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https://www.readbyqxmd.com/read/29029193/sex-and-iron-modify-fibroblast-growth-factor-23-fgf23-concentration-in-1-year-old-children
#1
Elisa Holmlund-Suila, Maria Enlund-Cerullo, Saara Valkama, Helena Hauta-Alus, Jenni Rosendahl, Otto Helve, Timo Hytinantti, Heli Viljakainen, Sture Andersson, Outi Mäkitie
Context: Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis but its regulation is inadequately characterized. Objective: To examine regulators of FGF23, especially sex and iron status, in early childhood. Design: A cross-sectional study involving 1-year-old children. Setting and participants: Healthy term infants with a birth weight appropriate for gestational age were recruited to an ongoing vitamin D trial at the Kätilöopisto Maternity Hospital, Helsinki, Finland...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028822/serial-omics-characterization-of-equine-urine
#2
Min Yuan, Susanne B Breitkopf, John M Asara
Horse urine is easily collected and contains molecules readily measurable using mass spectrometry that can be used as biomarkers representative of health, disease or drug tampering. This study aimed at analyzing microliter levels of horse urine to purify, identify and quantify proteins, polar metabolites and non-polar lipids. Urine from a healthy 12 year old quarter horse mare on a diet of grass hay and vitamin/mineral supplements with limited pasture access was collected for serial-omics characterization. The urine was treated with methyl tert-butyl ether (MTBE) and methanol to partition into three distinct layers for protein, non-polar lipid and polar metabolite content from a single liquid-liquid extraction and was repeated two times...
2017: PloS One
https://www.readbyqxmd.com/read/29028491/boron-removal-from-hydraulic-fracturing-wastewater-by-aluminum-and-iron-coagulation-mechanisms-and-limitations
#3
Darpan Chorghe, Mutiara Ayu Sari, Shankararaman Chellam
One promising water management strategy during hydraulic fracturing is treatment and reuse of flowback/produced water. In particular, the saline flowback water contains many of the chemicals employed for fracking, which need to be removed before possible reuse as "frac water." This manuscript targets turbidity along with one of the additives; borate-based cross-linkers used to adjust the rheological characteristics of the frac-fluid. Alum and ferric chloride were evaluated as coagulants for clarification and boron removal from saline flowback water obtained from a well in the Eagle Ford shale...
September 28, 2017: Water Research
https://www.readbyqxmd.com/read/29027956/combined-venom-gland-transcriptomic-and-venom-peptidomic-analysis-of-the-predatory-ant-odontomachus-monticola
#4
Kohei Kazuma, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki
Ants (hymenoptera: Formicidae) have adapted to many different environments and have become some of the most prolific and successful insects. To date, 13,258 ant species have been reported. They have been classified into 333 genera and 17 subfamilies. Except for a few Formicinae, Dolichoderinae, and members of other subfamilies, most ant species have a sting with venom. The venoms are composed of formic acid, alkaloids, hydrocarbons, amines, peptides, and proteins. Unlike the venoms of other animals such as snakes and spiders, ant venoms have seldom been analyzed comprehensively, and their compositions are not yet completely known...
October 13, 2017: Toxins
https://www.readbyqxmd.com/read/29026273/detection-of-early-stage-medullary-thyroid-carcinoma-by-measuring-serum-calcitonin-using-an-electro-chemiluminescence-immuno-assay-a-case-report-of-a-young-japanese-woman-with-a-high-risk-ret-mutation
#5
Yuki Abe, Shinya Tsukano
Medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder caused by the mutation of the RET proto-oncogene, that shows nearly complete penetration. The American Thyroid Association guidelines recommend prophylactic thyroidectomy for patients with high-risk RET mutations. However, in Japan, ethical and medical issues may preclude prophylactic treatment in young patients. Hence, an early diagnosis of MTC is necessary to ensure a favorable outcome. Here, we report the case of a young Japanese girl with a high-risk RET mutation, diagnosed with very early stage MTC using serum calcitonin (Ctn) values measured using an electro chemiluminescence immuno-assay (ECLIA)...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29023858/interleukin-1-gene-cluster-haplotype-analysis-in-the-chronic-outcome-prediction-of-the-hepatitis-b-virus-infection
#6
Bita Javan, Mohamad Reza Kalani, Majid Shahbazi
Hepatitis B virus (HBV) infection is well known as an important cause of the chronic liver disease. The screening of the genotype of certain cytokines might be helpful to predict the clinical outcome of an HBV infection. The present study investigates the relationship between the polymorphism and haplotypes of the Interleukin-1 (IL-1) gene family, including IL-1-alpha (IL-1A), IL-1-beta (IL-1B) and IL-1 receptor antagonist (IL-1RN), with chronic HBV infection. 297 chronic HBV and 333 matched on sex and age control individuals were genotyped using the standard sequence-specific- polymerase chain reaction primer (SSP-PCR) method...
October 11, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29022358/development-of-the-injury-perceptions-questionnaire-injpq
#7
Irit Heruti, Sigal Levy, Ronit Avitsur, Daniel Deutscher, Moshe Gutvirtz, Tamar Berkovitz, Shoshana Shiloh
OBJECTIVES: Injuries are major causes of morbidity and mortality in the population. Given the central role of perceptions in self-regulation of health conditions, it is important to investigate how they are perceived. This article describes the development of the Injury Perceptions Questionnaire (InjPQ). METHODS: A concurrent study in a diverse sample of injured individuals (n = 333). The internal structure and the reliability (Cronbach's α) of InjPQ sub-scales were explored by factor analyses...
October 12, 2017: Psychology & Health
https://www.readbyqxmd.com/read/29021115/specialty-addiction-and-psychiatry-treatment-initiation-and-engagement-results-from-an-sbirt-randomized-trial-in-pediatrics
#8
Stacy Sterling, Andrea H Kline-Simon, Ashley Jones, Derek D Satre, Sujaya Parthasarathy, Constance Weisner
OBJECTIVE: Many adolescents needing specialty addiction or psychiatry treatment never access care. We examined initiation and engagement with addiction and/or psychiatry treatment among adolescents referred to treatment from a trial comparing two different modalities of delivering Screening, Brief Intervention and Referral to Treatment (SBIRT) to Usual Care in pediatric primary care. We hypothesized that both intervention arms would have higher initiation and engagement rates than usual care...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29020425/changes-in-subfoveal-choroidal-thickness-during-pregnancy-and-after-delivery
#9
Junichi Takahashi, Masanori Kado, Keiko Mizumoto, Sho Igarashi, Tsunemaro Kojo
BACKGROUND AND OBJECTIVE: This study was performed to investigate longitudinal changes in the subfoveal choroidal thickness (SFCT) during pregnancy and after delivery. PATIENTS AND METHODS: The SFCT was measured in the first and third trimesters, shortly after delivery, and 1 month after delivery in 25 eyes of 25 women. Enhanced depth imaging optical coherence tomography was used for measurement. RESULTS: The mean SFCT was 347 μm ± 86 μm, 329 μm ± 81 μm, 333 μm ± 81 μm, and 330 μm ± 87 μm in the first and third trimesters, shortly after delivery, and 1 month after delivery, respectively...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29017647/-early-evaluation-of-patients-with-amplitude-integrated-electroencephalogram-on-brain-function-prognosis-after-cardiopulmonary-cerebral-resuscitation
#10
Xin Dong, Huanzhang Shao, Yanan Yang, Lijie Qin, Zhisong Guo, Huifeng Zhang, Xueyan Zhang, Bingyu Qin
OBJECTIVE: To explore the characteristic of early evaluation of patients with amplitude-integrated electroencephalogram (aEEG) on brain function prognosis after cardiopulmonary cerebral resuscitation (CPCR). METHODS: A retrospective analysis of the clinical data of patients with adult CPCR in intensive care unit (ICU) of Henan Provincial People's Hospital from March 2016 to March 2017 was performed. The length of stay, recovery time, acute physiology and chronic health evaluation II (APACHE II) score, aEEG and Glasgow coma scale (GCS) within 72 hours were recorded...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29016459/choroidal-structural-changes-and-vascularity-index-in-stargardt-disease-on-swept-source-optical-coherence-tomography
#11
Dhanashree Ratra, Roy Tan, Durgasri Jaishankar, Neha Khandelwal, Arushi Gupta, Jay Chhablani, Rupesh Agrawal
PURPOSE: To evaluate structural changes in the choroid of patients with Stargardt disease using swept source optical coherence tomography scans. METHODS: A retrospective comparison cohort study was conducted on 39 patients with Stargardt disease, and on 25 age and gender matched-healthy controls. Subfoveal choroidal thickness (SFCT) was computed from the swept source optical coherence tomography machine, and the scans were binarized into luminal area and stromal areas, which were then used to derive choroidal vascularity index (CVI)...
October 6, 2017: Retina
https://www.readbyqxmd.com/read/28994888/treatment-of-inguinal-hernia-by-lichtenstein-technique-an-open-prospective-study
#12
Imen Samaali, Hachem Hakim Zenaidi, Wejih Dougaz, Mehdi Khalfallah, Hichem Jarraya, Ramzi Nouira, Ibtissem Bouasker, Chadli Dziri
BACKGROUND: Treatment of inguinal hernia is still a challenge for the surgeon. The multitude of surgical techniques attests of the difficulty of choosing the best procedure. In the surgical B department of the Charles Nicolle Hospital we have chosen the Lichtenstein technique since 2008. The aim of this study was to evaluate the immediate and long-term results of this technique and to identify the predictive factors of recurrence. METHODS: This open prospective study included all patients who underwent an elective inguinal hernia repair in the surgical B department of the Charles Nicolle Hospital between June 1st 2008 and December 31st 2009...
December 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28990345/is-adjustment-disorder-unidimensional-or-multidimensional-implications-for-icd-11
#13
Louisa Lorenz, Philip Hyland, Axel Perkonigg, Andreas Maercker
In preparation for ICD-11, the adjustment disorder (AjD) diagnosis has undergone considerable revisions; however, the latent structure of AjD remains uncertain. It is unclear whether AjD is best represented as a unidimensional or multidimensional construct. This study performed a comprehensive assessment of the latent structure of AjD symptomatology and assessed its concurrent and discriminant validity. Individuals who experienced involuntary job loss (N = 333) completed a self-report measure of AjD symptoms...
October 8, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28988069/2018-tallied-facial-soft-tissue-thicknesses-for-adults-and-sub-adults
#14
Carl N Stephan
The tallied facial soft tissue thicknesses (or T-Tables) represent grand means of published facial soft tissue thickness sample means. These sample means have been drawn from across the full-breadth of the facial soft tissue thickness (FSTT) literature, including forensic science, anthropology and odontology. The report of new summary statistics for >1290 new sub-adults and >2200 new adults since the last T-Table calculation, in 2008 for sub-adults and 2013 for adults respectively, makes their update timely...
September 29, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28987960/frequencies-of-gene-variant-ccr5-%C3%AE-32-in-87-countries-based-on-next-generation-sequencing-of-1-3-million-individuals-sampled-from-3-national-dkms-donor-centers
#15
Ute V Solloch, Kathrin Lang, Vinzenz Lange, Irina Böhme, Alexander H Schmidt, Jürgen Sauter
Homozygous carriers of CCR5-Δ32, a gene variant of CC-type chemokine receptor 5 (CCR5), are highly resistant to infections with human immunodeficiency virus type 1 (HIV-1) and therefore preferred stem cell donors for HIV-infected patients. We analyzed CCR5 typing data of 1,333,035 potential hematopoietic stem cell donors enlisted with three national DKMS donor centers. Allele and genotype frequencies were determined for 87 countries of origin as self-assessed by the donors. CCR5-Δ32 allele frequencies ranged from 16...
October 5, 2017: Human Immunology
https://www.readbyqxmd.com/read/28987855/comparison-of-quality-metrics-for-pediatric-shunt-surgery-and-proposal-of-the-negative-shunt-revision-rate
#16
Thomas Beez, Hans-Jakob Steiger
OBJECTIVE: Shunt surgery is common in pediatric neurosurgery and is associated with relevant complication rates. We sought to compare previously published metrics in a single data set and propose the Negative Shunt Revision Rate (NSRR) as a new quality metric, defined as the proportion of shunt explorations revealing a properly working system. METHODS: A retrospective analysis of our shunt surgery activity in 2015 was performed. Demographic, clinical and radiological variables were extracted from electronic medical notes...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28987332/disparities-in-cancer-screening-by-occupational-characteristics
#17
Stacey A Fedewa, Ann Goding Sauer, Carol DeSantis, Rebecca L Siegel, Ahmedin Jemal
Cancer screening patterns according to occupation characteristics in the United States are not well known, but could be used to help inform cancer control efforts. We examined cervical (CC), breast (BC) and colorectal cancer (CRC) screening prevalence and prevalence ratios (PR) by occupational characteristics in 2010, 2013 and 2015 National Health Interview Surveys (NHIS) among eligible US workers (CC women 21-65years; n=20,997), (BC women ≥40years; n=14,258) and (CRC men and women ≥50years; n=17,333). Cervical, breast and colorectal cancer screening prevalence among US workers was 84...
October 5, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28987331/state-level-educational-disparities-in-mortality-in-the-united-states-2010-2014
#18
Jiemin Ma, Rebecca L Siegel, Elizabeth M Ward, Ahmedin Jemal
The present study examined educational disparities in mortality for 49 states and the District of Columbia in the United States based on the 2010-2014 national mortality data. A total of 3,165,762 deaths at ages 25-74years were included in analysis. Absolute and relative disparities were estimated as Relative Index of Inequality (RII) and Slope Index of Inequality (SII), respectively, based on age-standardized death rates by education, race/ethnicity sex, and state. We found that educational disparities in mortality existed in every US state with varying magnitude across states and by sex...
October 4, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28987132/improved-assessment-of-chest-pain-trial-impact-assessing-patients-with-possible-acute-coronary-syndromes
#19
Louise Cullen, Jaimi H Greenslade, Tracey Hawkins, Chris Hammett, Shanen O'Kane, Kimberley Ryan, Kate Parker, Jessica Schluter, Emily Dalton, Anthony Ft Brown, Martin Than, W Frank Peacock, Allan Jaffe, Peter K O'Rourke, William A Parsonage
OBJECTIVE: To examine the safety and efficacy of the Improved Assessment of Chest pain Trial (IMPACT) protocol, a strategy for accelerated assessment of patients presenting to emergency departments (EDs) with chest pain. DESIGN, SETTING AND PARTICIPANTS: IMPACT was an intervention trial at a single tertiary referral hospital (Royal Brisbane and Women's Hospital) during February 2011 - March 2014. 1366 prospectively recruited patients presenting to the ED with symptoms of suspected acute coronary syndrome (ACS) were stratified into groups at low, intermediate or high risk of an ACS...
August 4, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28984678/effect-of-branched-chain-amino-acid-supplements-on-muscle-strength-and-muscle-mass-in-patients-with-liver-cirrhosis
#20
Haruki Uojima, Seiko Sakurai, Hisashi Hidaka, Takeshi Kinbara, Ji Hyun Sung, Chikamasa Ichita, Shinnosuke Tokoro, Sakue Masuda, Akiko Sasaki, Kazuya Koizumi, Hideto Egashira, Makoto Kako, Shuzo Kobayashi
OBJECTIVE: The aim of this study was to assess the effect of branched-chain amino acid (BCAA) supplements on muscle strength and muscle mass in patients with liver cirrhosis. PATIENTS AND METHODS: We carried out a single-center, prospective study of adult cirrhotic patients receiving nutrition therapy at Shonan Kamakura General Hospital. A 28-day pretreatment observation period was followed by a 24-week treatment period. Patients who fulfilled the treatment criteria received one package of oral BCAA supplement powder twice a day and the response was evaluated...
October 3, 2017: European Journal of Gastroenterology & Hepatology
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