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https://www.readbyqxmd.com/read/29452236/cardiac-and-placental-mitochondrial-characterization-in-a-rabbit-model-of-intrauterine-growth-restriction
#1
M Guitart-Mampel, A Gonzalez-Tendero, S Niñerola, C Morén, M Catalán-Garcia, I González-Casacuberta, D L Juárez-Flores, O Ugarteburu, L Matalonga, M V Cascajo, F Tort, A Cortés, E Tobias, J C Milisenda, J M Grau, F Crispi, E Gratacós, G Garrabou, F Cardellach
BACKGROUND: Intrauterine growth restriction (IUGR) is associated with cardiovascular remodeling persisting into adulthood. Mitochondrial bioenergetics, essential for embryonic development and cardiovascular function, are regulated by nuclear effectors as sirtuins. A rabbit model of IUGR and cardiovascular remodeling was generated, in which heart mitochondrial alterations were observed by microscopic and transcriptomic analysis. We aimed to evaluate if such alterations are translated at a functional mitochondrial level to establish the etiopathology and potential therapeutic targets for this obstetric complication...
February 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29452212/exploring-in-vivo-metabolism-and-excretion-of-qo-58l-using-ultra-high-performance-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#2
Jiaqi Zhang, Qingzhong Jia, Jinlong Qi, Hailin Zhang, Yaru Wu, Xiaowei Shi
QO-58 lysine (QO-58L) as a new potassium channel opener, reported to have a potential activity to cure neuropathic pain. The aim of this research is to develop and validate a high-performance liquid chromatography with tandem spectrometry (LC-MS/MS) method for the quantification of QO-58L in rat urine, feces and bile. In addition, analyze and identify the metabolites in urine and bile. The assay for this compound in samples detected with multiple reaction monitoring mode (MRM), and take nimodipine as internal standards (IS)...
February 13, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29448359/simple-analysis-of-scattering-data-with-the-ornstein-zernike-equation
#3
E I Kats, A R Muratov
In this paper we propose and explore a method of analysis of the scattering experimental data for uniform liquidlike systems. In our pragmatic approach we are not trying to introduce by hands an artificial small parameter to work out a perturbation theory with respect to the known results, e.g., for hard spheres or sticky hard spheres (all the more that in the agreement with the notorious Landau statement, there is no physical small parameter for liquids). Instead of it being guided by the experimental data we are solving the Ornstein-Zernike equation with a trial (variational) form of the interparticle interaction potential...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29447424/experimental-and-theoretical-identification-of-the-origin-of-magnetic-anisotropy-in-intermediate-spin-ground-state-iron-iii-complexes
#4
Lianke Wang, Matija Zlatar, Filip Vlahovic, Serhiy Demeshko, Christian Philouze, Florian Molton, Franc Meyer, Carole Duboc, Maja Gruden, Marcello Gennari
The complexes [FeLN2S2X] (where LN2S2 = 2,2'-(2,2'-bipryridine-6,6'-diyl)bis(1,1'-diphenylethanethiolate) and X = Cl, Br and I), characterized crystallographically earlier and here (Fe(L)Br), reveal a square pyramidal coordinated FeIII ion. Unusually, all three complexes have intermediate spin ground states. Susceptibility measurements, powder cw X- and Q-band EPR spectra, zero-field powder Mössbauer spectra and DFT calculations show that all complexes display distinct magnetic anisotropy.
February 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29446773/an-experimental-toolbox-for-characterization-of-mammalian-collagen-type-i-in-biological-specimens
#5
Héctor Capella-Monsonís, João Q Coentro, Valeria Graceffa, Zhuning Wu, Dimitrios I Zeugolis
Collagen type I is the most abundant extracellular matrix protein, and collagen type I supramolecular assemblies (e.g., tissue grafts, biomaterials and cell-assembled systems) are used extensively in tissue engineering and regenerative medicine. Many studies, for convenience or economic reasons, do not accurately determine collagen type I purity, concentration, solubility and extent of cross-linking in biological specimens, frequently resulting in erroneous conclusions. In this protocol, we describe solubility; normal, reduced and delayed (interrupted) SDS-PAGE; hydroxyproline; Sircol collagen and Pierce BCA protein; denaturation temperature; ninhydrin/trinitrobenzene sulfonic acid; and collagenase assays and assess them in a diverse range of biological samples (e...
March 2018: Nature Protocols
https://www.readbyqxmd.com/read/29446313/digital-chalk-talk-videos-improve-knowledge-and-satisfaction-in-renal-physiology
#6
John K Roberts, Saumil M Chudgar, Deborah Engle, Elizabeth K McClain, Emma Jakoi, Michael Berkoben, Ruediger W Lehrich
The authors began a curriculum reform project to improve the experience in a Renal Physiology course for first-year medical students. Taking into account both the variety of learning preferences among students and the benefits of student autonomy, the authors hypothesized that adding digital chalk-talk videos to lecture notes and live lectures would improve student knowledge, course satisfaction, and engagement. The authors measured performance on the renal physiology exam before (the traditional curriculum) and for 2 yr after implementation of the new curriculum...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29446192/increasing-the-autotrophic-growth-of-chlorella-ustb-01-via-the-control-of-bacterial-contamination-by-bdellovibrio-ustb-06
#7
Y Li, F Qiu, H Yan, X Wan, M Wang, K Ren, Q Xu, L Lv, C Yin, X Liu, H Zhang, K Mahmoud
AIMS: (i) To obtain and identify the predatory bacteria for the control of contaminated bacteria and to promote the autotrophic growth of Chlorella USTB-01. (ii) To identify and measure the different cell numbers in microalgal culture using flow cytometer. METHODS AND RESULTS: A predatory bacterial strain was isolated using Escherichia coli BL21 as a sole prey host, which was identified as Bdellovibrio USTB-06 by the analysis of 16S rDNA sequence. A flow cytometer was successfully used to identify and measure the cell numbers of Chlorella USTB-01, the contaminated bacteria and Bdellovibrio USTB-06 simultaneously in the autotrophic culture of Chlorella USTB-01 according to the identification of the different cell sizes...
February 14, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29446161/advancements-and-challenges-in-multidomain-multicargo-delivery-vehicles
#8
REVIEW
Eugenia Pugliese, João Q Coentro, Dimitrios I Zeugolis
Reparative and regenerative processes are well-orchestrated temporal and spatial events that are governed by multiple cells, molecules, signaling pathways, and interactions thereof. Yet again, currently available implantable devices fail largely to recapitulate nature's complexity and sophistication in this regard. Herein, success stories and challenges in the field of layer-by-layer, composite, self-assembly, and core-shell technologies are discussed for the development of multidomain/multicargo delivery vehicles...
February 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29444607/psychometric-evaluation-of-persian-nomophobia-questionnaire-differential-item-functioning-and-measurement-invariance-across-gender
#9
Chung-Ying Lin, Mark D Griffiths, Amir H Pakpour
Background and aims Research examining problematic mobile phone use has increased markedly over the past 5 years and has been related to "no mobile phone phobia" (so-called nomophobia). The 20-item Nomophobia Questionnaire (NMP-Q) is the only instrument that assesses nomophobia with an underlying theoretical structure and robust psychometric testing. This study aimed to confirm the construct validity of the Persian NMP-Q using Rasch and confirmatory factor analysis (CFA) models. Methods After ensuring the linguistic validity, Rasch models were used to examine the unidimensionality of each Persian NMP-Q factor among 3,216 Iranian adolescents and CFAs were used to confirm its four-factor structure...
February 15, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29441027/pragmatically-framed-cross-situational-noun-learning-using-computational-reinforcement-models
#10
Shamima Najnin, Bonny Banerjee
Cross-situational learning and social pragmatic theories are prominent mechanisms for learning word meanings (i.e., word-object pairs). In this paper, the role of reinforcement is investigated for early word-learning by an artificial agent. When exposed to a group of speakers, the agent comes to understand an initial set of vocabulary items belonging to the language used by the group. Both cross-situational learning and social pragmatic theory are taken into account. As social cues, joint attention and prosodic cues in caregiver's speech are considered...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29440738/advantages-of-non-cryopreserved-autologous-hematopoietic-stem-cell-transplantation-against-a-cryopreserved-strategy
#11
M Sarmiento, P Ramírez, R Parody, M Q Salas, N Beffermann, V Jara, P Bertín, I Pizarro, C Lorca, E Rivera, M Galleguillos, M Ocqueteau, I Sánchez-Ortega, B Patiño, A Sureda
Autologous stem cell transplantation (auto-HSCT) is an effective treatment strategy for hematological malignancies. The standard mode of handling hematopoietic progenitors for the autologous procedure (CRYO) consists on its collection and freezing with dimethyl sulfoxide (DMSO) and its subsequent thawing and re-infusion. This process is toxic and expensive. Non-cryopreserved (non-CRYO) is a less expensive mode of auto-HSCT. We designed a comparative study between both strategies performed in two different centers to analyze the short-term complications...
February 13, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29437406/combined-forward-backward-asymmetry-measurements-in-top-antitop-quark-production-at-the-tevatron
#12
T Aaltonen, V M Abazov, B Abbott, B S Acharya, M Adams, T Adams, J P Agnew, G D Alexeev, G Alkhazov, A Alton, S Amerio, D Amidei, A Anastassov, A Annovi, J Antos, G Apollinari, J A Appel, T Arisawa, A Artikov, J Asaadi, W Ashmanskas, A Askew, S Atkins, B Auerbach, K Augsten, A Aurisano, V Aushev, Y Aushev, C Avila, F Azfar, F Badaud, W Badgett, T Bae, L Bagby, B Baldin, D V Bandurin, S Banerjee, A Barbaro-Galtieri, E Barberis, P Baringer, V E Barnes, B A Barnett, P Barria, J F Bartlett, P Bartos, U Bassler, M Bauce, V Bazterra, A Bean, F Bedeschi, M Begalli, S Behari, L Bellantoni, G Bellettini, J Bellinger, D Benjamin, A Beretvas, S B Beri, G Bernardi, R Bernhard, I Bertram, M Besançon, R Beuselinck, P C Bhat, S Bhatia, V Bhatnagar, A Bhatti, K R Bland, G Blazey, S Blessing, K Bloom, B Blumenfeld, A Bocci, A Bodek, A Boehnlein, D Boline, E E Boos, G Borissov, D Bortoletto, M Borysova, J Boudreau, A Boveia, A Brandt, O Brandt, L Brigliadori, M Brochmann, R Brock, C Bromberg, A Bross, D Brown, E Brucken, X B Bu, J Budagov, H S Budd, M Buehler, V Buescher, V Bunichev, S Burdin, K Burkett, G Busetto, P Bussey, C P Buszello, P Butti, A Buzatu, A Calamba, E Camacho-Pérez, S Camarda, M Campanelli, F Canelli, B Carls, D Carlsmith, R Carosi, S Carrillo, B Casal, M Casarsa, B C K Casey, H Castilla-Valdez, A Castro, P Catastini, S Caughron, D Cauz, V Cavaliere, A Cerri, L Cerrito, S Chakrabarti, K M Chan, A Chandra, A Chapelain, E Chapon, G Chen, Y C Chen, M Chertok, G Chiarelli, G Chlachidze, K Cho, S W Cho, S Choi, D Chokheli, B Choudhary, S Cihangir, D Claes, A Clark, C Clarke, J Clutter, M E Convery, J Conway, M Cooke, W E Cooper, M Corbo, M Corcoran, M Cordelli, F Couderc, M-C Cousinou, C A Cox, D J Cox, M Cremonesi, D Cruz, J Cuevas, R Culbertson, J Cuth, D Cutts, A Das, N d'Ascenzo, M Datta, G Davies, P de Barbaro, S J de Jong, E De La Cruz-Burelo, F Déliot, R Demina, L Demortier, M Deninno, D Denisov, S P Denisov, M D'Errico, S Desai, C Deterre, K DeVaughan, F Devoto, A Di Canto, B Di Ruzza, H T Diehl, M Diesburg, P F Ding, J R Dittmann, A Dominguez, S Donati, M D'Onofrio, M Dorigo, A Driutti, A Drutskoy, A Dubey, L V Dudko, A Duperrin, S Dutt, M Eads, K Ebina, R Edgar, D Edmunds, A Elagin, J Ellison, V D Elvira, Y Enari, R Erbacher, S Errede, B Esham, H Evans, A Evdokimov, V N Evdokimov, S Farrington, A Fauré, L Feng, T Ferbel, J P Fernández Ramos, F Fiedler, R Field, F Filthaut, W Fisher, H E Fisk, G Flanagan, R Forrest, M Fortner, H Fox, J Franc, M Franklin, J C Freeman, H Frisch, S Fuess, Y Funakoshi, C Galloni, P H Garbincius, A Garcia-Bellido, J A García-González, A F Garfinkel, P Garosi, V Gavrilov, W Geng, C E Gerber, H Gerberich, E Gerchtein, Y Gershtein, S Giagu, V Giakoumopoulou, K Gibson, C M Ginsburg, G Ginther, N Giokaris, P Giromini, V Glagolev, D Glenzinski, O Gogota, M Gold, D Goldin, A Golossanov, G Golovanov, G Gomez, G Gomez-Ceballos, M Goncharov, O González López, I Gorelov, A T Goshaw, K Goulianos, E Gramellini, P D Grannis, S Greder, H Greenlee, G Grenier, Ph Gris, J-F Grivaz, A Grohsjean, C Grosso-Pilcher, S Grünendahl, M W Grünewald, T Guillemin, J Guimaraes da Costa, G Gutierrez, P Gutierrez, S R Hahn, J Haley, J Y Han, L Han, F Happacher, K Hara, K Harder, M Hare, A Harel, R F Harr, T Harrington-Taber, K Hatakeyama, J M Hauptman, C Hays, J Hays, T Head, T Hebbeker, D Hedin, H Hegab, J Heinrich, A P Heinson, U Heintz, C Hensel, I Heredia-De La Cruz, M Herndon, K Herner, G Hesketh, M D Hildreth, R Hirosky, T Hoang, J D Hobbs, A Hocker, B Hoeneisen, J Hogan, M Hohlfeld, J L Holzbauer, Z Hong, W Hopkins, S Hou, I Howley, Z Hubacek, R E Hughes, U Husemann, M Hussein, J Huston, V Hynek, I Iashvili, Y Ilchenko, R Illingworth, G Introzzi, M Iori, A S Ito, A Ivanov, S Jabeen, M Jaffré, E James, D Jang, A Jayasinghe, B Jayatilaka, E J Jeon, M S Jeong, R Jesik, P Jiang, S Jindariani, K Johns, E Johnson, M Johnson, A Jonckheere, M Jones, P Jonsson, K K Joo, J Joshi, S Y Jun, A W Jung, T R Junk, A Juste, E Kajfasz, M Kambeitz, T Kamon, P E Karchin, D Karmanov, A Kasmi, Y Kato, I Katsanos, M Kaur, R Kehoe, S Kermiche, W Ketchum, J Keung, N Khalatyan, A Khanov, A Kharchilava, Y N Kharzheev, B Kilminster, D H Kim, H S Kim, J E Kim, M J Kim, S H Kim, S B Kim, Y J Kim, Y K Kim, N Kimura, M Kirby, I Kiselevich, J M Kohli, K Kondo, D J Kong, J Konigsberg, A V Kotwal, A V Kozelov, J Kraus, M Kreps, J Kroll, M Kruse, T Kuhr, A Kumar, A Kupco, M Kurata, T Kurča, V A Kuzmin, A T Laasanen, S Lammel, S Lammers, M Lancaster, K Lannon, G Latino, P Lebrun, H S Lee, H S Lee, J S Lee, S W Lee, W M Lee, X Lei, J Lellouch, S Leo, S Leone, J D Lewis, D Li, H Li, L Li, Q Z Li, J K Lim, A Limosani, D Lincoln, J Linnemann, V V Lipaev, E Lipeles, R Lipton, A Lister, H Liu, Q Liu, T Liu, Y Liu, A Lobodenko, S Lockwitz, A Loginov, M Lokajicek, R Lopes de Sa, D Lucchesi, A Lucà, J Lueck, P Lujan, P Lukens, R Luna-Garcia, G Lungu, A L Lyon, J Lys, R Lysak, A K A Maciel, R Madar, R Madrak, P Maestro, R Magaña-Villalba, S Malik, S Malik, V L Malyshev, G Manca, A Manousakis-Katsikakis, J Mansour, L Marchese, F Margaroli, P Marino, J Martínez-Ortega, K Matera, M E Mattson, A Mazzacane, P Mazzanti, R McCarthy, C L McGivern, R McNulty, A Mehta, P Mehtala, M M Meijer, A Melnitchouk, D Menezes, P G Mercadante, M Merkin, C Mesropian, A Meyer, J Meyer, T Miao, F Miconi, D Mietlicki, A Mitra, H Miyake, S Moed, N Moggi, N K Mondal, C S Moon, R Moore, M J Morello, A Mukherjee, M Mulhearn, Th Muller, P Murat, M Mussini, J Nachtman, Y Nagai, J Naganoma, E Nagy, I Nakano, A Napier, M Narain, R Nayyar, H A Neal, J P Negret, J Nett, P Neustroev, H T Nguyen, T Nigmanov, L Nodulman, S Y Noh, O Norniella, T Nunnemann, L Oakes, S H Oh, Y D Oh, T Okusawa, R Orava, J Orduna, L Ortolan, N Osman, C Pagliarone, A Pal, E Palencia, P Palni, V Papadimitriou, N Parashar, V Parihar, S K Park, W Parker, R Partridge, N Parua, A Patwa, G Pauletta, M Paulini, C Paus, B Penning, M Perfilov, Y Peters, K Petridis, G Petrillo, P Pétroff, T J Phillips, G Piacentino, E Pianori, J Pilot, K Pitts, C Plager, M-A Pleier, V M Podstavkov, L Pondrom, A V Popov, S Poprocki, K Potamianos, A Pranko, M Prewitt, D Price, N Prokopenko, F Prokoshin, F Ptohos, G Punzi, J Qian, A Quadt, B Quinn, P N Ratoff, I Razumov, I Redondo Fernández, P Renton, M Rescigno, F Rimondi, I Ripp-Baudot, L Ristori, F Rizatdinova, A Robson, T Rodriguez, S Rolli, M Rominsky, M Ronzani, R Roser, J L Rosner, A Ross, C Royon, P Rubinov, R Ruchti, F Ruffini, A Ruiz, J Russ, V Rusu, G Sajot, W K Sakumoto, Y Sakurai, A Sánchez-Hernández, M P Sanders, L Santi, A S Santos, K Sato, G Savage, V Saveliev, M Savitskyi, A Savoy-Navarro, L Sawyer, T Scanlon, R D Schamberger, Y Scheglov, H Schellman, P Schlabach, E E Schmidt, M Schott, C Schwanenberger, T Schwarz, R Schwienhorst, L Scodellaro, F Scuri, S Seidel, Y Seiya, J Sekaric, A Semenov, H Severini, F Sforza, E Shabalina, S Z Shalhout, V Shary, S Shaw, A A Shchukin, T Shears, P F Shepard, M Shimojima, O Shkola, M Shochet, I Shreyber-Tecker, V Simak, A Simonenko, P Skubic, P Slattery, K Sliwa, J R Smith, F D Snider, G R Snow, J Snow, S Snyder, S Söldner-Rembold, H Song, L Sonnenschein, V Sorin, K Soustruznik, R St Denis, M Stancari, J Stark, N Stefaniuk, D Stentz, D A Stoyanova, M Strauss, J Strologas, Y Sudo, A Sukhanov, I Suslov, L Suter, P Svoisky, K Takemasa, Y Takeuchi, J Tang, M Tecchio, P K Teng, J Thom, E Thomson, V Thukral, M Titov, D Toback, S Tokar, V V Tokmenin, K Tollefson, T Tomura, D Tonelli, S Torre, D Torretta, P Totaro, M Trovato, Y-T Tsai, D Tsybychev, B Tuchming, C Tully, F Ukegawa, S Uozumi, L Uvarov, S Uvarov, S Uzunyan, R Van Kooten, W M van Leeuwen, N Varelas, E W Varnes, I A Vasilyev, F Vázquez, G Velev, C Vellidis, A Y Verkheev, C Vernieri, L S Vertogradov, M Verzocchi, M Vesterinen, M Vidal, D Vilanova, R Vilar, J Vizán, M Vogel, P Vokac, G Volpi, P Wagner, H D Wahl, R Wallny, M H L S Wang, S M Wang, J Warchol, D Waters, G Watts, M Wayne, J Weichert, L Welty-Rieger, W C Wester, D Whiteson, A B Wicklund, S Wilbur, H H Williams, M R J Williams, G W Wilson, J S Wilson, P Wilson, B L Winer, P Wittich, M Wobisch, S Wolbers, H Wolfmeister, D R Wood, T Wright, X Wu, Z Wu, T R Wyatt, Y Xie, R Yamada, K Yamamoto, D Yamato, S Yang, T Yang, U K Yang, Y C Yang, W-M Yao, T Yasuda, Y A Yatsunenko, W Ye, Z Ye, G P Yeh, K Yi, H Yin, K Yip, J Yoh, K Yorita, T Yoshida, S W Youn, G B Yu, I Yu, J M Yu, A M Zanetti, Y Zeng, J Zennamo, T G Zhao, B Zhou, C Zhou, J Zhu, M Zielinski, D Zieminska, L Zivkovic, S Zucchelli
The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of sqrt[s]=1.96  TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is A_{FB}^{tt[over ¯]}=0...
January 26, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29436313/pre-eclampsia-and-the-risk-of-autism-spectrum-disorder-in-offspring-meta-analysis
#13
Berihun Assefa Dachew, Abdullah Mamun, Joemer Calderon Maravilla, Rosa Alati
BACKGROUND: Evidence about the effect of intrauterine exposure to pre-eclampsia on offspring autism-spectrum disorder (ASD) is not well established. Aims To examine the association between pre-eclampsia and ASD. METHOD: PubMed, Embase and PsycINFO databases were searched. Pooled relative risks (RR) with 95% confidence intervals were calculated. Subgroup and sensitivity analyses were performed. Heterogeneity was assessed using Cochran's Q- and the I 2-test. The presence of publication bias was evaluated by Egger's test and visual inspection of the symmetry in funnel plots...
January 24, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29434427/picosecond-laser-treatment-for-tattoos-and-benign-cutaneous-pigmented-lesions-secondary-publication
#14
REVIEW
Kenichiro Kasai
Background and aims: The selective removal of tattoos and benign cutaneous pigmented lesions with laser energy evolved rapidly with the development of the nanosecond-domain Q-switched laser (ns-laser). Recently, however, a series of picosecond-domain lasers (ps-lasers) with pulsewidths less than 1 ns has become commercially available, enabling more efficient and faster removal of pigmented lesions in the field of dermatologic laser surgery. Rationale behind the ps-laser: The efficacy of the ns-laser depended on the theory of selective photothermolysis, whereby an extremely short pulse width was delivered less than the thermal relaxation time (TRT) of a target...
December 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29434239/trigger-mechanism-for-the-abrupt-loss-of-energetic-ions-in-magnetically-confined-plasmas
#15
K Ida, T Kobayashi, M Yoshinuma, T Akiyama, T Tokuzawa, H Tsuchiya, K Itoh, S-I Itoh
Interaction between a quasi-stable stationary MHD mode and a tongue-shaped deformation is observed in the toroidal plasma with energetic particle driven MHD bursts. The quasi-stable stationary 1/1 MHD mode with interchange parity appears near the resonant rational surface of q = 1 between MHD bursts. The tongue-shaped deformation rapidly appears at the non-resonant non-rational surface as a localized large plasma displacement and then collapses (tongue event). It curbs the stationary 1/1 MHD mode and then triggers the collapse of energetic particle and magnetic field reconnection...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29434222/a-secondary-ret-mutation-in-the-activation-loop-conferring-resistance-to-vandetanib
#16
Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Satoru Nagatoishi, Kouhei Tsumoto, Yasushi Okuno, Kiyotaka Yoh, Neil Q McDonald, Koichi Goto
Resistance to vandetanib, a type I RET kinase inhibitor, developed in a patient with metastatic lung adenocarcinoma harboring a CCDC6-RET fusion that initially exhibited a response to treatment. The resistant tumor acquired a secondary mutation resulting in a serine-to-phenylalanine substitution at codon 904 in the activation loop of the RET kinase domain. The S904F mutation confers resistance to vandetanib by increasing the ATP affinity and autophosphorylation activity of RET kinase. A reduced interaction with the drug is also observed in vitro for the S904F mutant by thermal shift assay...
February 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29433936/microrna-219-reduces-viral-load-and-pathologic-changes-in-theiler-s-virus-induced-demyelinating-disease
#17
Ana Lis Moyano, Jeffrey Steplowski, Haibo Wang, Kyung-No Son, Diana I Rapolti, Jeffrey Marshall, Vince Elackattu, Michael S Marshall, Amy K Hebert, Cory R Reiter, Viviana Ulloa, Katarzyna C Pituch, Maria I Givogri, Q Richard Lu, Howard L Lipton, Ernesto R Bongarzone
Analysis of microRNA (miR) expression in the central nervous system white matter of SJL mice infected with the BeAn strain of Theiler's murine encephalomyelitis virus (TMEV) revealed a significant reduction of miR-219, a critical regulator of myelin assembly and repair. Restoration of miR-219 expression by intranasal administration of a synthetic miR-219 mimic before disease onset ameliorates clinical disease, reduces neurogliosis, and partially recovers motor and sensorimotor function by negatively regulating proinflammatory cytokines and virus RNA replication...
January 17, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29433311/determination-of-grayanotoxins-from-rhododendron-brachycarpum-in-dietary-supplements-and-homemade-wine-by-lc-q-tof-ms-and-lc-ms-ms
#18
Taeik Hwang, Eunyoung Noh, Ji Hye Jeong, Sung-Kwan Park, Dongwoo Shin, Hoil Kang
A sensitive and specific high-performance liquid chromatography?quadrupole?time-of-flight mass spec-trometry (LC-Q-TOF-MS) method combined with liquid chromatography?tandem mass spectrometry (LC-MS/MS) was developed for the determination of grayanotoxins I and III in dietary supplements and homemade wine. Grayanotoxins I and III were successfully extracted using solid-phase extraction cartridges, characterized by LC-Q-TOF-MS, and quantified by LC-MS/MS. The LC-MS/MS calibration curves were linear over concentrations of 10?100 ng mL?1 (grayanotoxin I) and 20?400 ng mL?1 (grayanotoxin III)...
February 13, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29432883/regulation-of-phosphorylation-of-ampa-glutamate-receptors-by-muscarinic-m4-receptors-in-the-striatum-in-vivo
#19
Li-Min Mao, Nan He, Dao-Zhong Jin, John Q Wang
The acetylcholine muscarinic 4 (M4) receptor is a principal muscarinic receptor subtype present in the striatum. Notably, Gαi/o-coupled M4 receptors and Gαs/Golf-coupled dopamine D1 receptors are coexpressed in striatonigral projection neurons and are thought to interact with each other to regulate neuronal excitability, although underlying molecular mechanisms are poorly understood. In this study, we investigated the role of M4 receptors in the regulation of phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the rat normal and dopamine-stimulated striatum in vivo...
February 9, 2018: Neuroscience
https://www.readbyqxmd.com/read/29432167/phylogenetic-classification-of-the-world-s-tropical-forests
#20
J W Ferry Slik, Janet Franklin, Víctor Arroyo-Rodríguez, Richard Field, Salomon Aguilar, Nikolay Aguirre, Jorge Ahumada, Shin-Ichiro Aiba, Luciana F Alves, Anitha K, Andres Avella, Francisco Mora, Gerardo A Aymard C, Selene Báez, Patricia Balvanera, Meredith L Bastian, Jean-François Bastin, Peter J Bellingham, Eduardo van den Berg, Polyanna da Conceição Bispo, Pascal Boeckx, Katrin Boehning-Gaese, Frans Bongers, Brad Boyle, Fabian Brambach, Francis Q Brearley, Sandra Brown, Shauna-Lee Chai, Robin L Chazdon, Shengbin Chen, Phourin Chhang, George Chuyong, Corneille Ewango, Indiana M Coronado, Jurgi Cristóbal-Azkarate, Heike Culmsee, Kipiro Damas, H S Dattaraja, Priya Davidar, Saara J DeWalt, Hazimah Din, Donald R Drake, Alvaro Duque, Giselda Durigan, Karl Eichhorn, Eduardo Schmidt Eler, Tsutomu Enoki, Andreas Ensslin, Adandé Belarmain Fandohan, Nina Farwig, Kenneth J Feeley, Markus Fischer, Olle Forshed, Queila Souza Garcia, Satish Chandra Garkoti, Thomas W Gillespie, Jean-Francois Gillet, Christelle Gonmadje, Iñigo Granzow-de la Cerda, Daniel M Griffith, James Grogan, Khalid Rehman Hakeem, David J Harris, Rhett D Harrison, Andy Hector, Andreas Hemp, Jürgen Homeier, M Shah Hussain, Guillermo Ibarra-Manríquez, I Faridah Hanum, Nobuo Imai, Patrick A Jansen, Carlos Alfredo Joly, Shijo Joseph, Kuswata Kartawinata, Elizabeth Kearsley, Daniel L Kelly, Michael Kessler, Timothy J Killeen, Robert M Kooyman, Yves Laumonier, Susan G Laurance, William F Laurance, Michael J Lawes, Susan G Letcher, Jeremy Lindsell, Jon Lovett, Jose Lozada, Xinghui Lu, Anne Mette Lykke, Khairil Bin Mahmud, Ni Putu Diana Mahayani, Asyraf Mansor, Andrew R Marshall, Emanuel H Martin, Darley Calderado Leal Matos, Jorge A Meave, Felipe P L Melo, Zhofre Huberto Aguirre Mendoza, Faizah Metali, Vincent P Medjibe, Jean Paul Metzger, Thiago Metzker, D Mohandass, Miguel A Munguía-Rosas, Rodrigo Muñoz, Eddy Nurtjahy, Eddie Lenza de Oliveira, Onrizal, Pia Parolin, Marc Parren, N Parthasarathy, Ekananda Paudel, Rolando Perez, Eduardo A Pérez-García, Ulf Pommer, Lourens Poorter, Lan Qi, Maria Teresa F Piedade, José Roberto Rodrigues Pinto, Axel Dalberg Poulsen, John R Poulsen, Jennifer S Powers, Rama Chandra Prasad, Jean-Philippe Puyravaud, Orlando Rangel, Jan Reitsma, Diogo S B Rocha, Samir Rolim, Francesco Rovero, Andes Rozak, Kalle Ruokolainen, Ervan Rutishauser, Gemma Rutten, Mohd Nizam Mohd Said, Felipe Z Saiter, Philippe Saner, Braulio Santos, João Roberto Dos Santos, Swapan Kumar Sarker, Christine B Schmitt, Jochen Schoengart, Mark Schulze, Douglas Sheil, Plinio Sist, Alexandre F Souza, Wilson Roberto Spironello, Tereza Sposito, Robert Steinmetz, Tariq Stevart, Marcio Seiji Suganuma, Rahayu Sukri, Aisha Sultana, Raman Sukumar, Terry Sunderland, Supriyadi, H S Suresh, Eizi Suzuki, Marcelo Tabarelli, Jianwei Tang, Ed V J Tanner, Natalia Targhetta, Ida Theilade, Duncan Thomas, Jonathan Timberlake, Márcio de Morisson Valeriano, Johan van Valkenburg, Tran Van Do, Hoang Van Sam, John H Vandermeer, Hans Verbeeck, Ole Reidar Vetaas, Victor Adekunle, Simone A Vieira, Campbell O Webb, Edward L Webb, Timothy Whitfeld, Serge Wich, John Williams, Susan Wiser, Florian Wittmann, Xiaobo Yang, C Yves Adou Yao, Sandra L Yap, Rakan A Zahawi, Rahmad Zakaria, Runguo Zang
Knowledge about the biogeographic affinities of the world's tropical forests helps to better understand regional differences in forest structure, diversity, composition, and dynamics. Such understanding will enable anticipation of region-specific responses to global environmental change. Modern phylogenies, in combination with broad coverage of species inventory data, now allow for global biogeographic analyses that take species evolutionary distance into account. Here we present a classification of the world's tropical forests based on their phylogenetic similarity...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
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