Yi Tan, Lingchao Miao, Jianbo Xiao, Wai San Cheang
The potential anti-diabetic effect of resveratrol derivative, 3,3',4,5'-tetramethoxy-trans-stilbene (3,3',4,5'-TMS) and its underlying mechanism in high glucose (HG) and dexamethasone (DXMS)-stimulated insulin-resistant HepG2 cells (IR-HepG2) were investigated. 3,3',4,5'-TMS did not reduce the cell viability of IR-HepG2 cells at the concentrations of 0.5-10 µM. 3,3',4,5'-TMS increased the potential of glucose consumption and glycogen synthesis in a concentration-dependent manner in IR-HepG2 cells. 3,3',4,5'-TMS ameliorated insulin resistance by enhancing the phosphorylation of glycogen synthase kinase 3 beta (GSK3β), inhibiting phosphorylation of insulin receptor substrate-1 (IRS-1), and activating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway in IR-HepG2 cells...
May 12, 2022: Current Issues in Molecular Biology