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X linked agammaglobulinaemia

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https://www.readbyqxmd.com/read/27692490/-primary-immunodeficiencies-in-seriously-ill-children-report-of-3-clinical-cases
#1
Leticia Yañez, Pamela Lama, Carolina Rivacoba, Juanita Zamorano, Maria Angélica Marinovic
: Primary immunodeficiency diseases (PID) are congenital disorders secondary to an impaired immune response. Infections, autoimmune disorders, atopy, and lymphoproliferative syndromes are commonly associated with this disorder. OBJECTIVE: To present and discuss 3 infants diagnosed with PID. CLINICAL CASES: The cases are presented of three patients with PID diagnosed during their first admission to a Paediatric Intensive Critical Care Unit...
September 27, 2016: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/27535475/x-linked-agammaglobulinaemia-xla-presenting-with-neutropenia-and-pseudomonas-aeruginosa-cellulitis
#2
J M MacMahon, M Ni Chroinin, J Hourihane, T R Leahy
No abstract text is available yet for this article.
August 17, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27377098/recurrent-cellulitis-caused-by-helicobacter-cinaedi-in-a-patient-with-x-linked-agammaglobulinaemia
#3
Masayo Sugimoto, Takuya Takeichi, Hideki Muramatsu, Daiei Kojima, Yukari Osada, Michihiro Kono, Seiji Kojima, Masashi Akiyama
is missing (Short communication).
July 5, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/26183722/higher-cardiovascular-risk-in-common-variable-immunodeficiency-and-x-linked-agammaglobulinaemia-patients
#4
Daniele Gonçalves Vieira, Beatriz Tavares Costa-Carvalho, Sonia Hix, Rosangela da Silva, Milena S G Correia, Roseli Oselka Saccardo Sarni
INTRODUCTION: Common variable immunodeficiency and X-linked agammaglobulinaemia are primary immunodeficiencies classified as antibody deficiencies, and they both result in hypogammaglobulinaemia. OBJECTIVE: Evaluate the lipid profile and other cardiovascular risk biomarkers in CVID and XLA patients. METHODS: In total, 24 patients and 12 healthy controls matched by age and gender were included in the study. We evaluated anthropometric measurements, and seric total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apo A-I, small dense LDL (sdLDL), C-reactive protein (CRP), and tumour necrosis factor alpha (TNF-alpha), myeloperoxidase (MPO), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) were assessed...
2015: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/25091287/a-novel-treatment-in-x-linked-agammaglobulinaemia-hyperbaric-oxygen-therapy-in-refractory-chronic-wounds
#5
C L Steele, C Cridge, J D M Edgar
Chronic wounds are a rare complication of X-linked agammaglobulinaemia (XLA). Fastidious organisms such as helicobacter bills have been reported in XLA with chronic wounds but sterile chronic wounds also occur. Hyperbaric Oxygen Therapy has been used in chronic wounds but has not previously been reported in primary antibody deficiencies. We present a case of a chronic wound in a patient with XLA refractory to antimicrobial therapy that made a remarkable recovery following Hyperbaric Oxygen Therapy.
October 2014: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/24992401/the-use-of-infliximab-in-x-linked-agammaglobulinaemia-associated-enteropathy
#6
REVIEW
P T Davey, C J Tan, K Gardiner
Granulomatous small bowel enteropathy is an unusual presentation associated with X-linked agammaglobulinaemia. We present a rare case of this condition that was further complicated by an enterocutaneous fistula and report our experience managing this condition successfully with infliximab, which has not been documented in the literature previously.
July 2014: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/24506305/the-pedpad-study-boys-predominate-in-the-hypogammaglobulinaemia-registry-of-the-esid-online-database
#7
E J H Schatorjé, B Gathmann, R W N M van Hout, E de Vries
Hypogammaglobulinaemias are the most common primary immunodeficiency diseases. This group of diseases is very heterogeneous, and little is known about these diseases in children. In the Pediatric Predominantly Antibody Deficiencies (PedPAD) study, we analysed data from the European Society for Immunodeficiencies (ESID) online database to gain more insight into the characteristics of children with hypogammaglobulinaemia; 46 centres in 18 different countries agreed to participate. Data from 2076 of the 3191 children who were registered at the time of data extraction with a diagnosis of hypogammaglobulinaemia (this excludes agammaglobulinaemia and defects in class-switch recombination) were available for analysis...
June 2014: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24485939/mortality-and-morbidity-in-patients-with-x-linked-agammaglobulinaemia
#8
H Abolhassani, A Hirbod-Mobarakeh, S Shahinpour, M Panahi, P Mohammadinejad, B Mirminachi, M S Shakari, B Samavat, A Aghamohammadi
BACKGROUND: X-linked agammaglobulinaemia (XLA) is a genetic disorder characterised by a defect in the generation of mature B cells, lack of antibodies production, and susceptibility to recurrent bacterial infections. Understanding of the risk factors responsible for morbidity and mortality in these patients can help in a better management of this disorder. However, there is a lack of specific studies in the literature regarding the morbidity and mortality of XLA patients. This study is designed to evaluate morbidities and mortality and survival rates in Iranian patients with XLA diagnosis during the past 20 years...
January 2015: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/24485938/bronchial-hyperreactivity-in-children-with-antibody-deficiencies
#9
Celal Özcan, Ayşe Metin, Mustafa Erkoçoğlu, Can Naci Kocabas
BACKGROUND: Antibody deficiency comprises a heterogeneous group of disorders characterised by the body's inability to mount an effective antibody response to pathogens. Although it has been reported that asthma and allergic disease are frequent in antibody deficiencies, there are no data that evaluate and compare bronchial hyperreactivity (BHR) in all groups of antibody deficiencies. In this study, we aimed to evaluate and compare the frequency of BHR in patients with different antibody deficiencies...
January 2015: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/24338563/modeling-primary-immunodeficiency-disease-epidemiology-and-its-treatment-to-estimate-latent-therapeutic-demand-for-immunoglobulin
#10
Jeffrey S Stonebraker, Albert Farrugia, Benjamin Gathmann, Jordan S Orange
PURPOSE: Estimating the underlying demand for immunoglobulin (Ig) is important to ensure that adequate provision is made for patients with primary immune deficiency (PID) in the context of the competing demands for Ig and to ensure optimal therapeutic regimens. The concept of latent therapeutic demand (LTD) was used to estimate evidence-based requirements and compared to the actual Ig consumption in different countries. The estimates were performed for common variable immunodeficiency (CVID) and X-linked Agammaglobulinaemia (XLA), the two most commonly studied PIDs using Ig...
February 2014: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/24074005/atypical-x-linked-agammaglobulinaemia-caused-by-a-novel-btk-mutation-in-a-selective-immunoglobulin-m-deficiency-patient
#11
Lee-Moay Lim, Jer-Ming Chang, I-Fang Wang, Wei-Chiao Chang, Daw-Yang Hwang, Hung-Chun Chen
BACKGROUND: X-linked agammaglobulinaemia (XLA) is the most common inherited humoural immunodeficiency disorder. Mutations in the gene coding for Bruton's tyrosine kinase (BTK) have been identified as the cause of XLA. Most affected patients exhibit a marked reduction of serum immunoglobulins, mature B cells, and an increased susceptibility to recurrent bacterial infections. However, the diagnosis of XLA can be a challenge in certain patients who have near-normal levels of serum immunoglobulin...
September 27, 2013: BMC Pediatrics
https://www.readbyqxmd.com/read/23549506/x-linked-agammaglobulinemia-caused-by-new-mutation-in-btk-gene-a-case-report
#12
Zuzana Havlicekova, Milos Jesenak, Tomas Freiberger, Peter Banovcin
AIM: Primary immunodeficiencies (PID) are becoming a recognized public health problem worldwide. The most important subgroup of these disorders are the antibody deficiencies. X-linked agammaglobulinaemia was the first described entity of this group and is characterised by early onset of recurrent bacterial infections, profound deficiency of all immunoglobulin isotypes and markedly reduced number of peripheral B-lymphocytes. CASE REPORT: We report the case of a 10-year old boy with X-linked agammaglobulinaemia caused by a previously non-described mutation in BTK gene with typical clinical presentation but delayed diagnosis...
September 2014: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/23108220/guidelines-for-newborn-screening-of-primary-immunodeficiency-diseases
#13
REVIEW
Stephan Borte, Ulrika von Döbeln, Lennart Hammarström
PURPOSE OF REVIEW: Technical possibilities to screen for inborn errors of immune function at the neonatal stage have been rapidly progressing, whereas the guidelines that apply for the evaluation of benefits and concerns on expanding screening panels have not been broadly discussed for primary immunodeficiency diseases (PID). This review reflects on the assessment of severe combined immunodeficiencies (SCID), primary agammaglobulinaemias (such as X-linked agammaglobulinaemia) and inherited haemophagocytic syndromes (such as familial haemophagocytic lymphohistiocytosis) to be included in newborn screening (NBS) programmes...
January 2013: Current Opinion in Hematology
https://www.readbyqxmd.com/read/23039891/t-cell-phenotypes-in-patients-with-common-variable-immunodeficiency-disorders-associations-with-clinical-phenotypes-in-comparison-with-other-groups-with-recurrent-infections
#14
COMPARATIVE STUDY
E A L Bateman, L Ayers, R Sadler, M Lucas, C Roberts, A Woods, K Packwood, J Burden, D Harrison, N Kaenzig, M Lee, H M Chapel, B L Ferry
Common variable immunodeficiency disorders (CVID) are a group of heterogeneous conditions that have in common primary failure of B cell function, although numerous T cell abnormalities have been described, including reduced proliferative response and reduced regulatory T cells. This study compared the T cell phenotype of CVID patients subdivided into clinical phenotypes as well as patients with partial antibody deficiencies [immunoglobulin (Ig)G subclass deficiency and selective IgA deficiency], X-linked agammaglobulinaemia (XLA) and healthy and disease controls...
November 2012: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/22442492/the-gene-involved-in-x-linked-agammaglobulinaemia-is-a-member-of-the-src-family-of-protein-tyrosine-kinases-1993
#15
David Vetrie, Igor Vořechovský, Paschalis Sideras, Jill Holland, Angela Davies, Frances Flinter, Lennart Hammarström, Christine Kinnon, Roland Levinsky, Martin Bobrow, C I Edvard Smith, David R Bentley
No abstract text is available yet for this article.
April 1, 2012: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/22439627/pyoderma-gangrenosum-like-ulcer-caused-by-helicobacter-cinaedi-in-a-patient-with-x-linked-agammaglobulinaemia
#16
J Dua, E Elliot, P Bright, S Grigoriadou, R Bull, M Millar, N Wijesuriya, H J Longhurst
Cutaneous lesions of the legs have been linked to Helicobacter species in a number of patients with X-linked agammaglobulinaemia (XLA), a primary immunodeficiency. We describe a 26-year-old patient with XLA, who was referred with an extensive skin ulcer that enlarged gradually over the course of 7 years. The ulcer resembled pyoderma gangrenosum (PG), and extended from below the knee to the ankle. The man (who has sex with men) was negative for human immunodeficiency virus. Helicobacter cinaedi was identified by 16S ribosomal (r)DNA PCR analysis from a biopsy of the lesion...
August 2012: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/21893448/-antibody-deficiencies-a-survey-from-three-clinical-immunology-centers-for-adults-in-buenos-aires-city
#17
Diego S Fernández Romero, María Cecilia Juri, María Virginia Paolini, Alejandro Malbrán
Antibody deficiency (AD) comprises a group of diseases characterized by the inability to develop an effective antibody mediated immune response. These patients suffer mainly of encapsulated extracellular bacterial infections of the respiratory tract. The aim of our study was to describe the clinical characteristics of 128 patients with suspected or confirmed AD who were referred to 3 immunodeficiency centers for adults, from June 2004 to December 2009. Three of these patients (2.3%) consulted for recurrent infections only once, without sufficient data for a proper classification, and were excluded...
2011: Medicina
https://www.readbyqxmd.com/read/21553933/pharmacokinetics-of-subcutaneous-igpro20-in-patients-with-primary-immunodeficiency
#18
MULTICENTER STUDY
Richard L Wasserman, Isaac Melamed, Robert P Nelson, Alan P Knutsen, Mary Beth Fasano, Mark R Stein, Mikhail A Rojavin, Joseph A Church
BACKGROUND AND OBJECTIVES: Immunoglobulin replacement is a standard therapy for patients with primary immunodeficiencies. Subcutaneous administration of immunoglobulin offers more constant IgG levels than intravenous administration and simplifies administration for some patients. Use of L-proline as an excipient contributes to the stability of highly concentrated IgG preparations. The aims of the present study were to evaluate the pharmacokinetics of IgPro20 (Hizentra®), a new 20% subcutaneous IgG solution, and compare the area under the serum concentration-time curve (AUC) with that of a similar intravenous 10% IgG solution (IgPro10; Privigen®)...
June 2011: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/21488866/importance-of-b-cell-co-stimulation-in-cd4-t-cell-differentiation-x-linked-agammaglobulinaemia-a-human-model
#19
COMPARATIVE STUDY
H Martini, V Enright, M Perro, S Workman, J Birmelin, E Giorda, I Quinti, V Lougaris, M Baronio, K Warnatz, B Grimbacher
We were interested in the question of whether the congenital lack of B cells actually had any influence on the development of the T cell compartment in patients with agammaglobulinaemia. Sixteen patients with X-linked agammaglobulinaemia (XLA) due to mutations in Btk, nine patients affected by common variable immune deficiency (CVID) with <2% of peripheral B cells and 20 healthy volunteers were enrolled. The T cell phenotype was determined with FACSCalibur and CellQuest Pro software. Mann-Whitney two-tailed analysis was used for statistical analysis...
June 2011: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/21466546/autoimmunity-in-primary-immune-deficiency-taking-lessons-from-our-patients
#20
REVIEW
C Cunningham-Rundles
The elucidation of the genes leading to selected immune defects has accelerated our understanding of the molecular basis of tolerance in autoimmunity disorders. Mutations in genes of the immune system are known to lead to a catalogue of functional deficits, including loss of activation-induced Fas-mediated apoptosis, an inability to remove self-reactive T and/or B cells and insufficient numbers or functions of regulatory T cells. In most cases, microbial antigen stimulation occurs simultaneously, leading to further inflammatory responses...
June 2011: Clinical and Experimental Immunology
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