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https://www.readbyqxmd.com/read/28225448/predicting-hcahps-scores-from-hospitals-social-media-pages-a-sentiment-analysis
#1
John W Huppertz, Peter Otto
BACKGROUND: Social media is an important communication channel that can help hospitals and consumers obtain feedback about quality of care. However, despite the potential value of insight from consumers who post comments about hospital care on social media, there has been little empirical research on the relationship between patients' anecdotal feedback and formal measures of patient experience. PURPOSE: The aim of the study was to test the association between informal feedback posted in the Reviews section of hospitals' Facebook pages and scores on two global items from the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, Overall Hospital Rating and Willingness to Recommend the Hospital...
February 22, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28212972/variation-in-health-technology-assessment-and-reimbursement-processes-in-europe
#2
Ronald L Akehurst, Eric Abadie, Noël Renaudin, François Sarkozy
BACKGROUND: It has been suggested that differences in health technology assessment (HTA) processes among countries, particularly within Europe, have led to inequity in patient access to new medicines. OBJECTIVES: To provide an up-to-date snapshot analysis of the present status of HTA and reimbursement systems in select European countries, and to investigate the implications of these processes, especially with regard to delays in market and patient access. METHODS: HTA and reimbursement processes were assessed through a review of published and gray literature, and through a series of interviews with HTA experts...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28173627/genetic-architecture-and-balancing-selection-the-life-and-death-of-differentiated-variants
#3
Violaine Llaurens, Annabel Whibley, Mathieu Joron
Balancing selection describes any form of natural selection which results in the persistence of multiple variants of a trait at intermediate frequencies within populations. By offering up a snapshot of multiple co-occurring functional variants and their interactions, systems under balancing selection can reveal the evolutionary mechanisms favouring the emergence and persistence of adaptive variation in natural populations. We here focus on the mechanisms by which several functional variants for a given trait can arise, a process typically requiring multiple epistatic mutations...
February 7, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28119267/forensic-snp-genotyping-with-snapshot-technical-considerations-for-the-development-and-optimization-of-multiplexed-snp-assays
#4
REVIEW
M Fondevila, C Børsting, C Phillips, M de la Puente, Euroforen-NoE Consortium, A Carracedo, N Morling, M V Lareu
This review explores the key factors that influence the optimization, routine use, and profile interpretation of the SNaPshot single-base extension (SBE) system applied to forensic single-nucleotide polymorphism (SNP) genotyping. Despite being a mainly complimentary DNA genotyping technique to routine STR profiling, use of SNaPshot is an important part of the development of SNP sets for a wide range of forensic applications with these markers, from genotyping highly degraded DNA with very short amplicons to the introduction of SNPs to ascertain the ancestry and physical characteristics of an unidentified contact trace donor...
January 2017: Forensic Science Review
https://www.readbyqxmd.com/read/28078793/insights-into-nuclear-dynamics-using-live-cell-imaging-approaches
#5
REVIEW
Rachel B Bigley, Alexander Y Payumo, Jeffrey M Alexander, Guo N Huang
The nucleus contains the genetic blueprint of the cell and myriad interactions within this subcellular structure are required for gene regulation. In the current scientific era, characterization of these gene regulatory networks through biochemical techniques coupled with systems-wide 'omic' approaches has become commonplace. However, these strategies are limited because they represent a mere snapshot of the cellular state. To obtain a holistic understanding of nuclear dynamics, relevant molecules must be studied in their native contexts in living systems...
March 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/27940518/radial-spokes-a-snapshot-of-the-motility-regulation-assembly-and-evolution-of-cilia-and-flagella
#6
Xiaoyan Zhu, Yi Liu, Pinfen Yang
Propulsive forces generated by cilia and flagella are used in events that are critical for the thriving of diverse eukaryotic organisms in their environments. Despite distinctive strokes and regulations, the majority of them adopt the 9+2 axoneme that is believed to exist in the last eukaryotic common ancestor. Only a few outliers have opted for a simpler format that forsakes the signature radial spokes and the central pair apparatus, although both are unnecessary for force generation or rhythmicity. Extensive evidence has shown that they operate as an integral system for motility control...
December 9, 2016: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/27782430/perspective-kohn-sham-density-functional-theory-descending-a-staircase
#7
Haoyu S Yu, Shaohong L Li, Donald G Truhlar
This article presents a perspective on Kohn-Sham density functional theory (KS-DFT) for electronic structure calculations in chemical physics. This theory is in widespread use for applications to both molecules and solids. We pay special attention to several aspects where there are both concerns and progress toward solutions. These include: 1. The treatment of open-shell and inherently multiconfigurational systems (the latter are often called multireference systems and are variously classified as having strong correlation, near-degeneracy correlation, or high static correlation; KS-DFT must treat these systems with broken-symmetry determinants)...
October 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27767345/bayer-filter-snapshot-hyperspectral-fundus-camera-for-human-retinal-imaging
#8
Joel Kaluzny, Hao Li, Wenzhong Liu, Peter Nesper, Justin Park, Hao F Zhang, Amani A Fawzi
PURPOSE: To demonstrate the versatility and performance of a compact Bayer filter snapshot hyperspectral fundus camera for in-vivo clinical applications including retinal oximetry and macular pigment optical density measurements. METHODS: 12 healthy volunteers were recruited under an Institutional Review Board (IRB) approved protocol. Fundus images were taken with a custom hyperspectral camera with a spectral range of 460-630 nm. We determined retinal vascular oxygen saturation (sO2) for the healthy population using the captured spectra by least squares curve fitting...
October 21, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27746056/evaluating-surgical-residents-quickly-and-easily-against-the-milestones-using-electronic-formative-feedback
#9
Thomas H Hartranft, Kurt Yandle, Tim Graham, Charles Holden, Lowell W Chambers
OBJECTIVE: This study was conducted to assess the effectiveness of a newly implemented electronic web-based review system created at our institution for evaluating resident performance relative to established milestones. DESIGN: Retrospective review of data collected from a survey of general surgery faculty and residents. SETTING: Tertiary care teaching hospital system and independent academic medical center. PARTICIPANTS: A total of 12 general surgery faculty and 17 general surgery residents participated in this study...
October 13, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27742921/peer-reviewed-public-health-journals-from-arabic-speaking-countries-an-updated-snapshot
#10
Basil H Aboul-Enein, Joshua Bernstein, Jacquelyn E Bowser
There is a positive association between availability of regional peer-reviewed public health information systems and progressive change in community and population health. The objective of this brief report was to identify public health journals in Arabic-speaking countries actively publishing as of 2016. We conducted an electronic search in several electronic database records for public health journals using a combination of search terms. We excluded journals that focused on human medicine, veterinary medicine, nursing, and other discipline-specific or clinical health professions...
October 14, 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/27739402/the-si-elegans-project-at-the-interface-of-experimental-and-computational-caenorhabditis-elegans-neurobiology-and-behavior
#11
Alexey Petrushin, Lorenzo Ferrara, Axel Blau
OBJECTIVE: In light of recent progress in mapping neural function to behavior, we briefly and selectively review past and present endeavors to reveal and reconstruct nervous system function in Caenorhabditis elegans through simulation. APPROACH: Rather than presenting an all-encompassing review on the mathematical modeling of C. elegans, this contribution collects snapshots of pathfinding key works and emerging technologies that recent single- and multi-center simulation initiatives are building on...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27712893/two-years-in-igf-research
#12
REVIEW
Briony E Forbes
The last two years of insulin-like growth factor (IGF) research has yielded a vast literature highlighting the central role IGFs factors play in processes such as development, growth, aging and neurological function. It also provides our latest understanding of how IGF system perturbation is linked to diseases including growth deficiency, cancer, and neurological and cardiovascular diseases. A snapshot of the highlights is presented in this review, focussing on the topics of IGFs and growth, comparative and structural biology to understand insulin-like peptide function, IGFs and cancer, and IGFs and neurological function...
October 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27601632/axoneme-structure-from-motile-cilia
#13
REVIEW
Takashi Ishikawa
The axoneme is the main extracellular part of cilia and flagella in eukaryotes. It consists of a microtubule cytoskeleton, which normally comprises nine doublets. In motile cilia, dynein ATPase motor proteins generate sliding motions between adjacent microtubules, which are integrated into a well-orchestrated beating or rotational motion. In primary cilia, there are a number of sensory proteins functioning on membranes surrounding the axoneme. In both cases, as the study of proteomics has elucidated, hundreds of proteins exist in this compartmentalized biomolecular system...
January 3, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/27583669/development-of-the-respiratory-tract-microbiota-in-cystic-fibrosis
#14
Emma M de Koff, Karin M de Winter – de Groot, Debby Bogaert
PURPOSE OF REVIEW: Progression of lung disease in cystic fibrosis (CF) is punctuated by Pseudomonas aeruginosa infection and recurrent pulmonary exacerbations, and is the major determinant of a patient's life expectancy. With the advent of novel deep-sequencing techniques, polymicrobial bacterial assemblages rather than single pathogens seem to be responsible for the deterioration of pulmonary function. This review summarizes recent insights into the development of the CF respiratory tract microbiome, with its determinants and its relations to clinical parameters...
November 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27549026/the-inflammatory-role-of-phagocyte-apoptotic-pathways-in-rheumatic-diseases
#15
REVIEW
Carla M Cuda, Richard M Pope, Harris Perlman
Rheumatoid arthritis affects nearly 1% of the world's population and is a debilitating autoimmune condition that can result in joint destruction. During the past decade, inflammatory functions have been described for signalling molecules classically involved in apoptotic and non-apoptotic death pathways, including, but not limited to, Toll-like receptor signalling, inflammasome activation, cytokine production, macrophage polarization and antigen citrullination. In light of these remarkable advances in the understanding of inflammatory mechanisms of the death machinery, this Review provides a snapshot of the available evidence implicating death pathways, especially within the phagocyte populations of the innate immune system, in the perpetuation of rheumatoid arthritis and other rheumatic diseases...
August 23, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27499328/molecular-and-structural-basis-of-low-interfacial-energy-of-complex-coacervates-in-water
#16
REVIEW
YongSeok Jho, Hee Young Yoo, Yanxian Lin, Songi Han, Dong Soo Hwang
Complex coacervate refers to a phase-separated fluid, typically of two oppositely charged polyelectrolytes in solution, representing a complex fluid system that has been shown to be of essential interest to biological systems, as well as for soft materials processing owing to the expectation of superior underwater coating or adhesion properties. The significance and interest in complex coacervate fluids critically rely on its low interfacial tension with respect to water that, in turn, facilitates the wetting of macromolecular or material surfaces under aqueous conditions, provided there is attractive interaction between the polyelectrolyte constituents and the surface...
January 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/27448694/coevolution-of-parasitic-fungi-and-insect-hosts
#17
REVIEW
Gerrit Joop, Andreas Vilcinskas
Parasitic fungi and their insect hosts provide an intriguing model system for dissecting the complex co-evolutionary processes, which result in Red Queen dynamics. To explore the genetic basis behind host-parasite coevolution we chose two parasitic fungi (Beauveria bassiana and Metarhizium anisopliae, representing the most important entomopathogenic fungi used in the biological control of pest or vector insects) and two established insect model hosts (the greater wax moth Galleria mellonella and the red flour beetle Tribolium castaneum) for which sequenced genomes or comprehensive transcriptomes are available...
August 2016: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/27444598/review-of-never-and-serious-events-related-to-dentistry-2005-2014
#18
T Renton, W Sabbah
Aims To review never and serious events related to dentistry between 2005-2014 in England.Methods Data from the National Reporting and Learning System (NRLS), with agreed data protection and intelligence governance, was used - snapshot view using the timeframe January 2005 to May 2014. The Strategic Executive Information System (STEIS) database was reported separately for 2012-2013 and 2013-2014. The free text elements from the database were analysed thematically and reclassified according to the nature of the patient safety incident (PSI)...
July 22, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27350887/mammographic-parenchymal-patterns-and-breast-cancer-risk-in-new-south-wales-north-coast-aboriginal-and-torres-strait-islander-women
#19
Ruth Pape, Kelly Maree Spuur, Geoffrey Currie, Lacey Greene
INTRODUCTION: The objective of the study was to document the distribution of mammographic parenchymal patterns (MPP) of Indigenous Australian women attending BreastScreen New South Wales (NSW) North Coast, to profile breast cancer risk as it relates to breast density and to explore the correlation between MPP, breast size as described by the posterior nipple line (PNL) and age. METHODS: Ethics was granted from CQUniversity Human Research Ethics Committee, NSW Population Health Services Research Ethics Committee and the Aboriginal Health and Medical Research Council Ethics Committee...
June 2016: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27303926/molecular-and-genetic-inflammation-networks-in-major-human-diseases
#20
REVIEW
Yongzhong Zhao, Christian V Forst, Camil E Sayegh, I-Ming Wang, Xia Yang, Bin Zhang
It has been well-recognized that inflammation alongside tissue repair and damage maintaining tissue homeostasis determines the initiation and progression of complex diseases. Albeit with the accomplishment of having captured the most critical inflammation-involved molecules, genetic susceptibilities, epigenetic factors, and environmental factors, our schemata on the role of inflammation in complex diseases remain largely patchy, in part due to the success of reductionism in terms of research methodology per se...
July 19, 2016: Molecular BioSystems
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