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https://www.readbyqxmd.com/read/29911510/mixed-adenoneuroendocrine-carcinoma-of-the-colon-and-rectum
#1
S Qiu, G Pellino, O J Warren, S Mills, R Goldin, C Kontovounisios, P P Tekkis
Mixed adenoneuroendocrine carcinoma (MANEC) are rare cancers of the gastrointestinal (GI) and pancreatobiliary tract. They are characterized by the presence of a combination of epithelial and neuroendocrine elements, where each component represents at least 30% of the tumour. Review of literature and consolidation of clinicopathological data. Sixty-one cases of colorectal MANEC have been reported in literature and one seen in this centre. The median age of the patients affected was 61.9 ± 12.4 years (20-94 years)...
June 17, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29908095/cytotoxic-anti-proliferative-and-apoptosis-inducing-activity-of-l-amino-acid-oxidase-laao-from-malaysian-calloselasma-rhodostoma-on-human-colon-cancer-cells
#2
Syafiq Asnawi Zainal Abidin, Pathmanathan Rajadurai, Md Ezharul Hoque Chowdhury, Muhammad Rusdi Ahmad Rusmili, Iekhsan Othman, Rakesh Naidu
The aim of this study was to investigate the cytotoxic, anti-proliferative activity, and the induction of apoptosis by L-amino acid oxidase isolated from C. rhodostoma crude venom (CR-LAAO) on human colon cancer cells. CR-LAAO was purified using three chromatographic steps: molecular exclusion using G-50 gel filtration resin, ion-exchange by MonoQ column and desalted on a G25 column. The purity and identity of the isolated CR-LAAO was confirmed by SDS-PAGE and LC-MS/MS. CR-LAAO demonstrated time- and dose-dependent cytotoxic activity on SW480 (primary human colon cancer cells) and SW620 (metastatic human colon cancer cells) with an EC50 values of 6 μg/ml and 7 μg/ml at 48 hr, respectively...
June 16, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29899427/treating-the-intestine-with-oral-apoa-i-mimetic-tg6f-reduces-tumor-burden-in-mouse-models-of-metastatic-lung-cancer
#3
Arnab Chattopadhyay, Xinying Yang, Pallavi Mukherjee, Dawoud Sulaiman, Hannah R Fogelman, Victor Grijalva, Steven Dubinett, Tonya C Wasler, Manash K Paul, Ramin Salehi-Rad, Julia J Mack, M Luisa Iruela-Arispe, Mohamad Navab, Alan M Fogelman, Srinivasa T Reddy
Having demonstrated that apolipoprotein A-I (apoA-I) mimetic peptides ameliorate cancer in mouse models, we sought to determine the mechanism for the anti-tumorigenic function of these peptides. CT-26 cells (colon cancer cells that implant and grow into tumors in the lungs) were injected into wild-type BALB/c mice. The day after injection, mice were either continued on chow or switched to chow containing 0.06% of a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F). After four weeks, the number of lung tumors was significantly lower in Tg6F-fed mice...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29898752/generation-of-her2-specific-antibody-immunity-during-trastuzumab-adjuvant-therapy-associates-with-reduced-relapse-in-resected-her2-breast-cancer
#4
Nadine Norton, Nicholas Fox, Christie-Ann McCarl, Kathleen S Tenner, Karla Ballman, Courtney L Erskine, Brian M Necela, Donald Northfelt, Winston W Tan, Carmen Calfa, Mark Pegram, Gerardo Colon-Otero, Edith A Perez, Raphael Clynes, Keith L Knutson
BACKGROUND: Resected HER2 breast cancer patients treated with adjuvant trastuzumab and chemotherapy have superior survival compared to patients treated with chemotherapy alone. We previously showed that trastuzumab and chemotherapy induce HER2-specific antibodies which correlate with improved survival in HER2 metastatic breast cancer patients. It remains unclear whether the generation of immunity required trastuzumab and whether endogenous antibody immunity is associated with improved disease-free survival in the adjuvant setting...
June 14, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29897402/primary-tumor-sidedness-and-benefit-from-folfoxiri-plus-bevacizumab-as-initial-therapy-for-metastatic-colorectal-cancer
#5
C Cremolini, C Antoniotti, S Lonardi, F Bergamo, E Cortesi, G Tomasello, R Moretto, M Ronzoni, P Racca, F Loupakis, A Zaniboni, G Tonini, A Buonadonna, F Marmorino, G Allegrini, C Granetto, G Masi, V Zagonel, E Sensi, G Fontanini, L Boni, A Falcone
Background: Right-sided metastatic colorectal cancer (mCRC) patients have poor prognosis and achieve limited benefit from first-line doublets plus a targeted agent. In this unplanned analysis of the TRIBE study, we investigated the prognostic and predictive impact of primary tumor sidedness in mCRC patients and the differential impact of the intensification of the chemotherapy in subgroups defined according to both primary tumor sidedness and RAS and BRAF mutational status. Patients and methods: Patients were randomized to receive upfront 5-fluoruracil, leucovorin, and irinotecan (FOLFIRI) plus bevacizumab or 5-fluoruracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) plus bevacizumab...
April 20, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29895100/anastomotic-leaks-in-stage-iv-colorectal-cancer
#6
Suat Chin Ng, Douglas Stupart, David Bartolo, David Watters
BACKGROUND: The purpose of this study was to determine the anastomotic leak rate for colorectal cancer resections in patients with metastases (compared to those without), and to determine the impact of anastomotic leaks on survival. METHODS: This is a retrospective analysis of all patients who underwent resection and primary anastomosis for colorectal adenocarcinoma at a single institution between January 2002 and December 2014. RESULTS: A total of 843 patients underwent a resection and primary anastomosis for colorectal adenocarcinoma (661 colon and 182 rectal)...
June 12, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29892069/stat3-labels-a-subpopulation-of-reactive-astrocytes-required-for-brain-metastasis
#7
Neibla Priego, Lucía Zhu, Cátia Monteiro, Manon Mulders, David Wasilewski, Wendy Bindeman, Laura Doglio, Liliana Martínez, Elena Martínez-Saez, Santiago Ramón Y Cajal, Diego Megías, Elena Hernández-Encinas, Carmen Blanco-Aparicio, Lola Martínez, Eduardo Zarzuela, Javier Muñoz, Coral Fustero-Torres, Elena Pineiro, Aurelio Hernández-Laín, Luca Bertero, Valeria Poli, Melchor Sánchez-Martínez, Javier A Menendez, Riccardo Soffietti, Joaquim Bosch-Barrera, Manuel Valiente
The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating cells, but successful metastases bypass this control through mechanisms that are poorly understood. Reactive astrocytes are key components of this microenvironment that confine brain metastasis without infiltrating the lesion. Here, we describe that brain metastatic cells induce and maintain the co-option of a pro-metastatic program driven by signal transducer and activator of transcription 3 (STAT3) in a subpopulation of reactive astrocytes surrounding metastatic lesions...
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29888107/downregulation-of-histone-demethylase-jmjd1c-inhibits-colorectal-cancer-metastasis-through-targeting-atf2
#8
Cheng Chen, Maimaiti Aihemaiti, Xin Zhang, Hui Qu, Qi-Long Sun, Qing-Si He, Wen-Bin Yu
Colorectal cancer (CRC) is one of the most common malignant gastrointestinal cancers. Metastasis is a major leading of death in patients with CRC and many patients have metastatic disease at diagnosis. However, the underlying molecular mechanisms are still elusive. Here, we showed that JMJD1C was overexpressed in colon cancer tissues compared to normal samples and was positively associated with metastasis and poor prognosis. Silencing JMJD1C strongly inhibits CRC migration and invasion both in vitro and in vivo...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29886834/verbascoside-attenuates-rac-1-and-hif-1%C3%AE-signaling-cascade-in-colorectal-cancer-cells
#9
Mohammad Nabiuni, Danial Seyfi, Seyed Bahram Behzad, Kazem Parivar, Mohammad Tahmaseb, Elaheh Amini
OBJECTIVE: Metastasis phenotype is considered as a main challenge in colon cancer therapeutic methods. Furthermore, the side effects of conventional colorectal cancer treatment methods, has attracted a lot of attention into natural ingredients. The aim of the study was to assess the molecular mechanism of verbascoside as natural bio-compound in human HT29 colon cancer cells. METHODS: HT29 cells were cultured in RPMI-1640 medium containing 10% FBS and 1% penicillin/streptomycin at 37˚C and 5% CO2...
June 10, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29879760/preclinical-efficacy-of-v4q5-ddavp-a-second-generation-vasopressin-analog-on-metastatic-spread-and-tumor-associated-angiogenesis-in-colorectal-cancer
#10
Juan Garona, Natasha T Sobol, Marina Pifano, Valeria I Segatori, Daniel E Gomez, Giselle V Ripoll, Daniel F Alonso
Purpose: Control of metastatic spread of colorectal cancer (CRC) remains as a major therapeutic challenge. [V4Q5]dDAVP is a vasopressin peptide analog with previously reported anticancer activity against carcinoma tumors. By acting as a selective agonist of AVPR2 present in endothelial and tumor cells, [V4Q5]dDAVP is able to impair tumor aggressiveness and distant spread. Our aim was to evaluate the potential therapeutic benefits of [V4Q5]dDAVP on highly aggressive CRC disease using experimental models with translational relevance...
June 1, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29879758/combination-treatment-of-stereotactic-body-radiation-therapy-and-immature-dendritic-cell-vaccination-for-augmentation-of-local-and-systemic-effects
#11
Chul Won Choi, Min Ho Jeong, You-Soo Park, Cheol-Hun Son, Hong-Rae Lee, Eun-Kyoung Koh
Purpose: The purpose of this study was to investigate the efficacy of stereotactic body radiation therapy (SBRT) as a tumor-associated antigen (TAA) presentation method for dendritic cell (DC) sensitization and evaluate its effect in combination with immunotherapy using an intratumoral injection of immature DCs (iDCs). Methods and Materials: CT-26 colon carcinoma cell was used as a cancer cell line. Annexin V staining and phagocytosis assays were performed to determine the appropriate radiation dose and incubation time to generate TAAs...
June 6, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29877977/multidisciplinary-diagnostic-and-surgical-management-of-adenocarcinoma-gingival-metastases
#12
Dario Di Stasio, Marco Montella, Immacolata Cozzolino, Marco Cicciù, Gabriele Cervino, Renato Silvio Paparella, Rosario Serpico, Luigi Laino
Colon cancer is the third leading cause of cancer-related mortality worldwide and colon cancer metastases in rare sites, such as the oral cavity, lead to a worse prognosis. Oral metastasis is a rare clinical condition and it represents only the 1% among all oral cavity neoplasms. A multidisciplinary approach is recommended to carry out a correct diagnostic procedure that allows distinguishing between metastatic and primitive lesions of the oral cavity. Quick diagnosis and management are fundamental to take an appropriate action as early as possible, as usually the prognosis in patients with oral metastases of colon carcinoma is poor...
June 5, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29876002/evaluation-of-appropriate-follow-up-after-curative-surgery-for-patients-with-colorectal-cancer-using-time-to-recurrence-and-survival-after-recurrence-a-retrospective-multicenter-study
#13
Tomoki Yamano, Shinichi Yamauchi, Kiyoshi Tsukamoto, Masafumi Noda, Masayoshi Kobayashi, Michiko Hamanaka, Akihito Babaya, Kei Kimura, Chihyon Son, Ayako Imada, Shino Tanaka, Masataka Ikeda, Naohiro Tomita, Kenichi Sugihara
Introduction: The follow-up schedule for colorectal cancer patients after curative surgery is inconsistent among the guidelines. Evaluation of time to recurrence (TTR) and survival after recurrence (SAR) may provide evidence for appropriate follow-up. Methods: We assessed 3039 colon cancer (CC) and 1953 rectal cancer (RC) patients who underwent curative surgery between 2007 and 2008. We evaluated the pre- and post-recurrent clinicopathological factors associated with TTR and SAR in each stage of CC and RC...
May 22, 2018: Oncotarget
https://www.readbyqxmd.com/read/29873679/primary-tumor-sidedness-and-benefit-from-folfoxiri-plus-bevacizumab-as-initial-therapy-for-metastatic-colorectal-cancer-retrospective-analysis-of-the-tribe-trial-by-gono
#14
C Cremolini, C Antoniotti, S Lonardi, F Bergamo, E Cortesi, G Tomasello, R Moretto, M Ronzoni, P Racca, F Loupakis, A Zaniboni, G Tonini, A Buonadonna, F Marmorino, G Allegrini, C Granetto, G Masi, V Zagonel, E Sensi, G Fontanini, L Boni, A Falcone
Background: Right-sided metastatic colorectal cancer (mCRC) patients have poor prognosis and achieve limited benefit from first-line doublets plus a targeted agent. In this unplanned analysis of the TRIBE study, we investigated the prognostic and predictive impact of primary tumor sidedness in mCRC patients and the differential impact of the intensification of the chemotherapy in subgroups defined according to both primary tumor sidedness and RAS and BRAF mutational status. Patients and methods: Patients were randomized to receive upfront 5-fluoruracil, leucovorin, and irinotecan (FOLFIRI) plus bevacizumab or 5-fluoruracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) plus bevacizumab...
April 20, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29872559/rankl-blockade-improves-efficacy-of-pd1-pd-l1-blockade-or-dual-pd1-pd-l1-and-ctla4-blockade-in-mouse-models-of-cancer
#15
Elizabeth Ahern, Heidi Harjunpää, Jake S O'Donnell, Stacey Allen, William C Dougall, Michele W L Teng, Mark J Smyth
Receptor activator of NF-κB ligand (RANKL) and its receptor RANK, are members of the tumor necrosis factor and receptor superfamilies, respectively. Antibodies targeting RANKL have recently been evaluated in combination with anti-CTLA4 in case reports of human melanoma and mouse models of cancer. However, the efficacy of anti-RANKL in combination with antibodies targeting other immune checkpoint receptors such as PD1 has not been reported. In this study, we demonstrated that blockade of RANKL improves anti-metastatic activity of antibodies targeting PD1/PD-L1 and improves subcutaneous growth suppression in mouse models of melanoma, prostate and colon cancer...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29871931/interleukin-like-emt-inducer-ilei-promotes-melanoma-invasiveness-and-is-transcriptionally-up-regulated-by-upstream-stimulatory-factor-1-usf-1
#16
Ken Noguchi, Toros A Dincman, Annamarie C Dalton, Breege V Howley, Buckley J McCall, Bidyut K Mohanty, Philip H Howe
Interleukin-like EMT Inducer (ILEI,FAM3C) is a secreted factor that contributes to the epithelial-to-mesenchymal transition (EMT), a cell biological process that confers metastatic properties to a tumor cell. However, very little is known about how ILEI is regulated. Here we demonstrate that ILEI is anin vivo regulator of melanoma invasiveness and is transcriptionally up-regulated by the upstream stimulatory factor-1 (USF-1), an E- box-binding, basic-helix-loop-helix family transcription factor. shRNA-mediated knockdown of ILEI in melanoma cell lines attenuated lung colonization but not primary tumor formation...
June 5, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29867227/immune-recognition-of-somatic-mutations-leading-to-complete-durable-regression-in-metastatic-breast-cancer
#17
Nikolaos Zacharakis, Harshini Chinnasamy, Mary Black, Hui Xu, Yong-Chen Lu, Zhili Zheng, Anna Pasetto, Michelle Langhan, Thomas Shelton, Todd Prickett, Jared Gartner, Li Jia, Katarzyna Trebska-McGowan, Robert P Somerville, Paul F Robbins, Steven A Rosenberg, Stephanie L Goff, Steven A Feldman
Immunotherapy using either checkpoint blockade or the adoptive transfer of antitumor lymphocytes has shown effectiveness in treating cancers with high levels of somatic mutations-such as melanoma, smoking-induced lung cancers and bladder cancer-with little effect in other common epithelial cancers that have lower mutation rates, such as those arising in the gastrointestinal tract, breast and ovary1-7 . Adoptive transfer of autologous lymphocytes that specifically target proteins encoded by somatically mutated genes has mediated substantial objective clinical regressions in patients with metastatic bile duct, colon and cervical cancers8-11 ...
June 2018: Nature Medicine
https://www.readbyqxmd.com/read/29867200/decreased-expression-of-arhgap15-promotes-the-development-of-colorectal-cancer-through-pten-akt-foxo1-axis
#18
Shengli Pan, Yingying Deng, Jun Fu, Yuhao Zhang, Zhijin Zhang, Xiaokun Ru, Xianju Qin
Copious evidence demonstrates the crucial role of Rho GTPase-activating proteins in human malignancies. The downregulation of Rho GTPase-activating protein 15 (ARHGAP15), a Rac1-specific GAP, has been observed in glioma and pancreatic ductal adenocarcinoma. The present study explored the expression in colorectal cancer (CRC) by quantitative real-time PCR and immunohistochemistry analysis. The possible function of ARHGAP15 in CRC was investegated in vitro and in vivo. We found that ARHGAP15 expression was obviously lower in CRC specimens than in normal colonic mucosa...
June 4, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29866746/development-of-mgd007-a-gpa33-x-cd3-bispecific-dart%C3%A2-protein-for-t-cell-immunotherapy-of-metastatic-colorectal-cancer
#19
Paul A Moore, Kalpana Shah, Yinhua Yang, Ralph Alderson, Penny Roberts, Vatana Long, Daorong Liu, Jonathan C Li, Steve Burke, Valentina Ciccarone, Hua Li, Claudia B Fieger, Jeff Hooley, Ann Easton, Monica Licea, Sergey Gorlatov, Kathleen L King, Peter Young, Arash Adami, Deryk Loo, Gurunadh R Chichili, Liqin Liu, Douglas H Smith, Jennifer G Brown, Francine Z Chen, Scott Koenig, Jennie Mather, Ezio Bonvini, Syd Johnson
We have developed MGD007 (anti-glycoprotein A33 x anti-CD3), a DART® protein designed to redirect T-cells to target gpA33 expressing colon cancer. The gpA33 target was selected based on an antibody-based screen to identify cancer antigens universally expressed in both primary and metastatic CRC specimens, including putative cancer stem cell populations. MGD007 displays the anticipated bispecific binding properties and mediates potent lysis of gpA33-positive cancer cell lines, including models of colorectal cancer stem cells, through recruitment of T-cells...
June 4, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29865211/emerging-and-established-models-of-bone-metastasis
#20
REVIEW
Alexander H Jinnah, Benjamin C Zacks, Chukwuweike U Gwam, Bethany A Kerr
Metastasis is the leading cause of cancer-related death and drives patient morbidity as well as healthcare costs. Bone is the primary site of metastasis for several cancers-breast and prostate cancers in particular. Efforts to treat bone metastases have been stymied by a lack of models to study the progression, cellular players, and signaling pathways driving bone metastasis. In this review, we examine newly described and classic models of bone metastasis. Through the use of current in vivo, microfluidic, and in silico computational bone metastasis models we may eventually understand how cells escape the primary tumor and how these circulating tumor cells then home to and colonize the bone marrow...
June 1, 2018: Cancers
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