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b type natriuretic peptide

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https://www.readbyqxmd.com/read/29242240/persistence-of-infarct-zone-t2-hyperintensity-at-6-months-after-acute-st-segment-elevation-myocardial-infarction-incidence-pathophysiology-and-prognostic-implications
#1
Jaclyn Carberry, David Carrick, Caroline Haig, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
BACKGROUND: The incidence and clinical significance of persistent T2 hyperintensity after acute ST-segment-elevation myocardial infarction (STEMI) is uncertain. METHODS AND RESULTS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI: NCT02072850). Two hundred eighty-three STEMI patients (mean age, 59±12 years; 75% male) had cardiac magnetic resonance with T2 mapping performed at 2 days and 6 months post-STEMI. Persisting T2 hyperintensity was defined as infarct T2 >2 SDs from remote T2 at 6 months...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29241718/ses-heart-failure-and-n-terminal-pro-b-type-natriuretic-peptide-the-atherosclerosis-risk-in-communities-study
#2
Priya Vart, Kunihiro Matsushita, Andreea M Rawlings, Elizabeth Selvin, Deidra C Crews, Chiadi E Ndumele, Christie M Ballantyne, Gerardo Heiss, Anna Kucharska-Newton, Moyses Szklo, Josef Coresh
INTRODUCTION: Compared with coronary heart disease and stroke, the association between SES and the risk of heart failure is less well understood. METHODS: In 12,646 participants of the Atherosclerosis Risk in Communities Study cohort free of heart failure history at baseline (1987-1989), the association of income, educational attainment, and area deprivation index with subsequent heart failure-related hospitalization or death was examined while accounting for cardiovascular disease risk factors and healthcare access...
December 11, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29241303/body-fluid-status-assessment-by-bio-impedance-analysis-in-patients-presenting-to-the-emergency-department-with-dyspnea
#3
Chan Soon Park, Sang-Eun Lee, Hyun-Jai Cho, Yong-Jin Kim, Hyun-Jae Kang, Byung-Hee Oh, Hae-Young Lee
Background/Aims: Fluid retention occurs in patients with heart failure, accounting for dyspnea. We investigated the diagnostic implication of body fluid status, assessed by bio-impedance analysis (BIA), in acute heart failure (AHF) among patients who presented with dyspnea. Methods: A total of 100 patients who presented with dyspnea and suspected with AHF were analyzed in this study. We enrolled 50 AHF and 50 non-AHF patients discriminated through echocardiographic analysis and Framingham criteria and were matched by age and sex...
December 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29239515/rationale-and-design-of-transition-a-randomized-trial-of-pre-discharge-vs-post-discharge-initiation-of-sacubitril-valsartan
#4
Domingo Pascual-Figal, Rolf Wachter, Michele Senni, Jan Belohlavek, Adele Noè, David Carr, Dmytro Butylin
AIMS: The prognosis after hospitalization for acute decompensated heart failure (ADHF) remains poor, especially <30 days post-discharge. Evidence-based medications with prognostic impact administered at discharge improve survival and hospital readmission, but robust studies comparing pre-discharge with post-discharge initiation are rare. The PARADIGM-HF trial established sacubitril/valsartan as a new evidence-based therapy in patients with heart failure (HF) and reduced left ventricular ejection fraction (<40%) (rEF)...
December 14, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29237677/genome-wide-association-study-implicates-atrial-natriuretic-peptide-rather-than-b-type-natriuretic-peptide-in-the-regulation-of-blood-pressure-in-the-general-population
#5
Perttu P Salo, Aki S Havulinna, Taru Tukiainen, Olli Raitakari, Terho Lehtimäki, Mika Kähönen, Johannes Kettunen, Minna Männikkö, Johan G Eriksson, Antti Jula, Stefan Blankenberg, Tanja Zeller, Veikko Salomaa, Kati Kristiansson, Markus Perola
BACKGROUND: Cardiomyocytes secrete atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in response to mechanical stretching, making them useful clinical biomarkers of cardiac stress. Both human and animal studies indicate a role for ANP as a regulator of blood pressure with conflicting results for BNP. METHODS AND RESULTS: We used genome-wide association analysis (n=6296) to study the effects of genetic variants on circulating natriuretic peptide concentrations and compared the impact of natriuretic peptide-associated genetic variants on blood pressure (n=27 059)...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29237455/molecular-and-histological-effects-of-mr-guided-pulsed-focused-ultrasound-to-the-rat-heart
#6
Kee W Jang, Tsang-Wei Tu, Matthew E Nagle, Bobbi K Lewis, Scott R Burks, Joseph A Frank
BACKGROUND: Image-guided high intensity focused ultrasound has been used as an extracorporeal cardiac pacing tool and to enhance homing of stem cells to targeted tissues. However, molecular changes in the myocardium after sonication have not been widely investigated. Magnetic-resonance (MR)-guided pulsed focused ultrasound (pFUS) was targeted to the rat myocardium over a range of pressures and the microenvironmental and histological effects were evaluated over time. METHODS: Eight-to-ten-week-old Sprague-Dawley rats received T2-weighted MR images to target pFUS to the left ventricular and septum without cardiac or respiratory gating...
December 13, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29227899/cardiac-troponins-and-nt-probnp-in-the-forensic-setting-overview-of-sampling-site-postmortem-interval-cardiopulmonary-resuscitation-and-review-of-the-literature
#7
Cristian Palmiere, Camilla Tettamanti, Alessandro Bonsignore, Francesco De Stefano, Jessica Vanhaebost, Guillaume Rousseau, Maria Pia Scarpelli, Daniel Bardy
The possible use of biochemical markers in the postmortem diagnosis of myocardial ischemia is well known in the forensic setting, though several issues have limited its widespread adoption. The study presented herein focuses of N-terminal pro-B-type natriuretic peptide, troponin T, and troponin I, and the possible influence due to sampling site chosen, postmortem interval elapsed, and cardiopulmonary resuscitation attempts. Comparisons were performed between antemortem serum levels of these markers and postmortem levels measured in pericardial fluid and postmortem serum samples obtained from different sampling sites (n=16)...
November 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29227092/a-sandwich-type-electrochemiluminescence-sensor-for-detection-of-nt-probnp-by-using-high-efficiency-quench-strategy-of-fe3o4-pda-toward-ru-bpy-32-coordinated-with-silver-oxalate
#8
Li Shi, Xiaojian Li, Wenjuan Zhu, Yaoguang Wang, Bin Du, Wei Cao, Qin Wei, Xuehui Pang
Heart failure (HF) is a burgeoning public health problems trigged by heart circulation disorder. N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been acknowledged as a prognostic biomarker for cardiac disease. Herein, a sandwich-type electrochemiluminescence (ECL) immunosensor was introduced for sensitive detection of NT-proBNP. Gold nanoparticles modified graphene oxide-Ru(bpy)32+/Ag2C2O4 was used as luminophore and desirable platform for immobilization of the capture antibodies. The more stable immobilization of plentiful Ru(bpy)32+ could be implemented by direct covalently-bonded chelating with Ag2C2O4...
December 11, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29226610/nuclear-magnetic-resonance-based-metabolomics-identifies-phenylalanine-as-a-novel-predictor-of-incident-heart-failure-hospitalisation-results-from-prosper-and-finrisk-1997
#9
Christian Delles, Naomi J Rankin, Charles Boachie, Alex McConnachie, Ian Ford, Antti Kangas, Pasi Soininen, Stella Trompet, Simon P Mooijaart, J Wouter Jukema, Faiez Zannad, Mika Ala-Korpela, Veikko Salomaa, Aki S Havulinna, Paul Welsh, Peter Würtz, Naveed Sattar
AIMS: We investigated the association between quantified metabolite, lipid and lipoprotein measures and incident heart failure hospitalisation (HFH) in the elderly, and examined whether circulating metabolic measures improve HFH prediction. METHODS AND RESULTS: Overall, 80 metabolic measures from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial were measured by proton nuclear magnetic resonance spectroscopy (n = 5341; 182 HFH events during 2...
December 11, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29226471/a-human-study-to-evaluate-safety-tolerability-and-cyclic-gmp-activating-properties-of-cenderitide-in-subjects-with-stable-chronic-heart-failure
#10
Rika Kawakami, Candace Y W Lee, Christopher Scott, Kent R Bailey, John A Schirger, Horng H Chen, Sherry L Benike, Valentina Cannone, Fernando L Martin, S Jeson Sangaralingham, Tomoko Ichiki, John C Burnett
Cenderitide is a novel designer natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide was engineered to co-activate the two NP receptors, particulate guanylyl cyclase (pGC)-A and -B. The rationale for its design was to achieve the renal-enhancing and anti-fibrotic properties of dual receptor activation, but without clinically significant hypotension. Here, we report the first clinical trial on the safety, tolerability and cyclic guanosine monophosphate (cGMP) activating properties of Cenderitide in subjects with stable HF...
December 11, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29225105/interpretation-of-b-type-natriuretic-peptides-in-the-era-of-angiotensin-receptor-neprilysin-inhibitors
#11
Paulo Bettencourt, Cândida Fonseca, Fátima Franco, Aurora Andrade, Dulce Brito
Assessment of serum levels of natriuretic peptides, especially the amino-terminal portion (NT-proBNP) and the carboxy-terminal portion (BNP) of pro-B-type natriuretic peptide, has had a highly significant clinical impact on the diagnosis and prognostic stratification of patients with heart failure (HF). They are now an instrument with recognized value in this context and several studies have demonstrated their value in tailoring therapy for these patients. Following the recent advent of angiotensin receptor-neprilysin inhibitors (ARNIs), there is a need to review how these two biomarkers are interpreted in HF...
December 7, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29222133/gdf-15-growth-differentiation-factor-15-is-associated-with-lack-of-ventricular-recovery-and-mortality-after-transcatheter-aortic-valve-replacement
#12
Juyong Brian Kim, Yukari Kobayashi, Kegan J Moneghetti, Daniel A Brenner, Ryan O'Malley, Ingela Schnittger, Joseph C Wu, Gillian Murtagh, Agim Beshiri, Michael Fischbein, D Craig Miller, David Liang, Alan C Yeung, Francois Haddad, William F Fearon
BACKGROUND: Recent data suggest that circulating biomarkers may predict outcome in patients undergoing transcatheter aortic valve replacement (TAVR). We examined the association between inflammatory, myocardial, and renal biomarkers and their role in ventricular recovery and outcome after TAVR. METHODS AND RESULTS: A total of 112 subjects undergoing TAVR were included in the prospective registry. Plasma levels of B-type natriuretic peptide, hs-TnI (high-sensitivity troponin I), CRP (C-reactive protein), GDF-15 (growth differentiation factor 15), GAL-3 (galectin-3), and Cys-C (cystatin-C) were assessed before TAVR and in 100 sex-matched healthy controls...
December 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29214898/bio-width-index-a-novel-biomarker-for-prognostication-of-long-term-outcomes-in-patients-with-anaemia-and-heart-failure
#13
Muthiah Subramanian, Mukund A Prabhu, Selva Saravanan, Rajesh Thachathodiyl
BACKGROUND: The utility of biomarkers for prognostication of long term outcomes in patients with anaemia and heart failure(HF) is not well defined. The objective of this study was to assess the ability of a novel biomarker, bio-width index (BWI),to improve risk stratification in patients with anaemia and acutely decompensated heart failure(ADHF), in comparison to conventional markers, B-type natriuretic peptide(BNP) and red- cell distribution width(RDW). METHODS: Data from 1569 consecutive patients with ADHF treated at a multidisciplinary HF unit was analysed in this study...
December 7, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29207933/prognostic-factors-for-in-hospital-mortality-of-patients-hospitalized-for-acutely-decompensated-heart-failure
#14
Štefica Dvornik, Teodora Zaninović Jurjević, Nikolina Jurjević, Amalija Lekić, Luka Zaputović
Objectives Despite improved treatment during last 20 years, prognosis for patients hospitalized for acutely decompensated heart failure (ADHF) is poor and mortality rates reported for these patients are high. Laboratory results can assist clinicians in evaluation and triaging of patients on hospital admission, and are important for the medical decision-making and prognosis assessments. Recently, new guidelines for the diagnosis and treatment of acute and chronic HF patients were published introducing a new group of patients with mid-range left ventricular ejection fraction (LVEF)...
December 5, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29203160/myocardial-strain-may-predict-exercise-tolerance-in-patients-with-reduced-and-mid-range-ejection-fraction
#15
Elias Tsougos, George Angelidis, Elias Gialafos, Chara Tzavara, Vaios Tzifos, Ioannis Tsougos, Panagiotis Georgoulias
BACKGROUND: Conventional echocardiographic parameters, such as rest ejection fraction, perform poorly regarding the prediction of exercise tolerance in heart failure. The aim of the present study was to evaluate the contribution of hemodynamic instability in the observed lower functional capacity, investigating the role of left ventricular strain for the prediction of stress test duration in obese hypertensive patients with reduced ejection fraction. METHODS: Sixty-one patients with reduced ejection fraction underwent treadmill exercise echocardiography...
December 1, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29200908/ursolic-acid-supplementation-decreases-markers-of-skeletal-muscle-damage-during-resistance-training-in-resistance-trained-men-a-pilot-study
#16
Hyun Seok Bang, Dae Yun Seo, Young Min Chung, Do Hyung Kim, Sam-Jun Lee, Sung Ryul Lee, Hyo-Bum Kwak, Tae Nyun Kim, Min Kim, Kyoung-Mo Oh, Young Jin Son, Sanghyun Kim, Jin Han
Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial effects on exercise-induced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group)...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29197871/carvedilol-and-cardiac-biomarkers-in-dialysis-patients-secondary-analysis-of-a-randomized-controlled-trial
#17
Matthew A Roberts, Darsy Darssan, Sunil V Badve, Robert P Carroll, Magid A Fahim, Brian A Haluska, Carmel M Hawley, Nicole M Isbel, Mark R Marshall, Elaine M Pascoe, Eugenie Pedagogos, Helen L Pilmore, Paul Snelling, Tony Stanton, Ken-Soon Tan, Andrew M Tonkin, Liza A Vergara, Francesco L Ierino
BACKGROUND/AIMS: Cardiac biomarkers are associated with cardiac abnormalities and adverse outcomes in dialysis patients. Our aim was to report the effect of the beta-blocker carvedilol on cardiac biomarkers in adult dialysis patients. METHODS: The Beta-Blocker to Lower Cardiovascular Dialysis Events Feasibility Study was a randomized controlled trial comparing carvedilol to placebo. Serum and plasma were collected before the run-in, then 6 and 12 months post-randomization to measure B-type Natriuretic Peptide (BNP), N-terminal BNP (NT-ProBNP), high-sensitivity cardiac troponins I (hs-TnI) and T (hs-TnT), and galectin-3...
December 4, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29197094/plasma-nt-probnp-and-cell-free-dna-concentrations-after-prolonged-strenuous-exercise-in-working-farm-dogs
#18
H Hunt, N Cave, J Bridges, K Gedye, K Hill
BACKGROUND: Plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration is increased in dogs with myocardial dysfunction, and cell-free DNA (cfDNA) increases in numerous disease states. In humans, both of these biomarkers can be altered after endurance exercise. OBJECTIVE: To investigate the effect of prolonged strenuous exercise on circulating NT-proBNP and cfDNA concentrations in working farm dogs. ANIMALS: Six healthy, privately owned working farm dogs (4 Huntaways and 2 heading dogs) from the same hill country farm in New Zealand...
December 2, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29196781/acute-pulmonary-vasodilator-testing-and-long-term-clinical-course-in-segmental-pulmonary-vascular-disease
#19
Liezl Domingo, H Sonali Magdo, Ronald W Day
Results of acute pulmonary vasodilator testing (AVT) and the outcome of medical therapy have not been described in patients with segmental pulmonary vascular disease (SPVD). We sought to compare the pulmonary vasodilatory effects of oxygen, oxygen with nitric oxide, and diltiazem, and to describe the clinical course of patients with SPVD and pulmonary hypertension. A retrospective review of 16 patients with pulmonary hypertension and SPVD involving 2-3 major lung segments who underwent AVT between January 2000 and December 2015 was performed...
December 1, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29194762/cholinesterase-levels-predict-exercise-capacity-in-cardiac-recipients-early-after-transplantation
#20
Kazufumi Kitagaki, Michio Nakanishi, Rei Ono, Kazuya Yamamoto, Yuji Suzuki, Noriyuki Fukui, Hidetoshi Yanagi, Harumi Konishi, Masanobu Yanase, Norihide Fukushima
PURPOSE: Although cardiac rehabilitation is recommended for patients early after heart transplantation (HTx), adequate exercise effect cannot always be obtained, partly because in patients with chronic heart failure, exercise capacity is reduced due to malnutrition during waiting for HTx. This study aimed to investigate the relationships between exercise capacity and clinical variables, including nutritional indicators, early after HTx. PATIENTS AND METHODS: Forty three HTx recipients were studied...
December 1, 2017: Clinical Transplantation
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