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https://www.readbyqxmd.com/read/27903467/arterio-cutaneous-fistula-associated-with-bilateral-femoral-pseudoaneurysms-caused-by-bacillus-calmette-gu%C3%A3-rin-apropos-of-a-case-and-review-of-literature
#1
Álvaro Torres-Blanco, Francisco Gómez-Palonés, Gemma Edo-Fleta
Vascular complications of intravesical instillation of bacillus Calmette-Guérin (BCG) are rare. BCG is an attenuated strain of Mycobacterium bovis (M. Bovis) that was initially developed for vaccination against tuberculosis, but it has also been used as an adjuvant treatment for bladder transitional carcinoma. We report a patient with a history of instillation of BCG two years before, who underwent surgical treatment of 2 pseudoaneurysms. The first, located in the left superficial femoral artery (SFA), was resected and the artery was ligated because he had a history of femoropopliteal occlusion...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27893793/field-trial-of-an-aerially-distributed-tuberculosis-vaccine-in-a-low-density-wildlife-population-of-brushtail-possums-trichosurus-vulpecula
#2
Graham Nugent, Ivor J Yockney, E Jackie Whitford, Martin L Cross, Frank E Aldwell, Bryce M Buddle
Oral-delivery Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine in a lipid matrix has been shown to confer protection against M. bovis infection and reduce the severity of tuberculosis (TB) when fed to brushtail possums (Trichosurus vulpecula), the major wildlife vector of bovine TB in New Zealand. Here we demonstrate the feasibility of aerial delivery of this live vaccine in bait form to an M. bovis-infected wild possum population, and subsequently assess vaccine uptake and field efficacy. Pre-trial studies indicated a resident possum population at very low density (<0...
2016: PloS One
https://www.readbyqxmd.com/read/27879332/mucosal-bcg-vaccination-induces-protective-lung-resident-memory-t-cell-populations-against-tuberculosis
#3
Carolina Perdomo, Ulrike Zedler, Anja A Kühl, Laura Lozza, Philippe Saikali, Leif E Sander, Alexis Vogelzang, Stefan H E Kaufmann, Andreas Kupz
: Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB), yet its moderate efficacy against pulmonary TB calls for improved vaccination strategies. Mucosal BCG vaccination generates superior protection against TB in animal models; however, the mechanisms of protection remain elusive. Tissue-resident memory T (TRM) cells have been implicated in protective immune responses against viral infections, but the role of TRM cells following mycobacterial infection is unknown...
November 22, 2016: MBio
https://www.readbyqxmd.com/read/27872739/30-years-retrospective-review-of-tuberculosis-cases-in-a-tuberculosis-dispensary-in-bursa-nilufer-turkey-1985-2014-changes-of-epidemics
#4
Kayıhan Pala, Harika Gerçek, Tuncay Aydin Taş, Rukiye Çakir, Sedef Özgüç, Timur Yildiz
OBJECTIVE: The aim of this study is to describe the epidemiological and clinical aspects of patients who applied to the Bursa Nilufer Tuberculosis Dispensary by investigating the trends in epidemics over three decades. METHOD: In this retrospective observational study, the records of all tuberculosis cases (1630 patients) treated in the last 30 years (1985-2014) at the Bursa Nilufer Tuberculosis Dispensary were examined and statistically analyzed. RESULTS: Males comprised 65...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27871308/recruiting-to-clinical-trials-on-the-telephone-a-randomized-controlled-trial
#5
Kim Thestrup Foss, Jesper Kjærgaard, Lone Graff Stensballe, Gorm Greisen
BACKGROUND: Informed consent is an essential element of clinical research. Obtaining consent, however, may be challenging. The use of the telephone for giving information and obtaining consent may be practical but little formal research has been done. METHODS: We examined the use of the telephone for the purpose of informing expectant mothers about The Danish Calmette Study; a randomized clinical trial assessing neonatal Bacille Calmette-Guérin vaccination. Expectant mothers received an invitation letter with a Participant Information Sheet about The Danish Calmette Study, the present trial, and a Consent Form...
November 21, 2016: Trials
https://www.readbyqxmd.com/read/27865396/mycobacterium-smegmatis-proteoliposome-induce-protection-in-a-murine-progressive-pulmonary-tuberculosis-model
#6
Yanely Tirado, Alina Puig, Nadine Alvarez, Reinier Borrero, Alicia Aguilar, Frank Camacho, Fatima Reyes, Sonsire Fernandez, Jose Luis Perez, Reynaldo Acevedo, Dulce Mata Espinoza, Jorge Alberto Barrios Payan, Maria de Los A Garcia, Ramlah Kadir, María E Sarmiento, Rogelio Hernandez-Pando, Mohd-Nor Norazmi, Armando Acosta
Tuberculosis (TB) remains an important cause of mortality and morbidity. The TB vaccine, BCG, is not fully protective against the adult form of the disease and is unable to prevent its transmission although it is still useful against severe childhood TB. Hence, the search for new vaccines is of great interest. In a previous study, we have shown that proteoliposomes obtained from Mycobacterium smegmatis (PLMs) induced cross reactive humoral and cellular response against Mycobacterium tuberculosis (Mtb) antigens...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865390/alternative-bcg-delivery-strategies-improve-protection-against-mycobacterium-tuberculosis-in-non-human-primates-protection-associated-with-mycobacterial-antigen-specific-cd4-effector-memory-t-cell-populations
#7
S Sharpe, A White, C Sarfas, L Sibley, F Gleeson, A McIntyre, R Basaraba, S Clark, G Hall, E Rayner, A Williams, P D Marsh, M Dennis
Intradermal (ID) BCG injection provides incomplete protection against TB in humans and experimental models. Alternative BCG vaccination strategies may improve protection in model species, including rhesus macaques. This study compares the immunogenicity and efficacy of BCG administered by ID and intravenous (IV) injection, or as an intratracheal mucosal boost (ID + IT), against aerosol challenge with Mycobacterium tuberculosis Erdman strain. Disease pathology was significantly reduced, and survival improved, by each BCG vaccination strategy, relative to unvaccinated animals...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865389/mycobacterium-indicus-pranii-as-a-booster-vaccine-enhances-bcg-induced-immunity-and-confers-higher-protection-in-animal-models-of-tuberculosis
#8
Mohd Saqib, Rahul Khatri, Bindu Singh, Ananya Gupta, Arvind Kumar, Sangeeta Bhaskar
BCG, the only approved vaccine protects against severe form of childhood tuberculosis but its protective efficacy wanes in adolescence. BCG has reduced the incidence of infant TB considerably in endemic areas; therefore prime-boost strategy is the most realistic measure for control of tuberculosis in near future. Mycobacterium indicus pranii (MIP) shares significant antigenic repertoire with Mtb and BCG and has been shown to impart significant protection in animal models of tuberculosis. In this study, MIP was given as a booster to BCG vaccine which enhanced the BCG mediated immune response, resulting in higher protection...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865381/the-impact-of-bacille-calmette-gu%C3%A3-rin-shortage-on-immunisation-practice-and-policies-in-europe-a-paediatric-tuberculosis-network-european-trials-group-ptbnet-survey
#9
Antti Kontturi, Begoña Santiago, Marc Tebruegge, Ulrich von Both, Eeva Salo, Nicole Ritz
BACKGROUND: Recent reports indicate an ongoing BCG shortage that may influence immunisation practice. This study aimed to determine current availability of BCG vaccine across Europe, and implications on immunisation practices and policies in Europe. METHODS: Web-based survey among Paediatric Tuberculosis Network European Trials Group (ptbnet) members, between May and October 2015. RESULTS: Twenty individuals from 13 European countries participated...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27863623/tuberculous-lymphadenitis-of-the-head-and-neck-in-canadian-children-experience-from-a-low-burden-region
#10
Jason J Xu, Shazia Peer, Blake C Papsin, Ian Kitai, Evan J Propst
BACKGROUND: Children are more likely than adults to develop extra-pulmonary tuberculosis (EPTB), which often presents as cervical lymphadenopathy. The role of surgery in management is uncertain. We reviewed all head and neck EPTB cases presenting to our tertiary care pediatric institution over a twelve-year period. METHODS: All children 18 years of age and younger with EPTB involving the head and neck were included. We recorded clinical data and age at diagnosis, birth country, BCG vaccination status, as well as radiographic, surgical, histological, and microbiological results...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27856947/is-diphtheria-tetanus-pertussis-dtp-associated-with-increased-female-mortality-a-meta-analysis-testing-the-hypotheses-of-sex-differential-non-specific-effects-of-dtp-vaccine
#11
Peter Aaby, Henrik Ravn, Ane B Fisker, Amabelia Rodrigues, Christine S Benn
BACKGROUND: Ten years ago, we formulated two hypotheses about whole-cell diphtheria-tetanus-pertussis (DTP) vaccination: first, when given after BCG, DTP increases mortality in girls and, second, following DTP there is an increase in the female/male mortality rate ratio (MRR). A recent review by WHO found no convincing evidence that DTP increases mortality in females. METHODS: We used previous DTP reviews as well as the recent WHO review for assessing the hypotheses...
November 17, 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27847173/enhanced-protective-efficacy-against-tuberculosis-provided-by-a-recombinant-urease-deficient-bcg-expressing-heat-shock-protein-70-major-membrane-protein-ii-having-pest-sequence
#12
Yumiko Tsukamoto, Yumi Maeda, Toshiki Tamura, Tetsu Mukai, Satoshi Mitarai, Saburo Yamamoto, Masahiko Makino
Enhancement of the T cell-stimulating ability of Mycobacterium bovis BCG (BCG) is necessary to develop an effective tuberculosis vaccine. For this purpose, we introduced the PEST-HSP70-major membrane protein-II (MMPII)-PEST fusion gene into ureC-gene depleted recombinant (r) BCG to produce BCG-PEST. The PEST sequence is involved in the proteasomal processing of antigens. BCG-PEST secreted the PEST-HSP70-MMPII-PEST fusion protein and more efficiently activated human monocyte-derived dendritic cells (DCs) in terms of phenotypic changes and cytokine productions than an empty-vector-introduced BCG or HSP70-MMPII gene-introduced ureC gene-depleted BCG (BCG-DHTM)...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27843162/estimation-of-child-vaccination-coverage-at-state-and-national-levels-in-india
#13
Pankaj Bhatnagar, Satish Gupta, Rakesh Kumar, Pradeep Haldar, Raman Sethi, Sunil Bahl
OBJECTIVE: To review the data, for 1999-2013, on state-level child vaccination coverage in India and provide estimates of coverage at state and national levels. METHODS: We collated data from administrative reports, population-based surveys and other sources and used them to produce annual estimates of vaccination coverage. We investigated bacille Calmette-Guérin vaccine, the first and third doses of vaccine against diphtheria, tetanus and pertussis, the third dose of oral polio vaccine and the first dose of vaccine against measles...
October 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27833923/low-dose-bcg-infection-as-a-model-for-macrophage-activation-maintaining-cell-viability
#14
Leslie Chávez-Galán, Dominique Vesin, Denis Martinvalet, Irene Garcia
Mycobacterium bovis BCG, the current vaccine against tuberculosis, is ingested by macrophages promoting the development of effector functions including cell death and microbicidal mechanisms. Despite accumulating reports on M. tuberculosis, mechanisms of BCG/macrophage interaction remain relatively undefined. In vivo, few bacilli are sufficient to establish a mycobacterial infection; however, in vitro studies systematically use high mycobacterium doses. In this study, we analyze macrophage/BCG interactions and microenvironment upon infection with low BCG doses and propose an in vitro model to study cell activation without affecting viability...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27823900/gene-based-neonatal-immune-priming-potentiates-a-mucosal-adenoviral-vaccine-encoding-mycobacterial-ag85b
#15
Guixiang Dai, Hamada F Rady, Weitao Huang, Judd E Shellito, Carol Mason, Alistair J Ramsay
Tuberculosis remains a major public health hazard worldwide, with neonates and young infants potentially more susceptible to infection than adults. BCG, the only vaccine currently available, provides some protection against tuberculous meningitis in children but variable efficacy in adults, and is not safe to use in immune compromised individuals. A safe and effective vaccine that could be given early in life, and that could also potentiate subsequent booster immunization, would represent a significant advance...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27821882/inequalities-in-full-immunization-coverage-trends-in-low-and-middle-income-countries
#16
María Clara Restrepo-Méndez, Aluísio Jd Barros, Kerry Lm Wong, Hope L Johnson, George Pariyo, Giovanny Va França, Fernando C Wehrmeister, Cesar G Victora
OBJECTIVE: To investigate disparities in full immunization coverage across and within 86 low- and middle-income countries. METHODS: In May 2015, using data from the most recent Demographic and Health Surveys and Multiple Indicator Cluster Surveys, we investigated inequalities in full immunization coverage - i.e. one dose of bacille Calmette-Guérin vaccine, one dose of measles vaccine, three doses of vaccine against diphtheria, pertussis and tetanus and three doses of polio vaccine - in 86 low- or middle-income countries...
November 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27818362/impact-of-infectious-disease-epidemics-on-tuberculosis-diagnostic-management-and-prevention-services-experiences-and-lessons-from-the-2014-2015-ebola-virus-disease-outbreak-in-west-africa
#17
Rashid Ansumana, Samuel Keitell, Gregory M T Roberts, Francine Ntoumi, Eskild Petersen, Giuseppe Ippolito, Alimuddin Zumla
The World Health Organization (WHO) annual TB report states twenty-eight percent of the world's 9.6 million new tuberculosis (TB) cases are in the WHO Africa Region. The Mano River Union (MRU) countries of West Africa, Guinea, Sierra Leone and Liberia, have over the past two decades made incremental sustained investments into TB control programs. The devastating 2014-2015 Ebola Virus Disease (EVD) outbreak in West Africa impacted significantly on all sectors of the healthcare systems in the MRU countries, including the TB prevention and control programs...
November 3, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27816661/novel-approaches-to-tb-vaccine-development
#18
Stefan H E Kaufmann, January Weiner, C Fordham von Reyn
Tuberculosis (TB) remains the deadliest infectious disease. The widely used BCG vaccine offers only limited protection against TB. New vaccine candidates for TB include subunit vaccines, inactivated whole cell vaccines as well as live mycobacterial vaccines. In this review, we summarize current developments for TB vaccines.
November 2, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27815312/antibody-profiles-induced-by-t-cruzi-in-chagasic-patients-with-previous-or-current-exposure-to-mycobacteria
#19
Luz Peverengo, Estefanía Prochetto, Luz Rodeles, Ignacio Valenzuela, Iván Sergio Marcipar, Oscar Bottasso, Miguel Hernán Vicco
Since the immune response mounted by the host to a particular microorganism might be influenced by the acquired immunological experience due to previous contact with other microorganism, we performed a cross-sectional study to explore the pattern of T. cruzi-infection related antibodies in T. cruzi-seropositive individuals presenting concomitant tuberculosis, or the antecedent of BCG vaccination. Sampled individuals were grouped as follows: patients with Chagas disease, not vaccinated with BCG, who further developed pulmonary tuberculosis; individuals with Chagas disease BCG-vaccinated; and subjects with Chagas disease, presenting neither BCG scar nor tuberculosis disease...
November 3, 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27815271/immunogenic-properties-of-lactobacillus-plantarum-producing-surface-displayed-mycobacterium-tuberculosis-antigens
#20
Katarzyna Kuczkowska, Charlotte R Kleiveland, Rajna Minic, Lars F Moen, Lise Øverland, Rannei Tjåland, Harald Carlsen, Tor Lea, Geir Mathiesen, Vincent G H Eijsink
: Tuberculosis (TB) remains among the most deadly diseases in the world. The only available vaccine against tuberculosis is the BCG vaccine, which does not ensure full protection in adults. The development of an effective vaccine preventing disease transmission remains a global urgency and requires novel approaches. We are exploring the use of lactic acid bacteria (LAB) as a vector for antigen delivery to mucosal sites. Here, we demonstrate successful expression and surface display of a Mycobacterium tuberculosis fusion antigen (Ag85B&ESAT-6;, referred to as AgE6) in Lactobacillus plantarum The AgE6 fusion antigen was targeted to the bacterial surface using two different anchors, a lipoprotein anchor directing the protein to the cell membrane and a covalent cell wall anchor...
November 4, 2016: Applied and Environmental Microbiology
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