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https://www.readbyqxmd.com/read/28214938/baseline-trace-metals-in-patella-caerulea-in-a-central-tyrrhenian-ecosystem-pontine-islands-archipelago-and-lazio-region-coastal-sites-italy
#1
Marcelo Enrique Conti, Giustino Mele, Maria Grazia Finoia
In this study, we tested the aptitude of the gastropod mollusk Patella caerulea as biomonitor of elemental pollution in seawater of a central Tyrrhenian ecosystem (Pontine Islands archipelago and Lazio region coastal sites, Italy). Concentrations of Cd, Cr, Cu, Ni, Pb, and Zn were measured in 120 individuals collected in six strategic locations in two sampling campaigns during 2011 and 2012. Samples of surrounding seawater were also collected in the same sites and tested for the same metals in order to obtain the respective concentration factors (CFs)...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28214851/lysophosphatidic-acid-promotes-epithelial-to-mesenchymal-transition-in-ovarian-cancer-cells-by-repressing-sirt1
#2
Upasana Ray, Sib Sankar Roy, Shreya Roy Chowdhury
BACKGROUND/AIMS: Epithelial-to-mesenchymal transition (EMT) plays an essential role in the transition from early to invasive phenotype, however the underlying mechanisms still remain elusive. Herein, we propose a mechanism through which the class-III deacetylase SIRT1 regulates EMT in ovarian cancer (OC) cells. METHODS: Expression analysis was performed using Q-PCR, western blot, immunofluorescence and fluorescence-IHC study. Matrigel invasion assay was used for the invasion study...
February 14, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214137/japanese-guidelines-for-allergic-rhinitis-2017
#3
REVIEW
Kimihiro Okubo, Yuichi Kurono, Keiichi Ichimura, Tadao Enomoto, Yoshitaka Okamoto, Hideyuki Kawauchi, Harumi Suzaki, Shigeharu Fujieda, Keisuke Masuyama
Like asthma and atopic dermatitis, allergic rhinitis is an allergic disease, but of the three, it is the only type I allergic disease. Allergic rhinitis includes pollinosis, which is intractable and reduces quality of life (QOL) when it becomes severe. A guideline is needed to understand allergic rhinitis and to use this knowledge to develop a treatment plan. In Japan, the first guideline was prepared after a symposium held by the Japanese Society of Allergology in 1993. The current 8th edition was published in 2016, and is widely used today...
February 14, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28213289/quercetin-and-pioglitazone-synergistically-reverse-endothelial-dysfunction-in-isolated-aorta-from-fructose-streptozotocin-f-stz-induced-diabetic-rats
#4
Thubasni Kunasegaran, Mohd Rais Mustafa, Francis I Achike, Dharmani Devi Murugan
Pioglitazone is an anti-diabetic drug with potential to cause adverse effects following prolonged use. This study, therefore, investigated the effects of combination treatment of a subliminal concentration of pioglitazone and quercetin, a potent antioxidant, on vascular reactivity of aorta isolated from fructose-streptozotocin (F-STZ)-induced diabetic rats. Relaxation to acetylcholine and sodium nitroprusside, and contraction to phenylephrine were tested in organ bath chambers following pre-incubation with vehicle (DMSO; 0...
February 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28212927/patients-with-chronic-dizziness-following-traumatic-head-injury-typically-have-multiple-diagnoses-involving-combined-peripheral-and-central-vestibular-dysfunction
#5
Q Arshad, R E Roberts, H Ahmad, R Lobo, M Patel, T Ham, D J Sharp, B M Seemungal
OBJECTIVE: We hypothesised that chronic vestibular symptoms (CVS) of imbalance and dizziness post-traumatic head injury (THI) may relate to: (i) the occurrence of multiple simultaneous vestibular diagnoses including both peripheral and central vestibular dysfunction in individual patients increasing the chance of missed diagnoses and suboptimal treatment; (ii) an impaired response to vestibular rehabilitation since the central mechanisms that mediate rehabilitation related brain plasticity may themselves be disrupted...
February 7, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28212587/prevalence-of-urinary-incontinence-in-females-performing-high-impact-exercises
#6
Magdaléna Hagovska, Ján Švihra, Alena Buková, Agáta Hrobacz, Dana Dračková, Viera Švihrová, Lenka Kraus
The aim of this cross-sectional study was to monitor the prevalence of symptoms of stress (SUI) and mixed urinary incontinence (MUI) in sportswomen performing high-impact exercises. A further objective was to compare the symptoms of urinary incontinence (UI) and quality of life in sportswomen. We used the International Consultation on Incontinence Questionnaire (ICIQ-SF), the Overactive Bladder Questionnaire (OAB-q), the Urinary Incontinence Quality of Life Scale (I-QOL) and the International Physical Activity Questionnaire (IPAQ), short version...
February 17, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28211889/clinical-utility-of-the-revised-international-staging-system-in-unselected-patients-with-newly-diagnosed-and-relapsed-multiple-myeloma
#7
N Tandon, S V Rajkumar, B LaPlant, A Pettinger, M Q Lacy, A Dispenzieri, F K Buadi, M A Gertz, S R Hayman, N Leung, R S Go, D Dingli, P Kapoor, Y Lin, Y L Hwa, A L Fonder, M A Hobbs, S R Zeldenrust, J A Lust, W I Gonsalves, S J Russell, S K Kumar
We analyzed the utility of Revised International staging system (RISS) in an unselected cohort of newly diagnosed multiple myeloma (NDMM; cohort 1), and relapsed/refractory multiple myeloma (RRMM; cohort 2) patients. Cohort 1 included 1900 patients seen within 90 days of diagnosis, from 2005 to 2015, while cohort 2 had 887 patients enrolled in 23 clinical trials at Mayo Clinic. The overall survival (OS) and progression-free survival (PFS) was calculated from the time since diagnosis or trial registration. The median estimated follow up was 5 and 2...
February 17, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28209553/intraspecific-genetic-variability-in-a-population-of-moroccan-leishmania-infantum-revealed-by-pcr-rflp-of-kdna-minicircles
#8
Adil El Hamouchi, Rajaa Ejghal, Moustapha Hida, Meryem Lemrani
In Morocco, Leishmania infantum is the main etiologic agent of human and canine visceral leishmaniasis (VL). This species has been proven to be an opportunistic agent in HIV+ patients and is also responsible of sporadic cutaneous leishmaniasis (CL).This work aims to evaluate the genetic variability of Moroccan L. infantum strains based on PCR-RFLP analysis of the kinetoplastid DNA (kDNA) minicircles. A total of 75 DNA samples extracted from positive Giemsa-stained smears (n=32) and from L. infantum cultures (n=43) was studied...
February 13, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28209239/decreased-reg1%C3%AE-expression-suppresses-growth-invasion-and-angiogenesis-of-bladder-cancer
#9
J Geng, J Fan, Q Wang, X-P Zhang, L Kang, Q-Y Li, Y-F Xu, B Peng, J-H Zheng, X-D Yao
BACKGROUND: Previous study has indicated association between REG1α and bladder cancer. The aim of this study was to investigate the role of Regenerating gene I alpha (REG1α) in bladder cancer. METHODS: The role of REG1α in bladder cancer cell proliferation, migration and VEGF-induced angiogenesis was explored in vitro and in vivo. Immunohistochemistry (IHC) analysis was assessed to determine the expression of REG1α in ten paired bladder cancer and adjacent non-cancerous tissues, and in 296 bladder cancer samples...
February 2, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28209036/-primary-culture-and-functional-identification-of-distal-pulmonary-artery-smooth-muscle-cells-in-mice
#10
M C Li, Y Q Chen, C T Zhang, Q Jiang, W J Lu, J Wang
Objective: To establish a method of isolation and primary culture of mice distal pulmonary artery smooth muscle cells (PASMCs) and identify the functional properties. Methods: PASMCs were harvested from the distal pulmonary artery (PA) tissue of mice by enzymatic digestion of collagenaseⅠand papain; and the growth characteristics were observed under inverted microscope and identified by Immunofluorescence technique. Effects on the intracellular calcium ion concentration of distal PASMCs were detected by Fura-2-AM fluorescent probe tracer under a fluorescence microscope in Krebs solution containing clopiazonic acid (CPA) and nifedipin (Nif)...
February 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28208817/validity-of-the-food-frequency-questionnaire-assessing-the-folate-intake-in-women-of-reproductive-age-living-in-a-country-without-food-fortification-application-of-the-method-of-triads
#11
Milica Zekovic, Marija Djekic-Ivankovic, Marina Nikolic, Mirjana Gurinovic, Dusanka Krajnovic, Marija Glibetic
The study aimed to examine the external validity of the Folate Food Frequency Questionnaire (F-FFQ) designed for assessing the folate intake in Serbian women of reproductive age. The F-FFQ was tested against repeated 24 h dietary recalls and correspondent nutritional biomarkers (red blood cells (RBC) and serum folate concentrations) using the method of triads. In a cross sectional study, 503 women aged 18-49 years completed dietary questionnaires and representative validation subsample (n = 50) provided fasting blood samples for biomarker analyses...
February 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28208729/altered-intracellular-milieu-of-adar2-deficient-motor-neurons-in-amyotrophic-lateral-sclerosis
#12
REVIEW
Takenari Yamashita, Megumi Akamatsu, Shin Kwak
Transactive response DNA-binding protein (TDP-43) pathology, and failure of A-to-I conversion (RNA editing) at the glutamine/arginine (Q/R) site of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit GluA2, are etiology-linked molecular abnormalities that concomitantly occur in the motor neurons of most patients with amyotrophic lateral sclerosis (ALS). Adenosine deaminase acting on RNA 2 (ADAR2) specifically catalyzes GluA2 Q/R site-RNA editing. Furthermore, conditional ADAR2 knockout mice (AR2) exhibit a progressive ALS phenotype with TDP-43 pathology in the motor neurons, which is the most reliable pathological marker of ALS...
February 8, 2017: Genes
https://www.readbyqxmd.com/read/28208462/beyond-flory-theory-distribution-functions-for-interacting-lattice-trees
#13
Angelo Rosa, Ralf Everaers
While Flory theories [J. Isaacson and T. C. Lubensky, J. Physique Lett. 41, 469 (1980)JPSLBO0302-072X10.1051/jphyslet:019800041019046900; M. Daoud and J. F. Joanny, J. Physique 42, 1359 (1981)JOPQAG0302-073810.1051/jphys:0198100420100135900; A. M. Gutin et al., Macromolecules 26, 1293 (1993)MAMOBX0024-929710.1021/ma00058a016] provide an extremely useful framework for understanding the behavior of interacting, randomly branching polymers, the approach is inherently limited. Here we use a combination of scaling arguments and computer simulations to go beyond a Gaussian description...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208346/density-of-states-from-mode-expansion-of-the-self-dynamic-structure-factor-of-a-liquid-metal
#14
E Guarini, S Bellissima, U Bafile, E Farhi, A De Francesco, F Formisano, F Barocchi
We show that by exploiting multi-Lorentzian fits of the self-dynamic structure factor at various wave vectors it is possible to carefully perform the Q→0 extrapolation required to determine the spectrum Z(ω) of the velocity autocorrelation function of a liquid. The smooth Q dependence of the fit parameters makes their extrapolation to Q=0 a simple procedure from which Z(ω) becomes computable, with the great advantage of solving the problems related to resolution broadening of either experimental or simulated self-spectra...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208330/heterogeneous-out-of-equilibrium-nonlinear-q-voter-model-with-zealotry
#15
Andrew Mellor, Mauro Mobilia, R K P Zia
We study the dynamics of the out-of-equilibrium nonlinear q-voter model with two types of susceptible voters and zealots, introduced in Mellor et al. [Europhys. Lett. 113, 48001 (2016)EULEEJ0295-507510.1209/0295-5075/113/48001]. In this model, each individual supports one of two parties and is either a susceptible voter of type q_{1} or q_{2}, or is an inflexible zealot. At each time step, a q_{i}-susceptible voter (i=1,2) consults a group of q_{i} neighbors and adopts their opinion if all group members agree, while zealots are inflexible and never change their opinion...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28205402/quantum-chemistry-descriptors-for-photosensitizers-based-on-macrocycles
#16
Fernanda Bettanin, Felipe C T Antonio, Kathia M Honorio, Paula Homem-de-Mello
Phthalocyanines, porphyrins, and chlorins have been widely studied as photosensitizers. Both experimental and computational strategies are employed in order to propose new and more active molecules derived from those macrocycles. In this context, there are two main strategies used: (i) the addition of different substituents and (ii) the complexation of the macrocycle with different metallic ions. In this work, we present selected descriptors based on quantum chemistry calculations for forty macrocycles, including some approved drugs...
February 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28205275/psychometric-evaluation-of-the-youth-eating-disorder-examination-questionnaire-in-children-with-overweight-or-obesity
#17
Andrea E Kass, Kelly Theim Hurst, Rachel P Kolko, Elizabeth B Ruzicka, Richard I Stein, Brian E Saelens, R Robinson Welch, Michael G Perri, Kenneth B Schechtman, Leonard H Epstein, Denise E Wilfley
This study evaluated the psychometric properties of the Youth Eating Disorder Examination Questionnaire (YEDE-Q) and its utility for detecting loss of control (LOC) eating (i.e., eating episodes, regardless of size, involving a perceived inability to control what or how much one is eating) among school-age children with overweight or obesity. Identifying eating pathology, particularly LOC eating, in this population may facilitate treatment that improves weight outcomes and reduces eating disorder risk. Children with overweight or obesity (N = 241; 7-11 years) completed the YEDE-Q and abbreviated Child EDE (ChEDE) to assess LOC eating, prior to entering a weight management treatment trial...
February 15, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28205117/a-randomized-comparison-between-costoclavicular-and-paracoracoid-ultrasound-guided-infraclavicular-block-for-upper-limb-surgery
#18
Prangmalee Leurcharusmee, Maria Francisca Elgueta, Worakamol Tiyaprasertkul, Thitipan Sotthisopha, Artid Samerchua, Aida Gordon, Julian Aliste, Roderick J Finlayson, De Q H Tran
BACKGROUND: This two-centre randomized trial compared costoclavicular and paracoracoid ultrasound-guided infraclavicular brachial plexus block in patients undergoing upper limb surgery. We hypothesized that both techniques would result in similar onset times and designed the study as an equivalence trial. METHODS: Ninety patients undergoing upper limb surgery at or distal to the elbow were randomly allocated to receive a costoclavicular (n = 45) or paracoracoid (n = 45) ultrasound-guided infraclavicular brachial plexus block...
February 15, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28202361/pre-clinical-evaluation-of-voltage-gated-calcium-channel-blockers-derived-from-the-spider-p-nigriventer-in-glioma-progression
#19
Natália Fontana Nicoletti, Thaís Cristina Erig, Rafael Fernandes Zanin, Marcelo Ricardo Roxo, Nelson Pires Ferreira, Marcus Vinicius Gomez, Fernanda Bueno Morrone, Maria Martha Campos
This study investigated the effects of P/Q- and N-type voltage-gated calcium channel (VGCC) blockers derived from P. nigriventer in glioma progression, by means of in vitro and in vivo experiments. Glioma cells M059J, U-138MG and U-251MG were used to evaluate the antiproliferative effects of P/Q- and N-type VGCC inhibitors PhTx3-3 and Phα1β from P. nigriventer (0.3-100 pM), in comparison to MVIIC and MVIIA from C. magus (0.3-100 pM), respectively. The toxins were also analyzed in a glioma model induced by implantation of GL261 mouse cells...
February 12, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28198883/angle-resolved-coherent-wave-mixing-using-a-4%C3%A2-%C3%A2-fs-ultra-broad-bandwidth-laser
#20
I P Mercer, T Witting, T Driver, R J Cogdell, J P Marangos, J W G Tisch
We demonstrate angle-resolved coherent (ARC) wave mixing using 4 fs light pulses derived from a laser source that spans 550-1000 nm. We believe this to be the shortest pulse duration used to date in coherent multi-dimensional spectroscopy. The marriage of this ultra-broad band, few-cycle coherent source with the ARC technique will permit new investigations of the interplay between energy transfers and quantum superposition states spanning 8200  cm<sup>-1</sup>. We applied this configuration to measurements on the photosynthetic low light (LL) complex from Rhodopseudomonas palustris in solution at ambient temperature...
February 15, 2017: Optics Letters
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