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https://www.readbyqxmd.com/read/28823010/the-reliability-of-rifampicin-resistance-as-a-proxy-for-multidrug-resistant-tuberculosis-a-systematic-review-of-studies-from-iran
#1
REVIEW
M J Nasiri, S Zamani, A Pormohammad, M M Feizabadi, H R Aslani, M Amin, R Halabian, A A Imani Fooladi
In Iran, patients showing rifampicin (RIF) resistance detected by the Xpert® MTB/RIF assay are considered as candidates for multidrug-resistant tuberculosis (MDR-TB) treatment. Despite the fact that RIF resistance has been used as a proxy for MDR-TB, little is known about the proportion of isoniazid (INH) resistance patterns in RIF-resistant TB. We systematically searched MEDLINE, Embase, and other databases up to March 2017 for studies addressing the proportion of INH resistance patterns in RIF-resistant TB in Iran...
August 19, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28821766/protein-composition-analysis-of-polyhedra-matrix-of-bombyx-mori-nucleopolyhedrovirus-bmnpv-showed-powerful-capacity-of-polyhedra-to-encapsulate-foreign-proteins
#2
Zhong-Jian Guo, Meng-Han Yu, Xian-Yun Dong, Wei-Li Wang, Ting Tian, Xian-Yin Yu, Xu-Dong Tang
Polyhedra can encapsulate other proteins and have potential applications as protein stabilizers. The extremely stable polyhedra matrix may provide a platform for future engineered micro-crystal devices. However, the protein composition of the polyhedra matrix remains largely unknown. In this study, the occlusion-derived virus (ODV)-removed BmNPV polyhedra matrix fraction was subjected to SDS-PAGE and then an LC-ESI-MS/MS analysis using a Thermo Scientific Q Exactive mass spectrometer. In total, 28 host and 91 viral proteins were identified...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821142/manufacture-of-requeij%C3%A3-o-cremoso-processed-cheese-with-galactooligosaccharide
#3
P C Belsito, M V S Ferreira, L P Cappato, R N Cavalcanti, V A S Vidal, T C Pimentel, E A Esmerino, C F Balthazar, R P C Neto, M I B Tavares, P B Zacarchenco, M Q Freitas, M C Silva, R S L Raices, G M Pastore, M A R Pollonio, A G Cruz
The addition of galactooligosaccharide, (GOS, 0, 1.5, 3 or 4g/100g) on the quality parameters of requeijão cremoso was investigated. Chemical characteristics (pH, moisture, fat and protein), color (L*, a*, b*), water mobility by TD- nuclear magnetic resonance, rheology (flow curve and oscillatory tests), microstructure and sensory acceptance (consumer test) were evaluated. The addition of GOS provided a denser and compact structure and reduced number and size of fat globules. Increased GOS level (3 and 4g/100g) improved the softness and spreadability (decrease of G', G″ and apparent viscosity and an increase of tan δ and melting index) and impacted positively on the aroma and taste of the requeijão cremoso...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28819746/the-effects-of-resistance-exercise-training-on-anxiety-a-meta-analysis-and-meta-regression-analysis-of-randomized-controlled-trials
#4
REVIEW
Brett R Gordon, Cillian P McDowell, Mark Lyons, Matthew P Herring
BACKGROUND: The salutary effects of resistance exercise training (RET) are well established, including increased strength and function; however, less is known regarding the effects of RET on mental health outcomes. Aerobic exercise has well-documented positive effects on anxiety, but a quantitative synthesis of RET effects on anxiety is needed. OBJECTIVES: To estimate the population effect size for resistance exercise training (RET) effects on anxiety and to determine whether variables of logical, theoretical, and/or prior empirical relation to anxiety moderate the overall effect...
August 17, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28817574/diffusion-tensor-imaging-profiles-reveal-specific-neural-tract-distortion-in-normal-pressure-hydrocephalus
#5
Nicole C Keong, Alonso Pena, Stephen J Price, Marek Czosnyka, Zofia Czosnyka, Elise E DeVito, Charlotte R Housden, Barbara J Sahakian, John D Pickard
BACKGROUND: The pathogenesis of normal pressure hydrocephalus (NPH) remains unclear which limits both early diagnosis and prognostication. The responsiveness to intervention of differing, complex and concurrent injury patterns on imaging have not been well-characterized. We used diffusion tensor imaging (DTI) to explore the topography and reversibility of white matter injury in NPH pre- and early after shunting. METHODS: Twenty-five participants (sixteen NPH patients and nine healthy controls) underwent DTI, pre-operatively and at two weeks post-intervention in patients...
2017: PloS One
https://www.readbyqxmd.com/read/28817364/association-between-dietary-phytoestrogens-intakes-and-prostate-cancer-risk-in-sicily
#6
Giorgio I Russo, Marina Di Mauro, Federica Regis, Giulio Reale, Daniele Campisi, Marina Marranzano, Arturo Lo Giudice, Tatiana Solinas, Massimo Madonia, Sebastiano Cimino, Giuseppe Morgia
OBJECTIVE: In this study we aimed to investigate the association between dietary phytoestrogen consumption and prostate cancer in a sample of southern Italian individuals. METHODS: A population-based case-control study on the association between prostate cancer and dietary factors was conducted from January 2015 to December 2016 in a single institution of the municipality of Catania, southern Italy (Registration number: 41/2015). A total of 118 histopathological-verified prostate cancer (PCa) cases and a total of 222 controls were collected...
August 17, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28816985/the-curative-effect-of-liposuction-curettage-in-the-treatment-of-bromhidrosis-a-meta-analysis
#7
Lianbo Zhang, Feifei Chen, Jiao Kong, Zhuonan Li, Xiaoqiang Wen, Jun Liu
BACKGROUND: We aimed to understand the curative effect of liposuction curettage (LC) in the treatment of bromhidrosis. METHODS: Relevant studies published before January 2017were searched from the PubMed, Embase, Cochrane Library, Wanfang, VIP, and China National Knowledge Infrastructure databases. Parameters including recurrence, complications, complete response, and overall response were assessed. Meta-analysis was performed using the R 3.12 statistical package...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816893/periarticular-liposomal-bupivacaine-injection-versus-intra-articular-bupivacaine-infusion-catheter-for-analgesia-after-total-knee-arthroplasty-a-double-blinded-randomized-controlled-trial
#8
Eric B Smith, Gregory S Kazarian, Mitchell G Maltenfort, Jess H Lonner, Peter F Sharkey, Robert P Good
BACKGROUND: Intra-articular bupivacaine hydrochloride (HCl) infusion catheters and periarticular injections of liposomal bupivacaine are often used as postoperative local anesthetics. The purpose of this study was to compare the efficacies of these local anesthetics following total knee arthroplasty. METHODS: This study was a superiority trial with a randomized, controlled, double-blinded design. Patients were randomly assigned to either delivery of bupivacaine HCl by the ON-Q* Pain Relief System pump (n = 96) or by an injection of Exparel (liposomal bupivacaine) (n = 104)...
August 16, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28816417/docking-field-based-qsar-and-pharmacophore-studies-on-the-substituted-pyrimidine-derivatives-targeting-hiv-1-reverse-transcriptase
#9
Ningning Fan, Shuang Zhang, Tao Sheng, Liang Zhao, Zhenming Liu, Junyi Liu, Xiaowei Wang
HIV-1 reverse transcriptase (RT) is one of the most important enzymes required for viral replication, thus acting as an attractive target for anti-retroviral therapy. Pyrimidine analogues reportedly have selective inhibition on HIV-1 RT with favorable antiviral activities in our previous study. To further explore the relationship between inhibitory activity and pharmacophoric characteristics, field-based QSAR models were generated and validated using Schrodinger Suite (correlation coefficient of 0.8078, cross-validated value of 0...
August 17, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28816281/-application-of-flurbiprofen-axetil-in-pain-management-associated-during-transrectal-ultrasound-guided-prostate-biopsy
#10
K Lan, W B Yang, X W Zhang, W J Bai, Q Li, T Xu
OBJECTIVE: To examine the effects of perioperative intravenous administration of flurbiprofen axetil (FA) on pain associated with transrectal ultrasound-guided prostate biopsy. METHODS: This was a randomized,controlled study. Eighty-one patients who underwent 12 core prostate biopsy were included in the study. The patients were randomly assigned to one of three groups (n=27 in each) by type of procedure during prostate biopsy. Group intrarectal local anesthesia (IRLA) received intrarectal 5% (0...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28815810/proteome-characterization-of-human-pancreatic-cyst-fluid-from-intraductal-papillary-mucinous-neoplasm-by-lc-ms-ms
#11
Joonho Park, Dohyun Han, Misol Do, Jongmin Woo, Joseph I Wang, Youngmin Han, Wooil Kwon, Sun-Whe Kim, Jin-Young Jang, Youngsoo Kim
RATIONALE: In recent years, the molecular components of pancreatic cyst fluid has been used for diagnosis and prognosis. Because the protein markers that are currently used in clinical tests are unreliable, proteomic studies to find new protein markers are being conducted. However, such researches have been limited due to the complexity of pancreatic cyst fluid and the immaturity of proteomic techniques. METHODS: To overcome these limitations and provide a pancreatic cyst proteome dataset, we examined cyst fluid proteome with tandem mass spectrometry...
August 15, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28814757/top-canopy-nitrogen-allocation-linked-to-increased-grassland-carbon-uptake-in-stands-of-varying-species-richness
#12
Alexandru Milcu, Arthur Gessler, Christiane Roscher, Laura Rose, Zachary Kayler, Dörte Bachmann, Karin Pirhofer-Walzl, Saša Zavadlav, Lucia Galiano, Tina Buchmann, Michael Scherer-Lorenzen, Jacques Roy
Models predict that vertical gradients of foliar nitrogen (N) allocation, increasing from bottom to top of plant canopies, emerge as a plastic response to optimise N utilisation for carbon assimilation. While this mechanism has been well documented in monocultures, its relevance for mixed stands of varying species richness remains poorly understood. We used 21 naturally assembled grassland communities to analyse the gradients of N in the canopy using N allocation coefficients (K N ) estimated from the distribution of N per foliar surface area (KN-F) and ground surface area (KN-G)...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813787/clarification-of-muscle-synergy-structure-during-standing-up-motion-of-healthy-young-elderly-and-post-stroke-patients
#13
N Yang, Q An, H Yamakawa, Y Tamura, A Yamashita, K Takahashi, M Kinomoto, H Yamasaki, M Itkonen, F S Alnajjar, S Shimoda, H Asama, N Hattori, I Miyai
Standing-up motion is an important daily activity. It has been known that elderly and post-stroke patients have difficulty in performing standing-up motion. The standing-up motion is retrained by therapists to maximize independence of the elderly and post-stroke patients, but it is not clear how the elderly and post-stroke patients control their redundant muscles to achieve standing-up motion. This study employed the concept of muscle synergy to analyze how healthy young adults, healthy elderly people and post-stroke patients control their muscles...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28812209/effect-of-vitamin-d-supplementation-in-chronic-widespread-pain-a-systematic-review-and-meta-analysis
#14
Wai Chung Yong, Anawin Sanguankeo, Sikarin Upala
Chronic non-specific widespread pain (CWP) including fibromyalgia (FMS) is characterized by widespread pain, reduced pain threshold, and multiple tender points on examination, causing disability and decreased quality of life. Vitamin D has been proposed as an associated factor in CWP. This meta-analysis aimed to explore the benefit of vitamin D supplementation in the management of CWP. A comprehensive search of the CENTRAL, MEDLINE, and Embase databases was performed from inception through January 2017. The inclusion criterion was the randomized clinical trials' evaluating the effects of vitamin D treatment in adult subjects with CWP or FMS...
August 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28812188/comparative-efficacy-of-cold-polypectomy-techniques-for-diminutive-colorectal-polyps-a-systematic-review-and-network-meta-analysis
#15
Yoon Suk Jung, Chan Hyuk Park, Eunwoo Nam, Chang Soo Eun, Dong Il Park, Dong Soo Han
BACKGROUND: Although cold polypectomy techniques are preferred over polypectomy with electrocautery in the management of diminutive polyps, comprehensive comparisons among various cold polypectomy techniques have not yet been fully performed. METHODS: We searched for all relevant randomized controlled trials published up until October 2016 examining the efficacy of cold polypectomy techniques for diminutive polyps. Cold polypectomy techniques were classified as cold forceps polypectomy (CFP), jumbo forceps polypectomy (JFP), traditional cold snare polypectomy (CSP), and dedicated CSP, according to the type of device...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28810251/a-prospective-randomized-open-label-blinded-endpoint-study-exploring-platelet-response-to-half-dose-prasugrel-and-ticagrelor-in-patients-with-the-acute-coronary-syndrome-hope-tailor-study
#16
Cai De Jin, Moo Hyun Kim, Junghee Bang, Victor Serebruany
BACKGROUND: The optimal dosing of novel oral P2Y12 receptor platelet inhibitors such as prasugrel or ticagrelor is unclear and especially challenging in East Asians. We hypothesize that half-dose prasugrel and ticagrelor may be sufficient for long-term maintenance management in Korean patients with the acute coronary syndrome (ACS) compared with conventional dosages. DESIGN: HOPE-TAILOR (Half Dose of Prasugrel and Ticagrelor in Platelet Response after Acute Coronary Syndromes) is a prospective, randomized, open-label, blinded, endpoint (PROBE) single-center, clinical trial...
August 16, 2017: Cardiology
https://www.readbyqxmd.com/read/28809927/in-middle-aged-and-old-obese-patients-training-intervention-reduces-leptin-level-a-meta-analysis
#17
Ildikó Rostás, László Pótó, Péter Mátrai, Péter Hegyi, Judit Tenk, András Garami, Anita Illés, Margit Solymár, Erika Pétervári, Ákos Szűcs, Andrea Párniczky, Dániel Pécsi, Zoltán Rumbus, Csaba Zsiborás, Nóra Füredi, Márta Balaskó
BACKGROUND: Leptin is one of the major adipokines in obesity that indicates the severity of fat accumulation. It is also an important etiological factor of consequent cardiometabolic and autoimmune disorders. Aging has been demonstrated to aggravate obesity and to induce leptin resistance and hyperleptinemia. Hyperleptinemia, on the other hand, may promote the development of age-related abnormalities. While major weight loss has been demonstrated to ameliorate hyperleptinemia, obese people show a poor tendency to achieve lasting success in this field...
2017: PloS One
https://www.readbyqxmd.com/read/28807981/delineation-of-the-timing-of-second-line-therapy-post-autologous-stem-cell-transplant-in-patients-with-al-amyloidosis
#18
Yi L Hwa, Rahma Warsame, Morie A Gertz, Francis K Buadi, Martha Q Lacy, Shaji K Kumar, David Dingli, Steve R Zeldenrust, Nelson Leung, Suzanne R Hayman, Prashant Kapoor, Wilson I Gonsalves, Taxiarchis V Kourelis, Stephen Russell, Ronald S Go, Miriam A Hobbs, Amie L Fonder, S Vincent Rajkumar, Angela Dispenzieri
Among patients with immunoglobulin light chain (AL) amyloidosis, there is little consensus on when reinstitution of chemotherapy should occur. We conducted a retrospective study to evaluate the patterns of relapse or progression (R/P) and the timing of re-initiating therapy among 235 patients initially treated with ASCT at Mayo Clinic. The median time from ASCT to second-line therapy was 24.3 months. At the time of restarting therapy, median dFLC was 9.9 mg/dL (42% of diagnosis value); 32% had a dFLC< 5mg/dL; and 63% met criteria for organ R/P...
August 14, 2017: Blood
https://www.readbyqxmd.com/read/28807245/portal-vein-ligation-versus-portal-vein-embolization-for-induction-of-hypertrophy-of-the-future-liver-remnant-a-systematic-review-and-meta-analysis
#19
REVIEW
C J Isfordink, M Samim, M N G J A Braat, A M Almalki, J Hagendoorn, I H M Borel Rinkes, I Q Molenaar
An important risk of major hepatic resection is postoperative liver failure, which is directly related to insufficient future liver remnant (FLR). Portal vein embolization (PVE) and portal vein ligation (PVL) can minimize this risk by inducing hypertrophy of the FLR. The aim of this systematic review and meta-analysis was to compare the efficacy and safety of PVE and PVL for FLR hypertrophy. A systematic search was conducted on the17(th) of January 2017. The methodological quality of the studies was assessed using the Oxford Critical Appraisal Skills Program for cohort studies...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28805877/a-dna-bipedal-nanowalker-with-a-piston-like-expulsion-stroke
#20
Q Y Yeo, I Y Loh, S R Tee, Y H Chiang, J Cheng, M H Liu, Z S Wang
Artificial molecular walkers beyond burn-bridge designs are important for nanotechnology, but their systematic development remains difficult. Herein, we have reported a new rationally designed DNA walker-track system and experimentally verified a previously proposed general expulsion regime for implementing non-burn-bridge nanowalkers. The DNA walker has an optically powered engine motif that reversibly extends and contracts the walker via a quadruplex-duplex conformational change. The walker's extension is an energy-absorbing and force-generating process, which drives the walker's leg dissociation off-track in a piston-like expulsion stroke...
August 14, 2017: Nanoscale
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