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https://www.readbyqxmd.com/read/28930197/red-blood-cell-eicosapentaenoic-acid-inversely-relates-to-mri-assessed-carotid-plaque-lipid-core-burden-in-elders-at-high-cardiovascular-risk
#1
Núria Bargalló, Rosa Gilabert, Edwin-Saúl Romero-Mamani, Montserrat Cofán, Philip C Calder, Montserrat Fitó, Dolores Corella, Jordi Salas-Salvadó, Miguel Ruiz-Canela, Ramon Estruch, Emilio Ros, Aleix Sala-Vila
Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2...
September 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28912100/influence-of-omega-3-fatty-acids-on-bovine-luteal-cell-plasma-membrane-dynamics
#2
Michele R Plewes, Patrick D Burns, Richard M Hyslop, B George Barisas
Fish oil is a rich source of omega-3 fatty acids which disrupt lipid microdomain structure and affect mobility of the prostaglandin F2α (FP) receptor in bovine luteal cells. The objectives of this study were to determine the effects of individual omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on 1) membrane fatty acid composition, 2) lipid microdomain structure, and 3) lateral mobility of the FP receptor in bovine luteal cells. Ovaries were collected from a local abattoir (n=5/experiment)...
September 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28900017/omega-3-fatty-acids-and-inflammatory-processes-from-molecules-to-man
#3
REVIEW
Philip C Calder
Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical mediators and interactions. The present article will describe nutritional and metabolic aspects of omega-6 (n-6) and omega-3 (n-3) fatty acids and explain the roles of bioactive members of those fatty acid families in inflammatory processes. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n-3 fatty acids found in oily fish and fish oil supplements...
September 12, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28887275/ffa4-gpr120-as-a-fatty-acid-sensor-involved-in-appetite-control-insulin-sensitivity-and-inflammation-regulation
#4
REVIEW
Dong-Soon Im
Unsaturated long-chain fatty acids have been suggested to be beneficial in the context of cardiovascular disorders based in epidemiologic studies conducted in Greenland and Mediterranean. DHA and EPA are omega-3 polyunsaturated fatty acids that are plentiful in fish oil, and oleic acid is an omega-9 monounsaturated fatty acid, rich in olive oil. Dietary intake of these unsaturated long-chain fatty acids have been associated with insulin sensitivity and weight loss, which contrasts with the impairment of insulin sensitivity and weight gain associated with high intakes of saturated long-chain fatty acids...
September 8, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28886129/modulation-of-the-endogenous-omega-3-fatty-acid-and-oxylipin-profile-in-vivo-a-comparison-of-the-fat-1-transgenic-mouse-with-c57bl-6-wildtype-mice-on-an-omega-3-fatty-acid-enriched-diet
#5
Annika I Ostermann, Patrick Waindok, Moritz J Schmidt, Cheng-Ying Chiu, Christopher Smyl, Nadine Rohwer, Karsten-H Weylandt, Nils Helge Schebb
Dietary intervention and genetic fat-1 mice are two models for the investigation of effects associated with omega-3 polyunsaturated fatty acids (n3-PUFA). In order to assess their power to modulate the fatty acid and oxylipin pattern, we thoroughly compared fat-1 and wild-type C57BL/6 mice on a sunflower oil diet with wild-type mice on the same diet enriched with 1% EPA and 1% DHA for 0, 7, 14, 30 and 45 days. Feeding led after 14-30 days to a high steady state of n3-PUFA in all tissues at the expense of n6-PUFAs...
2017: PloS One
https://www.readbyqxmd.com/read/28878301/epa-dha-6-1-prevents-angiotensin-ii-induced-hypertension-and-endothelial-dysfunction-in-rats-role-of-nadph-oxidase-and-cox-derived-oxidative-stress
#6
Zahid Rasul Niazi, Grazielle C Silva, Thais Porto Ribeiro, Antonio J León-González, Mohamad Kassem, Abdur Mirajkar, Azhar Alvi, Malak Abbas, Faraj Zgheel, Valérie B Schini-Kerth, Cyril Auger
Eicosapentaenoic acid:docosahexaenoic acid (EPA:DHA) 6:1, an omega-3 polyunsaturated fatty acid formulation, has been shown to induce a sustained formation of endothelial nitric oxide (NO) synthase-derived NO, a major vasoprotective factor. This study examined whether chronic intake of EPA:DHA 6:1 prevents hypertension and endothelial dysfunction induced by angiotensin II (Ang II) in rats. Male Wister rats received orally corn oil or EPA:DHA 6:1 (500 mg kg(-1) per day) before chronic infusion of Ang II (0...
September 7, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28870372/dha-and-epa-in-red-blood-cell-membranes-are-associated-with-dietary-intakes-of-omega-3-rich-fish-in-healthy-children
#7
Colleen A Parks, Neil R Brett, Sherry Agellon, Paula Lavery, Catherine A Vanstone, Jonathon L Maguire, Frank Rauch, Hope A Weiler
Omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) are important in child development. The primary objective of this study was to investigate the associations between dietary intakes of n-3 LCPUFA and red blood cell (RBC) n-3 LCPUFA in young children. Healthy children, (2-8y) underwent RBC fatty acid profiling. Dietary intakes were parent-reported over 6 mo using three 24h dietary intake assessments and three 30 d food frequency questionnaires (FFQ). Participants (n = 49, 5.6 ± 1.9y), were 59% male, and had a body mass index (BMI) z-score of 0...
September 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28869531/potential-application-of-eicosapentaenoic-acid-monoacylglyceride-in-the-management-of-colorectal-cancer
#8
Caroline Morin, Enrique Rodríguez, Pierre U Blier, Samuel Fortin
BACKGROUND: There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed. The goal of this study was to evaluate the anti-cancer effects of eicosapentaenoic acid monoglyceride (MAG-EPA) in HCT116 colorectal carcinoma cells. METHODS: The effect of MAG-EPA was evaluated in vitro on HCT116 cells and in vivo on mouse model of HCT116 xenograft...
September 4, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28859717/omega-3-index-and-obstructive-sleep-apnea-a-cross-sectional-study
#9
Janine Tittus, Marie Theres Huber, Klaus Storck, Anton Köhler, Jan M Köhler, Thomas von Arnim, Clemens von Schacky
STUDY OBJECTIVES: Erythrocyte levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (Omega-3 Index) were previously found to be associated with obstructive sleep apnea (OSA) at very low levels (< 5.0%) in only one epidemiologic study. OSA has comorbidities, such as arterial hypertension, heart failure, or major depression, also associated with a low Omega-3 Index. These comorbidities can be improved by increasing intake of EPA and DHA, and thus the Omega-3 Index, preferably to its target range of 8% to 11%...
August 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28857178/12-oh-17-18-epoxyeicosatetraenoic-acid-alleviates-eosinophilic-airway-inflammation-in-murine-lungs
#10
Takao Mochimaru, Koichi Fukunaga, Jun Miyata, Masako Matsusaka, Katsunori Masaki, Hiroki Kabata, Soichiro Ueda, Yusuke Suzuki, Tomomi Goto, Daisuke Urabe, Masayuki Inoue, Yosuke Isobe, Makoto Arita, Tomoko Betsuyaku
BACKGROUND: Asthma is characterized by airway inflammation and obstruction with eosinophil infiltration into the airway. Arachidonic acid, an omega-6 fatty acid, is metabolized into cysteinyl leukotriene with pro-inflammatory properties for allergic inflammation, whereas the omega-3 fatty acid eicosapentaenoic acid (EPA) and its downstream metabolites are known to have anti-inflammatory effects. In this study, we investigated the mechanism underlying the counter-regulatory roles of EPA in inflamed lungs...
August 30, 2017: Allergy
https://www.readbyqxmd.com/read/28839364/omega-3-fish-oil-reduces-mortality-due-to-severe-sepsis-with-acute-gastrointestinal-injury-grade-iii
#11
Huaisheng Chen, Wei Wang, Chengying Hong, Ming Zhang, Yingcai Hong, Su Wang, Huadong Zhang
BACKGROUND: Sepsis plays an important role in acute gastrointestinal injury (AGI). Our research was designed to determine the effects of omega-3 fish oil (FO) in patients suffering from severe sepsis combined with AGI III, and the ability of FO to modulate immune function. METHODS: Seventy-eight patients diagnosed with severe sepsis with AGI III and a need for mechanical ventilation were randomized to two groups. In the FO group, 50 g of long chain fatty acid soybean oil (n = 6) and 10 g of FO (n = 3) were administered as total parenteral nutrition (TPN)...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28838848/omega-3-polyunsaturated-fatty-acids-reduce-vascular-tone-and-inflammation-in-human-saphenous-vein
#12
Armond Daci, Gülsev Özen, İmran Uyar, Erkan Civelek, F İlkay Alp Yildirim, Deniz Kaleli Durman, Önder Teskin, Xavier Norel, B Sönmez Uydeş-Doğan, Gökce Topal
Dietary intake of omega-3 polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been reported to have beneficial cardiovascular effects. However, little is known about the effect of EPA and DHA on human vascular tone. Therefore, the aim of this study is to evaluate the effect of EPA and DHA on vascular tone of the human saphenous vein (SV) obtained from patients undergoing coronary bypass operation under normal and inflammatory conditions. Moreover, we aimed to investigate the effect of EPA and DHA on the release of inflammatory mediators from SV...
August 21, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28835852/degummed-crude-canola-oil-sire-breed-and-gender-effects-on-intramuscular-long-chain-omega-3-fatty-acid-properties-of-raw-and-cooked-lamb-meat
#13
Aaron Ross Flakemore, Bunmi Sherifat Malau-Aduli, Peter David Nichols, Aduli Enoch Othniel Malau-Aduli
BACKGROUND: Omega-3 long-chain (≥C20) polyunsaturated fatty acids (ω3 LC-PUFA) confer important attributes to health-conscious meat consumers due to the significant role they play in brain development, prevention of coronary heart disease, obesity and hypertension. In this study, the ω3 LC-PUFA content of raw and cooked Longissimus thoracis et lumborum (LTL) muscle from genetically divergent Australian prime lambs supplemented with dietary degummed crude canola oil (DCCO) was evaluated...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/28833063/metabolism-and-functions-of-docosahexaenoic-acid-containing-membrane-glycerophospholipids
#14
REVIEW
Daisuke Hishikawa, William J Valentine, Yoshiko Iizuka-Hishikawa, Hideo Shindou, Takao Shimizu
Omega-3 (ω-3) fatty acids (FAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to have important roles in human health and disease. Besides being utilized as fuel, ω-3 FAs have specific functions based on their structural characteristics. These functions include serving as ligands for several receptors, precursors of lipid mediators, and components of membrane glycerophospholipids (GPLs). Since ω-3 FAs (especially DHA) are highly flexible, the levels of DHA in GPLs may affect membrane biophysical properties such as fluidity, flexibility, and thickness...
August 21, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28831714/omega-3-fatty-acid-levels-in-red-blood-cell-membranes-and-physical-decline-over-3%C3%A2-years-longitudinal-data-from-the-mapt-study
#15
Bertrand Fougère, Sabine Goisser, Christelle Cantet, Gaëlle Soriano, Sophie Guyonnet, Philipe De Souto Barreto, Matteo Cesari, Sandrine Andrieu, Bruno Vellas
Studies have shown that omega-3 polyunsaturated fatty acids (PUFAs) are associated with brain, cardiovascular, and immune function, as well as physical performance and bone health in older adults. So far, few studies have investigated the associations between PUFA status and performance-based tests of physical function. The objective of this study was to investigate the associations between the omega-3 PUFA levels (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)) in red blood cell (RBC) membranes and physical performance, in a sample of community-dwelling older adults...
August 22, 2017: GeroScience
https://www.readbyqxmd.com/read/28830741/effects-of-omega-3-in-the-treatment-of-violent-schizophrenia-patients
#16
Yi Qiao, Yi Mei, Huiqin Han, FengJu Liu, Xiao Min Yang, Yang Shao, Bin Xie, Bin Long
OBJECTIVE: This study was designed to explore the relationship in between the daily consumption of fish oil (360mg DHA+540mg EPA), and reduction of symptoms and violent behavior among patients with schizophrenia. METHOD: Fifty inpatients meeting ICD-10 criteria for schizophrenia and scoring more than four of Modified Overt Aggression Scale (MOAS) with antipsychotics treatment were randomly assigned to receive either fish oil (N=28) or a placebo (N=22) in a twelve week, double-blind supplementation trial...
August 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28820441/genome-wide-interaction-study-of-omega-3-pufas-and-other-fatty-acids-on-inflammatory-biomarkers-of-cardiovascular-health-in-the-framingham-heart-study
#17
Jenna Veenstra, Anya Kalsbeek, Jason Westra, Craig Disselkoen, Caren Smith, Nathan Tintle
Numerous genetic loci have been identified as being associated with circulating fatty acid (FA) levels and/or inflammatory biomarkers of cardiovascular health (e.g., C-reactive protein). Recently, using red blood cell (RBC) FA data from the Framingham Offspring Study, we conducted a genome-wide association study of over 2.5 million single nucleotide polymorphisms (SNPs) and 22 RBC FAs (and associated ratios), including the four Omega-3 FAs (ALA, DHA, DPA, and EPA). Our analyses identified numerous causal loci...
August 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28804463/effect-of-oral-docosahexaenoic-acid-dha-supplementation-on-dha-levels-and-omega-3-index-in-red-blood-cell-membranes-of-breast-cancer-patients
#18
Alessio Molfino, Maria I Amabile, Sara Mazzucco, Gianni Biolo, Alessio Farcomeni, Cesarina Ramaccini, Simonetta Antonaroli, Massimo Monti, Maurizio Muscaritoli
Rationale: Docosahexaenoic acid (DHA) in cell membrane may influence breast cancer (BC) patients' prognosis, affecting tumor cells sensitivity to chemo- and radio-therapy and likely modulating inflammation. The possibility of identifying BC patients presenting with low DHA levels and/or low ability of DHA incorporation into cell membrane might help to treat this condition. Methods: We enrolled BC patients and healthy controls, recording their seafood dietary intake. DHA in form of algal oil was administered for 10 consecutive days (2 g/day)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28802571/omega-3-polyunsaturated-fatty-acids-improve-endothelial-function-in-humans-at-risk-for-atherosclerosis-a-review
#19
REVIEW
Kayla R Zehr, Mary K Walker
Epidemiology studies and clinical trials show that omega-3 polyunsaturated fatty acids (n-3 PUFAs) can prevent atherosclerotic morbidity and evidence suggests this may be mediated by improving endothelial dysfunction. Endothelial dysfunction is characterized by reduced vasodilation and a pro-inflammatory, pro-thrombotic state, and is an early pathological event in the development of atherosclerosis. Flow-mediated dilation (FMD), a gold standard for assessing endothelial dysfunction, is a predictor of future cardiovascular events and coronary heart disease risk...
August 9, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28800114/fatty-acid-profile-is-modulated-by-dietary-resveratrol-in-rainbow-trout-oncorhynchus-mykiss
#20
Claudia Torno, Stefanie Staats, Sonia de Pascual-Teresa, Gerald Rimbach, Carsten Schulz
To produce fish of a high quality that are rich in omega-3 fatty acids (n-3 FA) and simultaneously generate more sustainable aquaculture, the combined use of phytochemicals and vegetable oils in fish feed seems to be a promising approach. Resveratrol (RV) potentially induces endogenous fatty acid synthesis, resulting in elevated n-3 FA levels in fish. RV putatively influences ∆6-desaturase, the key enzyme in FA metabolism, and serves as a ligand for PPARα, a transcription factor regulating β-oxidation. Rainbow trout (36...
August 11, 2017: Marine Drugs
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