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https://www.readbyqxmd.com/read/28807092/extraction-and-determination-of-trace-amounts-of-p-coumaric-acid-in-vinegar-carrot-juice-and-seed-extract-from-silybum-marianum-l-gaertn
#1
Rouhollah Khani, Zeinab Rostami, Ghodsieh Bagherzade, Vahid Khojeh
In this study, for the monitoring and quantification of p-coumaric acid (p-CA) in vinegar, carrot juice, and seed extract from the plant species Silybum marianum (L.) Gaertn, an efficient and low-cost analytical method has been applied. For this purpose, a dispersive liquid-liquid microextraction (DLLME) method, followed by UV-Vis spectrophotometric detection, was used. To form a cloudy solution, a binary mixture containing ethanol as a disperser solvent and chloroform as an extraction solvent was rapidly injected by syringe into a sample solution containing p-CA...
August 10, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28797264/flavonolignans-inhibit-the-arachidonic-acid-pathway-in-blood-platelets
#2
Michal Bijak, Joanna Saluk-Bijak
BACKGROUND: Arachidonic acid metabolism by cyclooxygenase (COX) is a major pathway for blood platelets' activation, which is associated with pro-thrombotic platelet activity and the production of pro-inflammatory mediators. Inhibition of COX activity is one of the major means of anti-platelet pharmacotherapy preventing arterial thrombosis and reducing the incidence of cardiovascular events. Recent studies have presented that a silymarin (standardized extract of Milk thistle (Silybum marianum)) can inhibit the COX pathway...
August 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28735062/silibinin-ameliorates-anxiety-depression-like-behaviors-in-amyloid-%C3%AE-treated-rats-by-upregulating-bdnf-trkb-pathway-and-attenuating-autophagy-in-hippocampus
#3
Xiaoyu Song, Bo Liu, Lingyu Cui, Biao Zhou, Weiwei Liu, Fanxing Xu, Toshihiko Hayashi, Shunji Hattori, Yuko Ushiki-Kaku, Shin-Ichi Tashiro, Takashi Ikejima
Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Depression and anxiety are associated with increased risk of developing AD. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. In this study, the effect of silibinin on Aβ-induced anxiety/depression-like behaviors in rats was investigated. Silibinin significantly attenuated anxiety/depression-like behaviors caused by Aβ1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST)...
July 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28711395/silymarin-ameliorates-experimentally-induced-depressive-like-behavior-in-rats-involvement-of-hippocampal-bdnf-signaling-inflammatory-cytokines-and-oxidative-stress-response
#4
Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Patel
Silymarin is a polyphenolic flavonoid of Silybum marianum, exhibited neuroprotection and antidepressant like activity in acute restraint stressed mice. The main objective of the present study is to investigate possible antidepressant like activity of silymarin in experimentally induced depressive behavior in rats. The depressive behaviors were induced in rats by olfactory bulbectomized (OBX) technique. Wistar rats were administered with silymarin at a dose of 100mg/kg and 200mg/kg, by per oral in OBX and sham operated rats...
July 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28700002/evaluation-of-silybum-marinaum-efficacy-on-university-of-wisconsin-and-histidine-tryptophan-ketoglutarate-solutions-latter-the-damage-of-the-perfused-liver
#5
Nazmi Özer, Ertan Bülbüloğlu, Serdar Yormaz, İlhan Ece
Purpose: To investigate the hepatoprotective and antioxidant effeicacies of Silybum marianum's (silymarin, S) on University of Wisconsin (UW) and histidinetryptophan-ketoglutarate (HTK) preservation solutions. Methods: Thirty two Wistar albino adult male rats were used. Group 1: UW group, Group 2: UW + Silymarin group(S), Group 3: HTK group, Group 4: HTK + silymarin group (S), respectively. Silymarin was enforced intraperitoneally before the surgery. Biopsies were enforced in 0, 6 and 12...
June 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28686955/targeting-stat3-with-silibinin-to-improve-cancer-therapeutics
#6
REVIEW
Joaquim Bosch-Barrera, Bernardo Queralt, Javier A Menendez
Signal transducer and activator of transcription 3 (STAT3) has a prominent role in mediating resistance to conventional chemo-/radio-therapies and modern targeted drugs. While a number of STAT3 inhibitors have been shown to enhance the efficacy of therapeutic agents in vitro, the majority of them have yet to enter clinical evaluation mostly because of lack of efficacy issues. Silibinin is the main component of the silymarin complex, a standardized extract obtained from the seeds of the milk thistle herb Silybum marianum...
June 23, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28685558/bioimpedance-analysis-metabolic-effects-and-safety-of-the-association-berberis-aristata-bilybum-marianum-a-52-week-double-blind-placebo-controlled-study-in-obese-patients-with-type-2-diabetes
#7
RANDOMIZED CONTROLLED TRIAL
G Guarino, F Strollo, L Carbone, T Della Corte, M Letizia, G Marino, S Gentile
Berberine, a quaternary isoquinoline alkaloid present in Berberis aristata, is well known in terms of cholesterol-lowering, hypoglycemic, and insulin sensitizing effects. Because of its low oral bioavailability, to improve intestinal absorption it has been recently combined with silymarin (Silybum marianum). The aim of our placebo controlled study was to evaluate the effects of its association with silymarin on abdominal fat in overweight/obese patients with type 2 diabetes mellitus (T2DM). To do so, 136 obese subjects with T2DM and metabolic syndrome were analyzed for fasting blood glucose and insulin, Insulin Resistance index according to the Homeostatic Model Assessment (HOMA-R), total, HDL and LDL cholesterol, triglycerides, uric acid, BMI, waist circumference, waist to hip ratio and underwent bioelectrical impedance to assess % of abdominal fat...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28672215/silymarin-impacts-on-immune-system-as-an-immunomodulator-one-key-for-many-locks
#8
REVIEW
Nafiseh Esmaeil, Sima Balouchi Anaraki, Marjan Gharagozloo, Behjat Moayedi
Silymarin is a flavonoid complex extracted from the Silybum marianum plant. It acts as a strong antioxidant and free radical scavenger by different mechanisms. But in addition to antioxidant effects, silymarin/silybin reveals immunomodulatory affects with both immunostimulatory and immunosuppression activities. Different studies have shown that silymarin has the anti-inflammatory effect through the suppression of NF-κB signaling pathway and TNF-α activation. It also has different immunomodulatory activities in a dose and time-dependent manner...
June 30, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28653933/comparative-studies-on-rabbit-plasma-lipid-profile-fed-with-silybum-marianum-oil-sunflower-oil-and-vegetable-ghee
#9
Ghosia Lutfullah, Azizur Rahman, Aftab Ahmad, Taufiq Ahmad, Amjad Ali, Jan Alam
Present work is aimed to compare the physicochemical characterization and biochemical effects of oil extracted from Silybum Marianum and Sunflower oil, collected from Peshawar (Pakistan). To investigate the comparative effects on the body weight, organ weight and lipid profile, the crude oil of Silybum marianum, edible sunflower oil and vegetable ghee were given to three groups of rabbits under study. Percent proximate composition and food consumption of all rabbits were determined which showed no significant statistical variation...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28648927/silibinin-capsules-improves-high-fat-diet-induced-nonalcoholic-fatty-liver-disease-in-hamsters-through-modifying-hepatic-de-novo-lipogenesis-and-fatty-acid-oxidation
#10
Chun-Xue Cui, Jing-Na Deng, Li Yan, Yu-Ying Liu, Jing-Yu Fan, Hong-Na Mu, Hao-Yu Sun, Ying-Hong Wang, Jing-Yan Han
ETHNOPHARMACOLOGICAL RELEVANCE: Silibinin Capsules (SC) is a silybin-phospholipid complex with silybin as the bioactive component. Silybin accounts for 50-70% of the seed extract of Silybum marianum (L.) Gaertn.. As a traditional medicine, silybin has been used for treatment of liver diseases and is known to provide a wide range of hepatoprotective effects. AIM OF THE STUDY: High fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) is a worldwide health problem...
June 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28636236/assessment-of-silibinin-as-a-potential-antifungal-agent-and-investigation-of-its-mechanism-of-action
#11
Dae Gyu Yun, Dong Gun Lee
Silibinin, which is derived from Silybum marianum (milk thistle), has used as a traditional remedy for liver or biliary disorders and known to have superior antioxidant activity. In addition, silibinin was recently reported to have antifungal effect related to fungal apoptosis against Candida albicans and the interest in the therapeutic effect is increasing. In this study, we found another mode of antifungal action of silibinin and its antibiofilm activity on C. albicans. To investigate influence on fungal plasma membrane, propidium iodide and bis-(1, 3-dibutylbarbituric acid) trimethineoxonol [DiBAC4 (3)] assay were primarily carried out...
June 21, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28635153/topical-silymarin-administration-for-prevention-of-capecitabine-induced-hand-foot-syndrome-a-randomized-double-blinded-placebo-controlled-clinical-trial
#12
Sepideh Elyasi, Farzaneh Sadat Rezazadeh Shojaee, Abolghasem Allahyari, Gholamreza Karimi
Hand-foot syndrome (HFS) is a frequent dose-limiting adverse reaction of capecitabine in patient with gastrointestinal cancers. Silymarin is a polyphenolic flavonoid extracted from the Silybum marianum that exhibits strong antioxidant and antiinflammatory activities. In this study, we evaluated silymarin efficacy in prevention of capecitabine-induced HFS in patients with gastrointestinal cancers, as the first human study. During this pilot, randomized, double-blinded, placebo-controlled clinical trial, the effect of silymarin gel 1%, which is applied on the palms and soles twice daily starting at the first day of chemotherapy for 9 weeks, on HFS occurrence was assessed...
June 21, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28619387/evaluation-of-ameliorative-ability-of-silibinin-against-zidovudine-and-isoniazid-induced-hepatotoxicity-and-hyperlipidaemia-in-rats-role-of-silibinin-in-phase-i-and-ii-drug-metabolism
#13
Raghu Ramanathan, Karthikeyan Sivanesan
HIV/AIDS patients have suppressed immune system, making them vulnerable to many opportunistic infections including tuberculosis (TB). The patients who are co-infected with TB undergo combined regimens with anti-retroviral drugs such as zidovudine (AZT) and anti-tubercular drug such as isoniazid (INH) for therapy leading to hepatotoxicty. Silibinin (SBN), extracted from Silybum marianum commonly called as "Milk thistle" is used against several drugs-induced hepatotoxicity. The present study evaluates the ameliorative effect of SBN against AZT alone, INH alone, and INH + AZT-induced toxic insults to liver of rats...
June 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28606766/medicinal-species-as-mtdls-turnera-diffusa-willd-ex-schult-inhibits-cns-enzymes-and-delays-glutamate-excitotoxicity-in-sh-sy5y-cells-via-oxidative-damage
#14
João Bernardo, Federico Ferreres, Ángel Gil-Izquierdo, Patrícia Valentão, Paula B Andrade
One of the most promising approaches to confront the complexity of central nervous system disorders are new multi-target directed ligands (MTDLs). Five medicinal species (Cereus grandiflorus (L.) Mill., Hyssopus officinalis L., Acorus calamus L., Silybum marianum L. Gaertn. and Turnera diffusa Willd. Ex Schult), selected for their ethnopharmacological relevance, were object for in vitro screening. The aqueous extract of T. diffusa revealed the strongest neuroactive potential, inhibiting monoamine oxidase-A (IC50 = 129...
June 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28601050/inhibition-of-apoptosis-and-proliferation-in-t-cells-by-immunosuppressive-silymarine
#15
Ehsan Almasi, Marjan Gharagozloo, Nahid Eskandari, Afshin Almasi, Ali Mohammad Sabzghabaee
Silybum marianum, is known to have anti-inflammatory, hepatoprotective and anticarciogenic effects. The aim of this study was to compare effects of Silymarin, Rapamycin and FK506 on proliferation and apoptosis of human T cells stimulated with Con A. Peripheral blood mononuclear cells (PBMC) were stimulated with concavalin A (Con A) (5µg/mL) and then treated with different inhibitors (silymarin, rapamycin and FK506) in various concentrations (5 days). Cells were examined using carboxyfluorescein succinimidyl ester (CFSE) assay for proliferation...
April 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28601049/silymarin-livergol%C3%A2-decreases-disease-activity-score-in-patients-with-rheumatoid-arthritis-a-non-randomized-single-arm-clinical-trial
#16
Mehrdad Shavandi, Ali Moini, Yadollah Shakiba, Ahamad Mashkorinia, Milad Dehghani, Shirin Asar, Amir Kiani
Rheumatoid arthritis (RA) is a chronic autoimmune disease, which can lead to joint destruction and disability. Pannus formation due to chronic synovitis is the hallmark of RA. Oxidative stress as a consequence of immune cell activation and disease-modifying anti-rheumatic drugs can prevent inflammation and tissue destruction. Silymarin, an antioxidant extract from Silybum marianum, has been traditionally used for the treatment of liver diseases for decades. In the present non-randomized single-arm clinical trial (NRSACT) study we evaluated the effects of silymarin tablet (Livergol®) on inflammatory markers in stable RA patients...
April 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28494649/herbicidal-activity-of-pure-compound-isolated-from-rhizosphere-inhabiting-aspergillus-flavus
#17
Saeed Ullah Khattak, Ghosia Lutfullah, Zafar Iqbal, Irshad Ur Rehman, Jamshaid Ahmad, Abid Ali Khan
In the quest for bioactive natural products of fungal origin, Aspergillus flavus was isolated from rhizosphere of Mentha piperita using Potato Dextrose Agar (PDA) and Czapec Yeast Broth (CYB) nutrient media for metabolites production. In total, three different metabolites were purified using HPLC/LCMS and the structures were established using 500 Varian NMR experiments. Further the isolated metabolites in different concentrations (10, 100, 1000 μg/mL) were tested for herbicidal activity using Completely Randomized design (CRD) against the seeds of Silybum marianum and Avena fatua which are major threats to wheat crop in Pakistan...
May 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28483599/therapeutic-effects-of-silibinin-on-lps-induced-acute-lung-injury-by-inhibiting-nlrp3-and-nf-%C3%AE%C2%BAb-signaling-pathways
#18
Lin Tian, Weimin Li, Tan Wang
Silibinin, a natural product extracted from Silybum marianum (milk thistle), has been reported to have anti-inflammatory effect. The aim of this study was to explore the therapeutic effects and potential mechanisms of silibinin on lipopolysaccharide (LPS)-stimulated inflammatory responses in acute lung injury (ALI). Male BALB/c mice were conditioned with silibinin 1 h after intranasal instillation of LPS. After 12 h, the myeloperoxidase (MPO) level in lung tissues, the wet/dry (W/D) ratio, inflammatory cytokines in the bronchoalveolar lavage fluid (BALF), and histopathological examination of lung were detected...
July 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28472840/prediction-of-permeation-and-cellular-transport-of-silybum-marianum-extract-formulated-in-a-nanoemulsion-by-using-pampa-and-caco-2-cell-models
#19
Vieri Piazzini, Chiara Rosseti, Elisabetta Bigagli, Cristina Luceri, Anna Rita Bilia, Maria Camilla Bergonzi
The present study explores the potential of nanoemulsion, a lipid drug delivery system, to improve solubility and oral absorption of Silybum marianum extract. The optimized formulation contained 40 mg/mL of commercial extract (4 % w/w) and it was composed of 2.5 g labrasol (20 %) as the oil phase, 1.5 g cremophor EL as the surfactant, and 1 g labrafil as the cosurfactant (mixture surfactant/cosurfactant, 20 %).The system was characterized by dynamic light scattering, transmission electron microscopy, and HPLC-DAD analyses in order to evaluate size, homogeneity, morphology, and encapsulation efficiency...
May 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/28457856/the-effect-of-milk-thistle-silybum-marianum-and-its-main-flavonolignans-on-cyp2c8-enzyme-activity-in-human-liver-microsomes
#20
Ahmed A Albassam, Reginald F Frye, John S Markowitz
Milk thistle is a widely-consumed botanical used for an array of purported health benefits. The primary extract of milk thistle is termed silymarin, a complex mixture that contains a number of structurally-related flavonolignans, the flavonoid, taxifolin, and a number of other constituents. The major flavonolignans present in most extracts are silybin A, silybin B, isosilybin A and isosilybin B, silydianin, silychristin and isosilychristin. Silymarin itself has been reported to inhibit CYP2C8 activity in vitro, but the effect of the individual flavonolignans on this enzyme has not been studied...
June 1, 2017: Chemico-biological Interactions
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