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https://www.readbyqxmd.com/read/29244774/3dcons-db-a-database-of-position-specific-scoring-matrices-in-protein-structures
#1
Ruben Sanchez-Garcia, Carlos Oscar Sanchez Sorzano, Jose Maria Carazo, Joan Segura
Many studies have used position-specific scoring matrices (PSSM) profiles to characterize residues in protein structures and to predict a broad range of protein features. Moreover, PSSM profiles of Protein Data Bank (PDB) entries have been recalculated in many works for different purposes. Although the computational cost of calculating a single PSSM profile is affordable, many statistical studies or machine learning-based methods used thousands of profiles to achieve their goals, thereby leading to a substantial increase of the computational cost...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29244080/quantification-of-methadone-and-main-metabolites-in-nails
#2
Teresa Patrícia Magalhães, Sara Cravo, Diana Dias da Silva, Ricardo Jorge Dinis-Oliveira, Carlos Afonso, Maria de Lourdes Bastos, Helena Carmo
The quantification of drugs of abuse in keratinized matrices is becoming of special relevance for monitoring consumption and for post-mortem investigations. We aimed to implement an analytical method for the simultaneous detection of morphine (MORF), 6-monoacetylmorphine (6-MAM), methadone (MET), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyrrolidine (EMDP) in nails. After decontamination, the nail samples (30 mg) were submitted to an alkaline digestion followed by a two-step liquid-liquid and SPE extraction using mixed-mode cation exchange cartridges...
December 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29243435/-new-qualities-control-strategy-of-scutellaria-baicalensis-by-isothermal-titration-calorimetry
#3
Tong Li, Hao Zhang, Xue-Hao Tian, Hui Wang, Guang-Xi Ren, Wen-Guang Jing, Bing Xu, Fu-Hao Chu, Peng-Long Wang, Hai-Min Lei
It has been focused on that there will be precipitates when decoction of Scutellariat Radix mixed with Coptidis Rhizoma. Precipitation was derived from interaction between acidic and basic compounds. This study was based on the interaction between active ingredients after compatibility, strived to explore whether it was feasible to judge the qualities of different Scutellariat Radix by isothermal titration calorimetry (ITC), build a new method established to characterize the qualities of traditional Chinese medicine by taking a series of active ingredients as index...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29241692/in%C3%A2-vitro-inhibitory-effects-of-major-bioactive-constituents-of-andrographis-paniculata-curcuma-longa-and-silybum-marianum-on-human-liver-microsomal-morphine-glucuronidation-a-prediction-of%C3%A2-potential-herb-drug-interactions-arising-from-andrographolide-curcumin
#4
Verawan Uchaipichat
This study aimed to investigate the liver microsomal inhibitory effects of silybin, silychristin, andrographolide, and curcumin by using morphine as an in vitro UGT2B7 probe substrate, and predict the magnitude of the herb-drug interaction arising from these herbal constituents' inhibition in vivo. Studies were performed in the incubation with and without bovine serum albumin (BSA). Andrographolide and curcumin showed a marked inhibition on morphine 3- and 6-glucuronidation with IC50 of 50&87 and 96&111 μM, respectively...
November 20, 2017: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29240803/bone-edema-on-magnetic-resonance-imaging-is-highly-associated-with-low-bone-mineral-density-in-patients-with-ankylosing-spondylitis
#5
Danmin Wang, Zhiduo Hou, Yao Gong, Subiao Chen, Ling Lin, Zhengyu Xiao
OBJECTIVE: This study aimed to assess the relationship between bone marrow edema (BME) on magnetic resonance imaging (MRI) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). METHODS: The study included 333 patients with AS who underwent BMD measurements and axial MRI. Additionally, 106 normal controls were included. The modified New York criteria were used as the classification criteria of AS. Clinical, laboratory, and imaging data were collected and analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/29239014/cortical-electrical-stimulation-in-female-rats-with-a-cervical-spinal-cord-injury-to-promote-axonal-outgrowth
#6
Andrew S Jack, Caitlin Hurd, Juan Forero, Andrew Nataraj, Keith Fenrich, Armin Blesch, Karim Fouad
Electrical stimulation (ES) to promote corticospinal tract (CST) repair after spinal cord injury (SCI) is underinvestigated. This study is the first to detail intracortical ES of the injured CST. We hypothesize that cortical ES will promote CST collateralization and regeneration, prevent dieback, and improve recovery in an SCI rat model. The CST was transected at the the fourth cervical level in adult female Lewis rats trained in a stairwell grasping task. Animal groups included (a) ES333 (n = 14; 333 Hz, biphasic pulse for 0...
December 14, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29235388/early-outcomes-of-the-t-branch-off-the-shelf-multibranched-stent-graft-in-urgent-thoracoabdominal-aortic-aneurysm-repair
#7
Konstantinos Spanos, Tilo Kölbel, Myrto Theodorakopoulou, Franziska Heidemann, Fiona Rohlffs, Eike Sebastian Debus, Nikolaos Tsilimparis
PURPOSE: To assess the short-term outcomes of the multibranched off-the-shelf t-Branch stent-graft for urgent thoracoabdominal aortic aneurysm (TAAA) repair and to evaluate the impact on outcomes of the learning curve and adherence to the instruction for use (IFU). METHODS: Between 2014 and 2017, 42 patients (mean age 73.3±7 years; 26 men) underwent urgent TAAA treatment using the t-Branch stent-graft [18 in the early (2014-2015) period and 24 in the late (2016-2017) period]...
December 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29232841/two-channel-spr-sensor-combined-application-of-polymer-and-vitreous-clad-optic-fibers
#8
Yong Wei, Yudong Su, Chunlan Liu, Xiangfei Nie, Zhihai Liu, Yu Zhang, Yonghui Zhang
By combining a polymer-clad optic fiber and a vitreous-clad optic fiber, we proposed and fabricated a novel optic fiber surface plasmon resonance (SPR) sensor to conduct two-channel sensing at the same detection area. The traditional optic fiber SPR sensor has many disadvantages; for example, removing the cladding requires corrosion, operating it is dangerous, adjusting the dynamic response range is hard, and producing different resonance wavelengths in the sensing area to realize a multi-channel measurement is difficult...
December 9, 2017: Sensors
https://www.readbyqxmd.com/read/29231356/-acupuncture-for-diarrhea-predominant-irritable-bowel-syndrome-a-meta-analysis
#9
REVIEW
Duoxi Deng, Kuikui Guo, Jie Tan, Guilan Huang, Shuai Li, Quanrui Jiang, Jiao Xie, Hui Xie, Zhiqi Zhang, Ying Chen, Liang Peng
OBJECTIVE: To systematically evaluate the efficacy and safety of acupuncture on diarrhea-predominant irritable bowel syndrome (IBS) in the past five years. METHODS: Online databases, including CNKI, VIP, WANFANG, PubMed, CBM, ScienceDirect OnSite, Cochrane Library, etc. were searched for randomized controlled trials (RCTs) of acupuncture for diarrhea-predominant IBS. Retrieval time was from January of 2011 to January of 2016. According to modified Jadad standard, the bias risk and quality assessment of each RCT included were evaluated by two researchers...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230867/sleep-patterns-and-problems-in-infants-and-young-children-in-ireland
#10
S Hanafin
BACKGROUND: There is an increasing recognition that sleep is an important aspect of health and well-being, and this is particularly the case in infancy and early childhood where sleep behaviours and patterns can result in substantial problems. METHODS: This paper draws on Wave 1, 2, and 3 data from Growing Up in Ireland, the national longitudinal study of children in Ireland to provide an overview of sleep patterns in a population of children aged 9 months (n = 11,112), 3 years (n = 9,790), and 5 years (n = 8,996)...
December 12, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29226821/patterns-of-civilian-and-child-deaths-due-to-war-related-violence-in-syria-a-comparative-analysis-from-the-violation-documentation-center-dataset-2011-16
#11
Debarati Guha-Sapir, Benjamin Schlüter, Jose Manuel Rodriguez-Llanes, Louis Lillywhite, Madelyn Hsiao-Rei Hicks
BACKGROUND: Since March, 2011, the Syrian civil war has lowered life expectancy by as much as 20 years. We describe demographic, spatial, and temporal patterns of direct deaths of civilians and opposition combatants from conflict-related violence in 6 years of war. METHODS: We analysed conflict-related violent deaths with complete information on date, place, and cause of death and demographic group occurring from March 18, 2011, to Dec 31, 2016, recorded by the Violation Documentation Center (VDC)...
November 29, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29223668/transumbilical-extracorporeal-laparoscopic-assisted-appendectomy
#12
Lindsey Perea, William H Peranteau, Pablo Laje
AIM OF THE STUDY: The perfect balance between safety, cosmesis, and cost effectiveness in a world with ever growing healthcare costs has yet to be found for nonperforated appendicitis. The aim is to present our data regarding safety and cost effectiveness of the transumbilical extracorporeal laparoscopic-assisted appendectomy technique. METHODS: A retrospective review was performed for all laparoscopic appendectomies for acute appendicitis from October 2014 to October 2016...
November 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29223321/is-there-value-in-retrospective-90-day-bundle-payment-models-for-shoulder-arthroplasty-procedures
#13
Susan M Odum, Nady Hamid, Bryce A Van Doren, Leo R Spector
BACKGROUND: The Centers for Medicare & Medicaid Services Bundled Payments for Care Improvement (BPCI) initiative was implemented as part of the Affordable Care Act. We implemented a retrospective payment model 2 for a 90-day total shoulder arthroplasty (TSA) episode to assess the value of TSA BPCI at our private practice. METHODS: Expenditures and postacute event rates of 132 fee-for-service (FFS) patients who underwent a TSA operation between 2009 and 2012 were compared with 333 BPCI patients who had a TSA operation in 2015...
December 7, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29218712/disposable-skin-staplers-for-closure-of-linear-gastrointestinal-incisions-in-dogs
#14
Zeev Schwartz, Bradley R Coolman
OBJECTIVE: To report the clinical features and outcomes of linear gastrointestinal incisions closed with skin staples in dogs. STUDY DESIGN: Historical cohort study. ANIMALS: 333 client-owned dogs. METHODS: Medical records from 1 private referral hospital were searched for dogs that underwent gastrointestinal surgery between November 1999 and October 2015. Cases were included if skin staplers were used to close linear gastrointestinal incisions...
December 8, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29218443/prevalence-and-associated-risk-factors-of-giardia-duodenalis-infection-among-school-going-children-in-nepal
#15
Sarmila Tandukar, Jeevan B Sherchand, Jia Xue, Sital Uprety, Samendra P Sherchan, Dinesh Bhandari, Bikash Malla, Rajani Ghaju Shrestha, Laxmi Parajuli, Shristi Poudel, Ashmita Dhital, Eiji Haramoto
This study aimed to determine the prevalence of intestinal parasites and its associated risk factors among school-going children in Kathmandu, Nepal. Between August and September 2016, a total of 333 stool samples were collected from children at five public schools. The collected samples were subjected to formol-ether concentration, followed by conventional microscopic examination for intestinal parasites. The overall prevalence of intestinal parasites was 24.3% (81/333), with Giardia spp. showing the highest prevalence of 18...
December 7, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29217936/utilization-of-primary-health-care-services-in-jaba-local-government-area-of-kaduna-state-nigeria
#16
Agofure Otovwe, Sarki Elizabeth
Background: Primary health care was designed to provide accessible health care for all. However, most primary health care facilities are in various states of disrepair, catering for less than 20% of potential patients in the population. This study was designed to investigate the utilisation of primary health care services in Jaba Local Government Area of Kaduna State Nigeria. Methods: The study employed a cross-sectional study design conducted among 383 respondents utilising simple random sampling techniques...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29215477/prophylactic-ureteral-catheters-for-colectomy-a-national-surgical-quality-improvement-program-based-analysis
#17
Kathleen M Coakley, Kevin R Kasten, Stephanie M Sims, Tanushree Prasad, B Todd Heniford, Bradley R Davis
BACKGROUND: Despite improvement in technique and technology, using prophylactic ureteral catheters to avoid iatrogenic ureteral injury during colectomy remains controversial. OBJECTIVE: The aim of this study was to evaluate outcomes and costs attributable to prophylactic ureteral catheters with colectomy. DESIGN: This was a retrospective study. SETTINGS: The study was conducted at a single tertiary care center. PATIENTS: The colectomy-targeted American College of Surgeons National Surgical Quality Improvement Program database from 2012 to 2014 was queried...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29214386/improvement-rate-of-patients-with-severe-brain-injury-during-post-acute-intensive-rehabilitation
#18
Rita Formisano, Marianna Contrada, Marta Aloisi, Maria Gabriella Buzzi, Paola Cicinelli, Cecilia Della Vedova, Letizia Laurenza, Maria Matteis, Francesca Spanedda, Vincenzo Vinicola, Marco Iosa
Patients with severe acquired brain injury (SABI) may evolve towards different outcomes. The primary aim was to evaluate the clinical evolution of a large population of patients with SABI admitted to post-acute rehabilitation from 2001 to 2016, diagnosed with severe brain injury (GCS ≤ 8) in the acute phase and a coma duration of at least 24 h. The possible changes between the admission time to a post-acute rehabilitation hospital and the discharge time were measured by means of Glasgow Outcome Scale (GOS), Level of Cognitive Functioning (LCF), and Disability Rating Scale (DRS)...
December 6, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29211071/molecular-dynamics-simulation-of-geminal-dicationic-ionic-liquids-cn-mim-2-ntf2-2-structural-and-dynamical-properties
#19
Majid Moosavi, Fatemeh Khashei, Elaheh Sedghamiz
In this work, the structural and dynamical properties of two imidazolium-based geminal dicationic ionic liquids (GDILs), i.e. [Cn(mim)2][NTf2]2 with n = 3 and 5, have been studied to obtain a fundamental understanding of the molecular basis of the macroscopic and microscopic properties of the bulk liquid phase. To achieve this purpose, molecular dynamics (MD) simulation, density functional theory (DFT) and atoms in molecule (AIM) methods were used. Interaction energies, charge transfers and hydrogen bonds between the cation and anions of each studied GDIL were investigated by DFT calculations and also AIM...
December 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29211053/impacts-of-small-scale-industrialized-swine-farming-on-local-soil-water-and-crop-qualities-in-a-hilly-red-soil-region-of-subtropical-china
#20
Di Zhang, Xingxiang Wang, Zhigao Zhou
Industrialized small-scale pig farming has been rapidly developed in developing regions such as China and Southeast Asia, but the environmental problems accompanying pig farming have not been fully recognized. This study investigated 168 small-scale pig farms and 29 example pig farms in Yujiang County of China to examine current and potential impacts of pig wastes on soil, water and crop qualities in the hilly red soil region, China. The results indicated that the small-scale pig farms produced considerable annual yields of wastes, with medians of 216, 333 and 773 ton yr-1 per pig farm for manure, urine and washing wastewater, respectively, which has had significant impact on surface water quality...
December 6, 2017: International Journal of Environmental Research and Public Health
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