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Resveratrol h

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https://www.readbyqxmd.com/read/29461680/reducing-autophagy-derived-mitochondrial-dysfunction-during-resveratrol-promotes-fls-cell-apoptosis
#1
Wei Cao, Junqiang Zhang, Gaoyuan Wang, Jinsen Lu, Taorong Wang, Xiaoyu Chen
In rheumatoid arthritis patients, the fibroblast-like synovial cells (FLS) growth is not controlled normally, but is similar to the tumor cells proliferation in histology. Our previous studies have shown that resveratrol inhibits the proliferation of FLS and promotes FLS apoptosis. However, the molecular mechanisms involved in resveratrol-induced FLS apoptosis have not been determined yet. Here, we showed that the FLS cell viability (following pretreatment with 5 µM H2 O2 for 24 h) exhibited better proliferation performance than at other concentrations via the CCK-8 assay...
February 20, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29439261/metabolomics-reveals-protection-of-resveratrol-in-diet-induced-metabolic-risk-factors-in-abdominal-muscle
#2
Guoyou Chen, Guozhu Ye, Xinbo Zhang, Xiaoxiao Liu, Yingfeng Tu, Zengjie Ye, Jincheng Liu, Qi Guo, Zhiguo Wang, Lin Wang, Sijun Dong, Yuhua Fan
BACKGROUND/AIMS: Abdominal obesity is recognized as the main reason of metabolic syndrome, which is closely related to disordered skeletal and/or abdominal muscle metabolic functions. Metabolomics is a comprehensive assessment system in biological metabolites. The aim of our present study is to investigate the diet-induced metabolic risk factors by metabolic in the abdominal muscles and clarify the relationship between atheroprotective effects of Resveratrol (Rev) and abdominal muscles metabolic components during the development of atherosclerosis...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29434742/resveratrol-protects-neuronal-cells-from-isoflurane-induced-inflammation-and-oxidative-stress-associated-death-by-attenuating-apoptosis-via-akt-p38-mapk-signaling
#3
Weilan Hu, Ei Yang, Jianxin Ye, Weili Han, Zeng-Li Du
The aim of the present study was to determine whether resveratrol protects neuronal cells from inflammation and isoflurane-induced oxidative stress-associated death via attenuating apoptosis via Akt/p38 mitogen-activated protein kinase (MAPK) signaling. The PC12 rat pheochromocytoma cell line was treated with 2% isoflurane + 21% O2 + 5% CO2 for 6 h and pre-treated with resveratrol (0-1,000 µM) for 0, 24 or 48 h prior to isoflurane treatment. An MTT assay, flow cytometry and ELISA of tumor necrosis factor-α, interleukin-6, malondialdehyde and superoxide dismutase revealed that resveratrol reduced growth inhibition, restrained apoptosis and suppressed inflammation and oxidative stress induced by isoflurane in PC12 cells...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29427784/evaluation-of-the-treatment-with-resveratrol-loaded-nanoparticles-in-intestinal-injury-model-caused-by-ischemia-and-reperfusion
#4
Stephanie Carvalho Borges, Paulo Emílio Botura Ferreira, Luisa Mota da Silva, Maria Fernanda de Paula Werner, Juan Manuel Irache, Osvaldo Albuquerque Cavalcanti, Nilza Cristina Buttow
The gastrointestinal tract is extremely sensitive to ischemia and reperfusion (I/R). Studies have reported that resveratrol (RSV) is able to combat damage caused by intestinal I/R. Because of its effectiveness in increasing the permanence and bioavailability of resveratrol in the intestinal epithelium, we investigated whether the effect of resveratrol-loaded in poly(anhydride) nanoparticles reduce oxidative stress and promote myenteric neuroprotection in the ileum of rats subjected to I/R. Physicochemical evaluations were performed on nanoparticles...
February 7, 2018: Toxicology
https://www.readbyqxmd.com/read/29411409/the-impact-of-electric-fields-on-testis-physiopathology-sperm-parameters-and-dna-integrity-the-role-of-resveratrol
#5
R Aslankoc, N Gumral, M Saygin, N Senol, H Asci, F N Cankara, S Comlekci
This study investigated the long-term effects of electric fields (EF) which might cause physiopathological or morphological changes in the testis tissues of rats. We assumed that using resveratrol (RES) might reduce harmful effects of the EF. Thirty-two male Wistar Albino rats were randomly divided into four groups with eight animals in each; control, EF, EF + RES and RES. Malondialdehyde (MDA), superoxide dismutase, catalase, glutathione peroxidase and histopathological parameters were evaluated in testis tissue...
February 6, 2018: Andrologia
https://www.readbyqxmd.com/read/29411055/improved-neuroprotective-effect-of-resveratrol-nanoparticles-as-evinced-by-abrogation-of-rotenone-induced-behavioral-deficits-and-oxidative-and-mitochondrial-dysfunctions-in-rat-model-of-parkinson-s-disease
#6
Suresh Palle, Prasad Neerati
The objective of the present study was to evaluate the protective effect of resveratrol nanoparticles (NRSV) against rotenone-induced neurodegeneration in rats. NRSV were prepared by temperature-controlled antisolvent precipitation method and characterized for its particle size, shape, and dissolution properties. Moreover, NRSV effects compared with the free resveratrol (RSV). Animals were divided into four groups: (I) control, (II) rotenone (2 mg/kg s.c.), (III) RSV (40 mg/kg, p.o.) + rotenone, and (IV) NRSV (40 mg/kg, p...
February 6, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29390972/establishment-of-malignantly-transformed-dendritic-cell-line-su3-ihdctc-induced-by-glioma-stem-cells-and-study-on-its-sensitivity-to-resveratrol
#7
Xifeng Fei, Anqi Wang, Delin Wang, Xan Meng, Jiawei Ma, Lei Hong, Ruwei Qin, Aidong Wang, Jun Dong, Qiang Huang, Zhimin Wang
BACKGROUND: As a factor contributing to the tumor cell drug resistance, tumor microenvironment (TME) is being paid increasingly attention. However, the drug resistance of malignantly transformed cells in TME has rarely been revealed. This paper is designed to investigate the sensitivity of malignantly transformed cell line (ihDCTC) induced by glioma stem cells (GSCs) in TME to chemotherapeutic drugs. METHODS: (1) Establishment of ihDCTC cell line,The bone marrow cells from enhanced green fluorescent protein (EGFP) transgenic nude mice were employed to culture the dendritic cells (DCs) in vitro, which were then co-cultured with red fluorescence protein (RFP) transgenic GSCs (SU3) to obtain ihDCTC (2) Res and Cis were used to intervene in the growth of abovemetioned cell lines in vitro and Res treated in bearing ihDCTC tumor mice, followed by evaluating their drug sensitivity and changes in key signaling proteins via half maximal inhibitory concentration (IC50), tumor mass and immunostaining method...
February 2, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29385102/preventive-effects-of-resveratrol-on-endocannabinoid-system-and-synaptic-protein-modifications-in-rat-cerebral-cortex-challenged-by-bilateral-common-carotid-artery-occlusion-and-reperfusion
#8
Gianfranca Carta, Laura Poddighe, Maria Pina Serra, Marianna Boi, Tiziana Melis, Sara Lisai, Elisabetta Murru, Laura Muredda, Maria Collu, Sebastiano Banni, Marina Quartu
This study aims to evaluate the putative roles of a single acute dose of resveratrol (RVT) in preventing cerebral oxidative stress induced by bilateral common carotid artery occlusion, followed by reperfusion (BCCAO/R) and to investigate RVT's ability to preserve the neuronal structural integrity. Frontal and temporal-occipital cortices were examined in two groups of adult Wistar rats, sham-operated and submitted to BCCAO/R. In both groups, 6 h before surgery, half the rats were gavage-fed with a single dose of RVT (40 mg/per rat in 300 µL of sunflower oil as the vehicle), while the second half received the vehicle alone...
January 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29380895/use-of-polyphenols-as-a-strategy-to-prevent-bond-degradation-in-the-dentin-resin-interface
#9
Isabel C C M Porto, Ticiano G Nascimento, José M S Oliveira, Pedro H Freitas, Asmaa Haimeur, Rodrigo França
This study evaluated the effect of dentin pretreatment with the polyphenols quercetin and resveratrol on the resin-dentin microtensile bonding strength (μTBS) and collagen fibrils stability of the adhesive interface. Different concentrations (100, 250, 500, or 1,000 μg ml-1 ) of quercetin or resveratrol, or a mixture of quercetin and resveratrol (3:1, 1:1, 1:3; vol:vol), as well as distilled water or 2% chlorhexidine digluconate, were applied to etched dentin. Then, a two-step etch-and-rinse adhesive was applied followed by composite restoration...
January 30, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29374923/-effects-of-microrna-34a-on-regulating-silent-information-regulator-1-and-influence-of-the-factor-on-myocardial-damage-of-rats-with-severe-burns-at-early-stage
#10
X Z Bai, T He, J L Zhang, Y Liu, M Y Cao, J N Zhang, W X Cai, Y H Jia, J H Shi, L L Su, D H Hu
Objective: To explore the effects of microRNA-34a on regulating silent information regulator 1 (SIRT1) and influence of SIRT1 on myocardial damage of rats with severe burns at early stage. Methods: (1) Twenty-four Sprague-Dawley (SD) rats were divided into sham injury (SI) group, simple burns (SB) group and SIRT1 agonist (SA) group according to the random number table (the same grouping method below), with 8 rats in each group. Rats in groups SB and SA were inflicted with 30% total body surface area full-thickness scald (hereinafter referred to as burns) on the back, and rats in group SI were sham injuried on the back...
January 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29363137/a-potential-role-for-the-silent-information-regulator-2-homologue-1-sirt1-in-periapical-periodontitis
#11
H Kudo, O Takeichi, K Hatori, K Makino, K Himi, B Ogiso
AIM: To investigate the role played by silent information regulator 2 homologue 1 (SIRT1) during angiogenesis of periapical periodontitis. METHODOLOGY: Periapical granulomas were subjected to dual-colour immunofluorescence imaging and real-time polymerase chain reactions assaying the expression levels of SIRT1, vascular endothelial growth factor (VEGF), and VE-cadherin. The association between Ki-67 and SIRT1 expression was also examined. Human umbilical vein endothelial cells (HUVECs) were treated with a combination of lipopolysaccharide and resveratrol (a SIRT1 activator) or sirtinol (a SIRT1 inhibitor); and the levels of mRNAs encoding SIRT1, VEGF, and VE-cadherin were determined...
January 24, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29360689/resveratrol-protects-early-brain-injury-after-subarachnoid-hemorrhage-by-activating-autophagy-and-inhibiting-apoptosis-mediated-by-the-akt-mtor-pathway
#12
Dan Guo, Jiangtao Xie, Junjie Zhao, Tingqin Huang, Xiaoye Guo, Jinning Song
Early brain injury (EBI) plays a key role in determining the prognosis of patients suffering from subarachnoid hemorrhage (SAH). Resveratrol, a natural polyphenol, serves a neuroprotection function on EBI after SAH. However, the potential mechanism of resveratrol on EBI remains to be elucidated. Akt, also known as protein kinase B, and mammalian target of rapamycin (mTOR), the downstream protein of Akt, play key roles in cell survival and apoptosis, cell cycle regulation, and cellular protein homeostasis. In the present study, we examined the effect of resveratrol on EBI and their potential relationship with the Akt/mTOR pathway, autophagy, and apoptosis...
January 22, 2018: Neuroreport
https://www.readbyqxmd.com/read/29356901/glycine-enhances-expression-of-adiponectin-and-il-10-in-3t3-l1-adipocytes-without-affecting-adipogenesis-and-lipolysis
#13
Jingqing Chen, Xiaoshi Ma, Ying Yang, Zhaolai Dai, Zhenlong Wu, Guoyao Wu
Glycine supplementation has been reported to enhance white-fat loss and improve sensitivity to insulin in animals with obesity or type 2 diabetes. However, the underlying mechanisms responsible for the beneficial effects of glycine remain largely unknown. The purpose of this study was to test the hypothesis that glycine regulates adipocyte differentiation, adipogenesis, and lipolysis, therefore, contributing to white-fat reduction. 3T3-L1 pre-adipocytes were induced to differentiate into adipocytes in the presence of glycine (0, 0...
January 22, 2018: Amino Acids
https://www.readbyqxmd.com/read/29336987/the-in-vitro-radiosensitizer-potential-of-resveratrol-on-mcf-7-breast-cancer-cells
#14
Isabel Cristina da Costa Araldi, Fernando Primitivo Romero Bordin, Francine Carla Cadoná, Fernanda Barbisan, Verônica Farina Azzolin, Cibele Ferreira Teixeira, Tadeu Baumhardt, Ivana Beatrice Mânica da Cruz, Marta Maria Medeiros Frescura Duarte, Liliane de Freitas Bauermann
Radiation therapy is commonly applied in breast cancer (BC) patients. However, radioresistance and side effects are limiting factors of this practice. Therefore, studying substances that can enhance the radiation effect and, at the same time, protect normal cells is very relevant. Thus, the aim of this work was to assess the radiosensitizer effect of resveratrol (RV) on BC cells (MCF-7). A high cytotoxic and antiproliferative effect was observed in the treatment with 10 μM of RV + 3 Gy ionizing radiation (IR)...
January 11, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29316254/resveratrol-induced-apoptosis-in-human-gastric-carcinoma-sgc-7901-cells-via-activation-of-mitochondrial-pathway
#15
Yining Yang, Xinen Huang, Senqing Chen, Guojian Ma, Ming Zhu, Feng Yan, Jun Yu
BACKGROUND: Resveratrol is a natural polyphenolic compound and its anticancer effect has been receiving considerable attention. Previous studies showed that resveratrol could inhibited the growth of human gastric carcinoma cells and apoptosis induction was an important mechanism. However, whether mitochondrial pathway was involved in resveratrol-induced apoptosis in human gastric cancer was not very clear. METHODS: The cells were examined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, Annexin V/PI staining assay, mitochondrial membrane depolarization, cell morphological assessment, cytochrome c release assay, and Western blotting assay...
January 8, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29287203/dj-1-preserving-mitochondrial-complex-i-activity-plays-a-critical-role-in-resveratrol-mediated-cardioprotection-against-hypoxia-reoxygenation-induced-oxidative-stress
#16
Yi Zhang, Xiao-Ran Li, Le Zhao, Guang-Ling Duan, Lin Xiao, He-Ping Chen
Resveratrol has been demonstrated to have cardioprotective effects by attenuating ischemia/reperfusion (I/R)-induced oxidative stress injury, but its in-depth molecular mechanisms against I/R-induced oxidative stress is not fully elaborated. DJ-1 plays a role in maintenance of mitochondrial complex I activity and is closely associated with oxidative stress. Therefore, this study sought to determine the contribution of DJ-1-mediated maintenance of mitochondrial complex I activity to the anti-oxidative stress effect of Resveratrol in the H9c2 cardiomyocytes subjected to hypoxia/reoxygenation (H/R)...
December 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29241147/combined-enzymatic-and-metabolic-analysis-of-grapevine-cell-responses-to-elicitors
#17
Yuko Krzyzaniak, Jonathan Negrel, Christelle Lemaitre-Guillier, Gilles Clément, Grégory Mouille, Agnès Klinguer, Sophie Trouvelot, Marie-Claire Héloir, Marielle Adrian
Elicitors trigger plant defense responses, including phytoalexin production and cell-wall reinforcement. Primary metabolism plays an important role in these responses as it fuels the associated energetic costs and provides precursors for the synthesis of the numerous secondary metabolites involved in defenses against pathogens. In this context, we aimed to determine whether oligosaccharidic elicitors differing in their capacity to activate defense-associated secondary metabolism in grapevine would differently impact primary metabolism...
December 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29236070/lc-ms-ms-tandem-mass-spectrometry-for-analysis-of-phenolic-compounds-and-pentacyclic-triterpenes-in-antifungal-extracts-of-terminalia-brownii-fresen
#18
Enass Y A Salih, Pia Fyhrquist, Ashraf M A Abdalla, Abdelazim Y Abdelgadir, Markku Kanninen, Marketta Sipi, Olavi Luukkanen, Mustafa K M Fahmi, Mai H Elamin, Hiba A Ali
Decoctions and macerations of the stem bark and wood of Terminalia brownii Fresen. are used in traditional medicine for fungal infections and as fungicides on field crops and in traditional granaries in Sudan. In addition, T. brownii water extracts are commonly used as sprays for protecting wooden houses and furniture. Therefore, using agar disc diffusion and macrodilution methods, eight extracts of various polarities from the stem wood and bark were screened for their growth-inhibitory effects against filamentous fungi commonly causing fruit, vegetable, grain and wood decay, as well as infections in the immunocompromised host...
December 13, 2017: Antibiotics
https://www.readbyqxmd.com/read/29231856/involvement-of-udp-glucuronosyltransferases-and-sulfotransferases-in-the-excretion-and-tissue-distribution-of-resveratrol-in-mice
#19
Michaela Böhmdorfer, Akos Szakmary, Robert H Schiestl, Javier Vaquero, Juliane Riha, Stefan Brenner, Theresia Thalhammer, Thomas Szekeres, Walter Jäger
Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues. Therefore, we investigated the metabolism and tissue distribution of resveratrol in mice and assessed its association with the expression of UDP-glucuronosyltransferase (Ugt) and sulfotransferase (Sult) genes. Plasma, urine, feces, and various organs were analyzed using high-performance liquid chromatography at up to 8 h after intragastric resveratrol administration...
December 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29229512/efficiency-of-resveratrol-loaded-sericin-nanoparticles-promising-bionanocarriers-for-drug-delivery
#20
Kunat Suktham, Thongchai Koobkobkruad, Tuksadon Wutikhun, Suvimol Surassmo
Sericin protein nanoparticles are a biocompatible, bio-viable class of nanocarriers gaining prominence in drug delivery system. This research aimed to investigate the suitability fabrication of silk protein (SP) nanoparticles for loading with resveratrol (RSV) via a solventless precipitation technique. The addition of 0.5% (w/v) pluronic surfactant proved optimal for SP nanoparticle fabrication, with obtained nanoparticles being spherical, mono-dispersed and having mean size of approximately 200-400 nm. All exhibited negative surface charges, the extent of which being dependent on the SP concentration, and were non-toxic to normal skin fibroblasts (CRL-2522)...
December 8, 2017: International Journal of Pharmaceutics
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