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Cord stem cell transplants

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https://www.readbyqxmd.com/read/28938612/magnetic-resonance-imaging-tracking-and-assessing-repair-function-of-the-bone-marrow-mesenchymal-stem-cells-transplantation-in-a-rat-model-of-spinal-cord-injury
#1
Hongwu Zhang, Liqin Wang, Shihong Wen, Qingfeng Xiang, Xianhong Xiang, Caixia Xu, Yong Wan, Jingnan Wang, Bin Li, Yiqian Wan, Zhiyun Yang, David Y B Deng
The transplantation of bone marrow mesenchymal stem cells (BMSCs) to repair spinal cord injury (SCI) has become a promising therapy. However, there is still a lack of visual evidence directly implicating the transplanted cells as the source of the improvement of spinal cord function. In this study, BMSCs were labeled with NF-200 promoter and lipase-activated gadolinium-containing nanoparticles (Gd-DTPA-FA). Double labeled BMSCs were implanted into spinal cord transaction injury in rat models in situ, the function recovery was evaluated on 1st, 7th, 14th, 28 th days by MRI, Diffusion Tensor Imaing, CT imaging and post-processing, and histological observations...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28935121/treatment-of-acute-ocular-chemical-burns
#2
REVIEW
Namrata Sharma, Manpreet Kaur, Tushar Agarwal, Virender S Sangwan, Rasik B Vajpayee
Ocular chemical burns are an ophthalmic emergency and are responsible for 11.5% to 22.1% of ocular injuries. Immediate copious irrigation is universally recommended in acute ocular burns to remove the offending agent and minimize damage. Conventional medical therapy consists of the use of agents that promote epithelialization, minimize inflammation, and prevent cicatricial complications. Biological fluids such as autologous serum, umbilical cord blood serum, platelet-rich plasma, and amniotic membrane suspension are a rich source of growth factors and promote healing when used as adjuncts to conventional therapy...
September 18, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28928996/immune-mediated-autonomic-neuropathies-following-allogeneic-stem-cell-transplantation-in-acute-myeloid-leukemia
#3
Abhishek Mangaonkar, Hassan Al Khateeb, Narjust Duma, Erik K St Louis, Andrew McKeon, Mrinal Patnaik, William Hogan, Mark Litzow, Taxiarchis Kourelis
BACKGROUND/AIMS: Autonomic dysfunction (AD) after allogeneic stem cell transplant (SCT) is a rare occurrence and likely immune-mediated in etiology. There is limited literature on this topic and hence, we wish to briefly describe management of two cases at our institution and their outcomes. METHODS: We retrospectively identified two patients with immune-mediated AD after SCT from our database. Immune-mediated AD was defined as AD secondary to an immune-mediated etiology without an alternative cause and responding to immunosuppression...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28924462/quantification-of-active-and-latent-form-of-human-cytomegalovirus-infection-in-umbilical-cord-blood-donors-by-real-time-pcr
#4
E Abedi, M Kheirandish, Z Sharifi, S Samiee, P Kokhaei, Z Pourpak, M J Ashraf
BACKGROUND: Umbilical cord blood (UCB) is believed to be a highly valuable source of hematopoietic stem cells for transplantation. Objective: To investigate the prevalence of active and latent human cytomegalovirus (CMV) infection in UCB donors in Iranian population. METHODS: A total of 825 UCB samples was collected under standard procedures and analyzed for the presence of CMV DNAs in buffy coat (latent infection) and plasma (active infection). DNA was extracted from buffy coat and plasma samples separately and tested with quantitative real-time PCR...
2017: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/28921476/expression-of-concern-to-role-of-physiotherapy-in-the-mobilization-of-patients-with-spinal-cord-injury-undergoing-human-embryonic-stem-cells-transplantation
#5
Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri, Rahul Dev Gautam
The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate editorial action will be taken once this has been fully investigated. Geeta Shroff disagrees with this notice. Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam have not responded to our correspondence about this article.
September 18, 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28910960/-effects-of-human-mesenchymal-stem-cells-on-airway-inflammation-in-allergic-asthma-mice-and-the-underlying-mechanism
#6
N N Ren, H J Chen, Q L Chen, J Eileen, Y G An, Yiguang Lin
Objectives: To investigate the effects of human umbilical cord mesenchymal stem cells (hUC-MSCs) on airway inflammation in an ovalbumin (OVA) induced asthma mouse model and the underlying mechanism. Methods: Twenty-four BALB/c mice were randomly divided into four equal groups: normal control group, OVA-induced asthmatic model group, hUC-MSCs treated group (50 μl of hUC-MSCs was transplanted into the trachea of asthmatic mice ) and hUC-MSCs control group (50 μl of hUC-MSCs was transplanted into the trachea of control mice)...
September 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28901182/effects-of-bone-marrow-derived-msc-transplantation-on-functional-recovery-in-a-rat-model-of-spinal-cord-injury-comparisons-of-transplant-locations-and-cell-concentrations
#7
Jessica J Matyas, Andrew N Stewart, Alison Goldsmith, Zhenhong Nan, Reid L Skeel, Julien Rossignol, Gary L Dunbar
Spinal cord injury (SCI) is a widely disabling condition, constraining those affected by it to wheelchairs and requiring intense daily care and assistance. Cell replacement therapies, targeting regeneration of cells in the injured cord, are currently gaining momentum in the field of SCI research. Previous studies indicate that mesenchymal stem cells (MSCs) can reduce functional deficits through immunomodulation and production of trophic factors in a variety of neurological disorders. The present study assessed the efficacy of transplanted bone marrow-derived MSCs at different concentrations and locations for promoting functional recovery following SCI...
August 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28899046/human-neural-stem-cell-transplantation-in-chronic-cervical-spinal-cord-injury-functional-outcomes-at-12-months-in-a-phase-ii-clinical-trial
#8
George M Ghobrial, Kim D Anderson, Marine Dididze, Jasmine Martinez-Barrizonte, Gabriel H Sunn, Katie L Gant, Allan D Levi
No abstract text is available yet for this article.
September 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28887325/at-least-20-donor-myeloid-chimerism-is-necessary-to-reverse-the-sickle-phenotype-after-allogeneic-hsct
#9
Courtney D Fitzhugh, Stefan Cordes, Tiffani Taylor, Wynona Coles, Katherine Roskom, Mary Link, Matthew M Hsieh, John F Tisdale
Novel curative therapies employing genetic transfer of normal globin-producing genes into autologous hematopoietic stem cells (HSCs) are in clinical trials for patients with sickle cell disease (SCD). The percentage of transferred globin necessary to cure SCD is currently not known. In the setting of allogeneic nonmyeloablative hematopoietic stem cell transplants (HSCT), stable mixed chimerism is sufficient to reverse the disease. We regularly monitored 67 patients after HSCT. After initially robust engraftment, three of these patients experienced declining donor myeloid chimerism (DMC) levels with eventual return of disease...
September 8, 2017: Blood
https://www.readbyqxmd.com/read/28886268/implanted-hair-follicle-associated-pluripotent-hap-stem-cells-encapsulated-in-polyvinylidene-fluoride-membrane-cylinders-promote-effective-recovery-of-peripheral-nerve-injury
#10
Aiko Yamazaki, Kohya Obara, Natsuko Tohgi, Kyoumi Shirai, Sumiyuki Mii, Yuko Hamada, Nobuko Arakawa, Ryoichi Aki, Robert M Hoffman, Yasuyuki Amoh
Hair follicle-associated-pluripotent (HAP) stem cells are located in the bulge area of the hair follicle, express the stem-cell marker, nestin, and have been shown to differentiate to nerve cells, glial cells, keratinocytes, smooth muscle cells, cardiac muscle cells, and melanocytes. Transplanted HAP stem cells promote the recovery of peripheral nerve and spinal cord injuries and have the potential for heart regeneration as well. In the present study, we implanted mouse HAP stem-cell spheres encapsulated in polyvinylidene fluoride (PVDF)-membrane cylinders into the severed sciatic nerve of immunocompetent and immunocompromised (nude) mice...
September 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28884834/transplantation-of-hypoxic-preconditioned-neural-stem-cells-benefits-functional-recovery-via-enhancing-neurotrophic-secretion-after-spinal-cord-injury-in-rats
#11
Wei-Li Fan, Peng Liu, Guan Wang, Jung-Ang Pu, Xin Xue, Jian-Hua Zhao
Spinal cord injury (SCI) is a debilitating, costly, and common pathological condition that affects the function of central nervous system (CNS). To date, there are few promising therapeutic strategies available for SCI. To look for a suitable therapeutic strategy, we have developed a sublethal hypoxic preconditioning procedure using Fluorescence-activated cell sorting (FACS) analysis, LDH releasing and cell viability assays in vitro. Meanwhile, we have examined the benefits of neural stem cells (NSCs) transplantation prior to hypoxic preconditioning on functional recovery and potential mechanism via MRI screening, H&E and Nissl staining, immunofluorescence staining and Elisa assays...
September 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28884412/mesenchymal-stem-cells-mscs-therapy-for-recovery-of-fertility-a-systematic-review
#12
REVIEW
Zahra Fazeli, Atieh Abedindo, Mir Davood Omrani, Sayyed Mohammad Hossein Ghaderian
In recent years, the mesenchymal stem cells (MSCs) have provided the new opportunities to treat different disorders including infertility. Different studies have suggested that the MSCs have ability to differentiate into germ-like cells under specific induction conditions as well as transplantation to gonadal tissues. The aim of this systematic review was to evaluate the results obtained from different studies on MSCs therapy for promoting fertility. This search was done in PubMed and Science Direct databases using key words MSCs, infertility, therapy, germ cell, azoospermia, ovarian failure and mesenchymal stem cell...
September 7, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28882029/clinical-observation-of-umbilical-cord-mesenchymal-stem-cell-transplantation-for-treating-patients-receiving-peritoneal-dialysis
#13
Hong-Ying Jiang, Jia-Ping Wang, Yi-Hua Bai, Min Yang, Yi Zeng, Yun-Juan Liao, Zhen-Kun He
BACKGROUND: This study aims to observe the outcome and safety of umbilical cord-mesenchymal stem cell (UC-MSC) treatment for continuous ambulatory peritoneal dialysis (CAPD) patients. METHODS: A total of 24 CAPD patients, who underwent UC-MSC treatment from June 2011 to December 2012, were selected for this study. These patients were followed-up until June 2015. RESULTS: Results revealed a significant increase in HB, EPO and ALB levels, a decrease in CRP levels, and marked improvement in cystatin C and urine volume within three months after UC-MSC transplantation; and the difference was statistically significant (P<0...
September 7, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28863113/the-distribution-of-transplanted-umbilical-cord-mesenchymal-stem-cells-in-large-blood-vessel-of-experimental-design-with-traumatic-brain-injury
#14
Hua-Jiang Dong, Chong-Zhi Shang, Gang Li, Qing Niu, Yue-Chen Luo, Yue Yang, Hui-Peng Meng, Hui-Juan Yin, Hai-Xia Zhang, Ming-Liang Zhao, Ling Lin
The authors aim to track the distribution of human umbilical cord mesenchymal stem cells (MSCs) in large blood vessel of traumatic brain injury -rats through immunohistochemical method and small animal imaging system. After green fluorescent protein (GFP) gene was transfected into 293T cell, virus was packaged and MSCs were transfected. Mesenchymal stem cells containing GFP were transplanted into brain ventricle of rats when the infection rate reaches 95%. The immunohistochemical and small animal imaging system was used to detect the distribution of MSCs in large blood vessels of rats...
September 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28860613/the-stem-cell-regulator-pedf-is-dispensable-for-maintenance-and-function-of-hematopoietic-stem-cells
#15
Emma Rörby, Matilda Billing, Maria Dahl, Sarah Warsi, Silja Andradottir, Kenichi Miharada, Kavitha Siva, Jan-Ingvar Jönsson, Ulrika Blank, Göran Karlsson, Stefan Karlsson
Pigment epithelium derived factor (PEDF), a ubiquitously expressed 50 kDa secreted glycoprotein, was recently discovered to regulate self-renewal of neural stem cells and have a supportive effect on human embryonic stem cell growth. Here, we analyzed expression of PEDF in the murine hematopoietic stem cell (HSC) compartments and found that PEDF is highly expressed in primary long-term HSCs. Therefore, we characterized the hematopoietic system in a knockout mouse model for PEDF and using this model we surprisingly found that PEDF is dispensable for HSC regulation...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28855403/developmental-outcomes-of-cord-blood-transplantation-for-krabbe-disease-a-15-year-study
#16
Matthew D Wright, Michele D Poe, Anthony DeRenzo, Shilpa Haldal, Maria L Escolar
OBJECTIVE: To describe long-term outcomes of children with early-infantile Krabbe disease who underwent hematopoietic stem cell transplantation (HSCT) in the first 7 weeks of life. METHODS: In this prospective longitudinal study, evaluations performed at baseline and follow-up included brain imaging, neurodiagnostic tests, and neurobehavioral evaluations. RESULTS: Of the 18 patients in this study (11 girls, 7 boys; mean follow-up 9.5 years, range 4-15), 5 died (3 of peritransplant complications, 1 of a surgical complication unrelated to Krabbe disease, 1 of disease progression)...
August 30, 2017: Neurology
https://www.readbyqxmd.com/read/28851622/improved-stem-cell-therapy-of-spinal-cord-injury-using-gdnf-overexpressed-bone-marrow-stem-cells-in-a-rat-model
#17
Mostafa Shahrezaie, Reyhaneh Nassiri Mansour, Bahare Nazari, Hadi Hassannia, Fatemeh Hosseini, Hossein Mahboudi, Mohamad Eftekhary, Mousa Kehtari, Arash Veshkini, Abbas Ahmadi Vasmehjani, Seyed Ehsan Enderami
The use of stem cell base therapy as an effective strategy for the treatment of spinal cord injury (SCI) is very promising. Although some strategy has been made to generate neural-like cells using bone marrow mesenchymal stem cells (BMSCs), the differentiation strategies are still inefficiently. For this purpose, we improved the therapeutic outcome with utilize both of N-neurotrophic factor derived Gelial cells (GDNF) gene and differentiation medium that induce the BMSCs into the neural-like cells. The differentiated GDNF overexpressed BMSCs (BMSCs-GDNF) were injected on the third day of post-SCI...
August 26, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28844947/outcome-of-second-transplantation-using-umbilical-cord-blood-for-graft-failure-after-allogeneic-hematopoietic-stem-cell-transplantation-for-aplastic-anemia
#18
Yasushi Onishi, Takehiko Mori, Shinichi Kako, Hideo Koh, Naoyuki Uchida, Tadakazu Kondo, Takeshi Kobayashi, Hiromasa Yabe, Toshihiro Miyamoto, Koji Kato, Ritsuro Suzuki, Shinji Nakao, Hirohito Yamazaki
Graft failure (GF) is the most critical life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT) for aplastic anemia, for which a second transplantation is the only effective treatment. Optimal procedures have not been established for the second transplantation in this setting, however. Here we retrospectively analyzed the outcomes of 22 patients with aplastic anemia, age ≥16 years, who underwent umbilical cord blood transplantation for GF after the first HSCT using the registry database of the Japan Society for Hematopoietic Cell Transplantation...
August 24, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28843345/cyclosporine-immunosuppression-does-not-affect-survival-of-transplanted-skin-derived-precursor-schwann-cells-in-the-injured-rat-spinal-cord
#19
Zacnicte May, Abel Torres-Espín, Ana M Lucas-Osma, Nicholas J Batty, Pamela Raposo, Keith K Fenrich, Morgan G Stykel, Tobias Führmann, Molly Shoichet, Jeff Biernaskie, Karim Fouad
A major goal of Schwann cell (SC) transplantation for spinal cord injury (SCI) is to fill the injury site to create a bridge for regenerating axons. However, transplantation of peripheral nerve SCs requires an invasive biopsy, which may result in nerve damage and donor site morbidity. SCs derived from multipotent stem cells found in skin dermis (SKP-SCs) are a promising alternative. Regardless of source, loss of grafted SCs post-grafting is an issue in studies of regeneration, with survival rates ranging from ∼1 to 20% after ≥6 weeks in rodent models of SCI...
August 24, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28842642/neonatal-umbilical-cord-blood-transplantation-halts-skeletal-disease-progression-in-the-murine-model-of-mps-i
#20
Isabella Azario, Alice Pievani, Federica Del Priore, Laura Antolini, Ludovica Santi, Alessandro Corsi, Lucia Cardinale, Kazuki Sawamoto, Francyne Kubaski, Bernhard Gentner, Maria Ester Bernardo, Maria Grazia Valsecchi, Mara Riminucci, Shunji Tomatsu, Alessandro Aiuti, Andrea Biondi, Marta Serafini
Umbilical cord blood (UCB) is a promising source of stem cells to use in early haematopoietic stem cell transplantation (HSCT) approaches for several genetic diseases that can be diagnosed at birth. Mucopolysaccharidosis type I (MPS-I) is a progressive multi-system disorder caused by deficiency of lysosomal enzyme α-L-iduronidase, and patients treated with allogeneic HSCT at the onset have improved outcome, suggesting to administer such therapy as early as possible. Given that the best characterized MPS-I murine model is an immunocompetent mouse, we here developed a transplantation system based on murine UCB...
August 25, 2017: Scientific Reports
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