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https://www.readbyqxmd.com/read/29769455/tenascin-c-a-potential-biomarker-for-predicting-the-severity-of-coronary-atherosclerosis
#1
Wen Gao, Jian Li, Huanchun Ni, Haiming Shi, Zhiyong Qi, Shouguo Zhu, Chuanming Hao, Qionghong Xie, Xinping Luo, Kun Xie
AIMS: Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide and one of the greatest threats to public health. Tenascin C (TNC) is an extracellular matrix glycoprotein that is found in low concentrations in normal tissues and is enhanced by a range of cardiovascular pathologies. This study aimed to evaluate the value of TNC in assessing the severity of atherosclerosis measured by the Gensini score. METHODS: A total of 157 patients with chest pains who underwent selective coronary angiography for suspected coronary atherosclerosis were enrolled...
May 17, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29768317/heart-failure-episodes-of-missed-major-cardiac-events-when-applying-the-heart-pathway-to-an-observation-unit-population
#2
Alan Tesson, Rami Abdo, Aparna Kamath, Joanne Sutter, Rachel Cline, Sarah L Hale, Jonathan Bae, Lalit Verma
OBJECTIVE: The HEART Pathway risk prediction tool (HEART score plus serial troponin measures at 0 and 3 hours post-presentation) is used to identify low-risk patients with chest pain who may qualify for safe, early discharge. We calculated the percentage of patients in our observation unit that qualified as low risk using HEART Pathway, as well as their associated outcomes. METHODS: We retrospectively reviewed charts on 966 consecutive patients admitted to our observation unit for chest pain (January 2015 to February 2016); HEART Pathway scores were retrospectively calculated and serial cardiac troponin values logged...
June 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29760864/3-for-the-price-of-1-teaching-chest-pain-risk-stratification-in-a-multidisciplinary-problem-based-learning-workshop
#3
William D Alley, Cynthia Burns, Nicholas D Hartman, Kim Askew, Simon A Mahler
Introduction: Chest pain is a common chief complaint among patients presenting to health systems and often leads to complex and intensive evaluations. While these patients are often cared for by a multidisciplinary team (primary care, emergency medicine, and cardiology), medical students usually learn about the care of these patients in a fragmented, single-specialty paradigm. The present and future care of patients with chest pain is multidisciplinary, and the education of medical students on the subject should be as well...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29756524/chest-pain-atherosclerotic-cardiovascular-disease-risk-and-cardiology-referral-in-primary-care
#4
Vishaal Buch, Hayley Ralph, Joanne Salas, Paul J Hauptman, Dawn Davis, Jeffrey F Scherrer
BACKGROUND: The atherosclerotic cardiovascular disease (ASCVD) 10-year risk estimate is recommended by cardiologists for determining risk of a cardiac event. However, the majority of patients presenting to primary care with chest pain have noncardiac etiologies. Therefore, we determined if high versus low ASCVD risk was associated with primary care physicians' referral to cardiology in patients with and without chest pain. METHODS: Deidentified electronic health record (EHR) data was obtained from 5795 patients treated in academic primary care clinics from 2008 to 2015...
January 2018: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/29707336/values-of-aortic-dissection-detection-risk-score-combined-with-ascending-aorta-diameter-40-mm-for-the-early-identification-of-type-a-acute-aortic-dissection
#5
Di Wang, Zhi-Yan Wang, Ju-Fang Wang, Li-Li Zhang, Ju-Mo Zhu, Zhong-Xiang Yuan, Yi Wang
Background: Type A acute aortic dissection (A-AAD), involving the ascending aorta, is a life-threatening disease. To detect A-AAD early and rapidly in patients with acute chest pain, especially in patients with acute myocardial infarction (AMI) secondary to A-AAD, we investigated values of combined use of the risk score and the ascending aorta diameter >40 mm for the early identification of A-AAD. Methods: Our study retrospectively encompassed 239 patients with acute chest pain on admission to our hospital between July 2010 and December 2016...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29703635/differences-in-the-association-of-total-versus-local-coronary-artery-calcium-with-acute-coronary-syndrome-and-culprit-lesions-in-patients-with-acute-chest-pain-the-coronary-calcium-paradox
#6
Stefan B Puchner, Thomas Mayrhofer, Jakob Park, Michael T Lu, Ting Liu, Pal Maurovich-Horvat, Khristine Ghemigian, Daniel O Bittner, Jerome L Fleg, James E Udelson, Quynh A Truong, Udo Hoffmann, Maros Ferencik
BACKGROUND AND AIMS: Total coronary artery calcium (CAC) burden is associated with an increased cardiovascular risk, while local CAC may represent stable plaques. We determined differences in relationship of total CAC with acute coronary syndrome (ACS) and local CAC with culprit lesions in patients with suspected ACS. METHODS: We performed computed tomography (CT) for CAC and CT angiography to assess the presence of significant stenosis and high-risk plaque (positive remodeling, low CT attenuation, napkin-ring sign, spotty calcium) in 37 patients with ACS and 223 controls...
April 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29687656/cha-2-ds-2-vasc-score-and-clinical-outcomes-of-patients-with-chest-pain-discharged-from-internal-medicine-wards-following-acute-coronary-syndrome-rule-out
#7
Guy Topaz, Ory Haisraely, Yacov Shacham, Gil Beery, Lotan Shilo, Nuha Kassem, David Pereg, Yona Kitay-Cohen
BACKGROUND: Chest-pain patients deemed safe for discharge from internal medicine wards might still be at risk for adverse outcomes. HYPOTHESIS: CHA2 DS2 -VASc score improves risk stratification of low-risk chest-pain patients discharged after acute coronary syndrome (ACS) rule-out. METHODS: We accessed medical records of patients who were admitted to internal medicine wards at a single medical center during 2010-2016 and discharged following an ACS rule-out...
April 23, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29680338/a-comparison-of-the-updated-diamond-forrester-cad-consortium-and-confirm-history-based-risk-scores-for-predicting-obstructive-coronary-artery-disease-in-patients-with-stable-chest-pain-the-scot-heart-coronary-cta-cohort
#8
Lohendran Baskaran, Ibrahim Danad, Heidi Gransar, Bríain Ó Hartaigh, Joshua Schulman-Marcus, Fay Y Lin, Jessica M Peña, Amanda Hunter, David E Newby, Philip D Adamson, James K Min
OBJECTIVES: This study sought to compare the performance of history-based risk scores in predicting obstructive coronary artery disease (CAD) among patients with stable chest pain from the SCOT-HEART study. BACKGROUND: Risk scores for estimating pre-test probability of CAD are derived from referral-based populations with a high prevalence of disease. The generalizability of these scores to lower prevalence populations in the initial patient encounter for chest pain is uncertain...
April 13, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29672210/prognostic-utility-of-stress-testing-and-cardiac-biomarkers-in-menopausal-women-at-low-to-intermediate-risk-for-coronary-artery-disease-smart-study-5-year-outcome
#9
Sahar S Abdelmoneim, Caroline A Ball, Francesca Mantovani, Mary E Hagen, Susan Eifert-Rain, Susan Wilansky, Ramon Castello, Patricia A Pellikka, Patricia J M Best, Sharon L Mulvagh
BACKGROUND: In women with low to intermediate risk of coronary artery disease (CAD), prognostic detection strategies have been controversial. We present the follow-up data of the SMART trial in peri/postmenopausal women at low to intermediate risk of CAD. OBJECTIVES: To determine the value of contrast stress echocardiography (CSE), stress electrocardiogram (sECG), and serum biomarkers for prediction of cardiovascular events (CE) in peri/postmenopausal women at low to intermediate risk of CAD...
April 19, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29669793/impacts-of-prediabetes-mellitus-alone-or-plus-hypertension-on-the-coronary-severity-and-cardiovascular-outcomes
#10
Hui-Hui Liu, Ye-Xuan Cao, Sha Li, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Qiu-Ting Dong, Xi Zhao, Yan Zhang, Di Sun, Jian-Jun Li
Whether prediabetes mellitus (Pre-DM) alone or combined with hypertension is an independent risk factor for cardiovascular disease has not been fully clarified. This study aimed to further confirm whether the relation of Pre- DM to cardiovascular disease differs between individuals with or without hypertension. A total of 7121 consecutive patients with angina-like chest pain who received coronary angiography were evaluated and 4193 patients with angiography-proven stable, new-onset coronary artery disease were enrolled into the study...
April 18, 2018: Hypertension
https://www.readbyqxmd.com/read/29652166/ambulance-use-distance-and-outcomes-in-patients-with-suspected-cardiovascular-disease-a-registry-based-geographic-information-system-study
#11
Nariman Sepehrvand, Wendimagegn Alemayehu, Padma Kaul, Rick Pelletier, Aminu K Bello, Robert C Welsh, Paul W Armstrong, Justin A Ezekowitz
BACKGROUND: Despite guideline recommendations, the majority of patients with symptoms suggestive of acute coronary syndrome do not use emergency medical services to reach the emergency department (ED). The aim of this study was to investigate the factors associated with EMS utilisation and subsequent patient outcomes. METHODS: Using administrative data, all patients who presented to an ED in the metropolitan areas of Edmonton and Calgary in the years of 2007-2013 with main ED diagnosis of acute coronary syndrome, stable angina or chest pain were included...
April 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29622596/risk-stratifying-chest-pain-patients-in-the-emergency-department-using-heart-grace-and-timi-scores-with-a-single-contemporary-troponin-result-to-predict-major-adverse-cardiac-events
#12
Peter D W Reaney, Hamish I Elliott, Awsan Noman, Jamie G Cooper
BACKGROUND: The majority of patients presenting to the ED with cardiac sounding chest pain have a non-diagnostic ECG and the problem of differentiating those suffering an acute coronary syndrome from those without is familiar to all ED clinical staff. To stratify risk in these patients, specific scores have been developed. Recent work has focused on incorporating newer high-sensitivity cardiac troponin (hs-cTn) assays; however, issues regarding performance and availability of these assays remain...
April 5, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29611430/diagnostic-accuracy-of-the-electrocardiographic-decision-support-myocardial-ischaemia-eds-mi-algorithm-in-detection-of-acute-coronary-occlusion
#13
Thomas Lindow, Olle Pahlm, Charles W Olson, Ardavan Khoshnood, Ulf Ekelund, Marcus Carlsson, Cees A Swenne, Sumche Man, Henrik Engblom
Electrocardiographic Decision Support - Myocardial Ischaemia (EDS-MI) is a graphical decision support for detection and localization of acute transmural ischaemia. A recent study indicated that EDS-MI performs well for detection of acute transmural ischaemia. However, its performance has not been tested in patients with non-ischaemic ST-deviation. We aimed to optimize the diagnostic accuracy of EDS-MI in patients with verified acute coronary occlusion as well as patients with non-ischaemic ST deviation and compare its performance with STEMI criteria...
April 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29603377/lipoprotein-a-level-associates-with-coronary-artery-disease-rather-than-carotid-lesions-in-patients-with-familial-hypercholesterolemia
#14
Di Sun, Bing-Yang Zhou, Xi Zhao, Sha Li, Cheng-Gang Zhu, Yuan-Lin Guo, Ying Gao, Na-Qiong Wu, Geng Liu, Qian Dong, Jian-Jun Li
BACKGROUND: Lipoprotein(a) [Lp(a)] level is a novel risk factor for atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia (FH), while its impact on the different sites of arteries remains undetermined. We aim to examine the associations of Lp(a) levels with coronary and carotid atherosclerosis in patients with heterozygous FH (HeFH). METHODS: A total of 148 patients with HeFH who have received carotid ultrasonography and coronary angiography due to chest pain were enrolled...
March 30, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29587906/-a-comparative-study-of-acute-and-chronic-pain-between-single-port-and-triple-port-video-assisted-thoracic-surgery-for-lung-cancer
#15
Caiwei Li, Meiqing Xu, Guangwen Xu, Ran Xiong, Hanran Wu, Mingran Xie
BACKGROUND: Through the comparative analysis of the acute and chronic pain postoperative between the single port and triple port video-assisted thoracic surgery to seek the better method which can reduce the incidence of acute and chronic pain in patients with lung cancer. METHODS: Data of 232 patients who underwent single port -VATS (n=131) or triple port VATS (n=101) for non-small cell lung cancer (NSCLC) on January 1, 2016 to June 30, 2017 in our hospital were analyzed...
April 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29577524/pulmonary-infarction-secondary-to-pulmonary-embolism-an-evolving-paradigm
#16
Marjan Islam, Jason Filopei, Matthew Frank, Navitha Ramesh, Stacey Verzosa, Madeline Ehrlich, Eric Bondarsky, Albert Miller, David Steiger
BACKGROUND AND OBJECTIVE: Pulmonary infarction (PI) from pulmonary embolism (PE) remains an entity of unclear aetiology. PI has been thought to occur in elderly patients with cardiopulmonary disease. We hypothesize younger patients without cardiopulmonary comorbidities are at highest risk. Our study aims to characterize PI clinically and radiographically, determine associated risk factors and determine their clinical significance. METHODS: We conducted a single-centre retrospective review of 367 consecutive patients with PE...
March 25, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29574581/new-algorithm-for-the-prediction-of-cardiovascular-risk-in-symptomatic-adults-with-stable-chest-pain
#17
REVIEW
Muralidhar R Papireddy, Carl J Lavie, Abhizith Deoker, Hadii Mamudu, Timir K Paul
PURPOSE OF REVIEW: To review the landmark studies in predicting obstructive coronary artery disease (CAD) in symptomatic patients with stable chest pain and identify better prediction tools and propose a simplified algorithm to guide the health care providers in identifying low risk patients to defer further testing. RECENT FINDINGS: There are a few risk prediction models described for stable chest pain patients including Diamond-Forrester (DF), Duke Clinical Score (DCS), CAD Consortium Basic, Clinical, and Extended models...
March 24, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29562761/the-value-of-big-endothelin-1-in-the-assessment-of-the-severity-of-coronary-artery-calcification
#18
Fang Wang, Tiewei Li, Xiangfeng Cong, Zhihui Hou, Bin Lu, Zhou Zhou, Xi Chen
Progression of coronary artery calcification (CAC) was significantly associated with all-cause mortality, and high coronary artery calcium score (CACS) portends a particularly high risk of cardiovascular events. But how often one should rescan is still an unanswered question. Preliminary screening by testing circulating biomarker may be an alternative before repeat computed tomography (CT) scan. The aim of this study was to investigate the value of big endothelin-1 (bigET-1), the precursor of endothelin-1 (ET-1), in predicting the severity of CAC...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29556770/applicability-and-accuracy-of-pretest-probability-calculations-implemented-in-the-nice-clinical-guideline-for-decision-making-about-imaging-in-patients-with-chest-pain-of-recent-onset
#19
Robert Roehle, Viktoria Wieske, Georg M Schuetz, Pascal Gueret, Daniele Andreini, Willem Bob Meijboom, Gianluca Pontone, Mario Garcia, Hatem Alkadhi, Lily Honoris, Jörg Hausleiter, Nuno Bettencourt, Elke Zimmermann, Sebastian Leschka, Bernhard Gerber, Carlos Rochitte, U Joseph Schoepf, Abbas Arjmand Shabestari, Bjarne Nørgaard, Akira Sato, Juhani Knuuti, Matthijs F L Meijs, Harald Brodoefel, Shona M M Jenkins, Kristian Altern Øvrehus, Axel Cosmus Pyndt Diederichsen, Ashraf Hamdan, Bjørn Arild Halvorsen, Vladimir Mendoza Rodriguez, Yung Liang Wan, Johannes Rixe, Mehraj Sheikh, Christoph Langer, Said Ghostine, Eugenio Martuscelli, Hiroyuki Niinuma, Arthur Scholte, Konstantin Nikolaou, Geir Ulimoen, Zhaoqi Zhang, Hans Mickley, Koen Nieman, Philipp Kaufmann, Ronny Ralf Büchel, Bernhard Herzog, Melvin Clouse, David A Halon, Jonathan Leipsic, David Bush, Reda Jakamy, Kai Sun, Lin Yang, Thorsten Johnson, Jean-Pierre Laissy, Roy Marcus, Simone Muraglia, Jean-Claude Tardif, Benjamin Chow, Narinder Paul, David Maintz, John Hoe, Albert de Roos, Robert Haase, Michael Laule, Peter Schlattmann, Marc Dewey
OBJECTIVES: To analyse the implementation, applicability and accuracy of the pretest probability calculation provided by NICE clinical guideline 95 for decision making about imaging in patients with chest pain of recent onset. METHODS: The definitions for pretest probability calculation in the original Duke clinical score and the NICE guideline were compared. We also calculated the agreement and disagreement in pretest probability and the resulting imaging and management groups based on individual patient data from the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT)...
March 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29549371/triaging-primary-care-patients-referred-for-chest-pain-to-specialist-cardiology-centres-efficacy-of-an-optimised-protocol
#20
Francine Cl Tan, Jonathan Yap, John C Allen, Olivia Tan, Swee Yaw Tan, David B Matchar, Terrance Sj Chua
INTRODUCTION: Patients referred for chest pain from primary care have increased, along with demand for outpatient cardiology consultations. We evaluated 'Triage Protocol' that implements standardised diagnostic testing prior to patients' first cardiology consultation. MATERIALS AND METHODS: Under the 'Triage Protocol', patients referred for chest pain were pretriaged using a standardised algorithm and subsequently referred for relevant functional diagnostic cardiology tests before their initial cardiology consultation...
February 2018: Annals of the Academy of Medicine, Singapore
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