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Resveratrol h

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https://www.readbyqxmd.com/read/29236070/lc-ms-ms-tandem-mass-spectrometry-for-analysis-of-phenolic-compounds-and-pentacyclic-triterpenes-in-antifungal-extracts-of-terminalia-brownii-fresen
#1
Enass Y A Salih, Pia Fyhrquist, Ashraf M A Abdalla, Abdelazim Y Abdelgadir, Markku Kanninen, Marketta Sipi, Olavi Luukkanen, Mustafa K M Fahmi, Mai H Elamin, Hiba A Ali
Decoctions and macerations of the stem bark and wood of Terminalia brownii Fresen. are used in traditional medicine for fungal infections and as fungicides on field crops and in traditional granaries in Sudan. In addition, T. brownii water extracts are commonly used as sprays for protecting wooden houses and furniture. Therefore, using agar disc diffusion and macrodilution methods, eight extracts of various polarities from the stem wood and bark were screened for their growth-inhibitory effects against filamentous fungi commonly causing fruit, vegetable, grain and wood decay, as well as infections in the immunocompromised host...
December 13, 2017: Antibiotics
https://www.readbyqxmd.com/read/29231856/involvement-of-udp-glucuronosyltransferases-and-sulfotransferases-in-the-excretion-and-tissue-distribution-of-resveratrol-in-mice
#2
Michaela Böhmdorfer, Akos Szakmary, Robert H Schiestl, Javier Vaquero, Juliane Riha, Stefan Brenner, Theresia Thalhammer, Thomas Szekeres, Walter Jäger
Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues. Therefore, we investigated the metabolism and tissue distribution of resveratrol in mice and assessed its association with the expression of UDP-glucuronosyltransferase (Ugt) and sulfotransferase (Sult) genes. Plasma, urine, feces, and various organs were analyzed using high-performance liquid chromatography at up to 8 h after intragastric resveratrol administration...
December 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29229512/efficiency-of-resveratrol-loaded-sericin-nanoparticles-promising-bionanocarriers-for-drug-delivery
#3
Kunat Suktham, Thongchai Koobkobkruad, Tuksadon Wutikhun, Suvimol Surassmo
Sericin protein nanoparticles are a biocompatible, bio-viable class of nanocarriers gaining prominence in drug delivery system. This research aimed to investigate the suitability fabrication of silk protein (SP) nanoparticles for loading with resveratrol (RSV) via a solventless precipitation technique. The addition of 0.5% (w/v) pluronic surfactant proved optimal for SP nanoparticle fabrication, with obtained nanoparticles being spherical, mono-dispersed and having mean size of approximately 200-400 nm. All exhibited negative surface charges, the extent of which being dependent on the SP concentration, and were non-toxic to normal skin fibroblasts (CRL-2522)...
December 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29209109/resveratrol-modifies-biliary-secretion-of-cholephilic-compounds-in-sham-operated-and-cholestatic-rats
#4
Eva Dolezelova, Alena Prasnicka, Jolana Cermanova, Alejandro Carazo, Lucie Hyrsova, Milos Hroch, Jaroslav Mokry, Michaela Adamcova, Alena Mrkvicova, Petr Pavek, Stanislav Micuda
AIM: To investigate the effect of resveratrol on biliary secretion of cholephilic compounds in healthy and bile duct-obstructed rats. METHODS: Resveratrol (RSV) or saline were administered to rats by daily oral gavage for 28 d after sham operation or reversible bile duct obstruction (BDO). Bile was collected 24 h after the last gavage during an intravenous bolus dose of the Mdr1/Mrp2 substrate azithromycin. Bile acids, glutathione and azithromycin were measured in bile to quantify their level of biliary secretion...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29207388/resveratrol-does-not-protect-from-ischemia-induced-acute-kidney-injury-in-an-in-vivo-rat-model
#5
Anja Bienholz, Rahel Mae Pang, Hana Guberina, Ursula Rauen, Oliver Witzke, Benjamin Wilde, Frank Petrat, Thorsten Feldkamp, Andreas Kribben
BACKGROUND/AIMS: The natural polyphenol resveratrol (RSV) has been shown to ameliorate ischemia/reperfusion (I/R)-induced damage. Therefore, a rat model of I/R-induced AKI equipped with intensive monitoring was utilized to examine direct renal protection by RSV in vivo. METHODS: AKI was induced by bilateral renal clamping (45 min) followed by reperfusion (3 h). Solvent-free RSV was continuously infused intravenously (0.056 and 0.28 mg/kg) in a total volume of 7 ml/kg/h starting from 30 min before renal clamping...
December 5, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29207192/resveratrol-attenuates-hydrogen-peroxide%C3%A2-induced-apoptosis-reactive-oxygen-species-generation-and-psgl%C3%A2-1-and-vwf-activation-in-human-umbilical-vein-endothelial-cells-potentially-via-mapk-signalling-pathways
#6
Zhenkai Lou, Xingguo Li, Xueling Zhao, Kaili Du, Xing Li, Bing Wang
Reactive oxygen species (ROS) are implicated in the pathogenesis of thrombosis. Studies have reported that resveratrol exhibits antioxidative activities, however, the effect and underlying mechanisms of resveratrol on venous thrombosis remain largely unknown. To investigate the effect of resveratrol on venous thrombosis and the underlying mechanisms, the present study investigated the effects of resveratrol on cell viability, apoptosis, ROS generation and the expression of thrombosis‑associated markers in human umbilical vein endothelial cells (HUVECs)...
November 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29201506/protective-role-of-resveratrol-on-testicular-germ-cells-in-mice-with-testicular-toxicity
#7
Fikriye Yasemin Özatik, Orhan Özatik, Semra Yiğitaslan, Çiğdem Çengelli Ünel, Kevser Erol
Objective: The aim of the present study was to investigate the possible beneficial effects of resveratrol in mice subjected to vinyl cyclohexene dieposide (VCD) -induced testicular toxicity. Material and methods: A total of thirty- six Swiss albino male mice aged 28-days were used in the present study. The study was composed of two stages where mice which received or did not receive VCD (320 mg/kg/day) were administered resveratrol. The animals were assigned into control and resveratrol-treated groups in the first stage and into groups of VCD- and VCD+resveratrol-treated groups in the second stage...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29200719/anti-cancer-effects-of-polyphenolic-compounds-in-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-resistant-non-small-cell-lung-cancer
#8
Hyungmin Jeong, Ai N H Phan, Jong-Whan Choi
Background: Polyphenolic phytochemicals are natural compounds, easily found in fruits and vegetables. Importantly, polyphenols have been intensively studied as excellent antioxidant activity which contributes to anticancer function of the natural compounds. Lung cancer has been reported to mainly account for cancer-related deaths in the world. Moreover, epidermal growth factor receptor tyrosine kinase inhibitor (TKI) resistance is one of the biggest issues in cancer treatment, especially in nonsmall cell lung cancer (NSCLC)...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200030/resveratrol-for-patients-with-chronic-obstructive-pulmonary-disease-hype-or-hope
#9
Rosanne J H C G Beijers, Harry R Gosker, Annemie M W J Schols
PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with a high prevalence of extrapulmonary manifestations and, frequently, cardiovascular comorbidity. Resveratrol is a food-derived compound with anti-inflammatory, antioxidant, metabolic and cardioprotective potential. Therefore, resveratrol might improve the pulmonary as well as extrapulmonary pathology in COPD. In this review, we will evaluate knowledge on the effects of resveratrol on lung injury, muscle metabolism and cardiovascular risk profile and discuss if resveratrol is a hype or hope for patients with COPD...
December 1, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29192844/resveratrol-reduces-light-and-electron-microscopic-changes-in-acetaminophen-induced-hepatotoxicity-in-rats-role-of-inos-expression
#10
Hulya Elbe, Mehmet Gul, Asli Cetin, Elif Taslidere, Fatma Ozyalin, Yusuf Turkoz, Ali Otlu
INTRODUCTION: Hepatotoxicity is a major complication of acetaminophen (APAP), a widely used analgesic and antipyretic drug. Resveratrol (RSV) is a naturally occurring diphenol and it has anticancer, antioxidant, and anti-inflammatory properties. OBJECTIVES: In this study, the beneficial effects of RSV on APAP-induced hepatotoxicity was investigated in rats. MATERIALS AND METHODS: Group 1: Ethanol, Group 2: Saline, Group 3: RSV (10 mg/kg/ip), Group 4: APAP (1000 mg/kg/ip/single dose), Group 5: APAP+RSV (20 min after administration of APAP)...
December 1, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29189984/the-role-of-resveratrol-on-skeletal-muscle-cell-differentiation-and-myotube-hypertrophy-during-glucose-restriction
#11
Hannah F Dugdale, David C Hughes, Robert Allan, Colleen S Deane, Christopher R Coxon, James P Morton, Claire E Stewart, Adam P Sharples
Glucose restriction (GR) impairs muscle cell differentiation and evokes myotube atrophy. Resveratrol treatment in skeletal muscle cells improves inflammatory-induced reductions in skeletal muscle cell differentiation. We therefore hypothesised that resveratrol treatment would improve muscle cell differentiation and myotube hypertrophy in differentiating C2C12 myoblasts and mature myotubes during GR. Glucose restriction at 0.6 g/L (3.3 mM) blocked differentiation and myotube hypertrophy versus high-glucose (4...
November 30, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29179786/a-chemical-compound-based-on-methylxanthine-polyphenols-lowers-nitric-oxide-levels-and-increases-post-thaw-human-sperm-viability
#12
Cleiton Werner, Francine Carla Cadoná, Ivana Beatrice Mânica da Cruz, Eliza Ribas da Silveira Flôres, Alencar Kolinski Machado, Mara Rejane Fantinel, Grazielle Castagna Cezimbra Weis, Charles Elias Assmann, Audrei de Oliveira Alves, Beatriz da Silva Rosa Bonadiman, Euler Esteves Ribeiro, Marco Aurélio Echart Montano
We produced a new chemical compound based on methylxanthines and polyphenols (CCMP) present in the chemical matrix of guaraná (Paullinia cupana), a seed extract with antioxidant properties. After supplementation with the standard extract of resveratrol, a well documented antioxidant found in other plant sources, we investigated whether this resveratrol-enriched compound could improve sperm viability and modulate differentially reactive oxygen species (ROS) and nitric oxide (NO) levels in thawed sperm. Sperm samples obtained from healthy young donors were treated with different concentrations of guaraná extract (0...
November 28, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/29164562/resveratrol-transcriptionally-regulates-mirna-18a-5p-expression-ameliorating-diabetic-nephropathy-via-increasing-autophagy
#13
X-H Xu, D-F Ding, H-J Yong, C-L Dong, N You, X-L Ye, M-L Pan, J-H Ma, Q You, Y-B Lu
OBJECTIVE: To investigate the effects of resveratrol on autophagy in the chronically diabetic nephropathy and to study the effects of the different expression of microRNAs after resveratrol (RSV) treated in db/db mice (diabetic mice). MATERIALS AND METHODS: Db/m (non- diabetic) and db/db mice were randomly divided into intra gastric RSV treatment group or control group. Renal tissues were prepared for HE/PAS staining. In vitro, mouse podocytes cell lines were grown in different mediums with different dose of resveratrol treatment...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29143382/the-effect-of-resveratrol-on-the-developmental-competence-of-porcine-oocytes-vitrified-at-germinal-vesicle-stage
#14
Ecs Santos, R Appeltant, T Q Dang-Nguyen, J Noguchi, H Kaneko, K Kikuchi, T Somfai
We tested the effects of resveratrol both as a pre-treatment and as a recovery treatment after warming during in vitro maturation (IVM) on the viability and developmental competence of porcine oocytes vitrified at the germinal vesicle stage. Pre-treatment before vitrification of oocytes for 3 hr with 2 μM resveratrol did not affect survival, oocyte maturation and embryo developmental competence to the blastocyst stage after parthenogenetic activation. However, supplementation of the medium with resveratrol during subsequent IVM after vitrification and warming significantly improved the ability of surviving oocytes to develop to the blastocyst stage, and this effect was observed only on vitrified, but not on non-vitrified oocytes...
November 16, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29130552/resveratrol-pretreatment-enhanced-homing-of-sdf-1%C3%AE-preconditioned-bone-marrow-derived-mesenchymal-stem-cells-in-a-rat-model-of-liver-cirrhosis
#15
Mehrdad Hajinejad, Parichehr Pasbakhsh, Ameneh Omidi, Keywan Mortezaee, Saied Nekoonam, Reza Mamoudi, Iraj Ragerdi Kashani
Stromal cell-derived factor-1α (SDF-1α) has been known to implicate in homing of MSCs, and resveratrol has been reported to have a positive influence on SDF-1 level in the site of injury. In this study, a combined strategy was applied to evaluate bone marrow-derived MSCs (BMSCs) homing to the rat model of liver cirrhosis induced by common bile duct ligation (CBDL): (1) pretreatment delivery of resveratrol into the cirrhotic liver, and (2) transplantation of ex vivo BMSC preconditioning with SDF-1α. BMSCs were preconditioned with 10 ng/μl SDF-1α for 1h and then labelled with the CM-Dil...
November 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29120391/cytotoxicity-of-labruscol-a-new-resveratrol-dimer-produced-by-grapevine-cell-suspensions-on-human-skin-melanoma-cancer-cell-line-ht-144
#16
Laetitia Nivelle, Jane Hubert, Eric Courot, Nicolas Borie, Jean-Hugues Renault, Jean-Marc Nuzillard, Dominique Harakat, Christophe Clément, Laurent Martiny, Dominique Delmas, Philippe Jeandet, Michel Tarpin
A new resveratrol dimer (1) called labruscol, has been purified by centrifugal partition chromatography of a crude ethyl acetate stilbene extract obtained from elicited grapevine cell suspensions of Vitis labrusca L. cultured in a 14-liter stirred bioreactor. One dimensional (1D) and two dimensional (2D) nuclear magnetic resonance (NMR) analyses including ¹H, (13)C, heteronuclear single-quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and correlation spectroscopy (COSY) as well as high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) were used to characterize this compound and to unambiguously identify it as a new stilbene dimer, though its relative stereochemistry remained unsolved...
November 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29115394/high-glucose-upregulates-endothelin-type-b-receptors-in-vascular-smooth-muscle-cells-via-the-downregulation-of-sirt1
#17
Yan Lin, Yan Zhao, Enqi Liu
Silent information regulator family protein 1 (Sirt1) has recently gained attention for its protective effects against diabetic and cardiovascular diseases (CVDs). Vascular smooth muscle endothelin type B (ETB) receptors are involved in the pathogenesis of CVDs and diabetes. The aim of present study was to explore whether Sirt1 is involved in high glucose (HG)-mediated regulation of ETB receptors in rat superior mesenteric arteries (SMA). The rat SMA segments were cultured in the presence and absence of HG with or without the activator of Sirt1 and specific inhibitor for the extracellular signal-regulated protein kinase 1/2 (ERK1/2) for 24 h...
November 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29107093/resveratrol-enhancement-on-survival-of-staphylococcus-aureus-under-levofloxacin-and-photodynamic-treatments
#18
Maira Gaspar Tosato, Patricia Schilardi, Mónica Fernández Lorenzo de Mele, Andrés H Thomas, Alejandro Miñan, Carolina Lorente
Reactive oxygen species (ROS) are an efficient tool to eradicate microorganisms, due to the capacity of these species to damage almost all types of biomolecules and to kill cells. The increment in the resistance mechanisms to antibiotics leads to the exploration of new strategies to eliminate microorganisms that involves production of ROS, such as superoxide anion (O2(•-)) and hydrogen peroxide (H2O2). ROS are produced during several antimicrobial treatments, including antibiotic and photodynamic therapies...
October 26, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29104641/targeting-sirt1-in-a-rat-model-of-high-fat-diet-induced-non-alcoholic-fatty-liver-disease-comparison-of-gegen-qinlian-decoction-and-resveratrol
#19
Yi Guo, Jun-Xiang Li, Tang-You Mao, Wei-Han Zhao, Li-Juan Liu, Yun-Liang Wang
The present study aimed to explore the mechanism of action of Gegen Qinlian decoction (GGQLD) in experimental non-alcoholic fatty liver disease (NAFLD). A total of 30 rats were randomly divided into five groups: The chow, model, high- and low-dose GGQLD (GGQLD-H and GGQLD-L, respectively) and resveratrol (Resl) groups, and were treated with saline, GGQLD and Resl when a model of high-fat diet (HFD)-induced NAFLD was established. Blood lipid and liver enzymes were detected following treatment for 8 weeks and liver tissue pathology was observed using Oil Red O and haematoxylin and eosin staining...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29103764/additive-cytotoxic-effects-of-radiation-and-mtor-inhibitors-in-a-cervical-cancer-cell-line
#20
Daniele Xavier Assad, Gabriel Alvares Borges, Samuel Ramalho Avelino, Eliete Neves Silva Guerra
The PI3K/AKT/mTOR signaling pathway is frequently activated in HPV-positive cervical squamous cell cancer (CC). This study investigated the biological effects of mTOR inhibitors associated with radiotherapy in a CC cell line (HeLa). A human keratinocyte cell line (HaCaT) was used as control. Temsirolimus, everolimus, resveratrol, curcumin and epigallocatechin gallate (EGCG) were the mTOR inhibitors assessed. The 50% cell cytotoxicity rate (CC50) for each treatment was determined by MTT cell viability assay...
November 2, 2017: Pathology, Research and Practice
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