Daniel Marrero-Rodriguez, Victor A Cortes-Morales, Amayrani Cano-Zaragoza, Florencia Martinez-Mendoza, Jacobo Kerbel-Suton, Sandra Vela-Patiño, Alejandra Chavez-Santoscoy, Silvia Hinojosa-Alvarez, Jesus Hernandez-Perez, Erick Gomez-Apo, Guadalupe R Fajardo-Orduña, Keiko Taniguchi-Ponciano, Juan Jose Montesinos, Moises Mercado
BACKGROUND: The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells among others. MSC have been isolated from different tumors and they favor tumor cell growth, however, their role in pituitary tumors (PT) remains unknown. Herein we report the presence of MSCs in 2 ACTH-secreting PT causing Cushing disease (MCU), 2 nonfunctioning adenomas of gonadotrope differentiation (MNF) and 2 non tumoral pituitary glands (MS). METHODS: We have analyzed their transcriptomic profiles by RNAseq and compared MSC in terms of their immunosuppressive effects against lymphoid T cell and macrophage populations by means of co-cultures and flow cytometry...
April 9, 2024: Journal of Clinical Endocrinology and Metabolism