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https://www.readbyqxmd.com/read/28728213/performance-of-non-invasive-prenatal-screening-for-fetal-aneuploidy-in-twin-pregnancies-a-meta-analysis
#1
Hong Liao, Shanling Liu, He Wang
OBJECTIVE: The objective of this study was to review the published studies of non-invasive prenatal screening (NIPS) in twin pregnancies and to evaluate the performance for screening fetal trisomies 21, 18, and 13 in twin pregnancies. METHOD: Ten eligible studies were included in this meta-analysis. Data analysis, heterogeneity exploring, meta-regression and subgroup analysis were all conducted with Meta-DiSc 1.4. Quality assessments were carried out with the Quality Assessment Tool for Diagnostic Accuracy Studies (QUADAS-2)...
July 20, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28724122/association-between-patient-age-and-lymph-node-positivity-in-thin-melanoma
#2
Andrew J Sinnamon, Madalyn G Neuwirth, Pratyusha Yalamanchi, Phyllis Gimotty, David E Elder, Xiaowei Xu, Rachel R Kelz, Robert E Roses, Emily Y Chu, Michael E Ming, Douglas L Fraker, Giorgos C Karakousis
Importance: More than half of all new melanoma diagnoses present as clinically localized T1 melanoma, yet sentinel lymph node biopsy (SLNB) is controversial in this population given the overall low yield. Guidelines for SLNB have focused on pathologic factors, but patient factors, such as age, are not routinely considered. Objectives: To identify indicators of lymph node (LN) metastasis in thin melanoma in a large, generalizable data set and to evaluate the association between patient age and LN positivity...
July 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28717870/laparoscopic-liver-resections-for-hepatocellular-carcinoma-can-we-extend-the-surgical-indication-in-cirrhotic-patients
#3
Federica Cipriani, Corrado Fantini, Francesca Ratti, Roberto Lauro, Hadrien Tranchart, Mark Halls, Vincenzo Scuderi, Leonid Barkhatov, Bjorn Edwin, Roberto I Troisi, Ibrahim Dagher, Paolo Reggiani, Giulio Belli, Luca Aldrighetti, Mohammad Abu Hilal
BACKGROUND: Evidence on the value of laparoscopic liver resections (LLR) for hepatocellular carcinoma (HCC) and severe cirrhosis is still lacking. The aim of this study is to assess surgical and oncological outcomes of LLR in cirrhotic HCC patients. METHODS: The analysis included 403 LLR for HCC from seven European centres. 333 cirrhotic and 70 non-cirrhotic patients were compared. A matched comparison was performed between 100 Child-Pugh A and 25 Child-Pugh B patients...
July 17, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28717714/phenotype-and-treatment-of-breast-cancer-in-hiv-positive-and-negative-women-in-cape-town-south-africa
#4
Lizanne Langenhoven, Pieter Barnardt, Alfred I Neugut, Judith S Jacobson
PURPOSE: An estimated 5.9 million people in South Africa are infected with HIV. Because antiretroviral therapy has made infection with HIV a treatable, chronic condition, HIV-infected individuals are now surviving to middle and older age. We investigated the implications of HIV status for breast cancer in South Africa. METHODS: We compared clinical and demographic characteristics of women newly diagnosed with a first primary breast cancer at Tygerberg Hospital, Cape Town, South Africa, from January 2010 to December 2011 by HIV status...
October 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28715131/transcriptome-analysis-suggests-a-role-for-the-differential-expression-of-cerebral-aquaporins-and-the-mapk-signalling-pathway-in-human-temporal-lobe-epilepsy
#5
Mootaz M Salman, Mariam A Sheilabi, Dev Bhattacharyya, Philip Kitchen, Alex C Conner, Roslyn M Bill, M Nicola Woodroofe, Matthew T Conner, Alessandra P Princivalle
Epilepsies are common disorders of the central nervous system (CNS), affecting up to 2% of the global population. Pharmaco-resistance is a major clinical challenge affecting about 30% of temporal lobe epilepsy (TLE) patients. Water homeostasis has been shown crucial for regulation of neuronal excitability. The control of water movement is achieved through a family of small integral membrane channel proteins called aquaporins (AQPs). Despite the fact that changes in water homeostasis occur in sclerotic hippocampi of people with TLE, the expression of AQPs in the epileptic brain is not fully characterised...
July 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28713368/the-sptransformer-gene-family-formerly-sp185-333-in-the-purple-sea-urchin-and-the-functional-diversity-of-the-anti-pathogen-rsptransformer-e1-protein
#6
REVIEW
L Courtney Smith, Cheng Man Lun
The complex innate immune system of sea urchins is underpinned by several multigene families including the SpTransformer family (SpTrf; formerly Sp185/333) with estimates of ~50 members, although the family size is likely variable among individuals of Strongylocentrotus purpuratus. The genes are small with similar structure, are tightly clustered, and have several types of repeats in the second of two exons and that surround each gene. The density of repeats suggests that the genes are positioned within regions of genomic instability, which may be required to drive sequence diversification...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28712074/efficacy-and-safety-of-shp465-mixed-amphetamine-salts-in-the-treatment-of-attention-deficit-hyperactivity-disorder-in-adults-results-of-a-randomized-double-blind-placebo-controlled-forced-dose-clinical-study
#7
Richard H Weisler, Michael Greenbaum, Valerie Arnold, Ming Yu, Brian Yan, Margo Jaffee, Brigitte Robertson
OBJECTIVE: The objective of this randomized, double-blind, placebo-controlled study was to evaluate the efficacy and safety of SHP465 mixed amphetamine salts (MAS) in adults with attention-deficit/hyperactivity disorder (ADHD). METHODS: Eligible adults [aged 18-55 years; meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition ADHD criteria; baseline ADHD Rating Scale with Adult Prompts (ADHD-RS-AP) total scores ≥28] were randomized 1:1:1 to placebo or forced-dose SHP465 MAS (12...
July 15, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28711732/high-level-expression-and-purification-of-a-mollusca-endoglucanase-from-ampullaria-crossean-in-pichia-pastoris
#8
Xiuping Su, Xinwei Geng, Meixian Fu, Yeqing Wu, Longfei Yin, Fukun Zhao, Wei Chen
EG27I is an endogenous glucanase belonging to glycoside hydrolase family (GHF) 45 from the Mollusca, Ampullaria crossean. In this study, the EG27I mature peptide gene fused to HFBII secretion signal of Trichoderma reesei was expressed under GAP promoter of Pichia pastoris in SMD1163 strain. Bioactive EG27I with a molecular weight of 27 kDa was successfully expressed and secreted into the culture medium. When high cell density fermentation of the recombinant Pichia pastoris was performed by a fed-batch strategy for totally 132 h in a 7...
July 12, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28708499/split-time-artificial-insemination-in-beef-cattle-iii-comparing-fixed-time-artificial-insemination-to-split-time-artificial-insemination-with-delayed-administration-of-gnrh-in-postpartum-cows
#9
B E Bishop, J M Thomas, J M Abel, S E Poock, M R Ellersieck, M F Smith, D J Patterson
This experiment was designed to compare pregnancy rates in postpartum beef cows following split-time (STAI) or fixed-time (FTAI) artificial insemination. Estrus was synchronized for 671 cows at seven locations following administration of the 7-d CO-Synch + CIDR protocol (100 μg GnRH + CIDR insert [1.38 g progesterone] on d 0; 25 mg prostaglandin F2α [PG] at CIDR removal on d 7). Cows were assigned to treatments that were balanced across locations based on age, body condition score, and days postpartum at the time treatments were initiated...
April 29, 2017: Theriogenology
https://www.readbyqxmd.com/read/28705189/a-biomechanical-comparison-of-conventional-dynamic-compression-plates-and-string-of-pearls%C3%A2-locking-plates-using-cantilever-bending-in-a-canine-ilial-fracture-model
#10
Allison R Kenzig, James R Butler, Lauren B Priddy, Kristen R Lacy, Steven H Elder
BACKGROUND: Fracture of the ilium is common orthopedic injury that often requires surgical stabilization in canine patients. Of the various methods of surgical stabilization available, application of a lateral bone plate to the ilium is the most common method of fixation. Many plating options are available, each having its own advantages and disadvantages. The purpose of this study was to evaluate the biomechanical properties of a 3.5 mm String-of-Pearls™ plate and a 3.5 mm dynamic compression plate in a cadaveric canine ilial fracture model...
July 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28704348/quickstats-age-adjusted-alzheimer-s-disease-death-rates-%C3%A2-among-persons-aged-%C3%A2-65-years-by-state-%C3%A2-united-states-2015
#11
(no author information available yet)
In 2015, the age-adjusted Alzheimer's disease death rate among persons aged ≥65 years in the United States was 231.0 per 100,000 population. The five states with the highest age-adjusted death rates for Alzheimer's disease were South Carolina (362.8), Washington (349.6), Mississippi (346.5), Tennessee (340.8), and Louisiana (333.6). New York had the lowest rate (99.0), followed by Maryland (128.2), Alaska (131.7), Connecticut (149.3), and the District of Columbia (152.2).
July 14, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28704108/reliability-of-kinetic-visual-field-testing-in-children-with-mutation-proven-retinal-dystrophies-implications-for-therapeutic-clinical-trials
#12
Vaidehi S Dedania, Jerry Y Liu, Dana Schlegel, Chris A Andrews, Kari Branham, Naheed W Khan, David C Musch, John R Heckenlively, K Thiran Jayasundera
PURPOSE: Kinetic visual field testing is used to monitor disease course in retinal dystrophy clinical care and treatment response in treatment trials, which are increasingly recruiting children. This study investigates Goldmann visual field (GVF) changes in young children with mutation-proven retinal dystrophies as they age and with progression of the retinal degeneration. METHODS: Retrospective review of children ≤ 17 years old with a mutation-proven retinal dystrophy...
July 13, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28700356/a-novel-anionic-phosphate-platinum-complex-effectively-targets-an-undifferentiated-pleomorphic-sarcoma-better-than-cisplatinum-and-doxorubicin-in-a-patient-derived-orthotopic-xenograft-pdox
#13
Kentaro Igarashi, Kei Kawaguchi, Takashi Murakami, Tasuku Kiyuna, Kentaro Miyake, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Scott D Nelson, Sarah M Dry, Yunfeng Li, Arun S Singh, Shinji Miwa, Akira Odani, Fritz C Eilber, Hiroyuki Tsuchiya, Robert M Hoffman
A patient high-grade undifferentiated pleomorphic soft-tissue sarcoma (UPS) from a striated muscle was previously orthotopically implanted in the right biceps femoris muscle of nude mice to establish a patient-derived orthotopic xenograft (PDOX) nude-mouse model. In the present study, two weeks after orthotopic transplantation of the UPS, mice were treated intraperitoneally with cisplatinum (CDDP), doxorubicin (DOX) or a novel anionic-phosphate-platinum compound 3Pt. Treatments were repeated weekly for a total of 3 times...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28700336/gene-expression-profiling-to-predict-recurrence-of-advanced-squamous-cell-carcinoma-of-the-tongue-discovery-and-external-validation
#14
Tomohiro Enokida, Satoshi Fujii, Mari Takahashi, Youichi Higuchi, Shogo Nomura, Tetsuro Wakasugi, Tomoko Yamazaki, Ryuichi Hayashi, Atsushi Ohtsu, Makoto Tahara
OBJECTIVES: To establish a prognostic signature for locally advanced tongue squamous cell carcinoma (TSCC) patients treated with surgery. RESULTS: In the discovery study, unsupervised hierarchical clustering analysis identified two clusters which differentiated the Kaplan-Meier curves of RFS [median RFS, 111 days vs. not reached; log-rank test, P = 0.023]. The 30 genes identified were combined into a dichotomous PI. In the validation cohort, classification according to the PI was associated with RFS [median RFS, 754 days vs...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28700141/zero-and-second-derivative-synchronous-fluorescence-spectroscopy-for-the-quantification-of-two-non-classical-%C3%AE-lactams-in-pharmaceutical-vials-application-to-stability-studies
#15
Eman S Elzanfaly, Rania M Youssif, Nahla N Salama, Ahmed S Fayed, Hassan A M Hendawy, Maissa Y Salem
The formation of metal chelates with various ligands may lead to the production of fluorescent chelates or enhance the fluorescence of the chelating agent. This paper describes two sensitive, selective and computer-solved methods, namely, zero order (SF) and second-derivative synchronous spectrofluorimetry (SDSFS) for nano-quantitation of two carbapenems; meropenem (MP) and ertapenem (EP). The methods are based on the chelation of MP with Tb(3+) and EP with Zr(4+) in buffered organic medium at pH 4.0 to produce fluorescent chelates...
July 12, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28699741/iron-ii-complexes-of-2-4-dipyrazolyl-1-3-5-triazine-derivatives-the-influence-of-ligand-geometry-on-metal-ion-spin-state
#16
Izar Capel Berdiell, Rafal Kulmaczewski, Malcolm A Halcrow
Seven [FeL2][BF4]2 complex salts were prepared, where L is a 6-substituted 2,4-di(pyrazol-1-yl)-1,3,5-triazine (bpt) derivative. The complexes are all crystallographically high-spin, and exhibit significant distortions from an ideal D2d-symmetric coordination geometry. In one case, an unusual type of metal ion disorder was observed among a cubic array of ligands in the crystal lattice. The complexes are also high-spin between 3 and 300 K in the solid state and, where measured, between 239 and 333 K in CD3CN solution...
July 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28697871/patterns-of-antimicrobial-agent-prescription-in-a-sentinel-population-of-canine-and-feline-veterinary-practices-in-the-united-kingdom
#17
D A Singleton, F Sánchez-Vizcaíno, S Dawson, P H Jones, P J M Noble, G L Pinchbeck, N J Williams, A D Radford
Antimicrobial resistance is an increasingly important global health threat and the use of antimicrobial agents is a key risk factor in its development. This study describes antimicrobial agent prescription (AAP) patterns over a 2year period using electronic health records (EHRs) from booked consultations in a network of 457 sentinel veterinary premises in the United Kingdom. A semi-automated classification methodology was used to map practitioner defined product codes in 918,333 EHRs from 413,870 dogs and 352,730 EHRs from 200,541 cats, including 289,789 AAPs...
June 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28697380/assessment-of-carbon-sequestration-potential-of-revegetated-coal-mine-overburden-dumps-a-chronosequence-study-from-dry-tropical-climate
#18
Jitendra Ahirwal, Subodh Kumar Maiti
Development of secondary forest as post-mining land use in the surface coal mining degraded sites is of high research interest due to its potential to sequester atmospheric carbon (C). The objectives of this study were to assess the improvement in mine soil quality and C sequestration potential of the post-mining reclaimed land with time. Hence, this study was conducted in reclaimed chronosequence sites (young, intermediate and old) of a large open cast coal project (Central Coal Fields Limited, Jharkhand, India) and results were compared to a reference forest site (Sal forest, Shorea robusta)...
July 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28697066/viral-induced-modulation-of-multiple-checkpoint-proteins-in-cancers
#19
Gerard J Nuovo, Virginia A Folcik, Cynthia Magro
Therapy with checkpoint inhibitors represents a major advance in cancer treatment. The purpose of this study was to examine the expression patterns of the checkpoint proteins programmed death ligand 1 (PD L1), PD L2, indoleamine 2,3-dioxygenase 1 (IDO1), and cytotoxic T-lymphocyte antigen 4 (CTLA4) in cancers including those associated with viral infections. Normal, noninflamed tissues rarely express checkpoint proteins with exceptions including the placenta and stomach. Expression of PD L1 was noted in 30%, PD L2 in 18%, IDO1 in 13%, and CTLA4 in 14% of 333 nonviral malignancies including endometrial, ovarian, lung, and breast cancers...
July 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28697025/reboa-for-the-ivc-resuscitative-balloon-occlusion-of-the-inferior-vena-cava-rebovc-to-abate-massive-hemorrhage-in-retro-hepatic-vena-cava-injuries
#20
Cassandra L Reynolds, Adam C Celio, Lindsay C Bridges, Catalina Mosquera, Brian O'Connell, Michael R Bard, Connie M DeLa'o, Eric A Toschlog
BACKGROUND: The use of resuscitative endovascular balloon occlusion as a maneuver for occlusion of the aorta is well described. This technique has life-saving potential in other cases of traumatic hemorrhage. Retro-hepatic inferior vena cava (IVC) injuries have a high rate of mortality, in part, due to the difficulty in achieving total vascular isolation. This studies purpose was to investigate the ability of resuscitative balloon occlusion of the IVC (REBOVC) to control supra-hepatic IVC hemorrhage in a swine model of trauma...
July 8, 2017: Journal of Trauma and Acute Care Surgery
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