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https://www.readbyqxmd.com/read/29241082/the-effect-of-n-acetylcysteine-and-working-memory-training-on-cocaine-use-craving-and-inhibition-in-regular-cocaine-users-correspondence-of-lab-assessments-and-ecological-momentary-assessment
#1
Mieke H J Schulte, Reinout W Wiers, Wouter J Boendermaker, Anna E Goudriaan, Wim van den Brink, Denise S van Deursen, Malte Friese, Emily Brede, Andrew J Waters
INTRODUCTION: Effective treatment for cocaine use disorder should dampen hypersensitive cue-induced motivational processes and/or strengthen executive control. Using a randomized, double-blind, placebo-controlled intervention, the primary aim of this study was to investigate the effect of N-Acetylcysteine (NAC) and working memory (WM)-training to reduce cocaine use and craving and to improve inhibition assessed in the laboratory and during Ecological Momentary Assessment (EMA). The second aim was to examine correspondence between laboratory and EMA data...
December 11, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29240976/clopidogrel-plus-aspirin-versus-aspirin-alone-for-preventing-cardiovascular-events
#2
REVIEW
Alessandro Squizzato, Marta Bellesini, Andrea Takeda, Saskia Middeldorp, Marco Paolo Donadini
BACKGROUND: Aspirin is the prophylactic antiplatelet drug of choice for people with cardiovascular disease. Adding a second antiplatelet drug to aspirin may produce additional benefit for people at high risk and people with established cardiovascular disease. This is an update to a previously published review from 2011. OBJECTIVES: To review the benefit and harm of adding clopidogrel to aspirin therapy for preventing cardiovascular events in people who have coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease, or were at high risk of atherothrombotic disease, but did not have a coronary stent...
December 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29240854/upregulation-of-extracellular-matrix-genes-corroborates-clinical-efcacy-of-human-fibroblast-derived-growth-factors-in-skin-rejuvenation
#3
Kuniko Kadoya, Elizabeth T Makino, Lily I Jiang, Michael Bachelor, Robin Chung, Priscilla Tan, Tsing Cheng, Gail K Naughton, Rahul C Mehta
<p>Skin care products may use various active ingredients to support skin rejuvenation including growth factors and other molecules that help to regenerate extracellular matrix (ECM) and promote skin repair. The biological effect of skin care products with a strong anti-aging claim was assessed in gene expression analyses using an in vitro human skin model. Application of products containing human fbroblast-derived growth factors resulted in signifcant upregulation of genes encoding ECM components including collagens and elas-tin...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240641/low-dose-insulin-as-an-anti-scarring-therapy-in-breast-surgery-a-randomised-controlled-trial
#4
Marc-James Hallam, Elizabeth Pitt, Alexis Thomas, Charles Nduka
BACKGROUND: The role of insulin in expediting wound healing is firmly established within the context of major trauma and burns however only limited clinical evidence exists as to its effects upon scar formation. This study aims to build upon previous laboratory work to examine the potential anti-scarring properties of insulin in a clinical environment. METHODS: 91 patients undergoing bilateral aesthetic breast surgeries were recruited to receive low-dose insulin and placebo injections to the medial 3cm of their sub-mammary incisions within the context of a randomised, intra-patient, placebo controlled trial and scar quality was assessed at 3, 6, and 12-month reviews using the Manchester Scar Scale...
December 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29240563/impact-of-methylprednisolone-on-postoperative-quality-of-recovery-and-delirium-in-the-steroids-in-cardiac-surgery-trial-a-randomized-double-blind-placebo-controlled-substudy-erratum
#5
https://www.readbyqxmd.com/read/29239947/treatment-of-chronic-pain-with-various-buprenorphine-formulations-a-systematic-review-of-clinical-studies
#6
Rohit Aiyer, Amitabh Gulati, Semih Gungor, Anuj Bhatia, Neel Mehta
Clinical studies demonstrate that buprenorphine is a pharmacologic agent that can be used for the treatment of various types of painful conditions. This study investigated the efficacy of 5 different types of buprenorphine formulations in the chronic pain population. The literature was reviewed on PubMed/MEDLINE, EMBASE, Cochrane Database, clinicaltrials.gov, and PROSPERO that dated from inception until June 30, 2017. Using the population, intervention, comparator, and outcomes method, 25 randomized controlled trials were reviewed involving 5 buprenorphine formulations in patients with chronic pain: intravenous buprenorphine, sublingual buprenorphine, sublingual buprenorphine/naloxone, buccal buprenorphine, and transdermal buprenorphine, with comparators consisting of opioid analgesics or placebo...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29239890/omega-3-decreases-interleukin-6-levels-in-hiv-and-hhv-8-co-infected-patients-results-from-a-randomized-supplementation-trial-in-uganda
#7
Anna E Coghill, Jeanette M Schenk, Zeina Mahkoul, Jackson Orem, Warren Phipps, Corey Casper
OBJECTIVE: Kaposi sarcoma (KS) is an HIV-associated malignancy caused by human herpesvirus-8 that occurs at highest incidence in sub-Saharan Africa. KS patients often present with inflammatory symptoms associated with higher mortality. DESIGN: We conducted a double-blind, randomized, placebo-controlled study in Uganda to test whether omega-3 (ω-3) supplementation could reduce inflammation in HIV and HHV-8 co-infected adults ≥ 18 years of age. Patients with acute illness, AIDS, or advanced KS were ineligible, as were pregnant women...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239682/safety-and-immunogenicity-of-a-seasonal-trivalent-inactivated-split-influenza-vaccine-a-phase-i-randomized-clinical-trial-in-healthy-serbian-adults
#8
Goran Stevanovic, Lidija Lavadinovic, Svetlana Filipovic Vignjevic, Renée Holt, Katarina Ilic, Francesco Berlanda Scorza, Erin Sparrow, Vera Stoiljkovic, Guido Torelli, Tamra Madenwald, Muriel Socquet, Aleksandra Barac, Yordanka Ilieva-Borisova, Mijomir Pelemis, Jorge Flores
This study was a phase I double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a Serbian-produced seasonal trivalent split, inactivated influenza vaccine in healthy adults. The vaccine was manufactured in eggs by the Torlak Institute of Virology, Vaccines and Sera, Belgrade, Serbia and contained A/H1N1, A/H3N2 and B viruses. The clinical trial took place at the Clinical Center of Serbia in Belgrade. Sixty healthy volunteers, aged 18-45 years, were enrolled in the trial...
December 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29239664/efficacy-and-safety-of-twice-daily-sustained-release-paracetamol-formulation-for-osteoarthritis-pain-of-the-knee-or-hip-a-randomized-double-blind-placebo-controlled-twelve-week-study
#9
Kenneth Reed, Agron Collaku, Sebastian Moreira
OBJECTIVE: Evaluate efficacy and safety of an investigational, twice-daily sustained-release (SR) paracetamol formulation in subjects with knee or hip osteoarthritis (OA). METHODS: In this multicenter, double-blind, parallel study (NCT02311881), subjects with hip or knee OA were randomly assigned to SR paracetamol 2x1000 mg BID, extended-release (ER) paracetamol 2x665 mg TID, or placebo for 12 weeks. Primary endpoint was mean change from baseline through 12 weeks in WOMAC Osteoarthritis Index pain...
December 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29238948/antioxidants-for-preventing-and-reducing-muscle-soreness-after-exercise
#10
REVIEW
Mayur K Ranchordas, David Rogerson, Hora Soltani, Joseph T Costello
BACKGROUND: Muscle soreness typically occurs after intense exercise, unaccustomed exercise or actions that involve eccentric contractions where the muscle lengthens while under tension. It peaks between 24 and 72 hours after the initial bout of exercise. Many people take antioxidant supplements or antioxidant-enriched foods before and after exercise in the belief that these will prevent or reduce muscle soreness after exercise. OBJECTIVES: To assess the effects (benefits and harms) of antioxidant supplements and antioxidant-enriched foods for preventing and reducing the severity and duration of delayed onset muscle soreness following exercise...
December 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29238824/effect-of-perioperative-gabapentin-on-postoperative-pain-resolution-and-opioid-cessation-in-a-mixed-surgical-cohort-a-randomized-clinical-trial
#11
Jennifer Hah, Sean C Mackey, Peter Schmidt, Rebecca McCue, Keith Humphreys, Jodie Trafton, Bradley Efron, Debra Clay, Yasamin Sharifzadeh, Gabriela Ruchelli, Stuart Goodman, James Huddleston, William J Maloney, Frederick M Dirbas, Joseph Shrager, John Costouros, Catherine Curtin, Ian Carroll
Importance: Guidelines recommend using gabapentin to decrease postoperative pain and opioid use, but significant variation exists in clinical practice. Objective: To determine the effect of perioperative gabapentin on remote postoperative time to pain resolution and opioid cessation. Design, Setting, and Participants: A randomized, double-blind, placebo-controlled trial of perioperative gabapentin was conducted at a single-center, tertiary referral teaching hospital...
December 13, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29238260/the-effect-of-400-%C3%A2%C2%B5g-inhaled-salbutamol-on-3-km-time-trial-performance-in-a-low-humidity-environment
#12
John Molphy, John W Dickinson, Neil J Chester, Mike Loosemore, Gregory Whyte
The Objectives of the study were to investigate whether 400 µg inhaled salbutamol influences 3 km running time-trial performance and lung function in eucapnic voluntary hyperpnoea positive (EVH+ve) and negative (EVH-ve) individuals. Fourteen male participants (22.4 ± 1.6yrs; 76.4 ± 8.7kg; 1.80 ± 0.07 m); (7 EVH+ve; 7 EVH-ve) were recruited following written informed consent. All participants undertook an EVH challenge to identify either EVH+ve (↓FEV1>10%) or EVH-ve (↓FEV1<10%). Participants performed three separate 3 km running time-trials in a low-humidity (20-25%) environment on a non-motorized treadmill, 15 minutes following inhalation of salbutamol (400 µg), placebo (non-active inhalant) or control (no inhalant), in a randomized, single-blind, repeated measures design...
December 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29238244/influence-of-a-thermogenic-dietary-supplement-on-safety-markers-body-composition-energy-expenditure-muscular-performance-and-hormone-concentrations-a-randomized-placebo-controlled-double-blind-trial
#13
Grant M Tinsley, Stacie Urbina, Jacy Mullins, Jordan Outlaw, Sara Hayward, Matt Stone, Cliffa Foster, Colin Wilborn, Lem Taylor
Dietary supplementation is commonly employed by individuals seeking to improve body composition and exercise performance. The purpose of the present study was to examine the safety and effectiveness of a commercially available dietary supplement designed to promote thermogenesis and fat loss. In a randomized double-blind trial, participants were assigned to consume placebo or a multi-ingredient supplement containing caffeine, green tea extract, l-carnitine, evodiamine and other ingredients that purportedly enhance thermogenesis...
December 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29238168/the-role-of-maintenance-therapy-in-the-treatment-of-elderly-non-small-cell-lung-cancer-patients-a-meta-analysis-of-randomized-controlled-trials
#14
Liangzhe Zhang, Shugeng Gao, Jie He
Purpose: Maintenance therapy is an effective treatment strategy for advanced non-small-cell lung cancer (NSCLC). We aim to investigate whether age would affect the efficacy of maintenance therapy in the treatment of advanced NSCLC. Materials and methods: Relevant trials were identified by searching electronic databases and conference meetings. Prospective randomized controlled trials assessing maintenance therapy in elderly patients with advanced NSCLC were included...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29238164/a-novel-transdermal-nanoethosomal-gel-of-betahistine-dihydrochloride-for-weight-gain-control-in-vitro-and-in-vivo-characterization
#15
Shahira F El-Menshawe, Adel Ahmed Ali, Abdelkhalk Ali Halawa, Ahmed Sg Srag El-Din
Background: Betahistine dihydrochloride (BDH) is a histamine analog used to control weight gain, with short elimination half-life and gastric irritation as side effects. Objective: The aim of the current investigation is to formulate and optimize a topical BDH ethosomal gel for weight gain control. Materials and methods: Box-Behnken design was applied to study the effect of independent variables: phosphatidylcholine (PC), propylene glycol (PG), and ethanol on vesicle size; entrapment efficiency; % drug release; and flux...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29237679/statin-effects-on-metabolic-profiles-data-from-the-prevend-it-prevention-of-renal-and-vascular-end-stage-disease-intervention-trial
#16
Daniel Kofink, Ruben N Eppinga, Wiek H van Gilst, Stephan J L Bakker, Robin P F Dullaart, Pim van der Harst, Folkert W Asselbergs
BACKGROUND: Statins lower cholesterol by inhibiting HMG-CoA reductase, the rate-limiting enzyme of the metabolic pathway that produces cholesterol and other isoprenoids. Little is known about their effects on metabolite and lipoprotein subclass profiles. We, therefore, investigated the molecular changes associated with pravastatin treatment compared with placebo administration using a nuclear magnetic resonance-based metabolomics platform. METHODS AND RESULTS: We performed metabolic profiling of 231 lipoprotein and metabolite measures in the PREVEND IT (Prevention of Renal and Vascular End-stage Disease Intervention Trial) study, a placebo-controlled randomized clinical trial designed to test the effects of pravastatin (40 mg once daily) on cardiovascular risk...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29237099/calcium-channel-blockers-for-primary-and-secondary-raynaud-s-phenomenon
#17
REVIEW
Fadumo Rirash, Paul C Tingey, Sarah E Harding, Lara J Maxwell, Elizabeth Tanjong Ghogomu, George A Wells, Peter Tugwell, Janet Pope
BACKGROUND: Raynaud's phenomenon is a vasospastic disease characterized by digital pallor, cyanosis, and extremity pain. Primary Raynaud's phenomenon is not associated with underlying disease, but secondary Raynaud's phenomenon is associated with connective tissue disorders such as systemic sclerosis, systemic lupus erythematosus, and mixed connective tissue disease. Calcium channel blockers promote vasodilation and are commonly used when drug treatment for Raynaud's phenomenon is required...
December 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29237033/colchicine-for-prevention-of-perioperative-atrial-fibrillation-in-patients-undergoing-lung-resection-surgery-a-pilot-randomized-controlled-study
#18
Amal Bessissow, John Agzarian, Yaron Shargall, Sadeesh Srinathan, John Neary, Vikas Tandon, Christian Finley, Jeff S Healey, David Conen, Reitze Rodseth, Shirley Pettit, William Dechert, Otto Regalado, Chinthanie Ramasundarahettige, Saleh Alshalash, P J Devereaux
OBJECTIVES: We carried out a pilot randomized controlled study to determine the feasibility of a large trial evaluating the impact of colchicine versus placebo on postoperative atrial fibrillation or atrial flutter (POAF) among patients undergoing lung resection surgery. METHODS: Patients ≥55 years of age undergoing lung resection surgery were randomly assigned to receive colchicine 0.6 mg or placebo starting a few hours before surgery. Postoperatively, patients received colchicine 0...
December 9, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29236734/freeze-dried-lactobacillus-plantarum-299v-increases-iron-absorption-in-young-females-double-isotope-sequential-single-blind-studies-in-menstruating-women
#19
Michael Hoppe, Gunilla Önning, Lena Hulthén
BACKGROUND: The probiotic strain Lactobacillus plantarum 299v has earlier been shown to increase iron absorption when added to foods. However, it is not known if the same probiotic strain in a freeze-dried format included in a capsule increases the iron absorption. OBJECTIVE: The aim of this study was to test the hypotheses that non-heme iron absorption from a light meal is promoted by a simultaneous intake of freeze-dried Lactobacillus plantarum 299v (Lp299v, DSM 9843)...
2017: PloS One
https://www.readbyqxmd.com/read/29236711/magnetic-resonance-imaging-of-the-hand-and-wrist-in-a-randomized-double-blind-multicenter-placebo-controlled-trial-of-infliximab-for-rheumatoid-arthritis-comparison-of-dynamic-contrast-enhanced-assessments-with-semi-quantitative-scoring
#20
Chan Beals, Richard Baumgartner, Charles Peterfy, Andra Balanescu, Gavrila Mirea, Alexandru Harabagiu, Serghei Popa, Amy Cheng, Dai Feng, Edward Ashton, Julie DiCarlo, Marie-Helene Vallee, Bernard J Dardzinski
The objective of this study was to compare the scope and the discriminative power of Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) to those of semi-quantitative MRI scoring for evaluating treatments for rheumatoid arthritis (RA) in multicenter randomized clinical trials (RCTs). Sixty-one patients with active RA participated in a double-blind, parallel group, randomized, multicenter methodology study receiving infliximab or placebo through 14 weeks. The most symptomatic wrist and metacarpophalangeal joints (MCPs) were imaged using MRI...
2017: PloS One
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