keyword
MENU ▼
Read by QxMD icon Read
search

Silybum

keyword
https://www.readbyqxmd.com/read/29215318/therapeutic-potential-of-silymarin-in-chronic-unpredictable-mild-stress-induced-depressive-like-behavior-in-mice
#1
Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Patel
Silymarin, a plant-derived polyphenolic flavonoid of Silybum marianum, elicited significant antidepressant-like activity in an acute restraint stress model of depression. It improved monoamines, mainly 5-hydroxytryptamine (5-HT) levels in the cortex, dopamine (DA) and norepinephrine (NE) in the cerebellum in mice. The present study was undertaken to explore the antidepressant potential of silymarin in chronic unpredictable mild stress (CUMS) induced depressive-like behavior in mice, and to find out its probable mechanism(s) of action, mainly neurogenesis, neuroinflammation, and/or oxidative stress...
December 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29125572/silybin-a-major-bioactive-component-of-milk-thistle-silybum-marianum-l-gaernt-chemistry-bioavailability-and-metabolism
#2
REVIEW
Michal Bijak
Milk thistle (Silybum marianum) is a medicinal plant that has been used for thousands of years as a remedy for a variety of ailments. The main component of S. marianum fruit extract (silymarin) is a flavonolignan called silybin, which is not only the major silymarin element but is also the most active ingredient of this extract, which has been confirmed in various studies. This compound belongs to the flavonoid group known as flavonolignans. Silybin's structure consists in two main units. The first is based on a taxifolin, the second a phenyllpropanoid unit, which in this case is conyferil alcohol...
November 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29121705/reactive-oxygen-species-depletion-by-silibinin-stimulates-apoptosis-like-death-in-escherichia-coli
#3
Bin Lee, Dong Gun Lee
Silibinin is the major active component of silymarin, extracted from medicinal plant Silybum marianum. Silibinin has potent antibacterial activity; however, the exact mechanism underlying its activity has not been elucidated. Here, we investigated the novel mechanism of silibinin against Escherichia coli. Time-kill kinetic assay showed that silibinin possess a bactericidal effect at minimal inhibitory concentration (MIC) and higher concentrations (two and four-fold MIC). At the membrane depolarization and increased intracellular Ca²⁺ levels were observed, considered as characteristics of bacterial apoptosis...
November 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29097641/computer-aided-analysis-of-phytochemicals-as-potential-dengue-virus-inhibitors-based-on-molecular-docking-admet-and-dft-studies
#4
Iqra Qaddir, Nouman Rasool, Waqar Hussain, Sajid Mahmood
BACKGROUND & OBJECTIVES: Dengue fever, caused by dengue virus (DENV), has become a serious threat to human lives. Phytochemicals are known to have great potential to eradicate viral, bacterial and fungal-borne diseases in human beings. This study was aimed at in silico drug development against nonstructural protein 4B (NS4B) of dengue virus 4 (DENV4). METHODS: A total of 2750 phytochemicals from different medicinal plants were selected for this study. These plants grow naturally in the climate of Pakistan and India and have been used for the treatment of various pathologies in human for long-time...
July 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29081336/antioxidant-and-anti-aging-activities-of-silybum-marianum-protein-hydrolysate-in-mice-treated-with-d-galactose
#5
Shu Yun Zhu, Ning Jiang, Jie Tu, Jing Yang, Yue Zhou
OBJECTIVE: In the present study, we investigated the antioxidant and anti-aging effects of Silybum marianum protein hydrolysate (SMPH) in D-galactose-treated mice. METHODS: D-galactose (500 mg/kg body weight) was intraperitoneally injected daily for 7 weeks to accelerate aging, and SMPH (400, 800, 1,200 mg/kg body weight, respectively) was simultaneously administered orally. The antioxidant and anti-aging effects of SMPH in the liver and brain were measured by biochemical assays...
September 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29065850/evaluation-of-antioxidant-capacity-and-phenolic-content-in-ethanolic-extracts-of-leaves-and-flowers-of-some-asteraceae-species
#6
Donia Anvari, Rashid Jamei
BACKGROUND: Medicinal plants contain large amount of natural antioxidant compounds, which enable them to neutralize free radicals. Asteraceae family is important source of phytochemical compounds. OBJECTIVE: The objective of this research is to find out the antioxidant potential and radical scavenging from leaf and flowers of five species (Artemisia absinthium L., Arctium lappa L., Silybum marianum L., Centaurea cyanus L. and Echinops ritro L.) of the Asteraceae family...
October 23, 2017: Recent Patents on Food, Nutrition & Agriculture
https://www.readbyqxmd.com/read/29047177/selected-hepatoprotective-herbal-medicines-evidence-from-ethnomedicinal-applications-animal-models-and-possible-mechanism-of-actions
#7
REVIEW
Muhammad Ali, Tariq Khan, Kaneez Fatima, Qurat Ul Ain Ali, Muhammad Ovais, Ali Talha Khalil, Ikram Ullah, Abida Raza, Zabta Khan Shinwari, Muhammad Idrees
Insight into the hepatoprotective effects of medicinally important plants is important, both for physicians and researchers. Main reasons for the use of herbal medicine include their lesser cost compared with conventional drugs, lesser undesirable drug reactions and thus high safety, and reduced side effects. The present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants: Silybum marianum (L.) Gaertn., Glycyrrhiza glabra, Phyllanthus amarus Schumach...
October 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29019957/application-of-multilayer-perceptron-with-automatic-relevance-determination-on-weed-mapping-using-uav-multispectral-imagery
#8
Afroditi A Tamouridou, Thomas K Alexandridis, Xanthoula E Pantazi, Anastasia L Lagopodi, Javid Kashefi, Dimitris Kasampalis, Georgios Kontouris, Dimitrios Moshou
Remote sensing techniques are routinely used in plant species discrimination and of weed mapping. In the presented work, successful Silybum marianum detection and mapping using multilayer neural networks is demonstrated. A multispectral camera (green-red-near infrared) attached on a fixed wing unmanned aerial vehicle (UAV) was utilized for the acquisition of high-resolution images (0.1 m resolution). The Multilayer Perceptron with Automatic Relevance Determination (MLP-ARD) was used to identify the S. marianum among other vegetation, mostly Avena sterilis L...
October 11, 2017: Sensors
https://www.readbyqxmd.com/read/28990236/spatial-organization-of-silybin-biosynthesis-in-milk-thistle-silybum-marianum-l-gaertn
#9
Yongkun Lv, Song Gao, Sha Xu, Guocheng Du, Jingwen Zhou, Jian Chen
Silymarin is a collection of compounds extracted from the medicinal herb milk thistle, among which silybin is the major flavonolignan. However, the biosynthesis pathway of silybin remains unclear. In this study, biomimetic reactions demonstrated that silybin can be synthesized from coniferyl alcohol and taxifolin by the action of peroxidase. The concentration profiles of silybin and its precursors and RNA-Seq analysis of gene expression revealed that the amount of taxifolin and the activity of peroxidase serve as the limiting factors in silybin biosynthesis...
October 9, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28978118/regorafenib-in-combination-with-silybin-as-a-novel-potential-strategy-for-the-treatment-of-metastatic-colorectal-cancer
#10
Valentina Belli, Vincenzo Sforza, Claudia Cardone, Erika Martinelli, Giusi Barra, Nunzia Matrone, Stefania Napolitano, Floriana Morgillo, Concetta Tuccillo, Alessandro Federico, Marcello Dallio, Carmelina Loguercio, Antonietta Gerarda Gravina, Raffaele De Palma, Fortunato Ciardiello, Teresa Troiani
PURPOSE: Regorafenib, an oral multikinase inhibitor, has demonstrated survival benefit in metastatic colorectal cancer (mCRC) patients that have progressed after all standard therapies. However, novel strategies to improve tolerability and enhance anti-cancer efficacy are needed. EXPERIMENTAL DESIGN: We have evaluated in vitro the effects of regorafenib in combination with silybin, a biologically active component extracted from the seeds of Silybum marianum, in a panel of human colon cancer cells...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28964357/the-silymarin-composition%C3%A2-and-why-does-it-matter
#11
Christopher Steven Chambers, Veronika Holečková, Lucie Petrásková, David Biedermann, Kateřina Valentová, Martin Buchta, Vladimír Křen
The extract from milk thistle (Silybum marianum (L.) Gaertn. (Asteraceae)), known as silymarin, contains a variety of flavonolignans and displays antioxidant, anti-inflammatory, immunomodulatory and hepatoprotective properties. As silybin is the main component of silymarin, the literature mainly focuses on this compound, ignoring all other components. This leads to problems in reproducibility of scientific results, as the exact composition of silymarin is often unknown and can vary to a certain degree depending on the processing, chemo-variety of the plant used and climatic conditions during the plant growth...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28863306/the-study-of-flavonolignan-association-patterns-in-fruits-of-diverging-silybum-marianum-l-gaertn-chemotypes-provides-new-insights-into-the-silymarin-biosynthetic-pathway
#12
Tommaso Martinelli, Anne Whittaker, Stefano Benedettelli, Andrea Carboni, Jadwiga Andrzejewska
Silymarin is the phytochemical with medicinal properties extracted from Silybum marianum (L.) Gaertn. fruits. Yet, little information is available about silymarin biosynthesis. Moreover, the generally accepted pathway, formulated thus far, is not in agreement with actual experimental measurements on flavonolignan contents. The present work analyses flavonolignan and taxifolin content in 201 S. marianum samples taking into consideration a wide phenotypic variability. Two stable chemotypes were identified: one characterized by both high silychristin and silybin content (chemotype A) and another by a high silydianin content (chemotype B)...
August 29, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28862663/novelty-detection-classifiers-in-weed-mapping-silybum-marianum-detection-on-uav-multispectral-images
#13
Thomas K Alexandridis, Afroditi Alexandra Tamouridou, Xanthoula Eirini Pantazi, Anastasia L Lagopodi, Javid Kashefi, Georgios Ovakoglou, Vassilios Polychronos, Dimitrios Moshou
In the present study, the detection and mapping of Silybum marianum (L.) Gaertn. weed using novelty detection classifiers is reported. A multispectral camera (green-red-NIR) on board a fixed wing unmanned aerial vehicle (UAV) was employed for obtaining high-resolution images. Four novelty detection classifiers were used to identify S. marianum between other vegetation in a field. The classifiers were One Class Support Vector Machine (OC-SVM), One Class Self-Organizing Maps (OC-SOM), Autoencoders and One Class Principal Component Analysis (OC-PCA)...
September 1, 2017: Sensors
https://www.readbyqxmd.com/read/28842342/phytochemical-analysis-molecular-docking-and-antiamnesic-effects-of-methanolic-extract-of-silybum-marianum-l-gaertn-seeds-in-scopolamine-induced-memory-impairment-in-mice
#14
Nausheen Nazir, Nasiara Karim, Heba Abdel-Halim, Imran Khan, Syed Fazal Wadood, Muhammad Nisar
ETHNOPHARMACOLOGICAL RELEVANCE: Silybum marianum (L.) Gaertn and its main component silymarin have been extensively studied and have been found effective in various neurological disorders. AIMS OF THE STUDY: The aim of the current study is to identify phytoconstituents in the methanolic extract (Me. Ext) of Silybum marianum (L.) Gaertn seeds and to study in-vivo the anti-amnesic effects along with in vitro antioxidant and acetylcholinesterase (AChE) and buteryl cholinesterase (BChE) inhibition potential...
August 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28835005/novel-energy-crops-for-mediterranean-contaminated-lands-valorization-of-dittrichia-viscosa-and-silybum-marianum-biomass-by-pyrolysis
#15
María T Domínguez, Paula Madejón, Engracia Madejón, Manuel J Diaz
Establishing energy crops could be a cost-efficient alternative towards the valorization of the plant biomass produced in contaminated lands, where they would not compete with food production for land use. Dittrichia viscosa and Silybum marianum are two native Mediterranean species recently identified as potential energy crops for degraded lands. Here, we present the first characterization of the decomposition of the biomass of these species during thermo-chemical conversion (pyrolysis). Using a greenhouse study we evaluated whether the quality of D...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28807092/extraction-and-determination-of-trace-amounts-of-p-coumaric-acid-in-vinegar-carrot-juice-and-seed-extract-from-silybum-marianum-l-gaertn
#16
Rouhollah Khani, Zeinab Rostami, Ghodsieh Bagherzade, Vahid Khojeh
In this study, for the monitoring and quantification of p-coumaric acid (p-CA) in vinegar, carrot juice, and seed extract from the plant species Silybum marianum (L.) Gaertn, an efficient and low-cost analytical method has been applied. For this purpose, a dispersive liquid-liquid microextraction (DLLME) method, followed by UV-Vis spectrophotometric detection, was used. To form a cloudy solution, a binary mixture containing ethanol as a disperser solvent and chloroform as an extraction solvent was rapidly injected by syringe into a sample solution containing p-CA...
August 10, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28797264/flavonolignans-inhibit-the-arachidonic-acid-pathway-in-blood-platelets
#17
Michal Bijak, Joanna Saluk-Bijak
BACKGROUND: Arachidonic acid metabolism by cyclooxygenase (COX) is a major pathway for blood platelets' activation, which is associated with pro-thrombotic platelet activity and the production of pro-inflammatory mediators. Inhibition of COX activity is one of the major means of anti-platelet pharmacotherapy preventing arterial thrombosis and reducing the incidence of cardiovascular events. Recent studies have presented that a silymarin (standardized extract of Milk thistle (Silybum marianum)) can inhibit the COX pathway...
August 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28735062/silibinin-ameliorates-anxiety-depression-like-behaviors-in-amyloid-%C3%AE-treated-rats-by-upregulating-bdnf-trkb-pathway-and-attenuating-autophagy-in-hippocampus
#18
Xiaoyu Song, Bo Liu, Lingyu Cui, Biao Zhou, Weiwei Liu, Fanxing Xu, Toshihiko Hayashi, Shunji Hattori, Yuko Ushiki-Kaku, Shin-Ichi Tashiro, Takashi Ikejima
Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Depression and anxiety are associated with increased risk of developing AD. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. In this study, the effect of silibinin on Aβ-induced anxiety/depression-like behaviors in rats was investigated. Silibinin significantly attenuated anxiety/depression-like behaviors caused by Aβ1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST)...
July 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28711395/silymarin-ameliorates-experimentally-induced-depressive-like-behavior-in-rats-involvement-of-hippocampal-bdnf-signaling-inflammatory-cytokines-and-oxidative-stress-response
#19
Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Patel
Silymarin is a polyphenolic flavonoid of Silybum marianum, exhibited neuroprotection and antidepressant like activity in acute restraint stressed mice. The main objective of the present study is to investigate possible antidepressant like activity of silymarin in experimentally induced depressive behavior in rats. The depressive behaviors were induced in rats by olfactory bulbectomized (OBX) technique. Wistar rats were administered with silymarin at a dose of 100mg/kg and 200mg/kg, by per oral in OBX and sham operated rats...
July 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28700002/evaluation-of-silybum-marinaum-efficacy-on-university-of-wisconsin-and-histidine-tryptophan-ketoglutarate-solutions-latter-the-damage-of-the-perfused-liver
#20
Nazmi Özer, Ertan Bülbüloğlu, Serdar Yormaz, İlhan Ece
Purpose: To investigate the hepatoprotective and antioxidant effeicacies of Silybum marianum's (silymarin, S) on University of Wisconsin (UW) and histidinetryptophan-ketoglutarate (HTK) preservation solutions. Methods: Thirty two Wistar albino adult male rats were used. Group 1: UW group, Group 2: UW + Silymarin group(S), Group 3: HTK group, Group 4: HTK + silymarin group (S), respectively. Silymarin was enforced intraperitoneally before the surgery. Biopsies were enforced in 0, 6 and 12...
June 2017: Acta Cirúrgica Brasileira
keyword
keyword
65798
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"