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https://www.readbyqxmd.com/read/29147694/emerging-investigator-series-the-effect-of-wildfire-on-streamwater-mercury-and-organic-carbon-in-a-forested-watershed-in-the-southeastern-united-states
#1
Allison M Jensen, Todd M Scanlon, Ami L Riscassi
Wildfires alter forested ecosystems, which include large stores of mercury (Hg) and organic carbon, two compounds that are closely linked in vegetation, soils, and streamwater. Studies have shown that wildfires release elevated levels of mercury to the atmosphere which can be locally redeposited and leave charred organic material (vegetation and litter) on the soil surface. Both can contribute to the elevated mobilization of Hg into lakes and streams. However, no studies have conducted a detailed examination of hydrological transport of Hg following a wildfire...
November 17, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29146962/microbial-communities-in-the-native-habitats-of-agaricus-sinodeliciosus-from-xinjiang-province-revealed-by-amplicon-sequencing
#2
Jiemin Zhou, Xuming Bai, Ruilin Zhao
Agaricus sinodeliciosus is an edible species described from China and has been successfully cultivated. However, no studies have yet reported the influence factors implicated in the process of fructification. To better know abiotic and biotic factors, physiochemical characteristics and microbial communities were investigated in five different soil samples collected in the native habitats of specimens from northern Xinjiang, southern Xinjiang, and Zhejiang Province, respectively. There are major differences in texture and morphology among different specimens of A...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29144824/17%C3%AE-hydroxylase-deficiency-is-an-underdiagnosed-disease-high-frequency-of-misdiagnoses-in-a-large-cohort-of-brazilian-patients
#3
Rafaela Fontenele, Marivânia Costa-Santos, Claudio E Kater
OBJECTIVE: 17α-Hydroxylase deficiency (P450c17D) is characterized by hypogonadism and mineralocorticoid hypertension. We aimed to estimate the relative incidence and spectrum of preliminary misdiagnoses in Brazilian P450c17D patients. DESIGN: Cross-sectional study. METHODS: We reviewed, updated, and analyzed data of 40 P450c17D patients (21 XY, 19 XX). RESULTS: Complete data were unavailable for two patients. Seven patients were relatives of an index case...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29143983/growth-of-doxorubicin-resistant-undifferentiated-spindle-cell-sarcoma-pdox-is-arrested-by-metabolic-targeting-with-recombinant-methioninase
#4
Kentaro Igarashi, Shukuan Li, Qinghong Han, Yuying Tan, Kei Kawaguchi, Takashi Murakami, Tasuku Kiyuna, Kentaro Miyake, Yunfeng Li, Scott D Nelson, Sarah M Dry, Arun S Singh, Irmina A Elliott, Tara A Russell, Mark A Eckardt, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C Eilber, Robert M Hoffman
Undifferentiated spindle-cell sarcoma (USCS) is a recalcitrant -cancer in need of individualized therapy. A high-grade USCS from a striated muscle of a patient was grown orthotopically in the right biceps femoris muscle of nude mice to establish a patient-derived orthotopic xenograft (PDOX) model. In a previous study, we evaluated the efficacy of standard first-line chemotherapy of doxorubicin (DOX), gemcitabine (GEM) combined with docetaxel (DOC), compared to pazopanib (PAZ), a multi-targeting tyrosine-kinase inhibitor, in an USCS PDOX model...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29143257/environmental-characteristics-and-changes-of-sediment-pore-water-dissolved-organic-matter-in-four-chinese-lakes
#5
Khan M G Mostofa, Wen Li, Fengchang Wu, Cong-Qiang Liu, Haiqing Liao, Li Zeng, Min Xiao
Sediment pore waters were examined in four Chinese lakes (Bosten, Qinghai, Chenghai and Dianchi) to characterise the sources of dissolved organic matter (DOM) and their microbial changes in the sediment depth profiles. Parallel factor (PARAFAC) modelling on the sample fluorescence spectra confirmed that the pore water DOM was mostly composed of two components with a mixture of both allochthonous and autochthonous fulvic acid-like substances in three lakes, except Lake Dianchi, and protein-like components in Lake Bosten...
November 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29138382/-a-case-of-retroperitoneal-abscess-due-to-acute-appendicitis-during-neo-adjuvant-chemotherapy-for-breast-cancer
#6
Takaaki Oba, Kazuma Maeno, Kenichi Ito, Satoshi Ishizone, Takaomi Hanaoka
When acute appendicitis occurs in patients treated with chemotherapy, neutropenia and abdominal complaints caused by chemotherapy can contribute to the diagnostic difficulty, masking the increase in white blood cell(WBC)counts and physical findings of acute appendicitis. A 43-year-old premenopausal woman who was diagnosed with stage IIIA left breast cancer was scheduled for neoadjuvant chemotherapy includingfluorouracil plus epirubicin plus cyclophosphamide(FEC), followed by docetaxel and trastuzumab(DOC plus HER)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29134812/deoxycholate-enhanced-shigella-virulence-is-regulated-by-a-rare-%C3%AF-helix-in-the-type-three-secretion-system-tip-protein-ipad
#7
Abram R Bernard, T Carson Jessop, Prashant Kumar, Nicholas E Dickenson
Type three secretion systems (T3SS) are specialized nano-machines that support infection by injecting bacterial proteins directly into host cells. The Shigella T3SS has uniquely evolved to sense environmental levels of the bile salt deoxycholate (DOC) and up-regulate virulence in response to DOC. In this study, we describe a rare i+5 hydrogen bonding secondary structure element (π-helix) within the type three secretion system tip protein IpaD that plays a critical role in DOC-enhanced virulence. Specifically, engineered mutations within the π-helix altered the pathogen's response to DOC with one mutant construct in particular exhibiting an unprecedented reduction in virulence following DOC exposure...
November 14, 2017: Biochemistry
https://www.readbyqxmd.com/read/29134572/doc-i-just-ate-interpreting-random-blood-glucose-values-in-patients-with-unknown-glycemic-status
#8
Michael E Bowen, Lei Xuan, Ildiko Lingvay, Ethan A Halm
No abstract text is available yet for this article.
November 13, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29132208/organic-chemical-characterization-and-mass-balance-of-a-hydraulically-fractured-well-from-fracturing-fluid-to-produced-water-over-405-days
#9
James S Rosenblum, E Michael Thurman, Imma Ferrer, George R Aiken, Karl G Linden
A long-term field study (405 days) of a hydraulically fractured well from the Niobrara Formation in the Denver-Julesburg Basin was completed. Characterization of organic chemicals used in hydraulic fracturing and their changes through time, from the pre-injected fracturing fluid to the produced water, was conducted. The characterization consisted of a mass balance by dissolved organic carbon (DOC), volatile organic analysis by gas chromatography/mass spectrometry, and nonvolatile organic analysis by liquid chromatography/mass spectrometry...
November 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29128822/a-doc-coagulant-gypsum-treatment-can-simultaneously-reduce-as-cd-and-pb-uptake-by-medicinal-plants-grown-in-contaminated-soil
#10
Hyuck Soo Kim, Byoung-Hwan Seo, Saranya Kuppusamy, Yong Bok Lee, Jae-Hwang Lee, Jae-E Yang, Gary Owens, Kwon-Rae Kim
The efficiency of gypsum, as a dissolved organic carbon (DOC) coagulator, for the simultaneous immobilization of two heavy metals (Cd and Pb) and one metalloid (As) in agricultural soils near an abandoned mining site was examined. The agricultural soil was defined as long-term contaminated as As (1540mgkg(-1)), Cd (55mgkg(-1)) and Pb (1283mgkg(-1)) concentrations exceeded the Korean guideline values for As (25mgkg(-1)), Cd (4mgkg(-1)), and Pb (200mgkg(-1)). Gypsum was incorporated into the contaminated soil at 3% (w/w)...
November 9, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29128766/low-biodegradability-of-dissolved-organic-matter-and-trace-metals-from-subarctic-waters
#11
Olga V Oleinikova, Liudmila S Shirokova, Olga Y Drozdova, Sergey A Lapitskiy, Oleg S Pokrovsky
The heterotrophic mineralization of dissolved organic matter (DOM) controls the CO2 flux from the inland waters to the atmosphere, especially in the boreal waters, although the mechanisms of this process and the fate of trace metals associated with DOM remain poorly understood. We studied the interaction of culturable aquatic (Pseudomonas saponiphila) and soil (Pseudomonas aureofaciens) Gammaproteobacteria with seven different organic substrates collected in subarctic settings. These included peat leachate, pine crown throughfall, fen, humic lake, stream, river, and oligotrophic lake with variable dissolved organic carbon (DOC) concentrations (from 4 to 60mgL(-1))...
November 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29128122/resilience-of-carbon-and-nitrogen-removal-due-to-aeration-interruption-in-aerated-treatment-wetlands
#12
Johannes Boog, Jaime Nivala, Thomas Aubron, Sibylle Mothes, Manfred van Afferden, Roland A Müller
Treatment wetlands have long been used for domestic and industrial wastewater treatment. In recent decades, treatment wetland technology has evolved and now includes intensified designs such as aerated treatment wetlands. Aerated treatment wetlands are particularly dependent on aeration, which requires reliable air pumps and, in most cases, electricity. Whether aerated treatment wetlands are resilient to disturbances such as an aeration interruption is currently not well known. In order to investigate this knowledge gap, we carried out a pilot-scale experiment on one aerated horizontal flow wetland and one aerated vertical flow wetland under warm (Twater>17°C) and cold (Twater<10°C) weather conditions...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29128120/effects-of-agricultural-land-use-on-dissolved-organic-carbon-and-nitrogen-in-surface-runoff-and-subsurface-drainage
#13
Noora Manninen, Helena Soinne, Riitta Lemola, Laura Hoikkala, Eila Turtola
Dissolved organic carbon (DOC) load in discharges from cultivated soils may have negative impacts on surface waters. The magnitude of the load may vary according to soil properties or agricultural management practices. This study quantifies the DOC load of cultivated mineral soils and investigates whether the load is affected by agricultural practices. Discharge volumes and concentrations of DOC and dissolved organic nitrogen (DON) were continually measured at three sites from surface runoff and artificial subsurface drainage or from combined total discharge over a two-year period (2012-2014)...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29127801/the-potential-of-chironomid-larvae-based-metrics-in-the-bioassessment-of-non-wadeable-rivers
#14
Djuradj Milošević, Dejan Mančev, Dubravka Čerba, Milica Stojković Piperac, Nataša Popović, Ana Atanacković, Jelena Đuknić, Vladica Simić, Momir Paunović
The chironomid community in non-wadeable lotic systems was tested as a source of information in the construction of biological metrics which could be used into the bioassessment protocols of large rivers. In order to achieve this, we simultaneously patterned the chironomid community structure and environmental factors along the catchment of the Danube and Sava River. The Self organizing map (SOM) recognized and visualized three different structural types of chironomid community for different environmental properties, described by means of 7 significant abiotic factors (a multi-stressor gradient)...
November 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29123399/multifunctional-gold-nanorods-and-docetaxel-encapsulated-liposomes-for-combined-thermo-and-chemotherapy
#15
Haiying Hua, Nan Zhang, Dan Liu, Lili Song, Tuanbing Liu, Shasha Li, Yongxing Zhao
Personalized and precise nanomedicines are highly demanded for today's medical needs. Liposomes are ideal candidates for the construction of multifunctional drug delivery systems. In this study, a liposome was used to improve the clinical issues of docetaxel (Doc), a potent antimitotic chemotherapy for prostate cancer (PC). RLT, a low-density lipoprotein receptor (LDLR)-binding peptide, and PEG were conjugated to the liposomes, and gold nanorods (GNRs) were also incorporated into the liposomes. The GNRs/Doc-liposome-RLT (GNRs/DocL-R) was tested in PC-3 cells and in PC-3 tumor-bearing nude mice...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29116985/resources-used-to-teach-the-physical-exam-to-preclerkship-medical-students-results-of-a-national-survey
#16
Toshiko Uchida, Francis I Achike, Angela D Blood, Mary Boyle, Jeanne M Farnan, Deepthiman Gowda, Joanne Hojsak, Robin K Ovitsh, Yoon Soo Park, Ronald Silvestri
PURPOSE: To examine the resources utilized in teaching the physical exam to preclerkship students at U.S. medical schools. METHOD: The Directors of Clinical Skills Courses (DOCS) developed a 49-question survey addressing the resources and pedagogical methods employed in preclerkship physical exam curricula. The survey was sent to all 141 LCME-accredited medical schools in October 2015. Results were averaged across schools and data were weighted by class size. RESULTS: Results from 106 medical schools (75% response rate) identified a median of 59 hours devoted to teaching the physical exam...
November 7, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29112920/performance-evaluation-of-a-biodiesel-fuelled-transportation-engine-retrofitted-with-a-non-noble-metal-catalysed-diesel-oxidation-catalyst-for-controlling-unregulated-emissions
#17
Pravesh Chandra Shukla, Tarun Gupta, Avinash Kumar Agarwal
In present study, engine exhaust was sampled for measurement and analysis of unregulated emissions from a four cylinder transportation diesel engine using a state-of-the-art FTIR (Fourier transform infrared spectroscopy) emission analyzer. Test fuels used were Karanja biodiesel blend (B20) and baseline mineral diesel. Real-time emission measurements were performed for raw exhaust as well as exhaust sampled downstream of the two in-house prepared non-noble metal based diesel oxidation catalysts (DOCs) and a baseline commercial DOC based on noble metals...
October 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29112416/redox-conditions-affect-dissolved-organic-carbon-quality-in-stratified-freshwaters
#18
Tallent Dadi, Mourad Harir, Norbert Hertkorn, Matthias Koschorreck, Philippe Schmitt-Kopplin, Peter Herzsprung
The quality of dissolved organic carbon (DOC) affects both carbon cycling in surface waters and drinking water production. Not much is known about the influence of environmental conditions on DOC quality. We studied the effect of redox conditions on the chemical composition of DOC in a drinking water reservoir by Fourier transform ion cyclotron resonance mass spectrometry in combination with sediment core incubation experiments under manipulated redox conditions. We observed clear differences in DOC quality among oxic epilimnion, anoxic hypolimnion, and sediment porewater...
November 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29107594/genes-associated-with-pancreas-development-and-function-maintain-open-chromatin-in-ipscs-generated-from-human-pancreatic-beta-cells
#19
Matthias Thurner, Liraz Shenhav, Agata Wesolowska-Andersen, Amanda J Bennett, Amy Barrett, Anna L Gloyn, Mark I McCarthy, Nicola L Beer, Shimon Efrat
Current in vitro islet differentiation protocols suffer from heterogeneity and low efficiency. Induced pluripotent stem cells (iPSCs) derived from pancreatic beta cells (BiPSCs) preferentially differentiate toward endocrine pancreas-like cells versus those from fibroblasts (FiPSCs). We interrogated genome-wide open chromatin in BiPSCs and FiPSCs via ATAC-seq and identified ∼8.3k significant, differential open chromatin sites (DOCS) between the two iPSC subtypes (false discovery rate [FDR] < 0.05). DOCS where chromatin was more accessible in BiPSCs (Bi-DOCS) were significantly enriched for known regulators of endodermal development, including bivalent and weak enhancers, and FOXA2 binding sites (FDR < 0...
November 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29102844/dynamics-of-dissolved-organic-matter-dom-in-a-typical-inland-lake-of-the-three-gorges-reservoir-area-fluorescent-properties-and-their-implications-for-dissolved-mercury-species
#20
Tao Jiang, Xueshuang Chen, Dingyong Wang, Jian Liang, Weiyang Bai, Cheng Zhang, Qilei Wang, Shiqiang Wei
Dissolved organic matter (DOM) plays an important environmental and ecological role in inland aquatic systems, including lakes. In this study, using fluorescence analysis, we investigated the seasonal dynamics of DOM characteristics in Changshou Lake, which is a typical inland lake in the Three Gorges Reservoir (TGR) area. We also discuss the environmental implications of DOM for mercury (Hg) dynamics. Based on the origins of two end-members, the variations in DOM observed in this study in Changshou Lake suggest that hydrological processes (e...
November 2, 2017: Journal of Environmental Management
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