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https://www.readbyqxmd.com/read/28178209/effects-of-a-combination-of-berberis-aristata-silybum-marianum-and-monacolin-on-lipid-profile-in-subjects-at-low-cardiovascular-risk-a-double-blind-randomized-placebo-controlled-trial
#1
Derosa Giuseppe, D'Angelo Angela, Romano Davide, Maffioli Pamela
The aim of this study was to evaluate the efficacy and safety of an anti-hypercholesterolemic agent containing Berberis aristata, Silybum marianum and monacolin K and KA in a sample of Caucasian patients at low cardiovascular risk according to Framingham score. The primary outcome was to evaluate the effects of this nutraceutical combination on lipid profile; the secondary outcome was to evaluate the effect on some inflammatory markers, in particular high sensitivity C-reactive protein and tumor necrosis factor-α interleukin-6...
February 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28161126/enhancing-silymarin-fractionation-using-the-conductor-like-screening-model-for-real-solvents
#2
Emma C Brace, Abigail S Engelberth
A significant hurdle for discovery of plant-derived products is the numerous trial-and-error experiments required to develop an effective purification strategy. To overcome the experimental burden, a quantum mechanics-based molecular modeling approach - known as the COnductor-like Screening Model for Real Solvents (COSMO-RS) - was used to predict a suitable two-phase solvent system to purify six silymarins from an aqueous mixture. Silymarins, a class of flavonolignans found in milk thistle (Silybum marianum L...
January 23, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28134230/-flavonolignans-compounds-not-only-for-liver-treatment
#3
REVIEW
Michał Bijak
Flavonolignans are the major bioactive components presented in the Milk thistle (Silybum marianum) standarized extract - silymarin. S. marianum is a medicinal plant, which has been using for thousands of years as a remedy for a variety of ailments. Since the 70s of the last century flavonolignans presented in silymarin have been regarded to the official medicine as substances having an hepatoprotective properties. Structurally, flavonolignans are composed of a flavonoid unit (taxifolin) and a phenylpropane unit (coniferyl alcohol), linked together by an oxeran ring...
January 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28125040/silymarin-silybin-and-chronic-liver-disease-a-marriage-of-many-years
#4
REVIEW
Alessandro Federico, Marcello Dallio, Carmelina Loguercio
Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound is silybin, which has a remarkable biological effect. It is used in different liver disorders, particularly chronic liver diseases, cirrhosis and hepatocellular carcinoma, because of its antioxidant, anti-inflammatory and antifibrotic power. Indeed, the anti-oxidant and anti-inflammatory effect of silymarin is oriented towards the reduction of virus-related liver damages through inflammatory cascade softening and immune system modulation...
January 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28124457/effects-of-silymarin-on-diabetes-mellitus-complications-a-review
#5
REVIEW
Aline Maria Stolf, Cibele Campos Cardoso, Alexandra Acco
Diabetes mellitus is a common metabolic disorder that is caused by a deficit in the production of (type 1) or response to (type 2) insulin. Diabetes mellitus is characterized by a state of chronic hyperglycemia and such symptoms as weight loss, thirst, polyuria, and blurred vision. These disturbances represent one of the major causes of morbidity and mortality nowadays, despite available treatments, such as insulin, insulin secretagogues, insulin sensitizers, and oral hypoglycemic agents. However, many efforts have been made to discover new drugs for diabetes treatment, including medicinal plant extracts...
January 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28115903/assessment-of-the-antioxidant-activity-of-silybum-marianum-seed-extract-and-its-protective-effect-against-dna-oxidation-protein-damage-and-lipid-peroxidation
#6
Aynur Serçe, Bircan Çeken Toptancı, Sevil Emen Tanrıkut, Sevcan Altaş, Göksel Kızıl, Süleyman Kızıl, Murat Kızıl
Antioxidant properties of ethanol extract of Silybum marianum (milk thistle) seeds was investigated. We have also investigated the protein damage activated by oxidative Fenton reaction and its prevention by Silybum marianum seed extract. Antioxidant potential of Silybum marianum seed ethanol extract was measured using different in vitro methods, such as lipid peroxidation, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing power assays. The extract significantly decreased DNA damage caused by hydroxyl radicals...
December 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/28111519/statistical-analysis-of-optimal-ultrasound-emulsification-parameters-in-thistle-oil-nanoemulsions
#7
Małgorzata A Miastkowska, Marcin Banach, Jolanta Pulit-Prociak, Elżbieta S Sikora, Agata Głogowska, Michał Zielina
Thistle oil (INCI: Silybum marianum seed oil) is known as an anti-oxidant, moisturizing and skin regenerating cosmetic raw material. Nanoemulsions are a new form of cosmetic product showing very good user properties (ease of spreading over the skin with no greasy feeling). Moreover, due to their structure, they can also transport both hydrophilic and hydrophobic active substances to the skin. The aim of this work was the preparation and characterization of nanoemulsions, based on thistle oil. The non-ionic surfactants polysorbate 80 (PEG-20 sorbitan monooleate), decyl glucoside, and a polyglyceryl-4 ester blend were applied to stabilize the nanosystems...
2017: Journal of Surfactants and Detergents
https://www.readbyqxmd.com/read/28069415/silymarin-exerts-antifungal-effects-via-membrane-targeted-mode-of-action-by-increasing-permeability-and-inducing-oxidative-stress
#8
Dae Gyu Yun, Dong Gun Lee
Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver disorders. It is also consumed as a dietary supplement to improve liver function, as it does not exhibit any toxic effects in humans. Recently, silymarin has been reported to show antimicrobial effects against various pathogenic microorganisms, but the mode of action remains unknown. Thus, we investigated the antifungal activity of silymarin and aimed to determine the underlying mechanism. Initially, a propidium iodide assay was carried out; the results indicated that silymarin induced injury to the fungal plasma membrane...
January 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28066148/inhibition-of-erk1-2-by-silymarin-in-mouse-mesangial-cells
#9
Cha Kyung Youn, Sung Il Cho, Min Young Lee, Young Jin Jeon, Seog Ki Lee
The present study aimed to show that pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-1β] synergistically induce the production of nitric oxide (NO) production in mouse mesangial cells, which play an important role in inflammatory glomerular injury. We also found that co-treatment with cytokines at low doses (TNF-α; 5 ng/ml, IFN-γ; 5 ng/ml, and IL-1β; 1.25 U/ml) synergistically induced NO production, whereas treatment with each cytokine alone did not increase NO production at doses up to 100 ng/ml or 50 U/ml...
January 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28058034/retrospective-analysis-of-the-effects-of-a-highly-standardized-mixture-of-berberis-aristata-silybum-marianum-and-monacolins-k-and-ka-in-patients-with-dyslipidemia
#10
Francesco Di Pierro, Pietro Putignano, Tarcisio Ferrara, Carmela Raiola, Giuliana Rapacioli, Nicola Villanova
BACKGROUND: Berberis aristata, because of its berberine content, and Monascus purpureus fermented rice, because of the presence of monacolins (naturally derived statins), are widely investigated food-grade ingredients used to formulate cholesterol-lowering supplements. Although they are extensively used, berberine is poorly absorbed and monacolins are poorly chemically characterized, not standardized, and possibly contaminated with toxic compounds. Silymarin is reported to enhance berberine absorption, while Monakopure™-K20 (MK-20) is a highly standardized red yeast rice containing monacolins K and KA in the ratio of 1:1 but not secondary monacolins, dehydromonacolins, or citrinin...
2017: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/28042859/a-novel-role-of-silibinin-as-a-putative-epigenetic-modulator-in-human-prostate-carcinoma
#11
Ioannis Anestopoulos, Aristeidis P Sfakianos, Rodrigo Franco, Katerina Chlichlia, Mihalis I Panayiotidis, David J Kroll, Aglaia Pappa
Silibinin, extracted from milk thistle (Silybum marianum L.), has exhibited considerable preclinical activity against prostate carcinoma. Its antitumor and chemopreventive activities have been associated with diverse effects on cell cycle, apoptosis, and receptor-dependent mitogenic signaling pathways. Here we hypothesized that silibinin's pleiotropic effects may reflect its interference with epigenetic mechanisms in human prostate cancer cells. More specifically, we have demonstrated that silibinin reduces gene expression levels of the Polycomb Repressive Complex 2 (PRC2) members Enhancer of Zeste Homolog 2 (EZH2), Suppressor of Zeste Homolog 12 (SUZ12), and Embryonic Ectoderm Development (EED) in DU145 and PC3 human prostate cancer cells, as evidenced by Real Time Polymerase Chain Reaction (RT-PCR)...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28006905/silychristin-skeletal-alterations-and-biological-activities
#12
David Biedermann, Martin Buchta, Veronika Holečková, David Sedlák, Kateřina Valentová, Josef Cvačka, Lucie Bednárová, Alena Křenková, Marek Kuzma, Ctibor Škuta, Žaneta Peikerová, Petr Bartůněk, Vladimír Křen
Silychristin is the second most abundant flavonolignan (after silybin) present in the fruits of Silybum marianum. A group of compounds containing silychristin (3) and its derivatives such as 2,3-dehydrosilychristin (4), 2,3-dehydroanhydrosilychristin (5), anhydrosilychristin (6), silyhermin (7), and isosilychristin (8) were studied. Physicochemical data of these compounds acquired at high resolution were compared. The absolute configuration of silyhermin (7) was proposed to be identical to silychristin A (3a) in ring D (10R,11S)...
December 23, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27976259/an-approved-preparation-of-silybum-marianum-contains-constituents-with-activity-against-plasmodium-falciparum
#13
N Llurba Montesino, M Kaiser, R Brun, T J Schmidt
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975948/silymarin-from-silybum-marianum-new-approaches-to-separation-and-derivatization
#14
D Biedermann, A Křenková, K Valentová, V Křen
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27923566/flavonolignans-inhibit-adp-induced-blood-platelets-activation-and-aggregation-in-whole-blood
#15
Michal Bijak, Rafal Szelenberger, Joanna Saluk, Pawel Nowak
Flavonolignans are a group of active chemical compounds presented in the silymarin - a standardized extract obtained from fruits and seeds of Milk thistle (Silybum marianum L. Gaernt.). Since the 70s of the last century, flavonolignans have been regarded to the official medicine as a substances having hepatoprotective properties. However many researches performed in recent years have demonstrated that flavonolignans posses many other healthy properties including modulation of variety cell-signaling pathways...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27915198/a-new-approach-to-the-rapid-separation-of-isomeric-compounds-in-a-silybum-marianum-extract-using-uhplc-core-shell-column-with-f5-stationary-phase
#16
Jakub Fibigr, Dalibor Šatínský, Petr Solich
In this paper, a new ultra-high performance liquid chromatography (UHPLC) method using a core-shell column with a pentafluorophenyl stationary phase for separation of seven active compounds of a Silybum marianum extract was developed and validated. Silymarin, an extract of Silybum marianum, is known for its abilities to protect the liver from toxic substances, hepatitis therapy, and anti-tumour activity. Silymarin is currently being widely used in commercial preparations and herbal teas. Separation of seven compounds contained in the Silybum marianum extract (taxifolin, silychristin, silydianin, silybin A, silybin B, isosilybin A, isosilybin B) and other substances occurring in real samples was performed on the Kinetex 1...
February 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27906135/seed-germination-and-biochemical-profile-of-silybum-marianum-exposed-to-monometallic-and-bimetallic-alloy-nanoparticles
#17
Muhammad Salman Khan, Mehreen Zaka, Bilal Haider Abbasi, Latifur- Rahman, Afzal Shah
In recent years nanotechnology has become increasingly important in almost every field. The new and improved physical, chemical and biological properties of material at nanoscale have far reaching implications in the fields of science and technology. Nanoparticles' effect on various plant species must be investigated to develop a comprehensive toxicity profile for nanoparticles. The current study strives to evaluate the effects of nine types of metal nanoparticles including monometallic and bimetallic alloy nanoparticles [Ag, Au, Cu, AgCu (1:3), AgCu (3:1), AuCu (1:3), AuCu (3:1), AgAu (1:3), AgAu (3:1)] on seed germination, root and shoot growth and biochemical profile of Silybum marianum plant...
December 2016: IET Nanobiotechnology
https://www.readbyqxmd.com/read/27845613/protective-effect-of-silybum-marianum-and-taraxacum-officinale-extracts-against-oxidative-kidney-injuries-induced-by-carbon-tetrachloride-in-rats
#18
Ali Karakuş, Yeter Değer, Serkan Yıldırım
The protective effect of the extracts of the plants Silybum marianum and Taraxacum officinale by carbon tetrachloride (CCl4) was researched. Sixty-six female Wistar albino rats were divided into six groups: Control, Silybum marianum, Taraxacum officinale, CCl4, Silybum marianum+ CCl4, Taraxacum officinale+CCl4. The Silybum marianum and Taraxacum officinale extracts were administered as 100 mg/kg/day by gavage. The CCl4 was administered as 1.5 mL/kg (i.p.). At the end of the trial period, in the serums obtained from the animals, in the CCl4 group it was found that the MDA level increased in the kidney tissue samples as well as in the ALP and GGT enzyme activities...
November 15, 2016: Renal Failure
https://www.readbyqxmd.com/read/27771919/silymarin-and-its-role-in-chronic-diseases
#19
Neha, Amteshwar S Jaggi, Nirmal Singh
Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. Milk thistle has a lot of traditional values, being used as a vegetable, as salad, as bitter tonic, and as galactogogue in nursing mothers and in various ailments such as liver complications, depression, dyspepsia, spleenic congestions, varicose veins, diabetes, amenorrhea, uterine hemorrhage, and menstrual problems. In this present chapter, a comprehensive attempt has been made to discuss the potential of silymarin in chronic disorders...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27761424/teratogenic-effects-of-silymarin-on-mouse-fetuses
#20
Mahbobe Gholami, Seyed Adel Moallem, Mohammad Afshar, Sakineh Amoueian, Leila Etemad, Gholamreza Karimi
OBJECTIVE: Silybum marianum has been used for centuries in herbal medicine for treatment of liver diseases. Currently, there is no data available on the possible effects of silymarin on fetal development. This study aimed to investigate the teratogenic effect of silymarin on BALB/c mice fetuses. MATERIALS AND METHODS: A total of 40 pregnant mice were divided into 4 groups of 10 mice each. Three groups received silymarin at three different doses of 50, 100 and 200 mg/kg/day during gestational days (GDs)...
September 2016: Avicenna Journal of Phytomedicine
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