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Masquelet

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https://www.readbyqxmd.com/read/29736214/masquelet-s-induced-membrane-promotes-the-osteogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells-by-activating-the-smad-and-mapk-pathways
#1
Qian Tang, Minji Tong, Gang Zheng, Liyan Shen, Ping Shang, Haixiao Liu
The Masquelet's induced membrane (IM) technique is widely used to treat large segmental bone defects due to its physical priority and biological function. However, the underlying molecular mechanism of the IM on bone formation remains unknown. In the present study, rat bone marrow-derived mesenchymal stem cells (BMSCs) were used as an in vitro model and bone morphogenetic protein 2 (BMP-2) was used as a positive control to evaluate the effects of the IM on the osteogenic differentiation of BMSCs. Although the IM group did not exhibit a significant increase in the expression of Runt-related transcription factor 2 (Runx2), Collagen I (Col I), osteocalcin (OCN) and alkaline phosphatase (ALP) relative to the BMP-2 administration, the IM was considerably effective compared with the untreated group...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29735332/-the-fascio-cutaneous-fibular-island-flap
#2
A-C Masquelet, J Gaillard, A Cambon-Binder, R Mauprivez
The perforators of the fibular artery provide a well vascularised supra fascial network which allows to raise a proximally or a distally based island fascio cutaneous flap with an adipo-fascial pedicle. We present a short series of five cases of this flap for coverage of soft tissue defects involving the region of the knee, the distal third of the leg and the lateral aspect of the heel. All flaps healed entirely without venous congestion. The advantages of the fascio cutaneous fibular island flap are the supine operative position, the preservation of the sural nerve and the lesser saphenous vein and a pivot point which can be located at the middle third of the leg...
May 4, 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29674611/inhibition-of-dll4-notch1-pathway-promotes-angiogenesis-of-masquelet-s-induced-membrane-in-rats
#3
Qian Tang, Haimin Jin, Minji Tong, Gang Zheng, Zhongjie Xie, Shangkun Tang, Jialei Jin, Ping Shang, Huazi Xu, Liyan Shen, Yu Zhang, Haixiao Liu
The Masquelet's induced membrane technique for repairing bone defects has been demonstrated to be a promising treatment strategy. Previous studies have shown that the vessel density of induced membrane is decreased in the late stage of membrane formation, which consequently disrupts the bone healing process. However, relatively little is known about certain mechanisms of vessel degeneration in the induced membrane tissue and whether promotion of angiogenesis in induced membranes can improve bone regeneration...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29595536/the-masquelet-technique-for-thumb-metacarpal-reconstruction-following-trauma-a-case-report
#4
Zachary C Lum, Lily Park, Kathryn E Huff, Mohamed A Ibrahim
CASE: We describe an unusual case of an isolated close-range shotgun injury to the thumb with substantial osseous loss and intact vascularity, followed by treatment with the Masquelet technique and iliac crest tricortical bone autograft reconstruction. CONCLUSION: Gunshot injuries to the thumb with concomitant soft-tissue and osseous loss are devastating. Reconstruction depends on the level of the injury, the severity of the soft-tissue and osseous damage, and the viability of the digit, as well as patient factors, including occupation, physical demands, and expectations...
January 2018: JBJS Case Connector
https://www.readbyqxmd.com/read/29510858/masquelet-technique-the-effect-of-altering-implant-material-and-topography-on-membrane-matrix-composition-mechanical-and-barrier-properties-in-a-rat-defect-model
#5
Natalie Gaio, Alice Martino, Zacharie Toth, J Tracy Watson, Daemeon Nicolaou, Sarah McBride-Gagyi
The Masquelet technique is a surgical procedure to regenerate segmental bone defects. The two-phase treatment relies on the production of a vascularized foreign-body membrane to support bone grafts over three times larger than the traditional maximum. Historically, the procedure has always utilized a bone cement spacer to evoke membrane production. However, membrane formation can easily be effected by implant surface properties such as material and topology. This study sought to determine if the membrane's mechanical or barrier properties are affected by changing the spacer material to titanium or roughening the surface finish...
April 27, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29455511/-treatment-of-gouty-arthritis-of-the-first-metatarsophalangeal-joint-by-masquelet-technique
#6
Cheng-Lin Wang, Jun-Zhong Yang
OBJECTIVE: To study clinical curative effects of a Masquelet technology in the treatment of gouty arthritis in the first metatarsophalangeal joint. METHODS: From February 2012 to May 2016, 7 patients with the gouth arthritis of the first metatarsophalangeal joint were treated by the Masqueket technology. There were 5 males and 2 females, ranging in age from 42 to 58 years old, with an average age of 50 years old. During the regular follow up, the bone healing was assessed by the radiographic imaging, and the orthopaedic foot and ankle Association (AOFAS) ankle function scoring system was used for comprehensive evaluation...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29424019/altering-spacer-material-affects-bone-regeneration-in-the-masquelet-technique-in-a-rat-femoral-defect
#7
Sarah McBride-Gagyi, Zacharie Toth, Daniel Kim, Victoria Ip, Emily Evans, John Tracy Watson, Daemeon Nicolaou
The Masquelet technique depends on pre-development of a foreign-body membrane to support bone regeneration with grafts over three times larger than the traditional maximum. To date, the procedure has always used spacers made of bone cement, which is the polymer polymethyl methacrylate (PMMA), to induce the foreign-body membrane. This study sought to compare (i) morphology, factor expression, and cellularity in membranes formed by PMMA, titanium, and polyvinyl alcohol sponge (PVA) spacers in the Masquelet milieu and (ii) subsequent bone regeneration in the same groups...
February 9, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29409218/use-of-masquelet-s-technique-for-treating-the-first-metatarsophalangeal-joint-in-cases-of-gout-combined-with-a-massive-bone-defect
#8
Feng Liu, Ruo-Kun Huang, Ming Xie, Hao Pan, Jing-Jing Zhao, Bo Lei
BACKGROUND: To examine the safety and efficacy of Masquelet's technique as a surgical method for treating the first metatarsophalangeal joint in cases of gout accompanied by a massive bone defect. METHODS: From January 2010 to January 2016, eleven patients (7 males and 4 females; mean age 33.1 years; range, 23-43 years) received surgical treatment for a first metatarsophalangeal joint tophus which caused a serious bone defect. The first metatarsophalangeal bone defects ranged from 3-6cm, or nearly 50% of the length of normal bone...
April 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29352347/autologous-cell-based-therapy-for-treatment-of-large-bone-defects-from-bench-to-bedside
#9
REVIEW
R Verboket, M Leiblein, C Seebach, C Nau, M Janko, M Bellen, H Bönig, D Henrich, I Marzi
OBJECTIVES: Reconstruction of long segmental bone defects is demanding for patients and surgeons, and associated with long-term treatment periods and substantial complication rates in addition to high costs. While defects up to 4-5 cm length might be filled up with autologous bone graft, heterologous bone from cadavers, or artificial bone graft substitutes, current options to reconstruct bone defects greater than 5 cm consist of either vascularized free bone transfers, the Masquelet technique or the Ilizarov distraction osteogenesis...
January 19, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29330453/calcium-sulfate-induced-versus-pmma-induced-membrane-in-a-critical-sized-femoral-defect-in-a-rat-model
#10
Yun-Fei Ma, Nan Jiang, Xiang Zhang, Cheng-He Qin, Lei Wang, Yan-Jun Hu, Qing-Rong Lin, Bin Yu, Bo-Wei Wang
Aimed to investigate the characteristics of CS-induced membrane in comparison with the PMMA-induced membrane. Cellular components, histological changes, growth factor expressions of IL-6, VEGF, BMP-2, and TGF-β1 in the two induced membranes were compared at 2, 4, 6 and 8 weeks, respectively. We also compared the histological changes at the bone defects between CS and PMMA groups. The structural characteristics of induced membrane were similar between CS and PMMA. Endochondral ossification took place in the CS-induced membrane at 8 week...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29241817/salvage-of-congenital-pseudarthrosis-of-the-tibia-by-the-induced-membrane-technique-followed-by-a-motorised-lengthening-nail
#11
T Pollon, J Sales de Gauzy, T Pham, C Thévenin Lemoine, F Accadbled
An 18-year-old male with neurofibromatosis type I was treated for congenital pseudarthrosis of the tibia using the Masquelet induced-membrane technique with internal fixation by retrograde implantation of a transplantar intramedullary nail. Bone healing was obtained at the expense of malunion with external rotation and 5.5cm of lower limb shortening. A motorised intramedullary-lengthening nail (Fitbone® , Wittenstein, Igersheim, Germany) was implanted. This treatment was successful in correcting the rotational malalignment and limb length discrepancy...
February 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29201370/salvage-of-mangled-upper-extremity-using-the-masquelet-technique-in-a-child-a-case-report
#12
Nabil Alassaf, Amro Alhoukail, Abdullah Alsahli, Ghazi Althubaiti
Aim: To report our experience with the Masquelet concept in a pediatric upper extremity following an open injury to the elbow. Methods: A case report and literature review. Results: An 11-year-old boy was transferred to our institution after a motor vehicle collision. There was a primary loss of the ulnohumeral articulation and the surrounding soft tissues as well as the ulnar nerve. Reconstruction used the Masquelet-induced membrane technique and a soft tissue flap...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29181564/a-cadaver-study-into-the-number-of-fasciotomies-required-to-decompress-the-anterior-compartment-in-forearm-compartment-syndrome
#13
Lionel Benamran, Alain Charles Masquelet
PURPOSE: There is no typical approach for decompression of forearm compartment syndrome, due to contradictory considerations regarding the characteristics of forearm anterior compartment deep fascia. The main purpose of this study was to determine how many fasciae should be opened to fully decompress the forearm anterior compartment. Further, the compliance of the deep anterior compartment was also investigated, to strengthen our results. METHODS: An experimental study of a laboratory model of acute forearm compartment syndrome was performed...
March 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29178906/femoral-nonunion-with-segmental-bone-defect-treated-by-distraction-osteogenesis-with-monolateral-external-fixation
#14
Qun Zhang, Wei Zhang, Zhuo Zhang, Licheng Zhang, Hua Chen, Ming Hao, Junhao Deng, Peifu Tang
BACKGROUND: Currently, the common treatment for femoral nonunion with large segmental bone defect is difficult and complex. The effective surgical methods are rare, include vascularized bone grafting, Masquelet technique and Ilizarov distraction osteogenesis. The objective of this study is to investigate the outcomes of segmental femoral defects treated with monolateral external fixation using the distraction osteogenesis. METHODS: We retrospectively analyzed patients with femoral nonunion with segmental bone defects (> 6 cm) between January 2010 and January 2014 in our single trauma center...
November 25, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29153382/a-pilot-study-alternative-biomaterials-in-critical-sized-bone-defect-treatment
#15
Magdalena Tarchala, Victor Engel, Jake Barralet, Edward J Harvey
BACKGROUND: Critical-sized bone defects are a significant challenge with limited effective reconstructive options. The Masquelet Technique (MT) offers a solution to help restore form and function. Although this technique has produced promising results; a clear mechanism has not been determined. Theories include that the induced membrane has osteogenic potential or the membrane acts as a physical barrier to prevent fibrous tissue ingrowth. We hypothesize the induced membrane acts primarily as a physical barrier and that a synthetic non-biological membrane will allow a comparable amount of bone volume in the defect site...
November 9, 2017: Injury
https://www.readbyqxmd.com/read/29122899/congenital-pseudarthrosis-of-the-clavicle-treated-by-masquelet-technique
#16
Hicham Abdellaoui, Karima Atarraf, Lamiae Chater, My Abderahmane Afifi
Congenital pseudarthrosis of the clavicle (CPC) is a very rare pathology of which over 200 cases have been reported. Usually discovered during the first months of life, CPC is characterised by a definitive bone defect in the middle third of the clavicle. Generally asymptomatic, the pseudarthrosis of the clavicle can cause aesthetic issues and functional symptoms indicating a surgical repair. Different reconstruction techniques have been reported with various complications. We present a 14-year-old boy diagnosed with CPC and concerned about the cosmetic aspect of a swelling of his right clavicle...
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29122282/masquelet-technique-with-external-locking-plate-for-recalcitrant-distal-tibial-nonunion
#17
Ching-Hou Ma, Yen-Chun Chiu, Kun-Ling Tsai, Yuan-Kun Tu, Cheng-Yo Yen, Chin-Hsien Wu
OBJECTIVE: In the present retrospective study, we aimed to analyze the results of treatment for recalcitrant distal tibial nonunion using Masquelet technique with locking plate as a definitive external fixator. MATERIALS: We included 15 consecutive cases of distal tibial nonunion treated at our hospital between January 2012 and December 2015. The reconstructive procedure comprised debridement of the nonunion site, deformity correction, stabilization with an external locked plate, defect filling with cement spacer for inducing membrane formation, and bone reconstruction using a cancellous bone autograft (Masquelet technique)...
December 2017: Injury
https://www.readbyqxmd.com/read/29116576/bridging-hard-callus-at-48%C3%A2-days-in-an-open-femoral-shaft-fracture-with-segmental-defect-treated-with-a-first-stage-masquelet-technique-i-wasn-t-expecting-that
#18
Andrew James Hotchen, Lynne V Barr, Matija Krkovic
The Masquelet technique is a strategy for management of segmental bone defects. It is a two-stage procedure that involves inducing a synovial-like membrane that can be used for a bone graft. Segmental bone defects can occur following trauma and can accompany traumatic brain injury. There is a well-documented, albeit debated, association between traumatic brain injury and increased rate of new bone formation. Here, we present a case of unexpected callus formation in a segmental femoral fracture. The patient had a traumatic brain injury and was treated with the first stage of the Masquelet technique...
November 7, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/29025615/treatment-of-an-atrophic-clavicle-non-union-with-the-chamber-induction-technique-a-case-report
#19
Giorgio Maria Calori, Emilio Luigi Mazza, Alessandra Colombo, Simone Mazzola, Massimiliano Colombo
The gold standard technique for treating non-union of the clavicle is based on corticocancellous bone graft harvested from the iliac crest and fixation with a plate. In cases of large clavicular defects, this surgical procedure becomes ineffective and only a complex bone reconstruction can be considered. In the herein study we report on a clavicular non-union which was associated with a 4cm bone defect that was managed successfully with optimum fixation and the Chamber Induction Technique (C.I.T)-formation of the masquelet membrane- and subsequent biological augmentation with a composite bone graft...
October 2017: Injury
https://www.readbyqxmd.com/read/28938390/induced-membrane-technique-pearls-and-pitfalls
#20
Alain C Masquelet
The induced membrane technique for reconstruction of bone defects has proved its effectiveness and is now widely accepted. The 2 stages procedure, implying a cement spacer in the first stage and a huge bone graft in the second stage, responds to rigorous technical details involving each phase of the procedure. Prerequisites for the technique, cement spacer, bone fixation, time between the 2 stages, grafting, and postoperative course are reported and discussed.
October 2017: Journal of Orthopaedic Trauma
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