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Canonical pathways in peripheral blood in stroke patients

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https://www.readbyqxmd.com/read/29201025/regulation-of-neuroinflammation-what-role-for-the-tumor-necrosis-factor-like-weak-inducer-of-apoptosis-fn14-pathway
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Audrey Boulamery, Sophie Desplat-Jégo
Observed in many central nervous system diseases, neuroinflammation (NI) proceeds from peripheral immune cell infiltration into the parenchyma, from cytokine secretion and from oxidative stress. Astrocytes and microglia also get activated and proliferate. NI manifestations and consequences depend on its context and on the acute or chronic aspect of the disease. The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway has been involved in chronic human inflammatory pathologies such as neurodegenerative, autoimmune, or malignant diseases...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/20837969/genomic-biomarkers-and-cellular-pathways-of-ischemic-stroke-by-rna-gene-expression-profiling
#2
T L Barr, Y Conley, J Ding, A Dillman, S Warach, A Singleton, M Matarin
OBJECTIVE: The objective of this study was to provide insight into the molecular mechanisms of acute ischemic cerebrovascular syndrome (AICS) through gene expression profiling and pathway analysis. METHODS: Peripheral whole blood samples were collected from 39 MRI-diagnosed patients with AICS and 25 nonstroke control subjects ≥ 18 years of age. Total RNA was extracted from whole blood stabilized in Paxgene RNA tubes, amplified, and hybridized to Illumina HumanRef-8v2 bead chips...
September 14, 2010: Neurology
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