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https://www.readbyqxmd.com/read/28637522/evaluation-of-urinary-resveratrol-as-a-biomarker-of-dietary-resveratrol-intake-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-study
#1
Raul Zamora-Ros, Joseph A Rothwell, David Achaintre, Pietro Ferrari, Marie-Christine Boutron-Ruault, Francesca R Mancini, Aurelie Affret, Tilman Kühn, Verena Katzke, Heiner Boeing, Sven Küppel, Antonia Trichopoulou, Pagona Lagiou, Carlo La Vecchia, Domenico Palli, Paolo Contiero, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Hwayoung Noh, Heinz Freisling, Isabelle Romieu, Augustin Scalbert
In vitro studies have shown several beneficial properties of resveratrol. Epidemiological evidence is still scarce, probably because of the difficulty in estimating resveratrol exposure accurately. The current study aimed to assess the relationships between acute and habitual dietary resveratrol and wine intake and urinary resveratrol excretion in a European population. A stratified random subsample of 475 men and women from four countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study, who had provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day, were included...
June 22, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28610486/resveratrol-loaded-glycyrrhizic-acid-conjugated-human-serum-albumin-nanoparticles-wrapping-resveratrol-nanoparticles-preparation-characterization-and-targeting-effect-on-liver-tumors
#2
Mingfang Wu, Bolin Lian, Yiping Deng, Ziqi Feng, Chen Zhong, Weiwei Wu, Yannian Huang, Lingling Wang, Chang Zu, Xiuhua Zhao
In this study, glycyrrhizic acid-conjugated human serum albumin nanoparticles wrapping resveratrol nanoparticles were prepared to establish a tumor targeting nano-sized drug delivery system. Glycyrrhizic acid was coupled to human serum albumin, and resveratrol was encapsulated in glycyrrhizic acid-conjugated human serum albumin by high-pressure homogenization emulsification. The average particle size of sample nanoparticles prepared under the optimal conditions was 108.1 ± 5.3 nm with a polydispersity index (PDI) of 0...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28599439/anti-proliferative-and-anti-metastasis-effects-of-ten-oligostilbenes-from-the-seeds-of-paeonia-suffruticosa-on-human-cancer-cells
#3
Ying Gao, Chunnian He
Paeonia suffruticosa from the section Moutan of the genus Paeonia is an important Chinese medicinal herb. In our previous study, 10 oligostilbenes from the seeds of P. suffruticosa, including trans-resveratrol and its dimers and trimers, were isolated and identified. In the present study, the anti-proliferative effects of these 10 oligostilbenes were systemically evaluated in a panel of human lung, breast and bone cancer cell lines, and their apoptotic effects were analyzed using a high-content multiplex apoptosis assay and a fluorescent caspase-3/7 assay...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28596842/effects-of-resveratrol-on-drug-and-carcinogen-metabolizing-enzymes-implications-for-cancer-prevention
#4
REVIEW
Ariane R Guthrie, H-H Sherry Chow, Jessica A Martinez
Resveratrol is a polyphenol found in grape skins and peanuts that has demonstrated many health benefits including protection against aging, cardiovascular and metabolic disease, neurological decline, and cancer. The anticancer properties of resveratrol have been attributed to a variety of mechanisms, including its general inhibition of phase I metabolism and induction of phase II metabolism. The effects of resveratrol on these enzymes, however, are still unclear, as in vitro evidence often contrasts with animal studies and clinical trials...
February 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28589947/gut-microbiota-composition-in-relation-to-the-metabolic-response-to-12-week-combined-polyphenol-supplementation-in-overweight-men-and-women
#5
J Most, J Penders, M Lucchesi, G H Goossens, E E Blaak
BACKGROUND/OBJECTIVES: The intestinal microbiota may have a profound impact on host metabolism. As evidence suggests that polyphenols affect substrate utilization, the present study aimed to investigate the effects of polyphenol supplementation on intestinal microbiota composition in humans. Furthermore, we examined whether (changes in) gut microbiota composition may determine the metabolic response to polyphenol supplementation. SUBJECTS/METHODS: In this randomized, double-blind, placebo (PLA)-controlled trial, 37 overweight and obese men and women (18 males/19 females, 37...
June 7, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28588600/date-palm-tree-phoenix-dactylifera-l-natural-products-and-therapeutic-options
#6
REVIEW
Reem A Al-Alawi, Jawhara H Al-Mashiqri, Jawaher S M Al-Nadabi, Badria I Al-Shihi, Younis Baqi
Many plants, including some of the commonly consumed herbs and spices in our daily food, can be safely and effectively used to prevent and/or treat some health concerns. For example, caffeine the active ingredient found in coffee beans (Coffea), shows biological activity in the treatment of the central nervous system (CNS) disorders, indole-3-carbinol, and 3,3'-diindolylmethane are both broccoli (Brassica oleracea) derived phytochemicals with potential anti-cancer activity, and resveratrol, isolated from grape (Vitis vinifera), is reported to extend lifespan and provide cardio-neuro-protective, anti-diabetic, and anti-cancer effects...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28586010/resveratrol-protects-against-l-arginine-induced-acute-necrotizing-pancreatitis-in-mice-by-enhancing-sirt1-mediated-deacetylation-of-p53-and-heat-shock-factor-1
#7
Nian Wang, Fen Zhang, Liu Yang, Jiang Zou, Hao Wang, Ke Liu, Meidong Liu, Huali Zhang, Xianzhong Xiao, Kangkai Wang
Acute necrotizing pancreatitis (ANP) is a common severe critical illness with a high mortality rate. Resveratrol, a polyphenol compound derived from various plants such as grape skin, peanut, berry and veratrum, exhibits multiple biological activities, especially potent anti‑inflammatory activity, but its effect on ANP has not yet been fully elucidated. The present study aimed to investigate the effects of resveratrol on L-arginine-induced ANP and the possible mechanisms. A mouse model of ANP was established by 2 hourly intraperitoneal injections of 8% L-arginine (4 g/kg)...
June 6, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28578410/resveratrol-pretreatment-attenuates-concanavalin-a-induced-hepatitis-through-reverse-of-aberration-in-the-immune-response-and-regenerative-capacity-in-aged-mice
#8
Tse-Hung Huang, Chin-Chang Chen, Hsuan-Miao Liu, Tzung-Yan Lee, Sue-Heui Shieh
Loss of regenerative capacity plays a critical role in age-related autoimmune hepatitis. Evidence implicates SIRT1 and p66(shc) in cell senescence, apoptosis, oxidative stress, and proliferation. This study investigated the effect of resveratrol on concanavalin A (Con A)-induced hepatitis in aged mice and the roles of SIRT1 and p66(shc). Aged mice were administrated resveratrol (30 mg/kg orally) seven times at an interval of 12 h before a single intravenous injection of Con A (20 mg/kg). Results showed that the cytokines, TNF-α, IL-6, IFN-γ, and MCP-1, as well as infiltration of macrophages, neutrophils, and T lymphocytes in liver were dramatically enhanced in the mice given only Con A...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28578073/identification-of-endocrine-disrupting-chemicals-acting-on-human-aromatase
#9
Roberta Baravalle, Alberto Ciaramella, Francesca Baj, Giovanna Di Nardo, Gianfranco Gilardi
Human aromatase is the cytochrome P450 catalysing the conversion of androgens into estrogens playing a key role in the endocrine system. Due to this role, it is likely to be a target of the so-called endocrine disrupting chemicals, a series of compounds able to interfere with the hormone system with toxic effects. If on one side the toxicity of some compounds such as bisphenol A is well known, on the other side the toxic concentrations of such compounds as well as the effect of the many other molecules that are in contact with us in everyday life still need a deep investigation...
May 31, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28577913/anticonvulsant-activity-of-resveratrol-loaded-liposomes-in-vivo
#10
M S Ethemoglu, F B Seker, H Akkaya, E Kilic, I Aslan, C S Erdogan, B Yilmaz
Resveratrol (3,5,4'-stilbenetriol), a natural polyphenol produced by various plants, has attracted attention over the past decade because of its multiple beneficial properties, including anti-inflammatory, anti-oxidant and chemopreventive, yet, there is limited information about its antiepileptic effects. Moreover, its poor solubility in water and low bioavailability are the challenging issues. In the present study, we aimed to investigate effects of free resveratrol and resveratrol delivered in amphipathic liposomal delivery system, which has a high blood-brain barrier crossing potential, on penicillin-induced epileptic seizure model...
June 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/28574732/in-vitro-and-in-vivo-evaluation-of-cubosomal-in-situ-nasal-gel-containing-resveratrol-for-brain-targeting
#11
Mayuri Ahirrao, Shilpa Shrotriya
The aim of this study was to enhance the delivery of resveratrol to the brain through the transnasal route by cubosomes. Cubosomes were prepared using glycerol monooleate and Lutrol F127 by probe sonication method. A 3(2) full factorial design was used for optimization of cubosomes and batch containing 4% w/v glycerol monooleate and 1.5% w/v of Lutrol F 127 was optimized. The selected cubosomal batch was cubical in shape, having mean particle size 161.5±0.12 nm. Entrapment efficiency was found to be 83.08% with zeta potential of - 20...
June 2, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28574511/signalome-wide-rnai-screen-identifies-gba1-as-a-positive-mediator-of-autophagic-cell-death
#12
Santosh K Dasari, Shani Bialik, Smadar Levin-Zaidman, Vered Levin-Salomon, Alfred H Merrill, Anthony H Futerman, Adi Kimchi
Activating alternative cell death pathways, including autophagic cell death, is a promising direction to overcome the apoptosis resistance observed in various cancers. Yet, whether autophagy acts as a death mechanism by over consumption of intracellular components is still controversial and remains undefined at the ultrastructural and the mechanistic levels. Here we identified conditions under which resveratrol-treated A549 lung cancer cells die by a mechanism that fulfills the previous definition of autophagic cell death...
June 2, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28558868/anti-hyperuricemic-and-anti-inflammatory-actions-of-vaticaffinol-isolated-from-dipterocarpus-alatus-in-hyperuricemic-mice
#13
Yu-Sheng Chen, Chao-Jun Chen, Wei Yan, Hui-Ming Ge, Ling-Dong Kong
The present study was designed to examine the anti-hyperuricemic and anti-inflammatory effects and possible mechanisms of vaticaffinol, a resveratrol tetramer isolated from ethanol extracts of Dipterocarpus alatus, in oxonate-induced hyperuricemic mice. At 1 h after 250 mg·kg(-1) potassium oxonate was given, vaticaffinol at 20, 40, and 60 mg·kg(-1) was intragastrically administered to hyperuricemic mice once daily for seven consecutive days. Vaticaffinol significantly decreased serum uric acid levels and improved kidney function in hyperuricemic mice...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28552110/antitumor-effect-of-thymoquinone-combined-with-resveratrol-on-mice-transplanted-with-breast-cancer
#14
Omar H Alobaedi, Wamidh H Talib, Iman A Basheti
OBJECTIVE: To test the anticancer potential activity of the combination of thymoquinone (TQ) and resveratrol (RES) against breast cancer in mice. METHODS: The antiproliferative activity of TQ, RES and their combination was assessed against three breast cancer cell lines and one normal cells using MTT assay. The combination index was calculated using isobolographic method. Balb/C mice were inoculated with EMT6/P cells and in vivo antitumor activity was evaluated...
April 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28550734/pterostilbene-alleviates-polymicrobial-sepsis-induced-liver-injury-possible-role-of-sirt1-signaling
#15
Xiaojing Liu, Xueliang Yang, Lingna Han, Feng Ye, Min Liu, Wanhu Fan, Kai Zhang, Ying Kong, Jian Zhang, Lei Shi, Yunru Chen, Xi Zhang, Shumei Lin
Liver injury occurs frequently during sepsis. Pterostilbene (Pte), a natural dimethylated analog of resveratrol from blueberries, exerts anti-inflammatory and anti-apoptotic effects in various diseases. However, the role of Pte in sepsis-induced liver injury and its underlying mechanisms remain unknown. The current study aimed to evaluate the protective effects of Pte on sepsis-induced liver injury and its potential mechanisms. Sepsis was induced using cecal ligation and puncture (CLP) in C57BL/6 mice. Mice were administered Pte (5, 10, 15mg/kg, i...
May 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28548224/resveratrol-beneficially-affects-meat-quality-of-heat-stressed-broilers-which-is-associated-with-changes-in-muscle-antioxidant-status
#16
Cheng Zhang, Xiaohui Zhao, Li Wang, Lei Yang, Xingyong Chen, Zhaoyu Geng
This study was conducted to evaluate the effect of dietary resveratrol (Res) supplementation on serum parameters, meat quality and muscle antioxidant status of broilers under heat stress (HS). A total of 270 21-day-old male Cobb broilers were randomly assigned to three treatment groups with six replicates of 15 birds each. The three treatment groups were as follows: the control group, in which birds were reared at 22 ± 1°C, and the HS and HS + Res (400 mg/kg) groups, in which birds were reared at 33 ± 1°C for 10 h (08...
May 26, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28533128/polyphenol-inhibition-of-benzo-a-pyrene-induced-oxidative-stress-and-neoplastic-transformation-in-an-in%C3%A2-vitro-model-of-carcinogenesis
#17
Kosar Omidian, Hossein Rafiei, Brian Bandy
While dietary polyphenols are widely recognized for cancer-preventing characteristics, the relative effectiveness and mechanisms of action of different polyphenols is not clear. In the present study, we investigated the protective effects of six different polyphenols against benzo[a]pyrene (B[a]P)-induced oxidative stress and neoplastic transformation in the Bhas 42 cell carcinogenesis assay. All of the polyphenols completely prevented the increased intracellular ROS generation by B[a]P at 12 h, and most inhibited after 3 days...
May 19, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28531100/functional-mitochondria-are-important-for-the-effect-of-resveratrol
#18
Anne L Widlund, Kaushal Baral, Louise T Dalgaard, Ole Vang
Resveratrol (Resv) is a polyphenol reported to modulate mitochondrial activity. The aim was to use HeLa and 143B cells to characterize the action of Resv on mitochondrial activity, cell size and proliferation using wild type (WT) and Rho 0 cells deficient in mitochondrial DNA. In both HeLa WT and Rho 0 cells, the oxygen consumption rate (OCR) was increased at 20 µM Resv after 24 h, whereas only a non-significant increase of OCR was observed in 143B WT cells. Resv decreased cell number concentration-dependently in both WT and Rho 0 cell types...
May 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28516788/anti-oxidative-effect-of-resveratrol-on-aluminum-induced-toxicity-in-rat-cerebral-tissue
#19
M M H Zakaria, B Hajipour, R Estakhri, B M Saleh
INTRODUCTION: The direct protective effects of resveratrol against oxidative stress have been demonstrated in neuroglial cells, the mechanisms of these effects are not fully understood. The aim of this research was to study the effect of resveratrol on AL induced cerebral injury in rat. METHODS: We divided the groups as follows with 10 animals each: a) Group I - served as control receiving normal drinking water and diet ad libitum. b) Group II - animals were administered aluminum at a dose level of 100 mg/kg body weight for a period of 6 weeks daily through oral gavage...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28512471/resveratrol-induces-differentiation-of-human-umbilical-cord-mesenchymal-stem-cells-into-neuron-like-cells
#20
Li Guo, Liang Wang, Li Wang, Shi Yun-Peng, Jing-Jing Zhou, Zongmao Zhao, De-Pei Li
Objective. Human umbilical cord mesenchymal stem cells (hUC-MSCs) potentially differentiate to various types of cells including neuron-like cells. The natural polyphenol resveratrol benefits patients with many diseases including ischemic brain injury. We hypothesize that resveratrol induces differentiation of hUC-MSCs into neuron-like cells. Methods. Flow cytometry was used to determine the surface antigens in different stage of hUC-MSCs (P2, P5, and P10). Nestin, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP) were detected by immunocytochemistry, Western blotting, and real time RT-PCT...
2017: Stem Cells International
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