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https://www.readbyqxmd.com/read/29125479/plasma-3-3-5-triiodo-l-thyronine-t3-level-mirrors-changes-in-tumor-markers-in-two-cases-of-metastatic-cancer-of-the-breast-and-pancreas-treated-with-exogenous-l-t3
#1
Alejandro Rodríguez-Molinero, Aleck Hercbergs, Manuel Sarrias, Antonio Yuste
Preclinical studies have attributed 3,3',5-triiodo-L-thyronine (T3) a direct negative effect on tumor progression, as well as chemosensitizing, differentiating and immunomodulatory properties. On the other hand, L-thyroxine (T4), via a thyroid hormone receptor on plasma membrane integrin αvβ3, promotes solid tumor growth and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth rate. We present the case of two patients with metastatic triple negative breast cancer and metastatic pancreatic cancer respectively, who benefit of the sole treatment with antithyroid drugs and exogenous administration of T3 (liothyronine)...
November 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29067001/culture-in-glucose-depleted-medium-supplemented-with-fatty-acid-and-3-3-5-triiodo-l-thyronine-facilitates-purification-and-maturation-of-human-pluripotent-stem-cell-derived-cardiomyocytes
#2
Bin Lin, Xianming Lin, Maxine Stachel, Elisha Wang, Yumei Luo, Joshua Lader, Xiaofang Sun, Mario Delmar, Lei Bu
With recent advances in stem cell technology, it is becoming efficient to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes, which can subsequently be used for myriad purposes, ranging from interrogating mechanisms of cardiovascular disease, developing novel cellular therapeutic approaches, as well as assessing the cardiac safety profile of compounds. However, the relative inability to acquire abundant pure and mature cardiomyocytes still hinders these applications. Recently, it was reported that glucose-depleted culture medium supplemented with lactate can facilitate purification of hPSC-derived cardiomyocytes...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29018054/the-induction-of-myeloma-cell-death-and-dna-damage-by-tetrac-a-thyroid-hormone-derivative
#3
Keren Cohen, Uri Abadi, Aleck Hercbergs, Paul J Davis, Martin Ellis, Osnat Ashur-Fabian
Multiple myeloma (MM) is a plasma cell malignancy in which involvement of the thyroid hormone-integrin αvβ3 pathway was shown and pharmacologic inhibition of this pathway is a rational approach to disease management. A thyroid hormone derivative, tetraiodothyroacetic acid (tetrac), which inhibits L-thyroxine (T4) and 3,5,3'-triiodo-L-thyronine (T3) binding to αvβ3 integrin, was studied in five MM cell lines and primary bone marrow (BM) MM cells. Tetrac inhibited MM cell proliferation (absolute cell number/viability) and induced caspase-dependent apoptosis (annexin-V/PI and cell cycle)...
October 10, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28974554/thyroid-and-glucocorticoid-hormones-promote-functional-t-tubule-development-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#4
Shan S Parikh, Daniel J Blackwell, Nieves Gomez-Hurtado, Michael Frisk, Lili Wang, Kyungsoo Kim, Christen P Dahl, Arnt E Fiane, Theis Tønnessen, Dmytro O Kryshtal, William E Louch, Bjorn C Knollmann
Rationale: Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) are increasingly being used for modeling heart disease and are under development for regeneration of the injured heart. However, incomplete structural and functional maturation of hiPSC-CM including lack of t-tubules, immature excitation-contraction (EC) coupling, and inefficient Ca-induced Ca release (CICR) remain major limitations. Objective: Thyroid and glucocorticoid hormones are critical for heart maturation. We hypothesized that their addition to standard protocols would promote t-tubule development and mature EC coupling of hiPSC-CM when cultured on extracellular matrix with physiological stiffness (Matrigel mattress)...
October 2, 2017: Circulation Research
https://www.readbyqxmd.com/read/28959215/both-3-5-diiodo-l-thyronine-and-3-5-3-triiodo-l-thyronine-prevent-short-term-hepatic-lipid-accumulation-via-distinct-mechanisms-in-rats-being-fed-a-high-fat-diet
#5
Rosalba Senese, Federica Cioffi, Pieter de Lange, Cristina Leanza, Liliana F Iannucci, Elena Silvestri, Maria Moreno, Assunta Lombardi, Fernando Goglia, Antonia Lanni
3,3',5-triiodo-L-thyronine (T3) improves hepatic lipid accumulation by increasing lipid catabolism but it also increases lipogenesis, which at first glance appears contradictory. Recent studies have shown that 3,5-diiodothyronine (T2), a natural thyroid hormone derivative, also has the capacity to stimulate hepatic lipid catabolism, however, little is known about its possible effects on lipogenic gene expression. Because genes classically involved in hepatic lipogenesis such as SPOT14, acetyl-CoA-carboxylase (ACC), and fatty acid synthase (FAS) contain thyroid hormone response elements (TREs), we studied their transcriptional regulation, focusing on TRE-mediated effects of T3 compared to T2 in rats receiving high-fat diet (HFD) for 1 week...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28950476/molecular-dynamics-approach-for-studying-the-nonequilibrium-behavior-of-x-ray-heated-solid-density-matter
#6
Malik Muhammad Abdullah, Anurag, Zoltan Jurek, Sang-Kil Son, Robin Santra
When matter is exposed to a high-intensity x-ray free-electron-laser pulse, the x rays excite inner-shell electrons leading to the ionization of the electrons through various atomic processes and creating high-energy-density plasma, i.e., warm or hot dense matter. The resulting system consists of atoms in various electronic configurations, thermalizing on subpicosecond to picosecond timescales after photoexcitation. We present a simulation study of x-ray-heated solid-density matter. For this we use XMDYN, a Monte Carlo molecular-dynamics-based code with periodic boundary conditions, which allows one to investigate nonequilibrium dynamics...
August 2017: Physical Review. E
https://www.readbyqxmd.com/read/28912375/organ-culture-of-the-xenopus-tadpole-intestine
#7
Atsuko Ishizuya-Oka
During Xenopus metamorphosis, most tadpole organs remodel from the larval to adult form to prepare for adaptation to terrestrial life. Organ culture serves as an important tool for studying larval-to-adult organ remodeling independent of the effects of other parts of the body. Here, I introduce a protocol for organ culture in vitro using the Xenopus laevis tadpole intestine before metamorphic climax. During culture in the absence of exogenous 3,3',5-triiodo-l-thyronine (T3), the most potent natural thyroid hormone, the intestine remains in its larval state without any metamorphic changes...
September 14, 2017: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/28891089/molecular-insights-into-the-transcriptional-regulatory-role-of-thyroid-hormones-in-ovarian-cancer
#8
Elena Shinderman-Maman, Chen Weingarten, Dotan Moskovich, Haim Werner, Aleck Hercbergs, Paul J Davis, Martin Ellis, Osnat Ashur-Fabian
The regulation of cancer-relevant genes by the thyroid hormones, 3, 5, 3'-Triiodo-L-thyronine (T3) and L-thyroxine (T4), was recently acknowledged. However, limited data exists on the hormonal effects on gene expression in ovarian cancer, a gynecological malignancy associated with a low cure rate. The expression of fifteen genes involved in DNA repair, cell cycle, apoptosis, and tumor suppression was evaluated in OVCAR-3 and A2780 cell lines, using real-time PCR following short incubation with T3 (1 nM) or T4 (100 nM)...
September 11, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28705270/serum-fetuin-a-levels-and-thyroid-function-inmiddle-aged-and-elderly-chinese
#9
Xin Ru Deng, Lin Ding, Tian Ge Wang, Min Xu, Jie Li Lu, Mian Li, Zhi Yun Zhao, Yu Hong Chen, Yu Fang Bi, Yi Ping Xu, Yu Xu
Serum fetuin-A levels are reportedly elevated in hyperthyroidism. However, there are few relevant epidemiologic studies. We conducted a cross-sectional study in Songnan community, China in 2009 to investigate the association between serum fetuin-A concentrations and thyroid function. A total of 2,984 participants aged 40 years and older were analyzed. Multivariable linear regression analysis revealed that serum fetuin-A concentra- tions were positively associated with log (free triiodothyronine) and were inversely associated with log (thyroid peroxidase antibody) after adjustment (both P < 0...
June 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28635586/gc-1-a-thyromimetic-with-multiple-therapeutic-applications-in-liver-disease
#10
Amedeo Columbano, Grazia Chiellini, Marta Anna Kowalik
Thyroid hormones, namely 3,5,3'-triiodo-L-thyronine (T3) and 3,5,3',5'-tetraiodo-L-thyronine (thyroxine or T4), influence a variety of physiological processes that have important implications in fetal development, metabolism, cell growth and proliferation. While THs elicit several beneficial effects on lipid metabolism and improve myocardial contractility, these therapeutically desirable effects are associated to a thyrotoxic state, that severely limits the possible use of THs as therapeutic agents. Therefore, several efforts have been made to develop T3 analogues that could retain the beneficial actions (triglyceride, cholesterol, obesity and body mass lowering), without the adverse TH-dependent side effects...
June 13, 2017: Gene Expression
https://www.readbyqxmd.com/read/28536504/thyroid-hormone-induces-pgc-1%C3%AE-during-dendritic-outgrowth-in-mouse-cerebellar-purkinje-cells
#11
Tetsu Hatsukano, Junko Kurisu, Kansai Fukumitsu, Kazuto Fujishima, Mineko Kengaku
Thyroid hormone 3,3',5-Triiodo-L-thyronine (T3) is essential for proper brain development. Perinatal loss of T3 causes severe growth defects in neurons and glia, including strong inhibition of dendrite formation in Purkinje cells in the cerebellar cortex. Here we show that T3 promotes dendritic outgrowth of Purkinje cells through induction of peroxisome proliferator-activated receptor gamma (PPARγ) co-activator 1α (PGC-1α), a master regulator of mitochondrial biogenesis. PGC-1α expression in Purkinje cells is upregulated during dendritic outgrowth in normal mice, while it is significantly retarded in hypothyroid mice or in cultures depleted of T3...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28446882/modified-low-dose-triiodo-l-thyronine-therapy-safely-improves-function-following-myocardial-ischemia-reperfusion-injury
#12
Viswanathan Rajagopalan, Youhua Zhang, Christine Pol, Clifford Costello, Samantha Seitter, Ann Lehto, Olga V Savinova, Yue-Feng Chen, A Martin Gerdes
Background: We have shown that thyroid hormones (THs) are cardioprotective and can be potentially used as safe therapeutic agents for diabetic cardiomyopathy and permanent infarction. However, no reliable, clinically translatable protocol exists for TH treatment of myocardial ischemia-reperfusion (IR) injury. We hypothesized that modified low-dose triiodo-L-thyronine (T3) therapy would confer safe therapeutic benefits against IR injury. Methods: Adult female rats underwent left coronary artery ligation for 60 min or sham surgeries...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28362337/action-of-thyroid-hormones-t3-and-t2-on-hepatic-fatty-acids-differences-in-metabolic-effects-and-molecular-mechanisms
#13
REVIEW
Fabrizio Damiano, Alessio Rochira, Antonio Gnoni, Luisa Siculella
The thyroid hormones (THs) 3,3',5,5'-tetraiodo-l-thyronine (T4) and 3,5,3'-triiodo-l-thyronine (T3) influence many metabolic pathways. The major physiological function of THs is to sustain basal energy expenditure, by acting primarily on carbohydrate and lipid catabolism. Beyond the mobilization and degradation of lipids, at the hepatic level THs stimulate the de novo fatty acid synthesis (de novo lipogenesis, DNL), through both the modulation of gene expression and the rapid activation of cell signalling pathways...
March 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28242306/characteristics-of-the-brown-hagfish-paramyxine-atami-transthyretin-metal-ion-dependent-thyroid-hormone-binding
#14
Shunsuke Suzuki, Kentaro Kasai, Norihito Nishiyama, Akinori Ishihara, Kiyoshi Yamauchi
Transthyretin (TTR) is a vertebrate-specific protein involved in thyroid hormone distribution in plasma, and its gene is thought to have emerged by gene duplication from the gene for the ancient TTR-related protein, 5-hydroxyisourate hydrolase, at some early stage of chordate evolution. We investigated the molecular and hormone-binding properties of the brown hagfish Paramyxine atami TTR. The amino acid sequence deduced from the cloned hagfish TTR cDNA shared 33-50% identities with those of other vertebrate TTRs but less than 24% identities with those of vertebrate and deuterostome invertebrate 5-hydroxyisourate hydrolases...
August 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28153800/avoiding-the-pitfalls-when-quantifying-thyroid-hormones-and-their-metabolites-using-mass-spectrometric-methods-the-role-of-quality-assurance
#15
REVIEW
Keith Richards, Eddy Rijntjes, Daniel Rathmann, Josef Köhrle
This short review aims to assess the application of basic quality assurance (QA) principles in published thyroid hormone bioanalytical methods using mass spectrometry (MS). The use of tandem MS, in particular linked to liquid chromatography has become an essential bioanalytical tool for the thyroid hormone research community. Although basic research laboratories do not usually work within the constraints of a quality management system and regulated environment, all of the reviewed publications, to a lesser or greater extent, document the application of QA principles to the MS methods described...
January 31, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28012382/a-validated-lc-ms-ms-method-for-thyroid-hormone-determination-in-sea-lamprey-petromyzon-marinus-plasma-gill-kidney-and-liver
#16
Ugo Bussy, Yu-Wen Chung-Davidson, Ke Li, Skye D Fissette, Ethan G Buchinger, Weiming Li
A UPLC-MS/MS method was developed to provide a reproducible, sensitive and quantitative assay to determine thyroid hormones in sea lamprey tissues and plasma. l-Thyroxine (T4) and its two triiodo-thyronine isomers have been simultaneously quantified and validated for plasma, gill, liver, and kidney matrices. Multiple sample preparation techniques were investigated to achieve optimal sample matrix digestion and clean-up. Enzymatic digestion followed by protein precipitation was selected to process the samples...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27909409/3-5-3-triiodo-l-thyronine-and-3-5-diiodo-l-thyronine-affected-metabolic-pathways-in-liver-of-ldl-receptor-deficient-mice
#17
Maria Moreno, Elena Silvestri, Maria Coppola, Ira J Goldberg, Li-Shin Huang, Anna M Salzano, Fulvio D'Angelo, Joel R Ehrenkranz, Fernando Goglia
3,5,3'-triiodo-L-thyronine (T3) and 3,5-diiodo-L-thyronine (T2), when administered to a model of familial hypercholesterolemia, i.e., low density lipoprotein receptor (LDLr)-knockout (Ldlr(-/-)) mice fed with a Western type diet (WTD), dramatically reduce circulating total and very low-density lipoprotein/LDL cholesterol with decreased liver apolipoprotein B (ApoB) production. The aim of the study was to highlight putative molecular mechanisms to manage cholesterol levels in the absence of LDLr. A comprehensive comparative profiling of changes in expression of soluble proteins in livers from Ldlr(-/-) mice treated with either T3 or T2 was performed...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27854029/acute-administration-of-3-5-diiodo-l-thyronine-to-hypothyroid-rats-stimulates-bioenergetic-parameters-in-liver-mitochondria
#18
Alessandro Cavallo, Federica Taurino, Fabrizio Damiano, Luisa Siculella, Anna Maria Sardanelli, Antonio Gnoni
The role of 3,5-diiodo-L-thyronine (T2), initially considered only a 3,3',5-triiodo-L-thyronine (T3) catabolite, in the bioenergetic metabolism is of growing interest. In this study we investigated the acute effects (within 1 h) of T2 administration to hypothyroid rats on liver mitochondria fatty acid uptake and β-oxidation rate, mitochondrial efficiency (by measuring proton leak) and mitochondrial oxidative damage (by determining H2O2 release). Fatty acid uptake into mitochondria was measured assaying carnitine palmitoyl transferase (CPT) I and II activities, and fatty acid β-oxidation using palmitoyl-CoA as a respiratory substrate...
October 2016: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/27793418/omega-3-fatty-acids-decreases-oxidative-stress-tumor-necrosis-factor-alpha-and-interleukin-1-beta-in-hyperthyroidism-induced-hepatic-dysfunction-rat-model
#19
Asmaa M S Gomaa, Ebtihal A Abd El-Aziz
Hyperthyroidism is associated with abnormalities of the liver. Omega-3 polyunsaturated fatty acids, especially their long-chain forms: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have beneficial health effects. The objectives of the present study were to assess hyperthyroidism-induced hepatic dysfunction in adult male rats and to evaluate the ameliorative effects of omega-3 on hyperthyroidism-induced hepatic dysfunction and the underlying mechanisms. Twenty four adult male rats were randomly divided into three equal groups; control group which received water for 6 weeks, hyperthyroid group which received L-thyroxine orally for 6 weeks and hyperthyroid omega-3 treated group which received L-thyroxine for 2 weeks and then co-treated with L-thyroxine and omega-3 oral compound containing 18% of EPA and 12% of DHA for 4 weeks...
December 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/27736670/refuse-leachate-exposure-causes-changes-of-thyroid-hormone-level-and-related-gene-expression-in-female-goldfish-carassius-auratus
#20
Yufeng Gong, Hua Tian, Xiaona Zhang, Yifei Dong, Wei Wang, Shaoguo Ru
To elucidate the potential thyroid disrupting effects of refuse leachate on females, female goldfish (Carassius auratus) were exposed to 0.5% diluted leachates from each step of a leachate treatment process (i.e. raw leachate before treatment, after membrane bioreactor treatment, and the final treated leachate) for 21days. Raw leachate exposure caused disturbances in the thyroid cascade of female fish, as evidenced by the elevated plasma 3,3',5-triiodo-l-thyronine (p<0.05) and thyroid-stimulating hormone (p<0...
December 2016: Environmental Toxicology and Pharmacology
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