keyword
https://read.qxmd.com/read/37987394/the-antihypertensive-guanabenz-exacerbates-integrated-stress-response-and-disrupts-the-brain-circadian-clock
#21
JOURNAL ARTICLE
Hao Lin, Muhammad Naveed, Aidan Hansen, Tracy G Anthony, Ruifeng Cao
The circadian clock regulates a variety of biological processes that are normally synchronized with the solar day. Disruption of circadian rhythms is associated with health problems. Understanding the signaling mechanisms that couple cell physiology and metabolism to circadian timekeeping will help to develop novel therapeutic strategies. The integrated stress response (ISR) is activated by the cellular stressors to maintain physiological homeostasis by orchestrating mRNA translation. Aberrant ISR has been found in a number of neurological diseases that exhibit disrupted circadian rhythms and sleep...
October 31, 2023: Clocks & Sleep
https://read.qxmd.com/read/37978857/relational-skill-training-for-patient-engagement-and-the-creation-of-a-trauma-informed-critical-care
#22
JOURNAL ARTICLE
Laura Istanboulian, Tasneem Master, Christine Devine, Lorrie Hamilton
Patients and families in critical care have a high likelihood of previous and re-experienced trauma. Unaddressed, physical, and psychological impacts of these traumas can worsen outcomes for patients and families. A trauma-informed care approach has been proposed for critical care; however, training programs do not include relational competencies or de-escalation techniques, risking the re-traumatization of patients and families in critical care and negatively impacting clinicians. This article describes a strategy that can be adopted by critical care teams towards the creation of a trauma-informed critical care unit including the use of a framework for relational training...
November 18, 2023: Healthcare Management Forum
https://read.qxmd.com/read/37971741/ranking-decision-making-criteria-for-early-adoption-of-innovative-surgical-technologies
#23
JOURNAL ARTICLE
Haitham Shoman, Nisha D Almeida, Michael Tanzer
IMPORTANCE: There is no decision-making framework in the early-adoption stage of novel surgical technologies, putting the quality of health care and resource allocation of the health care system at risk. OBJECTIVE: To investigate relevant weighted criteria that decision-makers may use to make an informed decision for the early adoption of innovative surgical technologies. DESIGN, SETTING, AND PARTICIPANTS: This multi-institutional decision analytical modeling study used a mixed-methods multicriteria decision analysis (MCDA) and had 2 phases...
November 1, 2023: JAMA Network Open
https://read.qxmd.com/read/37885423/allan-william-cripps-a-mucosal-immunologist-and-mentor-from-beginning-to-end
#24
JOURNAL ARTICLE
Maree Gleeson, Nicholas P West
Allan Cripps was internationally recognized in the field of mucosal immunology, in particular the relationship between respiratory diseases and mucosal immunization strategies. Allan's career spanned scientific and applied research, commercialization, health education, and evolved into leadership roles in public-health and academic administration. Allan published over 400 papers and mentored over 40 research higher degree candidates. Allan was renowned for his mentorship, that did not end with the awarding of a PhD or Master's degree, but continued across a lifetime of professional engagement...
October 27, 2023: Immunology and Cell Biology
https://read.qxmd.com/read/37850791/understanding-pathways-to-health-system-pharmacy-administration-a-journey-mapping-study
#25
JOURNAL ARTICLE
Jacqueline E McLaughlin, Kathryn A Morbitzer, Jacqueline M Zeeman, Stephen F Eckel
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: Pharmacy administrators play a critical role in the success of health systems, yet pathways to pharmacy administration are incompletely understood...
October 18, 2023: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/37792436/tumor-agnostic-approvals-insights-and-practical-considerations
#26
JOURNAL ARTICLE
Chengxing Cindy Lu, Robert A Beckman, Xiaoyun Nicole Li, Weidong Zhang, Qi Jiang, Olga Marchenko, Zhiping Sun, Hong Tian, Jingjing Ye, Shuai Sammy Yuan, Godwin Yung
Since the first approval of a tumor-agnostic indication in 2017, a total of seven tumor-agnostic indications involving six drugs have received approval from the US Food and Drug Administration. In this paper, the master protocol subteam of the Statistical Methods in Oncology Scientific Working Group, Biopharmaceutical Session, American Statistical Association, provides a comprehensive summary of these seven tumor-agnostic approvals, describing their mechanisms of action; biomarker prevalence; study design; companion diagnostics; regulatory aspects, including comparisons of global regulatory requirements; and Health Technology Assessment approval...
October 4, 2023: Clinical Cancer Research
https://read.qxmd.com/read/37767205/when-science-meets-entrepreneurship
#27
JOURNAL ARTICLE
Dara Satrio, Vanessa Rijkeboer, Angelica Reitsma, Edo Roos Lindgreen, Katja C Wolthers, Dasja Pajkrt
Science industries, such as the health and medical industry, are experiencing increases in competition regarding commercializing, patenting, and funding of scientific outputs. As such, scientists are facing increased expectation to engage in academic entrepreneurship. OrganoVIR (Organoids for Virus Research) is a Horizon2020 Innovative Training Network (ITN) that aims to train Early Stage Researchers (ESRs) to lead innovation in the field of human organoids for virus research. To assist them in this process, OrganoVIR introduced a pre-Master of Business Administration program that introduced OrganoVIR's ESRs to the tools and knowledge necessary to navigate the competitive industry...
2023: Open Res Eur
https://read.qxmd.com/read/37672970/-it-s-not-just-about-the-numbers-inside-the-black-box-of-nurses-professional-judgement-in-nurse-staffing-systems-in-england-and-wales-insights-from-a-qualitative-cross-case-comparative-study
#28
JOURNAL ARTICLE
Davina Allen, Nina Jacob, Heather Strange, Aled Jones, Chris Burton, Anne Marie Rafferty
BACKGROUND: Whether implicit or explicit, professional judgement is a central component of the many nurse staffing systems implemented in high-income countries to inform workforce planning and staff deployment. Whilst a substantial body of research has evaluated the technical and operational elements of nurse staffing systems, no studies have systematically examined the role of professional judgement and its contribution to decision-making. OBJECTIVE: To explore nurses' use of professional judgement in nurse staffing systems in England and Wales...
August 11, 2023: International Journal of Nursing Studies
https://read.qxmd.com/read/37643228/nursing-faculty-workforce-development-project
#29
JOURNAL ARTICLE
Susan Welch, Kristi Acker, Wanda Burton, Michelle Cheshire, Andrea Sartain, Monika Wedgeworth, Teresa Welch
A proposed nursing faculty workforce development project by a college of nursing within a research-intensive institution will increase the number of nurse faculty from the current population of BSN-prepared nurses from underserved communities in a state to earn a master of science in nursing (MSN) degree with a nursing education specialty. This project will be accomplished through partnerships between a college of nursing and academic institutions with large nursing student populations from underserved communities...
October 2023: Nursing Administration Quarterly
https://read.qxmd.com/read/37640441/automation-of-the-medication-process-in-swiss-hospitals-results-of-a-survey
#30
JOURNAL ARTICLE
Edith Hufschmid Thurnherr, Hendrike Dahmke, Pierre Voirol, Brigitte Waldispühl Suter, Monika Lutters, Priska Vonbach
OBJECTIVES: Medication management is a core process in hospital administration. The safety, timeliness and efficiency of medication distribution may be improved by automating logistical and administrative aspects of the process. Forming an accurate high-level picture of current practices may help decision-makers to better advance the state of automation. This study aims to identify which systems for automating the medication process are currently in use in Swiss hospitals, and to what extent each system is used...
August 27, 2023: European Journal of Hospital Pharmacy. Science and Practice
https://read.qxmd.com/read/37610749/sociodemographic-differences-in-covid-19-pandemic-experiences-among-families-in-the-united-states
#31
JOURNAL ARTICLE
Kaja Z LeWinn, Leonardo Trasande, Andrew Law, Courtney K Blackwell, Traci A Bekelman, Jessica A Arizaga, Alexis A Sullivan, Theresa M Bastain, Carrie V Breton, Margaret R Karagas, Amy J Elliott, Catherine J Karr, Kecia N Carroll, Anne L Dunlop, Lisa A Croen, Amy E Margolis, Akram N Alshawabkeh, Jose F Cordero, Anne Marie Singh, Christine M Seroogy, Daniel J Jackson, Robert A Wood, Tina V Hartert, Young Shin Kim, Cristiane S Duarte, Julie B Schweitzer, Barry M Lester, Cynthia T McEvoy, Thomas G O'Connor, Emily Oken, Nicole Bornkamp, Eric D Brown, Christina A Porucznik, Assiamira Ferrara, Carlos A Camargo, Qi Zhao, Jody M Ganiban, Lisa P Jacobson
IMPORTANCE: Few population-based studies in the US collected individual-level data from families during the COVID-19 pandemic. OBJECTIVE: To examine differences in COVID-19 pandemic-related experiences in a large sociodemographically diverse sample of children and caregivers. DESIGN, SETTING, AND PARTICIPANTS: The Environmental influences on Child Health Outcomes (ECHO) multi-cohort consortium is an ongoing study that brings together 64 individual cohorts with participants (24 757 children and 31 700 caregivers in this study) in all 50 US states and Puerto Rico...
August 1, 2023: JAMA Network Open
https://read.qxmd.com/read/37591501/public-open-spaces-and-leisure-time-walking-a-longitudinal-study-with-brazilian-people-in-the-covid-19-pandemic
#32
JOURNAL ARTICLE
Alex Antonio Florindo, Bianca Mitie Onita, Margarethe Thaisi Garro Knebel, Rildo de Souza Wanderley Júnior, Inaian Pignatti Teixeira, Gavin Turrell
AIM: To examine whether changes in public open spaces (POS) were associated with leisure-time walking (LTW) between 2014 and 2021. METHODS: The sample comprised a prospective cohort of individuals living in São Paulo City, Brazil. The baseline sample was collected in 2014/2015 (4042 people aged 12 y or older) and the second wave in 2020/2021 (1431 people aged 18 y or older, 35.4% of total). Changes in POS scores in 500-m network buffers were based on household address, including positive or negative maintenance and increases or decreases in parks, public squares, and bike paths between 2015 and 2020...
August 17, 2023: Journal of Physical Activity & Health
https://read.qxmd.com/read/37531549/global-health-postgraduate-educational-programs-profile-a-scoping-review
#33
JOURNAL ARTICLE
Camilla Porto Campello, Liliane Botelho Antunes Menezes, Mara Rúbia André Alves de Lima, Acácio Sidinei Almeida Santos, Paulo Marchiori Buss
This study aimed to describe a set of global health postgraduate programs profile, emphasizing the importance of promoting education and training in this field to meet global health challenges and ameliorate health outcomes. The present review is in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews (PRISMA-ScR) checklist and the Scoping Review Methods Manual proposed by the Joanna Briggs Institute. Eligibility criteria were a set of lato sensu or stricto sensu postgraduate educational programs of global health or lato sensu or stricto sensu postgraduate programs of public health that present a global health concentration area...
August 2023: Ciência & Saúde Coletiva
https://read.qxmd.com/read/37473539/in-utero-and-childhood-exposure-to-alcohol-and-old-age-mortality-evidence-from-the-temperance-movement-in-the-us
#34
JOURNAL ARTICLE
Hamid Noghanibehambari, Jason Fletcher
Previous research suggests the relevance of in-utero insults and early-life circumstances for a wide array of life cycle outcomes. This research note joins this strand of studies by exploring the long-run mortality effects of in-utero and early-life exposure to alcohol accessibility. In so doing, we take advantage of the prohibition movement during the early part of the twentieth century that generated quasi-natural reductions in alcohol consumption. We use Social Security Administration Death Master Files linked to the full-count 1940 census and compare the longevity of male individuals exposed to the prohibition during in-utero and early childhood (1900-1930) as a result of statewide and federal alcohol ban to those wet counties after the law change to before...
July 14, 2023: Economics and Human Biology
https://read.qxmd.com/read/37466076/covid-19-health-education-activities-an-analysis-of-a-national-sample-of-certified-health-educations-specialists-ches-%C3%A2-mches-%C3%A2-in-response-to-the-global-pandemic
#35
JOURNAL ARTICLE
Beth H Chaney, Michael L Stellefson, Melissa Opp, Marianne Allard, J Don Chaney, Kylie Lovett
The National Commission of Health Education Credentialing, Inc. (NCHEC) created the Category 1 COVID-19 Claim Form Opportunity to document how Certified Health Education Specialists (CHES® ) and Master Certified Health Education Specialists (MCHES® ) assisted communities during the COVID-19 pandemic. Using data submitted by CHES® /MCHES® ( n = 3,098 claim forms), the purpose of this study was to (a) describe the settings where CHES® and MCHES® completed their pandemic work and (b) assess differences in the type of pandemic work completed by CHES® compared with MCHES® based on specific Areas of Responsibility (AOR) for Health Education Specialists...
July 19, 2023: Health Promotion Practice
https://read.qxmd.com/read/37356821/assessing-the-validity-of-race-and-ethnicity-coding-in-administrative-medicare-data-for-reporting-outcomes-among-medicare-advantage-beneficiaries-from-2015-to-2017
#36
JOURNAL ARTICLE
Andrew W Huang, David J Meyers
OBJECTIVE: To assess the validity of race/ethnicity coding in Medicare data and whether misclassification errors lead to biased outcome reporting by race/ethnicity among Medicare Advantage beneficiaries. DATA SOURCES AND STUDY SETTING: In this national study of Medicare Advantage beneficiaries, we analyzed individual-level data from the Health Outcomes Survey (HOS) and the Consumer Assessment of Healthcare Providers and Systems (CAHPS), race/ethnicity codes from the Medicare Master Beneficiary Summary File (MBSF), and outcomes from the Medicare Provider Analysis and Review (MedPAR) files from 2015 to 2017...
June 25, 2023: Health Services Research
https://read.qxmd.com/read/37340429/continuing-professional-development-cpd-training-needs-assessment-for-medical-laboratory-professionals-in-ethiopia
#37
JOURNAL ARTICLE
Endale Hadgu Gebregzabher, Firehiwot Tesfaye, Waqtola Cheneke, Abebe Edao Negesso, Gizachew Kedida
BACKGROUND: Continuing professional development (CPD) is required for health workers in practice to update knowledge and skills regularly to match the changing complexity of healthcare needs. The objective of this study was to identify the training needs of Medical Laboratory professionals in Ethiopia. METHODS: A total of 457 medical laboratory professionals from five regions and two city administrations were involved in the study. Data were collected from August 02 to 21, 2021 with structured self-administered online tool with five-point Likert scale...
June 20, 2023: Human Resources for Health
https://read.qxmd.com/read/37305428/eribulin-mesylate-induces-bone-mass-loss-by-promoting-osteoclastic-bone-resorption-in-mice
#38
JOURNAL ARTICLE
Takahiro Ishizaka, Keisuke Horiuchi, Shinya Kondo, Masashi Isaji, Takahiro Nakagawa, Masahiro Inoue, Hajime Rikitake, Eiko Taguchi, Michiro Susa, Masaki Yoda, Takeshi Ono, Yusuke Kozai, Kazuhiro Chiba
Over the past few decades, the clinical outcomes of patients with cancer have significantly improved mostly owing to the development of effective chemotherapeutic treatments. However, chronic health conditions such as bone mass loss and risk of fragility fractures caused by chemotherapy have also emerged as crucial issues in patients treated for cancer. In this study, we aimed to understand the effect of eribulin mesylate (ERI), a microtubule-targeting agent currently used to treat metastatic breast cancer and certain subtypes of advanced sarcomas, on bone metabolism in mice...
June 2023: Bone Reports
https://read.qxmd.com/read/37286491/-current-issues-related-to-education-in-the-five-core-disciplines-of-public-health-at-the-school-of-public-health-in-a-private-university
#39
JOURNAL ARTICLE
Keisuke Kuwahara, Satoru Kanamori, Asuka Suzuki, Katsuhiko Shibuya, Mio Kato, Yoshiharu Fukuda, Mariko Inoue
Objectives In Japan, schools of public health (SPH) have engaged in professional education focusing on five core disciplines: epidemiology, biostatistics, social and behavioral science, health policy and management, and occupational and environmental health. However, empirical information is lacking regarding the current state of this education and its associated challenges in Japan. In this article, we showcase this issue, using the master of public health (MPH) course at Teikyo University Graduate School of Public Health (Teikyo SPH) as an example...
June 8, 2023: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://read.qxmd.com/read/37271661/interprofessional-education-tracks-one-schools-response-to-common-ipe-barriers
#40
JOURNAL ARTICLE
Kim G Adcock, Sally Earl
BACKGROUND: Implementing meaningful interprofessional education (IPE) experiences into the curriculum often requires overcoming barriers and challenges. To overcome these challenges on a non-medical center campus, school of pharmacy IPE faculty implemented a longitudinal, three-semester, multi-track series. The goals of forming a multi-track series were: (1) to overcome the pharmacy class size compared to the other available disciplines, (2) to utilize disciplines available on a liberal arts campus, and (3) to address varying academic calendars between disciplines...
June 2, 2023: Currents in Pharmacy Teaching & Learning
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