keyword
https://read.qxmd.com/read/37935915/can-research-on-entactogens-contribute-to-a-deeper-understanding-of-human-sexuality
#21
REVIEW
Justyna Holka-Pokorska
In recent years, scientific research into the therapeutic potential of psychedelic compounds has experienced a resurgence of interest. New studies have shown promising results, supporting the use of psychedelic drugs in treating various psychiatric disorders, including treatment-resistant depression, post-traumatic stress disorder, and even alcohol addiction. The FDA has recognized 3,4-methylenedioxymethamphetamine (MDMA) as a breakthrough therapy to treat symptoms of post-traumatic stress disorder. At the same time, interviews with recreational MDMA users have documented experiences of emotional intimacy while using MDMA, often without the desire for penetrative sex...
November 8, 2023: Pharmacological Reports: PR
https://read.qxmd.com/read/37913985/intranasal-oxytocin-alleviates-comorbid-depressive-symptoms-in-neuropathic-pain-via-elevating-hippocampal-bdnf-production-in-both-female-and-male-mice
#22
JOURNAL ARTICLE
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
The comorbidity of pain and depression is frequently observed in patients suffering from chronic pain and depression. However, the comorbid mechanism is not well elucidated and the therapeutic medication is still inadequate. Oxytocin is a neuropeptide synthesized in the hypothalamus. It has been reported to relieve chronic pain and depressive symptoms. However, the analgesic action and mechanisms of oxytocin have mainly been investigated using peripheral or spinal administration. Because of the advantage of intranasal delivery of oxytocin in crossing the blood-brain barrier, we investigated the effect of intranasal application of oxytocin on neuropathic pain and comorbid depressive symptoms in both female and male mice...
October 30, 2023: Neuropharmacology
https://read.qxmd.com/read/37907193/exposure-to-different-pm-2-5-extracts-induces-gliosis-and-changes-behavior-in-male-rats-similar-to-autism-spectrum-disorders-features
#23
JOURNAL ARTICLE
Masoumeh Rahmatinia, Anoushiravan Mohseni-Bandpei, Fariba Khodagholi, Mohammad-Amin Abdollahifar, Mehdi Amouei Torkmahalleh, Meysam Hassani Moghaddam, Philip K Hopke, Ehsan Ghavimehr, Shahriyar Bazzazpour, Abbas Shahsavani
Epidemiological studies have documented that exposure to fine particulate matter (PM2.5 ) could affect neurodevelopment, thereby leading to autism spectrum disorders (ASD). Nevertheless, there is little laboratory data to support this epidemiological evidence. In the current study, we carried out a series of experiments to assess whether developmental exposures to different extracts of PM2.5 can result in ASD-like behavioral, biochemical, and immunohistochemical characteristics in male rat offspring. PM2.5 samples were collected daily for a year, and monthly composites were extracted with an acetone-hexane mixture...
October 29, 2023: Environmental Pollution
https://read.qxmd.com/read/37906349/breastfeeding-and-postpartum-depression-a-review-of-relationships-and-potential-mechanisms
#24
REVIEW
Erin J Henshaw
PURPOSE OF REVIEW: Postpartum depression (PPD) and breastfeeding are important, interrelated health factors. It is established that women who breastfeed exclusively have lowered likelihood of developing significant PPD. Yet, many questions remain around what factors are involved. The purpose of this review is to provide updated information about the relationship between PPD and breastfeeding. RECENT FINDINGS: Both psychological and physiological factors have emerged as important moderators and mechanisms of the relationship between postpartum depression and breastfeeding...
October 31, 2023: Current Psychiatry Reports
https://read.qxmd.com/read/37883133/the-mood-mother-and-child-study-protocol-for-a-prospective-longitudinal-study-and-randomized-controlled-trial
#25
JOURNAL ARTICLE
W Roger Mills-Koonce, Karen Grewen, Nisha Gottredson O'Shea, Brenda Pearson, Chelsea Grace Strange, Samantha E Meltzer-Brody, Jerry Dolph Guintivano, Alison M Stuebe
BACKGROUND: Perinatal depression affects >400,000 mother-child dyads in the United States every year and is associated with numerous adverse maternal and child developmental outcomes. Previous research implicates the dysregulation of oxytocin and the hypothalamic-pituitary-adrenal (HPA) axis functioning in mothers and children as potential mechanisms mediating or moderating the transmission of risk associated with maternal depression. OBJECTIVE: The Mood, Mother and Child study will examine the psychobiological sources of risk and resilience within mother-child dyads affected by maternal depression...
October 26, 2023: JMIR Research Protocols
https://read.qxmd.com/read/37837804/the-use-of-intranasal-oxytocin-in-the-treatment-of-eating-disorders
#26
REVIEW
Magda Malewska-Kasprzak, Katarzyna Jowik, Marta Tyszkiewicz-Nwafor
Oxytocin (OXT) is a hypothalamic peptide that plays a number of roles in the body, being involved in labor and lactation, as well as cognitive-emotional processes and social behavior. In recent years, knowledge of the physiology of OXT has been repeatedly used to explore its potential role in the treatment of numerous diseases, identifying a significant role for OXT in appetite regulation, eating behavior, weight regulation, and food-related beliefs. In this review we provide an overview of publications on this topic, but due to the wealth of research, we have limited our focus to studies based on the use of intranasal OXT in psychiatric diseases, with a particular focus on the role of oxytocin in eating disorders and obesity...
October 12, 2023: Neuropeptides
https://read.qxmd.com/read/37706061/sex-and-hormonal-status-influence-the-anxiolytic-like-effect-of-oxytocin-in-mice
#27
JOURNAL ARTICLE
Khalin E Nisbett, Luis A Gonzalez, Marina Teruel, C Sue Carter, Leandro F Vendruscolo, Michael E Ragozzino, George F Koob
Anxiety and depression are highly prevalent psychiatric disorders, affecting approximately 18% of the United States population. Evidence indicates that central oxytocin mediates social cognition, social bonding, and social anxiety. Although it is well-established that oxytocin ameliorates social deficits, less is known about the therapeutic effects of oxytocin in non-social contexts. We hypothesized that positive effects of oxytocin in social contexts are attributable to intrinsic effects of oxytocin on neural systems that are related to emotion regulation...
September 2023: Neurobiology of Stress
https://read.qxmd.com/read/37678086/prolonged-ketamine-therapy-differentially-rescues-psychobehavioural-deficits-via-modulation-of-nitro-oxidative-stress-and-oxytocin-receptors-in-the-gut-brain-axis-of-chronically-stressed-mice
#28
JOURNAL ARTICLE
Edem Ekpenyong Edem, Oluwatomisn Adeyosola Oguntala, Daniel Akinwale Ikuelogbon, Kate Eberechukwu Nebo, Adedamola Adediran Fafure, Elizabeth Toyin Akinluyi, Godspower Tochukwu Isaac, Oladunni Eunice Kunlere
Ketamine is an anaesthetic known to have short but rapid-acting anti-depressant effects; however, the neurobehavioural effects of its prolonged use and its role on the oxytocin system in the gut-brain axis are largely undetermined. Female BALB/c mice were either exposed to the chronic unpredictable mild stress (CUMS) paradigm for 21 days and then treated with ketamine in four doses for 14 days or exposed to CUMS and treated simultaneously in four doses of ketamine during the last two weeks of CUMS exposure...
August 23, 2023: Psychoneuroendocrinology
https://read.qxmd.com/read/37669858/energy-expenditure-homeostasis-requires-erbb4-an-obesity-risk-gene-in-the-paraventricular-nucleus
#29
JOURNAL ARTICLE
Ivan Santiago-Marrero, Fang Liu, Hongsheng Wang, Emily P Arzola, Wen-Cheng Xiong, Lin Mei
Obesity affects more than a third adult population in the United States; the prevalence is even higher in patients with major depression disorders. GWAS studies identify the receptor tyrosine kinase ErbB4 as a risk gene for obesity and for major depression disorders. We found that ErbB4 was enriched in the paraventricular nucleus of the hypothalamus (PVH). To investigate its role in metabolism, we deleted ErbB4 by injecting a Cre-expressing virus into the PVH of ErbB4 floxed male mice and found that PVH ErbB4 deletion increased weight gain without altering food intake...
September 4, 2023: ENeuro
https://read.qxmd.com/read/37628589/genetics-of-functional-seizures-a-scoping-systematic-review
#30
JOURNAL ARTICLE
Ali A Asadi-Pooya, Mark Hallett, Nafiseh Mirzaei Damabi, Khatereh Fazelian Dehkordi
BACKGROUND: Evidence on the genetics of functional seizures is scarce, and the purpose of the current scoping systematic review is to examine the existing evidence and propose how to advance the field. METHODS: Web of science and MEDLINE were searched, from their initiation until May 2023. The following key words were used: functional neurological disorder(s), psychogenic neurological disorder(s), functional movement disorder(s), psychogenic movement disorder(s), functional seizures(s), psychogenic seizure(s), nonepileptic seizure(s), dissociative seizure(s), or psychogenic nonepileptic seizure(s), AND, gene, genetic(s), polymorphism, genome, epigenetics, copy number variant, copy number variation(s), whole exome sequencing, or next-generation sequencing...
July 27, 2023: Genes
https://read.qxmd.com/read/37607897/correction-to-oxytocin-system-polymorphisms-rs237887-and-rs2740210-variants-increase-the-risk-of-depression-in-pregnant-women-with-early-abuse
#31
(no author information available yet)
No abstract text is available yet for this article.
September 2023: Developmental Psychobiology
https://read.qxmd.com/read/37595325/biological-markers-of-sex-based-differences-in-major-depressive-disorder-and-in-antidepressant-response
#32
REVIEW
Rosana Carvalho Silva, Claudia Pisanu, Elisabetta Maffioletti, Valentina Menesello, Marco Bortolomasi, Massimo Gennarelli, Bernhard T Baune, Alessio Squassina, Alessandra Minelli
Major depressive disorder (MDD) presents different clinical features in women and men, with women being more affected and responding differently to antidepressant treatment. Specific molecular mechanisms underlying these differences are not well studied and this narrative review aims at providing an overview of the neurobiological features underlying sex-differences in biological systems involved in MDD pathophysiology and response to antidepressant treatment, focusing on human studies. The majority of the reviewed studies were performed through candidate gene approaches, focusing on biological systems involved in MDD pathophysiology, including the stress response, inflammatory and immune, monoaminergic, neurotrophic, gamma-aminobutyric acid and glutamatergic, and oxytocin systems...
August 16, 2023: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/37566543/investigation-of-hypothalamic-pituitary-adrenal-axis-and-oxytocinergic-system-changes-in-a-pragmatic-randomized-controlled-feasibility-trial-of-acupuncture-for-antenatal-depression
#33
RANDOMIZED CONTROLLED TRIAL
Simone M Ormsby, Hannah G Dahlen, Caroline A Smith
Background: Antenatal depression is common and associated with detrimental impacts on women and their families. Disrupted neuroendocrine functioning is reported in women experiencing perinatal mental health disturbances. Preliminary randomized controlled trial (RCT) evidence suggests acupuncture may provide a safe and effective adjunct treatment; however, underlying mechanisms of effect are unclear. We conducted an RCT examination of acupuncture for the management of antenatal depressive symptomologies, which included oxytocinergic and hypothalamic pituitary adrenal (HPA) axis system evaluations...
February 2024: J Integr Complement Med
https://read.qxmd.com/read/37532013/chemogenetic-activation-of-oxytocin-neurons-improves-pain-in-a-reserpine-induced-fibromyalgia-rat-model
#34
JOURNAL ARTICLE
Naofumi Ikeda, Makoto Kawasaki, Kazuhiko Baba, Haruki Nishimura, Teruaki Fujitani, Hitoshi Suzuki, Takanori Matsuura, Hideo Ohnishi, Makiko Shimizu, Kenya Sanada, Kazuaki Nishimura, Mitsuhiro Yoshimura, Takashi Maruyama, Becky L Conway-Campbell, Tatsushi Onaka, Hitoshi Teranishi, Reiko Hanada, Yoichi Ueta, Akinori Sakai
Fibromyalgia (FM) is a syndrome characterized by chronic pain with depression as a frequent comorbidity. However, efficient management of the pain and depressive symptoms of FM is lacking. Given that endogenous oxytocin (OXT) contributes to the regulation of pain and depressive disorders, herein, we investigated the role of OXT in an experimental reserpine-induced FM model. In FM model, OXT-monomeric red fluorescent protein 1 (OXT-mRFP1) transgenic rats exhibited increased depressive behavior and sensitivity in a mechanical nociceptive test, suggesting reduced pain tolerance...
July 31, 2023: Neuroscience
https://read.qxmd.com/read/37520225/the-oxytocin-receptor-rs2254298-polymorphism-and-alcohol-withdrawal-symptoms-a-gene-environment-interaction-in-mood-disorders
#35
JOURNAL ARTICLE
Guanghui Shen, Shizhuo Yang, Liujun Wu, Yingjie Chen, Yueling Hu, Fan Zhou, Wei Wang, Peining Liu, Fenzan Wu, Yanlong Liu, Fan Wang, Li Chen
OBJECTIVE: Alcohol use disorder (AUD) is a common mental disorder characterized by repeated withdrawal episodes. Negative emotions during withdrawal are the primary factors affecting successful abstinence. Oxytocin is a critical modulator of emotions. OXTR, the oxytocin receptor, may also be a promising candidate for treating alcohol withdrawal symptoms. Previous studies indicated that people with different genotypes of OXTR rs2254298 were reported to suffer from more significant depressive or heightened anxiety symptoms when experiencing early adversity...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37475002/-effect-of-processing-with-vinegar-on-efficacy-of-curcuma-longa-in-treatment-of-dysmenorrhea-in-rats-with-syndrome-of-liver-depression-and-qi-stagnation
#36
JOURNAL ARTICLE
Jie Wu, Ma-Yi-Jie Cao, Ying Peng, Bao-Hua Dong, Yun-Xiu Jiang, Peng-Jin Zhu, Chang-Jiang Hu, Run-Chun Xu, Zhi-Min Chen
This study compared the effects of Curcuma longa before and after processing with vinegar on the rat model of dysmenorrhea with the syndrome of liver depression and Qi stagnation to reveal the mechanism of vinegar processing in improving the role of C. longa in soothing liver and relieving pain. The rat model of dysmenorrhea with the syndrome of liver depression and Qi stagnation was established according to the Preparation of the Animal Model of Dysmenorrhea(Draft) and the chronic unpredictable stress me-thod...
July 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/37445607/the-role-of-oxytocin-in-early-life-stress-related-neuropsychiatric-disorders
#37
REVIEW
Yue Jin, Da Song, Yan Yan, Zhenzhen Quan, Hong Qing
Early-life stress during critical periods of brain development can have long-term effects on physical and mental health. Oxytocin is a critical social regulator and anti-inflammatory hormone that modulates stress-related functions and social behaviors and alleviates diseases. Oxytocin-related neural systems show high plasticity in early postpartum and adolescent periods. Early-life stress can influence the oxytocin system long term by altering the expression and signaling of oxytocin receptors. Deficits in social behavior, emotional control, and stress responses may result, thus increasing the risk of anxiety, depression, and other stress-related neuropsychiatric diseases...
June 21, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37439738/biological-marker-of-withdrawal-ruptures-dyadic-pattern-of-incongruence-in-oxytocin-release
#38
JOURNAL ARTICLE
Shachaf Tal, Amit Tchizick, Simone Shamay-Tsoory, Tohar Dolev-Amit, Sigal Zilcha-Mano
Despite widespread clinical, theoretical, and empirical support for the importance of alliance ruptures, little is known about the underlying biological level at times of rupture. The overarching goal of the present study was to investigate dyadic patterns of in-session oxytocin (OT) change between patients and therapists (e.g., patient's OT increases more than therapist's OT) as markers of withdrawal ruptures. Hypothesis 1 construed that OT incongruence (e.g., larger patient increase in OT in comparison to their therapist OT increase) will mark the occurrence of withdrawal ruptures...
July 13, 2023: Journal of Counseling Psychology
https://read.qxmd.com/read/37424418/oxytocin-levels-in-children-with-separation-anxiety-and-their-mothers-before-and-after-treatment
#39
JOURNAL ARTICLE
Nur Seda Gülcü Üstün, Şefika Nur Gümüş, Nusret Soylu
OBJECTIVE: The purpose of this study was to compare the plasma oxytocin levels of children with separation anxiety disorder (SAD) and their mothers with those of healthy controls and to examine the relationship between oxytocin levels and changes in anxiety three months after treatment. METHODS: Thirty children aged 6-12 years with SAD, 30 healthy children, and mothers of both groups were included in the study. All cases were evaluated with semi-structured interview and Clinical Global Impression Scale...
August 31, 2023: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://read.qxmd.com/read/37420191/the-association-between-neuropeptide-oxytocin-and-neuropsychiatric-disorders-after-orthopedic-surgery-stress-in-older-patients
#40
JOURNAL ARTICLE
Wanru Dong, Zengbo Ding, Xiao Wu, Ran Wan, Ying Liu, Liubao Pei, Weili Zhu
BACKGROUND: The health outcomes of geriatric patients exposed to surgery were found to be enhanced by social support and stress management. The aim of this study was to characterise the relationship between oxytocin and neuropsychiatric disorders after surgery. METHODS: A total of 132 geriatric patients aged ≥ 60 years received orthopedic surgery in the First Affiliated Hospital of Harbin Medical University (Harbin, China) were enrolled in the present study...
July 7, 2023: BMC Geriatrics
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