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https://www.readbyqxmd.com/read/28324673/a-framework-to-guide-the-assessment-of-human-machine-systems
#1
Kimberly Stowers, James Oglesby, Shirley Sonesh, Kevin Leyva, Chelsea Iwig, Eduardo Salas
OBJECTIVE: We have developed a framework for guiding measurement in human-machine systems. BACKGROUND: The assessment of safety and performance in human-machine systems often relies on direct measurement, such as tracking reaction time and accidents. However, safety and performance emerge from the combination of several variables. The assessment of precursors to safety and performance are thus an important part of predicting and improving outcomes in human-machine systems...
March 2017: Human Factors
https://www.readbyqxmd.com/read/28304297/information-and-communication-technologies-for-the-activities-of-daily-living-in-older-patients-with-dementia-a-systematic-review
#2
Grazia D'Onofrio, Daniele Sancarlo, Francesco Ricciardi, Francesco Panza, Davide Seripa, Filippo Cavallo, Francesco Giuliani, Antonio Greco
BACKGROUND: Significant innovations have been introduced in recent years in the application of information and communication technologies (ICTs) to support healthcare for patients with dementia. OBJECTIVE: In the present systematic review, our goal is to keep track of ICT concepts and approaches to support the range of activities of daily living for people with dementia and to provide a snapshot of the effect that technology is having on patients' self-reliance...
March 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28280819/microchip-based-single-cell-functional-proteomics-for-biomedical-applications
#3
REVIEW
Yao Lu, Liu Yang, Wei Wei, Qihui Shi
Cellular heterogeneity has been widely recognized but only recently have single cell tools become available that allow characterizing heterogeneity at the genomic and proteomic levels. We review the technological advances in microchip-based toolkits for single-cell functional proteomics. Each of these tools has distinct advantages and limitations, and a few have advanced toward being applied to address biological or clinical problems that traditional population-based methods fail to address. High-throughput single-cell proteomic assays generate high-dimensional data sets that contain new information and thus require developing new analytical frameworks to extract new biology...
March 10, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28276544/advanced-optoacoustic-methods-for-multiscale-imaging-of-in-vivo-dynamics
#4
REVIEW
X L Deán-Ben, S Gottschalk, B Mc Larney, S Shoham, D Razansky
Visualization of dynamic functional and molecular events in an unperturbed in vivo environment is essential for understanding the complex biology of living organisms and of disease state and progression. To this end, optoacoustic (photoacoustic) sensing and imaging have demonstrated the exclusive capacity to maintain excellent optical contrast and high resolution in deep-tissue observations, far beyond the penetration limits of modern microscopy. Yet, the time domain is paramount for the observation and study of complex biological interactions that may be invisible in single snapshots of living systems...
March 9, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28275251/peer-reviewed-public-health-journals-from-arabic-speaking-countries-an-updated-snapshot
#5
Basil H Aboul-Enein, Joshua Bernstein, Jacquelyn E Bowser
There is a positive association between availability of regional peer-reviewed public health information systems and progressive change in community and population health. The objective of this brief report was to identify public health journals in Arabic-speaking countries actively publishing as of 2016. We conducted an electronic search in several electronic database records for public health journals using a combination of search terms. We excluded journals that focused on human medicine, veterinary medicine, nursing, and other discipline-specific or clinical health professions...
February 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28257031/portal-vein-embolization-impact-of-chemotherapy-and-genetic-mutations
#6
Amy R Deipolyi, Yu Shrike Zhang, Ali Khademhosseini, Sailendra Naidu, Mitesh Borad, Burcu Sahin, Amit K Mathur, Rahmi Oklu
We characterized the effect of systemic therapy given after portal vein embolization (PVE) and before hepatectomy on hepatic tumor and functional liver remnant (FLR) volumes. All 76 patients who underwent right PVE from 2002-2016 were retrospectively studied. Etiologies included colorectal cancer (n = 44), hepatocellular carcinoma (n = 17), cholangiocarcinoma (n = 10), and other metastases (n = 5). Imaging before and after PVE was assessed. Chart review revealed systemic therapy administration, SNaPshot genetic profiling, and comorbidities...
March 1, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28225448/predicting-hcahps-scores-from-hospitals-social-media-pages-a-sentiment-analysis
#7
John W Huppertz, Peter Otto
BACKGROUND: Social media is an important communication channel that can help hospitals and consumers obtain feedback about quality of care. However, despite the potential value of insight from consumers who post comments about hospital care on social media, there has been little empirical research on the relationship between patients' anecdotal feedback and formal measures of patient experience. PURPOSE: The aim of the study was to test the association between informal feedback posted in the Reviews section of hospitals' Facebook pages and scores on two global items from the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, Overall Hospital Rating and Willingness to Recommend the Hospital...
February 22, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28212972/variation-in-health-technology-assessment-and-reimbursement-processes-in-europe
#8
Ronald L Akehurst, Eric Abadie, Noël Renaudin, François Sarkozy
BACKGROUND: It has been suggested that differences in health technology assessment (HTA) processes among countries, particularly within Europe, have led to inequity in patient access to new medicines. OBJECTIVES: To provide an up-to-date snapshot analysis of the present status of HTA and reimbursement systems in select European countries, and to investigate the implications of these processes, especially with regard to delays in market and patient access. METHODS: HTA and reimbursement processes were assessed through a review of published and gray literature, and through a series of interviews with HTA experts...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28173627/genetic-architecture-and-balancing-selection-the-life-and-death-of-differentiated-variants
#9
Violaine Llaurens, Annabel Whibley, Mathieu Joron
Balancing selection describes any form of natural selection which results in the persistence of multiple variants of a trait at intermediate frequencies within populations. By offering up a snapshot of multiple co-occurring functional variants and their interactions, systems under balancing selection can reveal the evolutionary mechanisms favouring the emergence and persistence of adaptive variation in natural populations. We here focus on the mechanisms by which several functional variants for a given trait can arise, a process typically requiring multiple epistatic mutations...
February 7, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28119267/forensic-snp-genotyping-with-snapshot-technical-considerations-for-the-development-and-optimization-of-multiplexed-snp-assays
#10
REVIEW
M Fondevila, C Børsting, C Phillips, M de la Puente, Euroforen-NoE Consortium, A Carracedo, N Morling, M V Lareu
This review explores the key factors that influence the optimization, routine use, and profile interpretation of the SNaPshot single-base extension (SBE) system applied to forensic single-nucleotide polymorphism (SNP) genotyping. Despite being a mainly complimentary DNA genotyping technique to routine STR profiling, use of SNaPshot is an important part of the development of SNP sets for a wide range of forensic applications with these markers, from genotyping highly degraded DNA with very short amplicons to the introduction of SNPs to ascertain the ancestry and physical characteristics of an unidentified contact trace donor...
January 2017: Forensic Science Review
https://www.readbyqxmd.com/read/28078793/insights-into-nuclear-dynamics-using-live-cell-imaging-approaches
#11
REVIEW
Rachel B Bigley, Alexander Y Payumo, Jeffrey M Alexander, Guo N Huang
The nucleus contains the genetic blueprint of the cell and myriad interactions within this subcellular structure are required for gene regulation. In the current scientific era, characterization of these gene regulatory networks through biochemical techniques coupled with systems-wide 'omic' approaches has become commonplace. However, these strategies are limited because they represent a mere snapshot of the cellular state. To obtain a holistic understanding of nuclear dynamics, relevant molecules must be studied in their native contexts in living systems...
March 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/27940518/radial-spokes-a-snapshot-of-the-motility-regulation-assembly-and-evolution-of-cilia-and-flagella
#12
Xiaoyan Zhu, Yi Liu, Pinfen Yang
Propulsive forces generated by cilia and flagella are used in events that are critical for the thriving of diverse eukaryotic organisms in their environments. Despite distinctive strokes and regulations, the majority of them adopt the 9+2 axoneme that is believed to exist in the last eukaryotic common ancestor. Only a few outliers have opted for a simpler format that forsakes the signature radial spokes and the central pair apparatus, although both are unnecessary for force generation or rhythmicity. Extensive evidence has shown that they operate as an integral system for motility control...
December 9, 2016: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/27782430/perspective-kohn-sham-density-functional-theory-descending-a-staircase
#13
Haoyu S Yu, Shaohong L Li, Donald G Truhlar
This article presents a perspective on Kohn-Sham density functional theory (KS-DFT) for electronic structure calculations in chemical physics. This theory is in widespread use for applications to both molecules and solids. We pay special attention to several aspects where there are both concerns and progress toward solutions. These include: 1. The treatment of open-shell and inherently multiconfigurational systems (the latter are often called multireference systems and are variously classified as having strong correlation, near-degeneracy correlation, or high static correlation; KS-DFT must treat these systems with broken-symmetry determinants)...
October 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27767345/bayer-filter-snapshot-hyperspectral-fundus-camera-for-human-retinal-imaging
#14
Joel Kaluzny, Hao Li, Wenzhong Liu, Peter Nesper, Justin Park, Hao F Zhang, Amani A Fawzi
PURPOSE: To demonstrate the versatility and performance of a compact Bayer filter snapshot hyperspectral fundus camera for in-vivo clinical applications including retinal oximetry and macular pigment optical density measurements. METHODS: 12 healthy volunteers were recruited under an Institutional Review Board (IRB) approved protocol. Fundus images were taken with a custom hyperspectral camera with a spectral range of 460-630 nm. We determined retinal vascular oxygen saturation (sO2) for the healthy population using the captured spectra by least squares curve fitting...
October 21, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27746056/evaluating-surgical-residents-quickly-and-easily-against-the-milestones-using-electronic-formative-feedback
#15
Thomas H Hartranft, Kurt Yandle, Tim Graham, Charles Holden, Lowell W Chambers
OBJECTIVE: This study was conducted to assess the effectiveness of a newly implemented electronic web-based review system created at our institution for evaluating resident performance relative to established milestones. DESIGN: Retrospective review of data collected from a survey of general surgery faculty and residents. SETTING: Tertiary care teaching hospital system and independent academic medical center. PARTICIPANTS: A total of 12 general surgery faculty and 17 general surgery residents participated in this study...
October 13, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27742921/peer-reviewed-public-health-journals-from-arabic-speaking-countries-an-updated-snapshot
#16
Basil H Aboul-Enein, Joshua Bernstein, Jacquelyn E Bowser
There is a positive association between availability of regional peer-reviewed public health information systems and progressive change in community and population health. The objective of this brief report was to identify public health journals in Arabic-speaking countries actively publishing as of 2016. We conducted an electronic search in several electronic database records for public health journals using a combination of search terms. We excluded journals that focused on human medicine, veterinary medicine, nursing, and other discipline-specific or clinical health professions...
October 14, 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/27739402/the-si-elegans-project-at-the-interface-of-experimental-and-computational-caenorhabditis-elegans-neurobiology-and-behavior
#17
Alexey Petrushin, Lorenzo Ferrara, Axel Blau
OBJECTIVE: In light of recent progress in mapping neural function to behavior, we briefly and selectively review past and present endeavors to reveal and reconstruct nervous system function in Caenorhabditis elegans through simulation. APPROACH: Rather than presenting an all-encompassing review on the mathematical modeling of C. elegans, this contribution collects snapshots of pathfinding key works and emerging technologies that recent single- and multi-center simulation initiatives are building on...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27712893/two-years-in-igf-research
#18
REVIEW
Briony E Forbes
The last two years of insulin-like growth factor (IGF) research has yielded a vast literature highlighting the central role IGFs factors play in processes such as development, growth, aging and neurological function. It also provides our latest understanding of how IGF system perturbation is linked to diseases including growth deficiency, cancer, and neurological and cardiovascular diseases. A snapshot of the highlights is presented in this review, focussing on the topics of IGFs and growth, comparative and structural biology to understand insulin-like peptide function, IGFs and cancer, and IGFs and neurological function...
October 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27601632/axoneme-structure-from-motile-cilia
#19
REVIEW
Takashi Ishikawa
The axoneme is the main extracellular part of cilia and flagella in eukaryotes. It consists of a microtubule cytoskeleton, which normally comprises nine doublets. In motile cilia, dynein ATPase motor proteins generate sliding motions between adjacent microtubules, which are integrated into a well-orchestrated beating or rotational motion. In primary cilia, there are a number of sensory proteins functioning on membranes surrounding the axoneme. In both cases, as the study of proteomics has elucidated, hundreds of proteins exist in this compartmentalized biomolecular system...
January 3, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/27583669/development-of-the-respiratory-tract-microbiota-in-cystic-fibrosis
#20
Emma M de Koff, Karin M de Winter – de Groot, Debby Bogaert
PURPOSE OF REVIEW: Progression of lung disease in cystic fibrosis (CF) is punctuated by Pseudomonas aeruginosa infection and recurrent pulmonary exacerbations, and is the major determinant of a patient's life expectancy. With the advent of novel deep-sequencing techniques, polymicrobial bacterial assemblages rather than single pathogens seem to be responsible for the deterioration of pulmonary function. This review summarizes recent insights into the development of the CF respiratory tract microbiome, with its determinants and its relations to clinical parameters...
November 2016: Current Opinion in Pulmonary Medicine
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