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https://www.readbyqxmd.com/read/29679266/changes-in-content-of-triterpenoids-and-polysaccharides-in-ganoderma-lingzhi-at-different-growth-stages
#1
Toshinori Nakagawa, Qinchang Zhu, Sonam Tamrakar, Yhiya Amen, Yasuhiro Mori, Hiroto Suhara, Shuhei Kaneko, Hiroko Kawashima, Kotaro Okuzono, Yoshiyuki Inoue, Koichiro Ohnuki, Kuniyoshi Shimizu
Ganoderma lingzhi is a traditional medicinal mushroom, and its extract contains many bioactive compounds. Triterpenoids and polysaccharides are the primary bioactive components that contribute to its medicinal properties. In this study, we quantified 18 triterpenoids, total triterpenoid content and total polysaccharide content in the ethanol and water extracts of G. lingzhi at different growth stages. Triterpenoids were quantified by liquid chromatograph-tandem mass spectrometry in the multiple-reaction-monitoring mode...
April 20, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29678511/correlation-of-the-new-york-heart-association-classification-and-the-cardiopulmonary-exercise-test-a-systematic-review
#2
Fang Yi Lim, Jonathan Yap, Fei Gao, Ling Li Teo, Carolyn S P Lam, Khung Keong Yeo
AIMS: The New York Heart Association (NYHA) classification is frequently used in the management of heart failure but may be limited by patient and physician subjectivity. Cardiopulmonary exercise testing (CPET) provides a potentially more objective measurement of functional status. We aim to study the correlation between NYHA classification and peak oxygen consumption (pVO2 ) on Cardiopulmonary Exercise Testing (CPET) within and across published studies. METHODS AND RESULTS: A systematic literature review on all studies reporting both NYHA class and CPET data was performed, and pVO2 from CPET was correlated to reported NYHA class within and across eligible studies...
April 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29675887/synthesis-and-biological-evaluation-of-4-sulfamoylphenyl-sulfocoumarin-carboxamides-as-selective-inhibitors-of-carbonic-anhydrase-isoforms-hca-ii-ix-and-xii
#3
Srinivas Angapelly, Andrea Angeli, Arbaj Jabbar Khan, Posa Venkata SriRamya, Claudiu Trandafir Supuran, Mohammed Arifuddin
With the aim to develop potent and selective human carbonic anhydrase inhibitors (hCAIs), we synthesized 4-sulfamoylphenyl/sulfocoumarin benzamides (5a-r and 7a-q) and evaluated for their inhibition profiles against five isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), the cytosolic CA I and II as well as transmembrane isozymes CA IV, IX and XII. Compounds 5a-r selectively inhibited the isoform hCA II in nanomolar range, being less effective against the other isoforms. As noticeable from the literature, sulfocoumarin (1,2-benzoxathiine 2,2-dioxide) act as "prodrug" inhibitor and get hydrolysed by the esterase CA activity to form 2-hydroxyphenyl-vinylsulfonic acid, which thereafter bind to the enzyme in a similar fashion like coumarins and sulfoxocoumarins...
April 19, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29675833/risks-of-restrictive-red-blood-cell-transfusion-strategies-in-patients-with-cardiovascular-disease-cvd-a-meta-analysis
#4
I Cortés-Puch, B M Wiley, J Sun, H G Klein, J Welsh, R L Danner, P Q Eichacker, C Natanson
AIM: To evaluate the risks of restrictive red blood cell transfusion strategies (haemoglobin 7-8 g dL-1 ) in patients with and without known cardiovascular disease (CVD). BACKGROUND: Recent guidelines recommend restrictive strategies for CVD patients hospitalised for non-CVD indications, patients without known CVD and patients hospitalised for CVD corrective procedures. METHODS/MATERIALS: Database searches were conducted through December 2017 for randomised clinical trials that enrolled patients with and without known CVD, hospitalised either for CVD-corrective procedures or non-cardiac indications, comparing effects of liberal with restrictive strategies on major adverse coronary events (MACE) and death...
April 19, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29675560/patterns-of-differential-gene-expression-in-a-cellular-model-of-human-islet-development-and-relationship-to-type-2-diabetes-predisposition
#5
Marta Perez-Alcantara, Christian Honoré, Agata Wesolowska-Andersen, Anna L Gloyn, Mark I McCarthy, Mattias Hansson, Nicola L Beer, Martijn van de Bunt
AIMS/HYPOTHESIS: Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet. Observed defects in insulin secretion could result from an impact of these variants on islet development and/or the function of mature islets. Most functional studies have focused on the latter, given limitations regarding access to human fetal islet tissue. Capitalising upon advances in in vitro differentiation, we characterised the transcriptomes of human induced pluripotent stem cell (iPSC) lines differentiated along the pancreatic endocrine lineage, and explored the contribution of altered islet development to the pathogenesis of type 2 diabetes...
April 19, 2018: Diabetologia
https://www.readbyqxmd.com/read/29674497/plasma-cell-proliferative-index-predicts-outcome-in-immunoglobulin-light-chain-amyloidosis-treated-with-stem-cell-transplantation
#6
M Hasib Sidiqi, Mohammed Aljama, Dragan Jevremovic, William G Morice, Michael Timm, Francis K Buadi, Rahma Warsame, Martha Q Lacy, Angela Dispenzieri, David Dingli, Wilson I Gonsalves, Shaji Kumar, Prashant Kapoor, Taxiarchis Kourelis, Nelson Leung, William J Hogan, Morie Gertz
The plasma cell proliferative index provides an insight into plasma cell biology in plasma cell disorders and is an important prognostic marker in myeloma and smoldering myeloma. We analyzed the prognostic impact of the plasma cell proliferative index in 513 patients with systemic AL Amyloidosis undergoing stem cell transplantation at the Mayo Clinic between January 2003 and 31 August 2016. Two cohorts were identified; Low or Elevated plasma cell proliferative index. Patients with an Elevated plasma cell proliferative index had more cardiac involvement (56% vs 44%; p=0...
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29674487/metals-in-urine-in-relation-to-the-prevalence-of-pre-diabetes-diabetes-and-atherosclerosis-in-rural-india
#7
Ganesan Velmurugan, Krishnan Swaminathan, Ganesh Veerasekar, Jonathan Q Purnell, Sundaresan Mohanraj, Mani Dhivakar, Anil Kumar Avula, Mathew Cherian, Nalla G Palaniswami, Thomas Alexander, Thalappil Pradeep
OBJECTIVE: Diabetes and cardiovascular diseases are growing burdens in rural communities worldwide. We have observed a high prevalence of diabetes among rural farming communities in India and sought to evaluate the association of non-traditional risk factors, such as metals, with diabetes and other cardiometabolic risk factors in this community. METHODS: Anthropometric measurements, chemistries and carotid intima-media thickness were determined in 865 participants of the Kovai Medical Center and Hospital-Nallampatti Non-Communicable Disease Study-I (KMCH-NNCD-I, 2015), a cross-sectional study conducted in a farming village in South India...
April 19, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29673416/identification-and-characterization-of-asulam-impurities-in-self-made-bulk-batch-synthesis-and-quantification-by-rp-hplc-method
#8
D Mahaboob Basha, G Venkata Reddy, Y Gopi Krishna, B E Kumara Swamy, Rajani Vijay
The first approach of this research paper explores the simultaneous characterization and determination of theAsulam active ingredient and its associated nine impurities in bulk batch production by the gradient reverse-phase high-performance liquid chromatographic (RP-HPLC) method. The best separation from its potential impurities and reproducible method was achieved by selecting the Cosmosil C-18 (250 × 4.6 mm, 5 μm particle size) analytical column with a run time of 40 min. The pumping chromatographic mobile phase was composed of 0...
April 19, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/29671361/liposomal-quercetin-potentiates-maxi-k-channel-openings-in-smooth-muscles-and-restores-its-activity-after-oxidative-stress
#9
Mariia I Melnyk, Dariia O Dryn, Lina T Al Kury, Alexander V Zholos, Anatoly I Soloviev
The effects of quercetin-loaded liposomes (PCL-Q) and their constituents, that is, free quercetin (Q) and 'empty' phosphatidylcholine vesicles (PCL), on maxi-K channel activity were studied in single mouse ileal myocytes before and after H2 O2 -induced oxidative stress. Macroscopic Maxi-K channel currents were recorded using whole-cell patch clamp techniques, while single BKCa channel currents were recorded in the cell-attached configuration. Bath application of PCL-Q (100 μg/ml of lipid and 3 μg/ml of quercetin) increased single Maxi-K channel activity more than threefold, from 0...
April 19, 2018: Journal of Liposome Research
https://www.readbyqxmd.com/read/29671249/importance-ratings-on-patient-reported-outcome-items-for-survivorship-care-comparison-between-pediatric-cancer-survivors-parents-and-clinicians
#10
Conor M Jones, Justin N Baker, Rachel M Keesey, Ruth J Eliason, Jennifer Q Lanctot, Jennifer L Clegg, Belinda N Mandrell, Kirsten K Ness, Kevin R Krull, Deokumar Srivastava, Christopher B Forrest, Melissa M Hudson, Leslie L Robison, I-Chan Huang
PURPOSE: To compare importance ratings of patient-reported outcomes (PROs) items from the viewpoints of childhood cancer survivors, parents, and clinicians for further developing short-forms to use in survivorship care. METHODS: 101 cancer survivors, 101 their parents, and 36 clinicians were recruited from St. Jude Children's Research Hospital. Participants were asked to select eight items that they deemed useful for clinical decision making from each of the four Patient-Reported Outcomes Measurement Information System Pediatric item banks...
April 18, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29669406/development-and-validation-study-of-the-internet-overuse-screening-questionnaire
#11
Han-Kyeong Lee, Hae-Woo Lee, Joo Hyun Han, Subin Park, Seok-Jin Ju, Kwanwoo Choi, Ji Hyeon Lee, Hong Jin Jeon
OBJECTIVE: Concerns over behavioral and emotional problems caused by excessive internet usage have been developed. This study intended to develop and a standardize questionnaire that can efficiently identify at-risk internet users through their internet usage habits. METHODS: Participants (n=158) were recruited at six I-will-centers located in Seoul, South Korea. From the initial 36 questionnaire item pool, 28 preliminary items were selected through expert evaluation and panel discussions...
April 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29669394/identification-of-metabolites-of-helicid-in-vivo-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#12
Xinpeng Diao, Man Liao, Xiaoye Cheng, Caijuan Liang, Yupeng Sun, Xia Zhang, Lantong Zhang
Helicid is an active natural aromatic phenolic glycoside ingredient originating from well-known traditional Chinese herb medicine and has the significant effects of sedative hypnosis, anti-inflammatory analgesia and antidepressant. In this study, we analyzed the potential metabolites of Helicid in rats by multiple mass defect filter (MMDF)and dynamic background subtraction (DBS)in ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS). Moreover, we used a novel data processing method 'key product ions (KPIs)' to rapidly detect and identifymetabolites as an assistant tool...
April 18, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29666865/preparation-of-lactic-acid-and-glucose-responsive-poly-%C3%AE%C2%B5-caprolactone-b-poly-ethylene-oxide-block-copolymer-micelles-using-phenylboronic-ester-as-a-sensitive-block-linkage
#13
David Vrbata, Mariusz Uchman
The present study describes the synthesis, self-assembly and responsiveness to glucose and lactic acid of biocompatible and biodegradable block copolymer micelles using phenylboronic ester as the linkage between hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene oxide) (PEO). The PCL block with pendant phenylboronic acid (PCLBA) was synthesized by combining ε-caprolactone (ε-CL) ring-opening polymerisation (ROP), using 4-hydroxymethyl(phenylboronic) acid pinacolate as the initiator, and pinacol deprotection...
April 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29666415/canonical-pi3k%C3%AE-signaling-in-myeloid-cells-restricts-trypanosoma-cruzi-infection-and-dampens-chagasic-myocarditis
#14
Maria C Silva, Marcela Davoli-Ferreira, Tiago S Medina, Renata Sesti-Costa, Grace K Silva, Carla D Lopes, Lucas E Cardozo, Fábio N Gava, Konstantina Lyroni, Fabrício C Dias, Amanda F Frade, Monique Baron, Helder I Nakaya, Florêncio Figueiredo, José C Alves-Filho, Fernando Q Cunha, Christos Tsatsanis, Christophe Chevillard, Edecio Cunha-Neto, Emilio Hirsch, João S Silva, Thiago M Cunha
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi (T. cruzi) and is an important cause of severe inflammatory heart disease. However, the mechanisms driving Chagas disease cardiomyopathy have not been completely elucidated. Here, we show that the canonical PI3Kγ pathway is upregulated in both human chagasic hearts and hearts of acutely infected mice. PI3Kγ-deficient mice and mutant mice carrying catalytically inactive PI3Kγ are more susceptible to T. cruzi infection. The canonical PI3Kγ signaling in myeloid cells is essential to restrict T...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29666391/icosahedra-clustering-and-short-range-order-in-ni-nb-zr-amorphous-membranes
#15
S Sarker, D Isheim, G King, Q An, D Chandra, S I Morozov, K Page, J N Wermer, D N Seidman, M Dolan
Crystalline Pd/Pd-Ag membranes are widely used for hydrogen separation from CO2 and other gases in power generation applications. To substitute these high cost noble metal alloy membranes, the Ni-Nb-Zr amorphous alloys are being developed that exhibit relatively high permeability of hydrogen between 200-400 °C. Atom probe tomography (APT) experiments performed on these ribbons revealed nm-scale Nb-rich and Zr-rich regions (clusters) embedded in a ternary matrix, indicating phase separation within the Ni-Nb-Zr amorphous alloy...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665745/heterogeneity-in-ppv-of-ras-mutations-in-cytologically-indeterminate-thyroid-nodules
#16
Fadi Nabhan, Kyle Porter, Mark Lupo, Gregory W Randolph, Kepal Narendra Patel, Richard T Kloos
BACKGROUND: RAS mutations are common in the available mutational analysis of cytologically indeterminate (Cyto-I) thyroid nodules. However, their reported positive predictive value (PPV) for cancer is widely variable. The reason for this variability is unknown and it causes clinical management uncertainty. We performed a systematic review evaluating the PPV for cancer in RAS mutation positive Cyto-I nodules and considered variables that might affect residual heterogeneity across the different studies...
April 18, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29665421/uhplc-q-tof-ms-ms-based-screening-and-identification-of-the-metabolites-in-vivo-after-oral-administration-of-betulin
#17
Wendan Zhang, Honghong Jiang, Miaomiao Jin, Qiao Wang, Qian Sun, Yingfeng Du, Liang Cao, Huijun Xu
Betulin is an active natural pentacyclic triterpene ingredient with valuable anti-cancer and anti-HIV efficacies. In the present study, an efficient approach was developed to screening and identification of metabolites and to assess the metabolic profiles of betulin in vivo using UHPLC-Q-TOF-MS/MS system based on multiple mass defect filter data acquisition (MMDF) and multiple data processing techniques. Based on the proposed method, 56 phase I and 6 phase II metabolites were detected in rats after oral administration of betulin...
April 14, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29663320/predictors-of-complications-after-direct-to-implant-breast-reconstruction-with-an-acellular-dermal-matrix-from-a-multicentre-randomized-clinical-trial
#18
V L Negenborn, R E G Dikmans, M B Bouman, H A H Winters, J W R Twisk, P Q Ruhé, M A M Mureau, J M Smit, S Tuinder, J Hommes, Y Eltahir, N A S Posch, J M van Steveninck-Barends, M A Meesters-Caberg, R R W J van der Hulst, M J P F Ritt, M G Mullender
BACKGROUND: In the multicentre randomized trial BRIOS (Breast Reconstruction In One Stage), direct-to-implant (DTI) breast reconstruction with an acellular dermal matrix (ADM) was associated with a markedly higher postoperative complication rate compared with two-stage tissue expander/implant breast reconstruction. This study aimed to identify factors that contribute to the occurrence of complications after DTI ADM-assisted breast reconstruction. METHODS: Data were obtained from the BRIOS study, including all patients treated with DTI ADM-assisted breast reconstruction...
April 16, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29662750/return-to-play-in-adolescent-athletes-with-symptomatic-spondylolysis-without-listhesis-a-meta-analysis
#19
REVIEW
Samuel C Overley, Steven J McAnany, Steve Andelman, Jun Kim, Robert K Merrill, Samuel K Cho, Sheeraz A Qureshi, Andrew C Hecht
Study Design: Meta-analysis. Objectives: To assess return to play (RTP) rates in adolescent athletes with lumbar spondylolysis without spondylolisthesis treated conservatively or operatively. Methods: A review of Medline, EMBASE, and Cochrane Reviews was performed. The pooled results were performed by calculating the effect size based on the logit event rate. Studies were weighted by the inverse of the variance. Confidence intervals were reported at 95%...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29661532/measurement-of-physical-performance-by-field-tests-in-programs-of-cardiac-rehabilitation-a-systematic-review-and-meta-analysis
#20
REVIEW
Cristiane Travensolo, Karla Goessler, Roberto Poton, Roberta Ramos Pinto, Marcos Doederlein Polito
INTRODUCTION: The literature concerning the effects of cardiac rehabilitation (CR) on field tests results is inconsistent. PURPOSE: To perform a systematic review with meta-analysis on field tests results after programs of CR. METHODS: Studies published in PubMed and Web of Science databases until May 2016 were analyzed. The standard difference in means correct by bias (Hedges' g) was used as effect size (g) to measure que amount of modifications in performance of field tests after CR period...
April 13, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
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