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https://www.readbyqxmd.com/read/28192638/nitrate-decline-unlikely-to-have-triggered-release-of-dissolved-organic-carbon-and-phosphate-to-streams
#1
Karsten Kalbitz, Klaus Kaiser, William H McDowell
Concentrations of dissolved organic carbon (DOC) increased in many surface waters in Europe and North America over the last two or three decades (Monteith et al., 2007; Garmo et al., 2014). The increase has been attributed to increased DOC export from terrestrial ecosystems in response to decreasing acidic atmospheric deposition, increasing temperature and CO2 concentrations, and altered hydrology (summarized by Finstad et al., 2016). This article is protected by copyright. All rights reserved.
February 13, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28191504/distinct-biogeographic-patterns-for-archaea-bacteria-and-fungi-along-the-vegetation-gradient-at-the-continental-scale-in-eastern-china
#2
Bin Ma, Zhongmin Dai, Haizhen Wang, Melissa Dsouza, Xingmei Liu, Yan He, Jianjun Wu, Jorge L M Rodrigues, Jack A Gilbert, Philip C Brookes, Jianming Xu
The natural forest ecosystem in Eastern China, from tropical forest to boreal forest, has declined due to cropland development during the last 300 years, yet little is known about the historical biogeographic patterns and driving processes for the major domains of microorganisms along this continental-scale natural vegetation gradient. We predicted the biogeographic patterns of soil archaeal, bacterial, and fungal communities across 110 natural forest sites along a transect across four vegetation zones in Eastern China...
January 2017: MSystems
https://www.readbyqxmd.com/read/28190792/whatsapp-doc
#3
Abhijit M Bal
Confidentiality underpins the trust between doctors and patients. As far back as the 2nd century BC, the great Indian physician, Charak, had stated: "Nothing that happens in the house of the sick man must be told outside, nor must the patient's condition be told to anyone who might do harm by that knowledge to the patient or to another".
January 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28190761/prevalence-of-circulating-tumor-cells-after-adjuvant-chemotherapy-with-or-without-anthracyclines-in-patients-with-her2-negative-hormone-receptor-positive-early-breast-cancer
#4
Amelie Schramm, Fabienne Schochter, Thomas W P Friedl, Nikolaus de Gregorio, Ulrich Andergassen, Marianna Alunni-Fabbroni, Elisabeth Trapp, Bernadette Jaeger, Georg Heinrich, Oumar Camara, Thomas Decker, Angelika Ober, Sven Mahner, Tanja N Fehm, Klaus Pantel, Peter A Fasching, Andreas Schneeweiss, Wolfgang Janni, Brigitte K Rack
BACKGROUND: Use of anthracycline-based chemotherapy in patients with early breast cancer (EBC) has been well-established but is often associated with cardiotoxicity. Based on data suggesting a limited benefit of anthracyclines in human epidermal growth factor receptor 2 (HER2)-negative patients, the Simultaneous Study of Docetaxel Based Anthracycline Free Adjuvant Treatment Evaluation, as well as Life Style Intervention Strategies (SUCCESS) C study randomized patients to either anthracycline-containing or anthracycline-free chemotherapy...
January 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28187759/supporting-adherence-to-oral-anticancer-agents-clinical-practice-and-clues-to-improve-care-provided-by-physicians-nurse-practitioners-nurses-and-pharmacists
#5
Lonneke Timmers, Christel C L M Boons, Mathieu Verbrugghe, Bart J F van den Bemt, Ann Van Hecke, Jacqueline G Hugtenburg
BACKGROUND: Healthcare provider (HCP) activities and attitudes towards patients strongly influence medication adherence. The aim of this study was to assess current clinical practices to support patients in adhering to treatment with oral anticancer agents (OACA) and to explore clues to improve the management of medication adherence. METHODS: A cross-sectional, observational study among HCPs in (haemato-)oncology settings in Belgium and the Netherlands was conducted in 2014 using a composite questionnaire...
February 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28187382/adsorption-of-natural-organic-matter-and-disinfection-byproduct-precursors-from-surface-water-on-tio2-nanoparticles-ph-effects-isotherm-modelling-and-implications-for-using-tio2-for-drinking-water-treatment
#6
Stephanie L Gora, Susan A Andrews
Titanium dioxide is a photocatalyst that can remove organic contaminants of interest to the drinking water treatment industry, including natural organic matter (NOM) and disinfection byproduct (DBP) precursors. The photocatalytic reaction occurs in two steps: adsorption of the contaminant followed by degradation of the adsorbed contaminant upon irradiation with UV light. The second part of this process can lead to the formation of reactive intermediates and negative impacts on treated water quality, such as increased DBP formation potential (DBPfp)...
February 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28187348/ferrous-iron-peroxymonosulfate-oxidation-as-a-pretreatment-for-ceramic-ultrafiltration-membrane-control-of-natural-organic-matter-fouling-and-degradation-of-atrazine
#7
Xiaoxiang Cheng, Heng Liang, An Ding, Xiaobin Tang, Bin Liu, Xuewu Zhu, Zhendong Gan, Daoji Wu, Guibai Li
Ferrous iron/peroxymonosulfate (Fe(II)/PMS) oxidation was employed as a pretreatment method for ultrafiltration process to control membrane fouling caused by natural organic matter, including humic acid (HA), sodium alginate (SA), bovine serum albumin (BSA), and their mixture (HA-SA-BSA). To evaluate the mechanism of fouling mitigation, the effects of Fe(II)/PMS pretreatment on the characteristics of feed water were examined. The degradation of atrazine (ATZ) was also investigated and the species of generated radicals were preliminarily determined...
February 1, 2017: Water Research
https://www.readbyqxmd.com/read/28185934/corticosteroids-deeply-depress-the-in-vitro-steroidogenic-capacity-of-eurasian-perch-ovary-at-the-end-of-the-reproductive-cycle
#8
S N M Mandiki, S Milla, S Nkogo Robles, P Kestemont
Corticosteroids play positive or negative role in the reproductive mechanisms of many fish species but the physiological contexts relating to such biphasic actions are not well defined. In the present study we investigated to what extent corticosteroids (cortisol-Co, 11-deoxycorticosterone-DOC) hormones may interfere with the steroidogenic capacity of Eurasian perch follicles, and we tested whether the negative interference of corticosteroids may be mitigated by potential stimulating endocrine factors, namely insulin-like growth factor-1 (IGF), human chorionic gonadotropin (HCG) or thyroid hormones (Triidothyronine-T3, thyroxine-T4)...
February 6, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28185792/randomized-phase-iii-study-of-docetaxel-plus-cisplatin-versus-pemetrexed-plus-cisplatin-as-first-line-treatment-of-nonsquamous-non-small-cell-lung-cancer-a-trail-trial
#9
Cheol-Kyu Park, In-Jae Oh, Kyu-Sik Kim, Yoo-Duk Choi, Tae-Won Jang, Youn-Seup Kim, Kwan-Ho Lee, Kyeong-Cheol Shin, Chi Young Jung, Sei-Hoon Yang, Jeong-Seon Ryu, Seung-Hun Jang, Seung-Soo Yoo, Suk-Joong Yong, Kye Young Lee, Kwang-Ho In, Min-Ki Lee, Young-Chul Kim
INTRODUCTION: To date, no prospective phase III trials have directly compared the efficacy of pemetrexed plus cisplatin (Pem-Cis) with docetaxel plus cisplatin (Doc-Cis) in patients with nonsquamous non-small-cell lung cancer. MATERIALS AND METHODS: A total of 148 chemotherapy-naive patients lacking driver mutations were randomized into 21-day regimens of cisplatin 70 mg/m(2) with either docetaxel 60 mg/m(2) (n = 71) or pemetrexed 500 mg/m(2) (n = 77) for ≤ 4 cycles...
January 11, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28184314/-doc-can-i-fly-to-australia-a-case-report-and-review-of-delirium-following-long-haul-flight
#10
Thomas McCabe
Air travel is now a common feature of most of our elderly population's lives. There is little by way of warnings, rules or recommendations for our patients with psychiatric diagnoses, in particular dementia, who intend to travel by plane, in contrast to other specialties. In this article I highlight an adverse outcome of long-haul air travel as a result of delirium and resulting accelerated decline in overall cognitive function. I review literature related to the topic and suggest ways to minimise precipitating factors for stressors prior to and during flights...
February 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28176365/high-efficacy-of-pazopanib-on-an-undifferentiated-spindle-cell-sarcoma-resistant-to-first-line-therapy-is-identified-with-a-patient-derived-orthotopic-xenograft-pdox-nude-mouse-model
#11
Kentaro Igarashi, Kei Kawaguchi, Takashi Murakami, Tasuku Kiyuna, Kentaro Miyake, Arun S Singh, Scott D Nelson, Sarah Dry, Yunfeng Li, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C Eilber, Robert M Hoffman
Undifferentiated spindle-cell sarcoma (USCS) is a recalcitrant cancer. Our laboratory pioneered the patient-derived orthotopic xenograft (PDOX) nude mouse model with the technique of surgical orthotopic implantation (SOI). In the present study, we evaluated the efficacy of standard first-line chemistry of doxorubicin (DOX), gemcitabine (GEM) combined with docetaxel (DOC), compared to pazopanib (PAZ), a multi-targeting tyrosine-kinase inhibitor, in an USCS PDOX model. A high-grade USCS from a striated muscle of the patients was grown orthotopically in the right biceps femoris muscle of nude mice to establish the PDOX model...
February 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28176154/the-effect-of-wastewater-effluent-derived-ligands-on-copper-and-zinc-complexation
#12
C Constantino, S D W Comber, M D Scrimshaw
The shift toward bioavailability-based standards for metals such as copper and zinc not only improves the ecological relevance of the standard but also introduces significant complexity into assessing compliance. This study examined differences in the copper and zinc complexation characteristics of effluents from a range of different sewage treatment works and in relation to so-called 'natural' samples. This information is essential to determine whether the inclusion of effluent-specific complexation characteristics within the regulatory framework could enhance the environmental relevance of compliance criteria...
February 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28171838/a-comparative-study-of-ozonation-iron-coated-zeolite-catalyzed-ozonation-and-granular-activated-carbon-catalyzed-ozonation-of-humic-acid
#13
Dilek Gümüş, Feryal Akbal
This study compares ozonation (O3), iron coated zeolite catalyzed ozonation (ICZ-O3) and granular activated carbon catalyzed ozonation (GAC-O3) for removal of humic acid from an aqueous solution. The results were evaluated by the removal of DOC that specifies organic matter, UV254 absorbance, SUVA (Specific Ultraviolet Absorbance at 254 nm) and absorbance at 436 nm. When ozonation was used alone, DOC removal was 21.4% at an ozone concentration of 10 mg/L, pH 6.50 and oxidation time of 60 min. The results showed that the use of ICZ or GAC as a catalyst increased the decomposition of humic acid compared to ozonation alone...
January 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28169083/evaluation-of-biochar-amended-biosolids-co-composting-to-improve-the-nutrient-transformation-and-its-correlation-as-a-function-for-the-production-of-nutrient-rich-compost
#14
Mukesh Kumar Awasthi, Quan Wang, Hongyu Chen, Meijing Wang, Xiuna Ren, Junchao Zhao, Jiao Li, Di Guo, Dong-Sheng Li, Sanjeev Kumar Awasthi, Xining Sun, Zengqiang Zhang
The influence of biochar amended dewatered fresh sewage sludge (DFSS)-wheat straw co-composting on nutrients transformation and end products quality was investigated. This is the first study to examine the biochar applied compost quality with different kgha(-1) TKN on Brassica rapa L. growth. Seven mixtures were composted over 8-weeks period in 130-L reactor using the same DFSS with different concentration of biochar (2%, 4%, 6%, 8%, 12% and 18% on dry weight basis) and without additive added treatment served as control...
January 26, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28168390/supramolecular-chitosan-micro-platelets-synergistically-enhance-anti-candida-albicans-activity-of-amphotericin-b-using-an-immunocompetent-murine-model
#15
Tiphany Grisin, Christian Bories, Martina Bombardi, Philippe M Loiseau, Valérie Rouffiac, Audrey Solgadi, Jean-Maurice Mallet, Gilles Ponchel, Kawthar Bouchemal
PURPOSE: The aim of this work is to design new chitosan conjugates able to self-organize in aqueous solution in the form of micrometer-size platelets. When mixed with amphotericin B deoxycholate (AmB-DOC), micro-platelets act as a drug booster allowing further improvement in AmB-DOC anti-Candida albicans activity. METHODS: Micro-platelets were obtained by mixing oleoyl chitosan and α-cyclodextrin in water. The formulation is specifically-engineered for mucosal application by dispersing chitosan micro-platelets into thermosensitive pluronic(®) F127 20 wt% hydrogel...
February 6, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28167408/thm-and-haa-formation-from-nom-in-raw-and-treated-surface-waters
#16
D M Golea, A Upton, P Jarvis, G Moore, S Sutherland, S A Parsons, S J Judd
The disinfection by-product (DBP) formation potential (FP) of natural organic matter (NOM) in surface water sources has been studied with reference to the key water quality determinants (WQDs) of UV absorption (UV254), colour, and dissolved organic carbon (DOC) concentration. The data set used encompassed raw and treated water sampled over a 30-month period from 30 water treatment works (WTWs) across Scotland, all employing conventional clarification. Both trihalomethane (THM) and haloacetic acid (HAA) FPs were considered...
January 29, 2017: Water Research
https://www.readbyqxmd.com/read/28163026/engineering-of-cyp106a2-for-steroid-9%C3%AE-and-6%C3%AE-hydroxylation
#17
Julia Nikolaus, Kim Thoa Nguyen, Cornelia Virus, Jan L Riehm, Michael Hutter, Rita Bernhardt
CYP 106A2 from Bacillus megaterium ATCC 13368 has been described as a 15β-hydroxylase showing also minor 11α-, 9α- and 6β-hydroxylase activity for progesterone conversion. Previously, mutant proteins with a changed selectivity towards 11α-OH-progesterone have already been produced. The challenge of this work was to create mutant proteins with a higher regioselectivity towards hydroxylation at positions 9 and 6 of the steroid molecule. 9α-hydroxyprogesterone exhibits pharmaceutical importance, because it is a useful intermediate in the production of physiologically active substances which possess progestational activity...
February 2, 2017: Steroids
https://www.readbyqxmd.com/read/28162250/effects-of-anthropogenic-surfactants-on-the-conversion-of-marine-dissolved-organic-carbon-and-microgels
#18
Ruei-Feng Shiu, Chon-Lin Lee
The possible impact of three types of anthropogenic surfactants on the ability of marine dissolved organic carbon (DOC) to form self-assembled microgels was evaluated. The behavior of existing native microgels was also examined in the presence of surfactants. These results reveal that the release of surfactants even at low concentrations into the aquatic environment could effectively hinder the self-assembly of DOC polymers. The extent of the size reduction had the following order: anionic, cationic, and non-ionic...
February 2, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28160751/pain-perception-in-patients-with-chronic-disorders-of-consciousness-what-can-limbic-system-tell-us
#19
Rocco Salvatore Calabrò, Antonino Naro, Alfredo Manuli, Antonino Leo, Rosaria De Luca, Viviana Lo Buono, Margherita Russo, Alessia Bramanti, Placido Bramanti
OBJECTIVE: Although it is believed that patients with Unresponsive Wakefulness Syndrome (UWS) do not feel pain, recent neuroimaging and neurophysiologic studies have demonstrated some residual traces of nociceptive processing. METHODS: To confirm this growing evidence, we evaluated 21 patients suffering from chronic disorders of consciousness (DOC) (both UWS, n=11, and Minimally Conscious State - MCS -, n=10), using an Event-Related Potential (ERP) Low-Resolution Brain Electromagnetic Tomography (LORETA) approach, based on nociceptive repeated laser stimulation (RLS)...
December 29, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28160641/contribution-of-glomalin-to-dissolve-organic-carbon-under-different-land-uses-and-seasonality-in-dry-tropics
#20
Ashutosh Kumar Singh, Apurva Rai, Vivek Pandey, Nandita Singh
Glomalin related soil protein (GRSP) is a hydrophobic glycoprotein that is significant for soil organic carbon (SOC) persistence and sequestration, owing to its large contribution to SOC pool and long turnover time. However, the contribution of GRSP to dissolve OC (DOC) leach from soil is not yet comprehensively explored, though it could have implication in understanding SOC dynamics. We, therefore, aim to measure the contribution of GRSP to DOC, in a range of land uses and climatic seasons in the dry tropical ecosystem...
February 1, 2017: Journal of Environmental Management
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