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https://www.readbyqxmd.com/read/27906234/generation-of-spectral-clusters-in-a-mixture-of-noble-and-raman-active-gases
#1
Pooria Hosseini, Amir Abdolvand, Philip St J Russell
We report a novel scheme for the generation of dense clusters of Raman sidebands. The scheme uses a broadband-guiding hollow-core photonic crystal fiber (HC-PCF) filled with a mixture of H<sub>2</sub>, D<sub>2</sub>, and Xe for efficient interaction between the gas mixture and a green laser pump pulse (532 nm, 1 ns) of only 5 μJ of energy. This results in the generation from noise of more than 135 rovibrational Raman sidebands covering the visible spectral region with an average spacing of only 2...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27904452/virtual-modelling-of-novel-applicator-prototypes-for-cervical-cancer-brachytherapy
#2
Primoz Petric, Robert Hudej, Noora Al-Hammadi, Barbara Segedin
BACKGROUND: Standard applicators for cervical cancer Brachytherapy (BT) do not always achieve acceptable balance between target volume and normal tissue irradiation. We aimed to develop an innovative method of Target-volume Density Mapping (TDM) for modelling of novel applicator prototypes with optimal coverage characteristics. Patients and methods. Development of Contour-Analysis Tool 2 (CAT-2) software for TDM generation was the core priority of our task group. Main requests regarding software functionalities were formulated and guided the coding process...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27903528/consensus-guidelines-for-the-diagnosis-and-management-of-patients-with-classic-hairy-cell-leukemia
#3
Michael R Grever, Omar Abdel-Wahab, Leslie A Andritsos, Versha Banerji, Jacqueline Barrientos, James S Blachly, Timothy G Call, Daniel Catovsky, Claire Dearden, Judit Demeter, Monica Else, Francesco Forconi, Alessandro Gozzetti, Anthony D Ho, James B Johnston, Jeffrey Jones, Gunnar Juliusson, Eric Kraut, Robert J Kreitman, Loree Larratt, Francesco Lauria, Gerard Lozanski, Emili Montserrat, Sameer A Parikh, Jae H Park, Aaron Polliack, Graeme R Quest, Kanti R Rai, Farhad Ravandi, Tadeusz Robak, Alan Saven, John F Seymour, Tamar Tadmor, Martin S Tallman, Constantine Tam, Enrico Tiacci, Xavier Troussard, Clive S Zent, Thorsten Zenz, Pier Luigi Zinzani, Brunangelo Falini
Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate approach to re-treatment present continuing areas for research. The disease and its effective treatment are associated with immunosuppression. As more patients are being treated with alternative programs, comparison of results will require general agreement on definitions of response, relapse, and methods of determining minimal residual disease...
November 30, 2016: Blood
https://www.readbyqxmd.com/read/27903005/vanishing-point-attracts-gaze-in-free-viewing-and-visual-search-tasks
#4
Ali Borji, Mengyang Feng, Huchuan Lu
Several structural scene cues such as gist, layout, horizontal line, openness, and depth have been shown to guide scene perception (e.g., Oliva & Torralba, 2001); Ross & Oliva, 2009). Here, to investigate whether vanishing point (VP) plays a significant role in gaze guidance, we ran two experiments. In the first one, we recorded fixations of 10 observers (six male, four female; mean age 22; SD = 0.84) freely viewing 532 images, out of which 319 had a VP (shuffled presentation; each image for 4 s). We found that the average number of fixations at a local region (80 × 80 pixels) centered at the VP is significantly higher than the average fixations at random locations (t test; n = 319; p < 0...
November 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/27902778/an-insecticide-further-enhances-experience-dependent-increased-behavioural-responses-to-sex-pheromone-in-a-pest-insect
#5
Antoine Abrieux, Amel Mhamdi, Kaouther K Rabhi, Julie Egon, Stéphane Debernard, Line Duportets, Hélène Tricoire-Leignel, Sylvia Anton, Christophe Gadenne
Neonicotinoid insecticides are widely used to protect plants against pest insects, and insecticide residues remaining in the environment affect both target and non-target organisms. Whereas low doses of neonicotinoids have been shown to disturb the behaviour of pollinating insects, recent studies have revealed that a low dose of the neonicotinoid clothianidin can improve behavioural and neuronal sex pheromone responses in a pest insect, the male moth Agrotis ipsilon, and thus potentially improve reproduction...
2016: PloS One
https://www.readbyqxmd.com/read/27900510/does-a-positioning-rod-or-a-patient-specific-guide-result-in-more-natural-femoral-flexion-in-the-concept-of-kinematically-aligned-total-knee-arthroplasty
#6
Max Ettinger, Tilman Calliess, Stephen M Howell
PURPOSE: Flexion of the femoral component in 5° increments downsizes the femoral component, decreases the proximal reach and surface area of the trochlea, delays the engagement of the patella during flexion, and is associated with a higher risk of patellar-femoral instability after kinematically aligned TKA. The present study evaluated flexion of the femoral component after use of two kinematic alignment instrumentation systems. We determined whether a distal cutting block attached to a positioning rod inserted perpendicular to the distal femoral joint line in the axial plane and 8-10 cm into the distal femur anterior and posterior to the distal cortex of the femur in the sagittal plane or a femoral patient-specific cutting guide sets the femoral component in more natural flexion...
November 29, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27899330/mr-visible-localization-device-for-radiographic-pathologic-correlation-of-surgical-specimens
#7
Sonja Kinner, Tilman B Schubert, Elisabetta A Nocerino, Shannon Hynes, Timothy J Colgan, Agnes G Loeffler, Christopher Brace, Scott B Reeder, Emily Winslow
PURPOSE: The detection of small parenchymal hepatic lesions identified by preoperative imaging remains a challenge for traditional pathologic methods in large specimens. We developed a magnetic resonance imaging (MRI) compatible localization device for imaging of surgical specimens aimed to improve identification and localization of hepatic lesions ex vivo. MATERIALS AND METHODS: The device consists of two stationary and one removable MR-visible grids lined with silicone gel, creating an orthogonal 3D matrix for lesion localization...
November 26, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27898833/a-cluster-of-nucleotide-binding-site-leucine-rich-repeat-genes-resides-in-a-barley-powdery-mildew-resistance-quantitative-trait-loci-on-7hl
#8
Carlos P Cantalapiedra, Bruno Contreras-Moreira, Cristina Silvar, Dragan Perovic, Frank Ordon, María Pilar Gracia, Ernesto Igartua, Ana M Casas
Powdery mildew causes severe yield losses in barley production worldwide. Although many resistance genes have been described, only a few have already been cloned. A strong QTL (quantitative trait locus) conferring resistance to a wide array of powdery mildew isolates was identified in a Spanish barley landrace on the long arm of chromosome 7H. Previous studies narrowed down the QTL position, but were unable to identify candidate genes or physically locate the resistance. In this study, the exome of three recombinant lines from a high-resolution mapping population was sequenced and analyzed, narrowing the position of the resistance down to a single physical contig...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27898297/a-novel-pfib-sample-preparation-protocol-for-correlative-3d-x-ray-cnt-and-fib-tof-sims-tomography
#9
Agnieszka Priebe, Guillaume Audoit, Jean-Paul Barnes
We present a novel sample preparation method that allows correlative 3D X-ray Computed Nano-Tomography (CNT) and Focused Ion Beam Time-Of-Flight Secondary Ion Mass Spectrometry (FIB-TOF-SIMS) tomography to be performed on the same sample. In addition, our invention ensures that samples stay unmodified structurally and chemically between the subsequent experiments. The main principle is based on modifying the topography of the X-ray CNT experimental setup before FIB-TOF-SIMS measurements by incorporating a square washer around the sample...
November 19, 2016: Ultramicroscopy
https://www.readbyqxmd.com/read/27895879/evaluation-of-stress-scores-throughout-radiological-biopsies
#10
Ozlem Turkoglu, Hasan Huseyin Mutlu
BACKGROUND: Ultrasound-guided biopsy procedures are the most prominent methods that increase the trauma, stress and anxiety experienced by the patients. OBJECTIVES: Our goal was to examine the level of stress in patients waiting for radiologic biopsy procedures and determine the stress and anxiety level arising from waiting for a biopsy procedure. PATIENTS AND METHODS: This prospective study included 35 female and 65 male patients who were admitted to the interventional radiology department of Kartal Dr...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27893171/salvage-therapy-in-first-relapse-a-retrospective-study-in-a-large-patient-population-with-multiple-myeloma
#11
Massimo Offidani, Laura Corvatta, Sara Bringhen, Silvia Gentili, Rossella Troia, Laura Maracci, Alessandra Larocca, Pietro Leoni, Mario Boccadoro
OBJECTIVE: there is no strong evidence to guide therapeutic approach to multiple myeloma (MM) patients who experience first relapse. The treatment choice can be difficult since currently all patients are exposed to novel agents as thalidomide, bortezomib and lenalidomide. METHODS: in this retrospective analysis we evaluated the best therapeutic sequence, the role of re-treatment and the most beneficial cut-off of first remission in order to choose re-treatment, analyzing 476 patients relapsed after first-line therapy...
November 28, 2016: European Journal of Haematology
https://www.readbyqxmd.com/read/27890583/ailanthusins-a-g-and-nor-lupane-triterpenoids-from-ailanthus-triphysa
#12
Sanit Thongnest, Jutatip Boonsombat, Hunsa Prawat, Chulabhorn Mahidol, Somsak Ruchirawat
Bioactivity-guided chemical investigation of the CH2Cl2 and CH2Cl2MeOH extracts of the stem and stem bark material of Ailanthus tryphysa (Simaroubaceae) led to the isolation of five cycloapotirucallanes, ailanthusins A-E, two malabaricanes, ailanthusins F-G, and one nor-lupane triterpenoid, 29-nor-lup-1-ene-3,20-dione along with twenty known compounds. Their structures were elucidated through the application of extensive spectroscopic methods, and the structure of ailanthusin A was further confirmed by single crystal X-ray analysis...
November 24, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27890325/functional-coupling-between-frontoparietal-and-occipitotemporal-pathways-during-action-and-perception
#13
R Matthew Hutchison, Jason P Gallivan
Several lines of evidence point to areas in the occipitotemporal pathway as being critical in the processes of visual perception and object recognition. Much less appreciated, however, is the role that this pathway plays in object-related processing for the purposes of visually guided action. Here, using functional MRI (fMRI) and functional connectivity (FC) measures, we examined interactions between areas in frontoparietal cortex (FPC) involved in grasping, reaching, eye movements, and tool use and areas in occipitotemporal cortex (OTC) involved in object-, face-, scene-, body-, tool-, and motion-related processing, both during the performance of sensorimotor and visual-perceptual tasks, as well as during passive fixation (resting-state)...
November 9, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27887609/cytotoxic-effects-of-ergone-a-compound-isolated-from-fulviformes-fastuosus
#14
Dilusha Fernando, Achyut Adhikari, Chandrika Nanayakkara, E Dilip de Silva, Ravi Wijesundera, Preethi Soysa
BACKGROUND: Mushrooms inspired the cuisines of many cultures and conventional medicaments for cancer. However, a substantial number of mushroom species are yet unexplored, possessing an unknown chemical, biological and pharmacological profiles. Fulviformes fastuosus is a terrestrial mushroom, which is commonly found in Sri Lankan woodlands. The current study was aimed at isolation and characterization of a potent cytotoxic compound from F. fastuosus and investigating the apoptotic effect induced by the active principle against cancer and normal cell lines...
November 25, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27887587/experiences-of-support-in-working-toward-personal-recovery-goals-a-collaborative-qualitative-study
#15
Eva Biringer, Larry Davidson, Bengt Sundfør, Torleif Ruud, Marit Borg
BACKGROUND: Recovery can be understood as a subjective process guided by personal expectations, goals and hopes. The aim of the study was to explore how persons using a Community Mental Health Centre (CMHC) experienced that their expectations for treatment, and goals and hopes for recovery were supported by the health professionals during treatment. METHODS: Employing a hermeneutic-phenomenological approach, eight service users were interviewed about their expectations for treatment and their goals and hopes for recovery at the start of their contact with health professionals at a CMHC...
November 25, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27885861/additional-synthesis-on-thiophene-containing-trisubstituted-methanes-trsms-as-inhibitors-of-m-tuberculosis-and-3d-qsar-studies
#16
P Singh, T Saha, P Mishra, M K Parai, S Ireddy, S Lavanya Kumar M, S Krishna, S K Kumar, V Chaturvedi, S Sinha, M I Siddiqi, G Panda
We earlier reported thiophene-containing trisubstituted methanes (TRSMs) as novel cores carrying anti-tubercular activity, and identified S006-830 as the phenotypic lead with potent bactericidal activity against single- and multi-drug resistant clinical isolates of Mycobacterium tuberculosis (M. tb). In this work, we carried out additional synthesis of several TRSMs. The reaction scheme essentially followed the Grignard reaction and Friedel-Crafts alkylation, followed by insertion of a dialkylaminoethyl chain...
November 2016: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/27885434/evaluation-of-mir-21-and-mir-375-as-prognostic-biomarkers-in-oesophageal-cancer-in-high-risk-areas-in-china
#17
Yutong He, Jing Jin, LiQun Wang, Yuejiao Hu, Di Liang, Huichai Yang, Yueping Liu, Baoen Shan
MicroRNAs have been associated with prognosis in oesophageal cancer (EC), suggesting that miRNAs could play a role in guiding treatment decisions. The aim of this study was to evaluate the prognostic potential of miRNAs found to be associated with zinc deficiency in a geographical area with a high incidence of EC. miRNAs found to be associated with zinc deficiency were isolated from EC cell lines cultured with various Zn levels. The expression levels of the miRNAs were quantified using qRT-PCR. The potential prognostic value of the selected miRNAs was assessed in a cohort study of 88 patients from an area in China with a high incidence of EC...
November 24, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27883890/a-consensus-genome-scale-reconstruction-of-chinese-hamster-ovary-cell-metabolism
#18
Hooman Hefzi, Kok Siong Ang, Michael Hanscho, Aarash Bordbar, David Ruckerbauer, Meiyappan Lakshmanan, Camila A Orellana, Deniz Baycin-Hizal, Yingxiang Huang, Daniel Ley, Veronica S Martinez, Sarantos Kyriakopoulos, Natalia E Jiménez, Daniel C Zielinski, Lake-Ee Quek, Tune Wulff, Johnny Arnsdorf, Shangzhong Li, Jae Seong Lee, Giuseppe Paglia, Nicolas Loira, Philipp N Spahn, Lasse E Pedersen, Jahir M Gutierrez, Zachary A King, Anne Mathilde Lund, Harish Nagarajan, Alex Thomas, Alyaa M Abdel-Haleem, Juergen Zanghellini, Helene F Kildegaard, Bjørn G Voldborg, Ziomara P Gerdtzen, Michael J Betenbaugh, Bernhard O Palsson, Mikael R Andersen, Lars K Nielsen, Nicole Borth, Dong-Yup Lee, Nathan E Lewis
Chinese hamster ovary (CHO) cells dominate biotherapeutic protein production and are widely used in mammalian cell line engineering research. To elucidate metabolic bottlenecks in protein production and to guide cell engineering and bioprocess optimization, we reconstructed the metabolic pathways in CHO and associated them with >1,700 genes in the Cricetulus griseus genome. The genome-scale metabolic model based on this reconstruction, iCHO1766, and cell-line-specific models for CHO-K1, CHO-S, and CHO-DG44 cells provide the biochemical basis of growth and recombinant protein production...
November 23, 2016: Cell Systems
https://www.readbyqxmd.com/read/27882677/utility-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-diagnosing-non-specific-inflammatory-intrathorcacic-lymphadenitis
#19
Huizhen Yang, Shenglan Wang, Jiajun Teng, Baohui Han, Jiayuan Sun
BACKGROUND AND OBJECTIVE: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a minimally invasive technique for diagnosing intrathoracic malignancies and some benignancies; however, there are no data available on the utility of EBUS-TBNA for the diagnosis of non-specific inflammatory intrathoracic lymphadenitis. METHODS: A prospective analysis was performed from 104 patients with enlarged lymphadenopathy suspected of non-specific lymphadenitis referred for EBUS-TBNA between October 2009 and March 2012...
November 7, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27881314/orientation-of-handle-for-successful-prosthetic-treatment-in-patients-with-an-anatomic-compromise-after-a-maxillectomy
#20
Yuka I Sumita, Mariko Hattori, Mahmoud E Elbashti, Hisashi Taniguchi
This clinical technique provides a key procedure for successful prosthetic treatment in patients with an anatomical compromise after a maxillectomy. When making a preliminary impression, the clinician must keep the handle of the stock tray parallel to the patient's interpupillary line extraorally to maintain the correct position of the tray and to make a record of the inclination of the occlusal plane. This simple consideration during this first step of making a preliminary impression can be an important guide for both dentists and dental technicians...
October 27, 2016: Journal of Prosthetic Dentistry
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