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C C Wu, Y H Chen, T H Yang, K N Lin, S Y Lee, T C Liu, C J Hsu
Congenital ossicular chain anomalies are rare, but are clinically important because hearing loss in most cases is correctable by appropriate surgical interventions. The great diversity in anatomic variations makes congenital ossicular chain anomalies a surgical challenge for otologists. Theoretically, endoscopic surgery might be suitable for management of congenital ossicular chain anomalies by improving visualization of lesions and preserving uninvolved anatomic structures as compared to conventional microscopic surgery...
October 19, 2016: Clinical Otolaryngology
Christian Güldner, Isabell Diogo, Eva Bernd, Stephanie Dräger, Magis Mandapathil, Afshin Teymoortash, Hesham Negm, Thomas Wilhelm
Cone beam computed tomography (CBCT, syn. digital volume tomography = DVT) was introduced into ENT imaging more than 10 years ago. The main focus was on imaging of the paranasal sinuses and traumatology of the mid face. In recent years, it has also been used in imaging of chronic ear diseases (especially in visualizing middle and inner ear implants), but an exact description of the advantages and limitations of visualizing precise anatomy in a relevant number of patients is still missing. The data sets of CBCT imaging of the middle and inner ear of 204 patients were analyzed regarding the visualization of 18 different anatomic structures...
October 17, 2016: European Archives of Oto-rhino-laryngology
Thomas Zahnert, Marie-Luise Metasch, Hannes Seidler, Matthias Bornitz, Nicoloz Lasurashvili, Marcus Neudert
HYPOTHESIS: Electromagnetical excitation of ossicular vibration is suitable for middle ear transmission measurements in the experimental and clinical setting. Thereby, it can be used as a real-time monitoring system for quality control in ossiculoplasty. BACKGROUND: Positioning and coupling of middle ear prosthesis are a precondition for good postoperative hearing results, but at the same time completely dependent upon the surgeon's subjective judgment during surgery...
October 4, 2016: Otology & Neurotology
Emmy Verheij, Henricus G X M Thomeer, Frank A Pameijer, Vedat Topsakal
Van Maldergem syndrome (VMS) is a very rare syndrome that was first described in 1992. The main features of this syndrome comprise intellectual disability, blepharo-naso-facial malformation, and hand anomalies. Almost all nine described patients have been shown to be affected by conductive hearing impairment attributed to microtia, and atresia of the outer ear canal. Here, we present a VMS patient with congenital malformations of the middle ear as the main reason for severe conductive bilateral hearing impairment...
October 14, 2016: American Journal of Medical Genetics. Part A
Rensa Chen, Martin Schwander, Mary F Barbe, Marion M Chan
Globally, a body of comparative case-control studies suggests that rheumatoid arthritis (RA) patients are more prone to developing hearing loss (HL). However, experimental evidence that supports this hypothesis is still lacking because the human auditory organ is not readily accessible. The aim of this study was to determine the association between bone damage to the ossicles of the middle ear and HL, using a widely accepted murine model of collagen-induced arthritis (RA mice). Diarthrodial joints in the middle ear were examined with microcomputer tomography (microCT), and hearing function was assessed by auditory brainstem response (ABR)...
2016: PloS One
Ruqqia Shafi Minhas, M Yunus Khan
OBJECTIVE: To determine the effect of glucose administration on the development of sclera in the chick embryo Gallus domesticus. STUDY DESIGN: Experimental study. PLACE AND DURATION OF STUDY: Anatomy Department, CPSPRegional Centre, Islamabad, from January 2013 to January 2014. METHODOLOGY: The study was carried out in two main groups, control Aand experimental B, which were subdivided into three subgroups comprising 30 eggs each...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Ana Castro Sousa, Vânia Henriques, Jorge Rodrigues, Rui Fonseca
BACKGROUND AND OBJECTIVES: The goal of ossiculoplasty is to improve hearing. Successful ossiculoplasty depends on several factors. This retrospective study was carried out to analyze hearing results of ossiculoplasty in ears with chronic otitis media (COM) and evaluate clinical outcomes and factors predictive of hearing improvement. SUBJECTS AND METHODS: We reviewed the results of 153 patients with COM (with cholesteatoma (COMC) and without cholesteatoma (COMWC)) who underwent ossiculoplasty between January of 2002 to December of 2011...
September 20, 2016: Acta Otorrinolaringológica Española
Mario Milazzo, Serena Danti, Francesco Inglese, Godfried Jansen van Vuuren, Vera Gramigna, Gabriella Bonsignori, Andrea De Vito, Luca Bruschini, Cesare Stefanini, Stefano Berrettini
This study shows the fabrication of innovative ossicular replacement prostheses (ORPs) based on banked cortical bone using computer numerically controlled ultraprecision micromilling, as a substantial improvement of "second generation" ORPs. Our aim is to combine optimal middle ear compatibility and surgical manageability in a single device, by releasing off-the-shelf homograft ORPs provided with the appealing features of synthetic ORPs, such as lightness, safety, measurement accuracy, surface decoration, and geometric plasticity...
September 23, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Marcus Neudert, Matthias Bornitz, Nikoloz Lasurashvili, Uwe Schmidt, Thomas Beleites, Thomas Zahnert
HYPOTHESIS: Prosthesis' length creates tension in ossicular reconstructions, which directly effects the middle ear sound transmission. BACKGROUND: Relatively long prostheses are often used to stabilize the middle ear reconstruction to prevent dislocation. Thereby, tension on the flexible components such as the tympanic membrane (TM) and the annular ligament (AL) is increased. Only little is known on the amount of displacement-related stiffening of the TM and AL, as well as the consecutive reduction in middle ear transfer function (METF)...
October 2016: Otology & Neurotology
Martin Grossöhmichen, Rolf Salcher, Klaus Püschel, Thomas Lenarz, Hannes Maier
The standard method to determine the output level of acoustic and mechanical stimulation to the inner ear is measurement of vibration response of the stapes in human cadaveric temporal bones (TBs) by laser Doppler vibrometry. However, this method is reliable only if the intact ossicular chain is stimulated. For other stimulation modes an alternative method is needed. The differential intracochlear sound pressure between scala vestibuli (SV) and scala tympani (ST) is assumed to correlate with excitation. Using a custom-made pressure sensor it has been successfully measured and used to determine the output level of acoustic and mechanical stimulation...
2016: BioMed Research International
Wei Ren, Fei Ji, Jialing Zeng, Qingqing Hao, Riyuan Liu, Guangyu Xu, Yan Yan, Miao Zhang, Hui Zhao, Shiming Yang
CONCLUSION: This method might be an effective intra-operative way to access hearing threshold under general anesthesia in the operating room. OBJECTIVE: To develop an intra-operative hearing monitoring method for surgeons to access hearing threshold under general anesthesia in the operating room. METHOD: System establishment and calibration was done firstly. Normal hearing (NH) and conductive hearing loss (CHL) participants were recruited...
September 6, 2016: Acta Oto-laryngologica
Bruno Areias, Carla Santos, Renato M Natal Jorge, Fernanda Gentil, Marco Pl Parente
The ear is one of the most complex organs in the human body. Sound is a sequence of pressure waves, which propagates through a compressible media such as air. The pinna concentrates the sound waves into the external auditory meatus. In this canal, the sound is conducted to the tympanic membrane. The tympanic membrane transforms the pressure variations into mechanical displacements, which are then transmitted to the ossicles. The vibration of the stapes footplate creates pressure waves in the fluid inside the cochlea; these pressure waves stimulate the hair cells, generating electrical signals which are sent to the brain through the cochlear nerve, where they are decoded...
September 2, 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Matthew D Cox, Quinn A Dunlap, Aaron Trinidade, John L Dornhoffer
OBJECTIVES: To assess long-term outcomes after secondary mastoid obliteration. STUDY DESIGN: Case series with chart review. SETTING: Tertiary care center. PATIENTS: Adult patients (20-80 yr of age) undergoing secondary mastoid obliteration. OUTCOME MEASURES: Hearing results (improvement in pure-tone average air-bone gap [PTA-ABG] from baseline) at the time of postoperative audiometry and at least 5 years after surgery, anatomic outcomes (rate of successful tympanic membrane graft healing), and the incidences of observed complications...
October 2016: Otology & Neurotology
Hiroki Koizumi, Hideaki Suzuki, Rintaro Kawaguchi, Koichi Hashida, Nobusuke Hohchi, Jun-Ichi Ohkubo, Takahisa Tabata, Takuro Kitamura
CONCLUSIONS: Osteoclasts are unlikely to be involved in bone resorption in middle ear cholesteatoma. OBJECTIVE: The authors searched for osteoclasts in undecalcified bone sections in patients with middle ear cholesteatoma to determine whether and to what extent these cells are involved in this disease. METHODS: Twelve patients, eight men and four women, aged 30-87 years, who underwent tympanomastoidectomy were enrolled. Six patients had primary acquired middle ear cholesteatoma (cholesteatoma group) and the other six patients had other otologic diseases including otosclerosis, non-cholesteatomatous chronic otitis media, adhesive otitis media, perilymphatic fistula and ossicular malformation (control group)...
August 30, 2016: Acta Oto-laryngologica
Jeon Mi Lee, Jinsei Jung, In Seok Moon, Sung Huhn Kim, Jae Young Choi
OBJECTIVES/HYPOTHESIS: We compared the audiologic benefits of active middle ear implants with those of passive middle ear implants with hearing aids in mixed hearing loss, and also compared the outcomes of stapes vibroplasty with those of round window vibroplasty. STUDY DESIGN: Retrospective chart review. METHODS: Thirty-four patients with mixed hearing loss due to chronic otitis media were treated with a middle ear implant. Of these, 15 were treated with a passive middle ear implant (conventional ossiculoplasty with a partial ossicular replacement prosthesis), nine with an active middle ear implant coupling to the stapes, and 10 with an active middle ear implant coupling to the round window...
August 25, 2016: Laryngoscope
Yoon Chan Rah, Ji Young Lee, Myung-Whan Suh, Moo Kyun Park, Jun Ho Lee, Sun O Chang, Seung-Ha Oh
OBJECTIVE: To determine the optimal surgical approach for cochlear implantation (CI) preoperatively based on the spatial relation of a displaced facial nerve (FN) and middle ear structures and to analyze clinical outcomes of CHARGE syndrome. METHODS: Facial nerve displacement and associated deviation of inner ear structures were analyzed in 13 patients (17 ears) with CHARGE syndrome who underwent CI. Surgical accessibility through the facial recess was assessed based on anatomical landmarks...
November 2016: Annals of Otology, Rhinology, and Laryngology
Kazuhiko Takeuchi, Masako Kitano, Hiroshi Sakaida, Sawako Masuda
The objective of this paper was to describe the clinical and otological findings in multiple members of a family with congenital glaucoma, cardiac anomaly, and conductive hearing loss due to ossicular chain anomalies. We performed a retrospective review of the medical charts and otological materials of multiple members of the same family. Congenital glaucoma and hearing loss were inherited by the proband and her daughter, son, and mother, suggesting autosomal dominant inheritance. The son and daughter also showed atrial septal defects...
August 20, 2016: Auris, Nasus, Larynx
Jessica A Carr, Tulio A Valdez, Oliver T Bruns, Moungi G Bawendi
Visualizing structures deep inside opaque biological tissues is one of the central challenges in biomedical imaging. Optical imaging with visible light provides high resolution and sensitivity; however, scattering and absorption of light by tissue limits the imaging depth to superficial features. Imaging with shortwave infrared light (SWIR, 1-2 μm) shares many advantages of visible imaging, but light scattering in tissue is reduced, providing sufficient optical penetration depth to noninvasively interrogate subsurface tissue features...
September 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
Hamid R Djalilian, Hossein Mahboubi, Yarah M Haidar, Peyton Paulick, Mark W Merlo, Mark Bachman
OBJECTIVES/HYPOTHESIS: To develop a novel completely-in-the-canal device capable of directly driving the tympanic membrane (TM) and ossicular chain from the ear canal. STUDY DESIGN: Development and feasibility study. METHODS: A voice coil actuator design was developed to drive the TM. Bench testing of the device using laser Doppler vibrometry (LDV) and sound recording was performed. Temporal bone studies using LDV were performed using different designs of the contact tip-TM interface to find the most efficient method of sound transmission...
August 22, 2016: Laryngoscope
Antoniu-Oreste Gostian, Jean-Marc Kouamé, Martin Bremke, Magdalene Ortmann, Karl-Bernd Hüttenbrink, Dirk Beutner
Importance: Multiple techniques for a more secure and stable anchoring of the foot of a total ossicular replacement prosthesis (TORP) on the footplate have been proposed. To address this issue, a technique was developed that fits a cartilage shoe into the oval niche to guide the base of the prosthesis into a preformed central perforation. Objective: To evaluate the long-term results of the cartilage shoe technique used to anchor a titanium TORP on the stapes footplate in patients after type III tympanoplasty...
August 18, 2016: JAMA Otolaryngology—Head & Neck Surgery
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