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https://www.readbyqxmd.com/read/28420248/creating-an-optimal-3d-printed-model-for-temporal-bone-dissection-training
#1
Kuniyuki Takahashi, Yuka Morita, Shinsuke Ohshima, Shuji Izumi, Yamato Kubota, Yutaka Yamamoto, Sugata Takahashi, Arata Horii
OBJECTIVE: Making a 3-dimensional (3D) temporal bone model is simple using a plaster powder bed and an inkjet printer. However, it is difficult to reproduce air-containing spaces and precise middle ear structures. The objective of this study was to overcome these problems and create a temporal bone model that would be useful both as a training tool and for preoperative simulation. METHODS: Drainage holes were made to remove excess materials from air-containing spaces, ossicle ligaments were manually changed to bony structures, and small and/or soft tissue structures were colored differently while designing the 3D models...
April 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28390446/genetic-influence-on-accessory-navicular-bone-in-the-foot-a-korean-twin-and-family-study
#2
In Yae Cheong, Hyo Jeong Kang, Hyeonyoung Ko, Joohon Sung, Yun-Mi Song, Ji Hye Hwang
An accessory navicular bone (AN) is the most common accessory ossicle in the foot. The presence of an AN bone can trigger various foot problems, such as posterior tibial tendon pathology, flattening of the medial longitudinal arch, and medial foot pain. Despite the clinical influence of presence of an AN in foot disease, the research regarding its inheritance is still insufficient. A total of 135 pairs of monozygotic (MZ) twins, 25 pairs of dizygotic (DZ) twins, and 676 singletons from families were enrolled in order to estimate genetic influences on AN...
April 9, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28387614/reduction-of-atlantoaxial-dislocation-prevented-by-pathological-position-of-the-transverse-ligament-in-fixed-irreducible-os-odontoideum-operative-illustrations-and-radiographic-correlates-in-41-patients
#3
Brian J Dlouhy, Bruno A Policeni, Arnold H Menezes
OBJECTIVE Os odontoideum (OO) is a craniovertebral junction (CVJ) abnormality in which an ossicle (small bone) is cranial to a hypoplastic dens by a variable gap. This abnormality can result in instability, which may be reducible or irreducible. What leads to irreducibility in OO is unclear. Therefore, the authors sought to better understand the causes of irreducibility in OO. METHODS A retrospective review was conducted, which identified more than 200 patients who had undergone surgical treatment for OO between 1978 and 2015 at the University of Iowa Hospitals and Clinics...
April 7, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28320600/tympanometry-and-isolated-fracture-of-the-stapes
#4
C Aussedat, C Bobiller, K Gaillot, E Lescanne, D Bakhos
INTRODUCTION: Temporal bone fractures are frequently associated with ossicular dislocations or fractures, most commonly involving the incus. To our knowledge, isolated fracture of the posterior crus of the stapes has not been previously reported. CASE REPORT: A 20-year-old man consulted for persistent left hypoacusis several months after a head injury. Initial computed tomography of the temporal bone showed a simple temporal bone fracture with no other associated abnormalities...
March 17, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28295608/incidence-and-anatomical-variations-of-accessory-navicular-bone-in-patients-with-foot-pain-a-retrospective-radiographic-analysis
#5
Heba Kalbouneh, Omar Alajoulin, Mohammad Alsalem, Noor Humoud, Jamil Shawaqfeh, Mohammad Alkhoujah, Hana Abu-Hassan, Waleed Mahafza, Darwish Badran
The accessory navicular (AN) is an accessory ossicle anatomically located on the medial side of the foot, proximal to the navicular and continuous with the tibialis posterior tendon. It is occasionally a source of pain and local tenderness. Knowledge of the AN and its morphological variations can help identify the source of a patient's symptoms and prevent misinterpreting them as fractures. Foot radiographs from 1,240 patients who presented in two centers with chronic foot pain, or persistent pain developed after trauma, were retrospectively reviewed to determine the incidence and variations of the AN in relation to gender...
March 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28292847/human-umbilical-cord-blood-borne-fibroblasts-contain-marrow-niche-precursors-that-form-a-bone-marrow-organoid-in-vivo
#6
Alice Pievani, Benedetto Sacchetti, Alessandro Corsi, Benedetta Rambaldi, Samantha Donsante, Valeria Scagliotti, Patrizia Vergani, Cristina Remoli, Andrea Biondi, Pamela G Robey, Mara Riminucci, Marta Serafini
Human umbilical cord blood (CB) has attracted much attention as a reservoir for functional hematopoietic stem and progenitor cells, and, recently, as a source of blood-borne fibroblasts (CB-BFs). Previously, we demonstrated that bone marrow stromal cell (BMSC) and CB-BF pellet cultures make cartilage in vitro Furthermore, upon in vivo transplantation, BMSC pellets remodelled into miniature bone/marrow organoids. Using this in vivo model, we asked whether CB-BF populations that express characteristics of the hematopoietic stem cell (HSC) niche contain precursors that reform the niche...
March 15, 2017: Development
https://www.readbyqxmd.com/read/28292001/-implantable-bone-conduction-and-active-middle-ear-devices
#7
Markus Pirlich, Andreas Dietz, Sylvia Meuret, Mathias Hofer
In case of audiological and/or anatomical limitations in the provision of conventional hearing aids, semi- or fully-implantable hearing systems represent a modern therapy alternative. These hearing systems are divided according to their mode of action into active middle ear implants when stimulating the auditory ossicles or the round window, into bone conduction devices while stimulating the skull directly, into cochlear implants with direct acoustic stimulation to the cochlea with its auditory nerve and finally into auditory brainstem implants by bridging the peripheral auditory structures...
February 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28273957/morphological-variations-of-middle-ear-ossicles-and-its-clinical-implications
#8
Ritaban Saha, Phalguni Srimani, Ardhendu Mazumdar, Sibani Mazumdar
INTRODUCTION: The middle ear ossicles form a semi rigid chain in the middle of the ear for conduction and amplification of sound waves from the tympanic membrane to the inner ear. Although, our knowledge of the ear ossicles dates back to the 15(th) century, and various studies have been carried out on their morphometry, morphology, anomalies, embryology, function and structure throughout the world, information about the morphology of middle ear ossicles is meagre in Indian subjects. AIM: To find out the morphological variations of middle ear ossicles of right and left sides...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28255943/posterior-tibial-tendon-impingement-due-to-os-subtibiale-a-case-report-and-up-to-date-review
#9
Adil Turan, Ozkan Kose, Baver Acar, Melih Unal
Os subtibiale is a rare accessory ossicle located at the tip of the medial malleolus. Although this small ossicle usually has no clinical significance, in some cases it may be a source of ankle pain. Symptomatic os subtibiale is an extremely rare diagnosis, and few cases have been reported to date. The case presented is of a 35-year-old female patient with symptomatic os subtibiale, with a discussion of the diagnosis, clinical findings, and treatment options.
March 2, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28255483/stenosing-tenosynovitis-of-the-flexor-hallucis-longus-tendon-associated-with-the-plantar-capsular-accessory-ossicle-at-the-interphalangeal-joint-of-the-great-toe
#10
Song Ho Chang, Takumi Matsumoto, Masashi Naito, Sakae Tanaka
This report presents a case of stenosing tenosynovitis of the flexor hallucis longus tendon associated with the plantar capsular accessory ossicle at the interphalangeal joint of the great toe, which was confirmed by intraoperative observation and was successfully treated with surgical resection of the ossicle. As the plantar capsular accessory ossicle was not visible radiographically due to the lack of ossification, ultrasonography was helpful for diagnosing this disorder.
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28196691/healing-of-a-large-long-bone-defect-through-serum-free-in%C3%A2-vitro-priming-of%C3%A2-human-periosteum-derived-cells
#11
Johanna Bolander, Wei Ji, Jeroen Leijten, Liliana Moreira Teixeira, Veerle Bloemen, Dennis Lambrechts, Malay Chaklader, Frank P Luyten
Clinical translation of cell-based strategies for regenerative medicine demands predictable in vivo performance where the use of sera during in vitro preparation inherently limits the efficacy and reproducibility. Here, we present a bioinspired approach by serum-free pre-conditioning of human periosteum-derived cells, followed by their assembly into microaggregates simultaneously primed with bone morphogenetic protein 2 (BMP-2). Pre-conditioning resulted in a more potent progenitor cell population, while aggregation induced osteochondrogenic differentiation, further enhanced by BMP-2 stimulation...
March 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28187565/a-taxonomic-review-of-the-genus-astrohelix-d%C3%A3-derlein-1930-including-the%C3%A2-synonymy-of-the-subgenus-i-asteroporpa-i-i-astromoana-i-baker-1980-to-i-astrohelix-i
#12
Masanori Okanishi
The holotypes of Astrohelix bellator bellator and Astrohelix bellator paucidens (Echinodermata: Ophiuroidea: Euryalida: Gorgonocephalidae) are redescribed. Based on these observations Asteroporpa (Astromoana) with Astrohelix is proposed. With the elevation of two subspecies of Asteroporpa (Astrohelix) bellator bellator and A. (Astrohelix) bellator paucidens to species level, A. (Astrohelix) comprises six species, A. (Astrohelix) bellator, A. (Astrohelix) indicus, A. (Astrohelix) koyoae, A. (Astrohelix) muricatopatella, A...
February 6, 2017: Zootaxa
https://www.readbyqxmd.com/read/28182695/two-three-loci-control-scleral-ossicle-formation-via-epistasis-in-the-cavefish-astyanax-mexicanus
#13
Anastasia Lyon, Amanda K Powers, Joshua B Gross, Kelly E O'Quin
The sclera is the protective outer layer of the eye. In fishes, birds, and reptiles, the sclera may be reinforced with additional bony elements called scleral ossicles. Teleost fish vary in the number and size of scleral ossicles; however, the genetic mechanisms responsible for this variation remain poorly understood. In this study, we examine the inheritance of scleral ossicles in the Mexican tetra, Astyanax mexicanus, which exhibits both a cave morph and a surface fish morph. As these morphs and their hybrids collectively exhibit zero, one, and two scleral ossicles, they represent a microcosm of teleost scleral ossicle diversity...
2017: PloS One
https://www.readbyqxmd.com/read/28179517/a-new-developmental-mechanism-for-the-separation-of-the-mammalian-middle-ear-ossicles-from-the-jaw
#14
Daniel J Urban, Neal Anthwal, Zhe-Xi Luo, Jennifer A Maier, Alexa Sadier, Abigail S Tucker, Karen E Sears
Multiple mammalian lineages independently evolved a definitive mammalian middle ear (DMME) through breakdown of Meckel's cartilage (MC). However, the cellular and molecular drivers of this evolutionary transition remain unknown for most mammal groups. Here, we identify such drivers in the living marsupial opossum Monodelphis domestica, whose MC transformation during development anatomically mirrors the evolutionary transformation observed in fossils. Specifically, we link increases in cellular apoptosis and TGF-BR2 signalling to MC breakdown in opossums...
February 8, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28171738/analysis-of-audiometric-outcomes-following-combined-middle-cranial-fossa-transmastoid-approaches-for-spontaneous-cerebrospinal-fluid-otorrhea
#15
Shawn M Stevens, Ryan Crane, Myles L Pensak, Ravi N Samy
Outcome Objectives To (1) explore audiometric outcomes following use of a combined transmastoid/middle cranial fossa (TM-MCF) approach in the treatment of spontaneous cerebrospinal fluid (CSF) otorrhea and (2) determine the influence of dehiscence location and reconstructive methodology on audiometric outcomes. Study Design Case series with chart review. Setting Tertiary care center. Subjects and Methods Adults with spontaneous CSF otorrhea were reviewed from 2007 to 2016 if they underwent combined TM-MCF. Definitive audiometric evaluations were performed at least 3 months postoperatively...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28169040/os-subtibiale-mimicking-medial-malleolar-fracture-a-report-of-three-cases-and-review-of-literature
#16
Murat Topal, Ahmet Köse, Recep Dinçer, Tuncay Baran, Mehmet Köse, M Çağatay Engin
There are numerous sesamoids and accessory ossicles around the foot which can easily be misdiagnosed as fractures. Os subtibiale is a very rare normal variant of the medial malleolus which is usually diagnosed incidentally in routine ankle radiographs. In this report, we present a case series of 3 patients with os subtibiale who were admitted to the emergency department with ankle sprains and misdiagnosed as medial malleolar fractures. We would like to raise awareness to the very rare and usually asymptomatic os subtibiale as a diagnostic pitfall...
December 31, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28152584/a-wide-temporal-window-for-conjunctival-papillae-development-ensures-the-formation-of-a-complete-sclerotic-ring
#17
Karyn Jourdeuil, Tamara Anne Franz-Odendaal
BACKGROUND: The conjunctival papillae are epithelial thickenings of the conjunctiva that are required for the induction of underlying bones (the scleral ossicles). These transient papillae develop and become inductively active over an extended temporal period (HH 30-36, 6.5-10 dpf). While their inductive capacity was discovered in the mid-1900s, little is known about their development. RESULTS: Through a series of timed surgical ablations followed by in situ hybridization for Bmp2, we show that the ring of conjunctival papillae is not altered if the conjunctival epithelium is ablated either prior to or shortly after papillae induction (i...
February 2, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28149724/endoscopic-accessory-navicular-synchondrosis-fusion
#18
Tun Hing Lui
The accessory navicular bone is one of the most common accessory ossicles of the foot. Fewer than 1% of accessory navicular bones are symptomatic, and most of these are type II accessory navicular bones. A separation of the synchondrosis is considered one of the main causes of pain. After an injury to the synchondrosis has resulted in a chondro-osseous disruption, the combined forces of tension and shear from the posterior tibial tendon and the foot aggravate the injury and prevent it from healing. Fusion of the synchondrosis is a logical surgical treatment option if the pain is recalcitrant to conservative measures...
December 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28119792/characterization-and-epidemiology-of-the-carpal-boss-utilizing-computed-tomography
#19
Christopher Goiney, Jack Porrino, Michael L Richardson, Hyojeong Mulcahy, Felix S Chew
Background The carpal boss is an osseous protuberance occurring variably along the dorsum of the second or third metacarpal base, lacking a standardized definition. Aim We sought to characterize the dorsal second and third carpometacarpal joints in the general population on computed tomography (CT) to better define this variant anatomy. Patients and Methods A total of 129 wrist CT studies were reviewed. Note was made of the dorsal second/third carpometacarpal osseous anatomy, the presence of regional bursitis or tenosynovitis, and relationship of the extensor carpi radialis brevis attachment to the base of the third metacarpal...
February 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28117786/dissection-of-the-auditory-bulla-in-postnatal-mice-isolation-of-the-middle-ear-bones-and-histological-analysis
#20
Ayako Sakamoto, Yukiko Kuroda, Sho Kanzaki, Koichi Matsuo
In most mammals, auditory ossicles in the middle ear, including the malleus, incus and stapes, are the smallest bones. In mice, a bony structure called the auditory bulla houses the ossicles, whereas the auditory capsule encloses the inner ear, namely the cochlea and semicircular canals. Murine ossicles are essential for hearing and thus of great interest to researchers in the field of otolaryngology, but their metabolism, development, and evolution are highly relevant to other fields. Altered bone metabolism can affect hearing function in adult mice, and various gene-deficient mice show changes in morphogenesis of auditory ossicles in utero...
January 4, 2017: Journal of Visualized Experiments: JoVE
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