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b type natriuretic peptide

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https://www.readbyqxmd.com/read/28318874/metabolic-profile-provides-prognostic-value-better-than-galectin-3-in-patients-with-heart-failure
#1
Chao-Hung Wang, Mei-Ling Cheng, Min-Hui Liu, Li-Tang Kuo, Ming-Shi Shiao
BACKGROUND: Metabolic profiles have been shown to provide prognostic information in patients with heart failure (HF). Galectin-3 (Gal-3), indicating cardiac fibrosis, is a documented biomarker of prognosis in HF. It is unknown whether metabolic profiles provide prognostic value better than Gal-3. METHODS AND RESULTS: This study analyzed 212 hospitalized HF patients, measuring metabolic score (composed by butyrylcarnitine, dimethylarginine/arginine ratio, spermidine, and total essential amino acids) and Gal-3...
March 16, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28316101/n-terminal-pro-b-type-natriuretic-peptide-and-phonocardiography-in-differentiating-innocent-cardiac-murmurs-from-congenital-cardiac-anomalies-in-asymptomatic-puppies
#2
S M Marinus, H van Engelen, V Szatmári
BACKGROUND: Differentiating innocent cardiac murmurs from murmurs caused by congenital cardiac anomalies can be challenging with auscultation alone in asymptomatic puppies. HYPOTHESIS: Plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations and phonocardiograms recorded by an electronic stethoscope can differentiate innocent from pathologic cardiac murmurs. ANIMALS: A total of 186 client-owned asymptomatic dogs: 135 Cairn Terriers (age: 45-124 days), 20 adult Cairn Terriers (age: 7...
March 18, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28315120/prognostic-biomarkers-in-acute-coronary-syndromes-risk-stratification-beyond-cardiac-troponins
#3
REVIEW
K M Eggers, B Lindahl
PURPOSE OF REVIEW: Cardiac troponin (cTn) plays an essential role for assessment of outcome in acute coronary syndrome (ACS). However, the prognostic value of cTn is not absolute. In this mini-review, we summarize the evidence on the utility of established biomarkers of left-ventricular dysfunction, hemodynamic stress, inflammation, and renal dysfunction for risk prediction beyond cTn in ACS. RECENT FINDINGS: Only few biomarkers consistently demonstrate additive prognostic value to cTn levels...
April 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28314078/high-physical-fitness-is-associated-with-reduction-in-basal-and-exercise-induced-inflammation
#4
Øyunn Kleiven, Magnus Bjørkavoll-Bergseth, Tor Melberg, Øyvind Skadberg, Rolf Bergseth, Jone Selvåg, Bjørn Auestad, Pål Aukrust, Torbjørn Aarsland, Stein Ørn
C-reactive protein (CRP) increases after strenuous exercise. It has been a concern that prolonged strenuous exercise may be harmful, and induce a deleterious inflammatory response. The purpose of this study was to 1) Assess and quantify the magnitude of CRP response following an endurance cycling competition in healthy middle-aged recreational cyclists. 2) Identify important determinants of this response. 3) Identify the relationship between CRP, myocardial damage (cardiac Troponin I (cTnI)) and myocardial strain (B-type natriuretic peptide (BNP))...
March 17, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28306696/n-terminal-fragment-of-b-type-natriuretic-peptide-predicts-coexisting-subclinical-heart-and-vessel-disease
#5
Luigi E Pastormerlo, Stefano Maffei, Daniele Della Latta, Vladislav Chubuchny, Carla Susini, Sergio Berti, Concetta Prontera, Simona Storti, Claudio Passino, Emilio Pasanisi, Michele Emdin, Dante Chiappino
BACKGROUND: Identification of preclinical cardiovascular disease represents a challenge. We evaluate N-terminal proB-type natriuretic peptides (NT-proBNP) as markers of both cardiac and vascular subclinical disease in a community-based study including asymptomatic middle- aged study participants. METHODS AND RESULTS: In total, 807 study participants without previous cardiovascular disease were recruited. They underwent thorough laboratory assessment (including NT-proBNP), ultrasound examination of heart and evaluation of coronary calcium score and carotid intima-media thickness, by computed tomography and ultrasound, respectively...
March 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28302926/long-term-effect-of-sildenafil-on-echocardiographic-parameters-in-dogs-with-asymptomatic-myxomatous-mitral-valve-degeneration
#6
Anusak Kijtawornrat, Siripen Komolvanich, Nakkawee Saengklub, Prapawadee Pirintr, Pakit Boonpala, Chollada Buranakarl
Sildenafil is a selective phosphodiesterase-5 inhibitor that has been demonstrated to delay ventricular remodeling in humans and experimental animals. The aim of this prospective study was to assess the chronic effects of sildenafil administration on echocardiographic indices and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in dogs with naturally occurring, asymptomatic myxomatous mitral valve degeneration. Thirty client-owned dogs with ACVIM class B1 or B2 were enrolled. Dogs were randomly assigned to treatment (sildenafil 1-3 mg/kg, PO, BID for 180 days) or control groups...
March 11, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28299572/early-weight-loss-independent-effects-of-sleeve-gastrectomy-on-diet-induced-cardiac-dysfunction-in-obese-wistar-rats
#7
Tammy L Kindel, Tom Foster, Paul Goldspink, Steven J Kindel, John Corbett, Michael Widlanksy, Jennifer Strande
INTRODUCTION: Several reports suggest that bariatric surgery significantly improves cardiac function in patients with obesity cardiomyopathy. The mechanism is unknown but may be due to weight-loss independent factors. We predict that the changes in gastrointestinal anatomy after a rodent model of sleeve gastrectomy (SG) will have weight-loss independent effects on cardiac dysfunction. METHODOLOGY: Cardiac dysfunction was induced by feeding a 60% kcal from fat diet to male Wistar rats for 10 weeks...
March 15, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28296139/measurement-of-troponin-and-natriuretic-peptides-shortly-after-admission-in-patients-with-heart-failure-does-it-add-useful-prognostic-information-an-analysis-of-the-value-of-endothelin-receptor-inhibition-with-tezosentan-in-acute-heart-failure-studies-veritas
#8
John G F Cleland, John R Teerlink, Beth A Davison, Ahmad Shoaib, Marco Metra, Stefanie Senger, Olga Milo, Gad Cotter, Robert C Bourge, John D Parker, Guillaume Jondeau, Henry Krum, Christopher M O'Connor, Guillermo Torre-Amione, Dirk J van Veldhuisen, John J V McMurray
OBJECTIVE: Plasma concentrations of B-type natriuretic peptide (BNP) and troponin are often measured for diagnostic purposes when patients are admitted with heart failure, but their prognostic value when measured soon after admission is uncertain. We aimed to investigate the added prognostic value of admission measurements of BNP and troponins in patients with acute heart failure. METHODS AND RESULTS: Multivariable prognostic models for death or any worsening heart failure (WHF) or rehospitalization for WHF by 30 days, 30-day death or rehospitalization for WHF, and 90-day mortality were constructed using baseline data from the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS) including BNP and troponin I...
March 10, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28295985/heart-failure-with-mid-range-ejection-fraction-a-distinct-clinical-entity-insights-from-the-trial-of-intensified-versus-standard-medical-therapy-in-elderly-patients-with-congestive-heart-failure-time-chf
#9
Peter Rickenbacher, Beat A Kaufmann, Micha T Maeder, Alain Bernheim, Kaatje Goetschalckx, Otmar Pfister, Matthias Pfisterer, Hans-Peter Brunner-La Rocca
AIMS: While the conditions of heart failure (HF) with reduced (HFrEF, LVEF < 40%) and preserved (HFpEF, LVEF ≥ 50%) left ventricular ejection fraction (LVEF) are well characterized, it is unknown whether patients with HF and mid-range LVEF (HFmrEF, LVEF 40-49%) have to be regarded as a separate clinical entity. The aim of this study was to characterize these three populations and to compare outcome and response to therapy. METHODS AND RESULTS: The analysis was based on the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF) comprising a population with established HF including the whole spectrum of LVEF...
March 15, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28295946/feasibility-and-interpretation-of-global-longitudinal-strain-imaging-in-pediatric-heart-transplant-recipients
#10
Bethany L Wisotzkey, Neal W Jorgensen, Erin L Albers, Mariska S Kemna, Robert J Boucek, Richard A Kronmal, Yuk M Law, Aarti H Bhat
Evaluation of myocardial mechanics after heart transplant is important in monitoring allograft function and identifying rejection. Speckle tracking global longitudinal strain (GLS) may be more sensitive to early regional changes from rejection. This study aimed to determine feasibility of GLS in pediatric hearts during surveillance echocardiograms, compare their GLS to published norms (-18% to -22%), and assess association of GLS with other indices of graft function. Retrospective review of transplant echocardiograms from 2013 to 2014...
March 10, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28285713/relation-of-red-cell-distribution-width-to-left-ventricular-end-diastolic-pressure-and-mortality-in-patients-with-and-without-heart-failure
#11
Vichai Senthong, Timothy Hudec, Sarah Neale, Yuping Wu, Stanley L Hazen, W H Wilson Tang
Higher red cell distribution width (RDW) has been associated with poor prognosis in patients with heart failure (HF). RDW is also closely associated with iron deficiency. However, the mechanism underlying this association is unclear. The relation between left ventricular end-diastolic pressure (LVEDP) and RDW has not been studied, especially in those without HF. We examined the relation between LVEDP and RDW in 1,084 consecutive stable patients who underwent elective coronary angiography. We observed that 38% had high LVEDP (>16 mm Hg) and 29% had history of HF...
February 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28282683/-indications-and-clinical-implications-of-the-use-of-the-cardiac-markers-bnp-and-nt-probnp
#12
Andreas Luchner, Stephan von Haehling, Christian Holubarsch, Till Keller, Fabian Knebel, Christian Zugck, Ulrich Laufs
B-type natriuretic peptides are markers of myocardial wall stress. BNP or NT-proBNP are used for the differential diagnosis of acute dyspnoe where normal serum concentrations make a cardiac cause unlikely. New data show their importance for risk prediction in different stages of heart failure and in primary prevention. Natriuretic peptide guided therapy improves titration of heart failure medications. Compared to BNP, NT-proBNP is better suited during therapy with the new angiotensin-rezeptor-neprilysin-inhibitor Sacubitril/Valsartan...
March 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28279654/bloodstream-amyloid-beta-1-40-peptide-cognition-and-outcomes-in-heart-failure
#13
Antoni Bayes-Genis, Jaume Barallat, Marta de Antonio, Mar Domingo, Elisabet Zamora, Joan Vila, Isaac Subirana, Paloma Gastelurrutia, M Cruz Pastor, James L Januzzi, Josep Lupón
INTRODUCTION AND OBJECTIVES: In the brain, amyloid-beta generation participates in the pathophysiology of cognitive disorders; in the bloodstream, the role of amyloid-beta is uncertain but may be linked to sterile inflammation and senescence. We explored the relationship between blood levels of amyloid-beta 1-40 peptide (Aβ40), cognition, and mortality (all-cause, cardiovascular, and heart failure [HF]-related) in ambulatory patients with HF. METHODS: Bloodstream Aβ40 was measured in 939 consecutive patients with HF...
March 6, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28275418/sex-differences-of-the-natriuretic-peptide-polymorphism-associated-with-angiographic-coronary-atherosclerosis
#14
Terry Y Li, M Yat Tse, Stephen C Pang, Catherine S McLellan, Will D King, Amer M Johri
BACKGROUND: Polymorphisms within natriuretic peptide (NP) genes have been associated with clinical outcomes for cardiovascular disease (CVD), but no previous study has compared the effect of these polymorphisms between men and women. This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) in key genes of the NP system and coronary angiographic outcomes, with the focus on the sexual dimorphism in the effects of these SNPs. METHODS: Patients undergoing clinically indicated coronary angiography (n = 513, 328 men and 185 women) were consented and genotyped for NPPA rs5065, NPPB rs198389 and NPR2 rs10758325...
February 2017: Cardiology Research
https://www.readbyqxmd.com/read/28272348/zinc-prevents-the-development-of-diabetic-cardiomyopathy-in-db-db-mice
#15
Shudong Wang, Bowei Wang, Yuehui Wang, Qian Tong, Quan Liu, Jian Sun, Yang Zheng, Lu Cai
Diabetic cardiomyopathy (DCM) is highly prevalent in type 2 diabetes (T2DM) patients. Zinc is an important essential trace metal, whose deficiency is associated with various chronic ailments, including vascular diseases. We assessed T2DM B6.BKS(D)-Leprdb/J (db/db) mice fed for six months on a normal diet containing three zinc levels (deficient, adequate, and supplemented), to explore the role of zinc in DCM development and progression. Cardiac function, reflected by ejection fraction, was significantly decreased, along with increased left ventricle mass and heart weight to tibial length ratio, in db/db mice...
March 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28271683/clinical-value-of-combined-detection-of-ck-mb-myo-ctni-and-plasma-nt-probnp-in-diagnosis-of-acute-myocardial-infarction
#16
Jiubo Fan, Ji Ma, Ning Xia, Li Sun, Baoan Li, Haiju Liu
BACKGROUND: Acute myocardial infarction (AMI) is a serious life-threatening and common heart disease that is based on coronary atherosclerosis. The aim is to study the changes in the level of kinase isoenzyme (CK-MB), myoglobin (MYO), cardiac troponin I (cTnI), and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with acute myocardial infarction (AMI) and the four indicators of joint detection clinical value for diagnosis of AMI. METHODS: Plasma NT-proBNP, CK-MB, MYO, and cTnI were detected by CLIA in 208 AMI patients (AMI group) and 115 non-AMI patients (control group)...
March 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28268084/the-impact-of-time-to-heart-failure-diagnosis-on-outcomes-in-patients-tailored-for-heart-failure-treatment-by-use-of-natriuretic-peptides-results-from-the-upstep-study
#17
Patric Karlström, Peter Johansson, Ulf Dahlström, Kurt Boman, Urban Alehagen
BACKGROUND: Heart failure (HF) is a life-threatening condition and optimal handling is necessary to reduce risk of therapy failure. The impact of the duration of HF diagnosis on HF outcome has not previously been examined. The objectives of this study were (I) to evaluate the impact of patient age on clinical outcomes, (II) to evaluate the impact of duration of the HF disease on outcomes, and (III) to evaluate the impact of age and HF duration on B-type Natriuretic Peptide (BNP) concentration in a population of HF patients...
February 17, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28267463/early-inpatient-calculation-of-laboratory-based-30-day-readmission-risk-scores-empowers-clinical-risk-modification-during-index-hospitalization
#18
Benjamin D Horne, Deborah Budge, Andrew L Masica, Lucy A Savitz, José Benuzillo, Gabriela Cantu, Alejandra Bradshaw, Raymond O McCubrey, Tami L Bair, Colleen A Roberts, Kismet D Rasmusson, Rami Alharethi, Abdallah G Kfoury, Brent C James, Donald L Lappé
Improving 30-day readmission continues to be problematic for most hospitals. This study reports the creation and validation of sex-specific inpatient (i) heart failure (HF) risk scores using electronic data from the beginning of inpatient care for effective and efficient prediction of 30-day readmission risk. METHODS: HF patients hospitalized at Intermountain Healthcare from 2005 to 2012 (derivation: n=6079; validation: n=2663) and Baylor Scott & White Health (North Region) from 2005 to 2013 (validation: n=5162) were studied...
March 2017: American Heart Journal
https://www.readbyqxmd.com/read/28266662/clinical-correlates-of-b-type-natriuretic-peptide-monitoring-in-outpatients-with-left-ventricular-assist-device
#19
Marketa Hegarova, Milos Kubanek, Ivan Netuka, Jiri Maly, Zora Dorazilova, Tomas Gazdic, Janka Franekova, Vera Lanska, Vojtech Melenovsky, Josef Kautzner, Ivan Malek
BACKGROUND: B-type natriuretic peptide (BNP) is a strong predictor of prognosis in chronic heart failure. We aimed to evaluate the clinical correlates and interpretation of BNP monitoring in LVAD out-patient recipients. METHODS: We performed a prospective study in 136 individuals after HeartMate II LVAD implantation. During follow-up they were divided into group A (severe adverse events requiring hospitalisation), group B (mild to moderate adverse events) and group C (an uneventful course)...
February 27, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28265228/echocardiography-and-cardiac-biomarkers-in-patients-with-non-small-cell-lung-cancer-treated-with-platinum-based-chemotherapy
#20
Daniel Omersa, Tanja Cufer, Robert Marcun, Mitja Lainscak
BACKGROUND: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and remains an important cause of cancer death worldwide. Platinum-based chemotherapy (PBC) for NSCLC can modify outcome while the risk of cardiotoxicity remains poorly researched. We aimed to evaluate the incidence and severity of cardiac injury during PBC in patients with NSCLC and to identify patients at risk. METHODS: This was a single-centre, prospective, observational study of patients with early and advanced stage NSCLC referred for PBC...
March 1, 2017: Radiology and Oncology
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