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b type natriuretic peptide

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https://www.readbyqxmd.com/read/29450407/changes-in-the-cardiac-ghsr1a-ghrelin-system-correlate-with-myocardial-dysfunction-in-diabetic-cardiomyopathy-in-mice
#1
Rebecca Sullivan, Rebecca McGirr, Shirley Hu, Alice Tan, Derek Wu, Carlie Charron, Tyler Lalonde, Edith Arany, Subrata Chakrabarti, Leonard Luyt, Savita Dhanvantari
Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are present in cardiac tissue. Activation of GHSR1a by ghrelin promotes cardiomyocyte contractility and survival, and changes in myocardial GHSR1a and circulating ghrelin track with end-stage heart failure, leading to the hypothesis that GHSR1a is a biomarker for heart failure. We hypothesized that GHSR1a could also be a biomarker for diabetic cardiomyopathy (DCM). We used two models of streptozotocin (STZ)-induced DCM: group 1, adult mice treated with 35 mg/kg STZ for 3 days; and group 2, neonatal mice treated with 70 mg/kg STZ at days 2 and 5 after birth...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29444778/efficacy-and-safety-of-the-shexiang-baoxin-pill-for-the-treatment-of-coronary-artery-disease-not-amenable-to-revascularisation-study-protocol-for-a-randomised-placebo-controlled-double-blinded-trial
#2
Pan-Pan Tian, Jun Li, Jian Gao, Ying Li
INTRODUCTION: Coronary artery disease (CAD) not amenable to revascularisation indicates that the coronary arteries have severe diffuse lesions or calcifications, or that CAD is complicated with severe multiple-organ disease. Currently, Western medicines available for the treatment of CAD not amenable to revascularisation are limited. Shexiang Baoxin Pill (SBP), a type of Chinese patent medicine, has been widely used to treat CAD in China for many years. Previous studies have shown that long-term administration of SBP (1-2 pills three times daily, for at least 6 months) for treatment of CAD is effective and safe, with a significant, long-term effect...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438191/the-association-between-depressive-symptoms-and-n-terminal-pro-b-type-natriuretic-peptide-with-functional-status-in-patients-with-heart-failure
#3
Zyad T Saleh, Jia-Rong Wu, Ibrahim Salami, Khalil Yousef, Terry A Lennie
BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and depressive symptoms are each associated with functional status in patients with heart failure (HF), but their association together with functional status has not been examined. OBJECTIVE: The aim of this study was to determine whether functional status scores differ as a function of depressive symptoms and NT-proBNP levels considered together. METHODS: We studied 284 patients with HF who were divided into 4 groups based on the median split of NT-proBNP levels and cut point for depressive symptoms (Beck Depression Inventory ≥ 14): (1) low NT-proBNP of 562...
February 13, 2018: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29437599/-malignant-left-ventricular-hypertrophy-identifies-subjects-at-high-risk-for-progression-to-asymptomatic-left-ventricular-dysfunction-heart-failure-and-death-mesa-multi-ethnic-study-of-atherosclerosis
#4
Matthew N Peters, Stephen L Seliger, Robert H Christenson, Susie N Hong-Zohlman, Lori B Daniels, Joao A C Lima, James A de Lemos, Ian J Neeland, Christopher R deFilippi
BACKGROUND: As heart failure (HF)-associated morbidity and mortality continue to escalate, enhanced focus on prevention is increasingly important. "Malignant" left ventricular (LV) hypertrophy (LVH): LVH combined with an elevated cardiac biomarker reflecting either injury (high-sensitivity cardiac troponin T), or strain (amino-terminal pro-B-type natriuretic peptide) has predicted accelerated progression to HF. We sought to determine whether malignant LVH identified community-dwelling adults initially free of cardiovascular disease at high risk of asymptomatic decline in LV ejection fraction or a clinical cardiovascular event...
February 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29436381/subcutaneous-treprostinil-in-congenital-heart-disease-related-pulmonary-arterial-hypertension
#5
Nika Skoro-Sajer, Christian Gerges, Olga Hajnalka Balint, Dora Kohalmi, Monika Kaldararova, Iveta Simkova, Johannes Jakowitsch, Harald Gabriel, Helmut Baumgartner, Mario Gerges, Roela Sadushi-Kolici, David S Celermajer, Irene Marthe Lang
OBJECTIVE: To assess the efficacy and safety of subcutaneous treprostinil in adult patients with congenital heart disease (CHD)-associated pulmonary arterial hypertension (PAH) after 12 months of treatment. METHODS: Consecutive adult patients with CHD-PAH received subcutaneous treprostinil to maximum tolerated doses in an observational study. RESULTS: Advanced CHD-PAH patients with WHO class III or IV disease (n=32, age 40±10 years, 20 females) received treprostinil for suboptimal response to bosentan (n=12), WHO functional class IV disease (FC, n=7) or prior to bosentan approval (n=13)...
February 7, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29435775/quercetin-prevents-in-vivo-and-in-vitro-myocardial-hypertrophy-through-the-proteasome-gsk-3-pathway
#6
Kuixiang Chen, Mubarak Rekep, Wei Wei, Qian Wu, Qin Xue, Sujuan Li, Jiahui Tian, Quan Yi, Genshui Zhang, Guiping Zhang, Qing Xiao, Jiandong Luo, Yinghua Liu
PURPOSE: Quercetin, a flavonoid, has been reported to ameliorate cardiovascular diseases, such as cardiac hypertrophy. However, the mechanism is not completely understood. In this study, a mechanism related to proteasome-glycogen synthesis kinase 3 (GSK-3) was elucidated in rats and primary neonatal cardiomyocytes. METHODS: Rats were subjected to sham or constriction of abdominal aorta surgery groups and treated with or without quercetin for 8 weeks. Angiotensin II (Ang II)-induced primary cardiomyocytes were cultured with quercetin treatment or not for 48 h...
February 12, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29434163/combined-assessment-of-the-red-cell-distribution-width-and-b-type-natriuretic-peptide-a-more-useful-prognostic-marker-of-cardiovascular-mortality-in-heart-failure-patients
#7
Shin Kawasoe, Takuro Kubozono, Satoko Ojima, Masaaki Miyata, Mitsuru Ohishi
Objective An increased red cell distribution width (RDW) has been reported to be associated with adverse outcomes in patients with heart failure (HF). This study aimed to evaluate the prognostic power of the combined measurement of RDW and B-type natriuretic peptide (BNP) concentrations in patients with HF. Methods and Results We retrospectively studied 116 patients (mean age, 63.7±14.3 years) who were admitted for the treatment of HF. Data including demographic information, vital signs, and laboratory and echocardiographic measurements at admission were collected from medical records...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29434126/a-case-of-heart-failure-with-hyperthyroidism-demonstrating-discrepancy-between-the-clinical-course-and-b-type-natriuretic-peptide-levels
#8
Chiaki Kishida, Ryo Naito, Hiroki Kasuya, Tomohiro Kaneko, Kosuke Yabe, Midori Kakihara, Ryosuke Shimai, Hiroyuki Isogai, Dai Ozaki, Yuki Yasuda, Fuminori Odagiri, Tetsuro Miyazaki, Ken Yokoyama, Takashi Tokano, Hajime Koyano, Yuji Nakazato
A 35-year-old Japanese man was emergently admitted to our hospital with chief complaints of palpitation and dyspnea. He has been treated for Basedow's disease. He was diagnosed with acute decompensated heart failure, atrial fibrillation and thyrotoxicosis. We started anti-thyroid agents and a treatment for heart failure with beta blockers and diuretics under anti-coagulation therapy. His B-type natriuretic peptide levels remained high, although the heart failure had been compensated and the heart rate was well controlled while hyperthyroidism still existed...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29432202/plasma-midregional-proadrenomedullin-mr-proadm-concentrations-and-their-biological-determinants-in-a-reference-population
#9
Magdalena Krintus, Marek Kozinski, Federica Braga, Jacek Kubica, Grazyna Sypniewska, Mauro Panteghini
BACKGROUND: Midregional proadrenomedullin (MR-proADM) is emerging as a prognostic biomarker for detecting the failure of multiple organs. Establishment of scientifically robust reference intervals facilitates interpretation of laboratory test results. The objectives of this study were (i) to establish reliable reference intervals for plasma MR-proADM using a commercially available automated fluoroimmunoassay in apparently healthy individuals, and (ii) to identify biological determinants of MR-proADM concentrations...
February 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29431103/interaction-of-body-mass-index-on-the-association-between-n-terminal-pro-b-type-natriuretic-peptide-and-morbidity-and-mortality-in-patients-with-acute-heart-failure-findings-from-ascend-hf-acute-study-of-clinical-effectiveness-of-nesiritide-in-decompensated
#10
Ankeet S Bhatt, Lauren B Cooper, Andrew P Ambrosy, Robert M Clare, Adrian Coles, Emer Joyce, Arun Krishnamoorthy, Javed Butler, G Michael Felker, Justin A Ezekowitz, Paul W Armstrong, Adrian F Hernandez, Christopher M O'Connor, Robert J Mentz
BACKGROUND: Higher body mass index (BMI) is associated with lower circulating levels of N-terminal-pro-b-type natriuretic peptide (NT-proBNP). The Interaction between BMI and NT-proBNP with respect to clinical outcomes is not well characterized in patients with acute heart failure. METHODS AND RESULTS: A total of 686 patients from the biomarker substudy of the ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated HF ) clinical trial with documented NT-proBNP levels at baseline were included in the present analysis...
February 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29428439/using-nt-probnp-for-eligibility-and%C3%A2-enrichment-in-trials-in-hfpef-hfmref-%C3%A2-and-hfref
#11
Gianluigi Savarese, Nicola Orsini, Camilla Hage, Ola Vedin, Francesco Cosentino, Giuseppe M C Rosano, Ulf Dahlström, Lars H Lund
OBJECTIVES: The purpose of this study was to assess the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiovascular (CV) versus non-CV events and between NT-proBNP and potential treatment effects in heart failure (HF) with preserved, mid-range, and reduced ejection fraction (HFpEF, HFmrEF, and HFrEF, respectively) and clinically relevant subgroups. BACKGROUND: Optimizing patient eligibility criteria in HF trials requires biomarkers that enrich for CV but not for non-CV events and select patients most likely to respond to the tested intervention...
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29428236/liver-fibrosis-marker-7s-domain-of-collagen-type-iv-in-patients-with-pre-capillary-pulmonary-hypertension
#12
Akiomi Yoshihisa, Yusuke Kimishima, Takatoyo Kiko, Yu Sato, Shunsuke Watanabe, Yuki Kanno, Satoshi Abe, Makiko Miyata-Tatsumi, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: Pulmonary hypertension (PH) causes right ventricular dysfunction and central venous congestion, and may lead to congestive hepatopathy. The serum 7S domain of collagen type IV (P4NP 7S) is an established marker of liver fibrosis in chronic liver disease. We aimed to determine whether P4NP 7S is related to hemodynamic parameters, and assessed the potential values of P4NP 7S to predict mortality. METHODS: Consecutive 76 pre-capillary PH patients were divided into tertiles based on their serum P4NP 7S levels...
February 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29424571/coronary-microvascular-dysfunction-in-patients-with-heart-failure-with-preserved-ejection-fraction
#13
Kathryn Dryer, Mark Gajjar, Nikhil Narang, Margaret Lee, Jonathan Paul, Atman P Shah, Sandeep Nathan, Javed Butler, Charles J Davidson, William F Fearon, Sanjiv J Shah, John Edward Abellera Blair
BACKGROUND: There are multiple proposed mechanisms for the pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF). We hypothesize that coronary microvascular dysfunction is common in these patients. METHODS AND RESULTS: In a prospective, observational study, patients undergoing cardiac catheterization with HFpEF (left ventricular (LV) ejection fraction {greater than or equal to} 50% and with clinical HF), were compared to similar patients without HFpEF...
February 9, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29424480/predicting-new-onset-hf-in-patients-undergoing-coronary-or-peripheral-angiography-results-from-the-catheter-sampled-blood-archive-in-cardiovascular-diseases-casablanca-study
#14
Nasrien E Ibrahim, Asya Lyass, Hanna K Gaggin, Yuyin Liu, Roland R J van Kimmenade, Shweta R Motiwala, Noreen P Kelly, Parul U Gandhi, Mandy L Simon, Arianna M Belcher, Jamie E Harisiades, Joseph M Massaro, Ralph B D'Agostino, James L Januzzi
AIMS: Methods to identify patients at risk for incident HF would be welcome as such patients might benefit from earlier interventions. METHODS AND RESULTS: From a registry of 1251 patients referred for coronary and/or peripheral angiography, we sought to identify independent predictors of incident HF during follow-up and develop a clinical and biomarker strategy to predict this outcome. There were 991 patients free of prevalent HF at baseline. Cox proportional hazard models were developed to predict adjudicated diagnosis of incident HF...
February 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29417568/n-terminal-b-type-natriuretic-peptide-nt-probnp-is-associated-with-disease-severity-in-multiple-myeloma
#15
Noemi Pavo, Anna Cho, Raphael Wurm, Guido Strunk, Maria Krauth, Hermine Agis, Martin Hülsmann
BACKGROUND: Elevated levels of cardiovascular markers including N-terminal B-type natriuretic peptide (NT-proBNP) have been shown to be associated with disease severity and mortality in an unselected population of cancer patients without cardiac disease. The aim of the present study was to investigate whether NT-proBNP levels are related to disease severity in multiple myeloma (MM) and to assess the natural course of NT-proBNP levels throughout disease progression. MATERIALS AND METHODS: We retrospectively analyzed a total of 118 patients with MM, who were followed-up routinely...
February 8, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29417167/maternal-no2-exposure-induces-cardiac-hypertrophy-in-male-offspring-via-ros-hif-1%C3%AE-transcriptional-regulation-and-aberrant-dna-methylation-modification-of-csx-nkx2-5
#16
Yingying Zhang, Wei Yan, Xiaotong Ji, Huifeng Yue, Guangke Li, Nan Sang
Maternal exposure to nitrogen dioxide (NO2) poses a risk for morbidity and mortality in infantile congenital heart diseases and even adult cardiovascular diseases. However, the experimental evidence supporting these effects is insufficient, and the related regulatory mechanisms are unknown. In the present study, we aimed to determine whether maternal NO2 exposure causes cardiac hypertrophy-related consequences in offspring, and if so, how these adverse effects occur in the postnatal heart. The results indicate that in mice, maternal NO2 exposure causes cardiac hypertrophy in male offspring...
February 7, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29408981/excessive-adiposity-and-metabolic-dysfunction-relate-to-reduced-natriuretic-peptide-during-raas-activation-in-hiv
#17
Caitlin A Murphy, Kathleen V Fitch, Meghan Feldpausch, Patrick Maehler, Kimberly Wong, Martin Torriani, Gail K Adler, Steven K Grinspoon, Suman Srinivasa
Purpose: Natriuretic peptides (NPs) negatively feedback on the renin-angiotensin-aldosterone system (RAAS) and play a critical role in preserving cardiac structure and maintaining metabolic homeostasis. Well-treated HIV-infected individuals are at risk for fat redistribution and demonstrate evidence of RAAS dysregulation, which relates to metabolic dysfunction. We investigated circulating NPs in relation to RAAS physiology and metrics of body composition for the first time in HIV. Methods: We assessed atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and amino terminal pro B-type natriuretic peptide (NT-proBNP) during acute activation of the RAAS using a low sodium controlled diet among 20 HIV-infected and 10 non-HIV-infected individuals well-phenotyped for body composition...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29408167/predicting-cardiogenic-pulmonary-edema-in-heart-failure-patients-by-using-an-n-terminal-pro-b-type-natriuretic-peptide-nt-pro-bnp-based-score
#18
Xin-Yi Liu, Ya-Ting Huang, Min-Yu Lai, John Chen, Tung-Wei Chu, Pei-Kwei Tasy, Chih-Chung Shiao
BACKGROUND: Cardiogenic pulmonary edema (CPE) is a life-threatening emergency necessitating aggressive management. We conducted this study to test the hypothesis that a combination of N-terminal pro-b-type natriuretic peptide (NT-pro-BNP) and some relevant clinical factors may provide better predictability for CPE in heart failure (HF) patients. METHODS: This retrospective study enrolled adult HF patients hospitalized during January 2011 to December 2013. After determining the independent predictors for the occurrence of CPE, a novel NT-pro BNP-based diagnostic score for predicting CPE was established...
January 27, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29405611/efficacy-and-safety-of-intermittent-intravenous-outpatient-administration-of-levosimendan-in-patients-with-advanced-heart-failure-the-lion-heart-multicentre-randomised-trial
#19
Josep Comín-Colet, Nicolás Manito, Javier Segovia-Cubero, Juan Delgado, José Manuel García Pinilla, Luis Almenar, María G Crespo-Leiro, Alessandro Sionis, Teresa Blasco, Domingo Pascual-Figal, Francisco Gonzalez-Vilchez, José Luis Lambert-Rodríguez, María Grau, Jordi Bruguera
AIMS: The LION-HEART study was a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial evaluating the efficacy and safety of intravenous administration of intermittent doses of levosimendan in outpatients with advanced chronic heart failure. METHODS AND RESULTS: Sixty-nine patients from 12 centres were randomly assigned at a 2:1 ratio to levosimendan or placebo groups, receiving treatment by a 6-hour intravenous infusion (0.2 μg/kg/min without bolus) every 2 weeks for 12 weeks...
February 6, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29405554/six-month-outcome-after-transcatheter-edge-to-edge-repair-of-severe-tricuspid-regurgitation-in-patients-with-heart-failure
#20
Mathias Orban, Christian Besler, Daniel Braun, Michael Nabauer, Marion Zimmer, Martin Orban, Thilo Noack, Julinda Mehilli, Christian Hagl, Joerg Seeburger, Michael Borger, Axel Linke, Holger Thiele, Steffen Massberg, Joerg Ender, Philipp Lurz, Jörg Hausleiter
AIMS: Severe tricuspid regurgitation (TR) is common in patients with right-sided heart failure (HF) and causes substantial morbidity and mortality. Treatment options beyond medical therapy are limited for high-risk patients. Transcatheter edge-to-edge tricuspid valve (TV) repair showed procedural safety and short-term efficacy. Impact on mid-term outcome is unclear. This dual-centre observational study evaluates the mid-term safety, efficacy and clinical outcome after edge-to-edge TV repair for severe TR in patients with HF...
February 6, 2018: European Journal of Heart Failure
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