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https://www.readbyqxmd.com/read/28724523/savolitinib-heads-for-phase-iii-trial-in-prcc
#1
(no author information available yet)
A phase II trial of savolitinib, a MET inhibitor, found that the drug induced partial responses in some patients with papillary renal cell carcinoma and was well tolerated, prompting drug makers Chi-Med and AstraZeneca to launch a phase III study.
July 19, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28721478/differentiation-of-renal-cell-carcinoma-subtypes-with-different-iodine-quantification-methods-using-single-phase-contrast-enhanced-dual-energy-ct-areal-vs-volumetric-analyses
#2
Chenchen Dai, Yingli Cao, Yan Jia, Yuqin Ding, Ruofan Sheng, Mengsu Zeng, Jianjun Zhou
PURPOSE: To investigate the possibility of iodine quantification during a single nephrographic phase in characterizing renal cell carcinoma (RCC) subtypes and if there is a difference between areal and volumetric iodine quantification methods. MATERIALS AND METHODS: This retrospective study included 110 patients with 113 histopathologically confirmed RCCs scanned by dual-energy CT at the nephrographic phase before surgeries. For each lesion, an areal measurement of the iodine concentration with maximum enhancement (I max enhan) and the iodine concentration with maximum area among slices (I max area), as well as a volumetric iodine concentration of the whole-tumor (I volume), were evaluated by two independent radiologists...
July 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28718911/clear-cell-renal-cell-carcinoma-validation-of-who-isup-grading
#3
Julien Dagher, Brett Delahunt, Nathalie Rioux-Leclercq, Lars Egevad, John R Srigley, Geoffrey Coughlin, Nigel Dunglinson, Troy Gianduzzo, Boon Kua, Greg Malone, Ben Martin, John Preston, Morgan Pokorny, Simon Wood, John Yaxley, Hemamali Samaratunga
AIM: In 2012, the International Society of Urological Pathology (ISUP) introduced a novel grading system for clear cell and papillary renal cell carcinoma (RCC) based upon increasing nucleolar prominence in grades 1 to 3, with the presence of extreme nuclear pleomorphism and/or tumour giant cells and/or sarcomatoid and/or rhabdoid differentiation as criteria for grade 4. This system is now incorporated in the latest World Health Organization renal tumour classification, being designated WHO/ISUP grading...
July 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28710314/sarcomatoid-renal-cell-carcinoma-has-a-distinct-molecular-pathogenesis-driver-mutation-profile-and-transcriptional-landscape
#4
Zixing Wang, Tae Beom Kim, Bo Peng, Jose A Karam, Chad J Creighton, Aron Y Joon, Fumi Kawakami, Patricia Trevisan, Eric Jonasch, Chi-Wan Chow, Jaime Rodriguez-Canales, Pheroze Tamboli, Nizar M Tannir, Christopher G Wood, Federico A Monzon, Keith A Baggerly, Marileila Varella-Garcia, Bogdan Czerniak, Ignacio I Wistuba, Gordon B Mills, Kenna Shaw, Ken Chen, Kanishka Sircar
Sarcomatoid renal cell carcinoma (SRCC) ranks among the most aggressive clinicopathologic phenotypes of RCC. However, the paucity of high-quality, genome-wide molecular examinations of SRCC has hindered our understanding of this entity.<br /><br />Experimental Design: We interrogated the mutational, copy number, and transcriptional characteristics of SRCC and compared these data with those of non-sarcomatoid RCC (RCC). We evaluated whole exome sequencing, single nucleotide polymorphism, and RNA sequencing data from patients with SRCC (n=65) and RCC (n=598) across different parent RCC subtypes, including clear cell RCC, papillary RCC, and chromophobe RCC subtypes...
July 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28705707/gata3-as-a-valuable-marker-to-distinguish-clear-cell-papillary-renal-cell-carcinomas-from-morphologic-mimics
#5
Jose G Mantilla, Tatjana Antic, Maria Tretiakova
Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade, indolent neoplasm, with no reported cases of death from disease or metastasis. These lesions can show clinical, morphologic and immunophenotypic overlap with several aggressive forms of renal cell carcinoma (RCC), including clear cell (CCRCC), translocation RCC and papillary RCC (PRCC) with cytoplasmic clearing. Given the difference in behavior, it is important to reliably separate these entities. We retrospectively reviewed 47 tumors from 45 patients with morphologic features of CCPRCC...
July 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28700432/novel-fumarate-hydratase-mutation-in-siblings-with-early-onset-uterine-leiomyomas-and-hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome
#6
Vinay Gunnala, Nigel Pereira, Mohamad Irani, Debra Lilienthal, Edyta C Pirog, Robert Soslow, Thomas A Caputo, Rony Elias, Isaac Kligman, Zev Rosenwaks
Hereditary leiomyomatosis renal cell cancer syndrome is an autosomal dominant disorder characterized by uterine and cutaneous leiomyomas and increased predisposition to renal cell carcinoma, papillary type II. The syndrome is caused by heterozygous mutations to the fumarate hydratase (FH) gene located on chromosome 1. Affected females generally present with early onset, atypical uterine leiomyomas and cutaneous findings, however, delays in diagnosis are very common in patients with isolated uterine findings...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28697675/malignant-mixed-epithelial-and-stromal-tumor-of-the-kidney-with-2-simultaneous-renal-carcinomas-in-a-male-patient-case-report-and-review-of-the-literature
#7
Aileen Grace P Arriola, Benjamin L Taylor, Sophia Ma, S Bruce Malkowicz, Priti Lal
The majority of mixed epithelial and stromal tumors (MEST) of the kidney are benign entities found in female patients. Malignant MEST of the kidney is an extremely rare entity that often behaves clinically similar to an undifferentiated sarcoma. We report a case of a malignant MEST with synchronous papillary and clear cell renal cell carcinomas (RCCs) in a 61-year-old Caucasian man who presented with an incidental finding of a left renal mass on workup for back pain. The patient underwent a left radical nephrectomy, with histopathology confirming a malignant MEST, intimately associated papillary RCC, and separate adjacent focus of clear cell RCC...
July 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28695322/the-tumor-entity-denominated-clear-cell-papillary-renal-cell-carcinoma-according-to-the-who-2016-new-classification-have-the-clinical-characters-of-a-renal-cell-adenoma-as-does-harbor-a-benign-outcome
#8
REVIEW
Francesco Massari, Chiara Ciccarese, Ondrej Hes, Michal Michal, Anna Caliò, Michelangelo Fiorentino, Francesca Giunchi, Alessandro D'Amuri, Francesca Sanguedolce, Roberto Sabbatini, Annalisa Guida, Andrea Ardizzoni, Camillo Porta, Roberto Iacovelli, Giampaolo Tortora, Luca Cima, Cinzia Ortega, Alberto Lapini, Guido Martignoni, Matteo Brunelli
The new WHO 2016 classification of renal neoplasia encounters the new entity called "clear cell papillary renal cell carcinoma" (ccpRCC). The ccpRCC has been long included as a subtype of clear cell RCC histotype and it actually ranges from 2 to 9% in different routinely available cohort of renal carcinomas. Of important note, ccpRCC does not show any recurrences or metastases or lymph-node invasion and the outcome is always good. We reviewed twenty-four publications with available follow-up for patients (no...
July 10, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28680002/chromophobe-renal-cell-carcinoma-like-thyroid-carcinoma-a-novel-clinicopathologic-entity-possibly-associated-with-tuberous-sclerosis-complex
#9
Mitsuyoshi Hirokawa, Akira Miyauchi, Minoru Kihara, Takumi Kudo, Yuko Hashimoto, Shinichi Suzuki, Tsutomu Daa, Huy Gia Vuong, Norisato Mitsutake
We report three cases of chromophobe renal cell carcinoma-like thyroid carcinoma as a novel clinicopathologic entity possibly associated with tuberous sclerosis complex. A 15-year-old female, a 19-year-old male, and a 21-year-old male presented with primary thyroid carcinoma. Two of the patients had associated tuberous sclerosis complex. Macroscopically, the carcinomas showed invasive growth. Histologically, the carcinoma cells showed a trabecular pattern with thin vascular stroma, and were characterized by abundant eosinophilic cytoplasm with perinuclear clearing, a prominent cell border, a wrinkled nuclear membrane, and binucleation, which are all features of chromophobe renal cell carcinoma...
July 6, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28678013/-major-complications-of-acquired-renal-cystic-disease-w%C3%A3-nderlich-syndrome-and-papilar-carcinoma
#10
Enrique Rodríguez-Zarco, Ana Vallejo-Benítez, Antonio Delgado Cotán, Sofía Pereira-Gallardo
OBJETIVE: We report a case of acquired renal cystic disease associated with renal dialysis and endstage renal disease. The patient suffered the two major complications related with acquired renal cystic disease; hemorrhage and renal carcinoma. METHODS: Our case is a patient with acquired renal cystic disease, single kidney after surgery for renal clear cell carcinoma four years earlier, who developed a Wünderlich syndrome (WS). RESULTS: The histological study of the nephrectomy specimen showed a renal papillary carcinoma in the context of acquired renal cystic disease after surgery for a WS...
July 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28669737/savolitinib-for-met-driven-papillary-renal-cell-carcinoma
#11
Judith A Gilbert
No abstract text is available yet for this article.
June 29, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28669641/prognostic-significance-of-extensive-necrosis-in-renal-cell-carcinoma
#12
Jennifer Collins, Jonathan I Epstein
Few studies using the current classification of renal cell carcinoma (RCC) have looked at a large number of cases with near total necrosis. We identified 21 cases of resections of RCC with >90% necrosis from the archives of Johns Hopkins Hospital between 2000-2015. Patients' mean age was 59yrs. (43-77) with 16 (76%) males. 12 (57%) cases were papillary RCC, 4 (19%) clear cell papillary RCC, 4 (19%) clear cell RCC, 1 (5%) unclassified with sarcomatoid differentiation. International Society of Urological Pathology (ISUP) nucleolar grade was grade 1 (9 cases) or grade 2 (9 cases)...
June 29, 2017: Human Pathology
https://www.readbyqxmd.com/read/28669254/papillary-renal-cell-carcinoma-with-osteosarcomatous-heterologous-differentiation-a-case-report-with-molecular-genetic-analysis-and-review-of-the-literature
#13
John James Aird, Aisling U Nic An Riogh, Stewart Fleming, R Gordon Hislop, Paul Sweeney, Nick Mayer
Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC). In rare cases, heterologous differentiation has been described. We present a case of heterologous osteosarcomatous differentiation in association with sarcomatoid papillary RCC including an analysis of chromosomal copy number alteration. This is the first case to identify heterologous differentiation in association with papillary RCC. The patient was a 70-year-old man who had a mass in the right kidney. Speckled calcification was seen on computed tomography scan...
June 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28669081/distribution-of-vascular-patterns-in-different-subtypes-of-renal-cell-carcinoma-a-morphometric-study-in-two-distinct-types-of-blood-vessels
#14
Amparo Ruiz-Saurí, V García-Bustos, E Granero, S Cuesta, M A Sales, V Marcos, A Llombart-Bosch
To analyze the presence of mature and immature vessels as a prognostic factor in patients with renal cell carcinoma and propose a classification of renal cancer tumor blood vessels according to morphometric parameters. Tissue samples were obtained from 121 renal cell carcinoma patients who underwent radical nephrectomy. Staining with CD31 and CD34 was used to differentiate between immature (CD31+) and mature (CD34+) blood vessels. We quantified the microvascular density, microvascular area and different morphometric parameters: maximum diameter, minimum diameter, major axis, minor axis, perimeter, radius ratio and roundness...
July 1, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28667776/preservation-of-truncal-genomic-alterations-in-clear-cell-and-papillary-renal-cell-carcinomas-with-sarcomatoid-features-an-intra-and-intertumoral-multifocal-fluorescence-in-situ-hybridization-analysis-reveals-limited-genetic-heterogeneity
#15
Joseph M Sanfrancesco, John N Eble, David J Grignon, Mingsheng Wang, Shaobo Zhang, Chandru P Sundaram, Muhammad T Idrees, Roberto Pili, Erik Kouba, Liang Cheng
Understanding tumor genomic heterogeneity may offer vital information in an age of targeted therapy for renal cell carcinoma. We sought to investigate hallmark truncal chromosomal alterations between conventional, sarcomatoid, and matched metastatic tumor foci in clear cell and papillary renal cell carcinomas. A retrospective review identified 58 cases including clear cell (CCRCC) and papillary renal cell carcinomas (PRCC). All cases contained sarcomatoid transformation. Additionally, 10 of 58 patients had matched metastatic disease available for analysis...
July 1, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28662997/next-generation-immunohistochemistry-emerging-substitutes-to-genetic-testing
#16
REVIEW
Juliana Andrici, Anthony J Gill, Jason L Hornick
The identification of at-risk kindreds facilitates screening and risk reduction strategies for patients with hereditary cancer predisposition syndromes. Recently, immunohistochemistry (IHC) has emerged as a cost-effective strategy for detecting or inferring the presence of mutations in both tumors and the germline of patients presenting with tumors associated with hereditary cancer predisposition syndromes. In this review we discuss the use of novel IHC markers, including PRKAR1A, β-catenin, SDHB, fumarate hydratase and 2SC, HRASQ61R, BAP1, parafibromin and glucagon, which have either established applications or show promise for surgical pathologists to complement morphological or clinical suspicion of hereditary cancer predisposition syndromes...
June 27, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28662726/identification-of-clear-cell-renal-cell-carcinoma-and-oncocytoma-using-a-three-gene-promoter-methylation-panel
#17
Ana Sílvia Pires-Luís, Pedro Costa-Pinheiro, Maria João Ferreira, Luís Antunes, Francisco Lobo, Jorge Oliveira, Rui Henrique, Carmen Jerónimo
BACKGROUND: Promoter methylation has emerged as a promising class of epigenetic biomarkers for diagnosis and prognosis of renal cell tumors (RCTs). Although differential gene promoter methylation patterns have been reported for the major subtypes (clear cell, papillary and chromophobe renal cell carcinoma, and oncocytoma), validation of diagnostic performance in independent series have been seldom performed. Herein, we aimed at assessing the diagnostic performance of genes previously shown to be hypermethylated in RCTs in different clinical settings...
June 29, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28659364/acute-cor-pulmonale-due-to-pulmonary-tumour-thrombotic-microangiopathy-from-renal-cell-carcinoma
#18
Maria Story, Sook Kyung Kwon, Robert Robinson, Spyridon Fortis
We report the case of a previously healthy man who presented with subacute dyspnoea after a long drive. He developed hypoxic respiratory failure, thought secondary to a massive pulmonary embolism and was treated with tissue plasminogen activator but died in the hospital despite aggressive medical measures. Autopsy revealed pulmonary tumour thrombotic microangiopathy (PTTM) from papillary renal cell carcinoma. PTTM is a rare clinicopathological syndrome that clinically results in symptoms of dyspnoea and right heart failure...
June 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28656700/chromosomal-abnormalities-of-high-grade-mucinous-tubular-and-spindle-cell-carcinoma-of-the-kidney
#19
Evita T Sadimin, Ying-Bei Chen, Lu Wang, Pedram Argani, Jonathan I Epstein
INTRODUCTION: Mucinous tubular and spindle cell carcinoma (MTSC) of the kidney is a distinct entity characterized by bland tightly packed elongated tubules and spindle cells with low nucleolar grade in a basophilic mucinous stroma. Several case studies have reported MTSC with high grade features and have brought into question whether they represented MTSC or a variant of papillary renal cell carcinoma. MATERIALS AND METHODS: We searched our pathology database and identified seven cases: six MTSC with high International Society of Urological Pathology (ISUP) nucleolar grade, and one MTSC with overall low nucleolar grade but extensive necrosis...
June 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28646318/primary-renal-paragangliomas-and-renal-neoplasia-associated-with-pheochromocytoma-paraganglioma-analysis-of-von-hippel-lindau-vhl-succinate-dehydrogenase-sdhx-and-transmembrane-protein-127-tmem127
#20
Sounak Gupta, Jun Zhang, Dragana Milosevic, John R Mills, Stefan K Grebe, Steven C Smith, Lori A Erickson
Alterations of von Hippel-Lindau (VHL), succinate dehydrogenase (SDHX), and TMEM127 have been associated with the development of pheochromocytomas (PCs) and paragangliomas (PGLs) and are also associated with the development of renal neoplasms. This study involved 2 primary renal PGL and 12 cases of PC/PGL with associated renal neoplasia with a mean follow up of 74 months. Germline VHL and SDHX mutation status was obtained from the medical record. Immunohistochemistry for SDHB and mutation analysis for TMEM127 was performed, in addition to analysis of The Cancer Genome Atlas datasets for SDHX and TMEM127 mutated renal cell carcinomas (RCCs)...
June 23, 2017: Endocrine Pathology
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