Naofumi Ikeda, Makoto Kawasaki, Kazuhiko Baba, Haruki Nishimura, Teruaki Fujitani, Hitoshi Suzuki, Takanori Matsuura, Hideo Ohnishi, Makiko Shimizu, Kenya Sanada, Kazuaki Nishimura, Mitsuhiro Yoshimura, Takashi Maruyama, Becky L Conway-Campbell, Tatsushi Onaka, Hitoshi Teranishi, Reiko Hanada, Yoichi Ueta, Akinori Sakai
Fibromyalgia (FM) is a syndrome characterized by chronic pain with depression as a frequent comorbidity. However, efficient management of the pain and depressive symptoms of FM is lacking. Given that endogenous oxytocin (OXT) contributes to the regulation of pain and depressive disorders, herein, we investigated the role of OXT in an experimental reserpine-induced FM model. In FM model, OXT-monomeric red fluorescent protein 1 (OXT-mRFP1) transgenic rats exhibited increased depressive behavior and sensitivity in a mechanical nociceptive test, suggesting reduced pain tolerance...
July 31, 2023: Neuroscience