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Seema Zargar, Abdul-Rahman A Al-Majed, Tanveer A Wani
BACKGROUND: Dependence on antipsycotic drugs like aripriprazole (ARI) is increasing at alarming rate, hence, this study was undertaken to support the hypothesis that supplementation of Citrus paradisi (Grapefruit) juice having high concentration of polyphenols might potentiate and synergize the therapeutic effect of ARI, by increasing its bioavailability and inherent antioxidant potential. These benefits together might decrease the daily dosage of the ARI and thus alleviate the possible side effects of drug...
March 23, 2018: BMC Complementary and Alternative Medicine
Michael Dennis, Laura Shine, Ann John, Amanda Marchant, Joanna McGregor, Ronan A Lyons, Sinead Brophy
INTRODUCTION: Over recent years there has been growing evidence of increased risk of mortality associated with antipsychotic use in older people with dementia. Although this concern combined with limited evidence of efficacy has informed guidelines restricting antipsychotic prescription in this population, the use of antipsycotics remains common. Many published studies only report short-term outcomes, are restricted to examining mortality and stroke risk or have other limitations. The aim of this study was to assess adverse outcomes associated with the use of antipsychotics in older people living with dementia in Wales (UK)...
June 2017: Neurology and Therapy
Luis Ricardo Peroza, Larissa Finger Schaffer, Catiuscia Molz De Freitas, Caroline Queiroz Leal, Mayara Calegaro Ferrari, Marta Maria Frescura Duarte, Roselei Fachinetto
Antipsychotic drugs have been used in the treatment of schizophrenia and their long-term use can cause movement disorders, such as tardive dyskinesia (TD) in humans mainly typical ones such as haloperidol. Neuroinflammation has been implicated to the use of antipsychotics besides its participation in TD remains unclear. Thus, the aim of this study was to investigate the relation of cytokines with vacuous chewing movements (VCMs) in rats comparing typical and atypical antipsychotics. Rats were treated with haloperidol or risperidone for 28 days...
September 2016: Neurochemical Research
Pinar Altiaylik Ozer, Ugur Emrah Altiparmak, Nurten Unlu, Dicle Oncel Hazirolan, Remzi Kasim, Sunay Duman
BACKGROUND: To determine and compare the incidence of intraoperative floppy iris syndrome (IFIS) features in patients using tamsulosin, and other chronic medications. METHODS: We prospectively studied patients who underwent phacoemulsification (PE) between March 2006 and October 2007 on use of tamsulosin or a single medication like antihypertansive (AH), antiaggregant (AAg), antipsycotic (AP) or oral antidiabetic (OAD). Patients were grouped as tamsulosin users (Group 1), previous tamsulosin users (Group 2), chronic medication users (AH, AAg, AP or OAD) (Group 3) and patients with no medication (Group 4)...
April 2013: Current Eye Research
Paolo Maggi, Biagio Solarino, Paola Cassano, Lucia Tattoli, Armando Leone, Eloisa Maselli, Gioacchino Angarano
BACKGROUND: Clarithromycin is a widely used antibiotic, especially prescribed for the treatment of respiratory tract infections, The drug is generally well tolerated. It is described as a very rare cause of fulminant liver failure. CASE PRESENTATION: Herein we report a case of fatal fulminant hepatitis in a young patient. In his past history the patient presented documented episodes of hypertransaminasemia. CONCLUSIONS: This case confirms that clarithromycin although very rarely, can be a cause of fulminant hepatitis, especially in patients with pre-existing liver damage...
February 2013: Immunopharmacology and Immunotoxicology
Sakiko Uchizaki, Chieko Nakagawa, Hisako Okada, Mizuki Taniguchi, Shigehito Sato
A 32-year-old primipara, who had been diagnosed as schizophrenia for a year and with good control of the disease by olanzapine administration, requested epidural labor analgesia. Olanzapine is an atypical antipsychotic, and is contraindicated to use with epinephrine, because the a receptor antagonistic action of olanzapine decreases the blood pressure in combination with epinephrine. Hypotention is one of the major complications during the labor epidural analgesia. In addition, this patient is at high risk of hypotension under antipsycotic medication...
August 2010: Masui. the Japanese Journal of Anesthesiology
Vincenzo Cesario
A case of serious undesirable, effect arisen in a 24-year old male treated with intravenous injection of haloperidol, is presented. The patient has been affected by acute psychosis and was treated with intravenous injection of haloperidol, successively a serious uneasiness with muscular rigor, perspiration, high blood-pressure, serious shortness of breath with cyanosis appeared. This case arouses interest for an unusual symptomatology and for a difficult diagnostical framing too, because was too much serious to consider it a simple acute extrapiramidal crisis, however without all characteristics to consider it a neuroleptic malignant syndrome...
March 2008: Recenti Progressi in Medicina
A Kumar, D Strech
BACKGROUND: Zuclopenthixol dihydrochloride, given orally, is commonly used for managing the signs and symptoms of schizophrenia. OBJECTIVES: To determine the effects of zuclopenthixol dhydrochloride for treatment of schizophrenia. SEARCH STRATEGY: We searched the Cochrane Schizophrenia Group's register (December 2004). This register is compiled of methodical searches of BIOSIS, CINAHL, Dissertation abstracts, EMBASE, LILACS, MEDLINE, PSYNDEX, PsycINFO, RUSSMED, Sociofile, supplemented with hand searching of relevant journals and numerous conference proceedings...
October 19, 2005: Cochrane Database of Systematic Reviews
J L Figuerido, M Gutiérrez, A González Pinto, J Ballesteros, F Ramírez, E Elizagarate, R González Oliveros, P López, J L Pérez de Heredia
INTRODUCTION AND OBJECTIVES: The temporal stability of the positive and negative symptoms in schizophrenia deserves a special interest due to its consequences in the outcome and the treatment of the disease. This study determines the temporal stability of positive/negative subtypes in schizophrenia during the acute phase. MATERIAL AND METHODS: This is a clinical, observational and prospective study of a dynamic cohort of patients with acute exacerbation of schizophrenia defined by DSM III-R criteria...
September 1997: Actas Luso-españolas de Neurología, Psiquiatría y Ciencias Afines
M Lazzarin, F Benati, V Cesario
A case of rhabomyolysis with attendant severe acute renal failure, arisen in a 59-year-old male treated with haloperidol-decanoate, is presented. The patient has been affected by paranoia schizophrenia since childhood, and he was treated with electroshock and successively with neuroleptics p.o. Four years before our observation, a therapy with haloperidol decanoate (50 mg i.m. monthly) was started. After some time, catatonic like episodes appeared, which got more and more frequent, until they appeared weekly...
September 1996: Recenti Progressi in Medicina
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