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papillary renal cell carcinoma

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https://www.readbyqxmd.com/read/28923625/genitourinary-malignancies-in-transplant-or-dialysis-patients-the-frequency-of-two-newly-described-2016-world-health-organization-histopathologic-types
#1
A Billis, L L L Freitas, L B E Costa, I S Barreto, M A Asato, K S Araujo, D M Losada, A P Herculiani, G V B S Tabosa, B C Zaidan, G L P Oliveira, L Q A Bastos, R M Rocha
BACKGROUND: The aim of this study was to revise the histopathologic types of neoplasias in the genitourinary tract and determine the frequency of 2 new entities included in the 2016 book of World Health Organization classification of renal tumors. It is not established so far whether these 2 recently described tumors are the most frequent in association with end-stage kidney disease. METHODS: In a retrospective analysis, we revised the histopathologic type of 37 genitourinary tumors from 21 patients in dialysis and/or submitted to renal transplantation from 2003 to 2016 aiming to find the frequency of acquired cystic disease-associated renal cell carcinoma and clear cell papillary (tubulopapillary) renal cell carcinoma...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28913849/ethnic-disparities-in-renal-cell-carcinoma-an-analysis-of-hispanic-patients-in-a-single-payer-healthcare-system
#2
Alfredo Suarez-Sarmiento, Xiaopan Yao, Jonathan N Hofmann, Jamil S Syed, Wei K Zhao, Mark P Purdue, Wong-Ho Chow, Douglas Corley, Brian Shuch
OBJECTIVE: To investigate differences between Hispanics and non-Hispanic whites diagnosed with and treated for renal cell carcinoma in an equal access healthcare system. METHODS: We carried out a retrospective cohort study within the Kaiser Permanente healthcare system using records from renal cell carcinoma cases. Ethnicity was identified as Hispanic or non-Hispanic whites. Patient characteristics, comorbidities, tumor characteristics and treatment were compared...
September 15, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28912913/paraneoplastic-dermatomyositis-syndrome-presenting-as-dysphagia
#3
Emmanuel Ofori, Daryl Ramai, Mel Ona, Madhavi Reddy
Dermatomyositis (DM) is a rare autoimmune condition which predominantly affects females in the fifth and sixth decades of life. DM presents acutely or progressively as painless proximal skeletal muscle weakness and can be associated with a heliotropic rash around the eyes, and Gottron's papules on extensor surfaces of the hands. While the pathophysiology of DM is still unclear, abnormal T- and B-cell immune activity has been reported. DM has been associated with malignancy and has been shown to appear before, concurrently with, or after diagnosis of cancer...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28898190/renal-tumors-of-childhood-radiologic-pathologic-correlation-part-2-the-2nd-decade-from-the-radiologic-pathology-archives
#4
Ellen M Chung, Grant E Lattin, Kimberly E Fagen, Andrew M Kim, Michael A Pavio, Adam J Fehringer, Richard M Conran
Malignant renal tumors account for 7% of childhood cancers, and Wilms tumors are by far the most common-but not in older children and adolescents. Among individuals in the latter half of their 2nd decade of life, renal cell carcinoma (RCC) is more common than Wilms tumor. The histopathologic spectrum of RCCs in children differs from that in adults. The most common subtype of RCC in children and adolescents is Xp11.2 translocation RCC, which is distinguished by hyperattenuation at nonenhanced computed tomography, a defined capsule, and associated retroperitoneal lymphadenopathy...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28894579/metanephric-adenoma-treated-with-laparoscopic-nephrectomy-a-case-report
#5
Yuta Takezawa, Kouji Izumi, Hiroko Ikeda, Taito Nakano, Hiroyuki Konaka, Atsushi Mizokami, Mikio Namiki
Metanephric adenoma is an uncommon benign renal tumor that occurs predominantly in adult females and rarely in children. Its histomorphology resembles that of epithelial Wilms' tumor and papillary renal cell carcinoma. From a diagnostic and therapeutic perspective, recognition of this entity is important as it has a more favorable clinical outcome compared with Wilms' tumor and renal cell carcinoma. Metanephric adenoma should not be treated with nephrectomy if the tumor size is small. However, preoperative diagnosis of this disease is extremely challenging...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28893213/application-and-analysis-of-retroperitoneal-laparoscopic-partial-nephrectomy-with-sequential-segmental-renal-artery-clamping-for-patients-with-multiple-renal-tumor-initial-experience
#6
Jundong Zhu, Fan Jiang, Pu Li, Pengfei Shao, Chao Liang, Aiming Xu, Chenkui Miao, Chao Qin, Zengjun Wang, Changjun Yin
BACKGROUND: To explore the feasibility and safety of retroperitoneal laparoscopic partial nephrectomy with sequential segmental renal artery clamping for the patients with multiple renal tumor of who have solitary kidney or contralateral kidney insufficiency. METHODS: Nine patients who have undergone retroperitoneal laparoscopic partial nephrectomy with sequential segmental renal artery clamping between October 2010 and January 2017 were retrospectively analyzed...
September 11, 2017: BMC Urology
https://www.readbyqxmd.com/read/28877071/uncommon-localization-of-extrarenal-xp11-2-translocation-associated-renal-cell-carcinoma-rcc-case-report
#7
Jaudah Ahmed Al-Maghrabi, Mohamad Nidal Khabaz
The World Health Organization has recognized Xp11.2 translocation-associated renal cell carcinoma (RCC) as a distinct neoplasm that arises within the kidney. Although many reports of extrarenal carcinoma may be found in the literature, to the best of our knowledge, Xp11 translocation-associated RCC with intact kidneys has not been documented. This report describes a multilobulated right retroperitoneal soft tissue mass (7.9×5.3×12.6 cm) of a 37-year-old man complaining of abdominal pain in the right side...
September 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28877054/melanotic-translocation-renal-cell-carcinoma-with-a-novel-arid1b-tfe3-gene-fusion
#8
Tatjana Antic, Jerome B Taxy, Mir Alikhan, Jeremy Segal
A 36-year-old male was found to have a 7.0 cm left upper pole renal mass on renal ultrasound. Following nephrectomy, the mass was grossly ill-demarcated, friable and red-brown, invading renal parenchyma, hilar fat and the renal vein. Microscopically, the tumor had a nested and papillary architecture. The cells demonstrated abundant clear and eosinophilic cytoplasm and focal intracytoplasmic melanin pigment. Nucleoli were prominent. By immunohistochemistry, the tumor was positive for TFE3; HMB-45 stained approximately 5% of tumor cells corresponding to the histologic melanin pigment, which was confirmed with Fontana-Masson stain with bleach...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28861890/high-grade-renal-cell-carcinoma-with-emperipolesis-clinicopathological-immunohistochemical-and-molecular-genetic-analysis-of-14-cases
#9
Pavla Rotterova, Petr Martinek, Reza Alaghehbandan, Kristyna Prochazkova, Ivan Damjanov, Joanna Rogala, Saul Suster, Delia Perez-Montiel, Isabel Alvarado-Cabrero, Maris Sperga, Marian Svajdler, Kvetoslava Michalova, Kristyna Pivovarcikova, Ondrej Daum, Milan Hora, Martin Dusek, Ondrej Ondic, Adela Stehlikova, Michal Michal, Ondrej Hes
Emperipolesis has recently been described as a constant feature of "biphasic squamoid" papillary renal cell carcinoma (BPRCC). We also noticed this in some high-grade (HG) RCC, which promoted the present study to estimate the incidence of emperipolesis in RCCs and to describe them in further detail. 14 cases of HGRCC showing emperipolesis were retrieved from our registry. Microscopic examination of filed slides was supplemented with immunohistochemical and molecular-genetic analyses using paraffin embedded tissue...
September 1, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28860812/an-integrated-analysis-for-long-noncoding-rnas-and-micrornas-with-the-mediated-competing-endogenous-rna-network-in-papillary-renal-cell-carcinoma
#10
Chuiguo Huang, Naijun Yuan, Liying Wu, Xiaofu Wang, Junqiang Dai, Pan Song, Fengxi Li, Changbao Xu, Xinghua Zhao
Papillary renal cell carcinoma (PRCC) is the second most common subtype of renal cell carcinoma, and it lacks effective therapeutic targets and prognostic molecular biomarkers. Attention has been increasingly focused on long noncoding RNAs (lncRNAs), which can act as competing endogenous RNA (ceRNA) to compete for shared microRNAs (miRNAs) in the tumorigenesis of human tumors. Therefore, to clarify the functional roles of lncRNAs with respect to the mediated ceRNA network in PRCC, we comprehensively integrated expression profiles, including data on mRNAs, lncRNAs and miRNAs obtained from 289 PRCC tissues and 32 normal tissues in The Cancer Genome Atlas...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28858743/quadruple-primary-urogenital-cancers-a-case-report
#11
Florin-Ioan Elec, Andreea Zaharie, Bogdan-Mihai Ene, Liviu Ghervan
INTRODUCTION: Urogenital cancers are not an uncommon occurrence in daily practice. Prostate cancer is the second most frequent cancer in men, kidney cancer accounts for 2.4% of all cancers and bladder cancers represent 3.1% of cancers in both men and women [1]. However, the cases of a simultaneous development of all three cancers, including one with a neuroendocrine component, are very few and far between. PRESENTATION OF CASE: Our case report involves a case of a patient with prostate adenocarcinoma, clear-cell renal carcinoma, papillary renal carcinoma and small-cell bladder cancer...
August 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28843710/renal-collision-tumor-composed-of-oncocytoma-and-mucinous-tubular-and-spindle-cell-carcinoma-case-report-of-an-unprecedented-entity
#12
Komal Arora, Ross Miller, Seema Mullick, Steven Shen, Alberto G Ayala, Jae Y Ro
Primary renal collision tumors composed of two histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial cells. Mucinous tubular and spindle cell carcinoma (MTSCC) of kidney is a rare, relatively recently described renal neoplasm that was first included in the 2004 World Health Organization RCC classification as a distinct entity. Current studies suggest the tumor originates from the proximal nephron, although it is still controversial...
August 23, 2017: Human Pathology
https://www.readbyqxmd.com/read/28840857/detection-of-6-tfeb-amplified-renal-cell-carcinomas-and-25-renal-cell-carcinomas-with-mitf-translocations-systematic-morphologic-analysis-of-85-cases-evaluated-by-clinical-tfe3-and-tfeb-fish-assays
#13
Stephanie L Skala, Hong Xiao, Aaron M Udager, Saravana M Dhanasekaran, Sudhanshu Shukla, Yang Zhang, Carrie Landau, Lina Shao, Diane Roulston, Lisha Wang, Javed Siddiqui, Xuhong Cao, Cristina Magi-Galluzzi, Miao Zhang, Adeboye O Osunkoya, Steven C Smith, Jesse K McKenney, Bryan L Betz, Jeffrey L Myers, Arul M Chinnaiyan, Scott A Tomlins, Rohit Mehra
Renal cell carcinomas with MITF aberrations demonstrate a wide morphologic spectrum, highlighting the need to consider these entities within the differential diagnosis of renal tumors encountered in clinical practice. Herein, we describe our experience with application of clinical fluorescence in situ hybridization (FISH) assays for detection of TFE3 and TFEB gene aberrations from 85 consecutive renal cell carcinoma cases submitted to our genitourinary FISH service. Results from 170 FISH assays performed on these tumors were correlated with available clinicopathologic findings...
August 25, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28836063/prognostic-significance-of-fuhrman-grade-and-age-for-cancer-specific-and-overall-survival-in-patients-with-papillary-renal-cell-carcinoma-results-of-an-international-multi-institutional-study-on-2189-patients
#14
H Borgmann, M Musquera, A Haferkamp, A Vilaseca, T Klatte, S F Shariat, A Scavuzzo, M A Jimenez Rios, I Wolff, U Capitanio, P Dell'Oglio, L M Krabbe, E Herrmann, T Ecke, D Vergho, N Huck, N Wagener, S Pahernik, S Zastrow, M Wirth, C Surcel, C Mirvald, K Prochazkova, G Hutterer, R Zigeuner, L Cindolo, M Hora, C G Stief, M May, S D Brookman-May
PURPOSE: Because the prognostic impact of the clinical and pathological features on cancer-specific survival (CSS) and overall survival (OS) in patients with papillary renal cell carcinoma (papRCC) is still controversial, we want to assess the impact of clinicopathological features, including Fuhrman grade and age, on survival in surgically treated papRCC patients in a large multi-institutional series. METHODS: We established a comprehensive multi-institutional database of surgically treated papRCC patients...
August 23, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28833389/morphologic-spectrum-of-renal-cell-carcinoma-unclassified-an-analysis-of-136-cases
#15
Carmen M Perrino, David J Grignon, Sean R Williamson, Muhammad T Idrees, John N Eble, Liang Cheng
AIMS: Renal cell carcinoma, unclassified (RCCU) is a category that includes a morphologically and biologically heterogeneous group of tumors that are unable to be diagnosed as other well-defined entities. We aim to describe the morphologic findings of tumors within this category and to determine the most frequent morphologic features leading to classification difficulty. METHODS AND RESULTS: One hundred and thirty-six cases of RCCU were examined. Patients ranged in age from 23 to 87 years...
August 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28832083/a-unique-immunofluorescence-protocol-to-detect-protein-expression-in-vascular-tissues-tacking-a-long-standing-pathological-hitch
#16
Puneet Gandhi, Richa Khare
OBJECTIVE: Autofluorescence induced interference is one of the major drawbacks in immunofluorescence analysis of formalin-fixed paraffin-embedded tissues, as it decreases the signal-to-noise ratio of specific labeling. Apart from aldehyde-fixation induced artifacts; collagen and elastin, red blood cells and endogenous fluorescent pigment lipofuscin are prime sources of autofluorescence in vascular and aging tissues. We describe herein, an optimized indirect-immunofluorescence method for archival formalin-fixed paraffin-embedded tissues tissues and cryo sections, using a combination of 3-reagents in a specific order, to achieve optimal fluorescence signals and imaging...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28828638/fat-poor-angiomyolipoma-differentiation-from-renal-cell-carcinoma-at-320-slice-dynamic-volume-ct-perfusion
#17
Chao Chen, Qinqin Kang, Bing Xu, Zhang Shi, Hairuo Guo, Qiang Wei, Yayun Lu, Xinhuai Wu
PURPOSE: To compare various CT perfusion features of fat poor angiomyolipoma (AML) with those of size-matched renal cell carcinoma (RCC). METHODS: One hundred and seventy-four patients [16 with fat poor AML (mean diameter, 3.1 cm; range, 1.5-5.5 cm) and 158 with RCC (mean diameter, 3.2 cm; range, 2.4-5.4 cm)] who had undergone 320-slice dynamic volume CT perfusion were evaluated. Equivalent blood volume (BV Equiv), permeability surface-area product (PS), and blood flow (BF) of tumor were measured and analyzed...
August 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28827104/comprehensive-evaluation-of-prostate-specific-membrane-antigen-expression-in-the-vasculature-of-renal-tumors-implications-for-imaging-studies-and-prognostic-role
#18
Sophia Spatz, Yuri Tolkach, Klaus Jung, Carsten Stephan, Jonas Busch, Bernhard Ralla, Anja Rabien, Georg Feldmann, Peter Brossart, Ralph A Bundschuh, Hojjat Ahmadzadehfar, Markus Essler, Marieta Toma, Stefan C Müller, Jörg Ellinger, Stefan Hauser, Glen Kristiansen
PURPOSE: Prostate-specific membrane antigen (PSMA) is expressed by endothelium of many tumors. The aim of the study was to find a rationale for PSMA-based imaging and to investigate the prognostic role of vascular PSMA expression in patients with renal cell carcinoma (RCC). MATERIALS AND METHODS: Two-hundred fifty seven patients with RCC were included with a median follow-up exceeding 10.0 years. PSMA expression on the tumor vessels was detected by immunohistochemistry...
August 18, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28816276/-percutaneous-biopsy-of-the-renal-masses-under-ultrasound-a-single-center-14-years-experience
#19
Y X Zhang, X B Meng, L Yao, C J Zhang, G Song, L Cai, Z Zhang, X S Li, K Gong, S Q Li, G Z Shan, Q He, X Y Yang, Z S He, L Q Zhou
OBJECTIVE: To assess the diagnostic rate, safety and clinical application of percutaneous renal masses biopsy for advanced renal cell carcinoma patients. METHODS: In this retrospective study, we collected the data of renal masses from the patients who underwent renal masses biopsy under ultrasound from April 2001 to December 2014 in Peking University First Hospital. A total of 75 patients who were undiagnosed or diagnosed with advanced renal cell carcinoma by the imageological method were enrolled in this study...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28816272/-radical-nephrectomy-and-thrombectomy-for-mayo-clinic-stage-iii-tumor-thrombus-a-surgical-technique-and-clinical-experience
#20
Z Liu, L L Ma, X J Tian, G L Wang, X F Hou, S D Zhang, S H Deng
OBJECTIVE: To evaluate the effectiveness and safety of radical nephrectomy and inferior vena cava thrombectomy in the treatment of patients with Mayo III tumor thrombus, and to introduce our experience and surgical technique. METHODS: The clinical data of 8 patients with Mayo III tumor thrombus from October 2014 to September 2016 were analyzed retrospectively. Of the 8 patients, 3 were male and 5 were female. The average age was (50.8±18.7) years (18 to 77 years)...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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