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papillary renal cell carcinoma

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https://www.readbyqxmd.com/read/29344091/the-correlation-between-gain-of-chromosome-8q-and-survival-in-patients-with-clear-and-papillary-renal-cell-carcinoma
#1
Reza Mehrazin, Essel Dulaimi, Robert G Uzzo, Karthik Devarjan, Jianming Pei, Marc C Smaldone, Alexander Kutikov, Joseph R Testa, Tahseen Al-Saleem
Background: The proto-oncogene c-MYC, located on chromosome 8q, can be upregulated through gain of 8q, causing alteration in biology of renal cell carcinoma (RCC). The aim of this study was to evaluate the prevalence of c-MYC through chromosome 8q gain and to correlate findings with cancer-specific mortality (CSM), and overall survival (OS). Methods: Cytogenetic analysis by conventional or Chromosomal Genomic Microarray Analysis (CMA) was performed on 414 renal tumors...
January 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29343919/papillary-renal-cell-carcinoma-with-abscess-formation-a-report-of-three-cases
#2
Girdhar Singh Bora, Pankaj Panwar, Ravimohan S Mavuduru, Nandita Kakkar
We report three cases of renal cell carcinoma (RCC) associated with abscess formation. Such association has been reported uncommonly in literature. Our cases were unique in that final histopathological report was papillary RCC in all of the patients.
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29340018/survival-prediction-of-kidney-renal-papillary-cell-carcinoma-by-comprehensive-lncrna-characterization
#3
Huihua Lan, Jianghui Zeng, Gang Chen, Huayi Huang
Kidney renal papillary cell carcinoma (KIRP) accounts for 10%-15% of renal cell carcinoma (RCC), patients with KIRP tend to have a poor prognosis, and there was a lack of effective prognostic indicators for this type of cancer. Currently, owing to the availability of The Cancer Genome Atlas (TCGA), long non-coding RNAs (LncRNAs) have been discovered to indicate a prognostic value in some tumors. In that regard, we analyzed lncRNA-sequencing data of KIRP in TCGA, and among 780 differentially-expressed lncRNAs, we selected 37 lncRNAs which were able to assist the prognosis...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339177/trends-in-reporting-histological-subtyping-of-renal-cell-carcinoma-association-with-cancer-center-type
#4
Ted Gansler, Stacey Fedewa, Mahul B Amin, Chun Chieh Lin, Ahmedin Jemal
Histological classification of renal cell carcinoma (RCC) has become increasingly important for clinical management. We identified 295,483 RCC diagnosed from 1998-2014 in the National Cancer Database (NCDB) to examine temporal trends in proportions of RCC with unspecified histology and several specific histologies from the 1998 and 2004 World Health Organization classifications of RCC. Further, multivariable log binomial analysis of 101,062 RCC diagnosed from 2010-2014 was used to determine whether the association of diagnosing/treating facility type and the proportion of unspecified RCC is independent of patient demographic and clinical factors...
January 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29302811/gene-expression-analysis-in-peripheral-blood-cells-of-patients-with-hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome-hlrcc-identification-of-nrf2-pathway-activation
#5
Carolina Arenas Valencia, Liliana Lopez Kleine, Andres M Pinzon Velasco, Andrea Y Cardona Barreto, Clara E Arteaga Diaz
Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) is a very rare disease that is inherited in an autosomal dominant manner. Affected patients may develop from cutaneous and uterine leiomyomas to type 2 papillary renal cell carcinoma (Schmidt and Linehan, Int J Nephrol Renovasc Dis 7:253-260, 2014). HLRCC is caused by germline mutations in the FH gene, which produces the fumarate hydratase protein that participates in the tricarboxylic acid cycle during the conversion of fumarate to malate. In FH-deficient cells, high concentrations of fumarate lead to a series of intricate events, which seem to be responsible for the malignant transformation (Yang et al...
January 4, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29286924/expression-of-cd105-cancer-stem-cell-marker-in-three-subtypes-of-renal-cell-carcinoma
#6
Leili Saeednejad Zanjani, Zahra Madjd, Maryam Abolhasani, Ahmad Shariftabrizi, Arezoo Rasti, Mojgan Asgari
BACKGROUND: CD105 is recently described as a cancer stem cell (CSC) marker. OBJECTIVE: The present study was aimed to investigate the expression and prognostic significance of the CSC marker CD105 in different histological subtypes of renal cell carcinoma (RCC). METHODS: Expression of CD105 was evaluated using immunohistochemistry in RCC samples on tissue microarrays including clear cell RCCs (ccRCCs), papillary, and chromophobe RCCs. The association between CD105 expression and clinicopathological features as well as survival outcomes was determined...
December 20, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29285359/mucinous-tubular-and-spindle-cell-carcinoma-with-a-high-nuclear-grade-and-micropapillary-pattern-a-case-report
#7
Toru Sakatani, Yoshinaga Okumura, Naoto Kuroda, Toshihiro Magaribuchi, Yorika Nakano, Toshiaki Shirahase, Jun Watanabe, Yoji Taki, Mitsuhiko Okigaki, Susumu Ikehara, Yasushi Adachi
Mucinous tubular and spindle cell carcinoma (MTSCC) is rare in renal cell carcinoma (RCC) and usually demonstrates a low nuclear grade and a better prognosis compared with other RCCs. The authors present a case report of MTSCC containing an area of Fuhrman nuclear grade 3, in addition to an area with a micropapillary pattern. An 82-year-old man consulted a hospital due to macrohematuria, and a tumor in the right kidney was detected. The tumor was resected and histologically examined. The tumor consisted of various growth patterns: Elongated tubular structure, a papillary structure containing a micropapillary pattern and solid pattern with spindle cells...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29282004/pathologic-analysis-of-non-neoplastic-parenchyma-in-renal-cell-carcinoma-a-comprehensive-observation-in-radical-nephrectomy-specimens
#8
Xun Wang, Qiang Liu, Wen Kong, Jiwei Huang, Yonghui Chen, Yiran Huang, Jin Zhang
BACKGROUND: This study provides a comprehensive examination of the histological features of non-neoplastic parenchyma in renal cell carcinoma (RCC). We prospectively collected radical nephrectomy (RN) specimens, to analyze the histological changes within peritumoral and distant parenchyma. METHODS: Data of patients who underwent RN and had no known history of diabetes, hypertension, hyperlipidemia, or chronic kidney disease etc., were prospectively collected. Tumor pseudo-capsule (PC), and parenchyma within 2 cm from tumor margin, were pathologically assessed...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29277781/expression-and-distribution-of-galectin-3-in-chromophobe-and-papillary-carcinomas
#9
Andreea Cioca, Diana Muntean, Catalina Bungardean, Marius Raica, Anca Maria Cimpean
BACKGROUND/AIM: Probably due to their low occurrence, chromophobe and papillary renal cell carcinomas are less well characterized and, currently, there are no reliable prognostic markers for this group of patients. Moreover, the optimal therapy for patients with non-clear renal cell carcinoma (RCC) is unknown yet. Although elevated levels of Galectin-3 (Gal-3) were associated with poor prognosis in conventional RCC, the impact of this protein on carcinogenesis of chromophobe and papillary entities has not been previously described...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29250194/rho-gdp-dissociation-inhibitor-%C3%AE-in-renal-cell-carcinoma
#10
Christoph-Alexander von Klot, Natalia Dubrowinskaja, Inga Peters, Jörg Hennenlotter, Axel S Merseburger, Arnulf Stenzl, Markus A Kuczyk, Jürgen Serth
Rho GDP dissociation inhibitor-β (ARHGDIB) is an important mediator of cell signaling. The expression of ARHGDIB is associated with tumor growth and metastasis in a variety of non-genitourinary cancers; however, the role of ARHGDIB in renal cell carcinoma (RCC) has not yet been evaluated. In the present study, tissue samples from 105 patients undergoing surgery for RCC were obtained. The expression levels of ARHGDIB mRNA in normal kidney tissues and in corresponding cancer tissues were analyzed by reverse transcription-quantitative polymerase chain reaction...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29249291/a-multigene-signature-based-on-cell-cycle-proliferation-improves-prediction-of-mortality-within-5-yr-of-radical-nephrectomy-for-renal-cell-carcinoma
#11
Todd M Morgan, Rohit Mehra, Placede Tiemeny, J Stuart Wolf, Shulin Wu, Zaina Sangale, Michael Brawer, Steven Stone, Chin-Lee Wu, Adam S Feldman
BACKGROUND: There is a critical need for improved prognostic discrimination in patients with renal cell carcinoma (RCC) given the increasing awareness that some patients may be managed with active surveillance, while others with higher-risk disease might benefit from adjuvant therapy following surgery. OBJECTIVE: To determine whether a multigene proliferation signature predicts long-term oncologic outcomes in surgically resected RCC. DESIGN, SETTING, AND PARTICIPANTS: The cell cycle proliferation (CCP) score was determined after radical nephrectomy for localized clear cell, papillary, or chromophobe RCC in 565 patients...
December 14, 2017: European Urology
https://www.readbyqxmd.com/read/29243496/increased-expression-of-cd44-is-associated-with-more-aggressive-behavior-in-clear-cell-renal-cell-carcinoma
#12
Leili Saeednejad Zanjani, Zahra Madjd, Maryam Abolhasani, Arezoo Rasti, Oystein Fodstad, Yvonne Andersson, Mojgan Asgari
AIM: Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. METHODOLOGY/RESULTS: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays...
December 15, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29239041/hereditary-and-familial-thyroid-tumours
#13
REVIEW
Julie Guilmette, Vania Nosé
The worldwide incidence of thyroid malignancies has been increasing rapidly. Sensitive imaging modalities and early detection of thyroid lesions have made thyroid cancers the most rapidly increasing cancers in the USA in 2017 (SEER Cancer Facts, 2017). Clinical awareness of potential risk factors, such as inherited thyroid cancers, has allowed earlier recognition of more vulnerable population clusters. Hereditary thyroid neoplasms arising from calcitonin-producing C cells are known as familial medullary thyroid carcinomas (FMTCs), and include well-documented syndromes such as multiple endocrine neoplasia IIA or IIB, and pure familial medullary thyroid carcinoma syndrome...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29230128/sigmoid-colonic-polyp-as-initial-presentation-of-metastatic-papillary-renal-cell-carcinoma
#14
Andrew C Berry, Rahman Nakshabendi, Ozdemir Kanar, Wayne Cai, Mohan Persaud
Background: Upon initial presentation, 25%-30% of patients with renal cell carcinoma have metastatic disease. Metastasis to the gastrointestinal tract is rare, but when it occurs, the large bowel is the least common site. Case Report: A 75-year-old white male presented with vague abdominal symptoms and worsening hemoglobin and hematocrit levels. Colonoscopy revealed a polyp in the distal portion of the sigmoid colon. Histologic and immunohistochemical analysis suggested metastatic papillary renal cell carcinoma...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29215458/recurrence-of-renal-cell-cancer-after-renal-transplantation-in-a-multicenter-french-cohort
#15
Noëlle Cognard, Dany Anglicheau, Philippe Gatault, Sophie Girerd, Marie Essig, Bruno Hurault de Ligny, Yann Le Meur, Franck Le Roy, Cyril Garrouste, Antoine Thierry, Charlotte Colosio, Joseph Rivalan, Johnny Sayegh, Gabriel Choukroun, Bruno Moulin, Sophie Caillard
BACKGROUND: Renal cancer accounts for 3% of adult malignancies; renal cell carcinoma (RCC) represents 80% of all renal cancers, and is characterized by late recurrences. Recurrences after kidney transplantation are associated with a high mortality rate. We aimed to determine if recurrences are linked to tumor characteristics and to delays between diagnosis and transplantation. METHODS: We retrospectively analyzed data from French kidney-transplanted patients with medical histories of pre-transplant renal cancer, focusing on the most common histological subtypes: clear cell and papillary cancers...
December 5, 2017: Transplantation
https://www.readbyqxmd.com/read/29208006/identification-and-validation-of-a-44-gene-expression-signature-for-the-classification-of-renal-cell-carcinomas
#16
Qifeng Wang, Hualei Gan, Chengshu Chen, Yifeng Sun, Jinying Chen, Midie Xu, Weiwei Weng, Liyu Cao, Qinghua Xu, Jian Wang
BACKGROUND: Renal cancers account for more than 3% of all adult malignancies and cause more than 23,400 deaths per year in China alone. The four most common types of kidney tumours include clear cell, papillary, chromophobe and benign oncocytoma. These histological subtypes vary in their clinical course and prognosis, and different clinical strategies have been developed for their management. Some kidney tumours can be very difficult to distinguish based on the pathological assessment of morphology and immunohistochemistry...
December 6, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29207723/papillary-renal-cell-carcinoma-with-tubercular-paraaortic-lymphadenopathy-a-blessing-in-disguise
#17
Bhavna Sharma, Purnima Malhotra, Minakshi Bhardwaj
Incidental Renal Cell Carcinoma (RCC) can be found in a tubercular kidney; however, the vice versa i.e., finding tubercular lymphadenopathy after radical nephrectomy for cancer is exceptionally rare. To the best of our knowledge, only two cases of coexistent renal cell carcinoma and tubercular paraaortic lymphadenopathy have been reported till date. Out of these, only one case was of papillary renal cell carcinoma. We hereby, report a rare case of papillary renal cell carcinoma with coexisting paraaortic tubercular lymphadenopathy, which was upstaged based on radiology findings...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204790/cytoplasmic-expression-of-twist1-an-emt-related-transcription-factor-is-associated-with-higher-grades-renal-cell-carcinomas-and-worse-progression-free-survival-in-clear-cell-renal-cell-carcinoma
#18
Arezoo Rasti, Zahra Madjd, Maryam Abolhasani, Mitra Mehrazma, Leila Janani, Leili Saeednejad Zanjani, Mojgan Asgari
Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. This study aimed to evaluate the expression patterns and clinical significance of Twist1 in renal cell carcinoma (RCC). The cytoplasmic and nuclear expression of Twist1 were examined in 252 well-defined renal tumor tissues, including 173 (68.7%) clear cell renal cell carcinomas (ccRCC), 45 (17...
December 4, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29203116/diagnosis-and-management-of-metastatic-neoplasms-with-unknown-primary
#19
REVIEW
Tilmann Bochtler, Harald Löffler, Alwin Krämer
In cancer of unknown primary (CUP), metastases are clinically and histologically confirmed, but the primary tumor site remains elusive after extensive work-up. CUPs make up for 2-3% of all epithelial malignancies. The two prevailing histologies are adenocarcinomas and undifferentiated carcinomas, whereas squamous cell carcinomas, neuroendocrine carcinomas and rare histologies account for the remaining 10%. The diagnostic work-up in CUP relies strongly on a detailed immunohistological (IHC) analysis in order to characterize the tumor type, nowadays aided by molecular techniques...
November 26, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29184052/notch-transactivates-rheb-to-maintain-the-multipotency-of-tsc-null-cells
#20
Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P Henske, Fabrice Roegiers, Krinio Giannikou, David J Kwiatkowski, Hossein Mansouri, Maciej M Markiewski, Brandon White, Magdalena Karbowniczek
Differentiation abnormalities are a hallmark of tuberous sclerosis complex (TSC) manifestations; however, the genesis of these abnormalities remains unclear. Here we report on mechanisms controlling the multi-lineage, early neuronal progenitor and neural stem-like cell characteristics of lymphangioleiomyomatosis (LAM) and angiomyolipoma cells. These mechanisms include the activation of a previously unreported Rheb-Notch-Rheb regulatory loop, in which the cyclic binding of Notch1 to the Notch-responsive elements (NREs) on the Rheb promoter is a key event...
November 29, 2017: Nature Communications
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