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https://www.readbyqxmd.com/read/29295590/proposal-of-a-novel-natural-biomaterial-the-scleral-ossicle-for-the-development-of-vascularized-bone-tissue-in-vitro
#1
Marta Checchi, Jessika Bertacchini, Giulia Grisendi, Alberto Smargiassi, Antonella Sola, Massimo Messori, Carla Palumbo
Recovering of significant skeletal defects could be partially abortive due to the perturbations that affect the regenerative process when defects reach a critical size, thus resulting in a non-healed bone. The current standard treatments include allografting, autografting, and other bone implant techniques. However, although they are commonly used in orthopedic surgery, these treatments have some limitations concerning their costs and their side effects such as potential infections or malunions. On this account, the need for suitable constructs to fill the gap in wide fractures is still urgent...
December 25, 2017: Biomedicines
https://www.readbyqxmd.com/read/29286959/congenital-quintus-valgus-an-extremely-rare-anomaly-a-case-report
#2
Ali J Electricwala, Jaffer T Electricwala
CASE: We present an unusual case of unilateral congenital quintus valgus of the left foot (congenital lateral deviation of the fifth [little] toe) in a 1.5-year-old boy. The child had no other congenital malformations. Radiographs revealed the abnormal presence of 2 accessory phalangeal ossicles in the fourth web space, leading to lateral deviation of the fifth toe. Remarkably, the ossicles of the middle and distal phalanges of the fifth toe were absent. Surgical excision of the accessory ossicles was performed, and correction of the deformity was achieved...
October 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29273266/in-vitro-and-in-vivo-measurement-of-the-animal-s-middle-ear-acoustical-response-by-partially-implantable-fiber-optic-sensing-system
#3
Zoran Djinović, Robert Pavelka, Miloš Tomić, Georg Sprinzl, Hanns Plenk, Udo Losert, Helga Bergmeister, Roberto Plasenzotti
The main obstacle in realization of a totally implantable hearing aid is a lack of reliable implantable microphone. In this paper we have described a potentially miniature fiber-optic vibrometer based on a modified Michelson interferometer, designed to serve as a middle-ear microphone for totally implantable cochlear- or middle-ear hearing aids. A model of the sensing system was used for in-vitro and in-vivo investigation of acoustical response of sheep's middle-ear ossicles. Surgical and implantation procedure of introducing the sensing optical fiber into the middle-ear and its aiming at the incus was investigated and described here in detail...
December 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29245757/-i-scoliorhapis-i-i-stepanovi-i-new-species-of-sea-cucumber-from-the-north-west-pacific-holothuroidea-synaptida-chiridotidae-taeniogyrinae-%C3%A2-and-some-remarks-on-the-genus-i-scoliorhapis-i
#4
Alexey V Smirnov, Elena G Panina, Nadezhda P Sanamyan, Karen E Sanamyan
New species Scoliorhapis stepanovi has been collected from depths of 10-23 m on the sandy bottom of Avacha Bay (east coast of Kamchatka), Paramushir Island (North Kuril Islands), and Matua Island (Middle Kuril Islands). It is unique in having sigmoid ossicles in the body wall with points at both ends (without an open-eye, and with the two points lying in a perpendicular plane). Such sigmoids do not occur in any other taeniogyrinid species. The two-pointed sigmoids are 80-115 µm in length, and are scattered in the body wall and not clustered...
October 20, 2017: Zootaxa
https://www.readbyqxmd.com/read/29245687/a-new-species-of-i-chiridota-i-echinodermata-holothuroidea-apodida-chiridotidae-from-japan-and-first-record-of-i-c-rigida-i-from-japan
#5
Yusuke Yamana, Hayato Tanaka
A new apodid sea cucumber, Chiridota impatiens sp. nov., is described from the intertidal zone of Okinawa, Japan, and C. rigida Semper, 1867 is also described from the intertidal zone of Wakayama, as new to Japan. C. impatiens sp. nov. is approximately 60-70 mm, with 12 tentacles and 4-7 pairs of digits per tentacle, red or reddish brown in living specimens. The tentacles contain curved rod ossicles, with spinous processes and many branches in C. rigida, however, in C. impatiens sp. nov., the curved rod ossicles are crescent-shaped, sometimes distally, with spinous processes and rarely a few branches on the circumference...
October 31, 2017: Zootaxa
https://www.readbyqxmd.com/read/29214174/feasibility-of-round-window-stimulation-by-a-novel-electromagnetic-microactuator
#6
Wouter Johannes van Drunen, Mathias Mueller, Anatoly Glukhovskoy, Rolf Salcher, Marc Christopher Wurz, Thomas Lenarz, Hannes Maier
Introduction: Most implantable hearing aids currently available were developed to compensate the sensorineural hearing loss by driving middle ear structures (e.g., the ossicles). These devices are successfully used in round window (RW) stimulation clinically, although this was initially not the intended use. Here, a novel microactuator, specifically designed for RW stimulation, was tested in human temporal bones to determine actuator performance and applicability. Methods: Stapes footplate response to RW stimulation was determined experimentally in human temporal bones and the obtained sound pressure output level was estimated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29210944/stapes-release-in-tympanosclerosis
#7
Es-Hak Bedri, Nebiat Teferi, Miriam Redleaf
: Tympanosclerosis in the middle ear space is common in Ethiopia and often involves the ossicles and particularly the stapes. Ear operations in Ethiopia are relatively expensive in this country of limited medical resources and a low average living wage. In this setting, 2-stage operations using prostheses become prohibitively expensive. Therefore, the recommended 2-stage approach for tympanic membrane perforation with tympanosclerosis and stapes fixation is impractical for Ethiopia.We present a series of 67 patients who had a single stage tympanoplasty, removal of tympanosclerosis from the stapes suprastructure, and ossicular chain reconstruction using ossicular interposition...
November 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29210090/towards-understanding-the-dose-and-timing-effect-of-hydrocortisone-treatment-on-the-scleral-ossicle-system-within-the-chicken-eye
#8
Christine L Hammer, Tamara A Franz-Odendaal
Previous work, almost four decades ago, showed that hydrocortisone (HC) treatment reduces the number of skeletogenic condensations that give rise to the scleral ossicles in the chicken eye. The scleral ossicles are a ring of overlapping intramembranous bones, the sclerotic ring, and are present in most reptiles, including birds. The scleral condensations that give rise to the scleral ossicles are induced by a series of overlying thickenings (or papillae) of the conjunctival epithelium. Here, we further explore the effects of altering the dosage and timing of HC treatment on the morphology and number of skeletogenic condensations and conjunctival papillae...
December 6, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29205455/the-middle-and-inner-ears-of-the-palaeogene-golden-mole-namachloris-a-comparison-with-extant-species
#9
Matthew J Mason, Nigel C Bennett, Martin Pickford
Many living species of golden moles (Chrysochloridae) have greatly enlarged middle ear ossicles, believed to be used in the detection of ground vibrations through inertial bone conduction. Other unusual features of chrysochlorids include internally coupled middle ear cavities and the loss of the tensor tympani muscle. Our understanding of the evolutionary history of these characteristics has been limited by the paucity of fossil evidence. In this article, we describe for the first time the exquisitely preserved middle and inner ears of Namachloris arenatans from the Palaeogene of Namibia, visualised using computed tomography, as well as ossicles attributed to this species...
December 4, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29192304/association-of-hearing-loss-and-otologic-outcomes-with-fibrous-dysplasia
#10
Alison M Boyce, Carmen Brewer, Timothy R DeKlotz, Christopher K Zalewski, Kelly A King, Michael T Collins, H Jeffrey Kim
Importance: Fibrous dysplasia (FD) and McCune-Albright syndrome (MAS) are rare bone and endocrine disorders in which expansile fibro-osseous lesions result in deformity, pain, and functional impairment. The effect of FD on hearing and otologic function has not been established. Objectives: To characterize audiologic and otologic manifestations in a large cohort of individuals with FD/MAS and to investigate potential mechanisms of hearing loss. Design, Setting, and Participants: In this natural history study, individuals with craniofacial FD seen at a clinical research center underwent clinical, biochemical, computed tomographic, audiologic, and otolaryngologic evaluations...
November 30, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29190487/minimally-invasive-laser-vibrometry-mivib-with-a-floating-mass-transducer-a-new-method-for-objective-evaluation-of-the-middle-ear-demonstrated-on-stapes-fixation
#11
Jeremy Wales, Kilian Gladiné, Paul Van de Heyning, Vedat Topsakal, Magnus von Unge, Joris Dirckx
Ossicular fixation through otosclerosis, chronic otitis media and other pathologies, especially tympanosclerosis, are treated by surgery if hearing aids fail as an alternative. However, the best hearing outcome is often based on knowledge of the degree and location of the fixation. Objective methods to quantify the degree and position of the fixation are largely lacking. Laser vibrometry is a known method to detect ossicular fixation but clinical applicability remains limited. A new method, minimally invasive laser vibrometry (MIVIB), is presented to quantify ossicle mobility using laser vibrometry measurement through the ear canal after elevating the tympanic membrane, thus making the method feasible in minimally invasive explorative surgery...
November 20, 2017: Hearing Research
https://www.readbyqxmd.com/read/29184270/recurrent-psammomatoid-juvenile-ossifying-fibroma-with-aneurysmal-bone-cyst-an-unusual-case-presentation
#12
Swati S Gotmare, Avinash Tamgadge, Sandhya Tamgadge, Kashmira S Kesarkar
Juvenile ossifying fibroma (JOF) is a rare, benign, locally aggressive entity of the extragnathic craniofacial bones with a high tendency towards recurrence. Two distinctive microscopic patterns of juvenile ossifying fibroma have been described: a trabecular juvenile ossifying fibroma (TrJOF) and a psammomatoid juvenile ossifying fibroma (PJOF). Psammomatoid variant is predominantly a craniofacial lesion and occurs rarely in the jaws. The pathognomonic histopathologic feature is the presence of spherical ossicles, which are similar to psammoma bodies...
November 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29157881/deformation-of-avian-middle-ear-structures-under-static-pressure-loads-and-potential-regulation-mechanisms
#13
Raf Claes, Pieter G G Muyshondt, Joris J J Dirckx, Peter Aerts
Static pressure changes can alter the configuration and mechanical behavior of the chain of ossicles, which may affect the acoustic transfer function. In mammals, the Eustachian tube plays an important role in restoring ambient middle ear pressure, hence restoring the acoustic transfer function and excluding barotrauma of the middle and inner ear. Ambient pressure fluctuations can be potentially extreme in birds and due to the simple structure of the avian middle ear (one ossicle, one muscle), regulation of the middle ear pressure via reflexive opening of the pharyngotympanic tube appears all the more important...
November 7, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/29149722/effects-of-middle-ear-quasi-static-stiffness-on-sound-transmission-quantified-by-a-novel-3-axis-optical-force-sensor
#14
Ivo Dobrev, Jae Hoon Sim, Baktash Aqtashi, Alexander M Huber, Thomas Linder, Christof Röösli
BACKGROUND: Intra-operative quantification of the ossicle mobility could provide valuable feedback for the current status of the patient's conductive hearing. However, current methods for evaluation of middle ear mobility are mostly limited to the surgeon's subjective impression through manual palpation of the ossicles. This study investigates how middle ear transfer function is affected by stapes quasi-static stiffness of the ossicular chain. The stiffness of the middle ear is induced by a) using a novel fiber-optic 3-axis force sensor to quantify the quasi-static stiffness of the middle ear, and b) by artificial reduction of stapes mobility due to drying of the middle ear...
November 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/29098389/symptomatic-os-talus-secundarius-a-case-report-and-review-of-the-literature
#15
Ozkan Kose, Hasan May, Baver Acar, Melih Unal
Os talus secundarius is an extremely rare accessory ossicle located at the lateral aspect of the talus just anterior to the fibula. Although rarely seen, it may cause lateral-sided chronic ankle pain. Only a few cases of symptomatic os talus secundarius have been reported to date. Herein, a 42-year-old male patient with symptomatic os talus secundarius is presented, and its imaging findings, differential diagnosis, and treatment are discussed. LEVEL OF EVIDENCE: Level IV.
November 2, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29089000/ununited-bone-ossicle-in-a-patient-with-patellar-tendinopathy
#16
Emily B Beyer, Elena J Jelsing, Wendy J Hurd
A 40-year-old man presented to a physician for knee pain when squatting and in resisted knee extension. The initial diagnosis was patellar tendinopathy. Following physical therapy treatment, a sports medicine physician was consulted for a second opinion. Radiography, diagnostic ultrasound, and magnetic resonance imaging were performed, confirming the original diagnosis and revealing Hoffa's fat pad impingement secondary to an ununited ossicle. J Orthop Sports Phys Ther 2017;47(11):885. doi:10.2519/jospt.2017...
November 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29068074/the-anterior-process-of-the-malleus-in-extant-lagomorpha-mammalia
#17
Wolfgang Maier, Adrian Tröscher, Irina Ruf
The anterior anchoring of the malleus of 30 extant species of Lagomorpha (rabbits, hares, pikas) has been studied on the basis of histological serial sections and µCT-scans. It is shown that former studies of Oryctolagus, Lepus, and Ochotona are incomplete, because the rostral part of the processus anterior of the malleus is always lacking due to damage of this extremely delicate structure. Our study shows that in perinatal stages of Leporidae the praearticulare develops a prominent processus internus that fits into a groove at the ventral side of the tegmen tympani; this "tongue and groove"-arrangement may act as a hinge...
October 25, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29023005/study-on-carapace-width-growth-band-counts-relationship-of-orange-mud-crab-scylla-olivacea-herbst-1796-from-terengganu-coastal-waters-malaysia
#18
N Hasyima Ismail, A Amin Safwan, N Fairuz Fozi, F H Megat, H Muhd Farouk, S A Kamaruddin, M Ikhwanuddin, M A Ambak
BACKGROUND: Orange mud crab Scylla olivacea is one of the most important fisheries resources. A new development in ageing technique of crustaceans has been introduced. The detection of growth band deposited in hard structure of gastric mill in the cardiac stomach are found retained after moulting process can be used as age indicator and growth estimation. OBJECTIVE: This study was carried out to determine the comparison between carapace width and growth band count of S...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/28989763/into-the-dark-patterns-of-middle-ear-adaptations-in-subterranean-eulipotyphlan-mammals
#19
Daisuke Koyabu, Misato Hosojima, Hideki Endo
Evolution of the middle ear ossicles was a key innovation for mammals, enhancing the transmission of airborne sound. Radiation into various habitats from a terrestrial environment resulted in diversification of the auditory mechanisms among mammals. However, due to the paucity of phylogenetically controlled investigations, how middle ear traits have diversified with functional specialization remains unclear. In order to identify the respective patterns for various lifestyles and to gain insights into fossil forms, we employed a high-resolution tomography technique and compared the middle ear morphology of eulipotyphlan species (moles, shrews and hedgehogs), a group that has radiated into various environments, such as terrestrial, aquatic and subterranean habitats...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28988463/evidence-against-the-mucosal-traction-theory-in-cholesteatoma
#20
Henrique F Pauna, Rafael C Monsanto, Patricia Schachern, Michael M Paparella, Richard A Chole, Sebahattin Cureoglu
OBJECTIVES: To investigate the distribution of ciliated epithelium in the human middle ear and its potential role in the formation of cholesteatoma. STUDY DESIGN: Comparative human temporal bone study. METHODS: We selected temporal bones from 14 donors with a diagnosis of cholesteatoma, 15 with chronic otitis media without retraction pockets, 14 with chronic otitis media with retraction pockets, 14 with cystic fibrosis (CF), and 16 controls...
October 8, 2017: Laryngoscope
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