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https://www.readbyqxmd.com/read/28634897/the-effect-of-surgical-technique-and-spacer-texture-on-bone-regeneration-a-caprine-study-using-the-masquelet-technique
#1
Viviane Luangphakdy, G Elizabeth Pluhar, Nicolás S Piuzzi, Jean-Claude D'Alleyrand, Cathy S Carlson, Joan E Bechtold, Jonathan Forsberg, George F Muschler
BACKGROUND: The Masquelet-induced-membrane technique is a commonly used method for treating segmental bone defects. However, there are no established clinical standards for management of the induced membrane before grafting. QUESTIONS/PURPOSES: Two clinically based theories were tested in a chronic caprine tibial defect model: (1) a textured spacer that increases the induced-membrane surface area will increase bone regeneration; and (2) surgical scraping to remove a thin tissue layer of the inner induced-membrane surface will enhance bone formation...
June 20, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28606128/outcomes-of-cement-beads-and-cement-spacers-in-the-treatment-of-bone-defects-associated-with-post-traumatic-osteomyelitis
#2
Xu-Sheng Qiu, Yi-Xin Chen, Xiao-Yang Qi, Hong-Fei Shi, Jun-Fei Wang, Jin Xiong
BACKGROUND: Cement spacers (Masquelet technique) have traditionally been used for the treatment of segmental bone defects. However, no reports have used cement spacers for the treatment of small/partial segmental bone defects associated with osteomyelitis and compared the outcomes with cement beads. METHODS: We retrospectively analysed 40 patients with post-traumatic osteomyelitis of the tibia who underwent treatment, which was performed in two stages. In the first stage, thorough debridement was performed, and bone defects were filled with either antibiotic-impregnated cement beads (bead group, 18 patients) or spacers (spacer group, 22 patients)...
June 12, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28514314/infected-tibia-defect-fractures-treated-with-the-masquelet-technique
#3
Julia Mühlhäusser, Jörg Winkler, Reto Babst, Frank J P Beeres
The treatment after open and infected fractures with extensive soft tissue damage and bone deficit remains a challenging clinical problem. The technique described by Masquelet, using a temporary cement spacer to induce a membrane combined with reconstructive soft tissue coverage, is a possible solution. This study describes the work-up, operative procedure, complications, and the outcome of a homogenous group of patients with an open and infected tibia fracture and segmental bone loss treated with the Masquelet technique (MT)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28499465/current-treatment-of-infected-non-union-after-intramedullary-nailing
#4
H Simpson, S T J Tsang
Non-union is a devastating consequence of a fracture. Non-unions cause substantial patient morbidity with patients suffering from loss of function of the affected extremity, increased pain, and a substantial decrease in the quality of life. The management is often associated with repeated, unsuccessful operations resulting in prolonged hospital stays, which has social and economic consequences to both the patient and the healthcare system. The rates of non-union following intramedullary (IM) nailing vary according to anatomical location...
May 9, 2017: Injury
https://www.readbyqxmd.com/read/28485078/tubular-open-porous-%C3%AE-tcp-plcl-scaffolds-as-guiding-structure-for-segmental-bone-defect-regeneration-in-a-novel-sheep-model
#5
Anne-Marie Pobloth, Hanna Schell, Ansgar Petersen, Katleen Beierlein, Christian Kleber, Katharina Schmidt-Bleek, Georg N Duda
Large segmental bone defect reconstruction with sufficient functional restoration is one of the most demanding challenges in orthopedic surgery. Available regenerative treatment options, as the vascularized bone graft transfer, the Masquelet technique or the Ilizarov distraction osteogenesis, are associated with specific indications and distinct limitations. As an alternative, a hollow cylindrical ceramic-polymer composite scaffold (beta-tricalcium phosphate and poly-lactid co-ε- caprolactone), facilitating a strong surface guiding effect for tissue ingrowth (group 1; n = 6) was investigated here...
May 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28467648/building-better-bone-the-weaving-of-biologic-and-engineering-strategies-for-managing-bone-loss
#6
Andrew M Schwartz, Mara L Schenker, Jaimo Ahn, Nick J Willett
Segmental bone loss remains a challenging clinical problem for orthopaedic trauma surgeons. In addition to the missing bone itself, the local tissues (soft tissue, vascular) are often highly traumatized as well, resulting in a less than ideal environment for bone regeneration. As a result, attempts at limb salvage become a highly expensive endeavor, often requiring multiple operations and necessitating the use of every available strategy (autograft, allograft, bone graft substitution, Masquelet, bone transport, etc...
May 3, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28455479/induced-membrane-technique-for-treating-tibial-defects-gives-mixed-results
#7
R Morris, M Hossain, A Evans, I Pallister
AIMS: This study describes the use of the Masquelet technique to treat segmental tibial bone loss in 12 patients. PATIENTS AND METHODS: This retrospective case series reviewed 12 patients treated between 2010 and 2015 to determine their clinical outcome. Patients were mostly male with a mean age of 36 years (16 to 62). The outcomes recorded included union, infection and amputation. The mean follow-up was 675 days (403 to 952). RESULTS: The mean tibial defect measured 5...
May 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28408083/masquelet-technique-versus-ilizarov-bone-transport-for-reconstruction-of-lower-extremity-bone-defects-following-posttraumatic-osteomyelitis
#8
Kai Tong, Ziyi Zhong, Yulan Peng, Chuangxin Lin, Shenglu Cao, YunPing Yang, Gang Wang
OBJECTIVE: This study was to compare the effectiveness of Masquelet technique versus Ilizarov bone transport in the treatment of lower extremity bone defects following posttraumatic osteomyelitis. PATIENTS AND METHODS: We retrospectively reviewed 39 patients who had been treated at our department for lower extremity bone defects following posttraumatic osteomyelitis. They were 30 males and 9 females with a mean age of 39.18 (range, 12-63 years). The infected bone defects involved 26 tibias and 13 femurs...
April 4, 2017: Injury
https://www.readbyqxmd.com/read/28368930/managing-large-bone-defects-in-children-a-systematic-review-of-the-induced-membrane-technique
#9
Ilaria Morelli, Lorenzo Drago, David A George, Delia Romanò, Carlo L Romanò
Thirty years after its description by Masquelet in 1986, this is the first systematic review aiming to critically evaluate the 'induced membrane technique' effectiveness in achieving bone union in children. Only six papers fulfilled our inclusion criteria (54 patients). The relatively small number of reported cases did not allow a formal meta-analysis. The tibia was the most involved bone. Most frequent aetiologies were congenital pseudoarthrosis and tumour resections. Although effective in achieving bone healing in ∼91% of the patients (bone defects ≤24 cm long), the induced membrane technique was associated with a high rate of complications (54% of patients)...
March 31, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28324799/modified-masquelet-technique-using-allogeneic-umbilical-cord-derived-mesenchymal-stem-cells-for-infected-non-union-femoral-shaft-fracture-with-a-12-cm-bone-defect-a-case-report
#10
Ismail Hadisoebroto Dilogo, Muhammad Rizqi Adhi Primaputra, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem
INTRODUCTION: Non-union due to large bone loss often causes significant long-term morbidity. We incorporate the use of allogeneic umbilical cord-derived mesenchymal stem cells (UC-MSCs) as part of the diamond concept of regenerative medicine in a case of infected non-union fracture. PRESENTATION OF CASE: We reported a 54-year-old female patient presenting with pain on the right thigh. She was previously diagnosed with a closed fracture of the right femoral shaft and underwent four surgeries before finally being referred to Dr...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28289889/finger-reconstruction-using-induced-membrane-technique-and-ulnar-pedicled-forearm-flap-a-case-report
#11
Olivier Herisson, Alain-Charles Masquelet, Levon Doursounian, Alain Sautet, Adeline Cambon-Binder
INTRODUCTION: Injuries referred to as "rollover hands" are associated with multiple and complex lesions of the dorsal aspect of the hand. We present a case of a multitissular reconstruction following a severe injury of the dorsum of the fingers in a 45-year-old woman. MATERIALS AND METHODS: The bone loss reconstruction was performed in two stages using the Masquelet induced membrane technique. In the first stage, a cement spacer was inserted into the phalanx bone defects...
May 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28251059/challenges-of-bone-tissue-engineering-in-orthopaedic-patients
#12
EDITORIAL
Enrique Guerado, Enrique Caso
Bone defects may impede normal biomechanics and the structural stability of bone as an organ. In many cases, the correction of bone defects requires extensive surgical intervention involving the use of bone-grafting techniques and other procedures in which healing is slow, there is a high risk of infection and considerable pain is provoked - with no guarantee of complete correction of the defect. Therefore, the search for surgical alternatives continues to present a major challenge in orthopaedic traumatology...
February 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28238936/guidelines-on-smoking-management-during-the-perioperative-period
#13
Sébastien Pierre, Caroline Rivera, Béatrice Le Maître, Anne-Marie Ruppert, Hervé Bouaziz, Nathalie Wirth, Jacques Saboye, Alain Sautet, Alain Charles Masquelet, Jean-Jacques Tournier, Yves Martinet, Benoît Chaput, Bertrand Dureuil
Smoking is a public health problem of particular importance during the perioperative period, since it exposes patients scheduled for surgery to risk increases of 20% in hospital mortality and 40% in major postoperative complications. In addition, current smoking increases almost all specific surgical complications. The perioperative period offers a genuine opportunity for smoking cessation. The rate of preoperative smoking cessation can be increased significantly by offering behavior management and the prescription of a nicotine substitute before any scheduled surgical intervention...
June 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28220752/putting-3d-modelling-and-3d-printing-into-practice-virtual-surgery-and-preoperative-planning-to-reconstruct-complex-post-traumatic-skeletal-deformities-and-defects
#14
Kevin Tetsworth, Steve Block, Vaida Glatt
3D printing technology has revolutionized and gradually transformed manufacturing across a broad spectrum of industries, including healthcare. Nowhere is this more apparent than in orthopaedics with many surgeons already incorporating aspects of 3D modelling and virtual procedures into their routine clinical practice. As a more extreme application, patient-specific 3D printed titanium truss cages represent a novel approach for managing the challenge of segmental bone defects. This review illustrates the potential indications of this innovative technique using 3D printed titanium truss cages in conjunction with the Masquelet technique...
2017: SICOT-J
https://www.readbyqxmd.com/read/28220260/three-stage-treatment-protocol-for-recalcitrant-distal-femoral-nonunion
#15
Ching-Hou Ma, Yen-Chun Chiu, Yuan-Kun Tu, Cheng-Yo Yen, Chin-Hsien Wu
INTRODUCTION: In this study, we proposed a three-stage treatment protocol for recalcitrant distal femoral nonunion and aimed to analyze the clinical results. MATERIALS AND METHODS: We retrospective reviewed 12 consecutive patients with recalcitrant distal femoral nonunion undergoing our three-stage treatment protocol from January 2010 to December 2014 in our institute. The three-stage treatment protocol comprised debridement of the nonunion site, lengthening to eliminate leg length discrepancy, deformity correction, stabilization with a locked plate, filling of the defect with cement spacer for inducing membrane formation, and bone reconstruction using a cancellous bone autograft (Masquelet technique) or free vascularized fibular bone graft...
April 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28153375/autograft-treated-with-liquid-nitrogen-combined-with-the-modified-masquelet-technique-for-bone-defect-after-resection-of-malignant-bone-tumors-two-case-reports
#16
Tomohiko Moteki, Takashi Yanagawa, Kenichi Saito
No abstract text is available yet for this article.
January 30, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28116272/management-of-large-bone-defects-in-diaphyseal-fractures-by-induced-membrane-formation-by-masquelet-s-technique
#17
R Sivakumar, M Gulam Mohideen, M Chidambaram, T Vinoth, Prahalad Kumar Singhi, V Somashekar
INTRODUCTION: Management of the large gap in long bone fractures is a challenging problem after compound injuries. A novel technique called as Masquelet's technique of "induced membrane formation", is used to bridge a gap of more than 5 cm using bone cement as a spacer in first stage and autologous cancellous bone graft to fill the gap in second stage. CASE PRESENTATION: We present two different and difficult cases with bone defects after open injuries associated with long bone fractures in this paper...
July 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28108960/dual-acting-biofunctionalised-scaffolds-for-applications-in-regenerative-medicine
#18
Camilo Chaves, Chuanyu Gao, Jerome Hunckler, Moustafa Elsawy, Josette Legagneux, Gilles Renault, Alain Charles Masquelet, Achala de Mel
Off the shelf scaffolds for replacing ultra-small diameter vascular grafts are valuable for reconstruction of diseased or damaged vessels. The limitations for such grafts include optimal handling with ready availability of varied lengths of grafts, graft patency with the ability to replace the function of active cellular mechanisms and adequate mechanical properties to maintain physicochemical function. We used a well-established, solvent casting method for potential tissue replacement scaffold fabrication with incorporated bioactive molecules, which we have previously explored to confer haemocompatibility...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28040090/masquelet-technique-myth-or-reality-a-systematic-review-and-meta-analysis
#19
REVIEW
Ilaria Morelli, Lorenzo Drago, David A George, Enrico Gallazzi, Sara Scarponi, Carlo L Romanò
INTRODUCTION: The induced membrane technique (IMT) or Masquelet technique, is a two-step surgical procedure used to treat pseudoarthroses and bony defects. Many authors have introduced variants to the technique. This study aims to compare the surgical variants of IMT and to evaluate its efficacy in achieving infection eradication and bone union. METHODS: A systematic review was carried out following the PRISMA guidelines. PubMed and other medical databases were explored using keywords "Masquelet technique" and "induced membrane technique"...
December 2016: Injury
https://www.readbyqxmd.com/read/28040089/success-rate-and-risk-factors-of-failure-of-the-induced-membrane-technique-in-children-a-systematic-review
#20
REVIEW
Jean-Charles Aurégan, Thierry Bégué, Guillaume Rigoulot, Christophe Glorion, Stéphanie Pannier
The induced membrane technique was designed by Masquelet et al. to address segmental bone defects of critical size in adults. It has been used after bone defects of traumatic, infectious and tumoral origin with satisfactory results. Recently, it has been used in children but, after an initial enthusiasm, several cases of failure have been reported. The purpose of this study was to assess the success rate and the risk factors of failure of the induced membrane for children. We conducted a systematic review of all the studies reporting the results of the induced membrane technique to address bone defects of critical size in children...
December 2016: Injury
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