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https://www.readbyqxmd.com/read/29032738/long-term-survival-in-a-patient-with-low-level-inflammatory-markers-and-liver-metastasis-converted-resectable-by-tace
#1
Malkhaz Mizandari, Natela Paksashvili, Nino Kikodze, Tamta Azrumelashvili, Ia Pantsulaia, Koba Shanava, Nona Janikashvili, Tinatin Chikovani
Case report presents the successful treatment of unresectable liver metastasis in a patient with colon cancer. A 44-year-old male underwent right hemicolectomy followed by capecitabine for a moderately differentiated adenocarcinoma of the colon. 2 years later, a liver metastatic lesion was detected and had increased in size despite chemotherapy with capecitabine plus oxaliplatin (XELOX). Curative liver resection was conducted after conversion of unresectable tumor to resectable by transarterial chemoembolization followed by chemotherapy - irinotecan with fluorouracil and folinic acid (FOLFIRI)...
October 2017: Immunotherapy
https://www.readbyqxmd.com/read/29032693/from-utopia-to-reality-increased-survival-in-peritoneal-carcinomatosis-treated-with-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy
#2
Juan José Segura-Sampedro, Rafael Morales-Soriano
We have read with great interest the article by Illán et al.1 entitled "Long survival in a patient with metastatic colorectal carcinoma: reality or utopia?" This article describes the case of a 42 year old patient with mucinous-type colon adenocarcinoma who had tumor recurrence with peritoneal metastases 18 months after resection of the primary tumor and adjuvant chemotherapy. After multiple metastasectomies and several lines of chemotherapy, the patient died 27 months after the recurrence.
October 16, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29032203/construction-of-artificial-human-peritoneal-tissue-by-cell-accumulation-technique-and-its-application-for-visualizing-morphological-dynamics-of-cancer-peritoneal-metastasis
#3
Yoshiya Asano, Tadashi Odagiri, Hiroe Oikiri, Michiya Matsusaki, Mitsuru Akashi, Hiroshi Shimoda
Human peritoneum is composed of mesothelial monolayer and stromal tissue containing microvasculature. Dissemination and infiltration of cancer cells to the peritoneum result in cancer peritoneal metastasis which is an important prognostic factor of intraperitoneal or intrapelvic carcinoma. To elucidate an initial metastatic mechanism of cancer cells, in vitro human peritoneal models are demanded. In this study, we created a three-dimensional artificial human peritoneal tissue (AHPT) harboring the blood or lymphatic vascular network by cell-accumulation technique...
October 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29029886/heterogeneity-in-treatment-response-of-spine-metastases-to-spine-stereotactic-radiosurgery-within-radiosensitive-subtypes
#4
Vincent Bernard, Andrew J Bishop, Pamela K Allen, Behrang Amini, Xin A Wang, Jing Li, Claudio E Tatsui, Laurence D Rhines, Paul D Brown, Amol J Ghia
PURPOSE: To characterize outcomes of metastatic colorectal and non-small cell lung cancer (NSCLC) histologies, compared with other radiosensitive histologies, treated with spine stereotactic radiosurgery with regard to local control, overall survival, and predictors of response. METHODS AND MATERIALS: A total of 127 patients with 148 spine stereotactic radiosurgery-treated metastatic lesions at our institution between 2003 and 2013 were reviewed. We assessed clinical endpoints in relation to histologic type, including local control (LC) and overall survival (OS), using univariate and multivariate analyses...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29029495/metadherin-promotes-metastasis-by-supporting-putative-cancer-stem-cell-properties-and-epithelial-plasticity-in-pancreatic-cancer
#5
Kensuke Suzuki, Shigetsugu Takano, Hideyuki Yoshitomi, Hitoe Nishino, Shingo Kagawa, Hiroaki Shimizu, Katsunori Furukawa, Masaru Miyazaki, Masayuki Ohtsuka
Pancreatic ductal adenocarcinoma (PDAC) has a high metastatic potential. However, the mechanism of metastatic colonization in PDAC remains poorly understood. Metadherin (MTDH) has emerged in recent years as a crucial mediator of metastasis in several cancer types, although the biological role of MTDH in PDAC has not been investigated. Here, we demonstrated the functional roles of MTDH in PDAC progression, especially focusing on the metastatic cascade. In vitro studies showed that MTDH provides cancer stem cell (CSC) properties in metastatic PDAC cells and contributes to anoikis resistance with epithelial characteristics in PDAC cells...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029452/the-h3k27me3-demethylase-kdm6a-is-suppressed-in-breast-cancer-stem-like-cells-and-enables-the-resolution-of-bivalency-during-the-mesenchymal-epithelial-transition
#6
Joseph H Taube, Nathalie Sphyris, Kelsey S Johnson, Keighley N Reisenauer, Taylor A Nesbit, Robiya Joseph, Geraldine V Vijay, Tapasree R Sarkar, Neeraja A Bhangre, Joon Jin Song, Jeffrey T Chang, Min Gyu Lee, Rama Soundararajan, Sendurai A Mani
The deposition of the activating H3K4me3 and repressive H3K27me3 histone modifications within the same promoter, forming a so-called bivalent domain, maintains gene expression in a repressed but transcription-ready state. We recently reported a significantly increased incidence of bivalency following an epithelial-mesenchymal transition (EMT), a process associated with the initiation of the metastatic cascade. The reverse process, known as the mesenchymal-epithelial transition (MET), is necessary for efficient colonization...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029098/genital-granulomatosis-in-male-and-female-patients-with-crohn-s-disease-clinical-presentation-and-treatment-outcomes
#7
F Dederichs, I Iesalnieks, M Sladek, Ch Tzivinikos, R Hansen, C Muñoz, P Pavli, M N Cavicchi, V Abitbol, J-F Rahier, S R Vavricka, K Katsanos, E Domènech
Background: Genital granulomatosis (GG) is a metastatic form of Crohn's Disease (CD), characterized by granulomatous inflammation of the genital skin without contact to the gastrointestinal tract. Little is known about GG as most publications are case reports or small series, and only sporadic in male cases. Methods and Aims: Cases of GG were retrospectively collected through the Collaborative Network For Exceptionally Rare case reports project of the European Crohn´s and Colitis Organization...
September 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28991374/synaptopodin-2-suppresses-metastasis-of-triple-negative-breast-cancer-via-inhibition-of-yap-taz-activity
#8
Junling Liu, Liping Ye, Qingyuan Li, Xianqiu Wu, Bin Wang, Ying Ouyang, Zhongyu Yuan, Jun Li, Chuyong Lin
Triple negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer with a high incidence of distant metastasis; however, the underlying mechanism for this frequent recurrence remains unclear. Herein, we find that Synaptopodin 2, a putative tumor suppressor in aggressive cancer, is frequently downregulated in TNBC by methylation of the promoter of SYNPO2. Low expression levels of SYNPO2 correlated significantly with 5-year metastatic relapse, and predicted poorer prognosis in breast cancer patients...
October 9, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28990490/targeted-photodynamic-therapy-as-potential-treatment-modality-for-the-eradication-of-colon-cancer-and-colon-cancer-stem-cells
#9
Natasha Hodgkinson, Cherie A Kruger, Heidi Abrahamse
Colorectal cancer is commonly treated by tumour resection, as chemotherapy and radiation have proven to be less effective, especially if the tumour has metastasized. Resistance to therapies occurs in almost all patients with colorectal cancer, especially in those with metastatic tumours. Cancer stem cells have the ability to self-renew, and their slow rate of cycling enhances resistance to treatment and increases the likelihood of tumour recurrence. Most metastatic tumours are unable to be surgically removed, thus creating a need for treatment modalities that target cancers directly and destroy cancer stem cells...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28989814/engineering-the-pre-metastatic-niche
#10
Brian A Aguado, Grace G Bushnell, Shreyas S Rao, Jacqueline S Jeruss, Lonnie D Shea
The pre-metastatic niche - the accumulation of aberrant immune cells and extracellular matrix proteins in target organs - primes the initially healthy organ microenvironment and renders it amenable for subsequent metastatic cell colonization. By attracting metastatic cancer cells, mimics of the pre-metastatic niche offer both diagnostic and therapeutic potential. However, deconstructing the complexity of the niche by identifying the interactions between cell populations and the mediatory roles of the immune system, soluble factors, extracellular matrix proteins, and stromal cells has proved challenging...
2017: Nature biomedical engineering
https://www.readbyqxmd.com/read/28985870/polymeric-micelles-loaded-with-1-2-diaminocyclohexane-platinum-ii-against-colorectal-cancer
#11
Takako Nirei, Soichiro Ishihara, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Keisuke Hata, Hioaki Nozawa, Toshiaki Watanabe
BACKGROUND: We investigated the potential of nanomedicine in loading the oxaliplatin parent complex (1,2-diaminocyclohexane)platinum(II)-loaded polymeric micelles (DACHPt/m) against multiple liver metastases from colon cancer in a mouse model. MATERIALS AND METHODS: The efficacy of DACHPt/m or oxaliplatin (on days 14 and 21 after inoculation of tumor cells) was evaluated in a mouse model of liver metastasis for murine colon adenocarcinoma C26 cells. In vivo antitumor effects were evaluated by recording the number of liver metastases and weights of metastatic livers after treatment (day 28)...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28983781/the-distribution-of-lymph-node-metastases-and-their-size-in-colon-cancer
#12
Yusuke Yamaoka, Yusuke Kinugasa, Akio Shiomi, Tomohiro Yamaguchi, Hiroyasu Kagawa, Yushi Yamakawa, Akinobu Furutani, Shoichi Manabe
PURPOSE: The purpose of this study is to clarify the optimal extent of lymph node dissection for colon cancer by evaluating the distributions of lymph node metastases and lymph node size according to tumor location and T stage. METHODS: This study enrolled 662 patients who underwent curative resection for primary colon cancer between 2013 and 2015. Lymph node regions were classified into pericolic, intermediate, and main nodes. The short-axis diameter of each dissected lymph node was measured...
October 5, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28983112/the-lncrna-borg-drives-breast-cancer-metastasis-and-disease-recurrence
#13
Alex J Gooding, Bing Zhang, Fereshteh Kenari Jahanbani, Hannah L Gilmore, Jenny C Chang, Saba Valadkhan, William P Schiemann
Long noncoding RNAs (lncRNAs) have emerged as potent regulators of breast cancer development and progression, including the metastatic spread of disease. Through in silico and biological analyses, we identified a novel lncRNA, BMP/OP-Responsive Gene (BORG), whose expression directly correlates with aggressive breast cancer phenotypes, as well as with metastatic competence and disease recurrence in multiple clinical cohorts. Mechanistically, BORG elicits the metastatic outgrowth of latent breast cancer cells by promoting the localization and transcriptional repressive activity of TRIM28, which binds BORG and induces substantial alterations in carcinoma proliferation and survival...
October 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28982866/down-regulation-of-inositol-polyphosphate-4-phosphatase-type-ii-expression-in-colorectal-carcinoma
#14
Ji-Youn Sung, Kiyong Na, Hyun-Soo Kim
BACKGROUND/AIM: Aberrant expression of survival signaling pathways causes deregulation of cellular proliferation and resistance to apoptosis, and plays a crucial role in the development, progression and metastasis of cancer. Inositol polyphosphate 4-phosphatase type II (INPP4B) negatively regulates phosphatidylinositol 3-kinase signaling and has a tumor-suppressive role in several human malignancies. MATERIALS AND METHODS: We analyzed the expression levels of INPP4B mRNA and protein in colorectal carcinoma (CRC) cell lines and tissue samples using western blot, quantitative real-time reverse-transcriptase polymerase chain reaction, and immunohistochemical staining...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982515/robotic-total-pelvic-exenteration-with-intracorporeal-sigmoid-conduit-and-colostomy-step-by-step-technique
#15
Matthew J Maurice, Daniel Ramirez, Emre Gorgun, Georges-Pascal Haber
OBJECTIVE: To describe our technique for robotic total pelvic exenteration with intracorporeal sigmoid conduit and colostomy using the da Vinci Si robot. METHODS: Three 8-mm robotic ports and two 12-mm laparoscopic ports are placed in a "W" configuration, approximately 2-3 cm more cephalad than for radical prostatectomy (Fig. 1). The robot is docked between the legs with the patient in steep Trendelenburg. The ureters are dissected out from the iliac vessels to the rectovesical pouch, where they are clipped and transected...
July 2017: Urology
https://www.readbyqxmd.com/read/28981199/microrna-661-modulates-redox-and-metabolic-homeostasis-in-colon-cancer
#16
Marta Gómez de Cedrón, Rebeca Acín Pérez, Ruth Sánchez-Martínez, Susana Molina, Jesús Herranz, Jaime Feliu, Guillermo Reglero, Jose Antonio Enríquez, Ana Ramírez de Molina
Cancer cell survival and metastasis are dependent on metabolic reprogramming that is capable of increasing resistance to oxidative and energetic stress. Targeting these two processes can be crucial for cancer progression. Herein, we describe the role of microRNA-661 (miR661) as epigenetic regulator of colon cancer (CC) cell metabolism. miR661 induces a global increase in reactive oxygen species (ROS), specifically in mitochondrial superoxide anions (SO(-) ), which appears to be mediated by decreased carbohydrate metabolism and pentose phosphate pathway, and by a higher dependency on mitochondrial respiration...
October 5, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28978118/regorafenib-in-combination-with-silybin-as-a-novel-potential-strategy-for-the-treatment-of-metastatic-colorectal-cancer
#17
Valentina Belli, Vincenzo Sforza, Claudia Cardone, Erika Martinelli, Giusi Barra, Nunzia Matrone, Stefania Napolitano, Floriana Morgillo, Concetta Tuccillo, Alessandro Federico, Marcello Dallio, Carmelina Loguercio, Antonietta Gerarda Gravina, Raffaele De Palma, Fortunato Ciardiello, Teresa Troiani
PURPOSE: Regorafenib, an oral multikinase inhibitor, has demonstrated survival benefit in metastatic colorectal cancer (mCRC) patients that have progressed after all standard therapies. However, novel strategies to improve tolerability and enhance anti-cancer efficacy are needed. EXPERIMENTAL DESIGN: We have evaluated in vitro the effects of regorafenib in combination with silybin, a biologically active component extracted from the seeds of Silybum marianum, in a panel of human colon cancer cells...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976119/krukenberg-carcinoma-metastasized-from-stomach-resembling-mucinous-cystadenocarcinoma-of-the-ovary
#18
Melike Doğanay, Hasan Onur Topçu, Mahmut Kuntay Kokanalı, Ali I Rfan Güzel, Aslı Oskovi, Serap Akbay, Sabri Cavkaytar
The ovaries are common site of metastasis in a variety of primary neoplasms. Multiple tumors such as breast, lung, and pancreas have been reported to metastasize to the ovary, however; the colon and stomach are the most common primary cancer sites that of ovarian metastasis. An ovarian mass mostly originates from its self-tissue, but sometimes it can be a metastasis of a gastrointestinal system tumor. Such cases are often misdiagnosed as primary ovarian cancers. A 42-year-old woman was admitted to our hospital with pelvic pain...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28974231/clca1-suppresses-colorectal-cancer-aggressiveness-via-inhibition-of-the-wnt-beta-catenin-signaling-pathway
#19
Xiaofen Li, Wangxiong Hu, Jiaojiao Zhou, Yanqin Huang, Jiaping Peng, Ying Yuan, Jiekai Yu, Shu Zheng
BACKGROUND: Chloride channel accessory 1 (CLCA1) belongs to the calcium-sensitive chloride conductance protein family, which is mainly expressed in the colon, small intestine and appendix. This study was conducted to investigate the functions and mechanisms of CLCA1 in colorectal cancer (CRC). METHODS: The CLCA1 protein expression level in CRC patients was evaluated by enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC), and western blotting analysis...
October 3, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28971436/long-term-survival-of-women-with-breast-cancer-overview-supportive-care-needs-assessment-instruments
#20
Parthenopi Ktistaki, Nephely Alevra, Maria Voulgari
INTRODUCTION: Worldwide, breast cancer is the fifth leading cause of cancer death (after lung, stomach, liver and colon cancer), while among women it is first on the list. The incidence of breast cancer has made a dramatic increase since 1970 which is partly interpreted by the modern western life standards. The expected risk of breast cancer throughout a lifespan of an average is 1 in 11 women. The five-year survival rates for breast cancer are at 80% if it has not spread, and only at 40% for the metastatic type of cancer...
2017: Advances in Experimental Medicine and Biology
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