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Early EEG Findings in Hypoxic-Ischemic Encephalopathy 

Young-Ah Youn, Ji Hoon Kim, Sook-Kyung Yum, Cheong-Jun Moon, In-Goo Lee, In Kyung Sung
BACKGROUND AND OBJECTIVE: The incidence of hypoxic ischemic encephalopathy (HIE) in developed countries is estimated to be 1.5 per 1000 live births. The primary aim of this study was to analyze whether earlier hypothermia (≤1 h) improves hospital outcomes in survivors who underwent therapeutic hypothermia (TH) when compared with late TH (>1 h). METHOD: Forty-nine (70%) newborns received TH for 72 h, within 6 h of birth; the remaining 21 received standard care...
2016: Journal of Maternal-fetal & Neonatal Medicine
Tania Nanavati, Nirupama Seemaladinne, Michael Regier, Panitan Yossuck, Paola Pergami
BACKGROUND: Neonatal hypoxic ischemic encephalopathy (HIE) is a major cause of mortality, morbidity, and long-term neurological deficits. Despite the availability of neuroimaging and neurophysiological testing, tools for accurate early diagnosis and prediction of developmental outcome are still lacking. The goal of this study was to determine if combined use of magnetic resonance imaging (MRI) and electroencephalography (EEG) findings could support outcome prediction. METHODS: We retrospectively reviewed records of 17 HIE neonates, classified brain MRI and EEG findings based on severity, and assessed clinical outcome up to 48 months...
October 2015: Pediatrics and Neonatology
H Aly, H Elmahdy, M El-Dib, M Rowisha, M Awny, T El-Gohary, M Elbatch, M Hamisa, A-R El-Mashad
OBJECTIVE: Melatonin has been shown to be neuroprotective in animal models. The objective of this study is to examine the effect of melatonin on clinical, biochemical, neurophysiological and radiological outcomes of neonates with hypoxic-ischemic encephalopathy (HIE). STUDY DESIGN: We conducted a prospective trial on 45 newborns, 30 with HIE and 15 healthy controls. HIE infants were randomized into: hypothermia group (N=15; received 72-h whole-body cooling) and melatonin/hypothermia group (N=15; received hypothermia and five daily enteral doses of melatonin 10 mg kg(-1))...
March 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
Paolo Zanatta, Simone Messerotti Benvenuti, Fabrizio Baldanzi, Matteo Bendini, Marsilio Saccavini, Wadih Tamari, Daniela Palomba, Enrico Bosco
This case series investigates whether painful electrical stimulation increases the early prognostic value of both somatosensory-evoked potentials and functional magnetic resonance imaging in comatose patients after cardiac arrest. Three single cases with hypoxic-ischemic encephalopathy were considered. A neurophysiological evaluation with an electroencephalogram and somatosensory-evoked potentials during increased electrical stimulation in both median nerves was performed within five days of cardiac arrest...
2012: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Kıvılcım Gucuyener, Serdar Beken, Ebru Ergenekon, Sebnem Soysal, Ibrahim Hirfanoglu, Ozden Turan, Sezin Unal, Nilgün Altuntas, Ebru Kazanci, Ferit Kulali, Esin Koc, Canan Turkyilmaz, Esra Onal, Yıldız Atalay
BACKGROUND: Amplitude-integrated electroencephalogram (aEEG) at <6 h is the best single outcome predictor in term infants with perinatal asphyxia at normothermia. Hypothermia treatment has changed the cutoff values for outcome prediction by using time at onset of normal trace and SWC. Cerebral hemodynamics and oxygenation changes detected by near infrared spectroscopy (NIRS) during hypothermia treatment in aphyxiated neonates are not a well known issue. AIM: The aim of this study was to investigate the correlations between brain monitoring (amplitude integrated EEG and NIRS) and outcome in asphyxiated full-term infants with moderate/severe hypoxic-ischemic encephalopathy before, during and after hypothermia treatment...
April 2012: Brain & Development
Seetha Shankaran, Athina Pappas, Scott A McDonald, Abbot R Laptook, Rebecca Bara, Richard A Ehrenkranz, Jon E Tyson, Ronald Goldberg, Edward F Donovan, Avroy A Fanaroff, Abhik Das, W Kenneth Poole, Michele Walsh, Rosemary D Higgins, Cherie Welsh, Walid Salhab, Waldemar A Carlo, Brenda Poindexter, Barbara J Stoll, Ronnie Guillet, Neil N Finer, David K Stevenson, Charles R Bauer
OBJECTIVE: To examine the predictive validity of the amplitude integrated electroencephalogram (aEEG) and stage of encephalopathy among infants with hypoxic-ischemic encephalopathy (HIE) eligible for therapeutic whole-body hypothermia. DESIGN: Neonates were eligible for this prospective study if moderate or severe HIE occurred at <6 hours and an aEEG was obtained at <9 hours of age. The primary outcome was death or moderate/severe disability at 18 months. RESULTS: There were 108 infants (71 with moderate HIE and 37 with severe HIE) enrolled in the study...
July 2011: Pediatrics
Deirdre M Murray, Geraldine B Boylan, Cornelius A Ryan, Sean Connolly
OBJECTIVE: We examined the evolution of electroencephalographic (EEG) changes after hypoxic injury. METHODS: Continuous, multichannel, video-EEG was recorded for term infants with hypoxic-ischemic encephalopathy, from <6 hours to 72 hours after delivery. One-hour segments at 6, 12, 24, and 48 hours of age of the EEG were analyzed visually, and neurologic outcome was assessed at 24 months. RESULTS: Forty-four infants completed neurodevelopmental follow-up...
September 2009: Pediatrics
Federico Allemand, Federica Reale, Marco Sposato, Alessandro Allemand
BACKGROUND: The issue concerning neurologic outcome in patients with perinatal Hypoxic-Ischemic Encephalopathy (H.I.E) has inspired many studies which tried to identify adequate prognostic factors. Our work aims to find among neonatal parameters:- factors which help to predict the risk to develop both Cerebral Palsy (CP) and secondary Epilepsy at one year of age in subjects affected by perinatal Hypoxic-Ischemic Encephalopathy,- correlations between the neonatal parameters and the variable severity of above mentioned sequelae...
2009: Italian Journal of Pediatrics
Deirdre M Murray, Mairead N O'Riordan, Richard Horgan, Geraldine Boylan, John R Higgins, Cornelius A Ryan
Despite widespread use of fetal heart rate monitoring, the timing of injury in hypoxic-ischemic encephalopathy (HIE) remains unclear. Our aim was to examine fetal heart rate patterns during labor in infants with clinical and electroencephalographic (EEG) evidence of HIE and to relate these findings to neurodevelopmental outcome. Timing of onset of pathological cardiotocographs (CTGs) was determined in each case by two blinded reviewers and related to EEG grade at birth and neurological outcome at 24 months...
September 2009: American Journal of Perinatology
Richard Lester Khan, Magda Lahorgue Nunes, Luis Fernando Garcias da Silva, Jaderson Costa da Costa
The aim of this study was to evaluate the relationship of sequential neonatal electroencephalography (EEG) and neurological outcome in neonates with seizures to identify polysomnographic features predictive of outcome. Sequential EEGs recordings of 58 neonates that belonged to 2 historical cohorts of newborns with seizures from the same neonatal intensive care unit and who had follow-up at the Neurodevelopment Clinic of the Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) in Porto Alegre, Brazil, were analyzed and classified into 4 groups: normal-normal, abnormal-normal, abnormal-abnormal, normal-abnormal...
February 2008: Journal of Child Neurology
Mostafa El-Ayouty, Hesham Abdel-Hady, Sabry El-Mogy, Hamed Zaghlol, Mohamed El-Beltagy, Hany Aly
Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal morbidity and mortality. Electroencephalography (EEG) and brain magnetic resonance imaging (MRI) are frequently performed in these infants, but the prognostic value of the combined use of EEG and MRI needs additional exploration. The purpose of this study was to investigate, in neonates with HIE, the role of early EEG and conventional MRI in the prediction of infants at risk for persistent encephalopathy at 18 months of age. Thirty-four term infants with HIE were enrolled in this prospective study...
September 2007: American Journal of Perinatology
A A Al-Sulaiman, H M Ismail
The clinical patterns, including history, examination, and electroencephalographic (EEG) and computed tomography (CT) findings were examined prospectively in 263 children (153 boys, 110 girls) with newly diagnosed recurrent seizures. The overall mean age was 4. 2 years, with a range of 0.05-13 years. The age of onset was within the first year of life in 128 (48.7%) of the patients. Hypoxic-ischemic encephalopathy (14.8%), febrile seizures (9.1%) and developmental delay (4.6%) were the predominant signs in this age group...
September 1999: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
S Sugama, M Okazaki, Y Nakanishi, F Ito, Y Eto, K Maekawa
In the prediction of neurological sequelae after hypoxic-ischemic encephalopathy (HIE) in the newborn, the electroencephalogram (EEG) burst suppression pattern (BS) and subcortical leukomalacia can mean grave neurodevelopmental problems will develop. This study presents an infant with HIE associated with BS and subcortical leukohypodensity (SLH) on computed tomography scan. At first her neurodevelopmental outcome was considered poor, but unexpectedly she showed good development in 32 months follow-up. The findings of BS and SLH do not always result in a poor neurodevelopmental outcome, if the subsequent clinical state and EEG return to normal at an early stage...
December 1993: Acta Paediatrica Japonica; Overseas Edition
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