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https://www.readbyqxmd.com/read/28231692/risk-and-characteristics-of-postcolonoscopy-interval-colorectal-cancer-after-a-positive-fecal-test-a-nationwide-population-based-study-in-korea
#1
Chang Kyun Lee, Kui Son Choi, Chang Soo Eun, Dong-Il Park, Dong Soo Han, Minjoo Yoon, Mina Suh, Jae Kwan Jun
Purpose: Fecal tests remain a mainstay of population-based colorectal cancer (CRC) screening programs worldwide. However, data on interval CRC (iCRC) arising after follow-up colonoscopy of a positive fecal test are scarce. We conducted a nationwide population-based study to reveal the risk and characteristics of iCRC in this setting. Materials and Methods: We searched the National Cancer Screening Program for CRC database in Korea (2005-2010). Incidence of iCRC within the program was estimated, then Cox proportional-hazards regression analysis was performed to determine the independent predictors of iCRC...
February 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28231632/reliability-and-validity-of-the-chinese-version-of-the-self-care-ability-scale-for-the-elderly
#2
Han Gao, Ulrika Söderhamn, Christina Cliffordson, Lina Guo, Qiyun Guo, Kun Liu
AIMS AND OBJECTIVES: To translate the Self-care Ability Scale for the Elderly into Simplified Chinese, and to test the Chinese version of the scale regarding its reliability and validity among older people. BACKGROUND: Self-care is an important topic in nursing. When assessing older people's self-care ability, it is essential that a reliable and valid instrument is used. DESIGN: This study employed across-sectional design. METHODS: We translated the English version of the Self-care Ability Scale for the Elderly into Simplified Chinese according to Brislin's translation guidelines, and carried out a questionnaire survey among 610 older people, including both community-dwelling people and hospital patients, in Jinzhou City, People's Republic of China...
February 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28231631/commentary-response-frailty-not-just-about-old-people-reply-to-smith-gd-kydd-a-2017-getting-care-of-older-people-right-the-need-for-appropriate-frailty-assessment
#3
Sunita R Jha, Julee Mcdonagh, Caleb Ferguson, Peter S Macdonald, Phillip J Newton
As highlighted in a recent editorial, the ageing population and burden of frailty amongst those aged 60 years and older represents an impending challenge for individuals and health care systems globally (Smith & Kydd 2017). As frailty is largely considered a geriatric syndrome, research has primarily occurred within elderly community dwelling populations (Fried et al. 2001). However, it is important to highlight that not all older people are frail; and conversely not all younger people are non-frail. With frailty research expanding its scope beyond geriatrics over the last 2 decades, our understanding of this syndrome and its complexities has progressed...
February 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28231583/prevalence-of-impaired-kidney-function-in-the-german-elderly-results-from-the-berlin-aging-study-ii-base-ii
#4
Maximilian König, Maik Gollasch, Ilja Demuth, Elisabeth Steinhagen-Thiessen
BACKGROUND: In aging populations with an ever-growing burden of risk factors such as obesity, diabetes, and hypertension, chronic kidney disease (CKD) is on the rise. However, little is known about its exact prevalence among elderly adults, and often albuminuria is not included in the definition of CKD. Moreover, novel equations for the estimated glomerular filtration rate (eGFR) have recently emerged, which have not been applied comprehensively to older adults. Data on CKD awareness among the elderly are sparse...
February 24, 2017: Gerontology
https://www.readbyqxmd.com/read/28231543/date-seed-extract-ameliorates-%C3%AE-amyloid-induced-impairments-in-hippocampus-of-male-rats
#5
Farzaneh Dehghanian, Taj Pari Kalantaripour, Khadijeh Esmaeilpour, Leila Elyasi, Hakime Oloumi, Fatmeh Mehdi Pour, Majid Asadi-Shekaari
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder among the elderly. Because the existing treatments for Alzheimer's disease only offer limited symptomatic alleviation, more efficient therapeutic agents are urgently needed. Date seed is a hepatoprotective and neuroprotective agent. Date seed extract (DSE) has bioactive components like phenolics, flavonoids, and vitamins. In view of the ameliorative effects of DSE against an oxidative injury, the current study was designed to reveal whether DSE has a neuroprotective resource in the rat model of Alzheimer's disease...
February 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28230652/a-case-of-postmortem-canine-depredation
#6
Dennis J Chute, Robert J Bready
We report the case of postmortem animal depredation that produced initial confusion for investigators who responded to the scene. A decomposing elderly woman was found in her presumed home with bilateral upper extremity amputations and craniocerebral trauma. This raised suspicion of foul play. Subsequent investigations together with autopsy led the medical examiner to conclude that the cause of death was natural disease and that those injuries found on her body were produced by at least one of the dogs who shared the premises...
February 23, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28230262/evaluation-of-the-immunogenicity-of-the-dabigatran-reversal-agent-idarucizumab-during-phase-i-studies
#7
Stephen Norris, Steven Ramael, Ippei Ikushima, Wouter Haazen, Akiko Harada, Viktoria Moschetti, Susumu Imazu, Paul A Reilly, Benjamin Lang, Joachim Stangier, Stephan Glund
AIMS: Idarucizumab, a humanized monoclonal anti-dabigatran antibody fragment, is effective in emergency reversal of dabigatran anticoagulation. Pre-existing and treatment-emergent anti-idarucizumab antibodies (antidrug antibodies; ADA) may affect the safety and efficacy of idarucizumab. This analysis characterized the pre-existing and treatment-emergent ADA and assessed their impact on the pharmacokinetics and pharmacodynamics (PK/PD) of idarucizumab. METHODS: Data were pooled from three phase I, randomized, double-blind idarucizumab studies in healthy Caucasian; elderly, renally impaired subjects; and healthy Japanese subjects...
February 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28230198/longitudinal-association-of-hypertension-and-diabetes-mellitus-with-cognitive-functioning-in-a-general-70-year-old-population-the-sonic-study
#8
Hirochika Ryuno, Kei Kamide, Yasuyuki Gondo, Mai Kabayama, Ryosuke Oguro, Chikako Nakama, Serina Yokoyama, Motonori Nagasawa, Satomi Maeda-Hirao, Yuki Imaizumi, Miyuki Takeya, Hiroko Yamamoto, Masao Takeda, Yoichi Takami, Norihisa Itoh, Yasushi Takeya, Koichi Yamamoto, Ken Sugimoto, Takeshi Nakagawa, Saori Yasumoto, Kazunori Ikebe, Hiroki Inagaki, Yukie Masui, Michiyo Takayama, Yasumichi Arai, Tatsuro Ishizaki, Ryutaro Takahashi, Hiromi Rakugi
Both hypertension and diabetes in middle-aged individuals have been suggested to be predictive indicators of cognitive decline. However, the association of hypertension, diabetes and their combination with cognitive functioning is still controversial in older people. The purpose of this study was to investigate the association between cognitive decline and hypertension, diabetes, and their combination in 70-year-old people based on a 3-year longitudinal analysis. Four hundred and fifty-four people aged 70 (±1) years who participated in the Japanese longitudinal cohort study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) were recruited randomly from a general population and were monitored for 3 years...
February 23, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28230070/an-fmri-compatible-force-measurement-system-for-the-evaluation-of-the-neural-correlates-of-step-initiation
#9
Andrea Cristina de Lima-Pardini, Raymundo Machado de Azevedo Neto, Daniel Boari Coelho, Catarina Costa Boffino, Sukhwinder S Shergill, Carolina de Oliveira Souza, Rachael Brant, Egberto Reis Barbosa, Ellison Fernando Cardoso, Luis Augusto Teixeira, Rajal G Cohen, Fay Bahling Horak, Edson Amaro
Knowledge of brain correlates of postural control is limited by the technical difficulties in performing controlled experiments with currently available neuroimaging methods. Here we present a system that allows the measurement of anticipatory postural adjustment of human legs to be synchronized with the acquisition of functional magnetic resonance imaging data. The device is composed of Magnetic Resonance Imaging (MRI) compatible force sensors able to measure the level of force applied by both feet. We tested the device in a group of healthy young subjects and a group of elderly subjects with Parkinson's disease using an event-related functional MRI (fMRI) experiment design...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229970/molecular-analysis-of-the-human-faecal-archaea-in-a-southern-indian-population
#10
Sandya B Rani, Ramadass Balamurugan, Balakrishnan S Ramakrishna
Archaea are an important constituent of the human gut microbiota, but there is no information on human gut archaea in an Indian population. In this study, faecal samples were obtained from different age groups (neonatal babies, preschool children, school-going children, adolescents, adults and elderly) of a southern Indian population, and from a tribal population also resident in southern India). 16S rRNA gene sequences specific to Archaea were amplified from pooled faecal DNA in each group, sequenced, and aligned against the NCBI database...
March 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/28229646/special-nutrition-intervention-is-required-for-muscle-protective-efficacy-of-physical-exercise-in-elderly-people-at-highest-risk-of-sarcopenia
#11
A Molnár, I Jónásné Sztruhár, Á A Csontos, Cs Ferencz, Sz Várbíró, B Székács
Progressive loss of muscle mass and strength is a physiological consequence of aging, and without interventions, it usually deteriorates into sarcopenia. In this study, the hypothesis that combined special nutritional-physiotherapeutical intervention to prevent or reverse this biological deterioration in elderly people was tested. The effects of the regular resistance muscle training (PT, n = 17) alone and the combined exercise + special nutrition therapy containing whey protein and vitamin D (PT + NT, n = 17) were monitored for 3 months in 34 elderly patients (12 men and 22 women; mean age: 66...
September 2016: Physiol Int
https://www.readbyqxmd.com/read/28229506/local-control-strategy-simple-analyses-of-air-pollution-data-can-reveal-heterogeneity-in-longevity-outcomes
#12
Robert L Obenchain, S Stanley Young
Claims from observational studies that use traditional model specification searches often fail to replicate, partially because the available data tend to be biased. There is an urgent need for an alternative statistical analysis strategy, that is not only simple and easily understood but also is more likely to give reliable insights when the available data have not been designed and balanced. The alternative strategy known as local control first generates local, nonparametric effect-size estimates (fair treatment comparisons) and only then asks whether the observed variation in these local estimates can be predicted from potential confounding factors...
February 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28229255/nordic-walking-training-attenuation-of-oxidative-stress-in-association-with-a-drop-in-body-iron-stores-in-elderly-women
#13
Jakub Kortas, Agnieszka Kuchta, Krzysztof Prusik, Katarzyna Prusik, Ewa Ziemann, Sandra Labudda, Agnieszka Ćwiklińska, Ewa Wieczorek, Maciej Jankowski, Jedrzej Antosiewicz
Excess body iron accumulation and oxidative stress has been associated with ageing. Regular exercise has been shown to reduce oxidative stress and induce some changes in iron metabolism. However, the effects of exercise on both of these parameters have been poorly investigated. In our study, 35 elderly women participated in 12 weeks of Nordic walking (NW) training (three times a week). We demonstrated that the training caused a significant reduction in malondialdehyde advanced oxidation protein products-markers of oxidative stress but had no effects on paraoxonase 1 activity...
February 22, 2017: Biogerontology
https://www.readbyqxmd.com/read/28229224/factors-affecting-survival-of-patients-in-the-acute-phase-of-upper-cervical-spine-injuries
#14
Tomonori Morita, Tsuneo Takebayashi, Hideto Irifune, Hirofumi Ohnishi, Suguru Hirayama, Toshihiko Yamashita
INTRODUCTION: In recent years, on the one hand, the mortality rates of upper cervical spine injuries, such as odontoid fractures, were suggested to be not so high, but on the other hand reported to be significantly high. Furthermore, it has not been well documented the relationship between survival rates and various clinical features in those patients during the acute phase of injury because of few reports. This study aimed to evaluate survival rates and acute-phase clinical features of upper cervical spine injuries...
February 22, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28229222/estimation-of-abnormal-temperature-effects-on-elderly-mortality-in-south-korea-using-the-temperature-deviation-index
#15
Giehae Choi, Hyun-Joo Bae, Youn-Hee Lim
Recent studies have revealed that the effect of temperature on mortality has changed over time. One of the major contributors to the changes is adaptation. We aimed to understand the relationship between elderly mortality and temperature anomaly using the temperature deviation index (TDI), which considers exposure history. Summertime (May to September) mortality data from 1996 to 2014 and meteorological data from 1971 to 2014 were obtained for 16 regions covering South Korea. The TDI was defined as the target day's temperature abnormality compared to previous 25 years' apparent temperature (AT)...
February 22, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28229172/external-beam-radiation-therapy-combined-with-limb-sparing-surgery-in-elderly-patients-70%C3%A2-years-with-primary-soft-tissue-sarcomas-of-the-extremities-a%C3%A2-retrospective-analysis
#16
Claudia Andrä, Alexander Klein, Hans Roland Dürr, Josefine Rauch, Lars Hartwin Lindner, Thomas Knoesel, Martin Angele, Andrea Baur-Melnyk, Claus Belka, Falk Roeder
PURPOSE: To report our experience with EBRT combined with limb-sparing surgery in elderly patients (>70 years) with primary extremity soft tissue sarcomas (STS). METHODS: Retrospectively analyzed were 35 patients (m:f 18:17, median 78 years) who all presented in primary situation without nodal/distant metastases (Charlson score 0/1 in 18 patients; ≥2 in 17 patients). Median tumor size was 10 cm, mainly located in lower limb (83%). Stage at presentation (UICC7th) was Ib:3%, 2a:20%, 2b:20%, and 3:57%...
February 22, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28229037/long-term-effects-of-a-ten-year-osteoporosis-intervention-program-in-a-swedish-population-a-cross-sectional-study
#17
Ann-Charlotte Grahn Kronhed, Helena Salminen
The aim of the study was to explore long-term effects seven years after the completion of a ten-year community-based osteoporosis intervention program in Vadstena, Sweden. The association between calcaneal bone mineral density and several life style factors, and the impact of risk factors for sustaining a fracture after the age of 50 were also studied. Previous participants in the intervention group, and matched subjects were invited to calcaneal bone mass measurement by a portable device including the dual X-ray and laser (DXL) technology by Calscan, and to complete a questionnaire in 2006...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28228902/mri-diagnosis-of-herpes-simplex-encephalitis-in-an-elderly-man-with-nonspecific-symptoms
#18
Benjamin J Croll, Zachary M Dillon, Kevin R Weaver, Marna Rayl Greenberg
A 78-year-old male presented to the Emergency Department complaining of a 1-week onset of increasing fatigue and anorexia. The patient was previously well but had a history of depression, chronic diarrhea, and hypertension. His examination was remarkable for mild fever (100.1°F). He had no acute neurologic deficits. The patient felt better after intravenous fluids and was discharged to follow-up with the primary care provider. With no resolution of symptoms and new memory loss, the patient's primary care doctor ordered an MRI which revealed abnormal signal/patchy enhancement of the left temporal lobe indicative (pathognomonic) of herpes simplex encephalitis...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228899/stent-assisted-modified-coil-protection-technique-for-bilobulated-aneurysm-technical-note
#19
Yunsuk Her, Jin Pyeong Jeon, Hyuk Jai Choi, Yong Jun Cho
Endovascular treatment of deeply located bilobulated aneurysms in elderly patients is still challenging because of the acute angulation of the carotid siphon and poor microcatheter support. In particular, generating a frame coil to cover each lobe is difficult in bilobulated aneurysms with narrow isthmus in the fused portion. Here, we report a successfully treated bilobulated aneurysm using a modified coil protection technique with stent assistance.
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228888/bilateral-external-and-internal-pudendal-veins-embolization-treatment-for-venogenic-erectile-dysfunction
#20
Daniel Lee, Eran Rotem, Ronald Lewis, Satyam Veean, Ashwin Rao, Alison Ulbrandt
Erectile dysfunction (ED) or impotence is estimated to affect around 20-30 million men in the United States (Rhoden et al, 2002). Vascular etiology is purported to be the most prevalent cause of ED in the elderly population, with venogenic ED being the most common subtype (Shafik et al, 2007; Rebonato et al, 2014). A patient, who developed severe venogenic ED, was referred to interventional radiology after ineffective pharmaceutical treatments. Selective embolization of bilateral external and internal pudendal veins was performed through accessing the deep dorsal vein of penis...
March 2017: Radiology case reports
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