keyword
https://read.qxmd.com/read/37722040/cancer-associated-fibroblasts-influence-wnt-pcp-signaling-in-gastric-cancer-cells-by-cytoneme-based-dissemination-of-ror2
#21
JOURNAL ARTICLE
Sally Rogers, Chengting Zhang, Vasilis Anagnostidis, Corin Liddle, Melissa L Fishel, Fabrice Gielen, Steffen Scholpp
Cancer-associated fibroblasts (CAFs) are a crucial component in the tumor microenvironment influencing cancer progression. Besides shaping the extracellular matrix, these fibroblasts provide signaling factors to facilitate tumor survival and alter tumor behavior. In gastric cancer, one crucial signaling pathway influencing invasion and metastasis is the Wnt/Planar Cell Polarity (PCP) signaling. The crucial PCP ligand in this context is WNT5A, which is produced by the CAFs, and gastric cancer cells react upon this signal by enhanced polarized migration...
September 26, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/37552603/ascl1-is-activated-downstream-of-the-ror2-creb-signaling-pathway-to-support-lineage-plasticity-in-prostate-cancer
#22
JOURNAL ARTICLE
Nakisa Tabrizian, Shaghayegh Nouruzi, Cassandra Jingjing Cui, Maxim Kobelev, Takeshi Namekawa, Ishana Lodhia, Amina Talal, Olena Sivak, Dwaipayan Ganguli, Amina Zoubeidi
Lineage plasticity is a form of therapy-induced drug resistance. In prostate cancer, androgen receptor (AR) pathway inhibitors potentially lead to the accretion of tumor relapse with loss of AR signaling and a shift from a luminal state to an alternate program. However, the molecular and signaling mechanisms orchestrating the development of lineage plasticity under the pressure of AR-targeted therapies are not fully understood. Here, a survey of receptor tyrosine kinases (RTKs) identifies ROR2 as the top upregulated RTK following AR pathway inhibition, which feeds into lineage plasticity by promoting stem-cell-like and neuronal networks...
August 7, 2023: Cell Reports
https://read.qxmd.com/read/37430307/extracellular-vesicle-associated-tyrosine-kinase-like-orphan-receptors-ror1-and-ror2-promote-breast-cancer-progression
#23
JOURNAL ARTICLE
Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckmann, Kerstin Menck
BACKGROUND: Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a favorable tumor microenvironment. So far, EV uptake and cargo delivery into target cells have been regarded as the main mechanisms for the pro-tumoral function of EVs. To test this hypothesis, we investigated the fate of the oncogenic transmembrane Wnt tyrosine kinase-like orphan receptor 1 and 2 (ROR1, ROR2) delivered via distinct EV subpopulations to breast cancer cells and aimed to unravel their impact on tumor progression...
July 10, 2023: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/37307827/ror2-related-skeletal-dysplasia-reveals-disrupted-chondrocyte-polarity-through-modulation-of-bmp-tgf-%C3%AE-signaling
#24
JOURNAL ARTICLE
Yichen Yao, Xin Wang, Lichieh Lin, Xiaolei Zhang, Yan Wang
Genetic studies have shown that Robinow syndrome (RS), a rare skeletal dysplasia, is caused by ROR2 mutation. However, the cell origin and molecular mechanisms underlying this disease remain elusive. We established a conditional knockout system by crossing Prx1cre and Osxcre with Ror2 flox/flox mice. and conducted histological and immunofluorescence analyses to investigate the phenotypes during skeletal development. In the Prx1cre line, we observed RS-like skeletal abnormities, including short stature and an arched skull...
June 6, 2023: Aging and Disease
https://read.qxmd.com/read/37199159/ror2-receptor-tyrosine-kinase-like-orphan-receptor-2-planar-cell-polarity-a-new-pathway-controlling-endothelial-cell-polarity-under-flow-conditions
#25
JOURNAL ARTICLE
Pauline Bougaran, Marie-Lise Bats, Valentin Delobel, Sébastien Rubin, Juliette Vaurs, Thierry Couffinhal, Cécile Duplàa, Pascale Dufourcq
BACKGROUND: Endothelial cells (ECs) are sensitive to physical forces created by blood flow, especially to laminar shear stress. Among the cell responses to laminar flow, EC polarization against the flow direction emerges as a key event, particularly during the development and remodeling of the vascular network. EC adopt an elongated planar cell shape with an asymmetrical distribution of intracellular organelles along the axis of blood flow. This study aimed to investigate the involvement of planar cell polarity via the receptor ROR2 (receptor tyrosine kinase-like orphan receptor 2) in endothelial responses to laminar shear stress...
May 18, 2023: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/37156767/genetics-implicates-overactive-osteogenesis-in-the-development-of-diffuse-idiopathic-skeletal-hyperostosis
#26
JOURNAL ARTICLE
Anurag Sethi, J Graham Ruby, Matthew A Veras, Natalie Telis, Eugene Melamud
Diffuse idiopathic skeletal hyperostosis (DISH) is a condition where adjacent vertebrae become fused through formation of osteophytes. The genetic and epidemiological etiology of this condition is not well understood. Here, we implemented a machine learning algorithm to assess the prevalence and severity of the pathology in ~40,000 lateral DXA scans in the UK Biobank Imaging cohort. We find that DISH is highly prevalent, above the age of 45, ~20% of men and ~8% of women having multiple osteophytes. Surprisingly, we find strong phenotypic and genetic association of DISH with increased bone mineral density and content throughout the entire skeletal system...
May 8, 2023: Nature Communications
https://read.qxmd.com/read/37102658/downregulation-of-ror2-attenuates-lps-induced-a549-cell-injury-through-jnk-and-erk-signaling-pathways
#27
JOURNAL ARTICLE
Zhonglin Wang, Liu Yang
BACKGROUND: We aimed to determine whether receptor tyrosine kinase-like orphan receptor 2 (ROR2) is involved in the occurrence of acute lung injury (ALI) by an animal study and explore the effect of ROR2 downregulation on lipopolysaccharide (LPS)-treated human lung carcinoma A549 cells by a cytological study. METHODS: Murine models of ALI were successfully constructed by intratracheal instillation of LPS. Meanwhile, A549 cell line stimulated with LPS was used for a cytological study...
April 2023: Immunity, Inflammation and Disease
https://read.qxmd.com/read/37092468/adipoai-suppresses-osteoclastogenesis-by-activating-adipor1-appl1-an-in-vivo-experimental-study-in-diabetes-associated-peri-implantitis
#28
JOURNAL ARTICLE
Wei Qiu, Zehao Chen, Zhaodan Wang, Yuanting Chen, Kaiqi Luan, Kaiying Zhang, Hongwen Yu, Qisheng Tu, Jake Chen, Hongle Wu, Fuchun Fang
AIM: Diabetics experience severe peri-implant inflammatory bone damage. We aimed to provide powerful evidence supporting the novel adiponectin receptor agonist AdipoAI in treating diabetes-associated peri-implantitis. MATERIALS AND METHODS: Twenty-four ZDF-Leprfa/Crl rats were randomly allocated to three groups (N = 8). After feeding with a high-fat diet to establish diabetic rats, experimental peri-implantitis was induced by implanting titanium rods (1...
April 24, 2023: Clinical Oral Implants Research
https://read.qxmd.com/read/37039156/the-non-canonical-wnt-receptor-ror2-is-required-for-cartilage-cell-polarity-and-morphogenesis-of-the-craniofacial-skeleton-in-zebrafish
#29
JOURNAL ARTICLE
Daniel B Dranow, Pierre Le Pabic, Thomas F Schilling
Non-canonical/β-catenin-independent Wnt signaling plays crucial roles in tissue/cell polarity in epithelia, but its functions have been less well studied in mesenchymal tissues, such as the skeleton. Mutations in non-canonical Wnt signaling pathway genes cause human skeletal diseases such as Robinow syndrome and Brachydactyly Type B1, which disrupt bone growth throughout the endochondral skeleton. Ror2 is one of several non-canonical Wnt receptor/co-receptors. Here, we show that ror2-/- mutant zebrafish have craniofacial skeletal defects, including disruptions of chondrocyte polarity...
April 15, 2023: Development
https://read.qxmd.com/read/37029329/association-of-baseline-ror1-and-ror2-gene-expression-with-clinical-outcomes-in-the-i-spy2-neoadjuvant-breast-cancer-trial
#30
JOURNAL ARTICLE
Barbara A Parker, Rebecca A Shatsky, Richard B Schwab, Anne M Wallace, Denise M Wolf, Gillian L Hirst, Lamorna Brown-Swigart, Laura J Esserman, Laura J van 't Veer, Emanuela M Ghia, Christina Yau, Thomas J Kipps
PURPOSE: ROR1 and ROR2 are Type 1 tyrosine kinase-like orphan receptors for Wnt5a that are associated with breast cancer progression. Experimental agents targeting ROR1 and ROR2 are in clinical trials. This study evaluated whether expression levels of ROR1 or ROR2 correlated with one another or with clinical outcomes. METHODS: We interrogated the clinical significance of high-level gene expression of ROR1 and/or ROR2 in the annotated transcriptome dataset from 989 patients with high-risk early breast cancer enrolled in one of nine completed/graduated/experimental and control arms in the neoadjuvant I-SPY2 clinical trial (NCT01042379)...
April 8, 2023: Breast Cancer Research and Treatment
https://read.qxmd.com/read/37024132/wnt7a-deficit-is-associated-with-dysfunctional-angiogenesis-in-pulmonary-arterial-hypertension
#31
JOURNAL ARTICLE
Ananya Chakraborty, Abinaya Nathan, Mark Orcholski, Stuti Agarwal, Elya A Shamskhou, Natasha Auer, Ankita Mitra, Eleana Stephanie Guardado, Gowri Swaminathan, David F Condon, Joyce Yu, Matthew McCarra, Nicholas H Juul, Alden Mallory, Roberto A Guzman-Hernandez, Ke Yuan, Vanesa Rojas, Joseph T Crossno, Lai-Ming Yung, Paul B Yu, Thomas Spencer, Robert A Winn, Andrea Frump, Vijaya Karoor, Tim Lahm, Haley Hedlin, Jeffrey R Fineman, Robert Lafyatis, Carsten N F Knutsen, Cristina M Alvira, David N Cornfield, Vinicio A de Jesus Perez
INTRODUCTION: Pulmonary arterial hypertension (PAH) is characterized by loss of microvessels. The Wnt pathways control pulmonary angiogenesis, but their role in PAH is incompletely understood. We hypothesized that Wnt activation in pulmonary microvascular endothelial cells (PMVECs) is required for pulmonary angiogenesis, and its loss contributes to PAH. METHODS: Lung tissue and PMVECs from healthy and PAH patients were screened for Wnt production. Global and endothelial-specific Wnt7a-/- mice were generated and exposed to chronic hypoxia and Sugen-hypoxia (SuHx)...
April 6, 2023: European Respiratory Journal
https://read.qxmd.com/read/36974998/retraction-wnt5a-regulates-the-expression-of-ror2-tyrosine-kinase-receptor-in-ovarian-cancer-cells
#32
(no author information available yet)
No abstract text is available yet for this article.
March 28, 2023: Biochemistry and Cell Biology
https://read.qxmd.com/read/36941576/transcriptomic-profiles-of-the-ruminal-wall-in-italian-mediterranean-dairy-buffaloes-fed-green-forage
#33
JOURNAL ARTICLE
Angela Salzano, Salvatore Fioriniello, Nunzia D'Onofrio, Maria Luisa Balestrieri, Riccardo Aiese Cigliano, Gianluca Neglia, Floriana Della Ragione, Giuseppe Campanile
BACKGROUND: Green feed diet in ruminants exerts a beneficial effect on rumen metabolism and enhances the content of milk nutraceutical quality. At present, a comprehensive analysis focused on the identification of genes, and therefore, biological processes modulated by the green feed in buffalo rumen has never been reported. We performed RNA-sequencing in the rumen of buffaloes fed a total mixed ration (TMR) + the inclusion of 30% of ryegrass green feed (treated) or TMR (control), and identified differentially expressed genes (DEGs) using EdgeR and NOISeq tools...
March 20, 2023: BMC Genomics
https://read.qxmd.com/read/36923505/lta4h-extensively-associates-with-mrnas-and-lncrnas-indicative-of-its-novel-regulatory-targets
#34
JOURNAL ARTICLE
Tianjiao Ren, Song Wang, Bo Zhang, Wei Zhou, Cansi Wang, Xiaorui Zhao, Juan Feng
The RNA-binding metabolic enzyme LTA4H is a novel target for cancer chemoprevention and chemotherapy. Recent research shows that the increased expression of LTA4H in laryngeal squamous cell carcinoma (LSCC) promotes tumor proliferation, migration, and metastasis. However, its mechanism remains unclear. To investigate the potential role of LTA4H in LSCC, we employed the improved RNA immunoprecipitation and sequencing (iRIP-Seq) experiment to get the expression profile of LTA4H binding RNA in HeLa model cells, a cancer model cell that is frequently used in molecular mechanism research...
2023: PeerJ
https://read.qxmd.com/read/36704936/noncanonical-wnt-signaling-promotes-colon-tumor-growth-chemoresistance-and-tumor-fibroblast-activation
#35
JOURNAL ARTICLE
Guillem Fuertes, Beatriz Del Valle-Pérez, Javier Pastor, Evelyn Andrades, Raúl Peña, Antonio García de Herreros, Mireia Duñach
Colon tumors of the mesenchymal subtype have the lowest overall survival. Snail1 is essential for the acquisition of this phenotype, characterized by increased tumor stemness and invasion, and high resistance to chemotherapy. Here, we find that Snail1 expression in colon tumor cells is dependent on an autocrine noncanonical Wnt pathway. Accordingly, depletion of Ror2, the co-receptor for noncanonical Wnts such as Wnt5a, potently decreases Snail1 expression. Wnt5a, Ror2, and Snail1 participate in a self-stimulatory feedback loop since Wnt5a increases its own synthesis in a Ror2- and Snail1-dependent fashion...
January 27, 2023: EMBO Reports
https://read.qxmd.com/read/36670115/wnt4-and-ephrinb2-instruct-apical-constriction-via-dishevelled-and-non-canonical-signaling
#36
JOURNAL ARTICLE
Jaeho Yoon, Jian Sun, Moonsup Lee, Yoo-Seok Hwang, Ira O Daar
Apical constriction is a cell shape change critical to vertebrate neural tube closure, and the contractile force required for this process is generated by actin-myosin networks. The signaling cue that instructs this process has remained elusive. Here, we identify Wnt4 and the transmembrane ephrinB2 protein as playing an instructive role in neural tube closure as members of a signaling complex we termed WERDS (Wnt4, EphrinB2, Ror2, Dishevelled (Dsh2), and Shroom3). Disruption of function or interaction among members of the WERDS complex results in defects of apical constriction and neural tube closure...
January 20, 2023: Nature Communications
https://read.qxmd.com/read/36622276/wnt5a-signaling-through-ror2-activates-the-hippo-pathway-to-suppress-yap1-activity-and-tumor-growth
#37
JOURNAL ARTICLE
Keshan Wang, Fen Ma, Seiji Arai, Yun Wang, Andreas Varkaris, Larysa Poluben, Olga Voznesensky, Fang Xie, Xiaoping Zhang, Xin Yuan, Steven P Balk
Noncanonical Wnt signaling by WNT5a has oncogenic and tumor suppressive activities, but downstream pathways mediating these specific effects remain to be fully established. In a subset of prostate cancer organoid culture and xenograft models, inhibition of Wnt synthesis stimulated growth, while WNT5a or a WNT5a mimetic peptide (Foxy5) markedly suppressed tumor growth. WNT5a caused a ROR2-dependent decrease in YAP1 activity that was associated with increased phosphorylation of MST1/2, LATS1, MOB1, and YAP1, indicating Hippo pathway activation...
January 9, 2023: Cancer Research
https://read.qxmd.com/read/36585226/-knockdown-of-receptor-tyrosine-kinase-like-orphan-receptor-2-ror2-inhibits-the-autophagy-of-raw264-7-mouse-macrophages-induced-by-bcg-vaccine
#38
JOURNAL ARTICLE
Xuedi Zheng, Qi Chen, Xueyi Nie, Jia Luo, Jinrui Xu, Yujiong Wang
Objective To investigate the regulation of Wnt5a/receptor tyrosine kinase-like orphan receptor 2 (ROR2) signaling pathway on macrophage autophagy induced by Bacille Calmette Guerin (BCG) infection. Methods RAW264.7 cells were infected with BCG at 0, 2, 6, 12 and 24 hours, and the expressions of Wnt5a, ROR2 and autophagy-related protein microtubule-associated protein 1 light chain 3II (LC3II ) were detected by Western blot analysis. After RAW264.7 cells were treated with ROR2 small interfering RNA and BCG infection respectively or together, the protein expressions of autophagy-related genes 5 (ATG5), P62, beclin-1, ATG7 and LC3II in RAW264...
December 2022: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/36539575/wnt5a-ror2-axis-mediates-vegf-dependence-of-braf-mutant-melanoma
#39
JOURNAL ARTICLE
Nicholas Coupe, Lina Guo, Esther Bridges, Leticia Campo, Olivia Espinosa, Richard Colling, Andrea Marshall, Ashwin Nandakumar, Ruud van Stiphout, Francesca M Buffa, Pippa G Corrie, Mark R Middleton, Valentine M Macaulay
PURPOSE: Despite recent advances, approximately 50% of patient with metastatic melanoma eventually succumb to the disease. Patients with melanomas harboring a BRAF mutation (BRAFMut ) have a worse prognosis than those with wildtype (BRAFWT ) tumors. Unexpectedly, interim AVAST-M Phase III trial data reported benefit from adjuvant anti-VEGF bevacizumab only in the BRAFMut group. We sought to find mechanisms underpinning this sensitivity. METHODS: We investigated this finding in vitro and in vivo using melanoma cell lines and clones generated by BRAFV600E knock-in on a BRAFWT background...
December 21, 2022: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/36506552/real-world-safety-of-pcsk9-inhibitors-a-pharmacovigilance-study-based-on-spontaneous-reports-in-faers
#40
JOURNAL ARTICLE
Zhen Feng, Xiaoye Li, Wai Kei Tong, Qingfeng He, Xiao Zhu, Xiaoqiang Xiang, Zhijia Tang
Objective: We aimed to evaluate alirocumab- and evolocumab-related adverse events (AEs) in real-world compared with all other drugs, overall and by gender and age subgroups; we also aimed to compare their risks of cognitive impairment, musculoskeletal disorders and diabetes with various statins and ezetimibe. Methods: We retrospectively extracted AE reports from the FDA Adverse Event Reporting System (FAERS) database during July 2015-June 2021. Disproportionality analyses were performed using reporting odds ratios (RORs) to detect AE signals of alirocumab and evolocumab in the overall population and in different age and gender subgroups, respectively...
2022: Frontiers in Pharmacology
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