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JOURNAL ARTICLE
Clément Daigmorte, Daniela Usturoi, Clément Fournier, Frederic Wallyn, Christine Lorut, Valentin Héluain, Julien Mazières, Julien Legodec, Bruno Escarguel, Thomas Egenod, Laurent Cellerin, Nicolas Favrolt, Samy Lachkar, Adrian Crutu, Amandine Briault, Christophe Gut-Gobert, Valerian Bourinet, Juliette Camuset, Perrot Loïc, Pascal Schlossmacher, Michele Porzio, Antoine Luchez, Jean-Michel Vergnon, Marie-Christelle Pajiep Chapda, Pascalin Roy, Hervé Dutau, Nicolas Guibert
BACKGROUND AND OBJECTIVE: Little is known about malignant central airway obstruction (MCAO) complicating the metastatic spread of non-bronchogenic solid cancers (NBC) and their bronchoscopic management. This study aimed to describe the epidemiology of this population and determine prognostic factors before therapeutic bronchoscopy (TB). METHODS: In this multicenter study using the EpiGETIF registry, we analysed patients treated with TB for MCAO caused by NBC between January 2019 and December 2022...
April 18, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
#2
JOURNAL ARTICLE
Shunsuke Kasai, Etsuko Sato, Chikara Sakaguchi, Yasutsuna Sasaki
Tumor lysis syndrome (TLS) is a fatal complication associated with chemotherapy. We herein report a case of TLS in a 73-year-old woman with metastatic BRAFV600E mutated colon cancer after she received combined treatment with cetuximab and encorafenib. The serum uric acid, urea nitrogen, and creatinine levels were elevated on day four of the first cycle. The fibrin degradation product (FDP) and D-dimer levels were also high. Diuresis and rasburicase were initiated for TLS, and the laboratory data all normalized on day 8...
April 16, 2024: Internal Medicine
#3
Hyunbin D Huh, Hyun Woo Park
Cancer cells metastasize to distant organs by altering their characteristics within the tumor microenvironment (TME) to effectively overcome challenges during the multistep tumorigenesis. Plasticity endows cancer cell with the capacity to shift between different states to invade, disseminate, and seed metastasis. The epithelial-to-mesenchymal transition (EMT) is a cellular program that abrogates cell-cell adhesions by EMT transcription factors (TF) and acquires mesenchymal features during cancer progression...
April 17, 2024: BMB Reports
#4
JOURNAL ARTICLE
Luigi Asmundo, Valentina Ambrosini, Mark A Anderson, Stefano Fanti, William R Bradley, Davide Campana, Amirkasra Mojtahed, Ryan Chung, Shaunagh Mcdermott, Subba Digumarthy, Stephan Ursprung, Konstantin Nikolau, Florian J Fintelmann, Michael Blake, Carlos Fernandez-Del Castillo, Motaz Qadan, Ankur Pandey, Jeffrey W Clark, Onofrio A Catalano
Neuroendocrine neoplasms (NENs) are rare neoplasms originating from neuroendocrine cells, with increasing incidence due to enhanced detection methods. These tumors display considerable heterogeneity, necessitating diverse management strategies based on factors like organ of origin and tumor size. This article provides a comprehensive overview of therapeutic approaches for NENs, emphasizing the role of imaging in treatment decisions. It categorizes tumors based on their locations: gastric, duodenal, pancreatic, small bowel, colonic, rectal, appendiceal, gallbladder, prostate, lung, gynecological, and others...
April 15, 2024: Journal of Computer Assisted Tomography
#5
JOURNAL ARTICLE
Malte Gronewold, Isabel Grote, Stephan Bartels, Henriette Christgen, Leonie D Kandt, Maria Jose Brito, Gàbor Cserni, Maximilian E Daemmrich, Franz Fogt, Burkhard M Helmke, Natalie Ter Hoeve, Corinna Lang-Schwarz, Michael Vieth, Axel Wellmann, Elna Kuehnle, Ulf Kulik, Gesa Riedel, Tanja Reineke-Plaass, Ulrich Lehmann, Thijs Koorman, Patrick Wb Derksen, Hans Kreipe, Matthias Christgen
Invasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel...
March 2024: Journal of Pathology. Clinical Research
#6
Lijuan He, Haiyuan Li, Yunpeng Wang, Weidong Li, Lei Gao, Bo Xu, Jike Hu, Puyi He, Weigao Pu, Guodong Sun, Zhuanfang Wang, Qinying Han, Ben Liu, Hao Chen
Metastatic colon cancer remains an incurable disease, and it is difficult for existing treatments to achieve the desired clinical outcome, especially for colon cancer patients who have received first-line treatment. Although immune checkpoint inhibitors (ICIs) have demonstrated durable clinical efficacy in a variety of solid tumors, their response requires an inflammatory tumor microenvironment. However, microsatellite-stable ( MSS ) colon cancer, which accounts for the majority of colorectal cancers, is a cold tumor that does not respond well to ICIs...
2024: Frontiers in Immunology
#7
JOURNAL ARTICLE
Md Mazharul Islam
No abstract text is available yet for this article.
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#8
JOURNAL ARTICLE
Mahmut Emre Yildirim, Nuri Karadurmuş, İlker Nihat Ökten, Hacı Mehmet Türk, Zuhat Urakçı, Çağatay Arslan, Sinemis Çelik, Faysal Dane, Mehmet Ali Nahit Şendur, Cemil Bilir, Bülent Karabulut, İrfan Cicin, Erdem Çubukçu, Mustafa Karaca, Melike Ozcelik, Mehmet Artaç, Eda Tanrikulu, Ahmet Alacacioglu, Özgür Açıkgöz, Başak Öven, Çağlayan Geredeli, Timucin Çil, Hakan Harputluoğlu, Umut Kefeli, Oktay Bozkurt, Deniz Tural, Abdullah Sakin, Şuayip Yalçın, Mahmut Gumus
BACKGROUNDS AND OBJECTIVES: Colorectal cancer is one of the leading causes of mortality both globally and in our country. In Turkey, we conducted a multicenter investigation into the effectiveness of second-line treatments and real-life data for patients with RAS wild-type metastatic colorectal cancer (NCT04757311). MATERIALS AND METHODS: In this retrospective analysis, records from 28 centers were collected, and histopathological, molecular, and clinical characteristics were documented...
April 13, 2024: Journal of Oncology Pharmacy Practice
#9
JOURNAL ARTICLE
Abdullah Mahmood Ali, Azra Raza
Metastatic cancer is a leading cause of death in cancer patients worldwide. While circulating hybrid cells (CHCs) are implicated in metastatic spread, studies documenting their tissue origin remain sparse, with limited candidate approaches using one-two markers. Utilizing high-throughput single-cell and spatial transcriptomics, we identified tumor hybrid cells (THCs) co-expressing epithelial and macrophage markers and expressing a distinct transcriptome. Rarely, normal tissue showed these cells (NHCs), but their transcriptome was easily distinguishable from THCs...
April 8, 2024: Cancers
#10
JOURNAL ARTICLE
Vugar Yagublu, Bayram Bayramov, Christoph Reissfelder, Javahir Hajibabazade, Shalala Abdulrahimli, Michael Keese
Chemotherapy drugs efficiently eradicate rapidly dividing differentiated cells by inducing cell death, but poorly target slowly dividing cells, including cancer stem cells and dormant cancer cells, in the later course of treatment. Prolonged exposure to chemotherapy results in a decrease in the proportion of apoptotic cells in the tumour mass. To investigate and characterize the molecular basis of this phenomenon, microarray-based expression analysis was performed to compare tHcred2 -DEVD-EGFP-caspase 3-sensor transfected C-26 tumour cells that were harvested after engraftment into mice treated with or without 5-FU...
April 12, 2024: Clinical & Experimental Metastasis
#11
JOURNAL ARTICLE
Xiaoyun Li, Yining Xiang, Yunhuan Zhen, Yong Yu
Carrilizumab, a PD-1 inhibitor, has shown therapeutic effectiveness in patients with late-stage or metastatic solid tumors exhibiting DNA mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H). dMMR/MSI-H cancer patients are known to be responsive to PD-1 inhibitors. However, the use of carrilizumab for preoperative immunotherapy in early, unresectable MSI-H/dMMR primary colon cancer lesions is relatively underexplored. We present the case of a 46-year-old male who sought medical attention at our institution due to a history of hematochezia for two weeks, right-sided abdominal pain for one week, and loose stools...
April 11, 2024: Zeitschrift Für Gastroenterologie
#12
JOURNAL ARTICLE
Elysse C Filipe, Sipiththa Velayuthar, Ashleigh Philp, Max Nobis, Sharissa L Latham, Amelia L Parker, Kendelle J Murphy, Kaitlin Wyllie, Gretel S Major, Osvaldo Contreras, Ellie T Y Mok, Ronaldo F Enriquez, Suzanne McGowan, Kristen Feher, Lake-Ee Quek, Sarah E Hancock, Michelle Yam, Emmi Tran, Yordanos F I Setargew, Joanna N Skhinas, Jessica L Chitty, Monica Phimmachanh, Jeremy Z R Han, Antonia L Cadell, Michael Papanicolaou, Hadi Mahmodi, Beata Kiedik, Simon Junankar, Samuel E Ross, Natasha Lam, Rhiannon Coulson, Jessica Yang, Anaiis Zaratzian, Andrew M Da Silva, Michael Tayao, Ian L Chin, Aurélie Cazet, Maya Kansara, Davendra Segara, Andrew Parker, Andrew J Hoy, Richard P Harvey, Ozren Bogdanovic, Paul Timpson, David R Croucher, Elgene Lim, Alexander Swarbrick, Jeff Holst, Nigel Turner, Yu Suk Choi, Irina V Kabakova, Andrew Philp, Thomas R Cox
In recent decades, the role of tumor biomechanics on cancer cell behavior at the primary site has been increasingly appreciated. However, the effect of primary tumor biomechanics on the latter stages of the metastatic cascade, such as metastatic seeding of secondary sites and outgrowth remains underappreciated. This work sought to address this in the context of triple negative breast cancer (TNBC), a cancer type known to aggressively disseminate at all stages of disease progression. Using mechanically tuneable model systems, mimicking the range of stiffness's typically found within breast tumors, it is found that, contrary to expectations, cancer cells exposed to softer microenvironments are more able to colonize secondary tissues...
April 11, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#13
João Martins Gama, Rui Caetano Oliveira, Rúben Fonseca, Maria Augusta Cipriano, José Casanova
Extraskeletal myxoid chondrosarcoma is a rare soft tissue tumour with a high local and distant metastasis rate and limited response to chemotherapy. Meckel's diverticulum is the most frequent congenital anomaly, and it is associated with a considerable risk of malignant transformation. In this case report, we describe a 50-year-old female patient with a history of extraskeletal myxoid chondrosarcoma of the lower limb and metastasis to the forearm who went to the emergency department with abdominal pain. The investigations revealed a caecal volvulus...
2024: Revista Española de Patología
#14
JOURNAL ARTICLE
Zachary Alan Wilkinson, Maria Luisa C Policarpio-Nicolas
This report describes the cytologic features of a recently described MXD4::NUTM1-rearranged colonic sarcoma metastatic to the midclavicular soft tissue. Thirteen years ago, a 65-year-old woman presented with a cecal mass and subsequent liver mass. The cecal mass was diagnosed as malignant undifferentiated spindled and epithelioid neoplasm based on morphology and lack of tumor immunoreactivity with a panel of epithelial, smooth muscle, skeletal, melanoma, hematologic, and GIST markers. The liver mass showed morphologic and immunophenotypic similarity to the epithelioid component of the patient's cecal mass, albeit devoid of the spindled component...
April 9, 2024: Diagnostic Cytopathology
#15
JOURNAL ARTICLE
Davide Ciardiello, Erika Martinelli, Teresa Troiani, Gianluca Mauri, Daniele Rossini, Giulia Martini, Stefania Napolitano, Vincenzo Famiglietti, Sara Del Tufo, Gianluca Masi, Daniele Santini, Antonio Avallone, Filippo Pietrantonio, Sara Lonardi, Massimo Di Maio, Maria Giulia Zampino, Nicola Fazio, Alberto Bardelli, Salvatore Siena, Chiara Cremolini, Andrea Sartore-Bianchi, Fortunato Ciardiello
IMPORTANCE: The available evidence regarding anti-epidermal growth factor receptor (EGFR) inhibitor rechallenge in patients with refractory circulating tumor DNA (ctDNA) RAS/BRAF wild-type (wt) metastatic colorectal cancer (mCRC) is derived from small retrospective and prospective studies. OBJECTIVE: To evaluate the efficacy of anti-EGFR rechallenge in patients with refractory ctDNA RAS/BRAF wt mCRC. DESIGN, SETTING, AND PARTICIPANTS: This nonrandomized controlled trial used a pooled analysis of individual patient data from patients with RAS/BRAF wt ctDNA mCRC enrolled in 4 Italian trials (CAVE, VELO, CRICKET, and CHRONOS) and treated with anti-EGFR rechallenge between 2015 and 2022 (median [IQR] follow-up, 28...
April 1, 2024: JAMA Network Open
#16
JOURNAL ARTICLE
Hiroyuki Arai, Takashi Tsuda, Yu Sunakawa, Mototsugu Shimokawa, Kohei Akiyoshi, Shinya Tokunaga, Hirokazu Shoji, Kenji Kunieda, Masahito Kotaka, Toshihiko Matsumoto, Yusuke Nagata, Takuro Mizukami, Fumitaka Mizuki, Kathleen D Danenberg, Narikazu Boku, Takako Eguchi Nakajima
BACKGROUND: Long-term anti-EGFR antibody treatment increases the risk of severe dermatologic toxicities. This single-arm, phase II trial aimed to investigate the strategy of switching from cetuximab to bevacizumab in combination with FOLFIRI based on early tumor shrinkage (ETS) in patients with RAS wild-type metastatic colorectal cancer (mCRC). METHODS: Radiologic assessment was performed to evaluate ETS, defined as ≥20% reduction in the sum of the largest diameters of target lesions 8 weeks after the introduction of FOLFIRI plus cetuximab...
April 2024: Cancer Medicine
#17
JOURNAL ARTICLE
Ming-Cheng Chen, Hema Sri Devi, Hsueh-Fa Pien, Shina Fong-Mei Wen, Jenn-Line Sheu, Bruce Chi-Kang Tsai, Chih-Yang Huang, Yu-Jung Lin
Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality worldwide. The current standard of care includes systemic chemotherapy with cytotoxic agents, offering palliative relief for severe CRC cases and serving as the primary therapy for metastatic recurrence. However, the development of chemoresistance poses a substantial obstacle in the realm of chemotherapy. This study delved into the potential of a novel chromium (III)-based compound, hexaacetotetraaquadihydroxochromium (III) diiron (III) nitrate, for CRC treatment...
2024: American Journal of Cancer Research
#18
Y Zhan, B Burkel, E J Leaman, S M Ponik, B Behkam
Bacteria-based cancer therapy (BBCT) strains grow selectively in primary tumors and metastases, colonize solid tumors independent of genetics, and kill cells resistant to standard molecular therapy. Clinical trials of BBCT in solid tumors have not reported any survival advantage yet, partly due to the limited bacterial colonization. Collagen, abundant in primary and metastatic solid tumors, has a well-known role in hindering intratumoral penetration of therapeutics. Nevertheless, the effect of collagen content on the intratumoral penetration and antitumor efficacy of BBCT is rarely unexplored...
March 30, 2024: bioRxiv
#19
REVIEW
Mohammad Yasin Zamanian, Maryam Golmohammadi, Bekhzod Abdullaev, María Olalla García, Adeeb Abdulally Abdulhussien Alazbjee, Abhinav Kumar, Sameer S Mohaamed, Beneen M Hussien, Fattaneh Khalaj, Seyede Mahsa Hodaei, Niyousha Shirsalimi, Gervason Moriasi
Colorectal cancer (CRC) is a common and highly metastatic cancer affecting people worldwide. Drug resistance and unwanted side effects are some of the limitations of current treatments for CRC. Naringenin (NAR) is a naturally occurring compound found in abundance in various citrus fruits such as oranges, grapefruits, and tomatoes. It possesses a diverse range of pharmacological and biological properties that are beneficial for human health. Numerous studies have highlighted its antioxidant, anticancer, and anti-inflammatory activities, making it a subject of interest in scientific research...
April 2024: Cell Biochemistry and Function
#20
JOURNAL ARTICLE
Vasudeva Bhat, Matthew Piaseczny, David Goodale, Urvi Patel, Ashkan Sadri, Alison L Allan
Patients with triple-negative breast cancer (TNBC) have an increased propensity to develop lung metastasis. Our previous studies demonstrated that stem-like ALDHhi CD44+ breast cancer cells interact with lung-derived soluble factors, resulting in enhanced migration and lung metastasis particularly in TNBC models. We have also observed that the presence of a primary TNBC tumor can 'prime' the lung microenvironment in preparation for metastasis. In this study, we hypothesized that soluble lung-derived factors secreted in the presence of a primary TNBC tumor can influence stemness/plasticity of breast cancer cells...
April 6, 2024: Clinical & Experimental Metastasis
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