Shirong Lai, Libo Zhang, Xinyu Tu, Xinyue Ma, Yujing Song, Kexin Cao, Miaomiao Li, Jihong Meng, Yiqiang Shi, Qing Wu, Chen Yang, Zifan Lan, Chunyue Geoffrey Lau, Jie Shi, Weining Ma, Shaoyi Li, Yan-Xue Xue, Zhuo Huang
Epileptogenesis, arising from alterations in synaptic strength, shares mechanistic and phenotypic parallels with memory formation. However, direct evidence supporting the existence of seizure memory remains scarce. Leveraging a conditioned seizure memory (CSM) paradigm, we found that CSM enabled the environmental cue to trigger seizure repetitively, and activating cue-responding engram cells could generate CSM artificially. Moreover, cue exposure initiated an analogous process of memory reconsolidation driven by mammalian target of rapamycin-brain-derived neurotrophic factor signaling...
March 22, 2024: Science Advances