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Isolated splenic sarcoidosis

A Gaudemer, G Sauvet, A Hij, R Stanciu, D Farge-Bancel, J-P Algayres
INTRODUCTION: Splenic localisation of sarcoidosis is common but rare as unique location. We report a case diagnosed by US-guided biopsy. OBSERVATION: A 42-year-old woman presented atypic and recidivant epigastric pain. Abdominal ultrasound showed splenic hypoechoic nodules not characterizable with CT or MRI. PET-CT revealed hypermetabolism without any other abnormal metabolic activity. US-guided biopsy with small needle achieved diagnosis of isolated splenic sarcoidosis...
March 2018: La Revue de Médecine Interne
Moris Sangineto, Chiara Valentina Luglio, Patrizia Suppressa, Carlo Sabbà, Nicola Napoli
Sarcoidosis is a systemic disease characterized by an immune-mediated disorder, which leads to the development of non-caseating granulomas in the involved organs. More than 90% of patients with sarcoidosis present lungs and lymphatic system involvement at onset, while less than 10% has an isolated extrapulmonary localization. Here, we describe the case of an elderly patient with isolated hepato-splenic onset (multiple splenic lesions at imaging and cholestasis), and subsequent pulmonary involvement. The liver biopsy showed the presence of non-caseating granulomas, suggesting sarcoidosis...
December 2017: Auto- Immunity Highlights
Marcial Sebode, Sören Weidemann, Malte Wehmeyer, Ansgar W Lohse, Christoph Schramm
We present a case of hepatosplenic necrotizing sarcoid granulomatosis, a variant form of "classical" sarcoidosis, that became clinically apparent in the form of multiple hepatic and splenic masses mimicking malignancy. Flow cytometry of intrahepatic T cells isolated from liver biopsy led to the targeted treatment with anti-tumor necrosis factor-alpha, which was highly effective in inducing remission. (Hepatology 2017;65:1410-1412).
April 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Chaoyong Tu, Qiaomei Lin, Jingde Zhu, Chuxiao Shao, Kun Zhang, Chuan Jiang, Zhiyong Ding, Xingmu Zhou, Jiefei Tu, Wanlin Zhu, Wei Chen
Sarcoidosis is a multisystemic disease of unknown origin characterized by the formation of non-caseating granulomas. Thoracic involvement is the most common presentation; however, sarcoidosis can involve almost any other organ. To the best of our knowledge there have been only 10 cases of splenic sarcoidosis reported in the English literature, with no reports of sarcoidosis of an accessory spleen. The present study reports a case of isolated sarcoidosis of an accessory spleen in the greater omentum, which was identified postoperatively in a 44-year-old female...
June 2016: Experimental and Therapeutic Medicine
K P Sreelesh, M L Arun Kumar, T M Anoop
Here we report a case of primary splenic sarcoidosis presenting with isolated splenomegaly with multiple splenic nodules. The sarcoidosis was diagnosed and treated by splenectomy.
October 2014: Proceedings of the Baylor University Medical Center
Marcelo Martins Souto, Bruna Cogo Tempes, Bruna Franco Lambert, Eduardo Neubarth Trindade, Manoel Roberto Maciel Trindade
INTRODUCTION: Sarcoidosis is an inflammatory disease with an unknown etiology. The pulmonary interstitium is mainly involved, with noncaseating granulomas and lymphadenopathy. It is a multisystemic disease, and the differential diagnosis should include infectious, neoplastic, and autoimmune diseases to prevent inappropriate treatment and unnecessary surgery. Abdominal disease without evidence of pulmonary abnormalities on chest radiography in sarcoidosis can be found in approximately 25% to 38% of cases...
January 2014: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Antonio Ruiz Serrato, M Ángeles Guerrero León, Juan Jiménez Martín, Desirée Gómez Lora
No abstract text is available yet for this article.
January 2015: Reumatología Clinica
Salem Bauones, Thomas Le Corroller, Olivier Durieux, Daphné Guenoun, Jean Del Grande, Nicolas Pirro, Pierre Champsaur
Sarcoidosis is a multisystem granulomatous disease of unknown cause that commonly involves the spleen. Sarcoid can produce either homogeneous splenomegaly or multiple splenic nodules. Although other organ system involvement usually occurs, this is not invariable. Herein, we report on the clinical, histological, and radiological features-including sonography and MRI-of an isolated splenic sarcoidosis that mimicked neoplastic disease in a 37-year-old female. Knowledge of this atypical sonographic presentation may prevent unnecessary splenectomy...
January 2014: Journal of Clinical Ultrasound: JCU
Yuiko Ogiwara, Seijiro Mori, Mizuki Iwama, Motoji Sawabe, Nobuo Kanazawa, Hikaru Furuta, Yoshiyuki Kimbara, Yoshiaki Tamura, Atsushi Araki, Hideki Ito
No abstract text is available yet for this article.
November 10, 2009: Nihon Naika Gakkai Zasshi. the Journal of the Japanese Society of Internal Medicine
Huan-Lun Hsu
No abstract text is available yet for this article.
January 2011: Gastroenterology
Yuiko Ogiwara, Seijiro Mori, Mizuki Iwama, Motoji Sawabe, Minoru Takemoto, Nobuo Kanazawa, Koh Furuta, Izumi Fukuda, Yoshitaka Kondo, Yoshiyuki Kimbara, Yoshiaki Tamura, Yuko Chiba, Atsushi Araki, Koutaro Yokote, Naoki Maruyama, Hideki Ito
Hypoglycemia is reported to be one of the manifestations of a patient with hypothalamic sarcoid infiltrates due to impaired counter-regulation of glucose. But, without hypothalamic lesion, patients with sarcoidosis would not be expected to have hypoglycemia. We recently identified a patient with an isolated sarcoidosis of the spleen who had experienced frequent fasting hypoglycemia which completely disappeared after splenectomy. During hypoglycemia, serum insulin was undetectable. Endocrinological examination revealed no abnormality...
2010: Endocrine Journal
C Jöst, C Aiginger, H Prosch
No abstract text is available yet for this article.
April 2010: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
M Giovinale, C Fonnesu, A Soriano, C Cerquaglia, V Curigliano, E Verrecchia, G De Socio, G Gasbarrini, R Manna
Sarcoidosis is a granulomatous disease of unknown origin, with pulmonary findings in more than 90% of patients. Extrapulmonary involvement is common and all organs can be involved (especially lymph nodes, eyes, joints, central nervous system) but it is rare to find an isolated extrapulmonary disease (less than 10% of patients). Granulomatous inflammation of the spleen and the liver is common in patients with systemic sarcoidosis, while hepatosplenic enlargement is unusual and splenic involvement rare. We report two cases of systemic sarcoidosis, that onset with splenic and hepatosplenic disease, and one case with splenic sarcoidosis without pulmonary involvement...
March 2009: European Review for Medical and Pharmacological Sciences
Sandeep P Joglekar, Robert L Hudson, Rajesh Logasundaram, Jerome H Pereira
BACKGROUND: Sarcoidosis is a granulomatous disease of unknown aetiology. Over 90% patients of sarcoidosis present with pulmonary findings. Other organs such as lymph nodes, skin, and joints may be involved. Isolated granulomatous disease confined to the spleen is rare. CASE PRESENTATION: This report documents a rare case of isolated granulomatous disease of spleen presenting as hypercalcemia. After all possible causes for hypercalcemia were ruled out, splenectomy was done which proved diagnostic and therapeutic, as calcium levels returned to normal...
2009: World Journal of Surgical Oncology
Dariusz Woszczyk, Aleksandra Kołodziej-Jaskuła, Joanna Mykała-Cieśla, Anna Bal, Krzysztof Łabuzek, Teresa Gasińska
BACKGROUND: Ultrasonography (US) is an easy and non-invasive technique of visualizing spleen. Thanks to its repeatability, it plays an important role in the diagnostics of, among others, developmental anomalies, such as supernumerary or lobated spleens, as well as focal lesions. It is also used in monitoring the size of the spleen and it considerably facilitates diagnosis after certain injuries. Thanks to the application of the Doppler method, it also facilitates the diagnostics of pathologies within the spleen's vessels...
August 2006: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Hasan Zia, Harry Zemon, Fredrick Brody
Sarcoidosis is a granulomatous disease of unknown etiology. Over 90% of patients with sarcoidosis present with pulmonary findings at the time of diagnosis. Extrapulmonary involvement is common, including the liver, eyes, central nervous system, lymph nodes, and joints. However, isolated granulomatous disease confined to the spleen is rare. This report documents a rare case of isolated granulomatous disease of the spleen diagnosed and treated laparoscopically. A 47-year-old female presented to her internist with nausea and mild epigastric abdominal pain...
April 2005: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
M Molina, G Ortega, M D Rivera, R Pérez-Luján
Isolated extrathoracic sarcoidosis is a rare entity. We present a 25-year old woman with recurrent episodes of fever of unknown origin in the 10 years previously, with a new episode of fever with hepatosplenomegaly, abdominal adenopathies and cranial osteolysis without pulmonary or mediastinal affectation. With the suspicion of linfoproliferative disease we have resected the spleen with a weight of 1500 g. and multiple non caseous granulomata also in the liver and adenopathies. The clinical presentation is compatible with an atypical sarcoidosis without thoracic affectation and with two rare associated clinical manifestation namely giant splenomegaly and sarcoidosis of the skull...
December 1996: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
G Nickenig, Y Ko, C Wanning, H Müller-Miny, K Zhou, H Vetter
No abstract text is available yet for this article.
June 1996: Der Internist
H Berndt
No abstract text is available yet for this article.
December 12, 1993: Zeitschrift Für ärztliche Fortbildung
M Kitamura, T Ishizaki
Although liver and/or spleen sarcoidosis usually shows no symptoms and subtle elevated levels of liver enzymes, diagnostic image scanning methods (abdominal ultrasonic scan, computed tomographic scan, magnetic resonance image, and Ga and Tc scintiscan) can easily detect the lesion. Laparoscopy unveils isolated scattered sarcoid nodules on the surface of the liver and/or spleen and biopsied specimen reveal a non-caseating epithelioid granuloma containing multinucleated giant cells especially in the portal area...
June 1994: Nihon Rinsho. Japanese Journal of Clinical Medicine
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