Maria D Astudillo Potes, Indranath Mitra, Kari Hanson, Emily T Camilleri, Bipin Gaihre, Mahnoor Shafi, Abdelrahman Hamouda, Lichun Lu, Benjamin D Elder
Segmental bone defects, often clinically treated with nondegradable poly(methylmethacrylate) (PMMA) in multistage surgeries, present a significant clinical challenge. Our study investigated the efficacy of 3D printed biodegradable polycaprolactone fumarate (PCLF)/PCL spacers in a one-stage surgical intervention for these defects, focusing on early bone regeneration influenced by spacer porosities. We compared nonporous PCLF/PCL and PMMA spacers, conventionally molded into cylinders, with porous PCLF/PCL spacers, 3D printed to structurally mimic segmental defects in rat femurs for a 4-week implantation study...
March 24, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society