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https://www.readbyqxmd.com/read/29146893/von-hippel-lindau-disease-with-multi-organ-involvement-a-case-report-and-8-year-clinical-course-with-follow-up
#1
Ali Yaghobi Joybari, Payam Azadeh
BACKGROUND Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome manifested by a spectrum of benign and malignant tumors.  CASE REPORT The patient presented here was a 31-year-old female with unremarkable family history who presented initially complaining of intermittent abdominal pain. Abdominal CT scan revealed an inhomogeneous solid mass (13×9×7 cm) originating from the tail of the pancreas with splenic and gastric invasion as well as several pancreatic cysts. A nucleotide scan showed left adrenal involvement...
November 17, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29145864/intraductal-tubulopapillary-neoplasm-itpn-of-the-pancreas-associated-with-an-invasive-component-a-case-report-with-review-of-the-literature
#2
Stefanie Kuscher, Hartmut Steinle, Afschin Soleiman, Dietmar Öfner, Stefan Schneeberger, Georg Oberhuber
BACKGROUND: Intraductal tubulopapillary neoplasm (ITPN) depicts a distinct entity in the subgroup of premalignant epithelial tumors of the pancreas. Although the histomorphological and immunophenotypical characterization of ITPN has been described by several authors in terms of report of case series in the past, the rarity of that tumor subtype and similarity to other entities still makes identification of ITPN a challenge for radiologists and pathologists. To date, little is known about tubulopapillary carcinoma that can evolve from ITPN...
November 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29145341/primary-malignant-melanoma-of-the-gallbladder-with-multiple-metastases-a-case-report
#3
Jun-Ke Wang, Fei Su, Wen-Jie Ma, Hai-Jie Hu, Qin Yang, Fei Liu, Quan-Sheng Li, Fu-Yu Li
RATIONAL: Primary malignant melanoma of the gallbladder is an extremely rare tumor, with fewer than 40 cases reported in the literature worldwide. The majority of patients presented as a solitary lesion in the gallbladder. To our knowledge, only one case of primary malignant melanoma of the gallbladder with multiple metastases has been reported, which involved the stomach, duodenum, pancreas, jejunum and a mesenteric lymph node. PATIENT CONCERNS: We report a case of primary malignant melanoma of the gallbladder with metastases to the duodenal bulb, right adrenal and a celiac lymph node...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144798/pancreas-metastases-from-papillary-thyroid-carcinoma-a-review-of-the-literature
#4
Maja Davidson, Randall J Olsen, April A Ewton, Richard J Robbins
OBJECTIVE: Although loco-regional metastases occur in 5-10% of patients with papillary thyroid cancer (PTC), distant metastases are rare, especially to the pancreas. Here we review the literature regarding metastases to the pancreas from PTC and present an illustrative patient. METHODS: The literature search was performed through www.pubmed.org . The information regarding our illustrative case was obtained from the medical records of our institution. RESULTS: Since 1991, 11 cases of pancreas metastases of PTC have been reported...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29143892/update-in-the-therapy-of-advanced-neuroendocrine-tumors
#5
REVIEW
Inbal Uri, Shani Avniel-Polak, David J Gross, Simona Grozinsky-Glasberg
Neuroendocrine tumors (NETs) are rare neoplasms, with an estimated annual incidence of ~ 6.9/100,000. NETs arise throughout the body from cells of the diffuse endocrine system. More than half originate from endocrine cells of the gastrointestinal tract and the pancreas, thus being referred to as gastroenteropancreatic NETs (GEP-NETs). The only treatment that offers a cure is surgery; however, most patients are diagnosed with metastatic disease, and curative surgery is usually not an option. These patients can be offered long-term systemic treatment, for both symptomatic relief and tumor growth suppression...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29143337/intraductal-papillary-mucinous-neoplasm-of-the-pancreas-rapidly-xenografts-in-chicken-eggs-and-predicts-aggressiveness
#6
Zhefu Zhao, Nathalie Bauer, Ewa Aleksandrowicz, Libo Yin, Jury Gladkich, Wolfgang Gross, Jörg Kaiser, Thilo Hackert, Oliver Strobel, Ingrid Herr
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas has a high risk of progressing to invasive pancreatic ductal adenocarcinoma (PDA), but experimental models for IPMN are largely missing. New experimental systems for the molecular characterization of IPMN and for personalized prognosis and treatment options for IPMN are urgently needed. We analyzed the potential use of fertilized chicken eggs for the culture of freshly resected IPMN tissue. We transplanted 49 freshly resected IPMN tissues into eggs and compared the growth characteristics to IPMN tissues transplanted into mice; this was followed by an analysis of histology, morphology and marker expression...
November 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29141455/methionine-adenosyltransferases-in-cancers-mechanisms-of-dysregulation-and-implications-for-therapy
#7
Lauren Y Maldonado, Diana Arsene, José M Mato, Shelly C Lu
Methionine adenosyltransferase genes encode enzymes responsible for the biosynthesis of S-adenosylmethionine, the principal biological methyl donor and precursor of polyamines and glutathione. Mammalian cells express three genes - MAT1A, MAT2A, and MAT2B - with distinct expression and functions. MAT1A is mainly expressed in the liver and maintains the differentiated states of both hepatocytes and bile duct epithelial cells. Conversely, MAT2A and MAT2B are widely distributed in non-parenchymal cells of the liver and extrahepatic tissues...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29141381/-inflammatory-myofibroblastic-tumor-of-the-hepatobiliary-pancreatic-system-report-of-three-cases-and-literature-review
#8
D F Hou, X M Bu, Y Su, C Zhao, G Y Wang, M W Yang
Objective: To improve the understanding, diagnosis and treatment of inflammatory myofibroblastic tumor (IMT) of the hepatobiliary pancreatic system through the cases review. Methods: The clinical data of three cases of pathologically-proved IMT of the hepatobiliary pancreatic system was reported and relevant literatures were reviewed. Results: Among three cases of IMT discussed, there consisted of a case of liver, a case of gallbladder and a case of pancreas. The clinical manifestations were nonspecific, and the preoperative diagnosis was difficult...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29137060/a-case-report-of-mixed-acinar-endocrine-carcinoma-of-the-pancreas-treated-with-s-1-chemotherapy-does-it-work-or-induce-endocrine-differentiation
#9
Masataka Yokode, Ryosuke Itai, Yukimasa Yamashita, Yoh Zen
RATIONALE: Acinar cell carcinomas (ACCs) and mixed acinar-endocrine carcinomas (MAECs) of the pancreas are rare, accounting for only 1% of pancreatic tumors. Although both typically present at an advanced stage, chemotherapeutic regimes have not yet been standardized. PATIENT CONCERNS: A 65-year-old man presented with a large mass in the pancreatic tail with multiple liver metastases. DIAGNOSIS, INTERVENTIONS, OUTCOMES: He was initially treated with gemcitabine for suspected ductal carcinoma of the pancreas, but no response was observed...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29133460/elevated-hur-in-pancreas-promotes-a-pancreatitis-like-inflammatory-microenvironment-that-facilitates-tumor-development
#10
Weidan Peng, Narumi Furuuchi, Ludmila Aslanukova, Yu-Hung Huang, Samantha Z Brown, Wei Jiang, Sankar Addya, Vikalp Vishwakarma, Erika Peters, Jonathan R Brody, Dan A Dixon, Janet A Sawicki
Human antigen R (ELAVL1, HuR) is perhaps the best-characterized RNA-binding protein. Through its overexpression in various tumor types, HuR promotes post-transcriptional regulation of target genes in multiple core signaling pathways associated with tumor progression. The role of HuR overexpression in pancreatic tumorigenesis is unknown and led us to explore the consequences of HuR overexpression using a novel transgenic mouse model that has a >2-fold elevation of pancreatic HuR expression. Histologically, HuR overexpressing pancreas displays a fibro-inflammatory response and other pathological features characteristic of chronic pancreatitis...
November 13, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29129384/radiofrequency-ablation-for-hepatic-oligometastatic-pancreatic-cancer-an-analysis-of-safety-and-efficacy
#11
Yong-Qiang Hua, Peng Wang, Xiao-Yan Zhu, Ye-Hua Shen, Kun Wang, Wei-Dong Shi, Jun-Hua Lin, Zhi-Qiang Meng, Zhen Chen, Hao Chen
OBJECTIVES: This study was to evaluate the value of radiofrequency ablation (RFA) in the treatment of pancreatic cancer with synchronous liver oligometastasis. METHODS: 102 patients diagnosed with pancreatic cancer with synchronous liver oligometastasis undergoing RFA were recruited in this retrospective study between January 2012 and December 2015. Clinical efficacy was evaluated by computed tomography or magnetic resonance imaging 1 month later. All patients were treated with RFA and systemic chemotherapy based on NCCN guideline...
September 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29125479/plasma-3-3-5-triiodo-l-thyronine-t3-level-mirrors-changes-in-tumor-markers-in-two-cases-of-metastatic-cancer-of-the-breast-and-pancreas-treated-with-exogenous-l-t3
#12
Alejandro Rodríguez-Molinero, Aleck Hercbergs, Manuel Sarrias, Antonio Yuste
Preclinical studies have attributed 3,3',5-triiodo-L-thyronine (T3) a direct negative effect on tumor progression, as well as chemosensitizing, differentiating and immunomodulatory properties. On the other hand, L-thyroxine (T4), via a thyroid hormone receptor on plasma membrane integrin αvβ3, promotes solid tumor growth and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth rate. We present the case of two patients with metastatic triple negative breast cancer and metastatic pancreatic cancer respectively, who benefit of the sole treatment with antithyroid drugs and exogenous administration of T3 (liothyronine)...
November 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29124912/metastatic-medullary-thyroid-carcinoma-or-calcitonin-secreting-carcinoid-tumor-of-lung-a-diagnostic-dilemma-in-a-patient-with-lung-mass-and-thyroid-nodule
#13
Shifteh Vahidi, Jimmie Stewart, Khalid Amin, Emilian Racila, Faqian Li
Calcitonin-secreting neuroendocrine tumors are rare and have been reported in literature as case reports or case series in various organs including lung, pancreas, larynx, bladder, and ovary. These tumors have similar cytologic features and immunohistochemical profile to medullary thyroid carcinoma and thus it is difficult to distinguish them, especially when calcitonin-secreting neuroendocrine tumors are intermediate or higher grade and there is a mass lesion in the thyroid gland. Here, we report a rare case of calcitonin secreting atypical carcinoid tumor of the lung in a patient with thyroid nodule...
November 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29124330/-cystic-tumors-of-the-pancreas
#14
EDITORIAL
T Hackert, M W Büchler
No abstract text is available yet for this article.
November 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29124124/preliminary-experience-with-pancreatic-sphincterotomy-as-treatment-for-intraductal-papillary-mucinous-neoplasm-associated-recurrent-pancreatitis
#15
Laura Bernardoni, Stefano Francesco Crinò, Giorgia De Conti, Maria Cristina Conti Bellocchi, Nicolò De Pretis, Antonio Amodio, Luca Frulloni, Armando Gabbrielli
Background and study aims:  Pancreatic intraductal papillary mucinous neoplasms (IPMN) are cystic tumors of the pancreas characterized by a malignant potential. IPMN have been associated with recurrent pancreatitis (RP). Obstruction of the main pancreatic duct by thick mucus has been postulated to be the cause of pancreatitis. In a few isolated reports, pancreatic sphincterotomy (PS) has been reported to reduce the frequency of pancreatitis. The aim of this study was to assess the efficacy of PS in patients with IPMN-associated RP...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29123358/chronic-cancer-pain-diagnostic-dilemma-and-management-challenges
#16
Deepti Ahuja, Sachidanand Jee Bharati, Seema Mishra, Sushma Bhatnagar
A 32-year-old female, diagnosed case of neuroendocrine tumor of pancreas, was admitted to the pain and palliative care unit with complaints of diffuse abdominal pain which was severe in intensity with score on numerical rating scale-9/10. Pain was not relieved even after taking tablet morphine immediate release 360 mg every 4 hourly, paracetamol 500 mg 6 hourly, and gabapentin 300 mg 8 hourly. She had undergone distal pancreatectomy with splenectomy and also received multiple lines of chemotherapy. After making a diagnosis of opioid-induced hyperalgesia, opioid rotation from morphine to fentanyl was done...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29118556/long-non-coding-rna-in-pancreatic-adenocarcinoma-and-pancreatic-neuroendocrine-tumors
#17
REVIEW
Dimitrios Moschovis, Maria Gazouli, Maria Tzouvala, Antonios Vezakis, George Karamanolis
Interest in non-coding regions of DNA has been increasing since the mapping of the human genome revealed that human DNA contains far fewer genes encoding proteins than previously expected. However, analysis of the derivatives of DNA transcription (transcriptomics) revealed that the majority of the genetic material is transcribed into non-coding RNA (ncRNA), indicating that these molecules probably provide the functional diversity and complexity of the physiology of the human body that cannot be attributed to the proteins...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29117940/etv4-facilitates-cell-cycle-progression-in-pancreatic-cells-through-transcriptional-regulation-of-cyclin-d1
#18
Nikhil Tyagi, Sachin K Deshmukh, Sanjeev K Srivastava, Shafquat Azim, Aamir Ahmad, Ahmed Al-Ghadhban, Ajay P Singh, James E Carter, Bin Wang, Seema Singh
The ETS family transcription factor ETV4 is aberrantly expressed in a variety of human tumors and plays an important role in carcinogenesis through upregulation of relevant target gene expression. Here, it is demonstrated that ETV4 is overexpressed in pancreatic cancer (PC) tissues as compared to the normal pancreas, and is associated with enhanced growth and rapid cell cycle progression of PC cells. ETV4 expression was silenced through stable expression of a specific short-interfering hairpin RNA (shRNA) in two PC cell lines (ASPC1 and Colo357), while it was ectopically expressed in BXPC3 cells...
November 8, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29116313/solitary-pancreatic-metastasis-from-breast-cancer-case-report-and-review-of-literature
#19
Márcio Apodaca-Rueda, Fábio Henrique Mendonça Chaim, Milena da Silva Garcia, Helena Paes de Almeida de Saito, Martinho Antonio Gestic, Murillo Pimentel Utrini, Francisco Callejas-Neto, Elinton Adami Chaim, Everton Cazzo
ABSTRACT: HASH(0x3f34538) CONTEXT: Pancreatic metastases from primary malignant tumors at other sites are rare, constituting about 2% of the neoplasms that affect the pancreas. Pancreatic metastasis from breast cancer is extremely rare and difficult to diagnose, because its clinical and radiological presentation is similar to that of a primary pancreatic tumor. CASE REPORT: A 64-year-old female developed a lesion in the pancreatic tail 24 months after neoadjuvant therapy, surgery and adjuvant radiation therapy for right-side breast cancer (ductal carcinoma)...
November 6, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29115542/imp3-overexpression-occurs-in-various-important-cancer-types-and-is-linked-to-aggressive-tumor-features-a-tissue-microarray-study-on-8-877-human-cancers-and-normal-tissues
#20
Christoph Burdelski, Nilofar Jakani-Karimi, Frank Jacobsen, Christina Möller-Koop, Sarah Minner, Ronald Simon, Guido Sauter, Stefan Steurer, Till S Clauditz, Waldemar Wilczak
IMP3 is an RNA binding protein required for ribosomal RNA processing, which has been suggested to be a prognostic marker in a large variety of human types of cancer. However, available data on the prevalence of IMP3 expression are largely discrepant. To systematically investigate the epidemiology and clinical relevance of IMP3 expression in human cancers we employed a two-step tissue microarrays (TMAs) approach. First, a normal tissue TMA and a multi-tumor TMA were analyzed for immunohistochemically detectable expression of IMP3 in 76 different normal tissue types and 3889 cancer samples from 95 different tumor categories...
November 2, 2017: Oncology Reports
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