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https://www.readbyqxmd.com/read/27909409/3-5-3-triiodo-l-thyronine-and-3-5-diiodo-l-thyronine-affected-metabolic-pathways-in-liver-of-ldl-receptor-deficient-mice
#1
Maria Moreno, Elena Silvestri, Maria Coppola, Ira J Goldberg, Li-Shin Huang, Anna M Salzano, Fulvio D'Angelo, Joel R Ehrenkranz, Fernando Goglia
3,5,3'-triiodo-L-thyronine (T3) and 3,5-diiodo-L-thyronine (T2), when administered to a model of familial hypercholesterolemia, i.e., low density lipoprotein receptor (LDLr)-knockout (Ldlr(-/-)) mice fed with a Western type diet (WTD), dramatically reduce circulating total and very low-density lipoprotein/LDL cholesterol with decreased liver apolipoprotein B (ApoB) production. The aim of the study was to highlight putative molecular mechanisms to manage cholesterol levels in the absence of LDLr. A comprehensive comparative profiling of changes in expression of soluble proteins in livers from Ldlr(-/-) mice treated with either T3 or T2 was performed...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27854029/acute-administration-of-3-5-diiodo-l-thyronine-to-hypothyroid-rats-stimulates-bioenergetic-parameters-in-liver-mitochondria
#2
Alessandro Cavallo, Federica Taurino, Fabrizio Damiano, Luisa Siculella, Anna Maria Sardanelli, Antonio Gnoni
The role of 3,5-diiodo-L-thyronine (T2), initially considered only a 3,3',5-triiodo-L-thyronine (T3) catabolite, in the bioenergetic metabolism is of growing interest. In this study we investigated the acute effects (within 1 h) of T2 administration to hypothyroid rats on liver mitochondria fatty acid uptake and β-oxidation rate, mitochondrial efficiency (by measuring proton leak) and mitochondrial oxidative damage (by determining H2O2 release). Fatty acid uptake into mitochondria was measured assaying carnitine palmitoyl transferase (CPT) I and II activities, and fatty acid β-oxidation using palmitoyl-CoA as a respiratory substrate...
November 17, 2016: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/27793418/omega-3-fatty-acids-decreases-oxidative-stress-tumor-necrosis-factor-alpha-and-interleukin-1-beta-in-hyperthyroidism-induced-hepatic-dysfunction-rat-model
#3
Asmaa M S Gomaa, Ebtihal A Abd El-Aziz
Hyperthyroidism is associated with abnormalities of the liver. Omega-3 polyunsaturated fatty acids, especially their long-chain forms: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have beneficial health effects. The objectives of the present study were to assess hyperthyroidism-induced hepatic dysfunction in adult male rats and to evaluate the ameliorative effects of omega-3 on hyperthyroidism-induced hepatic dysfunction and the underlying mechanisms. Twenty four adult male rats were randomly divided into three equal groups; control group which received water for 6 weeks, hyperthyroid group which received L-thyroxine orally for 6 weeks and hyperthyroid omega-3 treated group which received L-thyroxine for 2 weeks and then co-treated with L-thyroxine and omega-3 oral compound containing 18% of EPA and 12% of DHA for 4 weeks...
December 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/27736670/refuse-leachate-exposure-causes-changes-of-thyroid-hormone-level-and-related-gene-expression-in-female-goldfish-carassius-auratus
#4
Yufeng Gong, Hua Tian, Xiaona Zhang, Yifei Dong, Wei Wang, Shaoguo Ru
To elucidate the potential thyroid disrupting effects of refuse leachate on females, female goldfish (Carassius auratus) were exposed to 0.5% diluted leachates from each step of a leachate treatment process (i.e. raw leachate before treatment, after membrane bioreactor treatment, and the final treated leachate) for 21days. Raw leachate exposure caused disturbances in the thyroid cascade of female fish, as evidenced by the elevated plasma 3,3',5-triiodo-l-thyronine (p<0.05) and thyroid-stimulating hormone (p<0...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27699652/insulin-like-growth-factor-1-regulation-of-proliferation-and-differentiation-of-xenopus-laevis-myogenic-cells-in-vitro
#5
Sairi Miyata, Tomotaka Yada, Natsuko Ishikawa, Kazi Taheruzzaman, Ryohei Hara, Takashi Matsuzaki, Akio Nishikawa
To understand the mechanism of muscle remodeling during Xenopus laevis metamorphosis, we examined the in vitro effect of insulin-like growth factor 1 (IGF-1) on growth and differentiation of three different-fate myogenic cell populations: tadpole tail, tadpole dorsal, and young adult leg muscle. IGF-1 promoted growth and differentiation of both tail and leg myogenic cells only under conditions where these cells could proliferate. Inhibition of cell proliferation by DNA synthesis inhibitor cytosine arabinoside completely canceled the IGF-1's cell differentiation promotion, suggesting the possibility that IGF-1's differentiation-promotion effect is an indirect effect via IGF-1's cell proliferation promotion...
October 3, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/27697637/possible-contributions-of-thyroid-hormone-replacement-to-specific-behaviors-of-cancer
#6
Aleck Hercbergs, Paul J Davis, Hung-Yun Lin, Shaker A Mousa
l-Thyroxine (T4) is the principal replacement hormone for patients who have hypothyroidism. Some preclinical and clinical evidence supports the possibility that T4 can at least permissively affect certain features of established cancers and cancer-relevant angiogenesis. Thus, in the occasional patient with hypothyroidism and concomitant cancer, it appears reasonable to consider thyroid hormone replacement exclusively with 3,3',5-triiodo-l-thyronine (T3). This use of T3 has been shown to be effective and safe in early experience with medical induction of euthyroid hypothyroxinemia in patients with advanced solid tumors...
September 30, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27649501/determination-of-thyroid-hormones-in-mouse-tissues-by-isotope-dilution-microflow-liquid-chromatography-mass-spectrometry-method
#7
Meri De Angelis, Florian Giesert, Brian Finan, Christoffer Clemmensen, Timo D Müller, Daniela Vogt-Weisenhorn, Matthias H Tschöp, Karl-Werner Schramm
Thyroid hormones (THs) play a critical role in the regulation of many biological processes such as growth, metabolism and development both in humans and wildlife. In general, TH levels are measured by immunoassay (IA) methods but the specificity of the antibodies used in these assays limits selectivity. In the last decade, several analytical methods using liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (LC-MS/MS) have been developed to measure THs. These new techniques proved to be more accurate than the IA analysis and they were widely used for the determination of TH level in different human and animal tissues...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27514733/in-vitro-differentiation-potential-of-human-haematopoietic-cd34-cells-towards-pancreatic-%C3%AE-cells
#8
Manne Mudhu Sunitha, Lokanathan Srikanth, Pasupuleti Santhosh Kumar, Chodimella Chandrasekhar, Potukuchi Venkata Gurunadha Krishna Sarma
Haematopoietic stem cells (HSCs) possess multipotent ability to differentiate into various types of cells on providing appropriate niche. In the present study, the differentiating potential of human HSCs into β-cells of islets of langerhans was explored. Human HSCs were apheretically isolated from a donor and cultured. Phenotypic characterization of CD34 glycoprotein in the growing monolayer HSCs was confirmed by immunocytochemistry and flow cytometry techniques. HSCs were induced by selection with beta cell differentiating medium (BDM), which consists of epidermal growth factor (EGF), fibroblast growth factor (FGF), transferrin, Triiodo-l-Tyronine, nicotinamide and activin A...
October 2016: Cell Biology International
https://www.readbyqxmd.com/read/27493972/actions-of-thyroid-hormone-analogues-on-chemokines
#9
REVIEW
Paul J Davis, Gennadi V Glinsky, Hung-Yun Lin, Shaker A Mousa
The extracellular domain of plasma membrane integrin αvβ3 contains a receptor for thyroid hormone (L-thyroxine, T4; 3,5,3'-triiodo-L-thyronine, T3); this receptor also binds tetraiodothyroacetic acid (tetrac), a derivative of T4. Tetrac inhibits the binding of T4 and T3 to the integrin. Fractalkine (CX3CL1) is a chemokine relevant to inflammatory processes in the CNS that are microglia-dependent but also important to normal brain development. Expression of the CX3CL1 gene is downregulated by tetrac, suggesting that T4 and T3 may stimulate fractalkine expression...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27477408/hyperthyroidism-improves-the-pathological-condition-of-nonalcoholic-steatohepatitis-a-case-of-nonalcoholic-steatohepatitis-with-graves-disease
#10
Teruki Miyake, Bunzo Matsuura, Shinya Furukawa, Yasuhiko Todo, Shin Yamamoto, Osamu Yoshida, Yusuke Imai, Takao Watanabe, Yasunori Yamamoto, Masashi Hirooka, Yoshio Tokumoto, Teru Kumagi, Masanori Abe, Hirotaka Seike, Shozo Miyauchi, Yoichi Hiasa
3,5,3'-triiodo-L-thyronine regulates the glucose metabolism, lipid metabolism, and hepatic steatosis. Several groups have shown the relationships between hypothyroidism and nonalcoholic fatty liver and hypothyroidism and nonalcoholic steatohepatitis (NASH). However, the effect of hyperthyroidism on NASH has not yet been investigated. We herein report effects of thyroid hormone on the pathological condition of NASH in a patient with NASH complicated by Graves' disease. In our case, the liver enzyme level improved with the increasing thyroid hormone level; however, the liver enzyme level was aggravated with the improving thyroid hormone level...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27458161/crosstalk-between-integrin-%C3%AE-v%C3%AE-3-and-er%C3%AE-contributes-to-thyroid-hormone-induced-proliferation-of-ovarian-cancer-cells
#11
Meng-Ti Hsieh, Le-Ming Wang, Chun A Changou, Yu-Tang Chin, Yu-Chen S H Yang, Hsuan-Yu Lai, Sheng-Yang Lee, Yung-Ning Yang, Jacqueline Whang-Peng, Leroy F Liu, Hung-Yun Lin, Shaker A Mousa, Paul J Davis
Ovarian cancer is the leading cause of death in gynecological diseases. Thyroid hormone promotes proliferation of ovarian cancer cells via cell surface receptor integrin αvβ3 that activates extracellular regulated kinase (ERK1/2). However, the mechanisms are still not fully understood. Thyroxine (T4) at a physiologic total hormone concentration (10-7 M) significantly increased proliferating cell nuclear antigen (PCNA) abundance in these cell lines, as did 3, 5, 3'-triiodo-L-thyronine (T3) at a supraphysiologic concentration...
July 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27381084/synthesis-of-mr-49-a-deiodinated-analog-of-tetraiodothyroacetic-acid-tetrac-as-a-novel-pro-angiogenesis-modulator
#12
Mehdi Rajabi, Thangirala Sudha, Noureldien H E Darwish, Paul J Davis, Shaker A Mousa
The tyrosine-based hormones 3,3',5-triiodo-l-thyronine (l-T3) and l-thyroxine (l-T4) that are produced by the thyroid gland control metabolic functions. Iodothyronine deiodinase enzymes convert l-T4 to l-T3, the form of thyroid hormone critical to genomic actions within cells and regulation of metabolism, and to reverse-l-T3, a hormone isoform that is largely inactive. We used tertiary amines in a study of deiodination based on derivatives of tetraiodothyroacetic acid (tetrac)-a naturally occurring derivative of l-T4-to mimic the action of the iodothyronine deiodinases and deiodination of the outer ring iodines...
August 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27351461/sequential-camouflage-of-the-arachno-6-9-c2b8h14-cage-by-substituents
#13
Mario Bakardjiev, Bohumil Štíbr, Josef Holub, Oleg L Tok, Petr Švec, Zdeňka Růžičková, Aleš Růžička
Sequential methylation of arachno-6,9-C2B8H14 (1) led to a series of methyl derivatives and finally to the camouflaging of all boron positions by mixed persubstitution. Thus, deprotonation of 1 produced the [arachno-6,9-C2B8H13] anion (1(-)), the methylation of which with MeI in tetrahydrofuran proceeded on the open-face boron vertexes with the formation of 5-Me-arachno-6,9-C2B8H13 (2; yield 28%) and 5,8-Me2-arachno-6,9-C2B8H12 (3; yield 36%). Observed in this reaction was also a side formation of 2-Me-closo-1,6-C2B8H9 (4; yield 6%)...
July 18, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27338438/comparison-of-individual-and-combined-effects-of-four-endocrine-disruptors-on-estrogen-receptor-beta-transcription-in-cerebellar-cell-culture-the-modulatory-role-of-estradiol-and-triiodo-thyronine
#14
Gergely Jocsak, David Sandor Kiss, Istvan Toth, Greta Goszleth, Tibor Bartha, Laszlo V Frenyo, Tamas L Horvath, Attila Zsarnovszky
BACKGROUND: Humans and animals are continuously exposed to a number of environmental substances that act as endocrine disruptors (EDs). While a growing body of evidence is available to prove their adverse health effects, very little is known about the consequences of simultaneous exposure to a combination of such chemicals; METHODS: Here, we used an in vitro model to demonstrate how exposure to bisphenol A, zearalenone, arsenic, and 4-methylbenzylidene camphor, alone or in combination, affect estrogen receptor β (ERβ) mRNA expression in primary cerebellar cell cultures...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27312083/effects-of-thyroxine-t4-3-5-3-triiodo-l-thyronine-t3-and-their-metabolites-on-osteoblast-differentiation
#15
Shaohong Cheng, Weirong Xing, Sheila Pourteymoor, Subburaman Mohan
Studies involving human genetic mutations and mutant mouse models have provided irrevocable evidence for a key role for thyroid hormones (THs) in the regulation of skeletal growth. While T3 binds to TH receptors with higher affinity than T4, T4 occupied TH receptors have also been reported in the nucleus under euthyroid conditions raising the possibility that T4 bound nuclear receptors may be biologically relevant in thyroid syndromes with elevated free T4 and reduced T3 levels. We, therefore, evaluated the direct effects of T4, T3, and their metabolites (rT3 and T2) in stimulating osteoblast differentiation using MC3T3-E1 preosteoblasts which do not produce detectable levels of deiodinases...
October 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27210270/hepatic-insulin-like-growth-factor-binding-protein-igfbp-responses-to-food-restriction-in-atlantic-salmon-smolts
#16
Jason P Breves, Silas K Phipps-Costin, Chelsea K Fujimoto, Ingibjörg E Einarsdottir, Amy M Regish, Björn Thrandur Björnsson, Stephen D McCormick
The growth hormone (Gh)/insulin-like growth-factor (Igf) system plays a central role in the regulation of growth in fishes. However, the roles of Igf binding proteins (Igfbps) in coordinating responses to food availability are unresolved, especially in anadromous fishes preparing for seaward migration. We assayed plasma Gh, Igf1, thyroid hormones and cortisol along with igfbp mRNA levels in fasted and fed Atlantic salmon (Salmo salar). Fish were fasted for 3 or 10days near the peak of smoltification (late April to early May)...
July 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27114094/maternal-body-burdens-of-pcdd-fs-and-pbdes-are-associated-with-maternal-serum-levels-of-thyroid-hormones-in-early-pregnancy-a-cross-sectional-study
#17
Sanna Lignell, Marie Aune, Per Ola Darnerud, Mats Stridsberg, Annika Hanberg, Susanna C Larsson, Anders Glynn
BACKGROUND: Thyroid hormones (THs) regulate many biological functions in the human body and are essential for normal brain development. Epidemiological studies have observed diverging associations between halogenated persistent organic pollutant (POP) exposure and concentrations of THs in pregnant women and their infants. We investigated whether background exposure to polybrominated diphenyl ethers (PBDEs) is related to TH status in a Swedish population of pregnant women and their infants...
April 26, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27094730/theoretical-insight-into-the-sensitive-mechanism-of-multilayer-shaped-cocrystal-explosives-compression-and-slide
#18
Hong-fei Gao, Shu-hai Zhang, Fu-de Ren, Rui-jun Gou, Gang Han, Jing-bo Wu, Xiong Ding, Wen-hu Zhao
Multilayer-shaped compression and slide models were employed to investigate the complex sensitive mechanisms of cocrystal explosives in response to external mechanical stimuli. Here, density functional theory (DFT) calculations implementing the generalized gradient approximation (GGA) of Perdew-Burke-Ernzerhof (PBE) with the Tkatchenko-Scheffler (TS) dispersion correction were applied to a series of cocrystal explosives: diacetone diperoxide (DADP)/1,3,5-trichloro-2,4,6-trinitrobenzene (TCTNB), DADP/1,3,5-tribromo-2,4,6-trinitrobenzene (TBTNB) and DADP/1,3,5-triiodo-2,4,6-trinitrobenzene (TITNB)...
May 2016: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/26981865/safe-oral-triiodo-l-thyronine-therapy-protects-from-post-infarct-cardiac-dysfunction-and-arrhythmias-without-cardiovascular-adverse-effects
#19
Viswanathan Rajagopalan, Youhua Zhang, Kaie Ojamaa, Yue-Feng Chen, Alessandro Pingitore, Christine J Pol, Debra Saunders, Krithika Balasubramanian, Rheal A Towner, A Martin Gerdes
BACKGROUND: A large body of evidence suggests that thyroid hormones (THs) are beneficial for the treatment of cardiovascular disorders. We have shown that 3 days of triiodo-L-thyronine (T3) treatment in myocardial infarction (MI) rats increased left ventricular (LV) contractility and decreased myocyte apoptosis. However, no clinically translatable protocol is established for T3 treatment of ischemic heart disease. We hypothesized that low-dose oral T3 will offer safe therapeutic benefits in MI...
2016: PloS One
https://www.readbyqxmd.com/read/26963519/thyroid-active-agents-t3-and-ptu-differentially-affect-immune-gene-transcripts-in-the-head-kidney-of-rainbow-trout-oncorynchus-mykiss
#20
Alba Quesada-García, Paloma Encinas, Ana Valdehita, Lisa Baumann, Helmut Segner, Julio M Coll, José M Navas
In mammals, numerous reports describe an immunomodulating effect of thyroid-active compounds. In contrast, only few reports have been published on this subject in fish. We previously demonstrated that immune cells of rainbow trout (Oncorhynchus mykiss) possess thyroid hormone receptors (THRs) and that exposure of trout to the thyroid hormone 3,3',5-triiodo-l-thyronine (T3) or the antithyroid drug propylthiouracil (PTU) alters immune cell transcript levels of THR and several immune genes. The present study aims to further characterize the immunomodulating action of thyroid-active compounds in trout immune cells...
May 2016: Aquatic Toxicology
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