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https://www.readbyqxmd.com/read/29694707/efficacy-and-safety-of-a-hexanic-extract-of-serenoa-repens-permixon-%C3%A2-for-the-treatment-of-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia-luts-bph-systematic-review-and-meta-analysis-of-randomized-controlled-trials-and-observational
#1
Remigio Vela-Navarrete, Antonio Alcaraz, Alfredo Rodríguez-Antolín, Bernardino Miñana López, Jesús M Fernández-Gómez, Javier C Angulo, David Castro Díaz, Javier Romero-Otero, Francisco J Brenes, Joaquín Carballido, José M Molero García, Antonio Fernández-Pro Ledesma, José Manuel Cózar Olmos, José Manasanch Dalmau, Isaac Subirana Cachinero, Michael Herdman, Vincenzo Ficarra
OBJECTIVES: To comprehensively evaluate the efficacy and safety of the hexanic extract of Serenoa repens (HESr, Permixon), at a dose of 320 mg daily, as monotherapy for the treatment of LUTS/BPH. MATERIALS AND METHODS: Systematic review and meta-analysis of randomized and observational studies in patients with LUTS/BPH identified through searches in Medline, Web of Knowledge [ISI], Scopus, the Cochrane Library, and bibliographic references up to March 2017. Articles studying S...
April 25, 2018: BJU International
https://www.readbyqxmd.com/read/29694506/dietary-intake-and-eating-behavior-in-depot-medroxyprogesterone-acetate-users-a-systematic-review
#2
P Silva, S Qadir, A Fernandes, L Bahamondes, J F Peipert
Because of weight gain, women often discontinue hormonal contraception, especially depot medroxyprogesterone acetate (DMPA). Our objective was to conduct a systematic review of studies describing dietary intake or eating behavior in DMPA users to understand whether the use of DMPA is associated with changes in dietary habits and behaviors leading to weight gain. We searched the PubMed, POPLINE, CENTRAL Cochrane, Web of Science, and EMBASE databases for reports published in English between 1980 and 2017 examining dietary intake or eating behavior in healthy women in reproductive age and adolescents using DMPA (150 mg/mL)...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29694465/melatonin-treatment-in-patients-with-burning-mouth-syndrome-a-triple-blind-placebo-controlled-crossover-randomized-clinical-trial
#3
Elena M Varoni, Alfredo F Lo Faro, Giovanni Lodi, Antonio Carrassi, Marcello Iriti, Andrea Sardella
AIMS: To evaluate the efficacy of melatonin compared to placebo in reducing pain associated with burning mouth syndrome (BMS), as well as side effects of treatment and effects on sleep quality, anxiety, and serum and salivary melatonin levels. METHODS: In this triple-blind, randomized clinical trial, 20 BMS patients (mean age ± standard deviation: 64.4 ± 11.5 years; range: 35 to 82 years) were enrolled to receive melatonin (12 mg/day) or placebo for 8 weeks in a crossover design...
April 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29694378/comparison-of-acupuncture-and-other-drugs-for-chronic-constipation-a-network-meta-analysis
#4
Lingping Zhu, Yunhui Ma, Xiaoyan Deng
The objective of this study was to compare the efficacy and side effects of acupuncture, sham acupuncture and drugs in the treatment of chronic constipation. Randomized controlled trials (RCTs) assessing the effects of acupuncture and drugs for chronic constipation were comprehensively retrieved from electronic databases (such as PubMed, Cochrane Library, Embase, CNKI, Wanfang Database, VIP Database and CBM) up to December 2017. Additional references were obtained from review articles. With quality evaluations and data extraction, a network meta-analysis (NMA) was performed using a random-effects model under a frequentist framework...
2018: PloS One
https://www.readbyqxmd.com/read/29693757/adjunctive-probiotic-microorganisms-to-prevent-rehospitalization-in-patients-with-acute-mania-a-randomized-controlled-trial
#5
Faith Dickerson, Maria Adamos, Emily Katsafanas, Sunil Khushalani, Andrea Origoni, Christina Savage, Lucy Schweinfurth, Cassie Stallings, Kevin Sweeney, Joshana Goga, Robert H Yolken
OBJECTIVE: Immunological abnormalities play a role in the pathophysiology of mania and have been associated with relapse. Probiotic organisms such as Lactobacilli and Bifidobacteria modulate inflammation in humans and animal models. The trial examined whether the administration of probiotic organisms prevents psychiatric rehospitalizations in patients recently discharged following hospitalization for mania. METHODS: Patients hospitalized for mania (N = 66) were randomized after discharge to receive 24 weeks of adjunctive probiotics (Lactobacillus rhamnosus strain GG and Bifidobacterium animalis subsp...
April 25, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29693495/a-randomized-clinical-trial-of-nicotine-preloading-for-smoking-cessation-in-people-with-posttraumatic-stress-disorder
#6
Eric A Dedert, Paul A Dennis, Patrick S Calhoun, Michelle F Dennis, Jean C Beckham
OBJECTIVE: To determine whether augmenting standard smoking cessation treatment by wearing an active nicotine patch before the smoking quit date improves rates of smoking cessation in individuals with posttraumatic stress disorder (PTSD), and to explore mechanisms of treatment response such as decreased cigarette craving and symptom relief from smoking. METHODS: Double-blind parallel randomized controlled trial in 81 people with PTSD who smoked cigarettes. Participants were recruited from Veterans Affairs outpatient clinics and flyers in the community...
April 25, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29693459/evaluating-the-effectiveness-of-systemic-corticosteroids-to-mitigate-relapse-in-children-assessed-and-treated-for-acute-asthma-a-network-meta-analysis
#7
Scott W Kirkland, Ben Vandermeer, Sandy Campbell, Cristina Villa-Roel, Amanda Newton, Francine M Ducharme, Brian H Rowe
OBJECTIVE: The objective of this systematic review was to explore the effectiveness of various systemic corticosteroid (SCS) regimens to mitigate relapse in children with asthma discharged from an acute care setting. DATA SOURCES: Medline, EMBASE, Global Health, International Pharmaceutical Abstracts, EMB ALL, CINAHL, SCOPUS, Proquest Dissertations and Theses Global, and LILACS were searched using controlled vocabulary and key words. Additional citations were searched via clinical trial registries, Google Scholar, bibliographies, a SCOPUS forward search of a sentinel paper, and hand searching conference abstracts...
April 25, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29692179/an-indirect-comparison-of-intravenous-and-subcutaneous-belimumab-efficacy-in-patients-with-sle-and-high-disease-activity
#8
Sulabha Ramachandran, Daniel Parks, Milena Kurtinecz, David A Roth, Rafael Alfonso-Cristancho
AIM: To compare the efficacy of intravenous (IV) and subcutaneous (SC) belimumab plus standard therapy in patients with active, autoantibody-positive systemic lupus erythematosus and high disease activity (HDA). PATIENTS & METHODS: An indirect treatment comparison using patient-level data of patients with HDA from three belimumab IV Phase III randomized controlled trials (BLISS-52 [BEL110751]; BLISS-76 [BEL110752]; North-East Asia Study [BEL113750]) and one belimumab SC randomized controlled trial (BLISS-SC [BEL112341])...
April 25, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29691835/rufinamide-add-on-therapy-for-refractory-epilepsy
#9
REVIEW
Mariangela Panebianco, Hemanshu Prabhakar, Anthony G Marson
BACKGROUND: Epilepsy is a central nervous system disorder (neurological disorder). Epileptic seizures are the result of excessive and abnormal cortical nerve cell electrical activity in the brain. Despite the development of more than 10 new antiepileptic drugs (AEDs) since the early 2000s, approximately a third of people with epilepsy remain resistant to pharmacotherapy, often requiring treatment with a combination of AEDs. In this review, we summarised the current evidence regarding rufinamide, a novel anticonvulsant medication, which, as a triazole derivative, is structurally unrelated to any other currently used anticonvulsant medication, when used as an add-on treatment for refractory epilepsy...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29691773/etelcalcetide-for-treating-secondary-hyperparathyroidism-an-evidence-review-group-evaluation-of-a-nice-single-technology-appraisal
#10
Micah Rose, Jonathan Shepherd, Petra Harris, Karen Pickett, Joanne Lord
The manufacturer of the calcimimetic drug etelcalcetide was invited to make an evidence submission as part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal (STA) programme. Within this submission, they reported evidence on the clinical and cost effectiveness of etelcalcetide for the treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) on haemodialysis. The Southampton Health Technology Assessments Centre (SHTAC), part of the Wessex Institute at the University of Southampton, was the independent Evidence Review Group (ERG) commissioned to appraise the company's submission...
April 25, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29691250/long-term-neuroprotective-effect-of-erythropoietin-on-executive-functions-in-very-preterm-children-epokids-protocol-of-a-prospective-follow-up-study
#11
Flavia Maria Wehrle, Ulrike Held, Ruth Tuura O'Gorman, Vera Disselhoff, Barbara Schnider, Jean-Claude Fauchère, Petra Hüppi, Beatrice Latal, Cornelia Franziska Hagmann
INTRODUCTION: Premature infants are particularly vulnerable to brain injuries with associated cognitive and behavioural deficits. The worldwide first randomised interventional multicentre trial investigating the neuroprotective effects of erythropoietin (entitled 'Does erythropoietin improve outcome in very preterm infants?' (NCT00413946)) included 450 very preterm infants in Switzerland. MRI at term equivalent age showed less white matter (WM) injury in the erythropoietin group compared with the placebo group...
April 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29691101/influenza-vaccination-in-the-elderly-is-a-trial-on-mortality-ethically-acceptable
#12
Ruud Andreas Fritz Verhees, Wybo Dondorp, Carel Thijs, Geert Jan Dinant, Johannes Andreas Knottnerus
The effectiveness of influenza vaccination in the elderly has long been a topic of debate, fueled by the absence of direct evidence from randomized trials on its effect on mortality and the methodological limitations of observational studies pointing this direction. It is argued that new placebo-controlled trials should be undertaken to resolve this uncertainty. However, such trials may be ethically questionable. To bring this discussion forward, we provide a comprehensive overview of the ethical challenges of an influenza vaccine efficacy trial designed to evaluate mortality in the elderly...
April 21, 2018: Vaccine
https://www.readbyqxmd.com/read/29690626/effects-of-chlorogenic-acid-enriched-and-hydroxyhydroquinone-reduced-coffee-on-postprandial-fat-oxidation-and-antioxidative-capacity-in-healthy-men-a-randomized-double-blind-placebo-controlled-crossover-trial
#13
Shun Katada, Takuya Watanabe, Tomohito Mizuno, Shinichi Kobayashi, Masao Takeshita, Noriko Osaki, Shigeru Kobayashi, Yoshihisa Katsuragi
Chlorogenic acids (CGAs) reduce blood pressure and body fat, and enhance fat metabolism. In roasted coffee, CGAs exist together with the oxidant component hydroxyhydroquinone (HHQ). HHQ counteracts the antihypertensive effects of CGA, but its effects on CGA-induced fat oxidation (FOX) are unknown. Here we assessed the effects of CGA-enriched and HHQ-reduced coffee on FOX. Fifteen healthy male volunteers (age: 38 ± 8 years (mean ± SD); BMI: 22.4 ± 1.5 kg/m²) participated in this crossover study...
April 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29690620/silk-route-to-the-acceptance-and-re-implementation-of-bacteriophage-therapy-part-ii
#14
Wilbert Sybesma, Christine Rohde, Pavol Bardy, Jean-Paul Pirnay, Ian Cooper, Jonathan Caplin, Nina Chanishvili, Aidan Coffey, Daniel De Vos, Amber Hartman Scholz, Shawna McCallin, Hilke Marie Püschner, Roman Pantucek, Rustam Aminov, Jiří Doškař, D İpek Kurtbӧke
This perspective paper follows up on earlier communications on bacteriophage therapy that we wrote as a multidisciplinary and intercontinental expert-panel when we first met at a bacteriophage conference hosted by the Eliava Institute in Tbilisi, Georgia in 2015. In the context of a society that is confronted with an ever-increasing number of antibiotic-resistant bacteria, we build on the previously made recommendations and specifically address how the Nagoya Protocol might impact the further development of bacteriophage therapy...
April 23, 2018: Antibiotics
https://www.readbyqxmd.com/read/29689693/vortioxetine-improves-symptomatic-and-functional-outcomes-in-major-depressive-disorder-a-novel-dual-outcome-measure-in-depressive-disorders
#15
Michael Cronquist Christensen, Henrik Loft, Roger S McIntyre
BACKGROUND: With symptomatic remission and functional recovery as the overarching therapeutic objectives of antidepressant therapy, composite endpoint measures that conjointly consider both aspects of treatment are needed. This analysis evaluated the combined effect of vortioxetine on depressive symptoms and functional capacity in adults with MDD. METHODS: NCT01564862, a multinational, double-blind, placebo-controlled, duloxetine-referenced study, conducted between April 2012 and February 2014, in 602 adult outpatients (18-65 years) with moderate-to-severe MDD (Montgomery-Åsberg Depression Rating Scale (MADRS) ≥ 26), a major depressive episode of ≥ 3 months' duration, and self-reported cognitive symptoms were randomized to once-daily vortioxetine (10 or 20mg), duloxetine (60mg), or placebo for 8 weeks...
February 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29689482/adventure-based-training-to-promote-physical-activity-and-reduce-fatigue-among-childhood-cancer-survivors-a-randomized-controlled-trial
#16
William H C Li, K Y Ho, K K W Lam, H S Lam, S Y Chui, Godfrey C F Chan, A T Cheung, L L K Ho, O K Chung
BACKGROUND: Cancer-related fatigue is one of the most distressing symptoms reported by childhood cancer survivors. Despite the body of evidence that regular physical activity helps alleviate cancer-related fatigue, insufficient participation in physical activity is frequently observed among childhood cancer survivors. OBJECTIVES: This study examined the effectiveness of an adventure-based training programme in promoting physical activity, reducing fatigue, and enhancing self-efficacy and quality of life among Hong Kong Chinese childhood cancer survivors...
April 14, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29689326/analysis-of-spin-in-the-reporting-of-studies-of-topical-treatments-of-photoaged-skin
#17
Catherine C Motosko, Anna K Ault, Laura L Kimberly, M David Gothard, Roger S Ho, Alexes Hazen
BACKGROUND: Spin-reporting that distorts the interpretation of results-is not unusual within scientific literature. OBJECTIVE: To appraise strategies of spin among placebo-controlled double-blind clinical trials of topical treatments for photoaged skin. METHODS: A systematic review of literature was performed to identify placebo-controlled double-blind clinical trials of topical treatments for photoaged skin. A survey of spin strategies was developed and applied to the cohort of identified studies...
April 21, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29689257/use-of-diphenhydramine-as-an-adjunctive-sedative-for-colonoscopy-in-patients-on-chronic-opioid-therapy-a-randomized-controlled-trial
#18
Salman Nusrat, Mohammed F Madhoun, William M Tierney
BACKGROUND AND AIMS: Chronic opioid use increases tolerance to sedatives. Diphenhydramine is recommended for difficult-to-sedate patients during endoscopic procedures. We hypothesized that the addition of diphenhydramine to midazolam and fentanyl would improve objective and subjective measures of procedural sedation. METHODS: This randomized, double-blind, placebo-controlled trial included patients on chronic opioids undergoing colonoscopy. Patients were randomized to receive intravenous 50 mg of diphenhydramine (N=61) or placebo (N=58), in addition to fentanyl and midazolam...
April 21, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29688920/mixed-treatment-comparisons-for-nonsurgical-treatment-of-knee-osteoarthritis-a-network-meta-analysis
#19
David S Jevsevar, Peter B Shores, Kyle Mullen, Danielle M Schulte, Gregory A Brown, Deborah S Cummins
INTRODUCTION: Knee osteoarthritis (KOA) is a significant health problem with lifetime risk of development estimated to be 45%. Effective nonsurgical treatments are needed for the management of symptoms. METHODS: We designed a network meta-analysis to determine clinically relevant effectiveness of nonsteroidal anti-inflammatory drugs, acetaminophen, intra-articular (IA) corticosteroids, IA platelet-rich plasma, and IA hyaluronic acid compared with each other as well as with oral and IA placebos...
May 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29688915/clinical-and-microbiological-effect-of-a-multispecies-probiotic-supplementation-in-celiac-patients-with-persistent-ibs-type-symptoms-a-randomized-double-blind-placebo-controlled-multicenter-trial
#20
Ruggiero Francavilla, Maria Piccolo, Antonio Francavilla, Lorenzo Polimeno, Francesco Semeraro, Fernanda Cristofori, Stefania Castellaneta, Michele Barone, Flavia Indrio, Marco Gobbetti, Maria De Angelis
GOALS: The goals of this study were to evaluate the efficacy and safety of a probiotic mixture in patients with celiac disease (CD) with irritable bowel syndrome (IBS)-type symptoms despite a strict gluten-free diet (GFD). BACKGROUND: About 30% of patients with CD adherent to a GFD suffer from IBS-type symptoms; a possible cause resides in the imbalances of the intestinal microbiota in CD. Probiotics may represent a potential treatment. STUDY: CD patients with IBS-type symptoms entered a prospective, double-blind, randomized placebo-controlled study...
April 23, 2018: Journal of Clinical Gastroenterology
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