Jianjun Liu, Qiulong Yan, Shenghui Li, Juying Jiao, Yiming Hao, Guixin Zhang, Qingkai Zhang, Fei Luo, Yue Zhang, Qingbo Lv, Wenzhe Zhang, Aiqin Zhang, Huiyi Song, Yi Xin, Yufang Ma, Lawrence Owusu, Xiaochi Ma, Peiyuan Yin, Dong Shang
Early dysbiosis in the gut microbiota may contribute to the severity of acute pancreatitis (AP), however, a comprehensive understanding of the gut microbiome, potential pathobionts, and host metabolome in individuals with AP remains elusive. Hence, we employed fecal whole-metagenome shotgun sequencing in 82 AP patients and 115 matched healthy controls, complemented by untargeted serum metabolome and lipidome profiling in a subset of participants. Analyses of the gut microbiome in AP patients revealed reduced diversity, disrupted microbial functions, and altered abundance of 77 species, influenced by both etiology and severity...
March 21, 2024: NPJ Biofilms and Microbiomes