panés, Séverine Vermeire, James O Lindsay, Bruce E Sands, Chinyu Su, Gary Friedman, Haiying Zhang, Aaron Yarlas, Martha Bayliss, Stephen Maher, Joseph C Cappelleri, Andrew G Bushmakin, David T Rubin
Background and Aims: Tofacitinib is an oral, small molecule JAK inhibitor that is being investigated for UC. We evaluated healthrelated quality of life [HRQoL] in tofacitinib UC Phase 3 studies. Methods: Patients ≥18 years old in OCTAVE Induction 1 [N=598] and 2 [N=541] with moderately to severely active UC were randomized [1:4] to placebo or tofacitinib 10mg twice daily [BID] for 8 weeks. Subsequently, OCTAVE Sustain re-randomized [1:1:1] clinical responders [N=593] from induction studies to placebo, tofacitinib 5 or 10mg BID for 52 weeks...
September 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29028980/influenza-among-young-children-in-bangladesh-clinical-characteristics-and-outcomes-from-a-randomized-clinical-trial
#6
Elizabeth Rotrosen, K Zaman, Jodi Feser, Justin R Ortiz, Doli Goswami, Amina Tahia Sharmeen, Mustafizur Rahman, Kristen D C Lewis, Md Ziaur Rahman, Burc Barin, W Abdullah Brooks, Kathleen M Neuzil
Background: Influenza causes substantial morbidity in children worldwide, although influenza vaccine is seldom used in low-resource settings. More information on the clinical presentation of influenza and the efficacy of vaccine is needed to inform policy. Methods: In 2013 we conducted a randomized, placebo-controlled clinical trial of live attenuated influenza vaccine (LAIV) in children aged 24-59 months in Bangladesh (N = 1761). If participants met prespecified specimen collection criteria, we collected nasopharyngeal washes for testing by singleplex reverse-transcription polymerase chain reaction (RT-PCR) for laboratory-confirmed influenza virus infection (LCI)...
October 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028762/intermittent-versus-continuous-and-intermittent-medications-for-pain-and-sedation-after-pediatric-cardiothoracic-surgery-a-randomized-controlled-trial
#7
Jamie S Penk, Cheryl A Lefaiver, Colleen M Brady, Christine M Steffensen, Kimberly Wittmayer
OBJECTIVES: Compare continuous infusions of morphine and midazolam in addition to intermittent doses with an intermittent only strategy for pain and sedation after pediatric cardiac surgery. DESIGN: Randomized controlled trial. SETTING: Advocate Children's Hospital, Oak Lawn, IL. PATIENTS: Sixty patients 3 months to 4 years old with early extubation after pediatric cardiac surgery. INTERVENTIONS: Patients received a continuous infusion of morphine and midazolam or placebo for 24 hours...
October 12, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29028742/intraoperative-esmolol-as-an-adjunct-for-perioperative-opioid-and-postoperative-pain-reduction-a-systematic-review-meta-analysis-and-meta-regression
#8
Amanda M Gelineau, Michael R King, Karim S Ladha, Sara M Burns, Timothy Houle, T Anthony Anderson
BACKGROUND: Esmolol is an ultrashort β-1 receptor antagonist. Recent studies suggest a role for esmolol in pain response modulation. The authors performed a meta-analysis to determine if the intraoperative use of esmolol reduces opioid consumption or pain scores. METHODS: PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, pubget, and Google Scholar were searched. Studies were included if they were randomized, placebo- or opioid-controlled trials written in English, and performed on patients 18 years of age or older...
October 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29028590/efficacy-and-tolerability-of-lisdexamfetamine-as-an-antidepressant-augmentation-strategy-a-meta-analysis-of-randomized-controlled-trials
#9
Peter Giacobbe, Uros Rakita, Raymond Lam, Roumen Milev, Sidney H Kennedy, Roger S McIntyre
BACKGROUND: Psychostimulants have been used in the treatment of depression, with mixed results. This meta-analysis examines the efficacy and tolerability of the stimulant Lisdexamfetamine (LDX) as an add-on strategy in those with MDD who have failed to respond to an antidepressant. METHOD: Randomized control trials were identified and extracted from Pubmed; Web of Science; PsychINFO; and Cochrane Library. The efficacy of LDX was evaluated using Hedges' g and Odds Ratio, whereas Risk Difference was used to assess the safety and tolerability of LDX...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29028556/buspirone-maintenance-does-not-alter-the-reinforcing-subjective-and-cardiovascular-effects-of-intranasal-methamphetamine
#10
Anna R Reynolds, Justin C Strickland, William W Stoops, Joshua A Lile, Craig R Rush
BACKGROUND: Medications development efforts for methamphetamine-use disorder have targeted central monoamines because these systems are directly involved in the effects of methamphetamine. Buspirone is a dopamine autoreceptor and D3 receptor antagonist and partial agonist at serotonin 1A receptors, making it a logical candidate medication for methamphetamine-use disorder. Buspirone effects on abuse-related behaviors of methamphetamine have been mixed in clinical and preclinical studies...
September 22, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29028436/pain-management-after-hip-arthroscopy-systematic-review-of-randomized-controlled-trials-and-cohort-studies
#11
Jason J Shin, Chris L McCrum, Craig S Mauro, Dharmesh Vyas
BACKGROUND: Hip arthroscopy is often associated with significant postoperative pain and opioid-associated side effects. Effective pain management after hip arthroscopy improves patient recovery and satisfaction and decreases opioid-related complications. PURPOSE: To collect, examine, and provide a comprehensive review of the available evidence from randomized controlled trials and comparative studies on pain control after hip arthroscopy. STUDY DESIGN: Systematic review...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29028079/potency-on-lowering-serum-uric-acid-in-gout-patients-a-pooled-analysis-of-registrative-studies-comparing-febuxostat-vs-allopurinol
#12
M Cutolo, M A Cimmino, F Perez-Ruiz
OBJECTIVE: Hyperuricemia leading to urate crystal formation in tissues represents the pathophysiological mechanism of gout. Guidelines recommend a therapeutic target of serum urate concentration (sUA) <6 mg/dL, or even lower (≤5 mg/dL) in patients with large deposits. We conducted an analysis with the aim to achieve additional insights into the urate-lowering efficacy of two xanthine oxidase inhibitors, allopurinol and febuxostat. PATIENTS AND METHODS: This was a pooled analysis of phase III trials on allopurinol and febuxostat, including 4101 patients with gout and hyperuricemia...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027817/oral-supplementation-of-parturient-mothers-with-vitamin-d-and-its-effect-on-25ohd-status-of-exclusively-breastfed-infants-at-6-months-of-age-a-double-blind-randomized-placebo-controlled-trial
#13
Prasanna Naik, M M A Faridi, Prerna Batra, S V Madhu
BACKGROUND: Exclusively breastfed infants are at increased risk of vitamin D deficiency and many lactating mothers have been found deficient in 25OHD stores. OBJECTIVE: To compare serum vitamin D levels in exclusively breastfed infants at 6 months of age with or without oral supplementation of 600,000 IU of vitamin D3 to mothers in early postpartum period. METHODS: Exclusively breastfeeding term parturient mothers were randomized 24-48 hours following delivery to receive either 600,000 IU of vitamin D3 (Cholecalciferol) over 10 days in a dose of 60,000 IU/day or placebo...
October 13, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29027815/l-carnosine-as-an-adjunctive-therapy-to-risperidone-in-children-with-autistic-disorder-a-randomized-double-blind-placebo-controlled-trial
#14
Reihaneh Hajizadeh-Zaker, Alireza Ghajar, Bita Mesgarpour, Mohsen Afarideh, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
OBJECTIVES: This study aimed at investigating the efficacy and tolerability of l-carnosine as an add-on to risperidone in the management of children with autism. METHODS: This was a 10-week, randomized, double-blind, placebo-controlled study. Seventy drug-free children aged 4-12 years old with a diagnosis of autism spectrum disorder (ASD), according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition. (DSM-5) who had an Aberrant Behavior Checklist-Community (ABC-C) scale irritability subscale score of ≥12, entered the study...
October 13, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29027242/optimal-dose-and-duration-of-amoxicillin-plus-metronidazole-as-an-adjunct-to-non-surgical-periodontal-therapy-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#15
REVIEW
Kelly McGowan, Troy McGowan, Saso Ivanovski
AIM: This systematic review aimed to determine the optimum dose and duration of amoxicillin-plus-metronidazole prescribed as an adjunct to non-surgical treatment of periodontitis. METHODS: Electronic searching identified 376 records, of which 18 were eligible blinded, randomized placebo-controlled trials. The primary outcomes assessed were periodontal pocket depth and clinical attachment level at 3-months, and secondary outcomes were adverse events and compliance...
October 13, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29027116/effect-of-intracoronary-and-intravenous-melatonin-on-myocardial-salvage-index-in-patients-with-st-elevation-myocardial-infarction-a-randomized-placebo-controlled-trial
#16
Sarah Ekeloef, Natalie Halladin, Siv Fonnes, Svend Eggert Jensen, Tomas Zaremba, Jacob Rosenberg, Grete Jonsson, Jens Aarøe, Lærke Smidt Gasbjerg, Mette Marie Rosenkilde, Ismail Gögenur
Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55...
October 12, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29026838/tumor-necrosis-factor-alpha-antibodies-in-fistulizing-crohn-s-disease-an-updated-systematic-review-and-meta-analysis
#17
REVIEW
Pardis Zaboli, Mohammad Abdollahi, Shilan Mozaffari, Shekoufeh Nikfar
Medical treatment for fistulizing Crohn's disease (FCD) is changing rapidly over the time by the introduction of novel therapeutic medicines, while no global consensus is available. This study aims to accomplish a systematic review and meta-analysis on the efficacy of tumor necrosis factor-alpha antibodies (anti-TNF-α antibodies) versus placebo in FCD. A systematic review of published literature was carried out till December 2016, and a meta-analysis of identified studies was done. Data have been explored from PubMed, Scopus, Cochrane Library Database, and Web of Science...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29026810/the-role-of-local-bupivacaine-irrigation-in-postoperative-pain-control-after-augmentation-mammoplasty-a-systematic-review-and-meta-analysis
#18
Shan Shan Qiu, Marta Roque, Yi-Chieh Chen
BACKGROUND: The objective of this study is to analyze the efficacy of local bupivacaine irrigation after augmentation mammoplasty for the control of postoperative pain. METHODS: A systematic review and meta-analysis was conducted including all randomized controlled trials (RCTs) that compared the irrigation of bupivacaine (±ketorolac) versus normal saline or no irrigation for pain control after breast augmentation. The primary outcome was postoperative pain measured by visual analog scale...
February 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29026804/the-effect-of-cardamom-supplementation-on-serum-lipids-glycemic-indices-and-blood-pressure-in-overweight-and-obese-pre-diabetic-women-a-randomized-controlled-trial
#19
Yaghooblou Fatemeh, Fereydoun Siassi, Abbas Rahimi, Fariba Koohdani, Farideh Doostan, Mostafa Qorbani, Gity Sotoudeh
BACKGROUND: Spice consumption helps the treatment of diseases due to their antioxidant and anti-inflammatory contents. Cardamom is one of this spices; therefore, this study is designed to determine the effect of cardamom supplementation on serum lipids, glycemic indices, and blood pressure in pre-diabetic women. METHODS: Eighty overweight or obese pre-diabetic women were randomly allocated to two groups. The intervention group received 3 g of green cardamom and the placebo group received 3 g of rusk powder for 2 months...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/29026604/transglucosidase-improves-the-bowel-movements-in-type-2-diabetes-mellitus-patients-a-preliminary-randomized-double-blind-placebo-controlled-study
#20
Akihiro Shimozato, Makoto Sasaki, Naotaka Ogasawara, Yasushi Funaki, Masahide Ebi, Chiho Goto, Satoshi Koikeda, Takashi Joh, Kunio Kasugai
BACKGROUND: Recent studies have highlighted the relationship between gut microbiota and bowel movements. OBJECTIVE: We aimed to evaluate transglucosidase treatment efficacy for bowel movements in patients with type 2 diabetes mellitus and to clarify the relationship between bowel movements, dietary habits, gut microbiota and fecal short-chain fatty acids. METHODS: In this randomized double-blind, placebo-controlled study, 66 patients received placebo or transglucosidase (300 or 900 mg/day) orally, for 12 weeks...
October 2017: United European Gastroenterology Journal
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