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https://www.readbyqxmd.com/read/28535624/-utilisation-of-electrical-impedance-tomography-and-or-ultrasound-and-mammography-in-breast-disease-diagnosis-a-controlled-study
#1
F Xu, M X Li, H Z Jusko, Hongchuan Jiang
Objective: To investigate the diagnostic accuracy of electrical impedance tomography (EIT) for benign and malignant breast diseases incomparison to conventional ultrasonography and mammography. Methods: A total of 121 patients with 126 breast lesions who underwent mammography ultrasonography and EIT were enrolled in the study. All of these lessions were were confirmed by pathological biopsy. The accuracy, sensitivity, specificity, positive predictive value and negative predictive value of EIT, ultrasonography and mammography were calculated with histology as the gold standard...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28533424/comparison%C3%A2-of%C3%A2-efficacy%C3%A2-and%C3%A2-safety%C3%A2-between%C3%A2-dezocine-and%C3%A2-morphine-for-persistence-of-pain-in-cancer-patients-in-chinese-a-meta-analysis
#2
Lei Wang, Xudong Liu, Jianfeng Wang, Yingjiao Sun, Guozhuan Zhang, Lishuang Liang
   The association between the efficacy and safety of dezocine injection and morphine injection for persistence of pain in patients with cancer had yielded controversial results. Therefore, we conduct a meta-analysis of existing observational published studies to assess the relationship between them among Chinese. We conducted a comprehensive research from the databases of PubMed, Web of Science and Wan Fang Med Online for the related studies up to October 2016. Summary odds ratio (OR) with 95% confidence interval (95% CI) were calculated with the random effects model...
May 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28532457/efficacy-of-chemotherapy-in-elderly-patients-with-unresectable-pancreatic-cancer-a-multicenter-review-of-895-patients
#3
Taira Kuroda, Teru Kumagi, Tomoyuki Yokota, Nobuaki Azemoto, Aki Hasebe, Hirotaka Seike, Mari Nishiyama, Nobu Inada, Naozumi Shibata, Hideki Miyata, Tomoe Kawamura, Yusuke Imai, Akiko Ueno-Toshimori, Yoshinori Tanaka, Takashi Terao, Yoshiki Imamura, Mitsuhito Koizumi, Hirofumi Yamanishi, Yoshinori Ohno, Yoichi Hiasa
BACKGROUND: The efficacy of chemotherapy for unresectable pancreatic cancer has improved. However, it is occasionally difficult to make treatment decisions for elderly patients. We reviewed the outcomes of elderly patients with unresectable pancreatic cancer by using a large cohort and evaluated whether they had received chemotherapy and the reason why. METHODS: Data for 895 pancreatic cancer patients who were treated using chemotherapy or best supportive care were analyzed considering demographics, clinical stage, treatment, and outcome...
May 22, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28531894/evaluation-of-absolute-serum-creatinine-changes-in-staging-of-cirrhosis-induced-acute-renal-injury-and-its-association-with-long-term-outcomes
#4
Fangfang Zhou, Qun Luo, Lina Han, Huadong Yan, Wenhong Zhou, Zemin Wang, Yumei Li
BACKGROUND/AIMS: To assess the prognostic accuracy of absolute serum creatinine (sCr) changes ('Delta-sCr') on the long-term outcomes in cirrhotic patients, and evaluate the performance of the 'Delta-sCr' approach to stage acute kidney injury (AKI), compared with the Kidney Disease Improving Global Outcomes (KDIGO) criteria. METHODS: We conducted a retrospective analysis of 333 hospitalized patients. We classified AKI stages using two methods: 1) KDIGO AKI criteria; 2) 'Delta-sCr' system, defined by the difference between the baseline and the peak sCr value during the hospitalization...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28530813/enhanced-sampling-of-phase-transitions-in-coarse-grained-lipid-bilayers
#5
David N Stelter, Tom Keyes
Freezing and melting of dipalmitoylphosphatidylcholine (DPPC) bilayers are simulated in both the explicit (Wet) and implicit solvent (Dry) coarse-grained MARTINI force fields with enhanced sampling, via the isobaric, molecular dynamics version of the generalized replica exchange method (gREM). Phase transitions are described with the entropic viewpoint, based upon the statistical temperature as a function of enthalpy, TS(H) = 1/(dS(H)/dH), where S is the configurational entropy. Bilayer thickness, area per lipid, and the second-rank order parameter (P2) are calculated vs temperature in the transition range...
May 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28530317/-long-term-survival-of-dual-disorders-patients-after-mixed-care-in-dual-disorders-and-standard-wards-versus-care-only-in-dual-disorders-ward
#6
Yuri Gimelfarb, Aviva Wolf, Mashit Ben-Tzarfati
BACKGROUND: Dual disorders (co-occurring mental illness and substance abuse disorders in the same person) are extremely common among patients receiving mental health services. Integrated treatment has been proposed as the standard of care and it describes a flexible combination of treatments from the mental health and addiction fields that are blended together in the therapy. Scientific evidence for survival of dual disorders patients (DDPs), who had integrated dual disorders inpatient care, is lacking...
January 2017: Harefuah
https://www.readbyqxmd.com/read/28526799/acquired-resistance-to-macrolides-in-pseudomonas-aeruginosa-from-cystic-fibrosis-patients
#7
Muhammad-Hariri Mustafa, Shaunak Khandekar, Michael M Tunney, J Stuart Elborn, Barbara C Kahl, Olivier Denis, Patrick Plésiat, Hamidou Traore, Paul M Tulkens, Francis Vanderbist, Françoise Van Bambeke
Cystic fibrosis (CF) patients receive chronic treatment with macrolides for their antivirulence and anti-inflammatory properties. We, however, previously showed that Pseudomonas aeruginosa, considered as naturally resistant to macrolides, becomes susceptible when tested in a eukaryotic medium rather than a conventional broth.We therefore looked for specific macrolide resistance determinants in 333 CF isolates from four European CF centres in comparison with 48 isolates from patients suffering from hospital-acquired pneumonia (HAP)...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28526448/the-catechol-o-methyltransferase-inhibitors-tolcapone-and-entacapone-uncouple-and-inhibit-the-mitochondrial-respiratory-chain-in-heparg-cells
#8
David Grünig, Andrea Felser, Jamal Bouitbir, Stephan Krähenbühl
The catechol-O-methyltransferase inhibitor tolcapone causes hepatotoxicity and mitochondrial damage in animal models. We studied the interaction of tolcapone with mitochondrial respiration in comparison to entacapone in different experimental models. In HepaRG cells (human cell-line), tolcapone decreased the ATP content (estimated IC50 100±15μM) and was cytotoxic (estimated IC50 333±45μM), whereas entacapone caused no cytotoxicity and no ATP depletion up to 200μM. Cytochrome P450 induction did not increase the toxicity of the compounds...
May 16, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28523515/distribution-of-exogenous-and-endogenous-cyp3a-markers-and-related-factors-in-healthy-males-and-females
#9
Jieon Lee, Andrew HyoungJin Kim, SoJeong Yi, SeungHwan Lee, Seo Hyun Yoon, Kyung-Sang Yu, In-Jin Jang, Joo-Youn Cho
Cytochrome P450 (CYP) 3A is an important drug-metabolizing enzyme in humans. Assessing CYP3A activity is necessary for predicting therapeutic outcomes or the potential adverse events of various therapeutics. This study sought to evaluate the distribution of endogenous and exogenous markers reflecting hepatic CYP3A activity and related factors affecting its activity in healthy male and female. Each subject was given a single 1 mg dose of midazolam intravenously. Pharmacokinetics, pharmacometabolomics, and pharmacogenomics analyses were performed to evaluate CYP3A activity...
May 18, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28521410/effect-of-momordica-charantia-protein-on-proliferation-apoptosis-and-the-akt-signal-transduction-pathway-in-the-human-endometrial-carcinoma-ishikawa-h-cell-line-in-vitro
#10
Hang-Zhi Gu, Rong-Rong Lin, Han-Chu Wang, Xue-Jie Zhu, Yan Hu, Fei-Yun Zheng
Endometrial carcinoma (EC) is one of the most common female malignancies, and there is an urgent requirement to explore new therapeutic strategies. In the present study, Ishikawa H cells were treated with Momordica charantia protein (MCP30). The cell morphology, growth inhibition rate, cell cycle distribution, and expression of phosphate and tensin homolog, P-AKT and AKT were measured. DNA fragmentation analysis and Annexin V-fluorescein isothiocyanate/propidium iodide double staining assay were used to analyze cell apoptosis...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28513293/effect-of-organic-matter-on-mobilization-of-antimony-from-nanocrystalline-titanium-dioxide
#11
Hailin Yang, Xiaofei Lu, Mengchang He
Antimony (Sb) is of increasing environmental concern worldwide. The sorption behavior of Sb was investigated. Both Sb(III) and Sb(V) were likely to be sorbed onto nanocrystalline titanium dioxide (TiO2). Sorption studies showed that the Sb(V) sorption capacity and rate for TiO2 were greater than those of Sb(III). The highest Sb(III) and Sb(V) sorption on TiO2, on the basis of the Langmuir equation, were 333 and 588 mmol kg(-1), respectively. The study suggested that TiO2 is an effective adsorbent for Sb removal...
May 17, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28513135/porous-mof-with-highly-efficient-selectivity-and-chemical-conversion-for-co2
#12
Hai-Hua Wang, Lei Hou, Yong-Zhi Li, Chen-Yu Jiang, Yao-Yu Wang, Zhonghua Zhu
A new Co(II)-based MOF, {[Co2(tzpa)(OH)(H2O)2]·DMF}n (1) (H3tzpa = 5-(4-(tetrazol-5-yl)phenyl)isophthalic acid), was constructed by employing a tetrazolyl-carboxyl ligand H3tzpa. 1 possesses 1D tubular channels that are decorated by μ3-OH groups, uncoordinated carboxylate O atoms, and open metal centers generated by the removal of coordinated water molecules, leading to high CO2 adsorption capacity and significantly selective capture for CO2 over CH4 and CO in the temperature range of 298-333 K. Moreover, 1 shows the chemical stability in acidic and basic aqueous solutions...
May 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28506252/the-impact-of-residential-status-on-cognitive-decline-among-older-adults-in-china-results-from-a-longitudinal-study
#13
Hanzhang Xu, Matthew E Dupre, Danan Gu, Bei Wu
BACKGROUND: Residential status has been linked to numerous determinants of health and well-being. However, the influence of residential status on cognitive decline remains unclear. The purpose of this research was to assess the changes of cognitive function among older adults with different residential status (urban residents, rural-to-urban residents, rural residents, and urban-to-rural residents), over a 12-year period. METHODS: We used five waves of data (2002, 2005, 2008/2009, 2011/2012, and 2014) from the Chinese Longitudinal Healthy Longevity Survey with 17,333 older adults age 65 and over who were interviewed up to five times...
May 15, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28505881/herbaceous-or-salix-miyabeana-sx64-narrow-buffer-strips-as-a-means-to-minimize-glyphosate-and-aminomethylphosphonic-acid-leaching-from-row-crop-fields
#14
Louise Hénault-Ethier, Marc Lucotte, Matthieu Moingt, Serge Paquet, Sophie Maccario, Élise Smedbol, Marcelo Pedrosa Gomes, Laurent Lepage, Philippe Juneau, Michel Labrecque
Glyphosate is the most widely used herbicide worldwide and is now frequently detected in surface waters of agricultural regions, notably in Quebec (Canada). Numerous legislations require vegetated riparian buffer strips (RBS) along agricultural streams. Quebec policy requires 3-meter-wide RBS. The present study evaluates the efficiency of narrow herbaceous and low- or high-density (33,333 and 55,556stumps/ha) willow, Salix miyabeana 'SX64', RBS, to minimize leaching of glyphosate and its main degradation product (AMPA) from agricultural fields to streams...
May 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28504872/comparing-student-and-staff-perceptions-of-the-educational-climate-in-spanish-dental-schools-using-the-dundee-ready-education-environment-measure
#15
I Tomás, A Aneiros, M A Casares-de-Cal, V Quintas, I Prada-López, C Balsa-Castro, L Ceballos, G Gómez-Moreno, C Llena, P López-Jornet, M C Machuca, J Palés
OBJECTIVE: To compare the perceptions of students and teachers of the "Educational Climate" (EC) in Spanish public dental schools. METHODS: A group of 1064 students and 354 teachers from six Spanish public dental schools responded to the DREEM questionnaire. This has 50 items grouped into five subscales: perception of learning (Learning); perception of teachers (Teachers); academic self-perceptions (Academic); perception of the atmosphere in the faculty (Atmosphere); and social self-perceptions (Social)...
May 15, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28502831/a-12-week-randomized-clinical-trial-investigating-the-potential-for-sucralose-to-affect-glucose-homeostasis
#16
V Lee Grotz, Xavier Pi-Sunyer, Daniel Porte, Ashley Roberts, J Richard Trout
The discovery of gut sweet taste receptors has led to speculations that non-nutritive sweeteners, including sucralose, may affect glucose control. A double-blind, parallel, randomized clinical trial, reported here and previously submitted to regulatory agencies, helps to clarify the role of sucralose in this regard. This was primarily an out-patient study, with 4-week screening, 12-week test, and 4-week follow-up phases. Normoglycemic male volunteers (47) consumed ∼333.3 mg encapsulated sucralose or placebo 3x/day at mealtimes...
May 11, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28501197/methylmercury-determination-in-seafood-by-photochemical-vapor-generation-capacitively-coupled-plasma-microtorch-optical-emission-spectrometry
#17
Eniko Covaci, Marin Senila, Michaela Ponta, Eugen Darvasi, Dorin Petreus, Maria Frentiu, Tiberiu Frentiu
A non-chromatographic method based on double liquid-liquid extraction and measurements by UV photochemical vapor generation capacitively coupled plasma microtorch optical emission spectrometry was developed and characterized for methylmercury determination in seafood. Samples were prepared following the procedure recommended in JRC Technical Report of European Commission formerly proposed for the determination of methylmercury in seafood by thermal decomposition atomic absorption spectrometry, namely confinement of Hg species in 47% HBr solution, extraction of CH3Hg(+) in toluene and back-extraction in 1% l-cysteine aqueous solution...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28498236/feasibility-of-transabdominal-cardiophrenic-lymphnode-dissection-in-advanced-ovarian-cancer-initial-experience-at-a-tertiary-center
#18
Annalisa Garbi, Vanna Zanagnolo, Nicoletta Colombo, Giovanni Aletti, Maria Teresa Achilarre, Luca Bocciolone, Fabio Landoni, Stefania Rizzo, Roberto Biffi, Angelo Maggioni
OBJECTIVES: The purpose of this retrospective report is to define the safety and feasibility, based on our preliminary experience, of surgical transdiaphragmatic resection of enlarged cardiophrenic lymph nodes (CPLNs), as a part of upfront debulking surgery. Supradiaphragmatic nodes located between the diaphragm and the heart are frequently a location for lymph node metastasis in advanced ovarian cancer, and their removal is aimed to obtain no gross residual disease at the primary cytoreductive surgery often requiring aggressive surgical procedures...
May 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28494061/association-between-hospital-volume-and-30-day-readmissions-following-transcatheter-aortic-valve-replacement
#19
Sahil Khera, Dhaval Kolte, Tanush Gupta, Andrew Goldsweig, Poonam Velagapudi, Ankur Kalra, Gilbert H L Tang, Wilbert S Aronow, Gregg C Fonarow, Deepak L Bhatt, Herbert D Aronow, Neal S Kleiman, Michael Reardon, Paul C Gordon, Barry Sharaf, J Dawn Abbott
Importance: With the approval of transcatheter aortic valve replacement (TAVR) for patients with severe symptomatic aortic stenosis at intermediate surgical risk, TAVR volume is projected to increase exponentially in the United States. The 30-day readmission rate for TAVR was recently reported at 17.9%. The association between institutional TAVR volume and the 30-day readmission metric has not been examined. Objective: To assess the association between hospital TAVR volume and 30-day readmission...
May 11, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28493327/burden-of-illness-and-healthcare-resource-use-in-us-patients-with-sporadic-inclusion-body-myositis
#20
Gorana Capkun, Aoife Callan, Haijun Tian, Zhongyuan Wei, Changgeng Zhao, Neetu Agashivala, Victoria Barghout
INTRODUCTION: We analyzed the burden of illness of sporadic Inclusion Body Myositis (sIBM) patients and the costs to the healthcare system. METHODS: A retrospective cohort analysis of 333 sIBM patients aged ≥50 years was performed using United States claims data. sIBM patients were matched in a 1:5 ratio to randomly selected individuals with ≥1 healthcare encounter within the year of index date. RESULTS: sIBM patients presented with higher rates of disease- and muscle-related conditions, such as myalgia, myositis, muscle weakness, dysphagia, pneumonia and falls...
May 10, 2017: Muscle & Nerve
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