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Julien Pichette, Audrey Laurence, Leticia Angulo, Frederic Lesage, Alain Bouthillier, Dang Khoa Nguyen, Frederic Leblond
Using light, we are able to visualize the hemodynamic behavior of the brain to better understand neurovascular coupling and cerebral metabolism. In vivo optical imaging of tissue using endogenous chromophores necessitates spectroscopic detection to ensure molecular specificity as well as sufficiently high imaging speed and signal-to-noise ratio, to allow dynamic physiological changes to be captured, isolated, and used as surrogate of pathophysiological processes. An optical imaging system is introduced using a 16-bands on-chip hyperspectral camera...
October 2016: Neurophotonics
Jay Pan, Hanqing Zhao, Xiuli Wang, Xun Shi
In 2009, the Chinese government launched a new round of healthcare reform, which encourages development of private hospitals. Meanwhile, many public hospitals in China also became increasingly profit-oriented. These trends have led to concerns about social justice and regional disparity. However, there is a lack of empirical scientific analysis to support the debate. We started to fill this gap by conducting a regional-level analysis of spatial variation in spatial access to hospitals in the Sichuan Province...
October 1, 2016: Social Science & Medicine
Irene Estévez, Victor Sopo, Angel Lizana, Alex Turpin, Juan Campos
We propose a new complete snapshot Stokes polarimeter based on a single biaxial crystal. It presents different strengths (snapshot, complete polarimetric measurements, large data redundancy, and high sensitivity) in a simple and compact optical arrangement. The polarimeter is experimentally implemented and analyzed in terms of accuracy and repeatability.
October 1, 2016: Optics Letters
Josep M Llibre, Alessandro Cozzi-Lepri, Court Pedersen, Matti Ristola, Marcelo Losso, Amanda Mocroft, Viktar Mitsura, Karolin Falconer, Fernando Maltez, Marek Beniowski, Vincenzo Vullo, Gamal Hassoun, Elena Kuzovatova, János Szlavik, Anastasiia Kuznetsova, Hans-Jürgen Stellbrink, Claudine Duvivier, Simon Edwards, Kamilla Laut, Roger Paredes
Effectiveness data of an unboosted atazanavir (ATV) with abacavir/lamivudine (ABC/3TC) switch strategy in clinical routine are scant.We evaluated treatment outcomes of ATV + ABC/3TC in pretreated subjects in the EuroSIDA cohort when started with undetectable plasma HIV-1 viral load (pVL), performing a time to loss of virological response (TLOVR <50 copies/mL) and a snapshot analysis at 48, 96, and 144 weeks. Virological failure (VF) was defined as confirmed pVL >50 copies/mL.We included 285 subjects, 67% male, with median baseline CD4 530 cells, and 44 months with pVL ≤50 copies/mL...
October 2016: Medicine (Baltimore)
Zhi Wang, Ravithree Senanayake, Christine M Aikens, Wen-Miao Chen, Chen-Ho Tung, Di Sun
Here we report the single-crystal structure, experimental and theoretical characterization of a 41-metal atom Au-Ag alloy nanocluster [Au3Ag38(SCH2Ph)24X5](2-) (1, X = Cl or Br). The nanocluster 1 is co-protected by thiolate and halogen atoms and features an all-metallic face-fused biicosahedral Au2@AuAg20 rod-like kernel enwrapped by the outermost Ag18(SCH2Ph)24X3 shell. Two sites on the surface of the biicosahedral kernel are partially occupied by Au and Ag atoms. The outer Ag18(SCH2Ph)24X3 shell is composed of two Ag6S6 cycles at the two poles and one Ag6S2X3 arc at the equator with both 2- and 3-coordinated Ag atoms, which has not been observed in gold or silver nanoclusters ever before...
October 17, 2016: Nanoscale
Wook-Jin Chae, Alfred L M Bothwell
No abstract text is available yet for this article.
September 2016: Journal of Thoracic Disease
Thomas H Hartranft, Kurt Yandle, Tim Graham, Charles Holden, Lowell W Chambers
OBJECTIVE: This study was conducted to assess the effectiveness of a newly implemented electronic web-based review system created at our institution for evaluating resident performance relative to established milestones. DESIGN: Retrospective review of data collected from a survey of general surgery faculty and residents. SETTING: Tertiary care teaching hospital system and independent academic medical center. PARTICIPANTS: A total of 12 general surgery faculty and 17 general surgery residents participated in this study...
October 13, 2016: Journal of Surgical Education
Basil H Aboul-Enein, Joshua Bernstein, Jacquelyn E Bowser
There is a positive association between availability of regional peer-reviewed public health information systems and progressive change in community and population health. The objective of this brief report was to identify public health journals in Arabic-speaking countries actively publishing as of 2016. We conducted an electronic search in several electronic database records for public health journals using a combination of search terms. We excluded journals that focused on human medicine, veterinary medicine, nursing, and other discipline-specific or clinical health professions...
October 14, 2016: Journal of Public Health Policy
Otília Menyhárt, Hajnalka Harami-Papp, Saraswati Sukumar, Reinhold Schäfer, Luca Magnani, Oriol de Barrios, Balázs Győrffy
The hallmarks of cancer capture the most essential phenotypic characteristics of malignant transformation and progression. Although numerous factors involved in this multi-step process are still unknown to date, an ever-increasing number of mutated/altered candidate genes are being identified within large-scale cancer genomic projects. Therefore, investigators need to be aware of available and appropriate techniques capable of determining characteristic features of each hallmark. We review the methods tailored to experimental cancer researchers to evaluate cell proliferation, programmed cell death, replicative immortality, induction of angiogenesis, invasion and metastasis, genome instability, and reprogramming of energy metabolism...
October 11, 2016: Biochimica et Biophysica Acta
Alexey Petrushin, Lorenzo Ferrara, Axel Blau
OBJECTIVE: In light of recent progress in mapping neural function to behavior, we briefly and selectively review past and present endeavors to reveal and reconstruct nervous system function in Caenorhabditis elegans through simulation. APPROACH: Rather than presenting an all-encompassing review on the mathematical modeling of C. elegans, this contribution collects snapshots of pathfinding key works and emerging technologies that recent single- and multi-center simulation initiatives are building on...
October 14, 2016: Journal of Neural Engineering
Tia Renouf, Megan Pollard
Rural and remote places like Sable Island (Nova Scotia) or François (Newfoundland) pose a challenge in delivering both health care and appropriate education that today's learners need to practice in a rural setting. This education can be difficult to deliver to students far from academic centers. This is especially true for learners and practitioners at offshore locations like ships, oil installations, or in the air when patients are transported via fixed wing aircraft or helicopter. The following editorial provides a snapshot of the setting and the challenges faced while working as a physician on a ship, in remote regions...
September 9, 2016: Curēus
David A Moskowitz, Michael E Roloff
Research on gay and bisexual men's sexual position self-label (i.e., being a top, bottom, or versatile during anal sex) has revealed only independent snapshots of its development by focusing primarily on the influence of penis size. Moreover, the basic chronology of development of the sexual position self-label has barely been addressed. In response, we implemented a survey of 282 gay and bisexual men that measured demographics (including height and penis size), age of sexual recognitions, sexual position self-label, and attitudinal constructs suggested by previous literature as important (e...
October 12, 2016: Archives of Sexual Behavior
Jessica A Cardin
γ oscillations (20-80 Hz) are associated with sensory processing, cognition, and memory, and focused attention in animals and humans. γ activity can arise from several neural mechanisms in the cortex and hippocampus and can vary across circuits, behavioral states, and developmental stages. γ oscillations are nonstationary, typically occurring in short bouts, and the peak frequency of this rhythm is modulated by stimulus parameters. In addition, the participation of excitatory and inhibitory neurons in the γ rhythm varies across local circuits and conditions, particularly in the cortex...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Huyen-Thi Tran, Seon-Hwa Lee, Thien-Hoang Ho, Seung-Hye Hong, Kim-Hung Huynh, Yeh-Jin Ahn, Deok-Kun Oh, Lin-Woo Kang
The fructose 1,6-bisphosphate aldolase (FBA) is important for both glycolysis and gluconeogenesis in life. Class II (zinc dependent) FBA is an attractive target for the development of antibiotics against protozoa, bacteria, and fungi and also widely used to produce various high-value stereoisomers in the chemical and pharmaceutical industry. In this study, crystal structures of class II Escherichia coli FBA (EcFBA) were determined from four different crystals with resolutions between 1.8 Å and 2.0 Å. Native EcFBA structures showed two separate sites of Zn1 (interior position) and Zn2 (active site surface position) for Zn2+ ion...
October 13, 2016: BMB Reports
Daniel Petras, Louis-Félix Nothias, Robert A Quinn, Theodore Alexandrov, Nuno Bandeira, Amina Bouslimani, Gabriel Castro-Falcón, Liangyu Chen, Tam Dang, Dimitrios J Floros, Vivian Y H Hook, Neha Garg, Nicole Hoffner, Yike Jiang, Clifford A Kapono, Irina Koester, Rob Knight, Christopher A Leber, Tiejun Ling, Tal Luzzatto-Knaan, Laura-Isobel McCall, Aaron Philip McGrath, Michael J Meehan, Jonathan K Merritt, Robert H Mills, Jamie Morton, Sonia Podvin, Ivan Protsyuk, Trevor Purdy, Kendall Satterfield, Stephen Searles, Sahil Shah, Sarah Shires, Dana Steffen, Margot White, Jelena Todoric, Robert Tuttle, Aneta Wojnicz, Valerie Sapp, Fernando Vargas, Jin Yang, Chao Zhang, Pieter C Dorrestein
The cars we drive, the homes we live in, the restaurants we visit, and the labs and offices we work in are all a part of the modern human habitat. Remarkably, little is known about the diversity of chemicals present in these environments and to what degree molecules from our bodies influence the built environment that surrounds us and vice versa. We therefore set out to visualize the chemical diversity of five built human habitats together with their occupants, to provide a snapshot of the various molecules to which humans are exposed on a daily basis...
October 12, 2016: Analytical Chemistry
Richard B Lipton, Sagar Munjal, Dawn C Buse, Kristina M Fanning, Alix Bennett, Michael L Reed
BACKGROUND: Pain freedom at 2 hours and sustained pain response at 24 hours are important outcomes of acute migraine therapy. Some studies have examined rates and predictors of successful treatment outcomes for single attacks in clinical trials. However, little is known about predictors of typical response to acute treatment over multiple attacks in the population. OBJECTIVES: To identify sociodemographic features, headache characteristics, comorbidities and treatment-related factors that predict acute treatment success or failure at 2 hours and 24 hours post dose in a US population sample of persons with episodic migraine...
October 12, 2016: Headache
Qiuyan Li, Yuandong Qiao, Guangfa Zhang, Ning He, Xuelong Zhang, Xueyuan Jia, Haiming Sun, Chuntao Wang, Lidan Xu
Men who have sex with men (MSM) are at high risk of HIV infection. The APOBEC3G (apolipoprotein B mRNA editing catalytic polypeptide 3G) protein is a component of innate antiviral immunity that inhibits HIV-1 replication. In the present study, a total of 483 HIV-1 seropositive men and 493 HIV-1 seronegative men were selected to investigate the association between single nucleotide polymorphisms (SNPs) of the APOBEC3G gene and susceptibility to HIV-1 infection and AIDS progression among MSM residing in northern China...
October 11, 2016: Archives of Virology
Than J Boves, Graham D Fairhurst, Clark S Rushing, David A Buehler
In migratory species, breeding and non-breeding locations are geographically separate, yet the effects of conditions from one stage may carry over to affect a subsequent stage. Ideally, to understand the mechanisms and implications of 'carry-over effects', one would need to follow individuals throughout the year, quantify potential environmental causal factors and physiological mediators during multiple life-history stages, and measure downstream fitness. Owing to current limitations of tracking technology, this is impossible for small, long-distance migrants, so indirect methods to characterize carry-over effects are required...
2016: Conservation Physiology
Jessica I Rivera-Perez, Tasha M Santiago-Rodriguez, Gary A Toranzos
Paleomicrobiology, or the study of ancient microorganisms, has raised both fascination and skepticism for many years. While paleomicrobiology is not a recent field, the application of emerging techniques, such as DNA sequencing, is proving essential and has provided novel information regarding the evolution of viruses, antibiotic resistance, saprophytes, and pathogens, as well as ancient health and disease status, cultural customs, ethnic diets, and historical events. In this review, we highlight the importance of studying ancient microbial DNA, its contributions to current knowledge, and the role that forensic paleomicrobiology has played in deciphering historical enigmas...
August 2016: Microbiology Spectrum
Emilie Strady, Vu Bich Hanh Dang, Julien Némery, Stéphane Guédron, Quoc Tuc Dinh, Hervé Denis, Phuoc Dan Nguyen
The Saigon River, Southern Vietnam, crosses one of the most dynamic developing Megacity in Southeast Asia: Ho Chi Minh City (HCMC). The increased economic, industrial, and domestic developments may affect the environmental quality of water and halieutic resources. In this study, we evaluated the seasonal (dry and wet seasons) biogeochemical state of the Saigon River during two snapshot campaigns conducted along the river basin upstream from HCMC; the Saigon River was characterized by slightly acidic (pH 5.7-7...
October 10, 2016: Environmental Science and Pollution Research International
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