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https://www.readbyqxmd.com/read/29138154/pharmacologic-management-of-chronic-neuropathic-pain-review-of-the-canadian-pain-society-consensus-statement
#1
REVIEW
Alex Mu, Erica Weinberg, Dwight E Moulin, Hance Clarke
OBJECTIVE: To provide family physicians with a practical clinical summary of the Canadian Pain Society (CPS) revised consensus statement on the pharmacologic management of neuropathic pain. QUALITY OF EVIDENCE: A multidisciplinary interest group within the CPS conducted a systematic review of the literature on the current treatments of neuropathic pain in drafting the revised consensus statement. MAIN MESSAGE: Gabapentinoids, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors are the first-line agents for treating neuropathic pain...
November 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29135926/proline-based-carbamates-as-cholinesterase-inhibitors
#2
Hana Pizova, Marketa Havelkova, Sarka Stepankova, Andrzej Bak, Tereza Kauerova, Violetta Kozik, Michal Oravec, Ales Imramovsky, Peter Kollar, Pavel Bobal, Josef Jampilek
Series of twenty-five benzyl (2S)-2-(arylcarbamoyl)pyrrolidine-1-carboxylates was prepared and completely characterized. All the compounds were tested for their in vitro ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and the selectivity of compounds to individual cholinesterases was determined. Screening of the cytotoxicity of all the compounds was performed using a human monocytic leukaemia THP-1 cell line, and the compounds demonstrated insignificant toxicity. All the compounds showed rather moderate inhibitory effect against AChE; benzyl (2S)-2-[(2-chlorophenyl)carbamoyl]pyrrolidine-1-carboxylate (IC50 = 46...
November 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29135221/superhydrophobic-low-hysteresis-patterning-chemistry-for-water-drop-manipulation
#3
Ting Dong, Thomas J McCarthy
A method for preparing superhydrophobic surfaces containing guiding lines that control water motion is described. The background surfaces exhibit contact angles of A/R = 173°/171° and the guiding lines are also hydrophobic (A/R = 104°/102°). The low contact angle hysteresis allows facile water motion. The sequence of steps used to prepare these surfaces is central to their success, was designed to minimize defects, and involves only two inexpensive and fluorine-free reagents: methyltrichlorosilane and dimethyldichlorosilane...
November 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29133815/lc-ms-guided-isolation-of-three-pairs-of-enantiomeric-alkaloids-from-macleaya-cordata-and-their-enantioseparations-antiproliferative-activity-apoptosis-inducing-property
#4
Chunmei Sai, Dahong Li, Shengge Li, Tong Han, Yongzhi Guo, Zhanlin Li, Huiming Hua
(±)-Macleayins F-H (1-3), three pairs of new enantiomeric alkaloid dimers, along with four known alkaloids (4-7) as their plausible biogenetic precursors, were isolated from the aerial parts of Macleaya cordata. Compounds 1-3 were obtained under the guidance of LC-MS investigation, and their structures were elucidated by analysis of the 1D and 2D NMR spectroscopic data. The racemic mixtures were successfully separated by chiral HPLC, and the absolute configurations of enantiomers were determined by electronic circular dichroism (ECD) spectroscopy...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133589/precision-oncology-beyond-targeted-therapy-combining-omics-data-with-machine-learning-matches-the-majority-of-cancer-cells-to-effective-therapeutics
#5
Michael Q Ding, Lujia Chen, Gregory F Cooper, Jonathan D Young, Xinghua Lu
Precision oncology involves identifying drugs that will effectively treat a tumor and then prescribing an optimal clinical treatment regimen. However, most first-line chemotherapy drugs do not have biomarkers to guide their application. For molecularly targeted drugs, using the genomic status of a drug target as a therapeutic indicator has limitations. In this study, machine learning methods (e.g., deep learning) were used to identify informative features from genome scale omics data and to train classifiers for predicting the effectiveness of drugs in cancer cell lines...
November 13, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29133168/autologous-granulation-tissue-tubes-for-replacement-of-urethral-defects-an-experimental-study-in-male-rabbits
#6
Shi-Wei Jiang, Zhong-Hua Xu, Yuan-Yuan Zhao, Lei Yan, Zun-Lin Zhou, Gang-Li Gu
INTRODUCTION: Tubularized urethroplasty is commonly performed in clinical practice using genital skin flaps, bladder mucosa, and buccal mucosa. However, the long-term effects are not satisfying, and donor site morbidities remain a problem. Besides, those grafts are unavailable with malignant conditions of the urinary tract, a history of lichen sclerosis, or oral disease. OBJECTIVE: An autologous granulation tissue tube of any required length and diameter can be produced by implanting foreign objects subcutaneously (Summary Fig...
October 31, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29132512/ultrasound-and-other-innovations-for-fluid-management-in-the-icu
#7
REVIEW
Mark Blum, Paula Ferrada
Ultrasound is a user-dependent tool that can help guide therapy. The use of ultrasound to guide central line placement decreases complication rates. Cardiac ultrasound can help with the diagnosis of cases of hypotension. Lung and pleura ultrasound is a useful adjunct for diagnosis causes of desaturation. Abdominal ultrasound can help in rapid visitation of fluid and intra-abdominal structures.
December 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/29132336/study-protocol-the-labor-progression-study-laps-does-the-use-of-a-dynamic-progression-guideline-in-labor-reduce-the-rate-of-intrapartum-cesarean-sections-in-nulliparous-women-a-multicenter-cluster-randomized-trial-in-norway
#8
Stine Bernitz, Rebecka Dalbye, Pål Øian, Jun Zhang, Torbjørn Moe Eggebø, Ellen Blix
BACKGROUND: The increasing rate of intrapartum cesarean sections is subject of attention and concern as it is associated with adverse outcomes. Labor dystocia is one of the most frequent indications for cesarean sections even though there is no consensus on criteria for labor dystocia. Traditionally the progression of labor follows guidelines based on Friedman's curve from the mid 1950s. In 2010 Zhang presented a new labor curve and a dynamic guideline for labor progression based on contemporary research...
November 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29132294/artificial-selection-for-odor-guided-behavior-in-drosophila-reveals-changes-in-food-consumption
#9
Elizabeth B Brown, Cody Patterson, Rayanne Pancoast, Stephanie M Rollmann
BACKGROUND: The olfactory system enables organisms to detect chemical cues in the environment and can signal the availability of food or the presence of a predator. Appropriate behavioral responses to these chemical cues are therefore important for organismal survival and can influence traits such as organismal life span and food consumption. However, understanding the genetic mechanisms underlying odor-guided behavior, correlated responses in other traits, and how these constrain or promote their evolution, remain an important challenge...
November 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29129934/improved-shape-for-refinable-surfaces-with-singularly-parameterized-irregularities
#10
Kęstutis Karčiauskas, Jörg Peters
To date, singularly-parameterized surface constructions suffer from poor highlight line distributions, ruling them out as a surface representation of choice for primary design surfaces. This paper explores graded, many-piece, everywhere C(1) singularly-parameterized surface caps that mimic the shape of a high-quality guide surface. The approach illustrates the trade-off between polynomial degree and surface quality. For bi-degree 5, minor flaws in the highlight line distribution are still visible when zooming in on the singularity, but the distribution is good at the macroscopic level...
September 2017: Computer Aided Design
https://www.readbyqxmd.com/read/29127645/remote-monitoring-of-pulmonary-artery-pressures-with-cardiomems-in-patients-with-chronic-heart-failure-and-nyha-class%C3%A2-iii-first-experiences-in-the-netherlands
#11
REVIEW
J J Brugts, O C Manintveld, N van Mieghem
We report the first patient experiences with the CardioMEMS device in the Erasmus MC Thorax Center in the Netherlands. In line with clinical trial evidence, the device is applicable in patients with chronic heart failure in functional New York Heart Association class III with at least 1 admission for heart failure in the past 12 months. CardioMEMS has been shown to be safe and reliable, and effective in reducing the number of hospitalisations for heart failure by guided therapy based on pulmonary artery pressures...
November 10, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29127555/continuous-monitoring-of-blood-pressure-by-analyzing-the-blood-flow-sound-of-arteriovenous-fistula-in-hemodialysis-patients
#12
Yuka Kamijo, Eiichiro Kanda, Hayato Horiuchi, Noriyuki Kounoue, Keisuke Ono, Keizo Maeda, Akane Yanai, Kazuya Honda, Ryuji Tsujimoto, Mai Yanagi, Yoshitaka Ishibashi, Masayuki Yoshida
BACKGROUND: Patients with end-stage renal disease undergoing hemodialysis (HD) have an elevated risk of cardiovascular disease-related morbidity and mortality. To prevent from such a life-threatening event, the continuous blood pressure (BP) monitoring system may contribute to detect BP decline in early stages and may help to do appropriate disposal. Our research team has introduced an electronic stethoscope (Asahi Kasei Co, Ltd., Tokyo, Japan), which translates sound intensity of Arteriovenous Fistula (AVF) to BP data using the technique of Fourier transformation that can predict continuous BP non-invasively...
November 10, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29118265/a-systematic-review-of-health-related-quality-of-life-reporting-in-ovarian-cancer-phase-iii-clinical-trials-room-to-improve
#13
REVIEW
Michelle K Wilson, Michael L Friedlander, Florence Joly, Amit M Oza
BACKGROUND: Epithelial ovarian cancer (OC) remains a significant cause of morbidity and mortality for women worldwide. Patients may experience a multitude of disease- and treatment-related symptoms that can impact quality of life (QOL) and should be measured and reported in clinical trials. This systematic review investigated the adequacy of reporting of QOL in randomized phase III trials in OC in both the first-line and recurrent disease setting. MATERIALS AND METHODS: A systematic review of MEDLINE and EMBASE identified randomized clinical trials of systemic therapy in OC from 1980 to 2014...
November 8, 2017: Oncologist
https://www.readbyqxmd.com/read/29118224/exceptional-response-to-temsirolimus-in-a-metastatic-clear-cell-renal-cell-carcinoma-with-an-early-novel-mtor-activating-mutation
#14
Juan Francisco Rodríguez-Moreno, María Apellaniz-Ruiz, Juan María Roldan-Romero, Ignacio Durán, Luis Beltrán, Cristina Montero-Conde, Alberto Cascón, Mercedes Robledo, Jesus García-Donas, Cristina Rodríguez-Antona
mTOR pathway inhibitors are important drugs for the treatment of advanced renal cell carcinoma (RCC). However, no valid predictive markers have been identified to guide treatment selection and identify patients who are sensitive to these drugs. Mutations activating the mTOR pathway have been suggested to predict response; however, their predictive value is still unclear. Here, we present the genomic and functional characterization of a patient with metastatic clear cell RCC (ccRCC) who experienced a partial response to temsirolimus after a poor response to 2 previous lines of treatment...
November 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29117722/endoscopic-ultrasound-guided-pancreatic-fluid-collections-transmural-drainage-outcomes-in-100-consecutive-cases-of-pseudocysts-and-walled-off-necrosis-a-single-centre-experience-from-the-united-kingdom
#15
Chander Shekhar, Ben Maher, Colm Forde, Brinder Singh Mahon
BACKGROUND AND AIM: Endoscopic ultrasound-guided drainage is a minimally invasive first-line modality for the drainage of pancreatic fluid collection (PFC) resulting in a shorter hospital stay and less morbidity compared with surgical cystogastrostomy. Our aim is to evaluate potential differences in the outcomes of endoscopic ultrasound (EUS) guided transmural drainage (EUS-TD) drainage of pancreatic pseudocyst (PP) and walled-off necrosis (WON). METHOD: We retrospectively reviewed 100 consecutive EUS-guided drainages of PFC utilising EUS reports; clinical notes and imaging with follow-up (FU) to 12 months...
November 9, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29117473/largazole-analogues-as-histone-deacetylases-inhibitors-and-anticancer-agents-an-overview-on-structure-activity-relationships
#16
Giulio Poli, Romano Di Fabio, Luca Ferrante, Vincenzo Summa, Maurizio Botta
Since the time of its identification, the natural compound largazole rapidly caught the attention of the medicinal chemistry community for its impressive potency as histone deacetylases (HDACs) inhibitor and its strong antiproliferative activity against a broad panel of cancer cell lines. The design of largazole analogues is an expanding field of study, due to their remarkable potential as novel anticancer therapeutics. At present, a large ensemble of largazole analogues has been reported in literature, thus allowing the identification of important structure-activity relationships (SAR) that can guide the design of novel compounds with improved HDAC inhibitory profile, anticancer activity and pharmacokinetic properties...
November 8, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29116949/couples-experiences-with-healthy-lifestyle-behaviors-after-cardiac-rehabilitation
#17
Sheri A Rowland, Karen L Schumacher, Dee Dee Leinen, Brenda G Phillips, Paula S Schulz, Bernice C Yates
PURPOSE: Many cardiac patients discontinue heart-healthy eating and physical activity (PA) behaviors in the months following cardiac rehabilitation (CR). Involving the spouse in CR with the patient may be 1 strategy to increase the maintenance of these behaviors after CR. Assisting patients and spouses with the maintenance of healthy eating and PA behavior following CR begins with a better understanding of the couple-focused factors, impacting their experiences with these behaviors. The purpose of this study was to qualitatively examine couple-focused facilitators and barriers to maintaining changes in healthy eating and PA behavior from the perspectives of both cardiac patients and their spouses following phase 2 CR...
November 7, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29116075/-differential-alternative-splicing-in-brain-regions-of-rats-selected-for-aggressive-behavior
#18
V N Babenko, A O Bragin, I V Chadaeva, A L Markel, Y L Orlov
Profiles of alternative mRNA isoforms have been determined in three brain regions of rats from an aggressive and a tame line selected for 74 generations. Among 2319 genes with alternatively spliced exons, approximately 84% were confirmed by analyzing public databases. Based on Gene Ontology-guided clustering of alternatively spliced genes, it has been found that the sample was enriched in synapse-specific genes (FDR < 10^(-17)). Patterns of gene expression in the brains of animals with genetically determined high or low aggression were more frequently found to differ in the use of alternatively spliced exons than in animals environmentally conditioned for increased or lowered propensity to aggression...
September 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29115831/bacilotetrins-a-and-b-anti-staphylococcal-cyclic-lipotetrapeptides-from-a-marine-derived-bacillus-subtilis
#19
Fakir Shahidullah Tareq, Hee Jae Shin
LC-MS and NMR spectroscopy guided metabolic profiling and dereplication of a crude extract obtained from the fermentation of a marine-derived bacterium, Bacillus subtilis, followed by chromatographic isolation yielded two new cyclic-lipotetrapeptides, bacilotetrins A (1) and B (2). Based on extensive 1D and 2D NMR and high-resolution ESIMS data analysis, the structures of 1 and 2 were elucidated, revealing the unique structures of these lipopeptides consisting of three leucines and a glutamic acid residue cyclized with a lipophilic 3-hydroxy fatty acid...
November 8, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29115582/passenger-strand-of-mir-145-3p-acts-as-a-tumor-suppressor-by-targeting-myo1b-in-head-and-neck-squamous-cell-carcinoma
#20
Yasutaka Yamada, Keiichi Koshizuka, Toyoyuki Hanazawa, Naoko Kikkawa, Atsushi Okato, Tetsuya Idichi, Takayuki Arai, Sho Sugawara, Koji Katada, Yoshitaka Okamoto, Naohiko Seki
Analysis of the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC) based on RNA sequencing showed that dual strands of pre‑miR‑145 (miR‑145‑5p, guide strand; and miR‑145‑3p, passenger strand) were significantly reduced in cancer tissues. In miRNA biogenesis, passenger strands of miRNAs are degraded and have no biological activities in cells. The aims of this study were to investigate the functional significance of the passenger strand of miR‑145 and to identify miR‑145‑3p‑regulated oncogenic genes in HNSCC cells...
November 6, 2017: International Journal of Oncology
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