Seetha Shankaran, Athina Pappas, Scott A McDonald, Abbot R Laptook, Rebecca Bara, Richard A Ehrenkranz, Jon E Tyson, Ronald Goldberg, Edward F Donovan, Avroy A Fanaroff, Abhik Das, W Kenneth Poole, Michele Walsh, Rosemary D Higgins, Cherie Welsh, Walid Salhab, Waldemar A Carlo, Brenda Poindexter, Barbara J Stoll, Ronnie Guillet, Neil N Finer, David K Stevenson, Charles R Bauer
OBJECTIVE: To examine the predictive validity of the amplitude integrated electroencephalogram (aEEG) and stage of encephalopathy among infants with hypoxic-ischemic encephalopathy (HIE) eligible for therapeutic whole-body hypothermia. DESIGN: Neonates were eligible for this prospective study if moderate or severe HIE occurred at <6 hours and an aEEG was obtained at <9 hours of age. The primary outcome was death or moderate/severe disability at 18 months. RESULTS: There were 108 infants (71 with moderate HIE and 37 with severe HIE) enrolled in the study...
July 2011: Pediatrics