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https://www.readbyqxmd.com/read/29618945/inducers-of-senescence-toxic-compounds-and-senolytics-the-multiple-faces-of-nrf2-activating-phytochemicals-in-cancer-adjuvant-therapy
#1
REVIEW
Marco Malavolta, Massimo Bracci, Lory Santarelli, Md Abu Sayeed, Elisa Pierpaoli, Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Maurizio Cardelli, Mauro Provinciali
The reactivation of senescence in cancer and the subsequent clearance of senescent cells are suggested as therapeutic intervention in the eradication of cancer. Several natural compounds that activate Nrf2 (nuclear factor erythroid-derived 2-related factor 2) pathway, which is involved in complex cytoprotective responses, have been paradoxically shown to induce cell death or senescence in cancer. Promoting the cytoprotective Nrf2 pathway may be desirable for chemoprevention, but it might be detrimental in later stages and advanced cancers...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29607689/curcumin-and-resveratrol-rescue-cortical-hippocampal-system-from-chronic-fluoride-induced-neurodegeneration-and-enhance-memory-retrieval
#2
Chhavi Sharma, Pooja Suhalka, Maheep Bhatnagar
OBJECTIVE: The aim of this study were: (1) To evaluate neuroprotective effect of Resveratrol and Curcumin on NADPH-d (Nicotinamide adenine dinucleotide phosphate diaphorase) activity in neuronal cell in sub regions of mice brain (2) To evaluate the effects on antioxidant status, and (3) To evaluate the protective effects of phytochemicals on learning and memory following fluoride exposure. METHOD: Young Mice (one month old, B.W. 30±5mg) were provided to 120 ppm sodium fluoride dissolved in drinking water...
April 2, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29602908/a-review-of-promising-natural-chemopreventive-agents-for-head-and-neck-cancer
#3
Kyle Crooker, Rana Aliani, Megha Ananth, Levi Arnold, Shrikant Anant, Sufi Mary Thomas
Head and neck squamous cell carcinoma (HNSCC) accounts for 300,000 deaths per year worldwide and overall survival rates have shown little improvement over the past three decades. Current treatment methods including surgery, chemotherapy, and radiotherapy leave patients with secondary morbidities. Thus, treatment of HNSCC may benefit from exploration of natural compounds as chemopreventive agents. With excellent safety profiles, reduced toxicities, antioxidant properties, and general acceptance for use as dietary supplements, natural compounds are viewed as a desirable area of investigation for chemoprevention...
March 30, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29589094/impact-of-dietary-compounds-on-cancer-related-gut-microbiota-and-microrna
#4
REVIEW
Muhammad Shahid Riaz Rajoka, Mingliang Jin, Zhao Haobin, Qi Li, Dongyan Shao, Qingsheng Huang, Junling Shi
Cancer is one of the most common causes of death worldwide. Extensive research has been conducted on cancer; regardless, the link between cancer and diet remains undetermined. Recent studies have emphasized the importance of miRNAs in cancer-associated pathways from the perspective of dietary modulation. We highlighted the recent data on dietary modulation of gut microbiota and miRNAs related to cancer on the basis of recently published results. The targets of miRNAs are oncogenes or tumor suppressors that mediate the progression and initiation of carcinogenesis...
March 27, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29546309/supplementation-with-resveratrol-and-curcumin-does-not-affect-the-inflammatory-response-to-a-high-fat-meal-in-older-adults-with-abdominal-obesity-a-randomized-placebo-controlled-crossover-trial
#5
Cécile Vors, Charles Couillard, Marie-Eve Paradis, Iris Gigleux, Johanne Marin, Marie-Claude Vohl, Patrick Couture, Benoît Lamarche
Background: High-fat meals induce postprandial inflammation. Resveratrol is a polyphenol known to prevent comorbidities associated with cardiovascular disease and exerts an anti-inflammatory action. There is also an increasing body of evidence supporting the role of curcumin, a polyphenol from the curcuminoid family, as a modulator of proinflammatory processes. Objective: The objectives of this study were to investigate the following: 1) the bioavailability of resveratrol consumed in combination with curcumin after consumption of a high-fat meal; and 2) the acute combined effects of this combination on the postprandial inflammatory response of subjects with abdominal obesity...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29501629/synthetic-resveratrol-curcumin-hybrid-derivative-inhibits-mitosis-progression-in-estrogen-positive-mcf-7-breast-cancer-cells
#6
Matheus de Freitas Silva, Letícia Ferreira Coelho, Isadora Mitestainer Guirelli, Rodrigo Machado Pereira, Guilherme Álvaro Ferreira da Silva, Graciana Y Graravelli, Renato de Oliveira Horvath, Ester Siqueira Caixeta Nogueira, Marisa Ionta, Claudio Viegas
Curcumin (1) and resveratrol (2) are bioactive natural compounds that display wide pharmacological properties, including antitumor activity. However, their clinical application has been limited due to their low solubility and bioavailability. Nevertheless, independent studies have considered these compounds as interesting prototypes for developing new chemical structures useful for anticancer therapy. Here in, we report the synthesis of novel curcumin-like hydrazide analogues (3a and 3b), and a series of curcumin-resveratrol hybrid compounds (4a-f), and the evaluation of their cytotoxic potential on three tumor cell lines MCF-7 (breast), A549 (lung), and HepG2 (liver)...
March 1, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29453519/tricurin-a-synergistic-formulation-of-curcumin-resveratrol-and-epicatechin-gallate-repolarizes-tumor-associated-macrophages-and-triggers-an-immune-response-to-cause-suppression-of-hpv-tumors
#7
Sumit Mukherjee, Rahman Hussaini, Richard White, Doaa Atwi, Angela Fried, Samay Sampat, Longzhu Piao, Quintin Pan, Probal Banerjee
Our earlier studies reported a unique potentiated combination (TriCurin) of curcumin (C) with two other polyphenols. The TriCurin-associated C displays an IC50 in the low micromolar range for cultured HPV+ TC-1 cells. In contrast, because of rapid degradation in vivo, the TriCurin-associated C reaches only low nano-molar concentrations in the plasma, which are sub-lethal to tumor cells. Yet, injected TriCurin causes a dramatic suppression of tumors in TC-1 cell-implanted mice (TC-1 mice) and xenografts of Head and Neck Squamous Cell Carcinoma (HNSCC) cells in nude/nude mice...
February 16, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29436058/effects-of-a-standard-american-diet-and-an-anti-inflammatory-diet-in-male-and-female-mice
#8
S K Totsch, R Y Meir, T L Quinn, S A Lopez, B A Gower, R E Sorge
SIGNIFICANCE: Obesity may increase susceptibility to chronic pain often due to poor diet. Diet has potential to be used as treatment for pain. The current study investigates the use of a novel translatable diet to act as a preventative (i.e., prior to surgery) or an intervention (i.e., following an injury). BACKGROUND: Obesity and chronic pain are prevalent concerns. Pain is frequently experienced in weight bearing joints, but is common in other areas of the body as well, suggesting other factors...
February 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29378496/nutraceuticals-to-promote-neuronal-plasticity-in-response-to-corticosterone-induced-stress-in-human-neuroblastoma-cells
#9
Snehal Gite, R Paul Ross, Dara Kirke, Freddy Guihéneuf, Justine Aussant, Dagmar B Stengel, Timothy G Dinan, John F Cryan, Catherine Stanton
OBJECTIVES: To search for novel compounds that will protect neuronal cells under stressed conditions that may help to restore neuronal plasticity. METHODS: A model of corticosterone (CORT)-induced stress in human neuroblastoma cells (SH-SY5Y) was used to compare the efficacy of 6 crude extracts and 10 pure compounds (6 polyphenols, 2 carotenoids, 1 amino acid analogue, and 1 known antidepressant drug) to increase neuronal plasticity and to decrease cytotoxicity...
January 29, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29361877/pharmacological-review-on-asiatic-acid-and-its-derivatives-a-potential-compound
#10
Junwei Lv, Alok Sharma, Ting Zhang, Yuchen Wu, Xianting Ding
Natural triterpenes represent a group of pharmacologically active and structurally diverse organic compounds. The focus on these phytochemicals has been enormous in the past few years, worldwide. Asiatic acid (AA), a naturally occurring pentacyclic triterpenoid, is found mainly in the traditional medicinal herb Centella asiatica. Triterpenoid saponins, which are the primary constituents of C. asiatica, are commonly believed to be responsible for their extensive therapeutic actions. Published research work has described the molecular mechanisms underlying the various biological activities of AA and its derivatives, which vary for each chronic disease...
April 2018: SLAS Technology
https://www.readbyqxmd.com/read/29346317/liposomal-tricurin-a-synergistic-combination-of-curcumin-epicatechin-gallate-and-resveratrol-repolarizes-tumor-associated-microglia-macrophages-and-eliminates-glioblastoma-gbm-and-gbm-stem-cells
#11
Sumit Mukherjee, Juliet N E Baidoo, Samay Sampat, Andrew Mancuso, Lovena David, Leah S Cohen, Shuiqin Zhou, Probal Banerjee
Glioblastoma (GBM) is a deadly brain tumor with a current mean survival of 12-15 months. Despite being a potent anti-cancer agent, the turmeric ingredient curcumin (C) has limited anti-tumor efficacy in vivo due to its low bioavailability. We have reported earlier a strategy involving the use two other polyphenols, epicatechin gallate (E) from green tea and resveratrol (R) from red grapes at a unique, synergistic molar ratio with C (C:E:R: 4:1:12.5, termed TriCurin) to achieve superior potency against HPV+ tumors than C alone at C:E:R (μM): 32:8:100 (termed 32 μM+ TriCurin)...
January 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29332583/eating-green-shining-light-on-the-use-of-dietary-phytochemicals-as-a-modern-approach-in-the-prevention-and-treatment-of-head-and-neck-cancers
#12
Linda L Eastham, Candace M Howard, Premalatha Balachandran, David S Pasco, Pier Paolo Claudio
Enthusiasm for the use of dietary bioactive compounds as chemopreventive agents and adjuvants for current therapies has increased laboratory research conducted on several types of cancers including Head and Neck Squamous Cell Carcinoma (HNSCC). The green chemoprevention movement is a modern approach to highlight healthy lifestyle changes that aim to decrease the incidence of HNSCC. A healthy diet can be an effective way to prevent the development of oral cancers. Discovery of the naturally occurring plant based compounds called phytochemicals has facilitated the development of new treatment strategies for patients that are at risk for, or have developed HNSCC...
January 12, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29316620/could-aspirin-and-diets-high-in-fiber-act-synergistically-to-reduce-the-risk-of-colon-cancer-in-humans
#13
REVIEW
Pan Pan, Yi-Wen Huang, Kiyoko Oshima, Martha Yearsley, Jianying Zhang, Jianhua Yu, Mark Arnold, Li-Shu Wang
Early inhibition of inflammation suppresses the carcinogenic process. Aspirin is the most commonly used non-steroid anti-inflammatory drugs (NSAIDs), and it irreversibly inhibits cyclooxygenase-1 and -2 (COX1, COX2). Multiple randomized clinical trials have demonstrated that aspirin offers substantial protection from colon cancer mortality. The lower aspirin doses causing only minimal gastrointestinal disturbance, ideal for long-term use, can achieve only partial and transitory inhibition of COX2. Aspirin's principal metabolite, salicylic acid, is also found in fruits and vegetables that inhibit COX2...
January 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29289576/botanicals-and-phytochemicals-active-on-cognitive-decline-the-clinical-evidence
#14
REVIEW
Arrigo F G Cicero, Federica Fogacci, Maciej Banach
Beyond the well-known effects on cognitive impairment of the Mediterranean diet, a number of studies have investigated the possible action on cognitive decline of different botanicals and phytochemicals, most of which are well-known anti-inflammatory or antioxidant agents with a good tolerability and safety profile. In particular, the current literature supports the use of Ginkgo biloba, resveratrol, epigallocatechin-3-gallate and l-theanine, Theobroma cacao, Bacopa monnieri, Crocus sativus and curcumin, which might have a positive impact on cognitive impairment used alone or in combination with other nutraceuticals or traditional drugs...
December 28, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29234485/regulation-of-sirtuin-mediated-protein-deacetylation-by-cardioprotective-phytochemicals
#15
REVIEW
Niria Treviño-Saldaña, Gerardo García-Rivas
Modulation of posttranslational modifications (PTMs), such as protein acetylation, is considered a novel therapeutic strategy to combat the development and progression of cardiovascular diseases. Protein hyperacetylation is associated with the development of numerous cardiovascular diseases, including atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. In addition, decreased expression and activity of the deacetylases Sirt1, Sirt3, and Sirt6 have been linked to the development and progression of cardiac dysfunction...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29207192/resveratrol-attenuates-hydrogen-peroxide%C3%A2-induced-apoptosis-reactive-oxygen-species-generation-and-psgl%C3%A2-1-and-vwf-activation-in-human-umbilical-vein-endothelial-cells-potentially-via-mapk-signalling-pathways
#16
Zhenkai Lou, Xingguo Li, Xueling Zhao, Kaili Du, Xing Li, Bing Wang
Reactive oxygen species (ROS) are implicated in the pathogenesis of thrombosis. Studies have reported that resveratrol exhibits antioxidative activities, however, the effect and underlying mechanisms of resveratrol on venous thrombosis remain largely unknown. To investigate the effect of resveratrol on venous thrombosis and the underlying mechanisms, the present study investigated the effects of resveratrol on cell viability, apoptosis, ROS generation and the expression of thrombosis‑associated markers in human umbilical vein endothelial cells (HUVECs)...
February 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29202102/combinatorial-treatment-with-natural-compounds-in-prostate-cancer-inhibits-prostate-tumor-growth-and-leads-to-key-modulations-of-cancer-cell-metabolism
#17
Alessia Lodi, Achinto Saha, Xiyuan Lu, Bo Wang, Enrique Sentandreu, Meghan Collins, Mikhail G Kolonin, John DiGiovanni, Stefano Tiziani
High-throughput screening of a natural compound library was performed to identify the most efficacious combinatorial treatment on prostate cancer. Ursolic acid, curcumin and resveratrol were selected for further analyses and administered in vivo via the diet, either alone or in combination, in a mouse allograft model of prostate cancer. All possible combinations of these natural compounds produced synergistic effects on tumor size and weight, as predicted in the screens. A subsequent untargeted metabolomics and metabolic flux analysis using isotopically labeled glutamine indicated that the compound combinations modulated glutamine metabolism...
2017: NPJ Precision Oncology
https://www.readbyqxmd.com/read/29197967/effects-of-nutraceuticals-on-anaplastic-thyroid-cancer-cells
#18
Lorenzo Allegri, Francesca Rosignolo, Catia Mio, Sebastiano Filetti, Federica Baldan, Giuseppe Damante
PURPOSE: The anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a high mortality rate. Since nutraceuticals may exert beneficial effects on tumor biology, here, effects of four of these compounds [resveratrol, genistein, curcumin and epigallocatechin-3-gallate (EGCG)] on ATC cell lines were investigated. METHODS: Two ATC-derived cell lines were used: SW1736 and 8505C. Cell viability and in vitro aggressiveness was tested by MTT and soft agar assays...
February 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29183770/nutraceuticals-an-emerging-therapeutic-approach-against-the-pathogenesis-of-alzheimer-s-disease
#19
REVIEW
Pritam Sadhukhan, Sukanya Saha, Sayanta Dutta, Sushweta Mahalanobish, Parames C Sil
Alzheimer's disease (AD) is regarded as a progressive and devastating neurodegenerative disorder. In aged individuals, it is the most prevalent cause of dementia and is characterized by gradual loss of cognitive functions. In the last decade, numerous research works were undertaken to investigate the pathogenesis of AD. Although the etiology of AD is still not clear, several histopathological studies confirm prominent changes in the AD affected brains. The major changes include the formation of senile plaques and neurofibrillary tangles primarily owing to the deposition of amyloid β plaques (Aβ) and hyper-phosphorylation of tau protein...
March 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29179999/phytochemicals-as-inhibitors-of-nf-%C3%AE%C2%BAb-for-treatment-of-alzheimer-s-disease
#20
REVIEW
Ean-Jeong Seo, Nicolas Fischer, Thomas Efferth
Alzheimer's disease (AD) is the most prevalent form of dementia. The exact pathophysiology of this disease remains incompletely understood and safe and effective therapies are required. AD is highly correlated with neuroinflammation and oxidative stress in brain causing neuronal loss. Nuclear factor of activated B-cells (NF-κB) is involved in physiological inflammatory processes and thus representing a promising target for inflammation-based AD therapy. Phytochemicals are able to interfere with the NF-κB pathway...
March 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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