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https://www.readbyqxmd.com/read/28196691/healing-of-a-large-long-bone-defect-through-serum-free-in%C3%A2-vitro-priming-of%C3%A2-human-periosteum-derived-cells
#1
Johanna Bolander, Wei Ji, Jeroen Leijten, Liliana Moreira Teixeira, Veerle Bloemen, Dennis Lambrechts, Malay Chaklader, Frank P Luyten
Clinical translation of cell-based strategies for regenerative medicine demands predictable in vivo performance where the use of sera during in vitro preparation inherently limits the efficacy and reproducibility. Here, we present a bioinspired approach by serum-free pre-conditioning of human periosteum-derived cells, followed by their assembly into microaggregates simultaneously primed with bone morphogenetic protein 2 (BMP-2). Pre-conditioning resulted in a more potent progenitor cell population, while aggregation induced osteochondrogenic differentiation, further enhanced by BMP-2 stimulation...
February 7, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28187565/a-taxonomic-review-of-the-genus-astrohelix-d%C3%A3-derlein-1930-including-the%C3%A2-synonymy-of-the-subgenus-i-asteroporpa-i-i-astromoana-i-baker-1980-to-i-astrohelix-i
#2
Masanori Okanishi
The holotypes of Astrohelix bellator bellator and Astrohelix bellator paucidens (Echinodermata: Ophiuroidea: Euryalida: Gorgonocephalidae) are redescribed. Based on these observations Asteroporpa (Astromoana) with Astrohelix is proposed. With the elevation of two subspecies of Asteroporpa (Astrohelix) bellator bellator and A. (Astrohelix) bellator paucidens to species level, A. (Astrohelix) comprises six species, A. (Astrohelix) bellator, A. (Astrohelix) indicus, A. (Astrohelix) koyoae, A. (Astrohelix) muricatopatella, A...
February 6, 2017: Zootaxa
https://www.readbyqxmd.com/read/28182695/two-three-loci-control-scleral-ossicle-formation-via-epistasis-in-the-cavefish-astyanax-mexicanus
#3
Anastasia Lyon, Amanda K Powers, Joshua B Gross, Kelly E O'Quin
The sclera is the protective outer layer of the eye. In fishes, birds, and reptiles, the sclera may be reinforced with additional bony elements called scleral ossicles. Teleost fish vary in the number and size of scleral ossicles; however, the genetic mechanisms responsible for this variation remain poorly understood. In this study, we examine the inheritance of scleral ossicles in the Mexican tetra, Astyanax mexicanus, which exhibits both a cave morph and a surface fish morph. As these morphs and their hybrids collectively exhibit zero, one, and two scleral ossicles, they represent a microcosm of teleost scleral ossicle diversity...
2017: PloS One
https://www.readbyqxmd.com/read/28179517/a-new-developmental-mechanism-for-the-separation-of-the-mammalian-middle-ear-ossicles-from-the-jaw
#4
Daniel J Urban, Neal Anthwal, Zhe-Xi Luo, Jennifer A Maier, Alexa Sadier, Abigail S Tucker, Karen E Sears
Multiple mammalian lineages independently evolved a definitive mammalian middle ear (DMME) through breakdown of Meckel's cartilage (MC). However, the cellular and molecular drivers of this evolutionary transition remain unknown for most mammal groups. Here, we identify such drivers in the living marsupial opossum Monodelphis domestica, whose MC transformation during development anatomically mirrors the evolutionary transformation observed in fossils. Specifically, we link increases in cellular apoptosis and TGF-BR2 signalling to MC breakdown in opossums...
February 8, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28171738/analysis-of-audiometric-outcomes-following-combined-middle-cranial-fossa-transmastoid-approaches-for-spontaneous-cerebrospinal-fluid-otorrhea
#5
Shawn M Stevens, Ryan Crane, Myles L Pensak, Ravi N Samy
Outcome Objectives To (1) explore audiometric outcomes following use of a combined transmastoid/middle cranial fossa (TM-MCF) approach in the treatment of spontaneous cerebrospinal fluid (CSF) otorrhea and (2) determine the influence of dehiscence location and reconstructive methodology on audiometric outcomes. Study Design Case series with chart review. Setting Tertiary care center. Subjects and Methods Adults with spontaneous CSF otorrhea were reviewed from 2007 to 2016 if they underwent combined TM-MCF. Definitive audiometric evaluations were performed at least 3 months postoperatively...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28169040/os-subtibiale-mimicking-medial-malleolar-fracture-a-report-of-three-cases-and-review-of-literature
#6
Murat Topal, Ahmet Köse, Recep Dinçer, Tuncay Baran, Mehmet Köse, M Çağatay Engin
There are numerous sesamoids and accessory ossicles around the foot which can easily be misdiagnosed as fractures. Os subtibiale is a very rare normal variant of the medial malleolus which is usually diagnosed incidentally in routine ankle radiographs. In this report, we present a case series of 3 patients with os subtibiale who were admitted to the emergency department with ankle sprains and misdiagnosed as medial malleolar fractures. We would like to raise awareness to the very rare and usually asymptomatic os subtibiale as a diagnostic pitfall...
December 31, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28152584/a-wide-temporal-window-for-conjunctival-papillae-development-ensures-the-formation-of-a-complete-sclerotic-ring
#7
Karyn Jourdeuil, Tamara Anne Franz-Odendaal
BACKGROUND: The conjunctival papillae are epithelial thickenings of the conjunctiva that are required for the induction of underlying bones (the scleral ossicles). These transient papillae develop and become inductively active over an extended temporal period (HH 30-36, 6.5-10 dpf). While their inductive capacity was discovered in the mid-1900s, little is known about their development. RESULTS: Through a series of timed surgical ablations followed by in situ hybridization for Bmp2, we show that the ring of conjunctival papillae is not altered if the conjunctival epithelium is ablated either prior to or shortly after papillae induction (i...
February 2, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28149724/endoscopic-accessory-navicular-synchondrosis-fusion
#8
Tun Hing Lui
The accessory navicular bone is one of the most common accessory ossicles of the foot. Fewer than 1% of accessory navicular bones are symptomatic, and most of these are type II accessory navicular bones. A separation of the synchondrosis is considered one of the main causes of pain. After an injury to the synchondrosis has resulted in a chondro-osseous disruption, the combined forces of tension and shear from the posterior tibial tendon and the foot aggravate the injury and prevent it from healing. Fusion of the synchondrosis is a logical surgical treatment option if the pain is recalcitrant to conservative measures...
December 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28119792/characterization-and-epidemiology-of-the-carpal-boss-utilizing-computed-tomography
#9
Christopher Goiney, Jack Porrino, Michael L Richardson, Hyojeong Mulcahy, Felix S Chew
Background The carpal boss is an osseous protuberance occurring variably along the dorsum of the second or third metacarpal base, lacking a standardized definition. Aim We sought to characterize the dorsal second and third carpometacarpal joints in the general population on computed tomography (CT) to better define this variant anatomy. Patients and Methods A total of 129 wrist CT studies were reviewed. Note was made of the dorsal second/third carpometacarpal osseous anatomy, the presence of regional bursitis or tenosynovitis, and relationship of the extensor carpi radialis brevis attachment to the base of the third metacarpal...
February 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28117786/dissection-of-the-auditory-bulla-in-postnatal-mice-isolation-of-the-middle-ear-bones-and-histological-analysis
#10
Ayako Sakamoto, Yukiko Kuroda, Sho Kanzaki, Koichi Matsuo
In most mammals, auditory ossicles in the middle ear, including the malleus, incus and stapes, are the smallest bones. In mice, a bony structure called the auditory bulla houses the ossicles, whereas the auditory capsule encloses the inner ear, namely the cochlea and semicircular canals. Murine ossicles are essential for hearing and thus of great interest to researchers in the field of otolaryngology, but their metabolism, development, and evolution are highly relevant to other fields. Altered bone metabolism can affect hearing function in adult mice, and various gene-deficient mice show changes in morphogenesis of auditory ossicles in utero...
January 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28050207/is-there-a-system%C3%A4-c-inflammatory-effect-of-cholesteatoma
#11
M Mustafa Kılıçkaya, Giray Aynali, Mustafa Tuz, Özkan Bagcı
Introduction Inflammation causes squamous epithelial transformation of the mucosa in the middle ear cavity and plays a role in the onset, growth, spread, and recurrence of cholesteatoma. Objectives The objective of this study is to investigate the systemic inflammatory effect in chronic otitis with cholesteatoma. Methods The study included a total of 311 patients comprising 156 patients with a pathology diagnosis of cholesteatoma and a control group of 155 with no active inflammation. The Neutrophil-to-lymphocyte Ratio (NLR) was calculated by dividing the neutrophil value by the lymphocyte value...
January 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/27999926/results-of-arthroscopic-treatment-in-unresolved-osgood-schlatter-disease-in-athletes
#12
Esra Circi, Tahsin Beyzadeoglu
AIM OF THE STUDY: In this study we aimed to determine outcomes following arthroscopic ossicle excision in athletes with unresolved Osgood-Schlatter disease (OSD). METHOD: Arthroscopy was performed on 11 patients (11 knees) with OSD between September 2008 and November 2014. Surgical treatment inclusion criteria were determined as: failure of conservative treatment; isolated pain over the tibial tubercle and distal patellar tendon; pain limiting sporting performance at a competitive level...
December 21, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27994124/major-evolutionary-transitions-and-innovations-the-tympanic-middle-ear
#13
REVIEW
Abigail S Tucker
One of the most amazing transitions and innovations during the evolution of mammals was the formation of a novel jaw joint and the incorporation of the original jaw joint into the middle ear to create the unique mammalian three bone/ossicle ear. In this review, we look at the key steps that led to this change and other unusual features of the middle ear and how developmental biology has been providing an understanding of the mechanisms involved. This starts with an overview of the tympanic (air-filled) middle ear, and how the ear drum (tympanic membrane) and the cavity itself form during development in amniotes...
February 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27988762/a-new-genus-and-a-new-species-in-the-sea-cucumber-subfamily-colochirinae-echinodermata-holothuroidea-dendrochirotida-cucumariidae-in-the-mediterranean-sea
#14
Sifiso Mjobo, Ahmed S Thandar
A new genus Hemiocnus is here erected to accommodate the Mediterranean dendrochirotid sea cucumber Cladodactyla syracusana Grube, currently classified, with some doubt, in the cucumariid genus Pseudocnella. At the same time a new cucumariid species, Hemiocnus rubrobrunneus, is described from some Tunisian material, misidentified as Pseudocnella syracusana (Grube), received from the United States National Museum. The new genus appears most closely related to Pseudocnella than to any other genus within the Colochirinae...
November 9, 2016: Zootaxa
https://www.readbyqxmd.com/read/27984063/off-axis-astigmatism-in-the-isolated-chicken-crystalline-lens
#15
Felix Maier, Siegfried Wahl, Frank Schaeffel
The chicken eye was previously found to have little off-axis astigmatism which is not explained by its special corneal shape but rather by the optical properties of the crystalline lens. To learn more about lens design, we studied off-axis astigmatism in the chicken lens in situ and compared it to a glass lens of similar power but with homogenous refractive index. After euthanasia, enucleated eye balls were cut in the equatorial plane right behind the scleral ossicles. The anterior segment was placed in a water-filled chamber...
October 28, 2016: Vision Research
https://www.readbyqxmd.com/read/27923771/off-axis-astigmatism-in-the-isolated-chicken-crystalline-lens
#16
Felix Maier, Siegfried Wahl, Frank Schaeffel
The chicken eye was previously found to have little off-axis astigmatism which is not explained by its special corneal shape but rather by the optical properties of the crystalline lens. To learn more about lens design, we studied off-axis astigmatism in the chicken lens in situ and compared it to a glass lens of similar power but with homogenous refractive index. After euthanasia, enucleated eye balls were cut in the equatorial plane right behind the scleral ossicles. The anterior segment was placed in a water-filled chamber...
December 2016: Vision Research
https://www.readbyqxmd.com/read/27896803/the-effect-of-craniokinesis-on-the-middle-ear-of-domestic-chickens-gallus-gallus-domesticus
#17
Raf Claes, Pieter G G Muyshondt, Luc Van Hoorebeke, Jelle Dhaene, Joris J J Dirckx, Peter Aerts
The avian middle ear differs from that of mammalians and contains a tympanic membrane, one ossicle (bony columella and cartilaginous extra-columella), some ligaments and one muscle. The rim of the eardrum (closing the middle ear cavity) is connected to the neurocranium and, by means of a broad ligament, to the otic process of the quadrate. Due to the limited number of components in the avian middle ear, the possibilities of attenuating the conduction of sound seem to be limited to activity of the stapedius muscle...
November 29, 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27833874/effect-of-type-1-tympanoplasty-on-the-quality-of-life-of-csom-patients
#18
Khyati Bhatia, Lakshmi Vaid, H C Taneja
Chronic suppurative otitis media (CSOM) continues to be an important public health problem despite significant advances in medical science. Ear discharge, pain, discomfort, difficulty in hearing, limitation of routine activities and emotional problems due to CSOM cause a significant impact on the health and general well being of the patient. We have done Type 1 tympanoplasty in tubotympanic type of COM to reconstruct the tympanic membrane and alleviate the symptoms of the patients. This study presents an analysis of the impact of the surgery on the patient subjectively and its correlation with objective outcomes...
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27809939/electrocoagulation-improving-bone-cement-use-in-middle-ear-surgery-short-term-and-middle-term-results
#19
C Galy-Bernadoy, M Akkari, M Mondain, A Uziel, F Venail
BACKGROUND: Bone cement is used for ossicular chain repair and revision stapes surgery. Its efficient use requires cautious removal of mucosa from the ossicles. This paper reports a technique for easy, fast and safe removal of this mucosa prior to cement application. It consists of the application of monopolar electrocoagulation on the ossicles prior to bone cement application. METHODS: The outcomes of six cases of revision stapes surgery and seven cases of partial ossiculoplasty, conducted between 2007 and 2012 using this new technique, were evaluated...
December 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27807249/singing-whales-generate-high-levels-of-particle-motion-implications-for-acoustic-communication-and-hearing
#20
T Aran Mooney, Maxwell B Kaplan, Marc O Lammers
Acoustic signals are fundamental to animal communication, and cetaceans are often considered bioacoustic specialists. Nearly all studies of their acoustic communication focus on sound pressure measurements, overlooking the particle motion components of their communication signals. Here we characterized the levels of acoustic particle velocity (and pressure) of song produced by humpback whales. We demonstrate that whales generate acoustic fields that include significant particle velocity components that are detectable over relatively long distances sufficient to play a role in acoustic communication...
November 2016: Biology Letters
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