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Soil transmitted helminth

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https://www.readbyqxmd.com/read/29779225/soil-transmitted-helminth-infections-associated-with-wastewater-and-sludge-reuse-a-review-of-current-evidence
#1
REVIEW
Isaac Dennis Amoah, Anthony Ayodeji Adegoke, Thor Axel Stenström
OBJECTIVE: To review current evidence on infections related to the concentration of soil-transmitted helminth (STH) eggs in wastewater, sludge and vegetables irrigated with wastewater or grown on sludge-amended soils. METHOD: Search of Web of Science, Science Direct, PubMed and Google Scholar databases for publications reporting on STH egg concentration in wastewater, sludge and vegetables and for epidemiological studies on wastewater/sludge reuse and STH infections...
May 19, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29775454/in-vivo-and-in-vitro-studies-of-cry5b-and-nicotinic-acetylcholine-receptor-agonist-anthelmintics-reveal-a-powerful-and-unique-combination-therapy-against-intestinal-nematode-parasites
#2
Yan Hu, Melanie Miller, Bo Zhang, Thanh-Thanh Nguyen, Martin K Nielsen, Raffi V Aroian
BACKGROUND: The soil-transmitted nematodes (STNs) or helminths (hookworms, whipworms, large roundworms) infect the intestines of ~1.5 billion of the poorest peoples and are leading causes of morbidity worldwide. Only one class of anthelmintic or anti-nematode drugs, the benzimidazoles, is currently used in mass drug administrations, which is a dangerous situation. New anti-nematode drugs are urgently needed. Bacillus thuringiensis crystal protein Cry5B is a powerful, promising new candidate...
May 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29774289/high-prevalence-of-intestinal-worms-in-children-up-to-5-years-of-age-in-huaphan-province-lao-people-s-democratic-republic-pdr
#3
Naphavanh Nanthavong, Antony P Black, Phonepadith Khattignavong, Lavy Lorphachan, Keooudomphone Vilivong, Sylvie Goossens, Yves Buisson, Fabrice Quet, Claude P Muller, Satoshi Nakamura
Background: The prevalence of soil-transmitted helminth infection is high in Lao People's Democratic Republic (PDR), reaching 62% among school-children. However, this prevalence presents wide regional variations, due to differences in healthcare access and environmental factors. Curiously, there are few studies on helminth infections in pre-school children - an age group targeted by the national de-worming campaign. Therefore, a preliminary study was conducted in a remote region of Huaphan Province, North Laos, to determine the prevalence of helminth infections in pre-school children...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29772478/bacillus-thuringiensis-cry5b-protein-as-a-new-pan-hookworm-cure
#4
Yan Hu, Thanh-Thanh Nguyen, Alice C Y Lee, Joseph F Urban, Melanie M Miller, Bin Zhan, David J Koch, Jason B Noon, Ambily Abraham, Ricardo Toshio Fujiwara, Dwight D Bowman, Gary R Ostroff, Raffi V Aroian
Hookworms are intestinal nematode parasites that infect nearly half a billion people and are globally one of the most important contributors to iron-deficiency anemia. These parasites have significant impacts in developing children, pregnant women and working adults. Of all the soil-transmitted helminths or nematodes (STNs), hookworms are by far the most important, with disease burdens conservatively estimated at four million DALYs (Disability-Adjusted Life Years) and with productivity losses of up to US$139 billion annually...
May 4, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29753341/human-parasitology-and-parasitic-diseases-heading-towards-2050
#5
Peter J Hotez
By 2050 our civilized planet may be comprised predominantly of networked megacities embedded in warm subtropical and tropical climates, and under stress from climate change and catastrophic weather events. Urban slum areas in these cities, including those found in wealthier middle- and high-income nations (blue marble health), will be especially vulnerable to disease. Moreover, regional conflicts fought over shifting and limited resources, including water, will collapse health systems infrastructures to further promote disease emergence and reemergence...
2018: Advances in Parasitology
https://www.readbyqxmd.com/read/29753337/100-years-of-mass-deworming-programmes-a-policy-perspective-from-the-world-bank-s-disease-control-priorities-analyses
#6
Donald A P Bundy, Laura J Appleby, Mark Bradley, Kevin Croke, T Deirdre Hollingsworth, Rachel Pullan, Hugo C Turner, Nilanthi de Silva
For more than 100 years, countries have used mass drug administration as a public health response to soil-transmitted helminth infection. The series of analyses published as Disease Control Priorities is the World Bank's vehicle for exploring the cost-effectiveness and value for money of public health interventions. The first edition was published in 1993 as a technical supplement to the World Bank's World Development Report Investing in Health where deworming was used as an illustrative example of value for money in treating diseases with relatively low morbidity but high prevalence...
2018: Advances in Parasitology
https://www.readbyqxmd.com/read/29727708/artemisinin-and-its-derivatives-in-treating-helminthic-infections-beyond-schistosomiasis
#7
REVIEW
Nelson Siukei Lam, Xinxin Long, Xin-Zhuan Su, Fangli Lu
The World Health Organization estimated that more than 1.5 billion people are infected with soil-transmitted helminths globally, and foodborne trematodiases in humans cause ∼2 million life-years lost to disability and death worldwide every year. Investment in prevention, treatment, and awareness of helminth infections and discovery of new, safe, effective, and affordable anti-helminth drugs are urgently needed. Artemisinin (ART) and its derivatives have been widely used to treat malaria and other protozoan infections; they also possess activities against helminths...
May 1, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29726969/prevalence-of-strongyloides-stercoralis-infection-and-other-soil-transmitted-helminths-by-cross-sectional-survey-in-a-rural-community-in-gisagara-district-southern-province-rwanda
#8
Aloys Tuyizere, Alphonse Ndayambaje, Timothy D Walker, Claude Bayingana, Cyprien Ntirenganya, Vincent Dusabejambo, DeVon C Hale
Background: Strongyloides stercoralis is one of the most neglected tropical diseases. Sparse, dated central African and Rwandan data on seroprevalence are available to guide public health efforts and clinical care. Methods: In February 2016 we conducted a community-based cross-sectional study among 539 asymptomatic participants in a rural area in the Gisagara District, Southern Province, Rwanda. Direct faecal smear (DFS) and modified Koga agar plate culture (APC) were used to detect S...
May 2, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29723193/-s-wash-d-for-worms-a-pilot-study-investigating-the-differential-impact-of-school-versus-community-based-integrated-control-programs-for-soil-transmitted-helminths
#9
Naomi E Clarke, Archie C A Clements, Salvador Amaral, Alice Richardson, James S McCarthy, John McGown, Stuart Bryan, Darren J Gray, Susana V Nery
BACKGROUND: Soil-transmitted helminths (STH) infect nearly 1.5 billion individuals globally, and contribute to poor physical and cognitive development in children. STH control programs typically consist of regular delivery of anthelminthic drugs, targeting school-aged children. Expanding STH control programs community-wide may improve STH control among school-aged children, and combining deworming with improvements to water, sanitation and hygiene (WASH) may further reduce transmission...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29705768/soil-transmitted-helminth-infections-and-nutritional-status-in-ecuador-findings-from-a-national-survey-and-implications-for-control-strategies
#10
Ana L Moncayo, Raquel Lovato, Philip J Cooper
OBJECTIVE: The estimation of prevalence and intensity of soil-transmitted helminth (STH) infections at a country-level is an essential prerequisite for the implementation of a rational control programme. The aim of this present study was to estimate the prevalence and distribution of STH infections and malnutrition in school-age children in rural areas of Ecuador. DESIGN: Cross-sectional study from October 2011 to May 2012. SETTING: Eighteen rural schools were randomly selected from the three ecological regions of Ecuador (coastal, highlands and Amazon basin)...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29702653/efficacy-and-safety-of-co-administered-ivermectin-plus-albendazole-for-treating-soil-transmitted-helminths-a-systematic-review-meta-analysis-and-individual-patient-data-analysis
#11
Marta S Palmeirim, Eveline Hürlimann, Stefanie Knopp, Benjamin Speich, Vicente Belizario, Serene A Joseph, Michel Vaillant, Piero Olliaro, Jennifer Keiser
BACKGROUND: The soil-transmitted helminths (STH), Ascaris lumbricoides, Trichuris trichiura and hookworms infect 1.5 billion people worldwide and cause an estimated burden of 3.3 million disability-adjusted life years (DALYs). Current control strategies focus on morbidity reduction through preventive chemotherapy (PC) but the most commonly used recommended drugs (albendazole and mebendazole) are particularly inefficacious against T. trichiura. This, together with the threat of emerging drug resistance, calls for new control strategies, including co-administration with other anthelminthics...
April 27, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29698508/viewpoint-on-the-review-by-savioli-and-colleagues-on-the-2017-who-guideline-on-soil-transmitted-helminth-infections-in-at-risk-population-groups
#12
Antonio Montresor, Juan Pablo Peña-Rosas, Pura Rayco-Solon, Francesco Branca, Susan L Norris, Gautam Biswas
No abstract text is available yet for this article.
April 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29698486/review-of-the-2017-who-guideline-preventive-chemotherapy-to-control-soil-transmitted-helminth-infections-in-at-risk-population-groups-an-opportunity-lost-in-translation
#13
Lorenzo Savioli, Marco Albonico, Denis Daumerie, Nathan C Lo, J Russell Stothard, Samuel Asaolu, Louis Albert Tchuem Tchuenté, Roy M Anderson
No abstract text is available yet for this article.
April 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29673736/soil-transmitted-helminth-treatment-multiple-drug-regimens
#14
Simon J Brooker
No abstract text is available yet for this article.
April 16, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29673735/efficacy-and-tolerability-of-triple-drug-therapy-with-albendazole-pyrantel-pamoate-and-oxantel-pamoate-compared-with-albendazole-plus-oxantel-pamoate-pyrantel-pamoate-plus-oxantel-pamoate-and-mebendazole-plus-pyrantel-pamoate-and-oxantel-pamoate-against-hookworm
#15
Wendelin Moser, Somphou Sayasone, Syda Xayavong, Bangon Bounheuang, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser
BACKGROUND: Albendazole and mebendazole are commonly used to control hookworm, but have shortcomings in their efficacy profiles. We assessed whether triple drug therapy (TDT) with albendazole, pyrantel pamoate, and oxantel pamoate was more effective than the co-administration of two drugs for the treatment of hookworm infections. METHODS: A randomised, single-blind trial was done from Sept 27 until Nov 17, 2017, in Laos. Children (6-15 years) from six schools were invited to participate...
April 16, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29626554/physical-activity-and-dual-disease-burden-among-south-african-primary-schoolchildren-from-disadvantaged-neighbourhoods
#16
Markus Gerber, Ivan Müller, Cheryl Walter, Rosa du Randt, Larissa Adams, Stefanie Gall, Nandi Joubert, Siphesihle Nqweniso, Danielle Smith, Peter Steinmann, Nicole Probst-Hensch, Jürg Utzinger, Uwe Pühse
People from low- and middle-income countries still face challenges stemming from parasitic infections. Additionally, non-communicable diseases (NCDs) and their risk factors are rapidly increasing, which puts South African children at an elevated risk of a dual disease burden, with negative consequences for child development and wellbeing. Contrastingly, regular physical activity (PA) is associated with decreased cardiovascular disease (CVD) risk. Therefore, the objective of this study was to examine whether PA is associated with the double infection-CVD phenotype burden in South African schoolchildren...
April 4, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29622908/soil-contamination-rate-prevalence-intensity-of-infection-of-geohelminths-and-associated-risk-factors-among-residents-in-bazou-west-cameroon
#17
Blandine Ngatou Tchakounté, Vanessa Rosine Nkouayep, Josué Wabo Poné
Background: Soil-transmitted helminths (STH) infections remain an important public health problem in the tropics. This study aimed to evaluate the soil contamination rate and prevalence of infestations of geohelminth among residents in Bazou. Methods: Four hundred (400) soil samples and 182 stool specimens were collected respectively from four sites and from inhabitants aged 1 to 40 years and above in 12 households. A questionnaire was administered to evaluate risk factors of STH-infections...
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29621166/subclinical-enteric-parasitic-infections-and-growth-faltering-in-infants-in-s%C3%A3-o-tom%C3%A3-africa-a-birth-cohort-study
#18
Marisol Garzón, Luís Pereira-da-Silva, Jorge Seixas, Ana Luísa Papoila, Marta Alves
The associations between enteric pathogenic parasites and growth in infants in São Tomé were explored using a refined anthropometric approach to recognize early growth faltering. A birth cohort study was conducted with follow-up to 24 months of age. Microscopic examination for protozoa and soil-transmitted helminths was performed. Anthropometric assessments included: z-scores for weight-for-length (WLZ), length-for-age (LAZ), weight (WAVZ) and length velocities (LAVZ), length-for-age difference (LAD), and wasting and stunting risk (≤-1 SD)...
April 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29617737/efficacy-and-safety-of-ivermectin-against-trichuris-trichiura-in-preschool-and-school-aged-children-a-randomized-controlled-dose-finding-trial
#19
David Wimmersberger, Jean T Coulibaly, Jessica Schulz, Maxim Puchkow, Jörg Huwyler, Yves N'Gbesso, Jan Hattendorf, Jennifer Keiser
Background: Although trichuriasis affects millions of children worldwide, recommended drugs lack efficacy and new treatment options are urgently needed. Ivermectin has promising potential to complement the anthelminthic armamentarium. Methods: A randomized placebo-controlled trial was conducted in rural Côte d'Ivoire to provide evidence on the efficacy and safety of ascending oral ivermectin dosages in preschool-aged children and in schoolchildren infected with Trichuris trichiura...
March 30, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29611504/albendazole-treatment-improves-work-capacity-in-women-smallholder-farmers-infected-with-hookworm-a-double-blind-randomized-control-trial
#20
Margaret Salmon, Christian Salmon, Maurice Masoda, Jean-Maurice Salumu, Carmine Bozzi, Phil Nieburg, Lisa M Harrison, Debbie Humphries, Naomi Abaca Uvon, Sarah K Wendel, Clint Trout, Michael Cappello
An estimated 4.7 billion people live in regions exposed to soil-transmitted helminths, intestinal parasites that have significant impacts on the health of women smallholder farmers. The goal of this trial was to determine whether treatment with albendazole impacts the work capacity of these farmers. This is a prospective double-blind, randomized effectiveness trial. Participants ( N = 250) were randomly selected from safe motherhood groups in the Democratic Republic of Congo. Prevalence/intensity of hookworm infection, hemoglobin, and demographics was obtained...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
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